exercise tolerance

Summary

Summary: The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.

Top Publications

  1. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
  2. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006
  3. ncbi Physical activity in patients with COPD
    H Watz
    Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, Grosshansdorf, Germany
    Eur Respir J 33:262-72. 2009
  4. ncbi Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD
    Koichi Nishimura
    Respiratory Division, Kyoto Katsura Hospital, Kyoto, Japan
    Chest 121:1434-40. 2002
  5. ncbi Effect of indacaterol on exercise endurance and lung hyperinflation in COPD
    Denis E O'Donnell
    Queen s University and Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Respir Med 105:1030-6. 2011
  6. ncbi Daily physical activity in patients with chronic obstructive pulmonary disease is mainly associated with dynamic hyperinflation
    Francisco Garcia-Rio
    Servicio de Neumologia, Hospital Universitario La Paz, Madrid, Spain
    Am J Respir Crit Care Med 180:506-12. 2009
  7. ncbi Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Proc Am Thorac Soc 3:180-4. 2006
  8. ncbi Interpretation of treatment changes in 6-minute walk distance in patients with COPD
    M A Puhan
    Horten Centre, University Hospital of Zurich, Postfach Nord, CH 8091 Zurich, Switzerland
    Eur Respir J 32:637-43. 2008
  9. ncbi Indacaterol add-on therapy improves lung function, exercise capacity and life quality of COPD patients
    R M Mroz
    Department of Lung Diseases, Medical University of Bialystok, Zurawia 14, Bialystok, Poland
    Adv Exp Med Biol 756:23-8. 2013
  10. ncbi Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index
    Milo A Puhan
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 374:704-11. 2009

Detail Information

Publications369 found, 100 shown here

  1. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    ..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
  2. ncbi American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
    Linda Nici
    Am J Respir Crit Care Med 173:1390-413. 2006
  3. ncbi Physical activity in patients with COPD
    H Watz
    Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, Grosshansdorf, Germany
    Eur Respir J 33:262-72. 2009
    ..Clinical characteristics of patients with chronic obstructive pulmonary disease only incompletely reflect their physical activity...
  4. ncbi Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD
    Koichi Nishimura
    Respiratory Division, Kyoto Katsura Hospital, Kyoto, Japan
    Chest 121:1434-40. 2002
    ....
  5. ncbi Effect of indacaterol on exercise endurance and lung hyperinflation in COPD
    Denis E O'Donnell
    Queen s University and Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Respir Med 105:1030-6. 2011
    ..This study investigated the effect of indacaterol on exercise endurance, and on lung hyperinflation during exercise and at rest in patients with moderate-to-severe COPD...
  6. ncbi Daily physical activity in patients with chronic obstructive pulmonary disease is mainly associated with dynamic hyperinflation
    Francisco Garcia-Rio
    Servicio de Neumologia, Hospital Universitario La Paz, Madrid, Spain
    Am J Respir Crit Care Med 180:506-12. 2009
    ..Although the major limitation to exercise performance in patients with COPD is dynamic hyperinflation, little is known about its relation to daily physical activity...
  7. ncbi Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Proc Am Thorac Soc 3:180-4. 2006
    ..This lung deflation allows greater Vt expansion for a given inspiratory effort during exercise with consequent improvement in dyspnea and exercise endurance...
  8. ncbi Interpretation of treatment changes in 6-minute walk distance in patients with COPD
    M A Puhan
    Horten Centre, University Hospital of Zurich, Postfach Nord, CH 8091 Zurich, Switzerland
    Eur Respir J 32:637-43. 2008
    ..This corresponds to a 10% change of baseline 6-min walk distance. The low correlations of 6-min walk distance with patient-reported anchors question whether a minimal important difference exists for the 6-min walk distance...
  9. ncbi Indacaterol add-on therapy improves lung function, exercise capacity and life quality of COPD patients
    R M Mroz
    Department of Lung Diseases, Medical University of Bialystok, Zurawia 14, Bialystok, Poland
    Adv Exp Med Biol 756:23-8. 2013
    ..The disease leads to airflow limitation, and pulmonary hyperinflation, resulting in dyspnea, decreased exercise tolerance, and impaired quality of life...
  10. ncbi Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index
    Milo A Puhan
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 374:704-11. 2009
    ..We assessed the calibration of the BODE index, updated it to improve its calibration, and developed and validated a simplified index for use in primary-care settings...
  11. ncbi Strategies of muscle training in very severe COPD patients
    I Vogiatzis
    Department of Physical Education and Sport Sciences, National and Kapodistrian University of Athens, Athens, Greece
    Eur Respir J 38:971-5. 2011
    ..strong evidence that exercise training, constituting the cornerstone of pulmonary rehabilitation, improves exercise tolerance, dyspnoea sensations, functional capacity and quality of life in patients with severe chronic obstructive ..
  12. ncbi Are patients with COPD more active after pulmonary rehabilitation?
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Chest 134:273-80. 2008
    ..Despite a variety of benefits brought by pulmonary rehabilitation to patients with COPD, it is unclear whether these patients are more active during daily life after the program...
  13. pmc Peripheral muscle endurance and the oxidative profile of the quadriceps in patients with COPD
    J Allaire
    Centre de Recherches Cliniques, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, QC, Canada G1V 4G5
    Thorax 59:673-8. 2004
    ....
  14. ncbi Cardiovascular risk factors emerge after artificial selection for low aerobic capacity
    Ulrik Wisløff
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt 3, 7489 Trondheim, Norway
    Science 307:418-20. 2005
    ..Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease...
  15. ncbi Altitude and endurance training
    Heikki K Rusko
    KIHU Research Institute for Olympic Sports, Jyvaskyla, Finland
    J Sports Sci 22:928-44; discussion 945. 2004
    ..The effects of hypoxic training and intermittent short-term severe hypoxia at rest are not yet clear and they require further study...
  16. ncbi Pulmonary rehabilitation in chronic obstructive pulmonary disease
    Thierry Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 172:19-38. 2005
  17. ncbi Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial
    Darlington O Okonko
    Clinical Cardiology, NHLI, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 51:103-12. 2008
    We tested the hypothesis that intravenous iron improves exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure (CHF) and iron deficiency.
  18. pmc Exercise training for systolic heart failure: Cochrane systematic review and meta-analysis
    Edward J Davies
    Cardiothoracic Department, Plymouth Hospitals NHS Trust, Terrance Lewis Building, 9th Floor, Derriford Hospital, Plymouth Hospitals NHS Trust, Derriford Road, Crownhill, Plymouth, Devon PL6 8DH, UK
    Eur J Heart Fail 12:706-15. 2010
    ..To determine the effect of exercise training on clinical events and health-related quality of life (HRQoL) of patients with systolic heart failure...
  19. doi The major limitation to exercise performance in COPD is dynamic hyperinflation
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol 105:753-5; discussion 755-7. 2008
  20. ncbi Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
    J Mark Davis
    University of South Carolina, Department of Exercise Science, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1071-7. 2009
    ..In addition, the in vivo effects of quercetin on mitochondrial biogenesis exercise tolerance are unknown...
  21. pmc Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial
    Kai M Beeh
    insaf Respiratory Research Institute, Wiesbaden, Germany
    Int J Chron Obstruct Pulmon Dis 7:503-13. 2012
    ..We assessed the effects of glycopyrronium bromide (NVA237), a once-daily, long-acting muscarinic antagonist, on exercise tolerance in patients with moderate to severe COPD.
  22. pmc Insulin resistance and exercise tolerance in heart failure patients: linkage to coronary flow reserve and peripheral vascular function
    Martin Snoer
    Dept Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark
    Cardiovasc Diabetol 11:97. 2012
    ..The aim of this study was to assess the potential role of coronary flow reserve (CFR), endothelial function and arterial stiffness in explaining this linkage...
  23. ncbi Exercise pathophysiology in patients with primary pulmonary hypertension
    X G Sun
    Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
    Circulation 104:429-35. 2001
    ..CONCLUSIONS: Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class...
  24. pmc Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations
    Thomas Glaab
    Pulmonary Department, University Hospital, Johannes Gutenberg University, Mainz, Germany
    Respir Res 11:79. 2010
    ....
  25. ncbi Intermittent hypoxia increases exercise tolerance in elderly men with and without coronary artery disease
    Martin Burtscher
    Department of Sport Science, Medical Section, University of Innsbruck, Fürstenweg 185, 6020 Innsbruck, Austria
    Int J Cardiol 96:247-54. 2004
    Intermittent hypoxia has been suggested to increase exercise tolerance by enhancing stress resistance and improving oxygen delivery...
  26. ncbi Iron deficiency predicts impaired exercise capacity in patients with systolic chronic heart failure
    Ewa A Jankowska
    Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland
    J Card Fail 17:899-906. 2011
    ..Hence, iron deficiency (ID) is anticipated to limit exercise capacity. We investigated whether ID predicted exercise intolerance in patients with systolic chronic heart failure (CHF)...
  27. ncbi Influence of pacing strategy on O2 uptake and exercise tolerance
    A M Jones
    School of Sport and Health Sciences, University of Exeter, Exeter, Devon, UK
    Scand J Med Sci Sports 18:615-26. 2008
    ..84 L; P<0.05 for FS vs ES and SS). These results suggest that a fast-start pacing strategy might enhance exercise tolerance by increasing the oxidative contribution to energy turnover and hence "sparing" some of the finite anaerobic ..
  28. pmc Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects
    S Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, PA 15238, USA
    Thorax 61:10-6. 2006
    ..Inflammatory markers are increased in chronic obstructive pulmonary disease (COPD) and are hypothesised to play an important part in muscle dysfunction and exercise intolerance...
  29. ncbi Respiratory muscle training improves cardiopulmonary function and exercise tolerance in subjects with subacute stroke: a randomized controlled trial
    Serap Tomruk Sutbeyaz
    Fourth Physical Medicine and Rehabilitation Clinic, Ankara Physical Medicine and Rehabilitation Education and Research Hospital, Ankara, Turkey
    Clin Rehabil 24:240-50. 2010
    To determine whether two types of exercise--breathing retraining (BRT) and inspiratory muscle training (IMT)--improve on cardiopulmonary functions and exercise tolerance in patients with stroke.
  30. ncbi Bosentan therapy for pulmonary arterial hypertension
    Lewis J Rubin
    Division of Pulmonary and Critical Care Medicine, University of California at San Diego, La Jolla 92037 1330, USA
    N Engl J Med 346:896-903. 2002
    ..The present trial investigated the effect of bosentan on exercise capacity in a larger number of patients and compared two doses...
  31. ncbi Randomized controlled study of in-hospital exercise training programs in children with cystic fibrosis
    H C Selvadurai
    Children s Chest Research Centre and Department of Respiratory Medicine, Royal Alexandra Hospital for Children, New South Wales, Australia
    Pediatr Pulmonol 33:194-200. 2002
    ..A combination of aerobic and resistance training may be the best training program, and future studies to assess optimal training programs for CF patients are indicated...
  32. ncbi Evidence for prescribing exercise as therapy in chronic disease
    B K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Copenhagen, Denmark
    Scand J Med Sci Sports 16:3-63. 2006
    ..The possible mechanisms of action are briefly examined and the principles for prescribing exercise therapy are discussed, focusing on the type and amount of exercise and possible contraindications...
  33. ncbi Exercise and heart failure: A statement from the American Heart Association Committee on exercise, rehabilitation, and prevention
    Ileana L Pina
    Circulation 107:1210-25. 2003
  34. ncbi Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency
    Jorge Eduardo Toblli
    Hospital Aleman, Buenos Aires, Argentina
    J Am Coll Cardiol 50:1657-65. 2007
    ....
  35. ncbi Effect of indacaterol on dynamic lung hyperinflation and breathlessness in hyperinflated patients with COPD
    Kai Michael Beeh
    insaf Respiratory Research Institute, D 65187 Wiesbaden, Germany
    COPD 8:340-5. 2011
    ..In conclusion, indacaterol 300 μg administered once-daily showed a clinically relevant increase in IC after 14 days of treatment, reflecting a reduction in dynamic hyperinflation...
  36. ncbi Sildenafil citrate therapy for pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    N Engl J Med 353:2148-57. 2005
    ....
  37. ncbi Short term improvement in exercise capacity and symptoms following exercise training in interstitial lung disease
    A E Holland
    Physiotherapy Department, Alfred Hospital, Commercial Rd, Melbourne, Australia 3004
    Thorax 63:549-54. 2008
    ....
  38. ncbi Dehydration and rehydration in competative sport
    R J Maughan
    School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
    Scand J Med Sci Sports 20:40-7. 2010
    ..An appropriate, individualized drinking strategy will take account of pre-exercise hydration status and of fluid, electrolyte and substrate needs before, during and after a period of exercise...
  39. ncbi Optimizing the "priming" effect: influence of prior exercise intensity and recovery duration on O2 uptake kinetics and severe-intensity exercise tolerance
    Stephen J Bailey
    School of Sport and Health Sciences, St Luke s Campus, University of Exeter, Devon, UK
    J Appl Physiol (1985) 107:1743-56. 2009
    ..b>Exercise tolerance at 80%Delta was improved by 15% and 30% above control in the 70-9-80 and 70-20-80 conditions, respectively, ..
  40. ncbi Effectiveness of exercise training in patients with COPD: the role of muscle fatigue
    Chris Burtin
    Faculty of Kinesiology and Rehabilitation Sciences, Dept of Rehabilitation Sciences, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 40:338-44. 2012
    ..Patients who develop quadriceps contractile fatigue during exercise training show greater training effects in terms of functional exercise capacity and health-related quality of life...
  41. pmc Improving the quality of life in patients with chronic obstructive pulmonary disease: focus on indacaterol
    Gregory J Feldman
    S Carolina Pharmaceutical Research, Alliance Biomedical Group International, Spartanburg, SC 29303, USA
    Int J Chron Obstruct Pulmon Dis 8:89-96. 2013
    ..COPD state that the goals of pharmacologic therapy should be to control symptoms, improve health status and exercise tolerance, and reduce the frequency of COPD exacerbations...
  42. ncbi The effects of 1 year of specific inspiratory muscle training in patients with COPD
    Marinella Beckerman
    Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel
    Chest 128:3177-82. 2005
    ..We assessed the long-term benefits of inspiratory muscle training (IMT) on inspiratory muscle strength, exercise capacity, the perception of dyspnea, quality of life, primary care use, and hospitalizations in patients with significant COPD...
  43. ncbi Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
    ..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment...
  44. ncbi Effects of prior very-heavy intensity exercise on indices of aerobic function and high-intensity exercise tolerance
    C Ferguson
    Centre for Sport and Exercise Sciences, Institute of Membrane and Systems Biology, Worsley Bldg, Univ of Leeds, Leeds, LS2 9JT, United Kingdom
    J Appl Physiol 103:812-22. 2007
    ..These results suggest that, following supra-CP priming, there is either a reduced depletable energy resource or a residual fatigue-metabolite level that leads to the tolerable limit before this resource is fully depleted...
  45. ncbi Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice
    Alessandra Medeiros
    School of Physical Education and Sport, University of Sao Paulo, Brazil
    J Appl Physiol (1985) 104:103-9. 2008
    ..At 3 mo of age, no significant difference in FS and exercise tolerance was observed between WT and alpha(2A)/alpha(2C)ARKO mice...
  46. ncbi Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity
    Stephane P Dufour
    Département de Physiologie et des Explorations Fonctionnelles, Hopital Civil, and Faculté de Médicine, Institut de Physiologie, Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil, 3072 Strasbourg, France
    J Appl Physiol 100:1238-48. 2006
    ....
  47. ncbi Effects of Tai Chi training on exercise capacity and quality of life in patients with chronic heart failure: a meta-analysis
    Lei Pan
    State Key Laboratory of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical College, 151 Yanjiang Road, Guangzhou 510120, PR China
    Eur J Heart Fail 15:316-23. 2013
    ..We performed a meta-analysis to examine the effects of TC on exercise capacity and quality of life (QoL) in CHF patients...
  48. ncbi Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 164:770-7. 2001
    ..DH curtailed the VT response to exercise. This inability to expand VT in response to increasing metabolic demand contributed importantly to exercise intolerance in COPD...
  49. pmc Sustained effects of integrated COPD management on health status and exercise capacity in primary care patients
    Annemarije L Kruis
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden
    Int J Chron Obstruct Pulmon Dis 5:407-13. 2010
    ..Integrated disease management (IDM) of mild to moderate COPD patients has been demonstrated to improve exercise capacity and health status after one year, but long-term results are currently lacking in primary care...
  50. ncbi Impact of pulmonary hypertension on gas exchange and exercise capacity in patients with pulmonary fibrosis
    Sven Glaser
    Division of Pulmonary Medicine and Infectious Diseases, University of Greifswald, Sauerbruchstrasse, 17475 Greifswald, Germany
    Respir Med 103:317-24. 2009
    ..is a relevant interceding morbidity in patients with pulmonary fibrosis that has significant impact on exercise tolerance and outcome...
  51. ncbi Iloprost improves gas exchange and exercise tolerance in patients with pulmonary hypertension and chronic obstructive pulmonary disease
    Tarek A Dernaika
    University of Oklahoma Health Sciences Center, Pulmonary and Critical Care Medicine, Oklahoma City, OK 73104, USA
    Respiration 79:377-82. 2010
    ..Inhaled iloprost has the potential to act preferentially in ventilated regions of the lung, thereby reducing pulmonary hypertension (PH) while alveolar ventilation is still maintained...
  52. ncbi Six-minute walk test and cardiopulmonary exercise testing in patients with chronic heart failure: a comparative analysis on clinical and prognostic insights
    Marco Guazzi
    Cardiopulmonary Unit, University of Milano, Italy
    Circ Heart Fail 2:549-55. 2009
    ..A comprehensive comparison on clinical and prognostic validity of the 2 techniques has not been performed and is the aim of the present investigation...
  53. ncbi Systematic review and meta-analysis of exercise tolerance and physical functioning in dialysis patients treated with erythropoiesis-stimulating agents
    Kirsten L Johansen
    University of California, San Francisco, CA, USA
    Am J Kidney Dis 55:535-48. 2010
    ..This potential increased risk needs to be weighed against the potential benefit of ESAs in improving various aspects of health-related quality of life, in particular, exercise tolerance and physical functioning.
  54. ncbi Pulmonary rehabilitation is successful for COPD irrespective of MRC dyspnoea grade
    R A Evans
    Dept of Respiratory Medicine, Allergy and Thoracic Surgery, University Hospitals of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom
    Respir Med 103:1070-5. 2009
    ..We have therefore investigated the effect of pulmonary rehabilitation stratified by the MRC dyspnoea scale in patients with COPD...
  55. ncbi Iron supplementation for the treatment of chronic heart failure and iron deficiency: systematic review and meta-analysis
    Tomer Avni
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Eur J Heart Fail 14:423-9. 2012
    ..Over half of chronic heart failure (CHF) patients are anaemic, and iron deficiency is common. Iron replacement therapy (oral or i.v.) might improve exercise capacity and quality of life (QOL)...
  56. ncbi A better response in exercise capacity after pulmonary rehabilitation in more severe COPD patients
    Wytske A Altenburg
    Department of Pulmonary Diseases, University Medical Centre Groningen, University of Groningen, P O Box 30001, Internal mail address AA11, 9700 RB Groningen, The Netherlands
    Respir Med 106:694-700. 2012
    ..However, not all COPD patients benefit from PR to the same extent. We investigated whether there is a patient profile, which is associated with the improvement in endurance exercise capacity...
  57. ncbi Exercise intolerance in mitochondrial myopathy is not related to lactic acidosis
    J Vissing
    Department of Neurology, National University Hospital, Rigshospitalet, Copenhagen, Denmark
    Ann Neurol 49:672-6. 2001
    ..myopathy patients (MM), we investigated whether lowering of lactate with dichloroacetate (DCA) can improve exercise tolerance and oxidative capacity in MM. DCA lowered plasma lactate at rest and during exercise (from 10.5 +/- 2.0 to 5...
  58. ncbi Exercise tolerance in children and adolescents with musculoskeletal pain in joint hypermobility and joint hypomobility syndrome
    Raoul H H Engelbert
    Department of Pediatric Physical Therapy and Pediatric Exercise Physiology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, Netherlands
    Pediatrics 118:e690-6. 2006
    Musculoskeletal pain is a common complaint in a pediatric health care practice, but exercise tolerance has never been described in detail in these children...
  59. ncbi Functional and muscular effects of neuromuscular electrical stimulation in patients with severe COPD: a randomized clinical trial
    Isabelle Vivodtzev
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    Chest 141:716-25. 2012
    ..through which neuromuscular electrical stimulation (NMES) training may improve limb muscle function and exercise tolerance in COPD are poorly understood. We investigated the functional and muscular effects of NMES in advanced COPD.
  60. ncbi Aerobic and anaerobic exercise capacity in adolescents with juvenile idiopathic arthritis
    Otto T H M Lelieveld
    University Medical Center Groningen, The Netherlands
    Arthritis Rheum 57:898-904. 2007
    ....
  61. ncbi Metabolic profile and exercise capacity outcomes: their relationship to overweight and obesity in a Canadian cardiac rehabilitation setting
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    J Cardiopulm Rehabil 24:405-13. 2004
    ....
  62. ncbi Effect of obesity on respiratory mechanics during rest and exercise in COPD
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    J Appl Physiol (1985) 111:10-9. 2011
    ..Potential contributory factors included alterations in the elastic properties of the lungs, raised intra-abdominal pressures, reduced lung hyperinflation, and preserved inspiratory capacity...
  63. pmc Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial
    Deepa Sumukadas
    Section of Ageing and Health, University of Dundee, Dundee, UK
    CMAJ 177:867-74. 2007
    ..We sought to examine the effect of the angiotensin-converting-enzyme (ACE) inhibitor perindopril on physical function in elderly people with functional impairment who had no heart failure or left ventricular systolic dysfunction...
  64. ncbi Aerobic and anaerobic exercise capacity in children with juvenile idiopathic arthritis
    M van Brussel
    University Hospital for Children and Youth Wilhelmina Kinderziekenhuis, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 57:891-7. 2007
    ....
  65. ncbi High value of combined serum C-reactive protein and BODE score for mortality prediction in patients with stable COPD
    Shih Feng Liu
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan, China
    Arch Bronconeumol 47:427-32. 2011
    ..The aim of this study is to investigate the predictive value of combined serum CRP and BODE score for mortality in COPD patients...
  66. ncbi Home-based pulmonary rehabilitation in chronic obstructive pulmonary disease patients
    Danielle S R Vieira
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Curr Opin Pulm Med 16:134-43. 2010
    ....
  67. ncbi Heliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary disease
    Gaspar R Chiappa
    Pulmonary Function and Clinical Exercise Physiology Unit SEFICE, Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
    Am J Respir Crit Care Med 179:1004-10. 2009
    Normoxic heliox (mixture of 79% He and 21% O(2)) may enhance exercise tolerance in patients with chronic obstructive pulmonary disease (COPD)...
  68. pmc Relationship of Doppler-Echocardiographic left ventricular diastolic function to exercise performance in systolic heart failure: the HF-ACTION study
    Julius M Gardin
    St John Hospital and Medical Center, Detroit, MI Hackensack University Medical Center, Hackensack, NJ 07601, USA
    Am Heart J 158:S45-52. 2009
    ..Although in animal models diastolic dysfunction is associated with worsening exercise capacity and prognosis, information regarding these relationships in patients with established systolic heart failure (HF) is sparse...
  69. pmc Impact of bronchodilator therapy on exercise tolerance in COPD
    B Aguilaniu
    HYLAB, Laboratory of Clinical Physiology and Exercise, Grenoble, France
    Int J Chron Obstruct Pulmon Dis 5:57-71. 2010
    b>Exercise tolerance is an important parameter in patients with COPD and a primary goal of treatment is to reduce dyspnea to facilitate physical activities and improve health-related quality of life...
  70. ncbi Helium-hyperoxia, exercise, and respiratory mechanics in chronic obstructive pulmonary disease
    Neil D Eves
    Rehabilitation Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4
    Am J Respir Crit Care Med 174:763-71. 2006
    Hyperoxia and normoxic helium independently reduce dynamic hyperinflation and improve the exercise tolerance of patients with chronic obstructive pulmonary disease (COPD)...
  71. ncbi Relationship between exercise tolerance and muscle strength following cardiac rehabilitation: comparison of patients after cardiac surgery and patients with myocardial infarction
    Takahiro Sumide
    Juntendo Sports Clinic, Juntendo University Hospital, 3 1 3 Hongo, Bunkyo ku, Tokyo 113 8431, Japan
    J Cardiol 54:273-81. 2009
    Previous studies have demonstrated that cardiac rehabilitation (CR) improves exercise tolerance and muscle strength in patients with myocardial infarction (MI) and in patients after cardiac surgery...
  72. ncbi L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs
    A Borghi-Silva
    Laboratório de Fisioterapia Cardiovascular, Universidade Federal de Sao Carlos, Sao Carlos, SP, Brazil
    Braz J Med Biol Res 39:465-74. 2006
    ..Nutritional status, exercise tolerance on a treadmill and six-minute walking test, blood lactate, heart rate, blood pressure, and respiratory ..
  73. ncbi Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis
    T Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 33:99-106. 2009
    ..muscle weakness and the importance of physical inactivity in cystic fibrosis (CF), and its relationship to exercise tolerance and muscle strength...
  74. ncbi Task-related oxygen uptake during domestic activities of daily life in patients with COPD and healthy elderly subjects
    Anouk W Vaes
    Program Development Centre, CIRO, Horn, The Netherlands
    Chest 140:970-9. 2011
    ....
  75. ncbi Decreasing cardiac chamber sizes and associated heart dysfunction in COPD: role of hyperinflation
    Henrik Watz
    Pulmonary Research Institute, Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, D 22927 Grosshansdorf, Germany
    Chest 138:32-8. 2010
    ..We studied the relationship of lung function with heart size and heart dysfunction and associated consequences for 6-min walk distance (6MWD) in patients with COPD of different severitites...
  76. ncbi Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Ontario, Canada
    Eur Respir J 23:832-40. 2004
    ..Resultant increases in inspiratory capacity permitted greater expansion of tidal volume and contributed to improvements in both exertional dyspnoea and exercise endurance...
  77. ncbi Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia
    Jalal K Ghali
    Wayne State University, Detroit, Mich, USA
    Circulation 117:526-35. 2008
    ..The Study of Anemia in Heart Failure Trial (STAMINA-HeFT) is the largest multicenter, randomized, double-blind, placebo-controlled trial to date evaluating the effect of treating anemia in HF...
  78. ncbi Dyspnea and activity limitation in COPD: mechanical factors
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    COPD 4:225-36. 2007
    ....
  79. ncbi Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD?
    Jordan A Guenette
    Respiratory Investigation Unit, Queen s University and Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada
    Eur Respir J 40:322-9. 2012
    ..It is not known whether the presence or absence of DH has implications for dyspnoea and exercise tolerance. Therefore, we compared detailed ventilatory and sensory responses to exercise in hyperinflators and ..
  80. ncbi Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD
    Francois Maltais
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, 2725 Chemin Sainte Foy, Quebec G1V 4G5, Canada
    Respir Med 105:580-7. 2011
    ..Static and dynamic lung hyperinflation are associated with exercise impairment and poor outcomes in COPD patients. Aclidinium bromide is a novel, long-acting inhaled muscarinic antagonist currently in development for COPD treatment...
  81. pmc Impact of pulmonary artery pressure on exercise function in severe COPD
    Michael W Sims
    Department of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:412-9. 2009
    ..Although pulmonary hypertension commonly complicates COPD, the functional consequences of increased pulmonary artery pressures in patients with this condition remain poorly defined...
  82. ncbi Effects of whole body vibration in patients with chronic obstructive pulmonary disease--a randomized controlled trial
    Rainer Gloeckl
    Department of Respiratory Medicine, Schoen Klinik Hospital, Schoenau am Koenigssee, Germany
    Respir Med 106:75-83. 2012
    ..Additional whole body vibration training during pulmonary rehabilitation may be such a new approach that has not yet been investigated in patients with COPD...
  83. ncbi Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort
    Martijn A Spruit
    Program Development Centre, CIRO, a centre of excellence for chronic organ failure, Horn, The Netherlands
    Respir Med 104:849-57. 2010
    The 6-min walking test (6MWT) is widely used to assess exercise tolerance in patients with chronic obstructive pulmonary disease (COPD)...
  84. ncbi Effects of exercise training in patients with idiopathic pulmonary arterial hypertension
    F S de Man
    Dept of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Eur Respir J 34:669-75. 2009
    ..No changes were found in cross-sectional area and fibre type distribution. Exercise training in iPAH improves exercise endurance and quadriceps muscle function, which is also reflected by structural changes of the quadriceps...
  85. ncbi Outpatient pulmonary rehabilitation following acute exacerbations of COPD
    John M Seymour
    Department of Respiratory Medicine, King s College Hospital, London SE5 9RJ, UK
    Thorax 65:423-8. 2010
    ..28, 95% CI 0.10 to 0.82, p=0.02). CONCLUSIONS Post-exacerbation rehabilitation in COPD can reduce re-exacerbation events that require admission or hospital attendance over a 3-month period. Clinical Trials Registration Number NCT00557115...
  86. ncbi Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival
    Olivier Sitbon
    Service de Pneumologie et Reanimation, UPRES EA 2705 on Pulmonary Vascular Diseases, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    J Am Coll Cardiol 40:780-8. 2002
    ..We sought to determine the factors associated with long-term survival in patients with primary pulmonary hypertension (PPH) treated with continuous epoprostenol infusion...
  87. ncbi Recommendations on the use of exercise testing in clinical practice
    P Palange
    Servizio di Fisiopatologia Respiratoria, Dipartimento di Medicina Clinica, University of Rome La Sapienza, Rome, Italy
    Eur Respir J 29:185-209. 2007
    ..intolerance be sought?"; 2) "Which particular form of test should be asked for?"; and 3) "What cluster of variables should be selected when evaluating prognosis for a particular disease or the effect of a particular intervention?"..
  88. ncbi Development of an unsupported arm exercise test in patients with chronic obstructive pulmonary disease
    Su Zhan
    SUNY Buffalo, NY, USA
    J Cardiopulm Rehabil 26:180-7; discussion 188-90. 2006
    ..Unsupported arm exercise tests have been used to evaluate the effects of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD), but the reliability and validity of these tests are not established...
  89. ncbi Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 170:870-8. 2004
    ..Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels...
  90. ncbi Six-minute walk distance as a measure of functional exercise capacity in multiple sclerosis
    Sema Savci
    School of Physical Therapy and Rehabilitation, Hacettepe University, 16100 Samanpazari, Ankara, Turkey
    Disabil Rehabil 27:1365-71. 2005
    ..We also investigated the contribution of demographic, physical and physiological factors to impaired functional capacity in MS...
  91. ncbi The effect of exercise training on anxiety symptoms among patients: a systematic review
    Matthew P Herring
    Department of Kinesiology, Ramsey Center, The University of Georgia, 330 River Road, Athens, GA 30602 6554, USA
    Arch Intern Med 170:321-31. 2010
    ..We estimated the population effect size for exercise training effects on anxiety and determined whether selected variables of theoretical or practical importance moderate the effect...
  92. ncbi Iron biology in immune function, muscle metabolism and neuronal functioning
    J L Beard
    Nutrition Department, College of Human Development, The Pennsylvania State State University, University Park, PA 16802, USA
    J Nutr 131:568S-579S; discussion 580S. 2001
    ....
  93. pmc Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance
    David C Poole
    Departments of Anatomy and Physiology, and Kinesiology, Kansas State University, Manhattan, KS 66506 5802, USA
    Am J Physiol Heart Circ Physiol 302:H1050-63. 2012
    ..g., exercise training and anti-inflammatory, antioxidant strategies, in particular) and hence patient exercise tolerance and quality of life are presented within their appropriate context of the O(2) transport pathway.
  94. ncbi Strength training increases walking tolerance in intermittent claudication patients: randomized trial
    Raphael Mendes Ritti-Dias
    School of Physical Education, University of Pernambuco, Pernambuco, Brazil
    J Vasc Surg 51:89-95. 2010
    ..To analyze the effects of strength training (ST) in walking capacity in patients with intermittent claudication (IC) compared with walking training (WT) effects...
  95. ncbi Granulocyte colony-stimulating factor-induced blood stem cell mobilisation in patients with chronic heart failure--Feasibility, safety and effects on exercise tolerance and cardiac function
    Andreas Hüttmann
    Klinik für Hämatologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Basic Res Cardiol 101:78-86. 2006
    ..Sequential administration of G-CSF is feasible and possibly effective in improving physical performance in patients with chronic heart failure. Patients with ICM may be at risk of increased angina and arrhythmias...
  96. ncbi Progressive resistance exercise improves muscle strength and may improve elements of performance of daily activities for people with COPD: a systematic review
    Simone D O'Shea
    School of Community Health, Charles Sturt University, Albury, NSW, Australia
    Chest 136:1269-83. 2009
    Skeletal muscle weakness and its impact on exercise tolerance in many people with COPD provide a rationale for the intervention of progressive resistance exercise during pulmonary rehabilitation...
  97. ncbi Health-related quality of life and exercise tolerance in recipients of heart transplants and left ventricular assist devices: a prospective, comparative study
    Christiane Kugler
    Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    J Heart Lung Transplant 30:204-10. 2011
    The aim of this study was to evaluate and compare health-related quality of life (HRQoL) and physical exercise tolerance in patients after heart transplantation (HTx) or implantation of a left ventricular assist device (LVAD).
  98. pmc The impact of obesity on walking and cycling performance and response to pulmonary rehabilitation in COPD
    Francesco Sava
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    BMC Pulm Med 10:55. 2010
    We examined the influence of overweight and obesity on pulmonary function, exercise tolerance, quality of life and response to pulmonary rehabilitation in COPD.
  99. ncbi Results of an 8-week, outpatient pulmonary rehabilitation program on patients with and without chronic obstructive pulmonary disease
    Gregory Ferreira
    Division of Pulmonary and Critical Care Medicine, Winthrop University Hospital, State University of New York at Stony Brook, Mineola, USA
    J Cardiopulm Rehabil 26:54-60. 2006
    ..To determine whether there is any difference in the effect of pulmonary rehabilitation (PR) on outcomes in patients with and without chronic obstructive pulmonary disease (COPD)...
  100. pmc An intervention to promote physical activity and self-management in people with stable chronic heart failure The Home-Heart-Walk study: study protocol for a randomized controlled trial
    Hui Y Du
    Curtin Health Innovation Research Institute, Curtin University, Sydney, Chippendale, Australia
    Trials 12:63. 2011
    ..The aim of the Home-Heart-Walk program is to promote adherence to physical activity recommendations and improving self-management in people with CHF...
  101. ncbi Effects of alagebrium, an advanced glycation endproduct breaker, on exercise tolerance and cardiac function in patients with chronic heart failure
    Jasper W L Hartog
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB, Groningen, The Netherlands
    Eur J Heart Fail 13:899-908. 2011
    ..Our aim was to conduct a prospective, randomized, double-blind, placebo-controlled study to examine the effects of the AGE-breaker alagebrium on exercise capacity and cardiac function in patients with HF...

Research Grants66

  1. Use of Phosphodiesterase Inhibitors to Evaluate the Pathobiology of CF
    JENNIFER L TAYLOR-COUSAR; Fiscal Year: 2013
    ..clinical evidence suggests the potential for improvement in both subjective and objective measurements of exercise tolerance in patients with severe CF lung disease and pulmonary vascular disease who are treated with sildenafil...
  2. Planning a Multicenter Trial of PDE5A Inhibition for Duchenne Muscular Dystrophy
    Ronald G Victor; Fiscal Year: 2012
    ..if the drug tadalafil (Cialis), which has bee shown to improve blood flow and muscle fatigue in mice with muscular dystrophy, could be the first ever treatment to improve exercise tolerance in boys with Duchenne muscular dystrophy.
  3. Neurovascular Dysfunction and Oxidative Stress in Renal Failure
    Jeanie Park; Fiscal Year: 2013
    ..We hypothesize that BH4 may be a novel therapeutic agent with potential to impact exercise tolerance, as well as CV morbidity and mortality in patients with CRF...
  4. Reduced contractile reserve: a therapeutic target in heart failure with normal EF
    Nancy K Sweitzer; Fiscal Year: 2012
    ..during periods of increased physiologic stress, despite the consistent clinical presentation of impaired exercise tolerance with few symptoms at rest...
  5. Caring for Those Who Share: Mitigating Iron Deficiency in Regular Blood Donors
    Alan E Mast; Fiscal Year: 2013
    ..deficiency even in the absence of anemia is associated with adverse effects including fatigue and decreased exercise tolerance, as well as neurological symptoms such as decreased cognitive function, pica and restless leg syndrome...
  6. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2013
    ..failure (CHF) difficulty to breathe, and premature fatigue are the main symptoms limiting the patient's exercise tolerance, and ability to perform activities of daily life...
  7. The conditional GPR30 knockout mouse: a model of female-specific cardiac aging
    Leanne Groban; Fiscal Year: 2013
    ..the absence of cardiac GPR30, impairments in myocardial relaxation, left ventricular chamber compliance, exercise tolerance and left ventricular remodeling are accelerated compared to age-matched GPR30-intact littermates exposed to ..
  8. Respiratory Muscle Weakness in Chronic Inflammation
    Francisco H Andrade; Fiscal Year: 2013
    ..This promotes the debilitating sensation of breathlessness, decreases exercise tolerance, and can lead to respiratory failure...
  9. LONG-TERM OXYGEN TREATMENT TRIAL (LOTT) PHARMACOGENOMICS ANCILLARY STUDY
    Craig P Hersh; Fiscal Year: 2013
    ..oxygen and that inter-individual variation in these oxygen-responsive genes will predict change in exercise tolerance and disease-specific quality of life (QoL) in COPD patients treated with long-term oxygen therapy...
  10. The Efficacy of Pranayama in COPD
    David A Kaminsky; Fiscal Year: 2013
    ..Pulmonary rehabilitation is very effective at reducing dyspnea and improving exercise tolerance, but it is not widely available to patients...
  11. Tai Chi after Pulmonary Rehabilitation in Patients with COPD: A Randomized Trial
    Gloria Y Yeh; Fiscal Year: 2013
    ..It may be particularly suited to deconditioned individuals with COPD who suffer from limited exercise tolerance and dyspnea...
  12. Myostatin Regulation of Skeletal Muscle Energy Metabolism
    SUZANNE PORSZASZ-REISZ; Fiscal Year: 2013
    ..physical performance using exercise test model: Outcomes will include: force-velocity relationship, maximal exercise tolerance as measured by VO2max, maximal running speed and the endurance will be characterized by the running speed- ..
  13. Effectiveness of an Automated Walking Program Targeting Veterans with COPD
    Caroline R Richardson; Fiscal Year: 2013
    ..Limitations in daily activities due to reduced exercise tolerance along with frequent hospitalizations for COPD exacerbations contribute to poor quality of life and increased ..
  14. The Overlap Syndrome of COPD and OSA: Determinants of Health Status and Outcomes
    Theodore A Omachi; Fiscal Year: 2012
    ..Omachi will investigate the extent to which OSA contributes to poor health status, including reduced exercise tolerance and poor health-related quality of life, in COPD patients...
  15. Mechanotransduction Approach to Improve Bone Quality in Osteogenesis Imperfecta
    Charlotte L Phillips; Fiscal Year: 2012
    ..In a single study OI children were found to have reduced muscle strength and decreased exercise tolerance relative to healthy age-matched children...
  16. Clinical and Autonomic Effects of Mind-Body Exercise in COPD
    Gloria Y Yeh; Fiscal Year: 2013
    ..It may be particularly suited to deconditioned individuals with COPD, who suffer from limited exercise tolerance and shortness of breath on exertion, and it integrates multiple components relevant to COPD management, ..
  17. Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD
    Jason David Allen; Fiscal Year: 2013
    ..areas of ischemia and (B) chronically increase vessel growth to these ischemic areas would allow for greater exercise tolerance and compliance and facilitate greater improvements in function and quality of life...
  18. Sidenafil Impacts Exercise Performance in Adolescent Survivors of the Fontan
    Robert E Shaddy; Fiscal Year: 2013
    ..hearts, but results in significant symptoms with aging which are reflected in a steadily decreasing exercise tolerance. This study will test if the long term use of sidenafil, which improves exercise in these children with ..
  19. Heart and Skeletal Muscle Metabolism, Energetics and Function in Barth Syndrome
    William Todd Cade; Fiscal Year: 2013
    ..the relationship between skeletal muscle and heart nutrient metabolism, energy production and function (exercise tolerance and heart function)...
  20. Impact of Blood Viscosity on Oxygen Delivery in humans with Sickle Cell Anemia
    THOMAS DUANE COATES; Fiscal Year: 2011
    ..cerebral oxygen content, nighttime hypoxia and autonomic function improve in parallel with improvement in exercise tolerance and pain-free days after dietary supplementation with glutamine...
  21. RODENT PHENOTYPING CORE &OTHER TECHNICAL CORES
    RALPH VICTOR SHOHET; Fiscal Year: 2011
    ..Activity measurements include determinations of metabolism, physical activity, and exercise tolerance. As surgical procedures have been miniaturized for the mouse, investigators have added a range of ..
  22. Biventricular Pacing in Heart Failure
    SAMIR FAWZI SABA; Fiscal Year: 2010
    ..diuretics can extract benefits from BIV pacing in the form of improved maximum oxygen consumption, exercise tolerance, and quality of life, as well as reduced incidence of ventricular arrhythmias...
  23. Effect of fat loss on functional and cardiovascular benefits of aerobic exercise
    Barbara J Nicklas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aging is associated with declines in aerobic capacity, exercise tolerance, and functional endurance that lead to physical disability...
  24. Cardiac and Skeletal Muscle Metabolism and Proteolysis in Heart Failure
    P Christian Schulze; Fiscal Year: 2013
    ..molecular biochemistry, metabolism, and in vivo physiology as applied to derangements of metabolism and exercise tolerance in patients with chronic heart failure. Drs...
  25. Skeletal Muscle Basis for Improved Exercise Endurance in AC5 KO
    Stephen F Vatner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Improving exercise tolerance, one of the major goals of physicians treating patients with cardiovascular disease, can be achieved either by improving cardiac output and blood flow to skeletal muscle, ..
  26. SS peptides: improve mitochondrial and skeletal muscle function with age
    David J Marcinek; Fiscal Year: 2013
    ..hypothesis that reversing mitochondrial dysfunction with SS-31 treatment will reduce sarcopenia and improve exercise tolerance in aged mice...
  27. A percutaneous cardiac implant to treat mitral valve regurgitation
    Michael Lesh; Fiscal Year: 2013
    ..Untreated MR can be debilitating, leading to poor exercise tolerance, shortness of breath, heart failure, and death. Of the 4 million U.S...
  28. Treatment of Skeletal Muscle Dysfunction in ICU Patients
    Gerald S Supinski; Fiscal Year: 2013
    ..reduce the need for mechanical ventilation, shorten hospital stay, improve mortality, and increase exercise tolerance in this patient population...
  29. AC5 Inhibitor for Obesity
    Dorothy E Vatner; Fiscal Year: 2010
    ..The goal of this proposal is to develop a drug that will be therapeutic for obesity and diabetes and improve exercise tolerance. Obesity, diabetes and exercise are inextricably linked such that an agent that improves exercise tolerance ..
  30. Respiratory muscle work and oxidative stress in COPD: impact on leg blood flow an
    Markus Amann; Fiscal Year: 2011
    ..The proposed research will examine novel mechanisms that might contribute to this severe limitation in exercise tolerance and also determine how exercise tolerance might be improved...
  31. Physical Activity in Women with Infants
    CHERYL LYNN ALBRIGHT; Fiscal Year: 2010
    ..b>Exercise tolerance, measured via the 6-minute walk test, is a secondary outcome...
  32. Epsilon-sarcoglycan in LGMD Type 2D
    Kevin Campbell; Fiscal Year: 2009
    ..In addition, we found that this treatment also improves exercise tolerance and reduces exercised-induced muscle edema in our dystrophic mice...
  33. EXERCISE INTOLERANCE IN ELDERLY DIASTOLIC HEART FAILURE
    Dalane W Kitzman; Fiscal Year: 2013
    ..study of spironolactone in 10 elderly patients with isolated DHF there were significant improvements in exercise tolerance, quality of life, and LV diastolic stiffness...
  34. Comprehensive Lab Animal Monitor System (CLAMS) for Rodent Metabolism and Behavio
    Gabriele V Ronnett; Fiscal Year: 2010
    ..assess whole animal physiology, including food intake, energy expenditure, the relative use of fuel sources, exercise tolerance, and activity...
  35. The Microcirculation in Claudication and Exercise Rehabilitation
    Emile R Mohler; Fiscal Year: 2013
    ..Aim-1)To determine in a group of patients with moderate PAD, the relationship between claudication limited exercise tolerance (Peak Walking Time-PWT) and microvascular blood flow...
  36. Work of Breathing and Oxidative Stress in COPD: Impact on Blood Flow and Fatigue
    Markus Amann; Fiscal Year: 2013
    ..The proposed research will examine novel mechanisms that might contribute to this severe limitation in exercise tolerance and also determine how exercise tolerance might be improved...
  37. Cardiovascular Regenerative Medicine
    DOUGLAS EUGENE VAUGHAN; Fiscal Year: 2013
    ..refractory ischemia: patients with intractable angina had significant reductions in chest pain and improved exercise tolerance, while patients with critical limb ischemia had reduced amputation rates...
  38. United State Renal Data System [unreadable] Quality of Life/Rehabilitation Special Study Ctr
    Nancy G Kutner; Fiscal Year: 2009
    ..In addition, persons with ESRD have very low measures of exercise tolerance and general activity levels.
  39. United State Renal Data System [unreadable] Quality of Life/Rehabilitation Special Study Ctr
    Nancy Kutner; Fiscal Year: 2013
    ..In addition, persons with ESRD have very low measures of exercise tolerance and general activity levels.
  40. United State Renal Data System [unreadable] Quality of Life/Rehabilitation Special Study Ctr
    Nancy Kutner; Fiscal Year: 2012
    ..In addition, persons with ESRD have very low measures of exercise tolerance and general activity levels.
  41. ASICs as metabolic sensors in muscle afferents
    Christopher J Benson; Fiscal Year: 2013
    ..to this high sympathetic tone, and alterations of muscle reflexes are believed to contribute to the poor exercise tolerance of patients with heart failure...
  42. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2010
    ..failure (CHF) difficulty to breathe, and premature fatigue are the main symptoms limiting the patient's exercise tolerance, and ability to perform activities of daily life...
  43. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
    ..that display hypercholesterolemia, reduced endothelial function, limited exercise vasodilation, and blunted exercise tolerance. To study these issues in humans we will address the following specific aims...
  44. SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial)
    DOUGLAS LOWELL MANN; Fiscal Year: 2013
    ..3. Implement a HF-specific curriculum: a) weekly CV seminars;b) quarterly HF lecture series;c) yearly HF symposium;d) HF Visiting Professorship;and e) optional external rotations. ..
  45. HEART RATE RECOVERY AND MORTALITY
    Michael Lauer; Fiscal Year: 2002
    ..Data from exercise tolerance tests of over 40,000 patients studied at the Cleveland Clinic Foundation between 1990 and 1999 will be ..
  46. RENAL BLOOD FLOW DURING EXERCISE IN HEART FAILURE
    Holly Middlekauff; Fiscal Year: 2000
    ..The hallmark of congestive heart failure is decreased exercise tolerance, often accompanied by volume overload...
  47. Maximizing Beneficial Exercise Effects in Fibromyalgia.
    Kim Jones; Fiscal Year: 2005
    ..A negative cycle of de-conditioning occurs in FM in large part due to exercise-induced pain that limits exercise tolerance. Dysfunction of the hypothalamic-somatotropic axis, specifically growth hormone (GH)/insulin-like growth ..
  48. Cardiac Autonomic Regulation Enhancement Through Exercise (CARE-E) Trial
    EVA SERBER; Fiscal Year: 2009
    ..The exercise intervention will be personalized according to each participant's exercise tolerance and ICD programmed settings (e.g...
  49. Pathogenesis of Exercise Pressor Reflex Dysfunction in Hypertension
    ANNA LEAL; Fiscal Year: 2009
    ..This knowledge may lead to novel treatments that could potentially increase exercise tolerance in hypertensive patients and reduce the risks associated with exercise in hypertension allowing affected ..
  50. PHYSIOLOGIC BENEFITS OF BIVENTRICULAR PACING IN CHF
    Mohamed Hamdan; Fiscal Year: 2002
    ..Based on these studies, the effect of long term BV pacing on exercise tolerance and quality of life are being assessed in large prospective trials...
  51. CARDIAC PROCEDURE USE: A PROSPECTIVE COHORT STUDY
    Paula Johnson; Fiscal Year: 1999
    ..study will prospectively assess the appropriateness and necessity of cardiac procedures, namely the use of exercise tolerance tests (ETT), coronary angiography, coronary artery bypass graft surgery (CABG), and percutaneous ..
  52. EXERCISE INTOLERANCE IN CONGESTIVE HEART FAILURE
    JOHN MINOTTI; Fiscal Year: 1993
    ..fatiguability and that the resulting decreased muscle endurance correlates closely with impairment of exercise tolerance. The aims of the present proposal are: (1) to determine whether the mechanism of muscle fatigue is impaired ..
  53. AGING AND FUNCTIONAL OUTCOME AFTER SURGERY FOR SDM
    Neil Oldridge; Fiscal Year: 1990
    ..originally developed for other populations, to measure functional status (physical activity patterns, exercise tolerance and quality of life) before and after surgery for SDM in patients 65 years and older, and to correlate these ..
  54. CATECHOLAMINE METABOLISM AND THE HEART
    FLOYD ATKINS; Fiscal Year: 1980
    ..in the treatment of angina pectoris and has been shown to decrease the number of attacks while increasing exercise tolerance. Propranolol exerts its effect by attenuating the effect of cardiac sympathetic simulation, thus reducing ..
  55. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2007
    ..activities of daily living, use more hours of oxygen per day, have better retention of muscle mass and exercise tolerance, have fewer exacerbations and lower medical resource utilization and, ultimately, have superior survival...
  56. Effects of EECP on Arterial Function
    RANDY BRAITH; Fiscal Year: 2006
    ..EECP is efficacious in decreasing angina episodes, nitrate usage, and hospitalizations, and increasing exercise tolerance and quality of life scores...
  57. ELECTROCHEMICAL OXYGEN CONCENTRATOR FOR HOME THERAPY
    BRADLEY FIEBIG; Fiscal Year: 2004
    ..The aims of portable oxygen are to increase exercise tolerance, reduce exercise dyspnea, improve quality of life, and extend the daily hours of LTOT...
  58. R21 PROJECT--EFFICACY OF OSTEOPATHIC MANIPULATION IN COP
    DONALD NOLL; Fiscal Year: 2001
    ..measured by maximum chest wall expansion and reduction; and other clinical measures such as quality of life, exercise tolerance, and dyspnea...
  59. Myoglobin as an indicator of hpoxia tolerance
    STEPHEN KINSEY; Fiscal Year: 2006
    ..A mouse model of inherited hypoxic exercise tolerance (HET) will be used in which 2 inbred strains of mice and their F1 hybrid have dramatically different ..
  60. Age-related changes in the mechanisms of sympathetic neurotransmission in female
    HEIDI KLUESS; Fiscal Year: 2009
    ..potential to impact the management of age-related decline in blood flow in females and ultimately improve exercise tolerance and blood pressure management...
  61. RANDOMIZED TRIAL OF REHABILITATION IN COPD
    Robert Kaplan; Fiscal Year: 1992
    ..The physiological measures included: pulmonary function tests, maximum exercise tolerance with measures of expired and arterial blood gases, and endurance exercise performance...
  62. Hyperglycemia, Frailty and Disability in Older Women
    Caroline Blaum; Fiscal Year: 2006
    ..of hyperglycemia with characteristics defining frailty (weight loss, weakness, slowness, exhaustion, low exercise tolerance) and the frailty syndrome itself, to determine if hyperglycemia at baseline or its change over time predicts ..
  63. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2004
    ..and parallel casual pathways to physical disability: one caused by diseases that affect mobility and exercise tolerance, and the second caused by decrements in cognition...
  64. NURSE-GUIDED EXERCISE PROTOCOL FOR MINORITY WOMEN
    Colleen Keller; Fiscal Year: 2000
    ..women on blood lipids, fat cell size and function, LDL particle size, body fatness and fat distribution, and exercise tolerance. 2: Determine the effects of low and moderate intensity of exercise on exercise maintenance in sedentary, ..
  65. Aging, Chronic Disease and Skeletal Muscle Perfusion
    Timothy Musch; Fiscal Year: 2002
    DESCRIPTION (Applicant's abstract): Physical exercise tolerance declines with advancing age and chronic diseases (e.g., chronic heart failure (CHF)) prevalent in the aging community...
  66. DNA POLYMORPHISMS IN THE MYOSTATIN GENE IN SARCOPENIA
    Jeremy Walston; Fiscal Year: 1999
    Sarcopenia or age-related loss of lean body mass contributes to functional decline, decreased exercise tolerance, falls, frailty, and metabolic changes in the elderly...