neural conduction

Summary

Top Publications

  1. ncbi Amplitude, area and duration of the compound muscle action potential change in different ways over the length of the ulnar nerve
    B Johnsen
    Department of Clinical Neurophysiology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Clin Neurophysiol 117:2085-92. 2006
  2. ncbi Correlations of nerve conduction measures in axonal and demyelinating polyneuropathies
    Hatice Tankisi
    Department of Clinical Neurophysiology, Aarhus University Hospital, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Clin Neurophysiol 118:2383-92. 2007
  3. ncbi Ascorbic acid for Charcot-Marie-Tooth disease type 1A in children: a randomised, double-blind, placebo-controlled, safety and efficacy trial
    Joshua Burns
    Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, and Institute for Neuromuscular Research, Children s Hospital at Westmead, Sydney, NSW, Australia
    Lancet Neurol 8:537-44. 2009
  4. ncbi Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies
    V A Carozzi
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    Exp Neurol 226:301-9. 2010
  5. pmc Charcot-Marie-Tooth disease subtypes and genetic testing strategies
    Anita S D Saporta
    Department of Neurology, Wayne State University, Detroit, MI, USA
    Ann Neurol 69:22-33. 2011
  6. ncbi Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation
    J D England
    Neurology 64:199-207. 2005
  7. pmc Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study
    James W Albers
    Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diabetes Care 33:1090-6. 2010
  8. ncbi Prevalence of carpal tunnel syndrome in a general population
    I Atroshi
    Department of Orthopedics, Hässleholm Kristianstad Hospital, Sweden
    JAMA 282:153-8. 1999
  9. ncbi The spectrum of neuropathy in diabetes and impaired glucose tolerance
    C J Sumner
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 60:108-11. 2003
  10. ncbi Increased prevalence of impaired glucose tolerance in patients with painful sensory neuropathy
    J R Singleton
    Division of Neuromuscular Disease, Department of Neurology, University of Utah, Salt Lake City, Utah 84132, USA
    Diabetes Care 24:1448-53. 2001

Research Grants

  1. Surgical Management of Facial Nerve Injury
    Theresa Hadlock; Fiscal Year: 2007
  2. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2010
  3. Microgenomic Studies of ALS
    John Ravits; Fiscal Year: 2007
  4. PROSAPOSIN AND PROSAPTIDES IN DIABETIC NEUROPATHY
    NIGEL CALCUTT; Fiscal Year: 2002
  5. Carotid Body Chemoreception: Mechanism & Development
    DAVID DONNELLY; Fiscal Year: 2006
  6. Left-Right Asymmetry of the Developing Diecephalon
    Marnie E Halpern; Fiscal Year: 2013
  7. Spinal Cord-to-Computer Interface
    Mesut Sahin; Fiscal Year: 2013
  8. The Neurobiology of Auditory Perception in Autism
    Nicole Gage; Fiscal Year: 2006
  9. Network vasomotor response to tissue adenosine
    Richard Rivers; Fiscal Year: 2007
  10. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008

Detail Information

Publications284 found, 100 shown here

  1. ncbi Amplitude, area and duration of the compound muscle action potential change in different ways over the length of the ulnar nerve
    B Johnsen
    Department of Clinical Neurophysiology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Clin Neurophysiol 117:2085-92. 2006
    ..To study physiological changes of the compound muscle action potential (CMAP) obtained from stimulation at different sites over the full length of a motor nerve and to study possible effects of anthropometrical factors...
  2. ncbi Correlations of nerve conduction measures in axonal and demyelinating polyneuropathies
    Hatice Tankisi
    Department of Clinical Neurophysiology, Aarhus University Hospital, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Clin Neurophysiol 118:2383-92. 2007
    ....
  3. ncbi Ascorbic acid for Charcot-Marie-Tooth disease type 1A in children: a randomised, double-blind, placebo-controlled, safety and efficacy trial
    Joshua Burns
    Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, and Institute for Neuromuscular Research, Children s Hospital at Westmead, Sydney, NSW, Australia
    Lancet Neurol 8:537-44. 2009
    ..We tested the efficacy and safety of ascorbic acid supplementation in children with CMT1A...
  4. ncbi Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies
    V A Carozzi
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    Exp Neurol 226:301-9. 2010
    ..These results confirm the possibility to use our models to combine the study of the antineoplastic activity of anticancer drugs and of their toxic effects on the peripheral nervous system in the BALB/c mouse strain...
  5. pmc Charcot-Marie-Tooth disease subtypes and genetic testing strategies
    Anita S D Saporta
    Department of Neurology, Wayne State University, Detroit, MI, USA
    Ann Neurol 69:22-33. 2011
    ..Identifying the genetic cause of CMT is often necessary for family planning, natural history studies, and for entry into clinical trials. However genetic testing can be both expensive and confusing to patients and physicians...
  6. ncbi Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation
    J D England
    Neurology 64:199-207. 2005
    ..The inclusion of this formalized case definition in clinical and epidemiologic research studies will ensure greater consistency of case selection...
  7. pmc Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study
    James W Albers
    Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diabetes Care 33:1090-6. 2010
    ....
  8. ncbi Prevalence of carpal tunnel syndrome in a general population
    I Atroshi
    Department of Orthopedics, Hässleholm Kristianstad Hospital, Sweden
    JAMA 282:153-8. 1999
    ..Although high prevalence rates of CTS in certain occupations have been reported, little is known about its prevalence in the general population...
  9. ncbi The spectrum of neuropathy in diabetes and impaired glucose tolerance
    C J Sumner
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 60:108-11. 2003
    ..To compare the neuropathy associated with impaired glucose tolerance (IGT) and diabetes mellitus (DM) determined by oral glucose tolerance testing (OGTT)...
  10. ncbi Increased prevalence of impaired glucose tolerance in patients with painful sensory neuropathy
    J R Singleton
    Division of Neuromuscular Disease, Department of Neurology, University of Utah, Salt Lake City, Utah 84132, USA
    Diabetes Care 24:1448-53. 2001
    ....
  11. pmc Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial
    Peter J Dyck
    Peripheral Neuropathy Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 42:157-64. 2010
    ..Study physician dx from signs and symptoms were excessively variable, often overestimating DSPN. Specific approaches to improving clinical proficiency should be tested...
  12. pmc Functional trade-offs in white matter axonal scaling
    Samuel S H Wang
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Neurosci 28:4047-56. 2008
    ..The heterogeneous white matter composition found in large brains thus reflects a metabolically constrained trade-off that reduces both volume and conduction time...
  13. ncbi Maximum number of collaterals developed by one axon during peripheral nerve regeneration and the influence of that number on reinnervation effects
    Bao Guo Jiang
    Department of Orthopedics and Trauma, Peking University People s Hospital, Beijing, China
    Eur Neurol 58:12-20. 2007
    ..7 and 18.6 +/- 4.3 m/s, -80.2 +/- 7.1 and 12.7 +/- 3.7 m/s, and -85.4 +/- 5.7 and 10.5 +/- 3.9 m/s, respectively. It has been suggested that 1 axon can regenerate and maintain up to 3 or 4 collaterals in regenerated rat peripheral nerve...
  14. ncbi Acrolein induces myelin damage in mammalian spinal cord
    Yunzhou Shi
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Neurochem 117:554-64. 2011
    ..From this data, it is clear that acrolein is capable of inflicting myelin damage as well as axonal degeneration, and may represent an important factor in the pathogenesis in multiple sclerosis and spinal cord injury...
  15. ncbi Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function
    Suzhen Chen
    Division of Neuroscience, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3079-86. 2006
    ..These results suggest that disruption of the NRG1-erbB signaling pathway could contribute to the pathogenesis of peripheral neuropathies with hypomyelination and neuropathic pain...
  16. pmc Impaired neurovascular repair in subjects with diabetes following experimental intracutaneous axotomy
    Gigi J Ebenezer
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287 7609, USA
    Brain 134:1853-63. 2011
    ..These models are useful tools for the efficient investigation of neurotrophic and regenerative drugs, and also to explore factors that may differentially affect axonal regeneration...
  17. ncbi Evaluation of atrophy of foot muscles in diabetic neuropathy -- a comparative study of nerve conduction studies and ultrasonography
    Kaare Severinsen
    Department of Neurology, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Clin Neurophysiol 118:2172-5. 2007
    ..To evaluate the relation between the findings at nerve conduction studies and the size of small foot muscles determined by ultrasonography...
  18. pmc Nociceptors: a phylogenetic view
    Ewan St John Smith
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, 13125 Berlin Buch, Germany
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195:1089-106. 2009
    ..This review will focus on what is known about nociceptors throughout the Animalia kingdom and what similarities exist across phyla; especially at the molecular level of ion channels...
  19. pmc Modeling nerve conduction criteria for diagnosis of diabetic polyneuropathy
    Peter J Dyck
    Peripheral Neuropathy Research Laboratory, Department of Neurology Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 44:340-5. 2011
    ..In this study we aimed to determine which criteria are valid for nerve conduction (NC) diagnosis of typical diabetic sensorimotor polyneuropathy (DSPN)...
  20. ncbi Bridging small-gap peripheral nerve defects using biodegradable chitin conduits with cultured schwann and bone marrow stromal cells in rats
    Peixun Zhang
    Department of Orthopaedics and Trauma, Peking University People s Hospital, Beijing, China
    J Reconstr Microsurg 21:565-71. 2005
    ....
  21. ncbi Elevated glycosylated hemoglobin is associated with subclinical neuropathy in neurologically asymptomatic diabetic patients: a prospective study
    Khalid El-Salem
    Department of Neurosciences, Jordan University of Science and Technology, Irbid, Jordan
    J Clin Neurophysiol 26:50-3. 2009
    ..Therapies for diabetic neuropathy should target the early stages of the disease...
  22. ncbi Information processing in the axon
    Dominique Debanne
    Equipe INSERM AVENIR, Plasticité de l excitabilité neuronale, Neurobiologie des Canaux Ioniques INSERM U641, Institut Federatif de Recherche Jean Roche, Universite de la Mediterranee, Marseille, France
    Nat Rev Neurosci 5:304-16. 2004
  23. pmc Low peripheral nerve conduction velocities and amplitudes are strongly related to diabetic microvascular complications in type 1 diabetes: the EURODIAB Prospective Complications Study
    Morten Charles
    School of Public Health, Aarhus University, Aarhus, Denmark
    Diabetes Care 33:2648-53. 2010
    ..Because subjective or clinical indicators of neuropathy do not always match well with the presence of abnormal nerve physiology tests, we evaluated associations to nerve conduction in patients with type 1 diabetes...
  24. ncbi Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review
    Kate E Schemmel
    Mercy Medical Center, Dubuque, IA 52001, USA
    J Diabetes Complications 24:354-60. 2010
    ..The purpose of this article was to examine how aldose reductase (AR) inhibitors are used in the prevention and treatment of peripheral neuropathy in diabetes, specifically focusing on efficacy...
  25. pmc Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice
    Tatsuhito Himeno
    Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes 60:2397-406. 2011
    ..The therapeutic potential of exendin-4, an agonist of the glucagon-like peptide-1 receptor (GLP-1R), on diabetic polyneuropathy (DPN) in streptozotocin (STZ)-induced diabetic mice was investigated...
  26. ncbi A novel method of eliciting pain-related potentials by transcutaneous electrical stimulation
    Zaza Katsarava
    University of Essen, Department of Neurology, Germany
    Headache 46:1511-7. 2006
    ..These methods are, however, partly invasive, expensive, and therefore not available for broad clinical use. We recently proposed a novel technique of noninvasive transcutaneous electrical stimulation...
  27. ncbi An evaluation of gender, obesity, age and diabetes mellitus as risk factors for carpal tunnel syndrome
    Jefferson Becker
    Department of Clinical Neurophysiology, Hospital Luterano, Universidade Luterana do Brasil, RS, Porto Alegre, Brazil
    Clin Neurophysiol 113:1429-34. 2002
    ....
  28. ncbi Axonal ion channels from bench to bedside: a translational neuroscience perspective
    Arun V Krishnan
    Translational Neuroscience Facility, University of New South Wales, Randwick, Sydney, NSW, Australia
    Prog Neurobiol 89:288-313. 2009
    ....
  29. ncbi Reliability and validity of the CMT neuropathy score as a measure of disability
    M E Shy
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Neurology 64:1209-14. 2005
    ..To determine the validity and reliability of the Charcot-Marie-Tooth disease (CMT) neuropathy score (CMTNS) in patients with inherited neuropathy...
  30. pmc Carpal tunnel syndrome
    Somaiah Aroori
    Department of Surgery, Level 2, Belfast HSC Trust, Lisburn Road, Belfast BT9 7AB, United Kingdom
    Ulster Med J 77:6-17. 2008
    ..Apart from early recovery and return to work there is no significant difference in terms of early and late complications and long-term pain relief between endoscopic and open carpal tunnel surgery...
  31. ncbi Motor unit recruitment strategies investigated by surface EMG variables
    Dario Farina
    Centro di Bioingegneria, Department of Electronics, Politecnico di Torino, Torino 10129, Italy
    J Appl Physiol (1985) 92:235-47. 2002
    ..Our results do not support the establishment of a general relationship between spectral EMG variables and torque or recruitment strategy...
  32. ncbi Acute tetrodotoxin-induced neurotoxicity after ingestion of puffer fish
    Matthew C Kiernan
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney NSW 2031, Australia
    Ann Neurol 57:339-48. 2005
    ..It demonstrates the ability of noninvasive nerve excitability studies to detect Na(+) channel blockade in vivo and also the utility of mathematical modeling to aid interpretation of altered excitability properties in disease...
  33. ncbi A case-control study of obesity as a risk factor for carpal tunnel syndrome in a population of 600 patients presenting for independent medical examination
    S P Stallings
    Department of Surgery, University of Louisville School of Medicine, KY, USA
    J Hand Surg Am 22:211-5. 1997
    ..A statistically significant association was found between obesity and median neuropathy. The implications of such a relationship are discussed in light of the contemporary debate over the etiology of cumulative trauma disorders...
  34. ncbi Simple screening tests for peripheral neuropathy in the diabetes clinic
    B A Perkins
    Beth Israel Deaconness Medical Center and Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 24:250-6. 2001
    ..The reported operating characteristics for each sensory modality can be applied to positive findings on the physical examination of individual patients to predict the likelihood of neuropathy...
  35. ncbi A neurophysiological grading scale for carpal tunnel syndrome
    J D Bland
    Kent and Canterbury Hospital, Canterbury, Kent, England
    Muscle Nerve 23:1280-3. 2000
    ..5 ms; very severe (grade 5), terminal latency to APB > 6.5 ms; extremely severe (grade 6), sensory and motor potentials effectively unrecordable (surface motor potential from APB < 0.2 mV amplitude)...
  36. pmc Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions
    D G Flood
    Department of Molecular Biology, Cephalon, Inc, West Chester, Pennsylvania, USA
    Am J Pathol 155:663-72. 1999
    ..Therefore, Cu/Zn SOD is not required for normal motor neuron survival, but is necessary for the maintenance of normal neuromuscular junctions by hindlimb motor neurons...
  37. ncbi Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat
    X Chen
    Departments of Anatomy, Medicine, and Oral and Maxillofacial Surgery, Division of Neuroscience, NIH Pain Center (UCSF, University of California, San Francisco 94143-0440, USA
    Neuroscience 102:185-92. 2001
    ..The present findings suggest that study of individual neurons in vitro may allow elucidation of the ionic basis of enhanced nociception in diabetic neuropathy...
  38. pmc Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:234-42. 2005
    ..These findings reveal the new beneficial properties of fidarestat, thus further justifying the ongoing clinical trials of this specific, potent, and low-toxic ARI...
  39. ncbi Detection of small-fiber neuropathy by sudomotor testing
    Victoria A Low
    Department of Neurology, Mayo Clinic, Guggenheim 811, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 34:57-61. 2006
    ..Sudomotor examination is thus a highly sensitive detection tool in DSFN. Autonomic involvement is mainly distal, and additionally may involve adrenergic and the long cardiovagal fibers...
  40. ncbi Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair
    Christine Radtke
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Brain Res 1254:10-7. 2009
    ..Even a modest improvement in nerve regeneration could have significant clinical implications for reconstructive nerve surgery...
  41. ncbi Direct measurement of somatic voltage clamp errors in central neurons
    Stephen R Williams
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Neurosci 11:790-8. 2008
    ..These errors question the use of the somatic voltage clamp as a quantitative tool in dendritic neurons...
  42. ncbi Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability
    T Coetzee
    UNC Neuroscience Center, University of North Carolina at Chapel Hill 27599, USA
    Cell 86:209-19. 1996
    ..These results indicate that GalC and sulfatide play important roles in myelin function and stability...
  43. ncbi The effects of normal aging on myelin and nerve fibers: a review
    Alan Peters
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715, Albany Street, Boston, MA 02118, USA
    J Neurocytol 31:581-93. 2002
    ..Degeneration of myelin itself does not seem to result in microglial cells undertaking phagocytosis. These cells are probably only activated when large numbers of nerve fibers are lost, as can occur in the optic nerve...
  44. ncbi The natural history of Charcot-Marie-Tooth type 1A in adults: a 5-year follow-up study
    Camiel Verhamme
    Department of Neurology and Clinical Neurophysiology, H2 222, Academic Medical Centre, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Brain 132:3252-62. 2009
    ..The slow increase in physical disability in adulthood may well be explained by decreased reserves and compensatory mechanisms together with progression of skeletal deformations due to muscle weakness...
  45. ncbi Diverse synaptic mechanisms generate direction selectivity in the rabbit retina
    W Rowland Taylor
    John Curtin School of Medical Research and Centre for Visual Sciences, Australian National University, Canberra, 2601 ACT, Australia
    J Neurosci 22:7712-20. 2002
    ..The results indicate that, within a single neuron, different strategies are used within distinct dendritic arbors to accomplish the same neural computation...
  46. ncbi Multichannel surface EMG: basic aspects and clinical utility
    Machiel J Zwarts
    Department of Clinical Neurophysiology, Institute of Neurology, University Medical Center Nijmegen, PO Box 9101, NL 6500HB Nijmegen, The Netherlands
    Muscle Nerve 28:1-17. 2003
    ..We conclude that multichannel sEMG adds unique, and sometimes indispensable, spatial information to our knowledge of the motor unit...
  47. ncbi Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals
    Laiche Djouhri
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    Brain Res Brain Res Rev 46:131-45. 2004
    ..It is important that the existence of Abeta nociceptors is recognised, because assumptions that fast conducting, large diameter afferents are always low threshold mechanoreceptors might lead/have led to misinterpretations of data...
  48. ncbi Time-course changes in nerve conduction velocity (NCV) in type 2 diabetes
    Jiro Morimoto
    Saitama Social Insurance Hospital the Department of Internal Medicine, Saitama, Japan
    J Diabetes Complications 26:237-40. 2012
    ..In addition, the natural course of diabetic sensorimotor polyneuropathy (DSPN) was discussed based on the findings...
  49. pmc Progressive axonal dysfunction precedes development of neuropathy in type 2 diabetes
    Jia Ying Sung
    Department of Neurology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
    Diabetes 61:1592-8. 2012
    ....
  50. ncbi Preparation and evaluation of NGF-microsphere conduits for regeneration of defective nerves
    Huayan Sun
    PLA General Hospital, Beijing, China
    Neurol Res 34:491-7. 2012
    ..To fabricate nerve growth factor (NGF) microsphere conduits and evaluate their promotional effects on regeneration of defective nerves...
  51. ncbi The value added by electrodiagnostic testing in the diagnosis of carpal tunnel syndrome
    Brent Graham
    Hand Program, Toronto Western Hospital, 399 Bathurst Street, East Wing 2 425, Toronto, ON M5T 2S8, Canada
    J Bone Joint Surg Am 90:2587-93. 2008
    ....
  52. ncbi Distal degenerative sensory neuropathy in a long-term type 2 diabetes rat model
    Valentine Brussee
    Department of Clinical Neurosciences and the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Diabetes 57:1664-73. 2008
    ..Peripheral neuropathy associated with type 2 diabetes (DPN) is not widely modeled. We describe unique features of DPN in type 2 diabetic Zucker diabetic fatty (ZDF) rats...
  53. pmc Symptoms, signs and nerve conduction velocities in patients with suspected carpal tunnel syndrome
    Georgia Ntani
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
    BMC Musculoskelet Disord 14:242. 2013
    ....
  54. pmc Differences in risk factors for neurophysiologically confirmed carpal tunnel syndrome and illness with similar symptoms but normal median nerve function: a case-control study
    David Coggon
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, UK
    BMC Musculoskelet Disord 14:240. 2013
    ....
  55. ncbi The dynamic clamp comes of age
    Astrid A Prinz
    Volen Center and Department of Biology, Brandeis University, Waltham, MA 02454 9110, USA
    Trends Neurosci 27:218-24. 2004
    ....
  56. pmc Dopamine modulation of Ih improves temporal fidelity of spike propagation in an unmyelinated axon
    Aleksander W Ballo
    The Whitney Laboratory for Marine Bioscience, University of Florida, St Augustine, Florida 32080, USA
    J Neurosci 32:5106-19. 2012
    ..These results indicate that spike conduction can be extremely sensitive to the history of axonal activity and to the presence of neuromodulators, with potentially important consequences for temporal coding...
  57. ncbi Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial
    Nigishi Hotta
    Chubu Rosai Hospital, 1 10 6 Komei, Nagoya 455 8530, Japan
    Diabetes Care 29:1538-44. 2006
    ..We sought to evaluate the long-term efficacy and safety of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy...
  58. pmc Is surgical intervention more effective than non-surgical treatment for carpal tunnel syndrome? A systematic review
    Qiyun Shi
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, L8S 4L8, Canada
    J Orthop Surg Res 6:17. 2011
    ..The purpose of this systematic review was to compare the efficacy of surgical treatment of carpal tunnel syndrome with conservative treatment...
  59. pmc Effects of conduction delays on the existence and stability of one to one phase locking between two pulse-coupled oscillators
    Michael Marmaduke Woodman
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Comput Neurosci 31:401-18. 2011
    ..We successfully tested the predictions of our methods on networks of model neurons. The criteria can easily be extended to include the effect of an input on the cycle after the one in which it is received...
  60. ncbi Prediction of the neurophysiological diagnosis of carpal tunnel syndrome from the demographic and clinical data
    Irenio Gomes
    Neurology Service, Hospital Sao Lucas da PUCRS, Porto Alegre, Brazil
    Clin Neurophysiol 117:964-71. 2006
    ..To use demographic and clinical data to identify the clinical pattern that best predicts the diagnosis of carpal tunnel syndrome (CTS), as defined by neurophysiologic studies...
  61. ncbi Simulation in sensory neurons reveals a key role for delayed Na+ current in subthreshold oscillations and ectopic discharge: implications for neuropathic pain
    Yifat Kovalsky
    Department of Cell and Developmental Biology, Institute of Life Sciences, Center for Research on Pain, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    J Neurophysiol 102:1430-42. 2009
    ..The model reveals the key conductances that underlie afferent ectopia, conductances that are potentially attractive targets in the search for more effective treatments of neuropathic pain...
  62. pmc Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 159:361-72. 2002
    ..The presence of these different tight junction proteins in regions of noncompact myelin may be required to maintain the intricate cytoarchitecture of myelinating Schwann cells...
  63. ncbi Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons
    C Ma
    Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Neurophysiol 95:2098-107. 2006
    ..Inflammatory mediators, by increasing the excitability of DRG somata, may contribute to CCD-induced neuronal hyperexcitability and to hyperalgesia and tactile allodynia...
  64. pmc Inactivation of sodium channels underlies reversible neuropathy during critical illness in rats
    Kevin R Novak
    Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio 45435, USA
    J Clin Invest 119:1150-8. 2009
    ..Acquired sodium channelopathy may be the mechanism underlying acute neuropathy in critically ill patients...
  65. ncbi Effect of extracellular potassium accumulation on muscle fiber conduction velocity: a simulation study
    Emma Fortune
    School of Electrical, Electronic and Mechanical Engineering, University College Dublin, Dublin 4, Ireland
    Ann Biomed Eng 37:2105-17. 2009
    ....
  66. ncbi A reassessment of stress-induced "analgesia" in the rat using an unbiased method
    Pascal Carrive
    School of Medical Sciences, University of New South Wales, NSW 2052, Australia
    Pain 152:676-86. 2011
    ..Less than two-thirds of the increase in tail-flick latency to noxious heat, evoked by conditioned fear, reflects true antinociception. The remaining is due to skin vasoconstriction...
  67. ncbi Nerve repair by end-to-side nerve coaptation: histologic and morphometric evaluation of axonal origin in a rat sciatic nerve model
    Kirsten Haastert
    Hannover Medical School, Institute of Neuroanatomy and Center for Systems Neuroscience, Hannover, Germany
    Neurosurgery 66:567-76; discussion 576-7. 2010
    ..We compared the origin and quality of regenerating myelinated axons after end-to-side neurorrhaphy or end-to-end neurorrhaphy...
  68. ncbi Mutations in GDAP1: autosomal recessive CMT with demyelination and axonopathy
    E Nelis
    Molecular Genetics Department, Flanders Interuniversity Institute of Biotechnology, Belgium
    Neurology 59:1865-72. 2002
    ....
  69. ncbi Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment
    Kazuaki Kanai
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Brain 126:965-73. 2003
    ....
  70. ncbi Carpal tunnel syndrome with normal nerve conduction studies
    John C Witt
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA
    Muscle Nerve 29:515-22. 2004
    ..We concluded that NCS provide independent information in the evaluation of suspected CTS, especially when fewer clinical criteria are present, but that NCS are not helpful in predicting the outcome of nonsurgical management...
  71. ncbi Ultrasonography versus nerve conduction study in patients with carpal tunnel syndrome: substantive or complementary tests?
    Y M El Miedany
    Darent Valley Hospital, Dartford, Kent DA2 8DA, UK
    Rheumatology (Oxford) 43:887-95. 2004
    ....
  72. ncbi The value of the history in the diagnosis of carpal tunnel syndrome
    J D Bland
    EEG Department, Kent and Canterbury Hospital, Kent, UK
    J Hand Surg Br 25:445-50. 2000
    ..A simple regression model for evaluating the history compares favourably with widely used clinical signs in its ability to predict the findings of nerve conduction studies...
  73. ncbi Small fibre impairment predicts neuropathic pain in Guillain-Barré syndrome
    Valéria Martinez
    Université de Versailles St Quentin, AP HP, Hopital Raymond Poincare, Service d Anesthésie Réanimation Chirurgicale, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Pain 151:53-60. 2010
    ..These findings emphasize the importance of nociceptive fibre impairment in NP in GBS at both acute and chronic stages and suggest similarities between the mechanisms of NP in GBS and those of small fibre painful sensory polyneuropathies...
  74. ncbi Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy
    Cory Toth
    University of Calgary, Department of Clinical Neurosciences, Room 155, 3330 Hospital Dr, N W, Calgary, Alberta T2N 4N1, Canada
    Diabetes 57:1002-17. 2008
    ..We studied experimental diabetic neuropathy and its relationship with RAGE expression using streptozotocin-induced diabetic mice including a RAGE(-/-) cohort exposed to long-term diabetes compared with littermates without diabetes...
  75. pmc Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges
    Roberto De Col
    Institute for Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    J Physiol 586:1089-103. 2008
    ..Since the process is primarily dependent upon sodium channel availability, tracking conduction velocity provides a means of accessing relative changes in the excitability of nociceptive neurons...
  76. ncbi Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: multi-parametric assessment and direct evidence
    Laurence Meyer
    Universite de Strasbourg, Bâtiment 3 de la Faculté de Médecine, Strasbourg, France
    Pain 152:170-81. 2011
    ..Together, these results may be interesting for the development of natural or safe neurosteroid-based neuroprotective strategy against anticancer drug-evoked painful neuropathy...
  77. ncbi Neurofascins are required to establish axonal domains for saltatory conduction
    Diane L Sherman
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom
    Neuron 48:737-42. 2005
    ....
  78. ncbi C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
    Karin Ekberg
    Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Diabetes Care 30:71-6. 2007
    ..The present study was undertaken to examine whether C-peptide administration to patients with type 1 diabetes and peripheral neuropathy improves sensory nerve function...
  79. ncbi Activity-dependent excitability changes suggest Na+/K+ pump dysfunction in diabetic neuropathy
    Arun V Krishnan
    Prince of Wales Medical Research Institute, Prince of Wales Clinical School, University of New South Wales, Randwick, Sydney, NSW, Australia
    Brain 131:1209-16. 2008
    ..Alteration in Na(+)/K(+) pump function, coupled with reductions in nodal Na(+) currents, may be sufficient to trigger conduction failure in DN patients and are likely to contribute to the clinical symptoms of weakness and fatigue...
  80. ncbi Relationship between the self-administered Boston questionnaire and electrophysiological findings in follow-up of surgically-treated carpal tunnel syndrome
    M Mondelli
    Unit of Neurosurgery, Azienda Ospedialiera Senese and Department of Neurology, Catholic University, Rome, Italy
    J Hand Surg Br 25:128-34. 2000
    ....
  81. ncbi Exploring a critical parameter of timing in the mouse cerebellar microcircuitry: the parallel fiber diameter
    F Sultan
    Sektion fur Visuelle Sensomotorik, Neurologische Universitätsklinik Tübingen, Germany
    Neurosci Lett 280:41-4. 2000
    ....
  82. ncbi Electrical synapses and synchrony: the role of intrinsic currents
    Benjamin Pfeuty
    Laboratoire de Neurophysique et Physiologie du Système Moteur, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8119, Universite Rene Descartes, 75270 Paris Cedex 06, France
    J Neurosci 23:6280-94. 2003
    ..It also suggests different synchronization properties for LTS and FS cells. Finally, we propose to further test our predictions in experiments using dynamic clamp techniques...
  83. ncbi Diagnostic utility of ultrasonography versus nerve conduction studies in mild carpal tunnel syndrome
    Mauro Mondelli
    EMG Service ASL 7, Siena, Italy
    Arthritis Rheum 59:357-66. 2008
    ..To prospectively compare high-resolution ultrasonography (US) and nerve conduction velocity (NCV) in clinically diagnosed mild carpal tunnel syndrome (CTS)...
  84. ncbi Axonal neuregulin-1 regulates myelin sheath thickness
    Galin V Michailov
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Science 304:700-3. 2004
    ..We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size...
  85. ncbi Osteoarthritis: symptoms, signs and source of pain
    W F Kean
    Hamilton Health Sciences, McMaster University, Ontario, Canada
    Inflammopharmacology 12:3-31. 2004
    ..This lack of correlation of clinical evaluation and imaging makes attempts at treatment difficult and compromises attempts to design studies and to evaluate the outcome of osteoarthritis in clinical trials...
  86. ncbi Conduction velocity of nerve and muscle fiber action potentials after a space mission or a bed rest
    Dieter G Ruegg
    Institute of Physiology, University of Fribourg, Rue du Musee 5, CH 1700, Fribourg, Switzerland
    Clin Neurophysiol 114:86-93. 2003
    ..The purpose of the present investigation was to study the readaptation of a human muscle after a prolonged stay in microgravity and after a bed rest of several months...
  87. pmc Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy
    James F McGuire
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA
    Diabetes 58:2677-86. 2009
    ..Evaluate if Erb B2 activation and the loss of caveolin-1 (Cav1) contribute to the pathophysiological progression of diabetic peripheral neuropathy (DPN)...
  88. ncbi Carpal tunnel syndrome: diagnostic usefulness of sonography
    Shiu Man Wong
    Department of Medicine, Prince of Wales Hospital, Shatin, Hong Kong
    Radiology 232:93-9. 2004
    ..To prospectively evaluate accuracy of sonography for diagnosis of carpal tunnel syndrome (CTS) in patients clinically suspected of having the disease in one or both hands...
  89. ncbi The acute effects of glycemic control on axonal excitability in human diabetic nerves
    Satoshi Kuwabara
    Department of Neurology, Chiba University School of Medicine
    Intern Med 41:360-5. 2002
    ..It is known that voluntary contraction or compression ischemia alters nerve Na+/K+ pump activity, and axonal excitability changes due to the pump activity can be estimated by threshold tracking...
  90. ncbi Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy
    M J Stevens
    Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor 48109 0678, USA
    Diabetes 49:1006-15. 2000
    ..They reveal complex interrelationships among nerve perfusion, energy metabolism, osmolyte content, conduction velocity, and oxidative stress that may reflect the heterogeneous and compartmentalized composition of peripheral nerve...
  91. pmc Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve
    Lawrence J Coppey
    Veterans Affairs Medical Center, Department of Internal Medicine, University of Iowa, Iowa City 52246, USA
    Int J Exp Diabetes Res 3:21-36. 2002
    ..These studies suggest that sorbinil treatment may be more effective in preventing neural dysfunction in diabetes than either aminoguanidine or myo-inositol...
  92. ncbi Severity of Carpal tunnel syndrome assessed with high frequency ultrasonography
    Yeşim Sücüllü Karadağ
    1st Neurology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
    Rheumatol Int 30:761-5. 2010
    ..In addition to CTS diagnosis, sonographic measurement of CSA could also give additional information about severity of median nerve involvement. Using of US may cost-effectively reduce the number of NCS in patients with suspected CTS...
  93. ncbi Effect of aging on sensory nerve conduction study parameters
    Henry C Tong
    Department of Physical Medicine and Rehabilitation, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Muscle Nerve 29:716-20. 2004
    ..The rate of change seen with some of the median nerve parameters was significantly greater than that with the ulnar nerve...
  94. pmc Action potentials contribute to neuronal signaling in C. elegans
    Jerry E Mellem
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    Nat Neurosci 11:865-7. 2008
    ..These neurons resembled Schmitt triggers, as their potential state appears to be bistable. Transitions between up and down states could be triggered by application of the neurotransmitter glutamate or brief current pulses...
  95. ncbi Multifocal motor neuropathy: pathologic alterations at the site of conduction block
    Bruce V Taylor
    Department of Neurology, Royal Hobart Hospital, Hobart Tasmania, Australia
    J Neuropathol Exp Neurol 63:129-37. 2004
    ....
  96. ncbi Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome
    K Viala
    Fédération de Neurophysiologie Clinique, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Brain 127:2010-7. 2004
    ..Overall, whatever the clinical course, LSS responded to immune-mediated treatment in a manner similar to CIDP...
  97. ncbi Neuropathy progression in Charcot-Marie-Tooth disease type 1A
    M E Shy
    Wayne State University, Department of Neurology, Center for Molecular Medicine and Genetics, 421 Ea Canfield, Detroit, MI 48201, USA
    Neurology 70:378-83. 2008
    ..To determine the rate of disease progression in Charcot-Marie-Tooth disease type 1A (CMT1A)...
  98. ncbi Space-clamp problems when voltage clamping neurons expressing voltage-gated conductances
    Dan Bar-Yehuda
    Mina and Everard Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Neurophysiol 99:1127-36. 2008
    ..Our results demonstrate that voltage-gated K(+) and Ca(2+) currents recorded from branching neurons are almost always severely distorted...
  99. ncbi A clinical, electrophysiological, and pathological study of neuropathy in rheumatoid arthritis
    Vikas Agarwal
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India
    Clin Rheumatol 27:841-4. 2008
    ..Pathologically, neuropathy secondary to amyloid infiltration was second only to vasculitic neuropathy. Absence of deep tendon jerks and presence of vasculitis were more commonly observed in patients with neuropathy...
  100. ncbi A new method for the estimation of motor nerve conduction block
    Luca Mesin
    LISiN, Dipartimento di Elettronica, Politecnico di Torino, Corso Duca degli Abruzzi 24, Turin 10129, Italy
    Clin Neurophysiol 118:730-40. 2007
    ....
  101. ncbi Impaired neural conduction in crossed visual pathways in patients with ocular hypertension
    V Parisi
    Ophthalmology Department, University of Roma Tor Vergata, Roma Italy
    Eur J Ophthalmol 14:486-94. 2004
    To evaluate the neural conduction along crossed and uncrossed visual pathways in patients with ocular hypertension (OHT).

Research Grants69

  1. Surgical Management of Facial Nerve Injury
    Theresa Hadlock; Fiscal Year: 2007
    ..The academic environment is one of complete dedication to advancing both biomedical science and patient care through careful study and diligent investigation, and of support for the mentored investigator. [unreadable] [unreadable]..
  2. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2010
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  3. Microgenomic Studies of ALS
    John Ravits; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  4. PROSAPOSIN AND PROSAPTIDES IN DIABETIC NEUROPATHY
    NIGEL CALCUTT; Fiscal Year: 2002
    ..The goal is to establish prosaptides as novel therapeutic agents for treating diabetic neuropathy and to provide mechanistic explanations for why hyperglycemia causes nerve disorders. ..
  5. Carotid Body Chemoreception: Mechanism & Development
    DAVID DONNELLY; Fiscal Year: 2006
    ..If supported, the model should lead to a pharmacologic targeting of these processes for the improved treatment of apnea and/or dyspnea. ..
  6. Left-Right Asymmetry of the Developing Diecephalon
    Marnie E Halpern; Fiscal Year: 2013
    ..system, the zebrafish, will increase our knowledge of how left-right differences arise in the developing brain by characterizing asymmetry in a highly conserved yet poorly understood forebrain to midbrain neural conduction pathway.
  7. Spinal Cord-to-Computer Interface
    Mesut Sahin; Fiscal Year: 2013
    ..from trauma or disease, skeletal muscles distal to the point of damage become paralyzed due to disrupted neural conduction. In high-level spinal cord injury/damage, there is a great need for a method that can substitute for the ..
  8. The Neurobiology of Auditory Perception in Autism
    Nicole Gage; Fiscal Year: 2006
    ..Importantly, MEG has been demonstrated to be well tolerated by children with AD. Recent evidence for slowed neural conduction times at the auditory brainstem in autistic children combines with our preliminary MEG data showing general ..
  9. Network vasomotor response to tissue adenosine
    Richard Rivers; Fiscal Year: 2007
    ..This has raised a couple of fundamental questions: 1) can this mechanism cause maximal vasodilation? 2) is neural conduction a component of the network response? 3) where are the adenosine receptors that initiate the response? 4) has ..
  10. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  11. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  12. DIABETIC NEUROPATHY STUDY
    PETER DYCK; Fiscal Year: 2008
    ..abstract_text> ..
  13. Epidermal Innervation as an Outcome Measure
    David Herrmann; Fiscal Year: 2006
    ..Dr. Herrmann will also examine a method to simplify the analysis of skin biopsy specimens, for easier application in large clinical trials. ..
  14. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..Frequent consultation with a neurosurgeon, who is a member of the research team, will provide necessary input to direct the study and experiments towards clinically relevant solutions for transection nerve injuries. ..
  15. In-Vivo Confocal Imaging of Meissner's Corpuscles as a Measure of HIV Neuropathy
    David Herrmann; Fiscal Year: 2008
    ..In-vivo RCM of MCs may prove to have wide application for early identification of sensory peripheral neuropathies, and to assess effectiveness of therapy. [unreadable] [unreadable] [unreadable]..
  16. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  17. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  18. Oxidative Stress and Nerve Pathology in Diabetes
    Andrew Mizisin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
  20. Near Infra Red Energy To Treat Diabetic Neuropathy
    NIGEL CALCUTT; Fiscal Year: 2006
    ..abstract_text> ..
  21. MECHANISM OF PAIN IN PATIENTS WITH FIBROMYALGIA SYNDROME
    Roland Staud; Fiscal Year: 2008
    ..In addition, our findings may contribute to the understanding of pain mechanisms related to other chronic pain disorders. ..
  22. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
    ..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
  23. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  24. TRANSDUCTION OF CHRONIC NERVE INJURY BY SCHWANN CELLS
    Ranjan Gupta; Fiscal Year: 2004
    ..Successful completion of these studies will provide a greater understanding of the pathogenesis of CNI so that more effective treatment modalities may be developed. ..
  25. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
  26. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
  27. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  28. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
    ....
  29. Reducing Risk Factors in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ....
  30. RAPID MR VS XRAY: RANDOMIZED OUTCOME TRIAL FOR BACK PAIN
    JEFFREY JARVIK; Fiscal Year: 2001
    ..We have a window of opportunity before the rapid MRI becomes widely disseminated and a randomized trial is made impossible by the expectations of both patients and physicians. ..
  31. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  32. Molecular Mechanisms of Neurodegeneration
    Alexander Gow; Fiscal Year: 2010
    ..Our paradigm will enable us to characterize the temporal sequence of events that generate the pathophysiology of neurodegeneration associated with protein trafficking defects in oligodendrocytes. ..
  33. Acute Rotator Cuff Tendon Changes Associated with Wheelchair Propulsion
    Michael Boninger; Fiscal Year: 2008
    ..This type of information is critical to appropriate selection of interventions in subsequent controlled trials. [unreadable] [unreadable]..
  34. Upgrade of the Yale 3T Trio Imaging System
    R Constable; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Paraspinal Denervation in Low Back Pain
    Andrew J Haig; Fiscal Year: 2010
    ..The results will help doctors avoid unnecessary surgery and help scientists to understand more about how spinal stenosis disables so many older people. ..
  36. Designing musculoskeletal disorder interventions for imaging technologists
    Carolyn M Sommerich; Fiscal Year: 2010
    ....
  37. Upper Limb Musculoskeletal Disorders: Quantifying Risk
    Arun Garg; Fiscal Year: 2008
    ..This project is expected to result in DUE and shoulder job analysis models that have robust predictive capabilities for a broad range of jobs. [unreadable] [unreadable] [unreadable]..
  38. HEARING DEFICIT DUE TO AUDITORY NEUROPATHY
    Arnold Starr; Fiscal Year: 2009
    ..The results of our studies could have major impact on the diagnosis, classification, understanding, and treatment of auditory neuropathy. ..
  39. Cellular Mechanisms for Oligodendrocyte Myelination
    Bruce D Trapp; Fiscal Year: 2010
    ..Collectively, these studies should identify therapeutic targets that enhance remyelination and reduce the progression of neurological disability in MS patients. ..
  40. Corticothalamic Neurons in Sensorimotor Cortex
    Daniel J Simons; Fiscal Year: 2010
    ..The research plan should lead to new insights into how - and perhaps, why - the cerebral cortex regulates its own activity during information processing states. ..
  41. Pharmacotoxicology of Trichloroethylene Metabolites
    Peter W Stacpoole; Fiscal Year: 2010
    ....
  42. Obesity Effects on Pharyngeal Airway Mechanics by MRI
    Michael J Brennick; Fiscal Year: 2010
    ..The proposed studies will provide new information on how obesity affects pharyngeal mechanics and increase our understanding of why obese patients are predisposed to pharyngeal airway collapse during sleep. ..
  43. IONIC CHANNELS IN MAMMALIAN MYELINATED NERVES
    SHING CHIU; Fiscal Year: 2004
    ..Relatedly, the role of Kvbeta subunits, which colocalize with Kv1.1 and are thought to promote efficient surface expression, will be examined in Kvbeta mutant mice (also generated in our laboratory). ..
  44. Novel anesthetic mechanisms that desensitize nociceptors
    Lieju Liu; Fiscal Year: 2006
    ..This information will lead to novel anesthetic mechanisms that involve the reversible desensitization of nociceptors. ..
  45. Neuronal variability and invariants
    Adam Taylor; Fiscal Year: 2006
    ..This work will provide important insights about how nervous systems regulate themselves to maintain proper function. ..
  46. FUNCTIONAL HETEREOGENEITY OF THE HIPPOCAMPAL FORMATION
    R Constable; Fiscal Year: 2003
    ..This work will have significant impact in both the neuroscience and medical communities. ..
  47. Pharyngeal mechanics by tagged MRI in a Zucker rat model
    MICHAEL BRENNICK; Fiscal Year: 2004
    ..abstract_text> ..
  48. EXPERIMENTAL INDUCTION OF CARPAL TUNNEL SYNDROME
    Edward Diao; Fiscal Year: 2004
    ..provides the foundation for future study on the efficacy of pharmacologic and other intervention modalities in human clinical trials. ..
  49. REPAIRING SENSORY PATHWAYS AFTER SPINAL CORD INJURY
    STEPHEN ONIFER; Fiscal Year: 2004
    ....
  50. Neurophysiological mechanisms underlying spasms in SCI
    Maria Knikou; Fiscal Year: 2004
    ..A future study can be concentrated on the potential reflex pathways underlying spasms and their relation to hip extension (end of stance phase) during assisted locomotion in incomplete SCI patients. ..
  51. MUSCULOSKELETAL PLASTICITY AFTER SPINAL CORD INJURY
    RICHARD SHIELDS; Fiscal Year: 2003
    ..The benefits of this newly developed adaptive feedback controlled exercise may provide a standard that individuals with paralysis may use in an effort to maintain their musculoskeletal properties following paralysis. ..
  52. NAD & CD38 Form a Communication System in the Retina
    Robert Miller; Fiscal Year: 2006
    ..If this hypothesis can be experimentally established, it will form the basis of an entirely new method by which neurons and glia support each other to stabilize retinal function. ..
  53. Synapase Modification /Memory Retention /Life Span Model
    Peter Patrylo; Fiscal Year: 2002
    ..abstract_text> ..
  54. NEUROPHYSIOLOGICAL CONSEQUENCES OF LUMBAR FACET MOVEMENT
    Joel Pickar; Fiscal Year: 2001
    ....
  55. EPILEPTOGENESIS IN THE AGED CNS
    Peter Patrylo; Fiscal Year: 2002
    ..Thus, by examining synaptic reorganization within the aged CNS they may also provide insight into the basic mechanisms of epilepsy and learning and memory within the overall population. ..
  56. Electrophysiologic Measurements in Diabetic Neuropathy
    Joseph Arezzo; Fiscal Year: 2007
    ..If successful, these studies will result in new methods, more sensitive animal models and a better understanding of the nature, magnitude, time course, and response to therapy of functional deficits in DAN. ..
  57. SYNAPTIC PLASTICITY OF HYPOTHALAMIC NEURONS--ESTROGENS
    OLINE RONNEKLEIV; Fiscal Year: 2002
    ....
  58. Dementia Caregiver Treatment for Nursing Home Transition
    Jennifer Davis; Fiscal Year: 2006
    ..This low-cost intervention may be useful as part of routine care for dementia caregivers transitioning their family member to long-term care facilities. [unreadable] [unreadable]..
  59. Biodegradable Polymer Implants for Spinal Cord Repair
    Anthony Windebank; Fiscal Year: 2006
    ..Imaging with Micro-CT and MR microscopy will be combined with histological and functional assessments to measure success in promoting regeneration. ..
  60. A Novel Waveform for Electrical Nerve Conduction Block
    Kevin Kilgore; Fiscal Year: 2002
    ..The initial intended human application will be to alleviate pain in individuals with neuromas secondary to limb amputation. ..
  61. PARASPINAL MUSCLE DENERVATION AND SYMPTOMS IN LUMBAR SS
    Andrew Haig; Fiscal Year: 2005
    ..Subjects will repeat the test battery (MRI, EMG, and clinical evaluation) approximately 18 months later. Appropriate statistics will test each of the four hypotheses. ..
  62. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2006
    ..As part of this aim, a prototype device for easy use will be developed and tested in the clinical setting. ..
  63. MOLECULAR MECHANISMS OF SCHWANN CELL MYELINATION
    Bruce Trapp; Fiscal Year: 2008
    ....
  64. Assessment of Penile Autonomic Innervation
    Claire Yang; Fiscal Year: 2007
    ..The ability to detect cavernous neuropathy is relevant to the evaluation of erectile dysfunction, as well as the development of disease-specific treatments for neurogenic erectile dysfunction. [unreadable] [unreadable]..
  65. MOLECULAR ANALYSIS OF MYOTONIC DYSTROPHY
    SATYAKAM BHAGWATI; Fiscal Year: 2002
    ..This approach is designed to explore the function of these CTG/CUG repeat binding proteins and their possible role in the pathogenesis of DM. ..
  66. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..