neuronal plasticity


Summary: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.

Top Publications

  1. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
  2. ncbi LTP and LTD: an embarrassment of riches
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 44:5-21. 2004
  3. ncbi Emotion circuits in the brain
    J E Ledoux
    Center for Neural Science, New York University, New York 10003, USA
    Annu Rev Neurosci 23:155-84. 2000
  4. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
  5. pmc Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
    Juha Lauren
    Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 457:1128-32. 2009
  6. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
  7. ncbi Short-term synaptic plasticity
    Robert S Zucker
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 64:355-405. 2002
  8. pmc Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    Amar Sahay
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    Nature 472:466-70. 2011
  9. ncbi Experience-dependent structural synaptic plasticity in the mammalian brain
    Anthony Holtmaat
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Switzerland
    Nat Rev Neurosci 10:647-58. 2009
  10. ncbi Stress, depression, and neuroplasticity: a convergence of mechanisms
    Christopher Pittenger
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
    Neuropsychopharmacology 33:88-109. 2008

Detail Information

Publications324 found, 100 shown here

  1. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
  2. ncbi LTP and LTD: an embarrassment of riches
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 44:5-21. 2004
    ..Here we review those forms of LTP and LTD for which mechanisms have been most firmly established. Examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function...
  3. ncbi Emotion circuits in the brain
    J E Ledoux
    Center for Neural Science, New York University, New York 10003, USA
    Annu Rev Neurosci 23:155-84. 2000
    ..With so much research being done in this area today, it is important that the mistakes of the past not be made again. It is also time to expand from this foundation into broader aspects of mind and behavior...
  4. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
    ..Therefore, the local cortical network structure can be viewed as a skeleton of stronger connections in a sea of weaker ones. Such a skeleton is likely to play an important role in network dynamics and should be investigated further...
  5. pmc Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
    Juha Lauren
    Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 457:1128-32. 2009
    ..Thus, PrP(C) is a mediator of amyloid-beta-oligomer-induced synaptic dysfunction, and PrP(C)-specific pharmaceuticals may have therapeutic potential for Alzheimer's disease...
  6. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
    ..The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life...
  7. ncbi Short-term synaptic plasticity
    Robert S Zucker
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 64:355-405. 2002
    ..Finally, we summarize the recent literature on putative molecular players in synaptic plasticity and the effects of genetic manipulations and other modulatory influences...
  8. pmc Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    Amar Sahay
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    Nature 472:466-70. 2011
  9. ncbi Experience-dependent structural synaptic plasticity in the mammalian brain
    Anthony Holtmaat
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Switzerland
    Nat Rev Neurosci 10:647-58. 2009
    ..This Review focuses on recent evidence for such structural forms of synaptic plasticity in the mammalian cortex and outlines open questions...
  10. ncbi Stress, depression, and neuroplasticity: a convergence of mechanisms
    Christopher Pittenger
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
    Neuropsychopharmacology 33:88-109. 2008
    ..Greater appreciation of the convergence of mechanisms between stress, depression, and neuroplasticity is likely to lead to the identification of novel targets for more efficacious treatments...
  11. pmc Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
    Hsiao Tuan Chao
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 468:263-9. 2010
    ..These data demonstrate that MeCP2 is critical for normal function of GABA-releasing neurons and that subtle dysfunction of GABAergic neurons contributes to numerous neuropsychiatric phenotypes...
  12. pmc Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
    ..They further suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long-term memory...
  13. pmc Arc-dependent synapse-specific homeostatic plasticity
    Jean Claude Beique
    The Solomon Snyder Department of Neuroscience, Johns Hopkins University, USA
    Proc Natl Acad Sci U S A 108:816-21. 2011
    ..Together, our results document an extra level of regulation of synaptic function that bears important computational consequences on information storage in the brain...
  14. ncbi Regeneration beyond the glial scar
    Jerry Silver
    Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Neurosci 5:146-56. 2004
  15. pmc Correction of fragile X syndrome in mice
    Gul Dolen
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 56:955-62. 2007
    ..Our results demonstrate that mGluR5 contributes significantly to the pathogenesis of the disease, a finding that has significant therapeutic implications for fragile X and related developmental disorders...
  16. pmc The self-tuning neuron: synaptic scaling of excitatory synapses
    Gina G Turrigiano
    Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Cell 135:422-35. 2008
    ..Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales...
  17. ncbi Neural consequences of environmental enrichment
    H van Praag
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Rev Neurosci 1:191-8. 2000
    b>Neuronal plasticity is a central theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in Drosophila to behavioural recovery from strokes in elderly humans...
  18. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
  19. pmc Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function
    Gary J Bassell
    Department of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuron 60:201-14. 2008
    ..The understanding of FMRP function at synapses has led to rationale therapeutic approaches...
  20. pmc mTOR signaling: at the crossroads of plasticity, memory and disease
    Charles A Hoeffer
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Trends Neurosci 33:67-75. 2010
    ..Finally, perturbation of the mTOR signaling cascade appears to be a common pathophysiological feature of human neurological disorders, including mental retardation syndromes and autism spectrum disorders...
  21. ncbi Local sleep and learning
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nature 430:78-81. 2004
    ..Furthermore, we show that the local increase in SWA after learning correlates with improved performance of the task after sleep. Thus, sleep homeostasis can be induced on a local level and can benefit performance...
  22. ncbi Theta burst stimulation of the human motor cortex
    Ying Zu Huang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuron 45:201-6. 2005
  23. ncbi Polychronization: computation with spikes
    Eugene M Izhikevich
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Neural Comput 18:245-82. 2006
  24. ncbi The organization of recent and remote memories
    Paul W Frankland
    Program in Integrative Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1XB
    Nat Rev Neurosci 6:119-30. 2005
    ..However, recent studies have begun to shed light on how remote memories are organized in the cortex, and the molecular and cellular events that underlie their consolidation...
  25. ncbi Control of synaptic strength by glial TNFalpha
    Eric C Beattie
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Science 295:2282-5. 2002
    ..Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury...
  26. ncbi MAPK cascade signalling and synaptic plasticity
    Gareth M Thomas
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, PCTB 904, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Nat Rev Neurosci 5:173-83. 2004
  27. ncbi Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
    Joshua T Trachtenberg
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nature 420:788-94. 2002
    ..Our measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits...
  28. pmc Neuroplasticity subserving motor skill learning
    Eran Dayan
    Human Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Neuron 72:443-54. 2011
  29. ncbi Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity
    Alexey Harauzov
    Scuola Normale Superiore, 56126 Pisa, Italy
    J Neurosci 30:361-71. 2010
    ..Thus, intracortical inhibition is a crucial limiting factor for the induction of experience-dependent plasticity in the adult visual cortex...
  30. ncbi Critical period plasticity in local cortical circuits
    Takao K Hensch
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Nat Rev Neurosci 6:877-88. 2005
    ..The reactivation of this process, and subsequent recovery of function in conditions such as amblyopia, can now be studied with realistic circuit models that might generalize across systems...
  31. ncbi Connectivity reflects coding: a model of voltage-based STDP with homeostasis
    Claudia Clopath
    Laboratory of Computational Neuroscience, Brain Mind Institute and School of Computer and Communication Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Nat Neurosci 13:344-52. 2010
    ..Thus, variable connectivity patterns in the brain could reflect different coding principles across brain areas; moreover, our simulations suggested that plasticity is fast...
  32. ncbi Stably maintained dendritic spines are associated with lifelong memories
    Guang Yang
    Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    Nature 462:920-4. 2009
    ..These studies indicate that learning and daily sensory experience leave minute but permanent marks on cortical connections and suggest that lifelong memories are stored in largely stably connected synaptic networks...
  33. ncbi The antidepressant fluoxetine restores plasticity in the adult visual cortex
    José Fernando Maya Vetencourt
    Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
    Science 320:385-8. 2008
    We investigated whether fluoxetine, a widely prescribed medication for treatment of depression, restores neuronal plasticity in the adult visual system of the rat...
  34. ncbi Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
    ..Here we review progress in identifying candidate mechanisms of addiction...
  35. pmc Unraveling mechanisms of homeostatic synaptic plasticity
    Karine Pozo
    MRC Cell Biology Unit and MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Neuron 66:337-51. 2010
    ..Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity...
  36. pmc Rapid formation and selective stabilization of synapses for enduring motor memories
    Tonghui Xu
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    Nature 462:915-9. 2009
    ..Our findings reveal that rapid, but long-lasting, synaptic reorganization is closely associated with motor learning. The data also suggest that stabilized neuronal connections are the foundation of durable motor memory...
  37. ncbi Dendritic protein synthesis, synaptic plasticity, and memory
    Michael A Sutton
    Division of Biology 114 96, California Institute of Technology, Howard Hughes Medical Institute, Pasadena, CA 91125, USA
    Cell 127:49-58. 2006
    ..Here, we review the experimental support for this idea and highlight some of the key questions outstanding in this area...
  38. ncbi Recovery of learning and memory is associated with chromatin remodelling
    Andre Fischer
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 447:178-82. 2007
  39. pmc Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke
    Andrew N Clarkson
    Department of Neurology, The David Geffen School of Medicine at UCLA, 635 Charles Young Drive South, Los Angeles, California 90095, USA
    Nature 468:305-9. 2010
    ..Together, our results identify new pharmacological targets and provide the rationale for a novel strategy to promote recovery after stroke and possibly other brain injuries...
  40. ncbi The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 119:873-87. 2004
    ..Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites...
  41. pmc Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo
    Aaron S Nudelman
    Department of Pharmacology, University of Washington, Seattle, Washington
    Hippocampus 20:492-8. 2010
    ..We conclude that miR-132 is an activity-dependent microRNA in vivo, and may contribute to the long-lasting proteomic changes required for experience-dependent neuronal plasticity.
  42. pmc Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    Ganesh M Shankar
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 14:837-42. 2008
    ..We conclude that soluble Abeta oligomers extracted from Alzheimer's disease brains potently impair synapse structure and function and that dimers are the smallest synaptotoxic species...
  43. ncbi Long-term depression in the CNS
    Graham L Collingridge
    Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Nat Rev Neurosci 11:459-73. 2010
    ..In addition, LTD may underlie the cognitive effects of acute stress, the addictive potential of some drugs of abuse and the elimination of synapses in neurodegenerative diseases...
  44. pmc Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
    Moustapha Cisse
    Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
    Nature 469:47-52. 2011
    ..Thus, depletion of EphB2 is critical in amyloid-β-induced neuronal dysfunction. Increasing EphB2 levels or function could be beneficial in Alzheimer's disease...
  45. pmc Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
    Michael D Saxe
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17501-6. 2006
    ..These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior...
  46. ncbi Synaptic plasticity and dysconnection in schizophrenia
    Klaas E Stephan
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Biol Psychiatry 59:929-39. 2006
    ..Promising experimental paradigms include perceptual and reinforcement learning. We describe how theoretical and causal models of brain responses might contribute to a mechanistic understanding of synaptic plasticity in schizophrenia...
  47. pmc The immediate early gene arc/arg3.1: regulation, mechanisms, and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
    J Neurosci 28:11760-7. 2008
    ..its transcriptional and translational regulation, the functions of the Arc protein in multiple forms of neuronal plasticity [long-term potentiation (LTP), long-term depression (LTD), and homeostatic plasticity], and its broader ..
  48. ncbi Reactivation of ocular dominance plasticity in the adult visual cortex
    Tommaso Pizzorusso
    Scuola Normale Superiore, 56100 Pisa, Italy
    Science 298:1248-51. 2002
    ..The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity...
  49. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  50. ncbi Experience-dependent structural plasticity in the adult human brain
    Arne May
    Department of Systems Neuroscience, University Clinic Hamburg Eppendorf UKE, D 20246 Hamburg, Germany
    Trends Cogn Sci 15:475-82. 2011
    ..Understanding normative changes in brain structure that occur as a result of environmental changes and demands is pivotal to understanding the characteristic ability of the brain to adapt...
  51. ncbi The mystery and magic of glia: a perspective on their roles in health and disease
    Ben A Barres
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 60:430-40. 2008
    ..I argue that until the roles of nonneuronal cells are more fully understood and considered, neurobiology as a whole will progress only slowly...
  52. pmc Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity
    Sylvain Chauvette
    The Centre de Recherche Institut Universitaire en Santé Mentale de Québec CRIUSMQ, Laval University, Quebec, QC G1J 2G3, Canada
    Neuron 75:1105-13. 2012
    ..Our results suggest that long-term potentiation occurs during slow-wave sleep, supporting its contribution to memory...
  53. pmc Functional specialization for auditory-spatial processing in the occipital cortex of congenitally blind humans
    Olivier Collignon
    Centre de Recherche en Neuropsychologie et Cognition, Universite de Montreal, Montreal, QC, Canada H3C 3J7
    Proc Natl Acad Sci U S A 108:4435-40. 2011
  54. ncbi Neurotrophins as synaptic modulators
    M M Poo
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    Nat Rev Neurosci 2:24-32. 2001
    ..By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections...
  55. pmc Experience-dependent structural plasticity in the cortex
    Min Fu
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Trends Neurosci 34:177-87. 2011
    ..Therefore, circuit plasticity, mediated by structural remodeling, provides an underlying mechanism for learning and memory...
  56. pmc Lynx1, a cholinergic brake, limits plasticity in adult visual cortex
    Hirofumi Morishita
    FM Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Science 330:1238-40. 2010
    ..The results suggest that modulating the balance between excitatory and inhibitory circuits reactivates visual plasticity and may present a therapeutic target...
  57. ncbi The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    J Z Tsien
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1327-38. 1996
    ..Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories...
  58. pmc An epigenetic blockade of cognitive functions in the neurodegenerating brain
    Johannes Graff
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 483:222-6. 2012
    ..These findings advocate for the development of selective inhibitors of histone deacetylase 2 and suggest that cognitive capacities following neurodegeneration are not entirely lost, but merely impaired by this epigenetic blockade...
  59. ncbi Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    Jorge J Palop
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 55:697-711. 2007
    ..Aberrant increases in network excitability and compensatory inhibitory mechanisms in the hippocampus may contribute to Abeta-induced neurological deficits in hAPP mice and, possibly, also in humans with AD...
  60. ncbi The synapsins: key actors of synapse function and plasticity
    F Cesca
    Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, Via Morego 30, 16163 Genova, Italy
    Prog Neurobiol 91:313-48. 2010
    ..and functioning of neuronal networks, these proteins are extremely important in the fine-tuning of neuronal plasticity, as shown by the epileptic phenotype and behavioural abnormalities characterising mouse lines lacking one ..
  61. pmc Reversing pathological neural activity using targeted plasticity
    Navzer D Engineer
    Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, USA
    Nature 470:101-4. 2011
    ..These improvements persisted for weeks after the end of therapy. This method for restoring neural activity to normal may be applicable to a variety of neurological disorders...
  62. pmc Sleep and synaptic homeostasis: structural evidence in Drosophila
    Daniel Bushey
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Science 332:1576-81. 2011
    The functions of sleep remain elusive, but a strong link exists between sleep need and neuronal plasticity. We tested the hypothesis that plastic processes during wake lead to a net increase in synaptic strength and sleep is necessary ..
  63. ncbi Synaptic computation
    L F Abbott
    Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Nature 431:796-803. 2004
    ..By expressing several forms of synaptic plasticity, a single neuron can convey an array of different signals to the neural circuit in which it operates...
  64. pmc The Arc of synaptic memory
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Exp Brain Res 200:125-40. 2010
    ..Arc holds considerable promise as a "master regulator" of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated...
  65. pmc Local GABA circuit control of experience-dependent plasticity in developing visual cortex
    T K Hensch
    Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Science 282:1504-8. 1998
    ..Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development...
  66. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    ..These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation...
  67. pmc Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
    Daniela Puzzo
    Department of Pathology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    J Neurosci 28:14537-45. 2008
  68. pmc Glutamate and neurotrophic factors in neuronal plasticity and disease
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Ann N Y Acad Sci 1144:97-112. 2008
    ..By enhancing neurotrophic factor signaling, environmental factors such as exercise and dietary energy restriction, and chemicals such as antidepressants may optimize glutamatergic signaling and protect against neurological disorders...
  69. pmc Actin in dendritic spines: connecting dynamics to function
    Pirta Hotulainen
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Cell Biol 189:619-29. 2010
    ..Therefore, specific mechanisms of actin regulation are integral to the formation, maturation, and plasticity of dendritic spines and to learning and memory...
  70. ncbi NMDA receptor subunits: diversity, development and disease
    S Cull-Candy
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Opin Neurobiol 11:327-35. 2001
    ..Recent studies are beginning to address the functional significance of NMDAR diversity under normal and pathological conditions...
  71. pmc Functional requirement for class I MHC in CNS development and plasticity
    G S Huh
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Science 290:2155-9. 2000
    ..These results demonstrate an important role for these molecules in the activity-dependent remodeling and plasticity of connections in the developing and mature mammalian central nervous system (CNS)...
  72. ncbi Exercise: a behavioral intervention to enhance brain health and plasticity
    Carl W Cotman
    Institute for Brain Aging and Dementia, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4540, USA
    Trends Neurosci 25:295-301. 2002
    ..Thus, exercise could provide a simple means to maintain brain function and promote brain plasticity...
  73. pmc BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?
    Yuan Lu
    Gene, Cognition and Psychosis Program GCAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Neurobiol Learn Mem 89:312-23. 2008
    ..Finally, specific roles of BDNF in the acquisition, retention or extinction of LTM remain to be established...
  74. pmc Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity
    Jason Aoto
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720 3200, USA
    Neuron 60:308-20. 2008
    ..Together, our data suggest that RA functions in homeostatic plasticity as a signaling molecule that increases synaptic strength by a protein synthesis-dependent mechanism...
  75. ncbi BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
    Z J Huang
    Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 98:739-55. 1999
    ..We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity...
  76. ncbi Synaptic plasticity: multiple forms, functions, and mechanisms
    Ami Citri
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Neuropsychopharmacology 33:18-41. 2008
    ..We also provide examples of the possible developmental and behavioral functions of synaptic plasticity and how maladaptive synaptic plasticity may contribute to neuropsychiatric disorders...
  77. pmc An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
    Gary A Wayman
    Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:9093-8. 2008
    ..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity...
  78. ncbi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
    ..The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury...
  79. ncbi The stressed hippocampus, synaptic plasticity and lost memories
    Jeansok J Kim
    Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520 8205, USA
    Nat Rev Neurosci 3:453-62. 2002
    ..Here, we provide an overview of the neurobiology of stress memory interactions, and present a neural endocrine model to explain how stress modifies hippocampal functioning...
  80. ncbi The neuronal microRNA system
    Kenneth S Kosik
    Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Nat Rev Neurosci 7:911-20. 2006
    ..Nevertheless, the identification of such targets promises to provide new insights into many facets of neuronal function...
  81. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
    ..These findings provide a strategy by which individuals with spinal cord injuries could regain substantial levels of motor control...
  82. pmc Arc in synaptic plasticity: from gene to behavior
    Erica Korb
    Gladstone Institute of Neurological Disease, San Francisco, CA, USA
    Trends Neurosci 34:591-8. 2011
    ..We will also attempt to clarify how its molecular functions correspond to its requirement in various forms of plasticity, discuss Arc's role in behavior and disease, and highlight critical unresolved questions...
  83. ncbi Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    Shoshanna Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eur J Neurosci 20:2580-90. 2004
    ..These findings suggest a functional role for CREB under the control of BDNF in mediating the exercise-induced enhancement in learning and memory. Our results indicate that synapsin I might also contribute to this BDNF-mediated mechanism...
  84. pmc Sleep and synaptic renormalization: a computational study
    Umberto Olcese
    Perceptual Robots Laboratory, Scuola Superiore Sant Anna, Pisa, Italy
    J Neurophysiol 104:3476-93. 2010
  85. ncbi Motor learning: its relevance to stroke recovery and neurorehabilitation
    John W Krakauer
    Stroke and Critical Care Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York NY, USA
    Curr Opin Neurol 19:84-90. 2006
    ..questions: (i) What is motor learning? (ii) Do patients with hemiparesis have a learning deficit? (iii) Is recovery after injury a form of motor learning? (iv) Are approaches based on motor learning principles useful for rehabilitation?..
  86. ncbi The amygdala and persistent pain
    Volker Neugebauer
    Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, 77555 1069, USA
    Neuroscientist 10:221-34. 2004
    ..It is conceivable, however, that amygdala plasticity plays an important role in emotional pain behavior and its modulation by affective state...
  87. ncbi Neuronal signalling of fear memory
    Stephen Maren
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Neurosci 5:844-52. 2004
    ..Understanding the signalling of aversive memory by amygdala neurons opens new avenues for research into the neural systems that support fear behaviour...
  88. ncbi Stress and hippocampal plasticity
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Annu Rev Neurosci 22:105-22. 1999
    ..It is important, from a therapeutic standpoint, to distinguish between a permanent loss of cells and a reversible atrophy...
  89. ncbi Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:9598-611. 2004
  90. ncbi Multiple roles of calcium ions in the regulation of neurotransmitter release
    Erwin Neher
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 59:861-72. 2008
    ..Such coupling is essential for rendering vesicles sensitive to short [Ca(2+)] transients, generated during action potentials...
  91. ncbi Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
    Daniela Carulli
    Cambridge University Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge, CB2 0PY, UK
    Brain 133:2331-47. 2010
    ..The organization of chondroitin sulphate proteoglycan into perineuronal nets is therefore the key event in the control of central nervous system plasticity by the extracellular matrix...
  92. ncbi New views of Arc, a master regulator of synaptic plasticity
    Jason D Shepherd
    Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 14:279-84. 2011
  93. ncbi Structural dynamics of dendritic spines in memory and cognition
    Haruo Kasai
    Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, and Center for NanoBio Integration, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Trends Neurosci 33:121-9. 2010
    ..Thus, spine dynamics are cellular phenomena with important implications for cognition and memory. Furthermore, impaired spine dynamics can cause psychiatric and neurodevelopmental disorders...
  94. ncbi Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
    Ajai Vyas
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 22:6810-8. 2002
    ..Thus, stress-induced structural plasticity in amygdala neurons may provide a candidate cellular substrate for affective disorders triggered by chronic stress...
  95. ncbi The neural basis of perceptual learning
    C D Gilbert
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 31:681-97. 2001
    ..Top-down control of these representations suggests that learning involves an interaction between multiple cortical areas...
  96. ncbi Visualizing an olfactory sensory map
    P Mombaerts
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute and Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 87:675-86. 1996
    ..This genetic approach may be more broadly applied to visualize the development and plasticity of projections in the mammalian nervous system...
  97. pmc Superresolution imaging of chemical synapses in the brain
    Adish Dani
    Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Neuron 68:843-56. 2010
    ..Combination with optogenetics further allowed molecular events associated with synaptic plasticity to be resolved at the single-synapse level...
  98. pmc Transcription factors in long-term memory and synaptic plasticity
    Cristina M Alberini
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Physiol Rev 89:121-45. 2009
    ..The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation...
  99. ncbi Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    Gerd Kempermann
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Ann Neurol 52:135-43. 2002
    ..Activity exerts not only an acute but also a sustained effect on brain plasticity...
  100. ncbi Astrocytes potentiate transmitter release at single hippocampal synapses
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Science 317:1083-6. 2007
    ..This persistent plasticity was mGluR-mediated but N-methyl-d-aspartate receptor-independent. These results indicate that astrocytes are actively involved in the transfer and storage of synaptic information...
  101. ncbi Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
    Lorenzo A Cingolani
    MRC Laboratory for Molecular Cell Biology and MRC Cell Biology Unit, University College London, Gower Street, London, WC1E 6BT, UK
    Nat Rev Neurosci 9:344-56. 2008
    ..The aim of this Review is to highlight some of the recent progress in elucidating the role of the actin cytoskeleton in synaptic function...

Research Grants76

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..More importantly, neuronal plasticity during adolescence may still allow reversibility of disease-related brain effects through teaching coping ..
  2. Role of AIE in Epigenetic and Behavioral Changes at Adulthood
    Subhash C Pandey; Fiscal Year: 2013
    ..The link between epigenetic mechanisms and neuronal plasticity associated with adaptational mechanisms to adolescent intermittent ethanol (AIE) exposure and its role in ..
  3. miR132 regulation of neuronal plasticity, learning, and memory
    KATELIN L F HANSEN; Fiscal Year: 2013
    Inducible gene expression plays a central role in neuronal plasticity, learning, and memory. Dysregulation of these processes can lead to severe neuronal disorders and cognitive impairment...
  4. Cell Models for Alzheimer's disease (AD): Lipids and Related Signaling Pathways
    Grace Y Sun; Fiscal Year: 2012
    ..The decreased neuronal plasticity and cognitive memory loss found in people with AD is associated with chronic oxidative stress and increased ..
  5. Pioglitazone & Exercise Effects on Older Aldults with MCI and Metabolic Syndrome
    Robert S Schwartz; Fiscal Year: 2010 1) improving central adiposity and IR;2) improving vascular reactivity;or 3) increased exercise-induced neuronal plasticity, through enhancing brain-derived neurotrophic factor (BNDF) We propose a double-blinded (drug), placebo-..
  6. Metabolic &Developmental Aspects of Intellectual Disability
    Mary C McKenna; Fiscal Year: 2013
    ..interactions and function of the LI cell adhesion molecule, a key protein involved in neurite outgrowth, neuronal plasticity, and signal transduction pathways...
    Nigel W Bunnett; Fiscal Year: 2010
    ..regulate neurons will provide new insights into the general mechanisms by which inflammation shapes neuronal plasticity to cause dysfunction and disease, and may lead to new therapies to control neuronal hypersensitivity, ..
    Rae Silver; Fiscal Year: 2010
    ..behavioral circadian rhythms;2) the phenotype of AR-containing cells in the SCN;3) androgen effects on SCN neuronal plasticity, 4) clock gene expression and 5) electrophysiological responses of AR-containing and rhythmic Per-..
  9. Mapping DNA methylation in hippocampal neurons through bisulfite sequencing
    Guoping Fan; Fiscal Year: 2012
    ..mechanism for the development and function of the nervous system, ranging from cell differentiation to neuronal plasticity and from learning &memory to behavior...
    Charles W Emala; Fiscal Year: 2013
    ..amino acids;molecular mechanisms of opioid addiction, tolerance and withdrawal;molecular mechanisms of neuronal plasticity in chronic pain;structure/function of ligand gated ion channels;anesthetic and alcohol modulation of gene ..
  11. Olfactory Adaptation in C. Elegans
    NOELLE D L 'ETOILE; Fiscal Year: 2013
    ..elegans to determine whether a small RNA regulatory pathway directs stimulus-specific neuronal plasticity. One means by which repeated stimulation alters neuronal responsiveness is via the changes in transcription ..
  12. Neurobiology of Anxiety and Panic Disorders
    Anantha Shekhar; Fiscal Year: 2013
    ..disinhibition of ORX neurons in the DMH/PeF enhances excitation and reduces inhibition, thus facilitating neuronal plasticity in the CeA...
  13. HLA and schizophrenia: a high-throughput sequencing study
    ..cases, and are related to auto-immune processes, infection, and/or the role of MHC Class I loci in neuronal plasticity. It is therefore critical to dissect the effects ofHLA variants on schizophrenia risk...
  14. Neurohumoral adaptations to chronic intermittent hypoxia
    Steven W Mifflin; Fiscal Year: 2012
    ..The studies will determine mechanisms that mediate neuronal plasticity and are important in the development of CIH-hypertension...
    Michael D Gershon; Fiscal Year: 2012
    ..the relative importance of mucosal or neuronal sources of 5-HT in enteric neuroprotection, neurogenesis, neuronal plasticity and inflammation...
  16. Effects of traumatic brain injury on hippocampal network activity: age difference
    Susanna Rosi; Fiscal Year: 2013
    ..on brain metabolism, hippocampal vulnerability;these pathophysiological factors might ultimately alter neuronal plasticity and cause memory deficits...
  17. Brain epigenetic mechanisms in alcohol dependence
    SUBHASH PANDEY; Fiscal Year: 2009
    ..It has been shown that phosphorylated cAMP-responsive element binding (p-CREB) regulates neuronal plasticity via recruitment of the HAT associated with CREB binding protein (CBP) to activate gene transcription...
  18. Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC2
    Madhavan P Nair; Fiscal Year: 2013
    ..the progression of HAND;2) whether inhibition of HDAC2 reverses the effects of cocaine and HIV-1 virus on neuronal plasticity genes and dendritic spine density and 3) can delivery of HDAC2 specific siRNA and miR-155 across the in ..
  19. Activity-dependent microRNA expression and function in the mature nervous system
    Karl H Obrietan; Fiscal Year: 2013
    ..microRNA expression patterns in the mature nervous system and, importantly, whether microRNA regulate neuronal plasticity and cell viability...
    Berislav V Zlokovic; Fiscal Year: 2013
    ..mutant, is neuroprotective and promotes brain regeneration after ischemic/thrombotic stroke by modifying neuronal plasticity, vascular remodeling and stroke-induced neurogenesis through PAR1, EPCR and S1P1 on BEC, and PAR1, PAR3 and ..
  21. Meninges-to-astrocyte communication in cognitive function
    Jonathan Kipnis; Fiscal Year: 2013
    ..In addition, T cells play an important role in neuronal plasticity, an essential substrate for spatial learning and memory...
  22. Oxytocin and Oxytocin Neurons in the Hypothalamic Regulation of Feeding
    Bassil M Kublaoui; Fiscal Year: 2012
    ..feeding regulation by the hypothalamus, or that Oxt is important but that compensatory mechanisms such as neuronal plasticity contribute to normalizing food intake in Oxt-/- mice...
  23. Genetic Regulation of Complex Neurological Diseases
    Wayne N Frankel; Fiscal Year: 2013
    ..In parallel, we will explore whether CELF4 has a coordinating role in shaping cellular responses by examining mutant cell culture, acute brain slice and whole animal models of neuronal plasticity.
  24. Mechanisms of retinal angiogenesis
    Gadiparthi N Rao; Fiscal Year: 2013
    ..of stimulants, including cytokines, growth factors and hormones and is involved in the regulation of neuronal plasticity, long-term memory and cellular metabolism...
  25. Role of calcium-dependent mechanisms in nicotine's tolerance and effects
    MOHAMAD IMAD DAMAJ; Fiscal Year: 2010 particular Ca2+calmodulin-dependent protein kinase II (CaMKII), are known to play an important role in neuronal plasticity and are therefore attractive candidates for contributing to neuronal adaptation leading to nicotine ..
  26. Regulation of Tyrosine Hydroxylase by CLOCK: Potential Mechanisms Underlying the
    WILBUR PUTNEY WILLIAMS; Fiscal Year: 2013
    ..binding protein (pCREB), the principle driver of TH transcription and is widely implicated in mediating the neuronal plasticity associated with addiction...
    Isabella Garcia; Fiscal Year: 2013 the mammalian brain represents an extraordinary example of continued cellular and structural neuronal plasticity. Although the phenomenology of this process has been well established, the molecular and genetic mechanisms ..
  28. Hypothalamic Neuronal Plasticity in Chronic Stress
    De Pei Li; Fiscal Year: 2013
    ..Also, these findings may lead to the development of novel therapies to prevent and treat psychiatric diseases such as depression. ..
  29. GABA(A) Receptor Assembly/Trafficking/Function and Epilepsy Missense Mutations
    ROBERT LOUDEN MACDONALD; Fiscal Year: 2013
    ..In addition and to, characterize the adaptive neuronal plasticity that occurs in response to the loss of inhibition for each mutation...
  30. Mechanisms Underlying Stress Resilience
    Janice H Urban; Fiscal Year: 2013
    ..The identification of the HCN channels as potential targets of neuronal plasticity in this model of induced resilience is exciting and such information is crucial for the development of ..
  31. The regulation of cannabinoid receptors in microglial cells during HIV infection
    CATALIN FILIPEANU; Fiscal Year: 2012
    ..9-tetrahydrocannabinol (THC) has many other biological actions including modulation of the immune response, neuronal plasticity and food intake...
  32. Neuronal dysfunction caused by Abeta inhibition of MT motors
    Huntington Potter; Fiscal Year: 2013 applicant): Microtubule (MT) dysfunction, neurotoxicity, chromosome mis-segregation, and defective neuronal plasticity are all induced by A[unreadable] peptide and implicated in Alzheimer's disease (AD) pathogenesis...
  33. Characterization of the role of CpA methylation in neuronal plasticity
    Stavros Lomvardas; Fiscal Year: 2009
    ..irreversible modification that can enhance, or modulate gene expression could have profound consequences in neuronal plasticity. Therefore, we propose experiments that will dissect the role of CpA methylation in gene expression and ..
    David J Linden; Fiscal Year: 2013
    ..Determining the molecular basis of these forms of neuronal plasticity will provide the fundamental understanding necessary to provide therapies for diseases of memory as well as ..
  35. Mints: Adaptor Proteins Coupling APP of Alzheimer's Disease to the Synapse
    Angela Ho; Fiscal Year: 2010
    ..My long-term goal is to pursue my understanding of molecular mechanisms underlying neuronal plasticity, and neurodegenerative diseases integrating the tools and conceptual approaches that I have learned and ..
  36. RGS proteins as novel integrators of G protein and MAPK signaling
    John R Hepler; Fiscal Year: 2013
    ..Impact: These studies will provide key insight about RGS14 as a novel regulator and integrator of neurotransmitter signaling events that modulate neuronal plasticity, learning and memory.
  37. Neuronal Changes in Adult Rats Induced by Neonatal Pain
    Adrian Miranda; Fiscal Year: 2011
    ..The goal of this proposal is to investigate alterations in visceral sensation and underlying neuronal plasticity in the spinal cord that result from painful somatic stimulation early in development...
  38. A Quantitative Proteomics Platform to Characterize the Nicotine-Dependent Brain
    JOHN ROBERT YATES; Fiscal Year: 2010
    ..b>Neuronal plasticity is furthermore known to rely heavily on post-translational events that regulate protein structure and ..
  39. CD200 as a monocyte/macrophage switch for brain repair after stroke
    Kazuhide Hayakawa; Fiscal Year: 2013
    ..CD34+/Flk1+ cells and TLR4low/Flk1high M-theta in parallel with reducing massive gliosis and improving neuronal plasticity in peri-infarct cortex after cerebral ischemia in mice...
    Rosemarie M Booze; Fiscal Year: 2013
    ..changes with respect to regulators of nucleus accumbens medium spiny neurons and prefrontal cortical neuronal plasticity. The ultimate goal of this research is to identify sensitive targets and unique pharmacological ..
  41. The role of hypocretin neurons in cocaine reinforcement
    Xiao Bing Gao; Fiscal Year: 2011
    ..We have demonstrated that neuronal plasticity in hypocretin neurons underlies energy homeostasis and sleep regulation, which has been published in high- ..
  42. TBI-induced Synaptic Plasticity: Effects on Ethanol Sensitivity
    Alana C Conti; Fiscal Year: 2012
    ..and synaptic modification have indicated that TBI is capable of inhibiting anatomical manifestations of neuronal plasticity. Importantly, evidence of disrupted dendritic structure has also been demonstrated in rats with altered ..
  43. Metabolic and Epigenetic Regulation of Genes Controlling Neuronal Plasticity
    Avtar S Roopra; Fiscal Year: 2013 from my lab suggests that perturbation of energy metabolism may represent a novel route to controlling neuronal plasticity (Garriga-Canut et al, 2006)...
  44. Small Molecule Libraries Targeted to CBP and Attenuation AfosB Expression
    Ming Ming Zhou; Fiscal Year: 2013
    ..These involve, in part, a subversion, or hijacking of normal neuronal plasticity associated reward, memory and learning...
  45. Glial-cytokine-neuronal interactions in the mechanisms of persistent pain
    Ke Ren; Fiscal Year: 2012
    ..We hypothesize that 1) peripheral inflammation induces neuronal plasticity in the RVM circuitry involving activation of glia;and 2) RVM glial activation and inflammatory cytokine ..
  46. D1 Dopamine Receptor Signaling and Cocaine Reinstatement
    ..CaM-KII is a critical link between nucleus accumbens shell dopamine and glutamate systems involved in the neuronal plasticity underlying cocaine priming-induced reinstatement of drug seeking in rats...
  47. Prefrontal Cortex BDNF and Amygdala-Dependent Emotional LearningChallenge Area:
    Kerry J Ressler; Fiscal Year: 2010
    ..may be brain derived neurotrophic factor (BDNF), a neurotrophin that is well known to be involved in neuronal plasticity and has been shown to be involved in learning, including fear and appetitive conditioning and extinction...
  48. Homeostatic Plasticity in Nucleus Accumbens
    MARINA ELIZABETH WOLF; Fiscal Year: 2013
    ..This suggests the involvement of homeostatic rather than Hebbian forms of neuronal plasticity. Using a mouse model, this proposal aims to determine the role of homeostatic plasticity in the nucleus ..
    Paul F Worley; Fiscal Year: 2012 transcriptionally up-regulated in brain neurons in response to patterns of synaptic activity that evoke neuronal plasticity. Our broad goal is to understand how pentraxins contribute to neural plasticity, and thereby reveal new ..
  50. Epigenetics of neuronal plasticity in auditory cortex in a sensory memory model
    Kerry J Ressler; Fiscal Year: 2013
  51. Immunotherapy to Improve Functional Outcomes after Chronic Stoke in the Aged
    GWENDOLYN LOUISE KARTJE; Fiscal Year: 2012
    ..We now plan to study the ability of anti-Nogo-A immunotherapy to enhance functional recovery and neuronal plasticity in the chronic stroke impaired rat...
  52. Regulating BDNF Action in Postnatal Development.
    Barbara L Hempstead; Fiscal Year: 2013
    ..regulate intracellular trafficking to dendrites or axons are critical to modulate structural and functional neuronal plasticity. We have developed new genetic tools to facilitate detection of endogenous BDNF, and identified new sorting ..
  53. Differentially expressed hippocampal miRNAs with age and cognitive decline
    Colleen A Van Kirk; Fiscal Year: 2013
    ..and Aged Cognitively Impaired rats we have identified a number of changes in protein expression related to neuronal plasticity that are not regulated at the transcript level...
  54. Epigenetic memory of plant stress response
    Se Young Kim; Fiscal Year: 2010
    ..For example, the basis of memory formation lies with neuronal plasticity, wherein biochemical and structural changes, mediated through epigenetic control, facilitate adaptation...
  55. Mechanisms of dendritic exocytosis
    Matthew Kennedy; Fiscal Year: 2013
    ..these independent but complementary aims will greatly advance our understanding of fundamental forms of neuronal plasticity and inform future efforts in determining how and why plasticity is disrupted in numerous neuropsychiatric ..
  56. ChemR23 agonists for pain and inflammation
    Miguel Garcia-Guzman; Fiscal Year: 2011
    ..activate ChemR23 G-protein coupled receptors to induce analgesia, ameliorate inflammation, and reverse neuronal plasticity associated with chronic pain presents a unique opportunity to develop therapies with transformational ..
  57. Homeostatic Regulation and Dysregulation in Cocaine Craving
    Yan Dong; Fiscal Year: 2013
    ..This suggests the involvement of homeostatic rather than Hebbian forms of neuronal plasticity. Using rats, we propose to determine the role of homeostatic plasticity in the NAc in the incubation of ..
  58. Reduced TrkB and BACE1 Elevation: Potential Link in Alzheimer's Pathogenesis
    Masuo Ohno; Fiscal Year: 2013
    ..neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) play a crucial role in neuronal plasticity and survival...
  59. Effect of Killing or Removing GABA from NPY/AgRP Neurons
    Richard D Palmiter; Fiscal Year: 2013
    ..This research is relevant to a better understanding normal and addictive feeding behavior, neuronal plasticity, and diseases such as anorexia nervosa.
  60. Regulating Mitochondrial Fission for Arrhythmia Prevention
    Fadi Gabriel Akar; Fiscal Year: 2013
    ..changes, caused by complex fusion and fission events, are essential for embryonic development, neuronal plasticity, apoptosis, and calcium signaling...
  61. Cognitive Recovery and Neuronal Plasticity after Stroke in the Aged
    REBECCA LYNN GILLANI; Fiscal Year: 2010
    ..pyramidal cells, and layer V pyramidal cells) of Golgi-Cox processed brains will be examined for structural neuronal plasticity by quantification of dendritic arborization, spine density, and spine morphology...
  62. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian-Smith; Fiscal Year: 2012
    ..Our current and proposed studies focus on examining factors that impede or promote the recovery of hand function, and our findings will enable the development of more effective treatments of cervical nerve and spinal injury ..
    Michael Miller; Fiscal Year: 1999
    ..Both NGF and acetylcholine are essential for maintaining neuronal plasticity. We hypothesize that the ethanol-induced memory loss results from losses in neuronal plasticity...
  64. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
  65. Applications of FES Artificial Walking for Cerebral Palsy
    Jessica Rose; Fiscal Year: 2009
    ..More effective treatment for gait deficits in CP is needed at an early age when there is optimal neuronal plasticity, rapid musculoskeletal growth and a greater likelihood of preventing gait abnormalities...
    MARINA WOLF; Fiscal Year: 2001
    ..This is an important question, because glutamate systems are likely to mediate the neuronal plasticity underlying the transition from drug experimentation to drug dependency...
  67. Genomic Approaches to Neuronal Diversity and Plasticity
    Jingyue Ju; Fiscal Year: 2007
    ..pattern of interconnections, which underlie behavior and, (3) the molecular basis of synapse-specific neuronal plasticity and neuronal growth...
  68. Target regulation of neuronal plasticity
    David Pettigrew; Fiscal Year: 2009
    Considerable progress has been made in identifying factors that play important roles in regulating neuronal plasticity, both during development and in maturity. The PI has been actively studying one example of such plasticity, i.e...
    KENNETH MC CARSON; Fiscal Year: 2004
    ..application by a new investigator addresses the molecular consequences of chronic pain and how pain-induced neuronal plasticity alters sensory processing...
  70. Molecular Profiling of Song Nucleus HVC in the Zebra Finch
    CLAUDIO MELLO; Fiscal Year: 2009
    ..vocal learning and communication, the action of sex hormones on the brain and behavior, seasonal and adult neuronal plasticity, and the discovery of continued neuronal replacement in the vertebrate brain...
  71. bZIP Repression of Adrenergic Receptor RNA in Neurons
    CURTIS MACHIDA; Fiscal Year: 2006
    ..Regulation of neurotransmitter receptor efficacy and control of neuronal plasticity, as evidenced in receptor desensitization and chronic down-regulation mechanisms, are recognized as part of ..
  72. ACC Sensitization in Visceral Hypersensitive Rats
    Chung Owyang; Fiscal Year: 2010
    ..that persistence of a heightened tonic visceral afferent nociceptive input to the ACC induces ACC neuronal plasticity characterized by an increase in synaptic transmission...
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
    EDSON ALBUQUERQUE; Fiscal Year: 1999
    ..NMDA receptors and alpha7-bearing nAChR are involved in memory and learning as well as in other forms of neuronal plasticity and development, it is very likely that inhibition of these receptors by Pb2+, particularly during early ..
  75. PKC-dependent GluR2 internalization in the spinal cord by persistent pain
    Yuan Xiang Tao; Fiscal Year: 2009
    ..GRIP and PICK1, may function in the synaptic AMPA receptor trafficking that is critical for many forms of neuronal plasticity. GRIP anchors GluR2 at synapses, whereas PICK1 brings PKC1 to synaptic GluR2...
  76. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN L KARTJE MD; Fiscal Year: 2010
    ..We have shown that anti-Nogo-A immunotherapy results in neuronal plasticity and functional recovery after ischemic stroke in adult rats...