intracranial pressure

Summary

Summary: Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.

Top Publications

  1. ncbi MR-Intracranial pressure (ICP): a method to measure intracranial elastance and pressure noninvasively by means of MR imaging: baboon and human study
    N J Alperin
    Departments of Radiology, University of Illinois at Chicago, 1740 W Taylor, Chicago, IL 60612, USA
    Radiology 217:877-85. 2000
  2. ncbi The Camino intracranial pressure device in clinical practice. Assessment in a 1000 cases
    M Gelabert-Gonzalez
    Neurosurgical Service, Department of Surgery, Hospital of Santiago de Compostela, University of Santiago de Compostela, Spain
    Acta Neurochir (Wien) 148:435-41. 2006
  3. doi Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses
    Fatemeh Dehghan
    Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
    Arch Med Res 44:251-8. 2013
  4. pmc Monitoring and interpretation of intracranial pressure
    M Czosnyka
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    J Neurol Neurosurg Psychiatry 75:813-21. 2004
  5. ncbi Comparison of simultaneous continuous intracranial pressure (ICP) signals from a Codman and a Camino ICP sensor
    Per Kristian Eide
    Department of Neurosurgery, The National Hospital Rikshospitalet, 0027 Oslo, Norway
    Med Eng Phys 28:542-9. 2006
  6. ncbi Ultrasonography of the optic nerve sheath may be useful for detecting raised intracranial pressure after severe brain injury
    Thomas Geeraerts
    Department of Anesthesiology and Critical Care Medicine, Hospital of Bicetre, Assistance Publique Hopitaux de Paris AP HP, Faculty of Medicine, University of Paris Sud, Le Kremlin Bicetre, 94275, Paris, France
    Intensive Care Med 33:1704-11. 2007
  7. doi Standardized induction of subarachnoid hemorrhage in mice by intracranial pressure monitoring
    Sergej Feiler
    Institute for Surgical Research and Department of Neurosurgery, University of Munich Medical Center Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    J Neurosci Methods 190:164-70. 2010
  8. doi Retinal vein pulsation is in phase with intracranial pressure and not intraocular pressure
    William H Morgan
    Lions Eye Institute, Centre for Ophthalmology and Visual Science, Nedlands, WA, Australia
    Invest Ophthalmol Vis Sci 53:4676-81. 2012
  9. doi Factors influencing intracranial pressure monitoring guideline compliance and outcome after severe traumatic brain injury
    Heleen A R Biersteker
    Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Crit Care Med 40:1914-22. 2012
  10. ncbi Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 29:2461-6. 1998

Detail Information

Publications422 found, 100 shown here

  1. ncbi MR-Intracranial pressure (ICP): a method to measure intracranial elastance and pressure noninvasively by means of MR imaging: baboon and human study
    N J Alperin
    Departments of Radiology, University of Illinois at Chicago, 1740 W Taylor, Chicago, IL 60612, USA
    Radiology 217:877-85. 2000
    To develop a noninvasive method for intracranial elastance and intracranial pressure (ICP) measurement.
  2. ncbi The Camino intracranial pressure device in clinical practice. Assessment in a 1000 cases
    M Gelabert-Gonzalez
    Neurosurgical Service, Department of Surgery, Hospital of Santiago de Compostela, University of Santiago de Compostela, Spain
    Acta Neurochir (Wien) 148:435-41. 2006
    b>Intracranial pressure (ICP) monitoring has become standard in the management of neurocritical patients. A variety of monitoring techniques and devices are available, each offering advantages and disadvantages...
  3. doi Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses
    Fatemeh Dehghan
    Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
    Arch Med Res 44:251-8. 2013
    Traumatic brain injury (TBI) is one of the main causes of brain edema and increased intracranial pressure (ICP). In the clinic it is essential to limit the development of ICP after TBI...
  4. pmc Monitoring and interpretation of intracranial pressure
    M Czosnyka
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    J Neurol Neurosurg Psychiatry 75:813-21. 2004
    b>Intracranial pressure (ICP) is derived from cerebral blood and cerebrospinal fluid (CSF) circulatory dynamics and can be affected in the course of many diseases of the central nervous system...
  5. ncbi Comparison of simultaneous continuous intracranial pressure (ICP) signals from a Codman and a Camino ICP sensor
    Per Kristian Eide
    Department of Neurosurgery, The National Hospital Rikshospitalet, 0027 Oslo, Norway
    Med Eng Phys 28:542-9. 2006
    Simultaneous continuous intracranial pressure (ICP) signals from two different sensors were compared. Continuous ICP monitoring from two ICP sensors (i.e...
  6. ncbi Ultrasonography of the optic nerve sheath may be useful for detecting raised intracranial pressure after severe brain injury
    Thomas Geeraerts
    Department of Anesthesiology and Critical Care Medicine, Hospital of Bicetre, Assistance Publique Hopitaux de Paris AP HP, Faculty of Medicine, University of Paris Sud, Le Kremlin Bicetre, 94275, Paris, France
    Intensive Care Med 33:1704-11. 2007
    To assess at admission to the ICU the relationship between optic nerve sheath diameter (ONSD) and intracranial pressure (ICP) and to investigate whether increased ONSD at patient admission is associated with raised ICP in the first 48[..
  7. doi Standardized induction of subarachnoid hemorrhage in mice by intracranial pressure monitoring
    Sergej Feiler
    Institute for Surgical Research and Department of Neurosurgery, University of Munich Medical Center Grosshadern, Marchioninistr 15, 81377 Munich, Germany
    J Neurosci Methods 190:164-70. 2010
    ....
  8. doi Retinal vein pulsation is in phase with intracranial pressure and not intraocular pressure
    William H Morgan
    Lions Eye Institute, Centre for Ophthalmology and Visual Science, Nedlands, WA, Australia
    Invest Ophthalmol Vis Sci 53:4676-81. 2012
    As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses.
  9. doi Factors influencing intracranial pressure monitoring guideline compliance and outcome after severe traumatic brain injury
    Heleen A R Biersteker
    Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Crit Care Med 40:1914-22. 2012
    To determine adherence to Brain Trauma Foundation guidelines for intracranial pressure monitoring after severe traumatic brain injury, to investigate if characteristics of patients treated according to guidelines (ICP+) differ from those ..
  10. ncbi Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 29:2461-6. 1998
    ..Clinical studies on moderate hypothermia in the treatment of acute ischemic stroke patients are still lacking...
  11. doi Cerebrospinal fluid pressure in ocular hypertension
    Ruojin Ren
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, China
    Acta Ophthalmol 89:e142-8. 2011
    ..To assess the lumbar cerebrospinal fluid pressure (CSF-P) in ocular hypertensive subjects with elevated intraocular pressure (IOP) but without development of glaucomatous optic nerve damage...
  12. pmc Detrended fluctuation analysis of intracranial pressure predicts outcome following traumatic brain injury
    Robert L Burr
    Department of Biobehavioral Nursing and Health Systems, University ofWashington, Seattle, Washington 98195 7266, USA
    IEEE Trans Biomed Eng 55:2509-18. 2008
    ..The purpose of this study is to explore applicability of DFA methods to intracranial pressure (ICP) signals recorded in patients with traumatic brain injury (TBI)...
  13. doi Monitoring intracranial pressure in traumatic brain injury
    Martin Smith
    National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Trust, London, UK
    Anesth Analg 106:240-8. 2008
    Increased intracranial pressure (ICP) is an important cause of secondary brain injury, and ICP monitoring has become an established component of brain monitoring after traumatic brain injury...
  14. doi Intracranial pressure increases during exposure to a shock wave
    Alessandra Dal Cengio Leonardi
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan 48201, USA
    J Neurotrauma 28:85-94. 2011
    ..In addition, we optimized in vivo methods to ensure accurate measurement of intracranial pressure (ICP)...
  15. pmc Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study
    John P Berdahl
    Duke University Eye Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 49:5412-8. 2008
    To compare intracranial pressure (ICP) in subjects with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG; subset of POAG), and ocular hypertension (OHT) with that in subjects with no glaucoma.
  16. doi Biomechanical assessment of brain dynamic responses due to blast pressure waves
    M S Chafi
    Department of Mechanical Engineering and Applied Mechanics, North Dakota State University, Fargo, ND 58105 5285, USA
    Ann Biomed Eng 38:490-504. 2010
    ..model is a 3-D geometrically realistic configuration that has been previously validated against the brain intracranial pressure (ICP), as well as shear and principal strains under different impact loadings of cadaveric experimental ..
  17. ncbi Consensus meeting on microdialysis in neurointensive care
    Bo Michael Bellander
    Section of Neurosurgery, Department of Clinical Neuroscience, Karolinska Institutet and Hospital, Stockholm, Sweden
    Intensive Care Med 30:2166-9. 2004
    ..Microdialysis is used in many European neurointensive care units to monitor brain chemistry in patients suffering subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI)...
  18. ncbi Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial
    Andrew I R Maas
    Department of Neurosurgery, Erasmus MC Rotterdam, Rotterdam, Netherlands
    Lancet Neurol 5:38-45. 2006
    ..Traumatic brain injury is a major cause of death and disability. We sought to assess the safety and efficacy of dexanabinol, a synthetic cannabinoid analogue devoid of psychotropic activity, in severe traumatic brain injury...
  19. ncbi A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild Hypothermia Study Group in Japan
    T Shiozaki
    Department of Traumatology, Osaka University Medical School, Kinki University School of Medicine, Japan
    J Neurosurg 94:50-4. 2001
    ..A prospective randomized controlled trial was conducted to determine whether mild hypothermia is essential in the treatment of severely head injured patients with low intracranial pressure (ICP).
  20. ncbi Relationship between intracranial pressure and other clinical variables in patients with aneurysmal subarachnoid hemorrhage
    Gregory G Heuer
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg 101:408-16. 2004
    Increased intracranial pressure (ICP) is well known to affect adversely patients with head injury...
  21. doi Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients
    Per Kristian Eide
    Division of Clinical Neuroscience, Department of Neurosurgery, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Neurosurgery 66:80-91. 2010
    To review our experience of managing idiopathic normal pressure hydrocephalus (iNPH) during the 6-year period from 2002 to 2007, when intracranial pressure (ICP) monitoring was part of the diagnostic workup.
  22. doi Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressure
    Georgene Hergenroeder
    Vivian L Smith Center for Neurologic Research, University of Texas Medical School, Houston, TX, USA
    J Neurotrauma 25:79-93. 2008
    ..Analysis of serum RBP4 levels at 24-36 h post-injury indicates it may predict subsequent increases in intracranial pressure (ICP) with a sensitivity of 86% and specificity of 88% at 11...
  23. pmc The baseline pressure of intracranial pressure (ICP) sensors can be altered by electrostatic discharges
    Per K Eide
    Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Biomed Eng Online 10:75. 2011
    The monitoring of intracranial pressure (ICP) has a crucial role in the surveillance of patients with brain injury...
  24. doi A randomized and blinded single-center trial comparing the effect of intracranial pressure and intracranial pressure wave amplitude-guided intensive care management on early clinical state and 12-month outcome in patients with aneurysmal subarachnoid hemo
    Per Kristian Eide
    Department of Neurosurgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Neurosurgery 69:1105-15. 2011
    ..with aneurysmal subarachnoid hemorrhage (SAH), preliminary results indicate that the amplitude of the single intracranial pressure (ICP) wave is a better predictor of the early clinical state and 6-month outcome than the mean ICP.
  25. doi A survey of ventriculostomy and intracranial pressure monitor placement practices
    Brent R O'Neill
    Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Surg Neurol 70:268-73; discussion 273. 2008
    ..Although ventriculostomy and ICP monitor placement are among the most commonly performed neurosurgical procedures, few studies have examined the current practice patterns of these procedures...
  26. doi Measuring elevated intracranial pressure through noninvasive methods: a review of the literature
    Helena Kristiansson
    Department of Neurosurgery, University Hospital of Lund, Lund, Sweden
    J Neurosurg Anesthesiol 25:372-85. 2013
    Elevated intracranial pressure (ICP) is an important cause of secondary brain injury, and a measurement of ICP is often of crucial value in neurosurgical and neurological patients...
  27. doi Diagnosis and grading of papilledema in patients with raised intracranial pressure using optical coherence tomography vs clinical expert assessment using a clinical staging scale
    Colin J Scott
    Department of Ophthalmology and Visual Sciences, Carver School of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Arch Ophthalmol 128:705-11. 2010
    ..To compare and contrast 2 methods of quantitating papilledema, namely, optical coherence tomography (OCT) and Modified Frisén Scale (MFS)...
  28. pmc Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis
    Emma J Robertson
    Department of Infection and Immunity, St George s University of London, London, United Kingdom
    J Infect Dis 209:74-82. 2014
    ..The organism and/or shed capsule is postulated to raise intracranial pressure (ICP) in cryptococcal meningitis (CM) by mechanical obstruction of cerebrospinal fluid (CSF) outflow...
  29. pmc Dorsomedial/Perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient
    Brian C Samuels
    Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Invest Ophthalmol Vis Sci 53:7328-35. 2012
    ..Further, decreases in intracranial pressure (ICP), with postulated increases in the translaminar pressure gradient across the lamina cribrosa, has ..
  30. ncbi Prone position in subarachnoid hemorrhage patients with acute respiratory distress syndrome: effects on cerebral tissue oxygenation and intracranial pressure
    Andrea Reinprecht
    Department of Neurosurgery, University of Vienna Medical School, Vienna, Austria
    Crit Care Med 31:1831-8. 2003
    ..To analyze the effect of prone position on cerebral perfusion pressure and brain tissue oxygen partial pressure in subarachnoid hemorrhage patients with acute respiratory distress syndrome (ARDS)...
  31. doi Index of cerebrospinal compensatory reserve in hydrocephalus
    Dong Joo Kim
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, England
    Neurosurgery 64:494-501; discussion 501-2. 2009
    ..It is numerically computed as a linear correlation coefficient between the mean intracranial pressure and the pulse amplitude of the pressure waveform...
  32. pmc Simultaneous monitoring of static and dynamic intracranial pressure parameters from two separate sensors in patients with cerebral bleeds: comparison of findings
    Per Kristian Eide
    Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Biomed Eng Online 11:66. 2012
    We recently reported that in an experimental setting the zero pressure level of solid intracranial pressure (ICP) sensors can be altered by electrostatics discharges...
  33. doi A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury
    Sarah B Rockswold
    Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota, USA
    J Neurosurg 118:1317-28. 2013
    ..The brain appears better able to use baseline O2 levels following HBO2 treatments. In this study, the authors evaluate the combination of HBO2 and normobaric hyperoxia (NBH) as a single treatment...
  34. doi Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis
    Julie Dubourg
    INSERM, CIC201, Service de Pharmacologie Clinique, EPICIME, Groupement Hospitalier Est, Hospices Civils de Lyon, Universite Claude Bernard Lyon 1, 59 Boulevard Pinel, 69000, Lyon, France
    Intensive Care Med 37:1059-68. 2011
    ..To evaluate the diagnostic accuracy of ultrasonography of optic nerve sheath diameter (ONSD) for assessment of intracranial hypertension...
  35. doi Static and pulsatile intracranial pressure in idiopathic intracranial hypertension
    Per Kristian Eide
    Department of Neurosurgery, Oslo University Hospital Rikshospitalet, Oslo, Norway University of Oslo, Oslo, Norway
    Clin Neurol Neurosurg 113:123-8. 2011
    The aim of this observational study was to characterize the static and pulsatile intracranial pressure (ICP) in conservatively (medically) treated idiopathic intracranial hypertension (IIH) patients in need of shunt surgery, and also in ..
  36. ncbi Effects of induced hypertension on intracranial pressure and flow velocities of the middle cerebral arteries in patients with large hemispheric stroke
    Stefan Schwarz
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:998-1004. 2002
    ..Our aim was to prospectively evaluate the effects of induced arterial hypertension in patients with large ischemic stroke...
  37. doi Extracellular brain ammonia levels in association with arterial ammonia, intracranial pressure and the use of albumin dialysis devices in pigs with acute liver failure
    Kerstin Zwirner
    Department of General, Visceral and Transplant Surgery, Tuebingen University Hospital, Tuebingen, Germany
    Metab Brain Dis 25:407-12. 2010
    ..of hepatic encephalopathy (HE) but does not always correlate with the severity of mental deterioration and intracranial pressure (ICP)...
  38. ncbi Hypertonic saline (7.2%) in 6% hydroxyethyl starch reduces intracranial pressure and improves hemodynamics in a placebo-controlled study involving stable patients with subarachnoid hemorrhage
    Gunnar Bentsen
    Department of Anesthesiology and Intensive Care, Rikshospitalet Radiumhospitalet Medical Center, Faculty of Medicine, University of Oslo, Oslo, Norway
    Crit Care Med 34:2912-7. 2006
    ..the effects of a bolus infusion of hypertonic saline hydroxyethyl starch with the effects of normal saline (placebo) on intracranial pressure (ICP) and cerebral perfusion pressure in patients with spontaneous subarachnoid hemorrhage.
  39. doi The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure
    Peter Nissen Bjerring
    Department of Hepatology, Rigshospitalet, Copenhagen, Denmark
    J Hepatol 57:774-9. 2012
    ..This study aimed at assessing the effect of fractionated plasma separation and adsorption (FPSA), an extracorporeal liver support system, on cerebral amino acids and lactate to pyruvate ratio...
  40. doi Decompressive craniectomy: a meta-analysis of influences on intracranial pressure and cerebral perfusion pressure in the treatment of traumatic brain injury
    Edson Bor-Seng-Shu
    Division of Neurological Surgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Brazil
    J Neurosurg 117:589-96. 2012
    ..The purpose of this review was to evaluate the contribution of decompressive craniectomy in reducing intracranial pressure (ICP) and increasing cerebral perfusion pressure (CPP) in these patients.
  41. ncbi Continuous ventricular cerebrospinal fluid drainage with intracranial pressure monitoring for management of posttraumatic diffuse brain swelling
    Almir Ferreira de Andrade
    Department of Neurology and Neurosurgery, Clinical s Hospital, University of Sao Paulo Medical School, SP, Brazil
    Arq Neuropsiquiatr 69:79-84. 2011
    ..The aim of the present study was describe outcomes in a series of 57 patients with diffuse brain swelling underwent to intracranial pressure (ICP) monitoring.
  42. doi Electrostatic discharges and their effect on the validity of registered values in intracranial pressure monitors
    Morten Andresen
    Clinic of Neurosurgery, Copenhagen University Hospital, Copenhagen and
    J Neurosurg 119:1119-24. 2013
    b>Intracranial pressure (ICP) monitoring is used extensively in clinical practice, and as such, the accuracy of registered ICP values is paramount...
  43. ncbi Effects of hypervolemia and hypertension on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation after subarachnoid hemorrhage
    Elke Muench
    Department of Anesthesiology, University Hospital Mannheim, Mannheim, Germany
    Crit Care Med 35:1844-51; quiz 1852. 2007
    ..The aim of the study was to investigate the influence of the three arms of triple-H therapy on regional cerebral blood flow and brain tissue oxygenation...
  44. pmc High intracranial pressure effects on cerebral cortical microvascular flow in rats
    Denis E Bragin
    Department of Neurosurgery, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Neurotrauma 28:775-85. 2011
    To manage patients with high intracranial pressure (ICP), clinicians need to know the critical cerebral perfusion pressure (CPP) required to maintain cerebral blood flow (CBF)...
  45. pmc An intracranial pressure-derived index monitored simultaneously from two separate sensors in patients with cerebral bleeds: comparison of findings
    Per Kristian Eide
    Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, and Faculty of Medicine, University of Oslo, Oslo, Norway
    Biomed Eng Online 12:14. 2013
    In an attempt to characterize the intracranial pressure-volume compensatory reserve capacity, the correlation coefficient (R) between the ICP wave amplitude (A) and the ICP (P) level (RAP) has been applied in the surveillance of ..
  46. doi Non-invasive methods of estimating intracranial pressure
    Jamie B Rosenberg
    Department of Ophthalmology and Visual Sciences, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurocrit Care 15:599-608. 2011
    Non-invasive measurement of intracranial pressure can be invaluable in the management of critically ill patients. We performed a comprehensive review of the literature to evaluate the different methods of measuring intracranial pressure...
  47. doi Intracranial pressure: why we monitor it, how to monitor it, what to do with the number and what's the future?
    Andrea Lavinio
    University Division of Anaesthesia, Cambridge University Hospitals Foundation Trust, UK
    Curr Opin Anaesthesiol 24:117-23. 2011
    The review touches upon the current physiopathological concepts relating to the field of intracranial pressure (ICP) monitoring and offers an up-to-date overview of the ICP monitoring technologies and of the signal-analysis techniques ..
  48. doi Monitoring of intracranial pressure in patients with severe traumatic brain injury: an Austrian prospective multicenter study
    Walter Mauritz
    Department of Anaesthesia and Critical Care Medicine, Trauma Hospital Lorenz Boehler, Donaueschingenstrasse 13, 1200, Vienna, Austria
    Intensive Care Med 34:1208-15. 2008
    The goals of this study were to elucidate reasons why patients did or did not receive intracranial pressure (ICP) monitoring and to describe factors influencing hospital mortality after severe traumatic brain injury (TBI).
  49. ncbi Prevention of secondary ischemic insults after severe head injury
    C S Robertson
    Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA
    Crit Care Med 27:2086-95. 1999
    ....
  50. ncbi Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review
    Miriam M Treggiari
    Department of Anesthesiology, Harborview Medical Center, University of Washington School of Medicine, Seattle 98104, USA, and Department of Anesthesiology, Pharmacology, and Intensive Care, Geneva University Hospital, Switzerland
    Neurocrit Care 6:104-12. 2007
    Raised intracranial pressure (ICP) has been consistently associated with poor neurological outcome...
  51. doi Multicenter clinical assessment of the Raumedic Neurovent-P intracranial pressure sensor: a report by the BrainIT group
    Giuseppe Citerio
    Department of Perioperative Medicine and Intensive Care, Ospedale San Gerardo, Monza, Italy
    Neurosurgery 63:1152-8; discussion 1158. 2008
    The aim of this study was to evaluate the robustness and zero-drift of an intracranial pressure sensor, Neurovent-P (Raumedic AG, Münchberg, Germany), when used in the clinical environment.
  52. ncbi Intracranial pressure in patients with sepsis
    D Pfister
    Department of Anaesthesia, Operative Intensive Care Unit, University Hospital Basel, Spitalstrasse 21, CH 4031 Basel, Switzerland
    Acta Neurochir Suppl 102:71-5. 2008
    ..We hypothesized that aggressive fluid administration will increase intracranial pressure (ICP) and may cause critical reductions in cerebral perfusion pressure (CPP).
  53. ncbi Cerebral blood flow autoregulation in experimental liver failure
    Thomas J Dethloff
    Department of Hepatology, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark
    J Cereb Blood Flow Metab 28:916-26. 2008
    ..We measured CBF with laser Doppler, intracranial pressure (ICP) was measured in the fossa posterior and registered with a pressure transducer, brain water was ..
  54. doi Decompressive craniectomy in aneurysmal subarachnoid hemorrhage: relation to cerebral perfusion pressure and metabolism
    Alexandra Nagel
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    Neurocrit Care 11:384-94. 2009
    ..As one treatment option for increased intracranial pressure (ICP), decompressive craniectomy (DC) is discussed...
  55. ncbi Increased intra-abdominal, intrathoracic, and intracranial pressure after severe brain injury: multiple compartment syndrome
    Thomas M Scalea
    R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, MD 21201, USA
    J Trauma 62:647-56; discussion 656. 2007
    ..lung injury may increase intra-abdominal pressure (IAP) and intrathoracic pressure, thereby increasing intracranial pressure (ICP) after traumatic brain injury (TBI)...
  56. doi Novel method for controlling cerebrospinal fluid flow and intracranial pressure by use of a tandem shunt valve system
    Yasuo Aihara
    Department of Neurosurgery, Tokyo Women s Medical University, Tokyo, Japan
    Pediatr Neurosurg 46:12-8. 2010
    ..However, associated problems such as over-drainage and slit-like ventricles, even in patients with anti-siphon devices installed, still remain unresolved...
  57. ncbi The relation between intracranial and intraocular pressures: study of 50 patients
    Seyed A Sajjadi
    School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Ann Neurol 59:867-70. 2006
    ..We evaluated the correlation between intracranial (ICP) and intraocular pressure (IOP)...
  58. doi Ultrasonography of the optic nerve in neurocritically ill patients
    R Moretti
    Department of Anesthesia and Critical Care, Ospedale SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
    Acta Anaesthesiol Scand 55:644-52. 2011
    ..This can rarely be achieved without invasive procedures such as intracranial pressure (ICP) monitoring or neuroimaging...
  59. doi Correlation of intraocular pressure with intracranial pressure in children with severe head injuries
    Thomas Spentzas
    Departments of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    Pediatr Crit Care Med 11:593-8. 2010
    ..correlation between tonometric measurements of the intraocular pressure and transducer measurements of the intracranial pressure in the acute setting, and whether intraocular pressure can be used as a surrogate measure of intracranial ..
  60. ncbi Clinical comparison of tympanic membrane displacement with invasive intracranial pressure measurements
    S Shimbles
    Regional Medical Physics Department and Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Physiol Meas 26:1085-92. 2005
    A non-invasive method of assessing intracranial pressure (ICP) would be of benefit to patients with abnormal cerebral pathology that could give rise to changes in ICP...
  61. doi Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure
    Peter Nissen Bjerring
    Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Denmark
    J Hepatol 53:1054-8. 2010
    ..Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively).
  62. doi Lumbar catheter for monitoring of intracranial pressure in patients with post-hemorrhagic communicating hydrocephalus
    Verena Speck
    Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany
    Neurocrit Care 14:208-15. 2011
    We investigated the feasibility and accuracy of intracranial pressure (ICP)-measurement by lumbar drainage (LD) catheter in patients with post-hemorrhagic communicating hydrocephalus (PHCH).
  63. ncbi A whole-body mathematical model for intracranial pressure dynamics
    William D Lakin
    Department of Mathematics and Statistics, University of Vermont, 16 Colchester Avenue, Burlington 05401 1455, USA
    J Math Biol 46:347-83. 2003
    Most attempts to study intracranial pressure using lumped-parameter models have adopted the classical "Kellie-Monro Doctrine," which considers the intracranial space to be a closed system that is confined within the nearly-rigid skull, ..
  64. ncbi A clinical evaluation of the Codman MicroSensor for intracranial pressure monitoring
    D F Signorini
    Department of Clinical Neurosciences, University of Edinburgh, UK
    Br J Neurosurg 12:223-7. 1998
    The strain-gauge Codman MicroSensor intracranial pressure (ICP) transducer has shown consistently good laboratory performance...
  65. ncbi Noninvasive measurement of intracranial pressure: is it possible?
    Tomasz Czarnik
    Department of Anesthesia and Critical Care, Regional Medical Center, Opole, Poland
    J Trauma 62:207-11. 2007
    Some publications suggest a strong correlation between the intracranial pressure and the intraocular pressure. Other studies claim no correlation between these two physiologic variables...
  66. doi Measurement of intraocular and intracranial pressure: is there a relationship?
    Tyler Kirk
    Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Ann Neurol 70:323-6. 2011
    To study whether noninvasive, intraocular pressure (IOP) measurements significantly correlate with standard intracranial pressure (ICP) measurements.
  67. ncbi Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial
    Nachshon Knoller
    Department of Neurosurgery, Sheba Medical Center, Tel Hashomer, Israel
    Crit Care Med 30:548-54. 2002
    ..To establish the safety of intravenous dexanabinol in severe head injury...
  68. ncbi The jugular foramen in complex and syndromic craniosynostosis and its relationship to raised intracranial pressure
    Philip M Rich
    Department of Neuroradiology, Great Ormond Street Hospital for Children NHS Trust, London, England
    AJNR Am J Neuroradiol 24:45-51. 2003
    Complex and syndromic craniosynostosis can be complicated by raised intracranial pressure (ICP), which in the absence of other identifiable origins, is probably caused by venous hypertension...
  69. doi Lack of correlation among intracerebral cytokines, intracranial pressure, and brain tissue oxygenation in patients with traumatic brain injury and diffuse lesions
    Jon Pérez-Bárcena
    Intensive Care Unit Department, and the Investigation Unit, Son Dureta University Hospital, Palma de Mallorca, Spain
    Crit Care Med 39:533-40. 2011
    ..with traumatic brain injury with diffuse lesions and to study the relationship between cytokines and intracranial pressure, brain tissue oxygenation and lesion type on the computed cranial tomography scan (patients with and ..
  70. doi Reference values for CSF outflow resistance and intracranial pressure in healthy elderly
    Jan Malm
    Department of Clinical Neuroscience, Umea University, SE 901 85 Umea, Sweden
    Neurology 76:903-9. 2011
    The intracranial pressure (ICP) and CSF outflow resistance (R(out)) are essential to describe the dynamics of the CSF system. R(out) affects ICP, pulse amplitudes, CSF absorption, and the compliance of the system...
  71. ncbi The effects of craniosynostosis on the brain with respect to intracranial pressure
    Ruth E Bristol
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 W Thomas Road, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 11:262-7. 2004
    b>Intracranial pressure (ICP) and skull volume are intricately related. Craniosynostosis alters skull volume, and the many forms of craniosynostosis complicate the relationship to ICP even further...
  72. doi Low-level blasts raise intracranial pressure and impair cognitive function in rats
    Annette Säljö
    Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Sahlgren Academy, University of Gothenburg, Gothenburg, Sweden
    J Neurotrauma 26:1345-52. 2009
    ..This study investigates if exposure to occupational levels of low-level blasts affect intracranial pressure and cognitive performance...
  73. ncbi Propofol to control intracranial pressure in fulminant hepatic failure
    E F M Wijdicks
    Department of Neurology and Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Transplant Proc 34:1220-2. 2002
  74. doi Laboratory testing of the Pressio intracranial pressure monitor
    David Allin
    UK Shunt Evaluation Laboratory and Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, England
    Neurosurgery 62:1158-61; discussion 1161. 2008
    The Sophysa Pressio (Sophysa Ltd., Orsay, France) is a new intracranial pressure monitoring system...
  75. doi Is ventriculomegaly in idiopathic normal pressure hydrocephalus associated with a transmantle gradient in pulsatile intracranial pressure?
    Per Kristian Eide
    Department of Neurosurgery, Division of Clinical Neuroscience, Oslo University Hospital, Rikshospitalet HF, 0027 Oslo, Norway
    Acta Neurochir (Wien) 152:989-95. 2010
    ..pressure hydrocephalus (iNPH) and ventriculomegaly, examine whether there is a gradient in pulsatile intracranial pressure (ICP) from within the cerebrospinal fluid (CSF) of cerebral ventricles (ICP(IV)) to the subdural (ICP(SD)) ..
  76. doi Advances in evaluation and management of pediatric idiopathic intracranial hypertension
    Alvit Wolf
    Department of Ophthalmology, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Curr Opin Ophthalmol 19:391-7. 2008
    ..Recent advances in evaluation of optic nerve status make it easier to determine when and if more aggressive intervention is required. Medical and surgical approaches are discussed...
  77. ncbi Macrocephaly, increased intracranial pressure, and hydrocephalus in the infant and young child
    Alexandra T Vertinsky
    Stanford University Medical Center, Stanford, CA, USA
    Top Magn Reson Imaging 18:31-51. 2007
    Macrocephaly, increased intracranial pressure, and hydrocephalus are common related conditions that lead to cross-sectional imaging of the infant and young child...
  78. ncbi Effect of intracranial pressure monitoring and targeted intensive care on functional outcome after severe head injury
    Olaf L Cremer
    Division of Perioperative Care and Emergency Medicine, Department of Neurology, University Medical Center, Utrecht, The Netherlands
    Crit Care Med 33:2207-13. 2005
    ..severe head injury is associated with case fatality, but there is no sound evidence that monitoring of intracranial pressure (ICP) and targeted management of cerebral perfusion pressure (CPP) improve outcome, despite widespread ..
  79. doi Cerebral perfusion pressure in neurotrauma: a review
    Hayden White
    Department of Critical Care, Logan Hospital, Griffiths University, Brisbane, Australia
    Anesth Analg 107:979-88. 2008
    ..As yet, there is no strong outcome evidence to support this approach. Until then, the current debate over the optimal approach to CPP management is likely to continue...
  80. doi Intracranial pressure and glaucoma
    John P Berdahl
    Vance Thompson Vision, 1310 W 22nd Street, Sioux Falls, South Dakota, USA
    Curr Opin Ophthalmol 21:106-11. 2010
    ..Some authors have suggested that the relationship between intraocular pressure and intracranial pressure may play a fundamental role in the development of glaucoma.
  81. pmc Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury
    Roukoz Chamoun
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosurg 113:564-70. 2010
    ..The authors' objective in the present study was to evaluate glutamate levels in TBI, analyzing the factors affecting them and determining their prognostic value...
  82. pmc A dynamic nonlinear relationship between the static and pulsatile components of intracranial pressure in patients with subarachnoid hemorrhage
    Per K Eide
    Department of Neurosurgery, Rikshospitalet University Hospital, Oslo, Norway
    J Neurosurg 112:616-25. 2010
    ..monitoring and predictive tools in neurocritical care, the relationship of the pulsatile component of intracranial pressure (ICP) and the pressure itself has long been of great interest...
  83. ncbi Assessment of the lower limit for cerebral perfusion pressure in severe head injuries by bedside monitoring of regional energy metabolism
    Carl Henrik Nordstrom
    Department of Clinical Neuroscience, Lund University Hospital, Lund, Sweden
    Anesthesiology 98:809-14. 2003
    ....
  84. ncbi Is intracranial pressure waveform analysis useful in the management of pediatric neurosurgical patients?
    P K Eide
    Department of Neurosurgery, Division of Clinical Neuroscience, Rikshospitalet Radiumhospitalet University Hospital, Oslo, Norway
    Pediatr Neurosurg 43:472-81. 2007
    We have reported casuistic observations that intracranial pressure (ICP) waveform analysis may be useful in the management of pediatric patients.
  85. doi Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. Laboratory investigation
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    J Neurosurg 111:978-87. 2009
    ..The purpose of this study was to examine whether the change in intracranial pressure or the extravasated blood causes the late cerebral ischemia and the upregulation of receptors or the ..
  86. ncbi Clinical cerebral microdialysis: a methodological study
    P J Hutchinson
    Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, United Kingdom
    J Neurosurg 93:37-43. 2000
    ....
  87. ncbi Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury
    Marcella Balestreri
    Academic Neurosurgical Unit Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 4:8-13. 2006
    To investigate the relationships between intracranial pressure (ICP), cerebral perfusion pressure (CPP), and outcome after traumatic brain injury.
  88. ncbi Emergency department sonographic measurement of optic nerve sheath diameter to detect findings of increased intracranial pressure in adult head injury patients
    Vivek S Tayal
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Ann Emerg Med 49:508-14. 2007
    ..whether a bedside ultrasonographic measurement of optic nerve sheath diameter can accurately predict the computed tomographic (CT) findings of elevated intracranial pressure in adult head injury patients in the emergency department (ED).
  89. doi Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials
    Hooman Kamel
    Department of Neurology, University of California, San Francisco, CA, USA
    Crit Care Med 39:554-9. 2011
    ..have suggested that hypertonic saline solutions may be superior to mannitol for the treatment of elevated intracranial pressure, but their impact on clinical practice has been limited, partly by their small size...
  90. ncbi Clinical experience with the intraparenchymal intracranial pressure monitoring Codman MicroSensor system
    Lars Owe D Koskinen
    Department of Pharmacology and Clinical Neuroscience, Division of Neurosurgery, Umea University Hospital, Umea, Sweden
    Neurosurgery 56:693-8; discussion 693-8. 2005
    Our main objective was to study the reliability of the Codman MicroSensor (CMS), used for intracranial pressure (ICP) measurements, as it is used in a clinical setting. In particular, the drift from zero was studied.
  91. ncbi Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury
    Luzius A Steiner
    Academic Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Crit Care Med 30:733-8. 2002
    ..To test the hypothesis that patients with poor outcome were managed at a cerebral perfusion pressure (CPP) differing more from their CPPOPT than were patients with good outcome...
  92. ncbi Pediatric idiopathic intracranial hypertension
    Lubaina M Rangwala
    Neuro ophthalmology Services of the Children s Hospital of Philadelphia, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Surv Ophthalmol 52:597-617. 2007
    ..intracranial hypertension in which children should have signs or symptoms consistent with elevated intracranial pressure, be prepubertal, have normal sensorium, can have reversible cranial nerve palsies, and have an opening ..
  93. ncbi CSF pressure assessed by lumbar puncture agrees with intracranial pressure
    N Lenfeldt
    Department of Clinical Neuroscience, Umea University, S 901 85 Umea, Sweden
    Neurology 68:155-8. 2007
    The accuracy of estimating intracranial pressure in brain tissue (ICP(BT)) via lumbar space was investigated using preset pressure levels in the interval 0 to 600 mm H(2)O in patients with communicating hydrocephalus...
  94. ncbi Quantifying the effect of posture on intracranial physiology in humans by MRI flow studies
    Noam Alperin
    Department of Radiology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Magn Reson Imaging 22:591-6. 2005
    ..To quantify the effect of posture on intracranial physiology in humans by MRI, and demonstrate the relationship between intracranial compliance (ICC) and pressure (ICP), and the pulsatility of blood and CSF flows...
  95. ncbi C-tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome
    Frank P Zemlan
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Brain Res 947:131-9. 2002
    ..The present study compared initial CSF C-tau levels, initial Glasgow Coma Scale (GCS) scores and elevated intracranial pressure (ICP) as predictors of clinical outcome...
  96. ncbi Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric stroke
    Stefan Schwarz
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:497-501. 2002
    ..The purpose of this study was to prospectively evaluate the effects of body position in patients with large supratentorial stroke...
  97. ncbi The role of hypothermia in the management of severe brain injury: a meta-analysis
    Odette A Harris
    Department of Neurosurgery, Stanford University Medical Center, 300 Pasteur Dr, Edwards Bldg, Second Floor, Stanford, CA 94305, USA
    Arch Neurol 59:1077-83. 2002
    ..Hypothermia is utilized in the management of severe traumatic brain injury despite the lack of unequivocal evidence supporting its use. Because of its widespread use, the effects of hypothermia are a concern...
  98. doi Optic nerve sheath diameter, intracranial pressure and acute mountain sickness on Mount Everest: a longitudinal cohort study
    A I Sutherland
    Wellcome Research Training Fellow, Nuffield Department of Surgery, Level 6, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Br J Sports Med 42:183-8. 2008
    To investigate the association of optic nerve sheath diameter (ONSD), as a correlate of intracranial pressure (ICP), with acute mountain sickness (AMS).
  99. ncbi Predictive value of initial computerized tomography scan, intracranial pressure, and state of autoregulation in patients with traumatic brain injury
    Magdalena Hiler
    Academic Neurosurgical Unit, Department of Clinical Neuroscience, University of Cambridge, Addenbrooke s NHS Trust, Cambridge, United Kingdom
    J Neurosurg 104:731-7. 2006
    The authors explored the relationship between computerized tomography (CT) scan findings and intracranial pressure (ICP) measurements obtained in the first 24 hours of monitoring to identify parameters predicting outcome in patients with ..
  100. ncbi Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure
    Flemming Tofteng
    Department of Hepatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 26:21-7. 2006
    ..of the osmotic active amino acids glutamine and alanine, processes that were expected to correlate with intracranial pressure (ICP)...
  101. ncbi Frontiers of hypoxia research: acute mountain sickness
    R C Roach
    New Mexico Resonance, Box 343, Montezuma, NM 87731, USA
    J Exp Biol 204:3161-70. 2001
    ..We believe that an examination of the responses of the central nervous system to acute hypoxia will reveal important new pathophysiological processes that may help explain AMS and HACE...

Research Grants65

  1. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..return to the heart and consequently increasing cardiac output and blood pressure and b) uniquely lowering intracranial pressure thereby increasing cerebral perfusion...
  2. Novel non-invasive device for treatment of elevated intracranial pressures
    Keith G Lurie; Fiscal Year: 2011
    ..physiologic events leading to secondary neuronal injury, advances are needed in the treatment of elevated intracranial pressure and decreased cerebral perfusion secondary brain injury...
  3. Decompressive craniotomy versus medical therapy for refractory intracranial hyper
    Raminder Nirula; Fiscal Year: 2010
    ..injury (TBI) management centers upon minimizing secondary brain injury primarily through reducing elevated intracranial pressure.1-4 Therapies to reduce cerebral edema and the discrepancy between cerebral oxygen delivery and ..
  4. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..be, in part, caused by impaired vascular and cerebrospinal fluid (CSF) compliance and resultant abnormal intracranial pressure (ICP) pulsatility...
  5. Novel bundled mechanical and pharmacological CPR platform
    Anja Metzger; Fiscal Year: 2012
    ..output and systemic arterial blood pressure, lowers right atrial and pulmonary artery pressures, lowers intracranial pressure by immediate transference of the negative intrathoracic pressure to the brain, and increases cerebral ..
  6. Resuscitation using novel impedance threshold devices in pediatrics
    Keith G Lurie; Fiscal Year: 2013
    ..Lowering intrathoracic pressure draws venous blood back to the heart and lowers intracranial pressure, thereby increasing systemic and cerebral perfusion...
  7. Effectiveness of ICP Monitoring in Pediatric Traumatic Brain Injury
    TELLEN BENNETT; Fiscal Year: 2013
    ..who will: 1) Improve outcomes in children with TBI by analyzing the effect of interventions (intracranial pressure (ICP) monitoring, osmolar therapy, and others) in the linked dataset developed and validated in this ..
  8. Thoroughfare Channels in CBF Autoregulation at High ICP
    Edwin M Nemoto; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cerebral edema, hyperemia and elevated intracranial pressure (ICP) frequently occur after stroke, traumatic brain injury, cardiac arrest, hepatic encephalopathy, etc...
  9. Neurovascular Protection for Early Brain Injury after SAH
    John H Zhang; Fiscal Year: 2013
    ..Our studies were the pioneering observations that early brain injury which is featured by an elevated intracranial pressure, reduced cerebral blood flow, decreased cerebral perfusion pressure, disrupted blood-brain barrier, ..
  10. Interplay between intrinsic and extrinsic force and glioma aggression
    Matt Barnes; Fiscal Year: 2013
    ..This includes dramatic increases in intracranial pressure as well as stiffening of tumor tissue...
  11. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    CHRISTINA ROSE MARMAROU; Fiscal Year: 2012
    ..Summary Following traumatic brain injury and ischemia, the brain swells due to edema resulting in raised intracranial pressure, neurologic deterioration and in the case of severe swelling, death...
  12. Molecular Mechanisms of Enhanced Contractility following Traumatic Brain Injury:
    Christian W Kreipke; Fiscal Year: 2011
    ..sequelae, TBI results in three major pathologies: 1) cerebral edema which leads to a critical rise in intracranial pressure, 2) diffuse axonal injury which brings about disruption of neural circuits underlying cognitive and ..
  13. Glial-Neural Interactions in Autonomic Control
    Richard C Rogers; Fiscal Year: 2012
    ..While Cushing's ulcer was, for many years, attributed to the effects of increased intracranial pressure on medullary neural circuits that control autonomic outflow to the gut, physiological studies in head ..
  14. Screen for mutations affecting skull and suture formation in zebrafish
    Shannon Fisher; Fiscal Year: 2013
    ..closure of the sutures, craniosynostosis, results in abnormal head shape and is associated with increased intracranial pressure, impaired cerebral blood flow, impaired vision and hearing, and mental disabilities...
  15. Exploring the Physiology of Short-term Control of Cerebral Blood Flow in Humans
    J Andrew Taylor; Fiscal Year: 2011
    ..to neurophysiologic health since too little flow could cause ischemia whereas too much could raise intracranial pressure. Beat-by-beat assessment of cerebral blood flow velocity has shown that cerebral flow is regulated not ..
  16. Chemoprevention of pituitary gonadotrope tumors
    T Rajendra Kumar; Fiscal Year: 2013
    ..include neurological symptoms such as damage to brain tissue and optic chiasm, vision loss, increased intracranial pressure, persistent headache and nausea...
  17. Mechanisms of early brain injury after subarachnoid hemmorrhage
    Guohua Xi; Fiscal Year: 2013
    ..following SAH are complicated including brain edema formation, blood-brain barrier disruption, increased intracranial pressure/brief global cerebral ischemia, and neurotoxicity caused by blood components...
  18. Neuronal Somatic Response to Traumatic Brain Injury
    John T Povlishock; Fiscal Year: 2010
    ..In concert with these descriptive and mechanistic studies, the modulatory effect of elevated intracranial pressure will be assessed as it is an important confound of human TBI...
  19. Trauma-Induced Astrocyte Swelling/Brain Edema: Role of NKCC
    MICHAEL DAVID NORENBERG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Brain edema and associated increase in intracranial pressure are major causes of morbidity and mortality in traumatic brain injury (TBI)...
  20. Tissue Engineering a Suture Replacement for Children with Craniosynostosis
    Gregory M Cooper; Fiscal Year: 2012
    ..often successfully restore normal brain growth vectors, increase intracranial volume, and decrease intracranial pressure, the surgical intervention is extensive and the outcomes are variable...
  21. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..systemic arterial blood pressure, c) lowering right atrial and pulmonary artery pressures, and d) lowering intracranial pressure and thus further increasing cerebral perfusion pressure...
  22. Neurovascular Protection for Subarachnoid Hemorrhage
    John H Zhang; Fiscal Year: 2010
    ..blood-brain barrier (BBB) disruption leading to brain edema, which expands brain volume to increase intracranial pressure, thus decreasing cerebral blood flow, impairing cerebral perfusion and oxygenation, and causing additional ..
  23. Outcomes of Cryptococcal Meningitis in Uganda
    Paul R Bohjanen; Fiscal Year: 2013
    ..In patients with CM, IRIS manifestations include relapsing meningitis, increased intracranial pressure, new focal neurological signs, development of lymphadenopathy, intracranial cryptococcomas, pneumonitis, ..
  24. Hypothalamic Control of IOP, ICP, and the Translaminar Pressure Gradient
    BRIAN CHRISTOPHER SAMUELS; Fiscal Year: 2013
    ..Further, decreases in intracranial pressure (ICP), with postulated increases in the translaminar pressure gradient across the lamina cribrosa, has ..
  25. Nanoparticle-Directed Photothermal Ablation of Primary Brain Tumors guided by Mag
    R Jason Stafford; Fiscal Year: 2012
    ..lead to an enhancement of patients'quality of life as a result of reduced tumor volume and reduced intracranial pressure, which should reduce the incidence of seizures and headaches...
  26. Biochemical Markers of Traumatic Brain Injury
    STEVEN ANDREW ROBICSEK; Fiscal Year: 2010
    ..g. diffuse injury vs. mass lesion), occurrence of secondary insults (e.g. hypotension, elevated intracranial pressure) and outcome (e.g. neurological assessments and MRI)...
  27. HMGB1 and Traumatic Brain Injury
    Krishnan M Dhandapani; Fiscal Year: 2013
    ..Cerebral edema is associated with increased intracranial pressure (ICP) and a poor clinical outcome following TBI, although the cellular mechanisms underlying this process ..
  28. Capacity Building for Decompressive Craniotomy in Colombia
    Juan Carlos Puyana; Fiscal Year: 2013
    ..This disparity is associated with lower levels of technical resources, including monitoring of intracranial pressure (ICP)...
  29. Mild TBI Alters Axonal Structure, Neuronal Electrophysiology &Vascular Function
    John T Povlishock; Fiscal Year: 2013
    ..microvascular abnormalities that lead to sustained vasodilation, lack of vascular responsivity, elevated intracranial pressure, and subsequent reduction of cerebral perfusion pressure...
  30. Host Response to Phenotypic Switch Variants of C. Neoformans
    Bettina Fries; Fiscal Year: 2013
    ..Prior work has associated this switch with virulence including high intracranial pressure and the ability to persist in the host...
  31. A rapid microfluidic P.O.C CNS biomarker platform to predict delayed HICP onset.
    SOMASUNDAR PRASAD GABBITA; Fiscal Year: 2012
    ..POC) prognosticative assay device that provides clinically actionable data to predict onset of high intracranial pressure (HICP) after a severe traumatic brain injury (sTBI)...
  32. Improving Outcomes in Hydrocephalus: Bridging the Gap between Basic Science and C
    James McAllister; Fiscal Year: 2009
    ..longstanding assumptions about the physiologic and pathophysiologic mechanisms of CSF circulation and intracranial pressure (ICP) and pulsatility, with an emphasis on the impact of these mechanisms on brain function in treated and ..
  33. A MEMS intracranial pressure device for monitoring brain injuries and disorders
    NIKOLAOS CHRONIS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Intracranial pressure (ICP) monitoring is an essential diagnostic tool for the efficient treatment of patients with brain injuries (e.g...
  34. CSF Clearance of Intracranial Debris from Traumatic Brain Injury
    Cornelius H Lam; Fiscal Year: 2013
    ..warfare could be violent, with severe brain damage, lacerations of blood vessels, and severe increases in intracranial pressure. Neurosurgeons for decades have recognized the need for control of pressure and mass balance within the ..
  35. Traumatic Brain Injury Clinical Trials Network
    John D Ward; Fiscal Year: 2010
    ..Advances in surgical techniques, management of intracranial pressure, and pharmacological approaches to acute care management helped the Division of Neurosurgery and VCU/MCVH ..
  36. Managing severe TBI without ICP monitoring - guidelines development and testing
    Nancy R Temkin; Fiscal Year: 2013
    ..Guidelines for the Management of Severe Traumatic Brain Injury, 3rd Edition, recommends the use of intracranial pressure (ICP) monitors to assess ICH and to know when and how to intervene...
  37. Treatment of Cerebral Edema using Ventricular Therapy
    JIM STICE; Fiscal Year: 2013
    ..free water out of tissue into the ventricles where it can be removed, thereby reducing cellular swelling, intracranial pressure (ICP), and cell death;ultimately improving cerebral function...
  38. Long Term Implantable ICP Monitor for Hydrocephalus Patients
    Marek Swoboda; Fiscal Year: 2013
    ..This Phase I SBIR will develop ICPCheck, the first long term implantable, non-invasively readable intracranial pressure (ICP) monitor for hydrocephalus patients...
  39. Traumatic Brain Injury Clinical Trials Network-DCC
    William T Friedewald; Fiscal Year: 2011
    ..the development of (i) training programs for the clinical site staffs generally and for the management of intracranial pressure, (ii) a complex, web-based database that will allow the collection and management of data from the trials ..
  40. Development and Early Clinical Evaluation of Noninvasive MRI Measurement of ICP
    Noam Alperin; Fiscal Year: 2011
    ..the clinical utility of a novel method for non-invasive measurement of intracranial compliance (ICC) and intracranial pressure (ICP)...
  41. Longitudinal DTI study in Children Treated for Congenital Hydrocephalus
    Weihong Yuan; Fiscal Year: 2012
    ..and mortality associated with this condition, the potential injury related to pre-operative increased intracranial pressure and the post-operative variability in motor and neurocognitive outcomes are poorly understood...
  42. Continuous-Signal Driven Predictive Models in Neurological Intensive Care Units
    Xiao Hu; Fiscal Year: 2012
    ..insults including acute ventriculomegaly (enlargement of the brain ventricles) and acute elevation of intracranial pressure (ICP) based on integrating, under a novel classifier fusion framework, machine learning algorithms and ..
  43. SURGICAL STUDIES OF SEVERE RESPIRATORY FAILURE
    Joseph Zwischenberger; Fiscal Year: 2004
    ..hypercapnia and the associated respiratory acidosis include increased cardiac output, organ blood flow and intracranial pressure. Arteriovenous carbon dioxide removal (AVCO2R) utilizing a low-resistance gas exchanger in a simple ..
  44. Predictors of recovery from intracerebral hemorrhage in children
    LORI CHAFFIN JORDAN; Fiscal Year: 2012
    ..Aim 2 is to determine if measures of intracranial pressure (ICP) and cerebral autoregulation also predict outcome after childhood ICH...
  45. MEMS-Enabled Ventricular Catheter for Hydrocephalus
    JACK W contact JUDY; Fiscal Year: 2010
    ..Unfortunately, this device, which is critical for lowering intracranial pressure, has a substantial failure rate. A leading cause of failure is the obstruction of the ventricular catheter...
  46. Toward Self-Clearing Ventricular Catheter for Hydrocephalus Application
    HYOWON LEE; Fiscal Year: 2010
    ..Unfortunately, this device, which is critical for lowering intracranial pressure, has a substantial failure rate. A leading cause of failure is the obstruction of the ventricular catheter...
  47. EARLY HEMICRANIECTOMY TO MANAGE TRAUMATIC BRAIN INJURY
    William Coplin; Fiscal Year: 1999
    ..To this end, modern neuro-tensive care expends great effort to control intracranial pressure (ICP) and prevent such secondary injury...
  48. CEREBROVASCULAR ALTERATIONS DURING HYPERAMMONEMIA
    Raymond Koehler; Fiscal Year: 2000
    ..elevations of plasma ammonia levels (approximately 600 muM) in anesthetized rats cause increases in intracranial pressure and cortical water content associated with a tripling of tissue glutamine levels...
  49. REGULATING CEREBROSPINAL FLUID FORMATION
    Barry Hoffer; Fiscal Year: 1992
    Improved medical means of reducing CSF production would be of major benefit to patients with increased intracranial pressure (ICP)...
  50. Non-Invasive Intracranial Pressure Monitor using Otoacoustic Emissions
    PATRICK ALLAN LICHTER; Fiscal Year: 2010
    ..KBT) proposes to develop and evaluate a prototype device that provides non-invasive, real-time intracranial pressure (ICP) monitoring...
  51. Measuring Intra/Extracellular Volume and Hemodynamics
    Leslie Montgomery; Fiscal Year: 2003
    ..pathophysiologic fluid volume and hemodynamic states including, for example, the management of increased intracranial pressure following trauma, the treatment of disequilibrium and hypotension during renal dialysis, the monitoring of ..
  52. SURGICAL CORDIOPULMONARY BYPASS AND CEREBRAL RESISTANCE
    William Johnston; Fiscal Year: 1993
    ..b>Intracranial pressure will be measured directly and intracranial edema formation assessed by brain water content and specific ..
  53. THE EFFECT OF FIBRONECTIN ANTAGONISTS ON OSTEOGENESIS IN
    Amr Moursi; Fiscal Year: 2001
    ..Increased intracranial pressure i the most critical complication, often resulting in poor intellectual development as well as alterations ..
  54. INTRAVENOUS FLUID THERAPY AND HEAD INJURY
    Steven Shackford; Fiscal Year: 1990
    ..This proposal seeks to determine if differences in fluid osmolality and oncotic pressure affect intracranial pressure, cerbral blood flow, cerebral electrical activity and cerebral water content in a procine model of ..
  55. EXCITOTOXIC MECHANISMS IN POST TRAUMATIC NEURONAL DEATH
    Douglas Ross; Fiscal Year: 1992
    ..two components of concussive brain injury, mechanical cortical injury and partial ischemia due to raised intracranial pressure (ICP), will be examined separately and in combination using in vivo animal (rat) models...
  56. ISCHEMIA AND CEREBRAL BLOOD VOLUME IN HUMAN HEAD INJURY
    J Muizelaar; Fiscal Year: 1993
    ..The role of increased cerebral blood volume (CBV) in increasing intracranial pressure (ICP) or "brain stiffness"...
  57. NATIONAL ACUTE BRAIN INJURY STUDY--HYPOTHERMIA
    Guy Clifton; Fiscal Year: 1999
    ..Patients are managed with a standard protocol of sedation, aggressive management of intracranial pressure/cerebral perfusion pressure, nutrition, and measures to prevent complications...
  58. Intrathoracic Pressure Regulator for Resuscitation
    Keith Lurie; Fiscal Year: 2006
    ..Simultaneously this device lowers intracranial pressure. Preliminary animal studies with the ITPR demonstrate that mean arterial pressures as well as coronary and ..
  59. Fibronectin Antagonists in Cranial Suture Formation
    Amr Moursi; Fiscal Year: 2006
    ..Increased intracranial pressure is the most critical complication, often resulting in poor intellectual development as well as alterations ..
  60. AMINO ACID TRANSPORT IN HYPERAMMONEMIC CONDITIONS
    James Olson; Fiscal Year: 1993
    ..Cerebral edema and elevated intracranial pressure is a consistent finding in HE...
  61. MECHANISMS OF BRAIN DEHYDRATION WITH OSMOTIC DIURETICS
    Stanley Nelson; Fiscal Year: 1980
    The osmotic diuretics can be relied upon to reduce intracranial pressure in patients wth conditons such as brain tumors and cerebral trauma...
  62. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    Anthony Marmarou; Fiscal Year: 2007
    Following traumatic brain injury and ischemia, the brain swells due to edema resulting in raised intracranial pressure, neurologic deterioration and in the case of severe swelling, death...
  63. GENE-BASED THERAPIES AND IMAGING OF MALIGNANT GLIOMAS
    Kevin Judy; Fiscal Year: 2003
    ..The dose limiting toxicity resulted from an increase in intracranial pressure believed to be secondary to virus induced inflammation...
  64. Magnesium as a Neuroprotective Agent for Pediatric TBI
    DONALD SHAFFNER; Fiscal Year: 2002
    ..placebo-controlled trial of magnesium in children with severe TBI who require intensive care and intracranial pressure monitoring...
  65. EPIDEMIOLOGIC RESEARCH IN NEURO-OPHTHALMOLOGY
    Laura Balcer; Fiscal Year: 2000
    ..risk factors/associations and potential treatments for pseudotumor cerebri, a condition of elevated intracranial pressure of unknown etiology which can result in severe and permanent visual loss...