long term potentiation

Summary

Summary: A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.

Top Publications

  1. pmc Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
  2. ncbi LTP and LTD: an embarrassment of riches
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 44:5-21. 2004
  3. ncbi Storage of spatial information by the maintenance mechanism of LTP
    Eva Pastalkova
    Departments of Physiology, Pharmacology, and Neurology, Robert F Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Science 313:1141-4. 2006
  4. ncbi The molecular biology of memory storage: a dialogue between genes and synapses
    E R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Science 294:1030-8. 2001
  5. ncbi Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
    A Barria
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Science 276:2042-5. 1997
  6. ncbi Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory
    Hey Kyoung Lee
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Cell 112:631-43. 2003
  7. ncbi Fear conditioning induces associative long-term potentiation in the amygdala
    M T Rogan
    Center for Neural Science, New York University, New York 10003, USA
    Nature 390:604-7. 1997
  8. ncbi Synaptic tagging and long-term potentiation
    U Frey
    Federal Institute for Neurobiology, Gene Regulation and Plasticity, Magdeburg, Germany
    Nature 385:533-6. 1997
  9. ncbi Mechanisms of amygdala modulation of hippocampal plasticity
    Irit Akirav
    Laboratory of Behavioral Neuroscience, Department of Psychology, University of Haifa, Haifa 31905, Israel
    J Neurosci 22:9912-21. 2002
  10. ncbi Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo
    Elhoucine Messaoudi
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, N 5009 Bergen, Norway
    J Neurosci 27:10445-55. 2007

Detail Information

Publications379 found, 100 shown here

  1. pmc Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
    ..They further suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long-term memory...
  2. ncbi LTP and LTD: an embarrassment of riches
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 44:5-21. 2004
    ..Here we review those forms of LTP and LTD for which mechanisms have been most firmly established. Examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function...
  3. ncbi Storage of spatial information by the maintenance mechanism of LTP
    Eva Pastalkova
    Departments of Physiology, Pharmacology, and Neurology, Robert F Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Science 313:1141-4. 2006
    ..Thus, the mechanism maintaining LTP sustains spatial memory...
  4. ncbi The molecular biology of memory storage: a dialogue between genes and synapses
    E R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Science 294:1030-8. 2001
    ....
  5. ncbi Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
    A Barria
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Science 276:2042-5. 1997
    ..This covalent modulation of AMPA-Rs in LTP provides a postsynaptic molecular mechanism for synaptic plasticity...
  6. ncbi Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory
    Hey Kyoung Lee
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Cell 112:631-43. 2003
    ..The phosphomutant mice show deficits in LTD and LTP and have memory defects in spatial learning tasks. These results demonstrate that phosphorylation of GluR1 is critical for LTD and LTP expression and the retention of memories...
  7. ncbi Fear conditioning induces associative long-term potentiation in the amygdala
    M T Rogan
    Center for Neural Science, New York University, New York 10003, USA
    Nature 390:604-7. 1997
    ..LTP-like associative processes thus occur during fear conditioning, and these may underlie the long-term associative plasticity that constitutes memory of the conditioning experience...
  8. ncbi Synaptic tagging and long-term potentiation
    U Frey
    Federal Institute for Neurobiology, Gene Regulation and Plasticity, Magdeburg, Germany
    Nature 385:533-6. 1997
    ..The synaptic tag decays in less than three hours. These findings indicate that the persistence of LTP depends not only on local events during its induction, but also on the prior activity of the neuron...
  9. ncbi Mechanisms of amygdala modulation of hippocampal plasticity
    Irit Akirav
    Laboratory of Behavioral Neuroscience, Department of Psychology, University of Haifa, Haifa 31905, Israel
    J Neurosci 22:9912-21. 2002
    ..Possibly, at the onset of an emotional event the stress hormones permissively mediate plasticity. However, their prolonged presence in the system may suppress the cognitive response to stress...
  10. ncbi Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo
    Elhoucine Messaoudi
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, N 5009 Bergen, Norway
    J Neurosci 27:10445-55. 2007
    ..Furthermore, Arc synthesis is required for both the induction and consolidation of LTP elicited by local BDNF infusion, thus identifying Arc as a key molecular effector of BDNF in synaptic plasticity...
  11. ncbi Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice
    Agnes Gruart
    Division de Neurociencias, Universidad Pablo de Olavide, 41013 Sevilla, Spain
    J Neurosci 26:1077-87. 2006
    ..Our results provide evidence of a relationship between activity-dependent synaptic plasticity and associative learning in behaving mice...
  12. ncbi The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    J Z Tsien
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1327-38. 1996
    ..Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories...
  13. ncbi Plasticity in the human central nervous system
    S F Cooke
    Division of Neurophysiology, National Institute for Medical Research London, UK
    Brain 129:1659-73. 2006
    ..These techniques have potential therapeutic application in manipulating neural plasticity to treat a variety of conditions, including depression, Parkinson's disease, epilepsy and neuropathic pain...
  14. ncbi Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation
    Peter Serrano
    Department of Physiology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Neurosci 25:1979-84. 2005
    ..An inactive scrambled version of the peptide had no effect on LTP. Thus, persistent, increased phosphorylation by PKMzeta specifically maintains the late phase of LTP...
  15. ncbi Learning modifies subsequent induction of long-term potentiation-like and long-term depression-like plasticity in human motor cortex
    Ulf Ziemann
    Motor Cortex Laboratory, Clinic of Neurology, Johann Wolfgang Goethe University, D 60528 Frankfurt am Main, Germany
    J Neurosci 24:1666-72. 2004
    ..The same number of repeated slow thumb abduction movements did not result in learning and had no effects on PAS-induced plasticity. Findings support the view that learning in human M1 occurs through LTP-like mechanisms...
  16. pmc AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis
    Hiroshi Makino
    Department of Neurosciences, Division of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 64:381-90. 2009
    ..These exocytosed receptors likely serve to replenish the local extrasynaptic pool available for subsequent bouts of plasticity. These results clarify the role of intracellular and surface AMPARs during synaptic plasticity...
  17. ncbi Synaptic amplifier of inflammatory pain in the spinal dorsal horn
    Hiroshi Ikeda
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Science 312:1659-62. 2006
    ..This model integrates known signal transduction pathways of hyperalgesia without contradiction...
  18. ncbi Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation
    Charles D Kopec
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:2000-9. 2006
    ..Interestingly, during chemLTP induction, spines increase in volume before accumulation of AMPA receptors on their surface, indicating that distinct mechanisms underlie changes in morphology and receptor content...
  19. ncbi Genetic enhancement of learning and memory in mice
    Y P Tang
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Nature 401:63-9. 1999
    ..Our results suggest that genetic enhancement of mental and cognitive attributes such as intelligence and memory in mammals is feasible...
  20. ncbi Translational control by MAPK signaling in long-term synaptic plasticity and memory
    Raymond J Kelleher
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Departments of Biology and Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA
    Cell 116:467-79. 2004
    ..These results suggest a crucial role for translational control by MAPK signaling in long-lasting forms of synaptic plasticity and memory...
  21. ncbi Effects of chronic stress on hippocampal long-term potentiation
    Constantine Pavlides
    The Rockefeller University, New York, New York 10021, USA
    Hippocampus 12:245-57. 2002
    ..Furthermore, they suggest that chronic stress produces changes in the input-output relationship in the hippocampal trisynaptic circuit which could affect information flow through this structure...
  22. ncbi Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1
    Jannic Boehm
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Neuron 51:213-25. 2006
    ..We conclude that the phosphorylation of GluR1 S818 by PKC is a critical event in the plasticity-driven synaptic incorporation of AMPA receptors...
  23. ncbi Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression
    Neal Lemon
    Learning and Memory Research, Medical Faculty, and International Graduate School for Neuroscience, Ruhr University Bochum, 44780 Bochum, Germany
    J Neurosci 26:7723-9. 2006
    ..These findings suggest that the dopaminergic system, acting via D1/D5 receptors, gates long-term changes in synaptic strength and that these changes are a critical factor in the acquisition of novel information...
  24. ncbi Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons
    Heng Ye Man
    Brain and Behavior Program and Department of Pathology, Research Institute of the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Neuron 38:611-24. 2003
    ....
  25. ncbi D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus
    Noelia Granado
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Cereb Cortex 18:1-12. 2008
    ..These results indicate that D(1)R but not D(5)R are critical for hippocampal LTP and for the induction of Zif268 and Arc, proteins required for the transition from E-LTP to L-LTP and for memory consolidation in mammals...
  26. ncbi Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo
    Yugo Fukazawa
    Mitsubishi Kagaku Institute of Life Sciences MITILS, Machida, 194 8511, Tokyo, Japan
    Neuron 38:447-60. 2003
    ..These observations suggest that mechanisms regulating the spine actin cytoskeleton contribute to the persistence of LTP...
  27. pmc PKM zeta maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors
    Yudong Yao
    The Robert F Furchgott Center for Neural and Behavioral Science, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA
    J Neurosci 28:7820-7. 2008
    ..Thus, PKMzeta maintains late-LTP by persistently modifying NSF/GluR2-dependent AMPAR trafficking to favor receptor insertion into postsynaptic sites...
  28. ncbi Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress: implications for hippocampus-dependent learning
    Thomas Blank
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, D 37075 Goettingen, Germany
    J Neurosci 22:3788-94. 2002
    ..This observation suggests that priming of PS-LTP and activation of CaMKII represent two essential mechanisms that may contribute independently to long-term memory...
  29. ncbi NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation
    E Shimizu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Science 290:1170-4. 2000
    ..Such a synaptic reinforcement process may also serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage...
  30. pmc Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation
    Christopher S Rex
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA
    J Cell Biol 186:85-97. 2009
    ..Thus, LTP induction initiates two synaptic signaling cascades: one (RhoA-ROCK-cofilin) leads to actin polymerization, whereas the other (Rac-PAK) stabilizes the newly formed filaments...
  31. ncbi Hippocampal long-term depression: master or minion in declarative memory processes?
    Anne Kemp
    Learning and Memory Research, Medical Faculty, Ruhr University Bochum, Universitatsstrasse 150, MABF 01 551, 44780 Bochum, Germany
    Trends Neurosci 30:111-8. 2007
    ..Accumulating evidence supports the idea that LTP and LTD enable distinct and separate forms of information storage, which together facilitate the generation of a spatial cognitive map...
  32. ncbi Enhanced LTP in mice deficient in the AMPA receptor GluR2
    Z Jia
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Neuron 17:945-56. 1996
    ..Mutant mice exhibited increased mortality, and those surviving showed reduced exploration and impaired motor coordination. These results suggest an important role for GluR2 in regulating synaptic plasticity and behavior...
  33. ncbi Calcium/calmodulin-dependent protein kinase II contributes to activity-dependent filopodia growth and spine formation
    Pascal Jourdain
    Neuropharmacology, University Medical Center, University of Geneva, 1211 Geneva 4, Switzerland
    J Neurosci 23:10645-9. 2003
    ..Together, these results support the interpretation that CaMKII contributes to the control of activity-dependent structural plasticity...
  34. ncbi Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
    Jianyong Chen
    Department of Neurobiology and Behavior, Center for Neurobiology of Learning and Memory, University of California, Irvine, California 92697 3800, USA
    J Biol Chem 281:11910-6. 2006
    ..Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation...
  35. ncbi Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
    Christoph Schmidt-Hieber
    Physiologisches Institut der Universität Freiburg, D 79104 Freiburg, Germany
    Nature 429:184-7. 2004
    ..Thus, newly generated neurons express unique mechanisms to facilitate synaptic plasticity, which may be important for the formation of new memories...
  36. ncbi Conservation of total synaptic weight through balanced synaptic depression and potentiation
    Sebastien Royer
    Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Avenue, Newark, New Jersey 07102, USA
    Nature 422:518-22. 2003
    ..Thus, in intercalated neurons at least, inverse heterosynaptic plasticity tends to compensate for homosynaptic long-term potentiation and depression, thus stabilizing total synaptic weight...
  37. ncbi Long-term potentiation--a decade of progress?
    R C Malenka
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA
    Science 285:1870-4. 1999
    ..This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory...
  38. ncbi Weak before strong: dissociating synaptic tagging and plasticity-factor accounts of late-LTP
    U Frey
    Leibniz Institute for Neurobiology, Magdeburg, Germany
    Neuropharmacology 37:545-52. 1998
    ..These findings uphold a key prediction of the synaptic tag hypothesis and have implications for the functional role of synaptic tagging for cortical plasticity...
  39. pmc Bistability in the Ca(2+)/calmodulin-dependent protein kinase-phosphatase system
    A M Zhabotinsky
    Department of Chemistry and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Biophys J 79:2211-21. 2000
    ..They also suggest a plausible explanation for the very high concentrations of CaMKII found in postsynaptic densities of cerebral neurons...
  40. pmc Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
    Koji Yashiro
    Department of Cell and Molecular Physiology, Neuroscience Center, and Neurobiology Curriculum, University of North Carolina, Neuroscience Research Building, Campus Box 7545, 115 Mason Farm Road, Chapel Hill, NC 27599 7545, USA
    Neuropharmacology 55:1081-94. 2008
    ..Finally, we use the visual cortex as a model system to illustrate how activity-dependent modifications in the NR2A/NR2B ratio may contribute to the development of cortical functions...
  41. pmc Graded bidirectional synaptic plasticity is composed of switch-like unitary events
    Daniel H O'Connor
    Department of Molecular Biology and Program in Neuroscience, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 102:9679-84. 2005
    ..Under naïve conditions, approximately three-fourths of synapses began in a low-strength state. The timing of these unitary events can account for the time course of macroscopic synaptic plasticity...
  42. ncbi Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation
    Carl Weitlauf
    Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 25:8386-90. 2005
    ..Furthermore, our data demonstrate that care must be exercised in the interpretation of data generated with AAM077 when the compound is applied before an agonist...
  43. ncbi Learning induces long-term potentiation in the hippocampus
    Jonathan R Whitlock
    Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 313:1093-7. 2006
    ..Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1...
  44. ncbi Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD
    Sreedharan Sajikumar
    Department for Neurophysiology, Leibniz Institute for Neurobiology, Brenneckestr 6, D 39118 Magdeburg, Germany
    Neurobiol Learn Mem 82:12-25. 2004
    ..We name this new associative property of cellular information processing 'cross-tagging.'..
  45. ncbi A direct demonstration of cortical LTP in humans: a combined TMS/EEG study
    S K Esser
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Brain Res Bull 69:86-94. 2006
    ..A topographic analysis revealed that this potentiation was significant at EEG electrodes located bilaterally over premotor cortex. Thus, these findings provide a direct demonstration in humans of LTP induced by rTMS...
  46. ncbi Long-term potentiation and memory
    M A Lynch
    Trinity College Institute of Neuroscience, Department of Physiology, Trinity College, Dublin, Ireland
    Physiol Rev 84:87-136. 2004
    ....
  47. ncbi Activity and plasticity in the CA1, the dentate gyrus, and the amygdala following controllable vs. uncontrollable water stress
    Alexandra Kavushansky
    Department of Psychology and Brain and Behavior Research Center, University of Haifa, Israel
    Hippocampus 16:35-42. 2006
    ..These findings provide insight into the differential effects of stress and stress controllability on different hippocampal subregions and the amygdala...
  48. ncbi Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning
    D Zamanillo
    Department of Molecular Neuroscience, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Science 284:1805-11. 1999
    ..The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory...
  49. pmc Novel translational control in Arc-dependent long term potentiation consolidation in vivo
    Debabrata Panja
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    J Biol Chem 284:31498-511. 2009
    ..We examined translational control across the critical period of Arc synthesis underlying consolidation of long term potentiation (LTP) in the dentate gyrus of intact, anesthetized rats...
  50. ncbi Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning
    K P Giese
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 279:870-3. 1998
    ..Thus, the autophosphorylation of alphaCaMKII at Thr286 appears to be required for LTP and learning...
  51. pmc Neurofibromin regulation of ERK signaling modulates GABA release and learning
    Yijun Cui
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 135:549-60. 2008
    ..Importantly, our results also revealed lasting increases in GABA release triggered by learning, indicating that the mechanisms uncovered here are of general importance for learning...
  52. ncbi The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory
    D M Bannerman
    Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, England
    Psychopharmacology (Berl) 188:552-66. 2006
    ..The aim of this article is to provide a review of studies using N-methyl-D-aspartate (NMDA) receptor antagonists to assess the hippocampal long-term potentiation (LTP)/learning hypothesis...
  53. ncbi Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R)
    F N Single
    Max Planck Institute for Medical Research, Departments of Molecular Neuroscience and Cell Physiology, Jahnstrabetae 29, D 69120 Heidelberg, Germany
    J Neurosci 20:2558-66. 2000
    ..We conclude that disturbed NMDA receptor signaling mediates a variety of neurological phenotypes...
  54. ncbi The MeCP2-null mouse hippocampus displays altered basal inhibitory rhythms and is prone to hyperexcitability
    Liang Zhang
    Division of Fundamental Neurobiology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
    Hippocampus 18:294-309. 2008
    ..Taken together, our data indicate that the Mecp2-null hippocampal CA3 circuit has diminished basal inhibitory rhythmic activity, which in turn renders the circuitry prone to hyperexcitability...
  55. pmc Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex
    Megumi Kaneko
    Department of Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143 0444, USA
    Neuron 58:673-80. 2008
    ....
  56. ncbi Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
    R Bourtchuladze
    Cold Spring Harbor Laboratory, New York 11724
    Cell 79:59-68. 1994
    ..However, paired-pulse facilitation and posttetanic potentiation are normal. These results implicate CREB-dependent transcription in mammalian long-term memory...
  57. ncbi Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS
    Alexander Fleischmann
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    J Neurosci 23:9116-22. 2003
    ..In summary, our data suggest a role for c-Fos in hippocampus-dependent learning and memory as well as in NMDA receptor-dependent LTP formation...
  58. ncbi Synaptic plasticity and addiction
    Julie A Kauer
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Nat Rev Neurosci 8:844-58. 2007
    ..Reversing or preventing these drug-induced synaptic modifications may prove beneficial in the treatment of one of society's most intractable health problems...
  59. ncbi Changes in synaptic morphology accompany actin signaling during LTP
    Lulu Y Chen
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 4292, USA
    J Neurosci 27:5363-72. 2007
    ....
  60. pmc Spinophilin regulates the formation and function of dendritic spines
    J Feng
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:9287-92. 2000
    ..In conclusion, spinophilin appears to be required for the regulation of the properties of dendritic spines...
  61. ncbi Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
    Lidong Liu
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 304:1021-4. 2004
    ..These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity...
  62. ncbi Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus
    Aine Kelly
    Trinity College Institute of Neuroscience, Department of Physiology, Dublin 2, Ireland
    J Biol Chem 278:19453-62. 2003
    ..It has recently been reported that intraperitoneal injection of LPS inhibited long term potentiation (LTP) in perforant path-granule cell synapses and that this effect was coupled with an increase in the ..
  63. ncbi Novel presynaptic mechanisms for coincidence detection in synaptic plasticity
    Ian Duguid
    Wolfson Institute for Biomedical Research and Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Opin Neurobiol 16:312-22. 2006
    ..Recent studies also indicate the existence of presynaptic coincidence detection that is independent of NMDA receptors, suggesting that such mechanisms have a widespread role in plasticity...
  64. ncbi Endogenous acetylcholine lowers the threshold for long-term potentiation induction in the CA1 area through muscarinic receptor activation: in vivo study
    Saak V Ovsepian
    Department of Pharmacology and Therapeutics, Biotechnology Building, Trinity College, Dublin 2, Ireland
    Eur J Neurosci 20:1267-75. 2004
    ....
  65. ncbi Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
    Y M Lu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Neurosci 17:5196-205. 1997
    ..This is consistent with the hypothesis that LTP in the CA1 region may underlie spatial learning and memory...
  66. ncbi Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus
    Olof Wiegert
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Learn Mem 13:110-3. 2006
    ..These data provide a biological substrate for the important behavioral observation that stress and corticosteroid hormones can facilitate learning and memory processes...
  67. ncbi Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
    K P Murphy
    Department of Pharmacology, Centre for Brain Repair, Parke Davis Neuroscience Research, Department of Experimental Psychology, University of Cambridge, CB2 1QJ, United Kingdom
    J Neurosci 20:5115-23. 2000
    ..The temporal and regional changes in synaptic plasticity within the hippocampus mirror the appearance of neuronal intranuclear inclusions, suggesting a relationship between polyglutamine aggregation and dysfunction...
  68. ncbi PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage
    Todd Charlton Sacktor
    The Robert F Furchgott Center for Neural and Behavioral Science, Departments of Physiology, Pharmacology, and Neurology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Prog Brain Res 169:27-40. 2008
    ..Similar results are found for conditioned taste aversion when the inhibitor is injected in the insular neocortex. Thus PKMzeta is the first molecule found to be a component of the long-term memory trace...
  69. ncbi Induction of synaptic long-term potentiation after opioid withdrawal
    Ruth Drdla
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria
    Science 325:207-10. 2009
    ..These findings provide a previously unrecognized target to selectively combat pro-nociceptive effects of opioids without compromising opioid analgesia...
  70. pmc eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell 129:195-206. 2007
    ..These findings highlight the importance of a single phosphorylation site in eIF2alpha as a key regulator of L-LTP and LTM formation...
  71. pmc Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition
    Anne Kemp
    Learning and Memory Research Group, International Graduate School for Neuroscience, Ruhr University Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Proc Natl Acad Sci U S A 101:8192-7. 2004
    ..We also found that no further LTD could be induced. These findings support a decisive role for LTD in the acquisition of object-place configuration and consolidate its candidacy as a learning mechanism...
  72. ncbi LTP maintenance and its protein synthesis-dependence
    Wickliffe C Abraham
    Department of Psychology, University of Otago, Box 56, 95 Union Street, Dunedin 9016, New Zealand
    Neurobiol Learn Mem 89:260-8. 2008
    ..However, we highlight areas of research that could be usefully conducted to further our understanding of the properties and protein synthesis-dependence of LTP...
  73. ncbi Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease
    V W S Kung
    Department of Physiology, Development and Neuroscience, Anatomy School, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Neuroscience 146:1571-80. 2007
    ..neuronal plasticity is also altered in the dorsolateral striatum of R6/2 mice, we compared long term potentiation (LTP) and long term depression (LTD) in striatal slices from R6/2 mice with that seen in slices from wild ..
  74. ncbi MAPK cascade signalling and synaptic plasticity
    Gareth M Thomas
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, PCTB 904, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Nat Rev Neurosci 5:173-83. 2004
  75. ncbi Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation
    Nikolai Otmakhov
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 24:9324-31. 2004
    ..cLTP produced a persistent increase in the PSD-associated pool of CaMKIIalpha. These results are consistent with the hypothesis that CaMKIIalpha accumulation at synapses is a memory trace of past synaptic activity...
  76. ncbi Central sensitization and LTP: do pain and memory share similar mechanisms?
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Trends Neurosci 26:696-705. 2003
    ....
  77. ncbi Electrical stimulation protocols for hippocampal synaptic plasticity and neuronal hyper-excitability: are they effective or relevant?
    Benedict C Albensi
    Dept of Pharmacology and Therapeutics, Univ of Manitoba, Canada
    Exp Neurol 204:1-13. 2007
    ..Here the effectiveness and physiological relevance of these electrical stimulation protocols are examined in situations involving memory encoding (e.g., LTP/LTD) and epileptiform activity...
  78. ncbi Synaptic plasticity and memory: an evaluation of the hypothesis
    S J Martin
    Department and Centre for Neuroscience, University of Edinburgh, United Kingdom
    Annu Rev Neurosci 23:649-711. 2000
    ..We conclude that a wealth of data supports the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency...
  79. ncbi Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons
    Xixi Chen
    Center for Learning and Memory, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 26:12143-51. 2006
    ..2 knock-out and wild-type neurons. Our results support the hypothesis that dendritic A-type K+ channels, composed of Kv4.2 subunits, regulate action potential backpropagation and the induction of specific forms of synaptic plasticity...
  80. ncbi The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function
    J T Henderson
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
    Neuron 32:1041-56. 2001
    ..Together, these data demonstrate that EphB2 plays an important role in regulating synaptic function...
  81. ncbi Recycling endosomes supply AMPA receptors for LTP
    Mikyoung Park
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Science 305:1972-5. 2004
    ..Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification...
  82. ncbi Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo
    R Sprengel
    Max Planck Institute for Medical Research, Department of Molecular Neuroscience, Heidelberg, Germany
    Cell 92:279-89. 1998
    ..C-terminal truncation of NR2 subunits does not interfere with the formation of gateable receptor channels that can be synaptically activated. Thus, the phenotypes of our mutants appear to reflect defective intracellular signaling...
  83. ncbi Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation
    A Matilla
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 18:5508-16. 1998
    ..These findings demonstrate that SCA1 is not caused by loss of function of ataxin-1 and point to the possible role of ataxin-1 in learning and memory...
  84. ncbi Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices
    C Pavlides
    Rockefeller University, New York, NY 10021, USA
    Brain Res 738:229-35. 1996
    ..The present results are in agreement with previous studies showing that elevations in corticosterone or an acute episode of experimentally induced stress in vivo causes a suppression in LTP in the hippocampal CA1 field, in vitro...
  85. ncbi A developmental switch in the signaling cascades for LTP induction
    Hiroki Yasuda
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine, Stanford, California 94304, USA
    Nat Neurosci 6:15-6. 2003
    ....
  86. ncbi Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:8506-12. 2003
    ....
  87. ncbi Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice
    Fabrizio Trinchese
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    Ann Neurol 55:801-14. 2004
    ..In contrast, progression of LTP impairment correlated with the deterioration of working memory, suggesting that percentage of potentiation might be an indicator of the cognitive decline and disease progression in the APP/PS1 mice...
  88. ncbi Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit
    K Sakimura
    Department of Neuropharmacology, Niigata University, Japan
    Nature 373:151-5. 1995
    ..The mutant mice also showed a moderate deficiency in spatial learning. These results support the notion that the NMDA receptor channel-dependent synaptic plasticity is the cellular basis of certain forms of learning...
  89. ncbi Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo
    Karin Wibrand
    Department of Biomedicine and Bergen Mental Health Research Center, Section for Physiology, University of Bergen, Jonas Liens vei 91, N 5009 Bergen, Norway
    Eur J Neurosci 23:1501-11. 2006
    ..These results provide novel insight into gene expression responses underlying BDNF-induced synaptic consolidation in the adult brain in vivo...
  90. pmc Locally dynamic synaptic learning rules in pyramidal neuron dendrites
    Christopher D Harvey
    Janelia Farm Research Campus, HHMI, Ashburn, Virginia 20147, USA
    Nature 450:1195-200. 2007
    ..These local interactions between neighbouring synapses support clustered plasticity models of memory storage and could allow for the binding of behaviourally linked information on the same dendritic branch...
  91. ncbi Psychological stress impairs spatial working memory: relevance to electrophysiological studies of hippocampal function
    D M Diamond
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
    Behav Neurosci 110:661-72. 1996
    ..Stress appears to induce a transient disruption of hippocampal function, which is revealed behaviorally as retrograde amnesia and physiologically as a blockade of synaptic plasticity...
  92. pmc The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome
    Jesse E Hanson
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 5345, USA
    J Physiol 579:53-67. 2007
    ....
  93. ncbi Effects of inescapable stress on LTP in the amygdala versus the dentate gyrus of freely behaving rats
    Rose Marie Vouimba
    Department of Psychology, and the Brain and Behaviour Research Center, University of Haifa, 31905, Israel
    Eur J Neurosci 19:1887-94. 2004
    ..These data support a role for B in memory storage. Furthermore, they support a differential involvement of the amygdala and hippocampus in memory formation and storage depending on the emotional characteristics of the experience...
  94. ncbi Enhanced proliferation of progenitor cells following long-term potentiation induction in the rat dentate gyrus
    Sung Kun Chun
    Neuroscience Laboratory, Institute for Medical Sciences, Ajou University School of Medicine, Suwon 443 721, Republic of Korea
    Neurobiol Learn Mem 86:322-9. 2006
    ..Our results show that tetanic stimulation of perforant path sufficient to induce LTP increases progenitor proliferation in adult DG in an NMDA receptor-dependent manner...
  95. ncbi Molecular psychology: roles for the ERK MAP kinase cascade in memory
    J Paige Adams
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Pharmacol Toxicol 42:135-63. 2002
    ....
  96. ncbi Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors
    John F MacDonald
    Department of Physiology, Medical Sciences Building, 1 King s College, University of Toronto, Toronto Ontario M5S1A8, Canada
    Crit Rev Neurobiol 18:71-84. 2006
    ....
  97. ncbi Synaptic plasticity: taming the beast
    L F Abbott
    Department of Biology and Volen Center, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Nat Neurosci 3:1178-83. 2000
    ..We review three of them-synaptic scaling, spike-timing dependent plasticity and synaptic redistribution-and discuss their functional implications...
  98. ncbi Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation
    Susana S Correia
    Department of Pharmacology, University of Michigan Medical School, 1150 W Medical Center Dr, Ann Arbor, Michigan 48109 0632, USA
    Nat Neurosci 11:457-66. 2008
    ..In summary, we identified the specific motor protein and organelle acceptor that catalyze the directional transport of AMPARs into spines during activity-dependent synaptic plasticity...
  99. pmc Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation
    Katja Stefan
    Department of Neurology, University of Rostock, D 18157 Rostock, Germany
    J Physiol 543:699-708. 2002
    ..Together, these findings support the view that LTP-like mechanisms may underlie the cortical plasticity induced by IPAS...
  100. pmc Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
    Ruth Drdla
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Mol Pain 4:18. 2008
    ..These pathways match those leading to hyperalgesia in behaving animals and humans. We thus propose that LTP induced by low-level activity in C-fibres may underlie some forms of hyperalgesia...
  101. ncbi Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons
    Lars Jørgen Rygh
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 24:761-72. 2006
    ..Our results support the suggestion that the generation of LTP in dorsal horn neurons following peripheral injury may be one mechanism whereby acute pain can be transformed into a long-term pain state...

Research Grants68

  1. Regulation of AKAP79 Postsynaptic Membrane Targeting
    MARK L DELL'ACQUA; Fiscal Year: 2012
    ..AMPARs are recruited to dendritic spines through NMDAR activation during induction of long term potentiation (LTP) in hippocampal neurons through pathways that also increase spine size and actin polymerization...
  2. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..Aim 2. What is the effect of CSR on spatial learning and memory (water maze), and on long term potentiation (LTP;a measure of synaptic plasticity important for memory formation)...
  3. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    ..The results should significantly increase our understanding of the pathophysiology of M-D, which can ultimately aid the development of therapeutic treatments for M-D patients and other dystonia and myoclonus patients. ..
  4. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ....
  5. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013
    ..Thus, in Aims 2 and 3 I will pursue whether E2 recruits the dopaminergic system through an increase in dopamine release from noradrenergic terminals or through an increase in post-synaptic D1R activation. ..
  6. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..These studies would allow us to compare the different and overlapping targets of these two paralogous HATs, and help in the understanding of activity-dependent gene activation in the neuron during memory storage. ..
  7. Human VGF Polymorphisms and Depression
    Stephen R Salton; Fiscal Year: 2010
    ..conditioning and spatial memory, as well as in the regulation of synaptic plasticity and the induction of long term potentiation (LTP)...
  8. SK channels: Roles and mechanisms for dendritic excitability and plasticity
    James G Maylie; Fiscal Year: 2012
    ..In Shaffer collateral CA3 to CA1 synapses, long term potentiation (LTP), an activity-dependent increase in synaptic strength, has largely been attributed to increased ..
  9. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen M Harris; Fiscal Year: 2013
    ..Investigative tools will be improved to measure core subcellular structures regulate synaptic load, especially during long-term potentiation, a well-studied cellular mechanism of learning and memory. ..
  10. Novel neurotrophic therapy in a mouse model of ALS
    Alpaslan Dedeoglu; Fiscal Year: 2013
    ..The novel studies we propose will produce data to improve our understanding of disease mechanisms and test the beneficial effects of 7,8-DHF in ALS. ..
  11. Reactive Oxygen Species Signaling in the Hippocampus
    Eric Klann; Fiscal Year: 2012
    ..abstract_text> ..
  12. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen M Harris; Fiscal Year: 2010
    ....
  13. Role of Gprotein and SNAP-25 in NMDA vs mGluR presynaptic long-term plasticity
    KATISHA ROSE GOPAUL; Fiscal Year: 2013
    ....
  14. Neuroanatomical and functional outcomes of pediatric obstructive sleep apnea
    Robert Joseph Thomas; Fiscal Year: 2012
    ..g., dorsolateral prefrontal, posterior parietal, anterior cingulate) will be explored in relation to neuropsychological performance, neuroanatomical abnormalities, functional imaging abnormalities, and polysomnographic disease severity. ..
  15. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
    ..Studies will also test potential therapeutics for correcting these synaptic defects that might improve learning in this syndrome and other autism spectrum disorders. ..
  16. SK2 Channels as Novel Neuroprotective Targets Against Cerebral Ischemia
    Paco S Herson; Fiscal Year: 2012
    ..channels are removed from synapses following patterned activity, either normally as for the induction of long term potentiation (LTP), or abnormally after CA/CPR...
  17. Genome maintenance functions of CREB/ATF transcription factors
    RANDAL SCOT TIBBETTS; Fiscal Year: 2013
    ....
  18. Elucidating the role of the eIF2alpha kinase PERK in synaptic plasticity and memo
    MY AI TRINH; Fiscal Year: 2010
    ....
  19. Control of AMPA receptor function by phosphorylation
    Stephen F Traynelis; Fiscal Year: 2013
    ....
  20. Regulation of AKAP79 Postsynaptic Targeting and Signaling
    MARK L DELL'ACQUA; Fiscal Year: 2013
    ....
  21. STRESS-OPIOID INTERACTION IN HIPPOCAMPUS
    Teresa A Milner; Fiscal Year: 2013
    ..abstract_text> ..
  22. Cortical Synapses and Psychosis in AD
    Robert A Sweet; Fiscal Year: 2012
    ..Machine and electronic shops, housed in Crawford Hall, are available for the Translational Neuroscience Program faculty's use. ..
  23. Dietary targeting of dihydrolipoamide dehydrogenase for stroke tolerance
    Liang Jun Yan; Fiscal Year: 2013
    ..It is expected that the successfully completed study will provide novel strategies using DLDH as a target for stroke therapeutics. ..
  24. Novel epigenetic mechanisms in neuronal development and cognitive function
    Jun Xu; Fiscal Year: 2013
    ..Taken together, the proposed studies will provide significant new insights into epigenetic mechanisms that control cognitive function and behavior, and, when go awry, cause debilitating human diseases such as MR. ..
  25. Cortactin and Spine Dysfunction in Fragile X
    RONALD ROBERT SEESE; Fiscal Year: 2013
    ....
  26. Assessing the effects of Synj1 haploinsufficiency in Alzheimer's disease models
    Gilbert Di Paolo; Fiscal Year: 2010
    ..The goal of this proposal is to assess whether genetically decreasing the catabolism of PtdIns(4,5)P2 in the brain of AD mouse models can ameliorate learning and memory deficits in various behavioral tasks. ..
  27. Intrinsic plasticity and information storage in cerebellar Purkinje cells
    CHRISTIAN ROBERT HANSEL; Fiscal Year: 2012
    ....
  28. Hippocampal dendritic spines tracked in learning and memory processing using in v
    Mark J Schnitzer; Fiscal Year: 2012
    ....
  29. PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSION
    Patric K Stanton; Fiscal Year: 2012
    ..The long-term regulation of transmitter release has far-reaching importance to normal synaptic processing dynamics, and controlling pathologic glutamate release during injury or disease. ..
  30. Disease Mechanisms in Human Ubiquilinopathy
    Teepu Siddique; Fiscal Year: 2013
    ..In addition, cognitive and behavioral deficits and decreased long term potentiation in far field recordings were observed in transgenic mice expressing a pathogenic UBQLN2 mutation (P497H)...
  31. Sp4 Pathway in the Modulation of Sensorimotor Gating and Memory
    XIANJIN ZHOU; Fiscal Year: 2013
    ....
  32. Pharmacokinetic and pharmacodynamic optimization of soluble Abeta oligomer recept
    Susan M Catalano; Fiscal Year: 2012
    ..synaptotoxic Abeta oligomers alter glutamate receptor trafficking to the plasma membrane and inhibit long term potentiation, resulting in transient regression of spines, synapse loss and memory deficits (reviewed in Catalano et al...
  33. Validating a Novel Lipid Phosphatase Target in Alzheimer's Disease
    Tae Wan Kim; Fiscal Year: 2013
    ..Completion of these studies will determine if Synj1 can be a valid target for future AD therapeutic strategies. ..
  34. AKAP Regulation of Neuronal L-type Calcium Channel Signaling to the Nucleus
    MARK L DELL'ACQUA; Fiscal Year: 2013
    ....
  35. Regulation and Neural Function of Atypical PKC
    Todd C Sacktor; Fiscal Year: 2011
    ..This application is to characterize the functional mechanisms by which PKM6 maintains long-term information at synapses and during behavioral memory storage. ..
  36. BDNF and Spine-Realted Disorders of Memory and Cognition
    Christine M Gall; Fiscal Year: 2013
    ..In all, the proposed studies are expected to test for the presence of a final, common defect in memory disorders and to thoroughly evaluate a clinically relevant strategy for normalizing synaptic plasticity and behavior. ..
  37. Genetic Basis of Failed Cognition in Young and Aged Mouse Models of Trisomy 21
    Eugene Yu; Fiscal Year: 2013
    ....
  38. Role of Presenilins in the Synapse
    Jie Shen; Fiscal Year: 2013
    ..Completion of our proposed study will provide insights into AD pathogenesis and may identify novel therapeutic targets for development of new drugs. ..
  39. FETAL AND POSTNATAL DEVELOPMENT OF VISUAL CONNECTIONS
    Carla J Shatz; Fiscal Year: 2013
    ..They represent key steps in understanding mechanisms of developmental critical periods, as well as for designing new ways to enhance CNS function and repair by engaging the brain's inherent capacity for neural plasticity. ..
  40. CRCNS: PKMzeta-Dependent Protein Synthesis Maintains Synaptic Plasticity
    HAREL ZEEV SHOUVAL; Fiscal Year: 2013
    ..We are eager to extend this type of outreach to the domain of the interaction between theory and experiment in biological sciences. ..
  41. The Role of DNA Demethylation by Gadd45b in Memory and Synaptic Plasticity
    FARAZ ALI SULTAN; Fiscal Year: 2013
    ..The proposed study is designed to investigate the breadth of the ethological, physiological and molecular role of DNA demethylation in further detail. ..
  42. Mechanisms of nicotine-induced neuroplasticity
    Katumi Sumikawa; Fiscal Year: 2013
    ..Results from this study will likely lead to a better understanding of addiction processes and may aid in developing therapies for preventing the relapse, and thereby promoting smoking cessation. ..
  43. NMDA Receptors in Primary Afferents
    James A McRoberts; Fiscal Year: 2013
    ..Using rodent models, we will test the predictions that neuropathic and visceral pain increase NMDA-induced SP release, and decrease after selective knockdown of NMDARs in primary afferents. ..
  44. Myeloid cells, aging and the metabolic syndrome
    Richard M Ransohoff; Fiscal Year: 2013
    ....
  45. CELLULAR SUBSTRATES OF CEREBELLAR INFORMATION STORAGE
    David J Linden; Fiscal Year: 2010
    ..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally...
  46. Targeting Mitochondrial Superoxide in Angelman Syndrome
    Eric Klann; Fiscal Year: 2012
    ....
  47. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA F BRAGA; Fiscal Year: 2013
    ..Including a section of the particularly vulnerable population, and will result in the development of new compounds that will reduce mortality and morbidity during and after an emergency event involving nerve agents. ..
  48. Functional Characterization of synaptic calcium/calmodulin kinase II (CaMKII) acc
    Jacqueline K Rose; Fiscal Year: 2010
    ....
  49. Regulation of Local BDNF Synthesis in Dendrites
    Baoji Xu; Fiscal Year: 2010
    ..This research will make a significant contribution to the understanding of fragile X syndrome. ..
  50. Development and Plasticity of a Retinotectal System
    Mu ming Poo; Fiscal Year: 2012
    ..Results from the proposed studies will shed light on the mechanisms underlying normal neural circuit development and the potential causes of malformation of neural circuits during development. ..
  51. Molecular Mechanisms of SSRI Action in Childhood and Adolescence
    FRANCIS SANG YONG LEE; Fiscal Year: 2010
    ..LTD), and to potentially reduce spine density and dendritic complexity, whereas mature BDNF promotes long term potentiation (LTP) and enhanced dendritic morphology...
  52. Maternal smoking and hippocampal circuits
    Katumi Sumikawa; Fiscal Year: 2010
    ....
  53. Characterization of the role of CpA methylation in neuronal plasticity
    Stavros Lomvardas; Fiscal Year: 2009
    ..Extensive research over the last three decades has demonstrated that long term potentiation is a process that requires enduring changes in gene expression...
  54. Metabolic Mechanisms of Functional Neuroprotection in Epileptic Brain
    Do Young Kim; Fiscal Year: 2013
    ..This proposal will explore a potential molecular mechanism through which ketone bodies might exert such effects. ..
  55. Antihypertensive Effects of Tetanic Baraoreceptor Input Stimulation
    Xiaorui Tang; Fiscal Year: 2011
    ..Positive results could open entirely new avenues for developing more efficient hypertension therapies;and provide an effective treatment for the many patients suffering from drug resistant hypertension. ..
  56. RGS proteins as novel integrators of G protein and MAPK signaling
    John R Hepler; Fiscal Year: 2013
    ..Impact: These studies will provide key insight about RGS14 as a novel regulator and integrator of neurotransmitter signaling events that modulate neuronal plasticity, learning and memory. ..
  57. Local Mechanisms Underlying Synaptic Plasticity
    Ashok N Hegde; Fiscal Year: 2012
    ..Protein degradation is abnormal in many diseases and disorders of the brain. This research could help explain the memory loss that occurs in brain diseases and memory loss that happens in old age. ..
  58. PGC-1alpha and GABAergic Dysfunction in Huntington Disease
    Rita Marie Cowell; Fiscal Year: 2013
    ..These studies will test whether transcriptional pathways that control mitochondrial function and calcium homeostasis in interneurons have potential as targets for treatment of patients with HD. ..
  59. HCN1 channels in hippocampal function and spatial memory
    Steven A Siegelbaum; Fiscal Year: 2012
    ..Such studies may validate the HCN1 channel as a potential target for novel therapies for epilepsy, age-related memory loss, major depression, schizophrenia and related diseases of hippocampal function. ..
  60. Novel Epigenetic Roles of the Proteasome in Long-term Synaptic Plasticity
    SVITLANA BACH; Fiscal Year: 2013
    ....
  61. Rehabilitation Strategies for Memory Dysfunction After Traumatic Brain Injury
    Coleen M Atkins; Fiscal Year: 2013
    ..This grant will identify the biochemical mechanisms that underlie learning and memory disabilities after TBI and investigate whether an FDA-approved drug can restore learning and memory functioning in the weeks to months after TBI. ..
  62. Functional Subdomain Organization of the Recycling Endosome
    David R Sheff; Fiscal Year: 2010
    ..Similarly, the neuronal AMPA receptor is stored in the RE for recruitment during long term potentiation. The RE is a convergence point for all of these pathways, and so faces a major challenge: how to rapidly ..
  63. MECHANISMS UNDERLYING ADRENAL STEROID MODULATION OF LTP
    Constantine Pavlides; Fiscal Year: 2000
    ..Understanding the mechanisms underlying their effects on synaptic plasticity will greatly enhance out understanding of how they may be involved in human disease. ..
  64. The effects of alcohol on cerebellar synaotic transmission and plasticity
    CHRISTIAN ROBERT HANSEL; Fiscal Year: 2010
    ....
  65. REGULATION OF SYNAPTIC TRANSMISSION
    Robert Zucker; Fiscal Year: 2002
    ....
  66. LTP AND SPATIAL LEARNING
    TIMOTHY TEYLER; Fiscal Year: 2002
    ..The drugs will also be given in combination. ..
  67. LONG-TERM DEPRESSION IN THE ADULT HIPPOCAMPUS
    THOMAS O DELL; Fiscal Year: 1999
    ..Moreover, understanding these processes will be important understanding, at the cellular level, how memory is impaired in pathological conditions such as Alzheimer's disease. ..
  68. ApoE and ApoE receptors in the molecular mechanisms of synapse formation
    HYANG HOE; Fiscal Year: 2009
    ....