physical endurance

Summary

Summary: The time span between the beginning of physical activity by an individual and the termination because of exhaustion.

Top Publications

  1. ncbi Acute cardiac effects of marathon running
    Justin E Trivax
    Department of Cardiovascular Medicine, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48073, USA
    J Appl Physiol (1985) 108:1148-53. 2010
  2. ncbi Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis
    M Doherty
    Division of Sport and Exercise Science, University of Luton, Luton, Beds LU1 3JU, UK
    Scand J Med Sci Sports 15:69-78. 2005
  3. ncbi Comparison of cardioprotective benefits of vigorous versus moderate intensity aerobic exercise
    David P Swain
    Department of Exercise Science, Old Dominion University, Norfolk, Virginia, USA
    Am J Cardiol 97:141-7. 2006
  4. ncbi Neuromuscular adaptations during concurrent strength and endurance training versus strength training
    K HAkkinen
    Neuromuscular Research Center, University of Jyvaskyla, P O Box 35, 40014, Jyvaskyla, Finland
    Eur J Appl Physiol 89:42-52. 2003
  5. ncbi Effects of androgenic-anabolic steroids in athletes
    Fred Hartgens
    Department of Surgery, Outpatient Clinic Sports Medicine, University Hospital Maastricht, and Sports Medicine Center Maastricht, Maastricht, The Netherlands
    Sports Med 34:513-54. 2004
  6. ncbi Endurance running and the evolution of Homo
    Dennis M Bramble
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Nature 432:345-52. 2004
  7. ncbi Reliability of time-to-exhaustion versus time-trial running tests in runners
    Paul B Laursen
    School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
    Med Sci Sports Exerc 39:1374-9. 2007
  8. ncbi Can neuromuscular fatigue explain running strategies and performance in ultra-marathons?: the flush model
    Guillaume Y Millet
    Universite de Lyon, and Laboratoire dePhysiologie de l Exercice EA 4338, Médecine du Sport Myologie, Hopital Bellevue, F 42023, Saint Etienne, France
    Sports Med 41:489-506. 2011
  9. ncbi The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition
    Iain P Kendrick
    University of Chichester, College Lane, Chichester, West Sussex PO196PE, UK
    Amino Acids 34:547-54. 2008
  10. ncbi The scientific basis for high-intensity interval training: optimising training programmes and maximising performance in highly trained endurance athletes
    Paul B Laursen
    School of Human Movement Studies, University of Queensland, Brisbane, Australia
    Sports Med 32:53-73. 2002

Research Grants

  1. Effect of leg strengthening exercise after hip fracture
    KATHLEEN MANGIONE; Fiscal Year: 2004
  2. MOLECULAR GENETICS OF THERMOGENESIS
    MARTIN ELLIOT YOUNG; Fiscal Year: 2013
  3. ROCK and Obesity
    JAMES KUANG JAN LIAO; Fiscal Year: 2013
  4. Exercise Versus Cognitive Interventions for Elders at Risk for Dementia
    David Loewenstein; Fiscal Year: 2010
  5. Frequency of aerobic/resistance training in older women
    Gary Hunter; Fiscal Year: 2009
  6. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
  7. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2008
  8. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
  9. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
  10. Exercise Substrate Utilization:The Crossover Concept
    George Brooks; Fiscal Year: 2006

Detail Information

Publications282 found, 100 shown here

  1. ncbi Acute cardiac effects of marathon running
    Justin E Trivax
    Department of Cardiovascular Medicine, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48073, USA
    J Appl Physiol (1985) 108:1148-53. 2010
    ....
  2. ncbi Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis
    M Doherty
    Division of Sport and Exercise Science, University of Luton, Luton, Beds LU1 3JU, UK
    Scand J Med Sci Sports 15:69-78. 2005
    ..The results demonstrate that caffeine reduces RPE during exercise and this may partly explain the subsequent ergogenic effects of caffeine on performance...
  3. ncbi Comparison of cardioprotective benefits of vigorous versus moderate intensity aerobic exercise
    David P Swain
    Department of Exercise Science, Old Dominion University, Norfolk, Virginia, USA
    Am J Cardiol 97:141-7. 2006
    ..In conclusion, if the total energy expenditure of exercise is held constant, exercise performed at a vigorous intensity appears to convey greater cardioprotective benefits than exercise of a moderate intensity...
  4. ncbi Neuromuscular adaptations during concurrent strength and endurance training versus strength training
    K HAkkinen
    Neuromuscular Research Center, University of Jyvaskyla, P O Box 35, 40014, Jyvaskyla, Finland
    Eur J Appl Physiol 89:42-52. 2003
    ....
  5. ncbi Effects of androgenic-anabolic steroids in athletes
    Fred Hartgens
    Department of Surgery, Outpatient Clinic Sports Medicine, University Hospital Maastricht, and Sports Medicine Center Maastricht, Maastricht, The Netherlands
    Sports Med 34:513-54. 2004
    ..AAS-induced increment of muscle tissue can be attributed to hypertrophy and the formation of new muscle fibres, in which key roles are played by satellite cell number and ultrastructure, androgen receptors and myonuclei...
  6. ncbi Endurance running and the evolution of Homo
    Dennis M Bramble
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Nature 432:345-52. 2004
    ..The fossil evidence of these features suggests that endurance running is a derived capability of the genus Homo, originating about 2 million years ago, and may have been instrumental in the evolution of the human body form...
  7. ncbi Reliability of time-to-exhaustion versus time-trial running tests in runners
    Paul B Laursen
    School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
    Med Sci Sports Exerc 39:1374-9. 2007
    ..Both time-to-exhaustion (TTE) and time-trial (TT) exercise tests are commonly used to assess exercise performance, but no study has directly examined the reliability of comparable tests in the same subjects...
  8. ncbi Can neuromuscular fatigue explain running strategies and performance in ultra-marathons?: the flush model
    Guillaume Y Millet
    Universite de Lyon, and Laboratoire dePhysiologie de l Exercice EA 4338, Médecine du Sport Myologie, Hopital Bellevue, F 42023, Saint Etienne, France
    Sports Med 41:489-506. 2011
    ..This holistic model also explains how environmental conditions, sleep deprivation/mental fatigue, pain-killers or psychostimulants, cognitive or nutritional strategies may affect ultra-running performance...
  9. ncbi The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition
    Iain P Kendrick
    University of Chichester, College Lane, Chichester, West Sussex PO196PE, UK
    Amino Acids 34:547-54. 2008
    ..There was no significant effect of beta-ala supplementation on any of the exercise parameters measured, mass or % body fat. In conclusion, 10 weeks of resistance training alone did not change M-[Carn]...
  10. ncbi The scientific basis for high-intensity interval training: optimising training programmes and maximising performance in highly trained endurance athletes
    Paul B Laursen
    School of Human Movement Studies, University of Queensland, Brisbane, Australia
    Sports Med 32:53-73. 2002
    ....
  11. ncbi American College of Sports Medicine position stand. Exertional heat illness during training and competition
    Lawrence E Armstrong
    Med Sci Sports Exerc 39:556-72. 2007
    ..Muscle cramping usually responds to rest and replacement of fluid and salt (sodium). Prevention strategies are essential to reducing the incidence of EHS, heat exhaustion, and exercise associated muscle cramping...
  12. pmc The Western States 100-Mile Endurance Run: participation and performance trends
    Martin D Hoffman
    Department of Physical Medicine and Rehabilitation, Department of Veterans Affairs, Northern California Health Care System, and University of California Davis Medical Center, Sacramento, CA, USA
    Med Sci Sports Exerc 41:2191-8. 2009
    ..Examine changes in demographics of participants and performance trends at the Western States 100-Mile Endurance Run (WSER) since its inception in 1974...
  13. ncbi Impact of weather on marathon-running performance
    Matthew R Ely
    U S Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
    Med Sci Sports Exerc 39:487-93. 2007
    ..Marathon running performance slows in warm weather conditions, but the quantitative impact of weather has not been established...
  14. ncbi Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans
    Kirsten A Burgomaster
    Exercise Metabolism Research Group, Dept of Kinesiology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    J Appl Physiol 98:1985-90. 2005
    ..We conclude that short sprint interval training (approximately 15 min of intense exercise over 2 wk) increased muscle oxidative potential and doubled endurance capacity during intense aerobic cycling in recreationally active individuals...
  15. ncbi Role of beta-alanine supplementation on muscle carnosine and exercise performance
    Guilherme Giannini Artioli
    Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, Brazil
    Med Sci Sports Exerc 42:1162-73. 2010
    ..No important side effect was related to the use of this amino acid so far. In conclusion, beta-alanine supplementation seems to be a safe nutritional strategy capable of improving high-intensity anaerobic performance...
  16. pmc Endurance exercise performance: the physiology of champions
    Michael J Joyner
    Departments of Anaesthesiology and Physiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 586:35-44. 2008
    ..Therefore, the performance of elite athletes is likely to defy the types of easy explanations sought by scientific reductionism and remain an important puzzle for those interested in physiological integration well into the future...
  17. ncbi Influence of mouth rinsing a carbohydrate solution on 1-h running performance
    Ian Rollo
    School of Sport and Exercise Sciences, Loughborough University, Loughborough, Leicestershire, United Kingdom
    Med Sci Sports Exerc 42:798-804. 2010
    ..A second study determined whether mouth rinsing a CHO-E solution altered the blood glucose and plasma insulin concentrations at rest...
  18. ncbi Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis
    Konstantinos Margonis
    Department of Physical Education and Sports Science, Democritus University of Thrace, Komotini 69100, and Department of Internal Medicine, Henry Dunant Hospital, Athens, Greece
    Free Radic Biol Med 43:901-10. 2007
    ..In conclusion, overtraining induces a marked response of oxidative stress biomarkers which, in some cases, was proportional to training load, suggesting that they may serve as a tool for overtraining diagnosis...
  19. ncbi Effect of resistance training regimens on treadmill running and neuromuscular performance in recreational endurance runners
    Jussi Mikkola
    KIHU Research Institute for Olympic Sports, Jyvaskyla, Finland
    J Sports Sci 29:1359-71. 2011
    ..Thus, endurance runners should include heavy resistance training in their training programmes to enhance endurance performance, such as improving sprinting ability at the end of a race...
  20. ncbi Expression of perilipins in human skeletal muscle in vitro and in vivo in relation to diet, exercise and energy balance
    I M F Gjelstad
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    Arch Physiol Biochem 118:22-30. 2012
    ..In conclusion, all perilipins mRNAs were expressed in human skeletal muscle. Diet as well as endurance exercise modulated the expression of perilipins...
  21. pmc Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans
    Markus Amann
    University of Wisconsin Medical School, John Rankin Laboratory of Pulmonary Medicine, Madison, WI, USA
    J Physiol 581:389-403. 2007
    ....
  22. ncbi Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle
    Masataka Suwa
    Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816 8580, Japan
    Metabolism 57:986-98. 2008
    ....
  23. ncbi Chocolate milk and endurance exercise recovery: protein balance, glycogen, and performance
    William R Lunn
    Exercise Science Department, Southern Connecticut State University, Moore Field House, Room 169, New Haven, CT 06515, USA
    Med Sci Sports Exerc 44:682-91. 2012
    ..This study examined effects of fat-free chocolate milk (MILK) consumption on kinetic and cellular markers of protein turnover, muscle glycogen, and performance during recovery from endurance exercise...
  24. ncbi Caffeine improves supramaximal cycling but not the rate of anaerobic energy release
    Michael J Simmonds
    School of Physiotherapy and Exercise Science, Gold Coast Campus, Griffith University, Southport, QLD 4215, Australia
    Eur J Appl Physiol 109:287-95. 2010
    ..Considering caffeine ingestion did not change VO2 kinetics or isotime AO(2) deficit, increases in absolute AO(2) deficit may be a consequence of prolonged TE, rather than causal...
  25. ncbi Postexercise carbohydrate-protein supplementation improves subsequent exercise performance and intracellular signaling for protein synthesis
    Lisa Ferguson-Stegall
    Exercise Physiology and Metabolism Laboratory, Department of Kinesiology, University of Texas at Austin, Austin, Texas, USA
    J Strength Cond Res 25:1210-24. 2011
    ..7 vs. 69.2 ± 5.5%, p ≤ 0.05). These results indicate that postexercise CM supplementation can improve subsequent exercise performance and provide a greater intracellular signaling stimulus for PRO synthesis compared to CHO and placebo...
  26. ncbi Serum basal hormone concentrations, nutrition and physical fitness during strength and/or endurance training in 39-64-year-old women
    E Sillanpää
    University of Jyvaskyla, Department of Biology of Physical Activity, Jyvaskyla, Finland
    Int J Sports Med 31:110-7. 2010
    ....
  27. ncbi Caffeine withdrawal and high-intensity endurance cycling performance
    Christopher Irwin
    School of Public Health, Griffith University, Gold Coast, Queensland, Australia
    J Sports Sci 29:509-15. 2011
    ..A 3 mg · kg(-1) dose of caffeine significantly improves exercise performance irrespective of whether a 4-day withdrawal period is imposed on habitual caffeine users...
  28. ncbi ACTN3 R577X polymorphism and Israeli top-level athletes
    N Eynon
    The Zinman College of Physical Education and Sports Sciences at the Wingate Institute, Netanya, Israel
    Int J Sports Med 30:695-8. 2009
    ..We conclude that the ACTN3 R allele is associated with top-level sprint performance and the X allele and XX genotypes may not be critical but rather additive to endurance performance...
  29. ncbi Hydration and muscular performance: does fluid balance affect strength, power and high-intensity endurance?
    Daniel A Judelson
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, Connecticut, USA
    Sports Med 37:907-21. 2007
    ....
  30. ncbi Effect of different protocols of caffeine intake on metabolism and endurance performance
    Gregory R Cox
    Sports Science and Sports Medicine, Australian Institute of Sport, Belconnen, Australian Capital Territory 2616, Australia
    J Appl Physiol 93:990-9. 2002
    ..5 mg/kg)...
  31. ncbi Physiological and biological factors associated with a 24 h treadmill ultra-marathon performance
    G Y Millet
    Exercise Physiology Laboratory, Jean Monnet University, Saint Etienne, France
    Scand J Med Sci Sports 21:54-61. 2011
    ..The ability to maintain a high %VO(2max) over a 24TR is another factor associated with performance and is mainly related to RE and high mitochondrial oxidative capacity in the vastus lateralis...
  32. ncbi Maximal strength training improves running economy in distance runners
    Oyvind Støren
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Med Sci Sports Exerc 40:1087-92. 2008
    ..Responses in one repetition maximum (1RM) and rate of force development (RFD) in half-squats, maximal oxygen consumption, RE, and time to exhaustion at MAS were examined...
  33. ncbi Six weeks of high-intensity interval training with and without beta-alanine supplementation for improving cardiovascular fitness in women
    Ashley A Walter
    Biophysics Laboratory, Department of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma, USA
    J Strength Cond Res 24:1199-207. 2010
    ..Overall, these results suggested that HIIT may be an effective and time-efficient method of training to improve maximal oxygen uptake...
  34. ncbi Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise
    William W Winder
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Med Sci Sports Exerc 38:1945-9. 2006
    ..These observations lend credence to the hypothesis that AMPK activation induced by muscle contraction is responsible in part for adaptations to endurance exercise training...
  35. pmc Repeatability of exercise behaviors in mice
    Amy M Knab
    Department of Kinesiology, University of North Carolina, Charlotte, United States
    Physiol Behav 98:433-40. 2009
    ..This study assessed the repeatability of a commonly used maximal exercise endurance treadmill test as well as voluntary physical activity measured by wheel running in mice...
  36. ncbi Acute changes in endocrine and fluid balance markers during high-intensity, steady-state, and prolonged endurance running: unexpected increases in oxytocin and brain natriuretic peptide during exercise
    Tamara Hew-Butler
    University of Cape Town, Cape Town, 7725 South Africa
    Eur J Endocrinol 159:729-37. 2008
    ....
  37. ncbi Hormonal responses to a 160-km race across frozen Alaska
    W J Kraemer
    University of Connecticut, Human Performance Laboratory, Storrs, Connecticut 06269 1110, USA
    Br J Sports Med 42:116-20; discussion 120. 2008
    ..Examining hormonal responses to an extreme 160-km competition across frozen Alaska provides a unique opportunity to study this intense stress...
  38. ncbi Coingestion of protein with carbohydrate during recovery from endurance exercise stimulates skeletal muscle protein synthesis in humans
    Krista R Howarth
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol (1985) 106:1394-402. 2009
    ..However, adding protein or additional CHO to a feeding strategy that provided 1.2 g CHO x kg(-1) x h(-1) did not further enhance glycogen resynthesis during recovery...
  39. pmc Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance
    Markus Amann
    The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Medical School, 4245 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    J Physiol 586:161-73. 2008
    ..35). We suggest that feedback from fatiguing muscle plays an important role in the determination of central motor drive and force output, so that the development of peripheral muscle fatigue is confined to a certain level...
  40. ncbi A 3-min all-out test to determine peak oxygen uptake and the maximal steady state
    Mark Burnley
    Department of Sport and Exercise Science, University of Wales, Aberystwyth, Ceredigion, UK
    Med Sci Sports Exerc 38:1995-2003. 2006
    ..We tested the hypothesis that a 3-min all-out cycling test would provide a measure of peak oxygen uptake (VO2peak) and estimate the maximal steady-state power output...
  41. pmc A signalling role for muscle glycogen in the regulation of pace during prolonged exercise
    H G L Rauch
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Sports Science Institute, Boundary Road, Newlands, Cape Town 7700, South Africa
    Br J Sports Med 39:34-8. 2005
    ..In this study we examined the pacing strategy and the end muscle glycogen contents in eight cyclists, once when they were carbohydrate loaded and once when they were non-loaded...
  42. ncbi Training and performance characteristics among Norwegian international rowers 1970-2001
    A Fiskerstrand
    Norwegian Rowing Federation, Oslo, Norway
    Scand J Med Sci Sports 14:303-10. 2004
    ....
  43. ncbi Analysis of Hawaii ironman performances in elite triathletes from 1981 to 2007
    Romuald Lepers
    INSERM U887, Faculty of Sport Sciences, University of Burgundy, Dijon, France
    Med Sci Sports Exerc 40:1828-34. 2008
    ..To examine the improvement in swimming (3.8 km), cycling (180 km), running (42.2 km), and overall performances at the Hawaii Ironman Triathlon of elite males and females between 1981 and 2007...
  44. ncbi Performance trends in 161-km ultramarathons
    M D Hoffman
    Department of Physical Medicine and Rehabilitation, Department of Veterans Affairs, Northern California Health Care System, University of California Davis Medical Center, Sacramento, California, USA
    Int J Sports Med 31:31-7. 2010
    ....
  45. ncbi Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin (r-HuEPO) treatment
    Philippe Connes
    UPRES EA 2991, Laboratoire Sport Performance Santé, Faculte des Sciences du Sport, Universite Montpellier 1, 34090 Montpellier, France
    Pflugers Arch 447:231-8. 2003
    ..5+/-7.3 vs. 33.4+/-7.9 s). Collectively, our findings suggest that r-HuEPO contributes both to an acceleration of the dynamic response of VO2 to submaximal exercise and to an increase in maximal exercise capacity...
  46. pmc Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans
    Mark Rakobowchuk
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 295:R236-42. 2008
    ..However, alterations in central artery distensibility may require a longer training stimuli and/or greater initial vascular stiffness than observed in this group of healthy subjects...
  47. ncbi Caffeine and anaerobic performance: ergogenic value and mechanisms of action
    J K Davis
    Department of Health and Human Performance, Texas A and M University Commerce, Commerce, Texas, USA
    Sports Med 39:813-32. 2009
    ..The exact mechanisms behind caffeine's action remain to be elucidated...
  48. ncbi Skeletal muscle telomere length in healthy, experienced, endurance runners
    Dale E Rae
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Eur J Appl Physiol 109:323-30. 2010
    ..035). Therefore, since exposure to endurance running may influence minimum TRF length, and by implication, the proliferative potential of the satellite cells, chronic endurance running may be seen as a stressor to skeletal muscle...
  49. ncbi Physiological profiles of elite judo athletes
    Emerson Franchini
    Martial Arts and Combat Sports Research Group, School of Physical Education and Sport, University of So Paulo, So Paulo, Brazil
    Sports Med 41:147-66. 2011
    ..However, further research is needed concerning the differences among the seven weight categories in which judo athletes compete...
  50. ncbi Factors related to successful completion of a 161-km ultramarathon
    Martin D Hoffman
    Department of Physical Medicine and Rehabilitation, Department of Veterans Affairs, Northern California Health Care System, and the University of California Davis Medical Center, Sacramento, CA, USA
    Int J Sports Physiol Perform 6:25-37. 2011
    ..This study surveyed entrants in two of the largest 161-km trail ultramarathon runs in North America to explore demographic characteristics and issues that affected race performance...
  51. ncbi Endurance training enhances BDNF release from the human brain
    Thomas Seifert
    Department of Anesthesia, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 298:R372-7. 2010
    ..4.6 + or - 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health...
  52. pmc Mechanisms for exercise training-induced increases in skeletal muscle blood flow capacity: differences with interval sprint training versus aerobic endurance training
    M H Laughlin
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    J Physiol Pharmacol 59:71-88. 2008
    ..Finally, evidence indicates that ET and IST induce non-uniform changes in smooth muscle and endothelium throughout skeletal muscle arteriolar networks...
  53. pmc Methods, advantages, and limitations of body cooling for exercise performance
    F E Marino
    Human Movement Studies Unit, Charles Sturt University, Bathurst, NSW, Australia
    Br J Sports Med 36:89-94. 2002
    ..However, it seems that precooling is only beneficial for endurance exercise of up to 30-40 minutes rather than intermittent or short duration exercise...
  54. ncbi Prior endurance exercise attenuates growth hormone response to subsequent resistance exercise
    Kazushige Goto
    Institute of Health and Sport Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8574, Japan
    Eur J Appl Physiol 94:333-8. 2005
    ..05). These results indicate that the GH response to resistance exercise is attenuated by prior endurance exercise. This effect might be caused by the increase in blood FFA concentration at the beginning of resistance exercise...
  55. ncbi Skiing across the Greenland icecap: divergent effects on limb muscle adaptations and substrate oxidation
    Jørn W Helge
    Copenhagen Muscle Research Centre, National University Hospital, Denmark
    J Exp Biol 206:1075-83. 2003
    ..Although the number of subjects is limited, these results imply that the adaptation pattern after long-term, prolonged, low-intensity, whole body exercise may vary dramatically among muscles...
  56. ncbi Branched-chain amino acid supplementation and the immune response of long-distance athletes
    Reinaldo A Bassit
    Department of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 18:376-9. 2002
    ..Therefore, we evaluated the effect of branched-chain amino acid supplementation on the immune response of triathletes and long-distance runners...
  57. ncbi Relation of biomarkers and cardiac magnetic resonance imaging after marathon running
    Negareh Mousavi
    Section of Cardiology, Department of Cardiac Sciences, St Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Cardiol 103:1467-72. 2009
    ..The increase in cardiac troponin after marathon running is likely due to the cytosolic release of the biomarker, not to the true breakdown of the myocyte, as confirmed by delayed enhancement CMR imaging...
  58. pmc Effects of a supervised home-based aerobic and progressive resistance training regimen in women infected with human immunodeficiency virus: a randomized trial
    Sara E Dolan
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital, Boston 02114, USA
    Arch Intern Med 166:1225-31. 2006
    ..Women infected with human immunodeficiency virus (HIV) increasingly demonstrate abnormalities in fat distribution and metabolism; however, the effects of a home-based exercise regimen in this group have not been investigated...
  59. ncbi Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers
    M Tarnopolsky
    Department of Neurology and Rehabilitation Medicine and Kinesiology, McMaster University Medical Center, Hamilton, Ontario L8N 3Z5, Canada
    J Appl Physiol (1985) 89:1719-24. 2000
    ..These data support the hypothesis that some of the ergogenic effect of caffeine in endurance exercise performance occurs directly at the skeletal muscle level...
  60. ncbi Effects of long-term training specificity on maximal strength and power of the upper and lower extremities in athletes from different sports
    Mikel Izquierdo
    Centro de Investigacion y Medicina del Deporte, Gobierno de Navarra, C Paulino Caballero 13, 31002 Pamplona Navarra, Spain
    Eur J Appl Physiol 87:264-71. 2002
    ....
  61. ncbi Advantages of smaller body mass during distance running in warm, humid environments
    F E Marino
    Human Movement Studies Unit, Charles Sturt University, Bathurst, NSW, Australia
    Pflugers Arch 441:359-67. 2000
    ..Lighter runners produce and store less heat at the same running speed; hence they can run faster or further before reaching a limiting rectal temperature...
  62. ncbi Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis
    Antonio Ascensao
    Department of Sport Biology, Faculty of Sport Sciences, Univ of Porto, Rua Dr Placido Costa, 91, 4200 450 Porto, Portugal
    Am J Physiol Heart Circ Physiol 289:H722-31. 2005
    ..In addition, endurance training limited the DOX-triggered apoptosis...
  63. ncbi Training principles and issues for ultra-endurance athletes
    Calvin Zaryski
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 2N4, Canada
    Curr Sports Med Rep 4:165-70. 2005
    ..Furthermore, the treatment of soft tissue after training or racing is necessary to control inflammation...
  64. ncbi The effect of carbohydrate mouth rinse on 1-h cycle time trial performance
    James M Carter
    Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    Med Sci Sports Exerc 36:2107-11. 2004
    ..5% of the trial completed. On the other occasion, water (PLA) was rinsed. Subjects were not allowed to swallow either the CHO solution or water, and each mouthful was spat out after a 5-s rinse...
  65. ncbi Effects of intermittent hypoxic training on cycling performance in well-trained athletes
    Belle Roels
    UPRES EA 3759 Multidisciplinary Approach of Doping, 700 avenue Pic St Loup, 34090, Montpellier, France
    Eur J Appl Physiol 101:359-68. 2007
    ..However, IHT has the potential to assist athletes in preparation for competition at altitude...
  66. ncbi Age and gender interactions in ultraendurance performance: insight from the triathlon
    Romuald Lepers
    Faculty of Sport Sciences, University of Burgundy, Dijon, France
    Med Sci Sports Exerc 43:134-9. 2011
    ..8 km), cycling (180 km), and running (42 km) performances as a function of age...
  67. ncbi Postexercise muscle glycogen recovery enhanced with a carbohydrate-protein supplement
    John M Berardi
    Exercise Nutrition Research Laboratory, Faculty of Health Sciences, School of Kinesiology, The University of Western Ontario, Ontario, Canada
    Med Sci Sports Exerc 38:1106-13. 2006
    ....
  68. ncbi Effect of caffeine on sport-specific endurance performance: a systematic review
    Matthew S Ganio
    Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, Connecticut, USA
    J Strength Cond Res 23:315-24. 2009
    ..kg body mass). Abstaining from caffeine at least 7 days before use will give the greatest chance of optimizing the ergogenic effect...
  69. ncbi The influence of carbohydrate and protein ingestion during recovery from prolonged exercise on subsequent endurance performance
    James Betts
    Sport and Exercise Science, University of Bath, Bath, UK
    J Sports Sci 25:1449-60. 2007
    ..In conclusion, increasing the energy content of these recovery solutions extended run time to exhaustion, irrespective of whether the additional energy originated from sucrose or whey protein isolate...
  70. ncbi Muscular adaptations in response to three different resistance-training regimens: specificity of repetition maximum training zones
    Gerson E R Campos
    Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Irvine Hall, rm 430, Athens, OH 45701, USA
    Eur J Appl Physiol 88:50-60. 2002
    ....
  71. ncbi Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Ontario, Canada
    Eur Respir J 23:832-40. 2004
    ..Resultant increases in inspiratory capacity permitted greater expansion of tidal volume and contributed to improvements in both exertional dyspnoea and exercise endurance...
  72. ncbi Strenuous endurance training in humans reduces oxidative stress following exhausting exercise
    H Miyazaki
    Institute of Health and Sport Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8574, Japan
    Eur J Appl Physiol 84:1-6. 2001
    ..production in response to exhausting exercise. Furthermore, this up-regulation in antioxidant defences was accompanied by a reduction in exercise-induced lipid peroxidation in erythrocyte membrane...
  73. ncbi Impact of a competitive marathon race on systemic cytokine and neutrophil responses
    Katsuhiko Suzuki
    Department of Hygiene, Hirosaki University School of Medicine, Aomori, Japan
    Med Sci Sports Exerc 35:348-55. 2003
    ..To investigate whether cytokines and neutrophils mediate exercise-related pathogenesis, we examined their responses and possible association after exhaustive exercise...
  74. ncbi Functional incidental training: a randomized, controlled, crossover trial in Veterans Affairs nursing homes
    Joseph G Ouslander
    Division of Geriatric Medicine and Gerontology, Department of Medicine, and the Center for Health in Aging, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    J Am Geriatr Soc 53:1091-100. 2005
    ..To test the effects of a rehabilitative intervention directed at continence, mobility, endurance, and strength (Functional Incidental Training (FIT)) in older patients in Department of Veterans Affairs (VA) nursing homes...
  75. ncbi Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli
    Andreas N Kavazis
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Heart Circ Physiol 294:H928-35. 2008
    ..Furthermore, these results are consistent with the concept that exercise-induced mitochondrial adaptations contribute to exercise-induced cardioprotection...
  76. ncbi Weight changes, sodium levels, and performance in the South African Ironman Triathlon
    Karen Sharwood
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town and Sports Science Institute of South Africa, South Africa
    Clin J Sport Med 12:391-9. 2002
    ..To establish relationships between body weight changes and serum sodium during and after an Ironman Triathlon, and postrace fluid status and rectal temperature, including the incidence of hyponatremia...
  77. ncbi Effects of a carbohydrate-protein beverage on cycling endurance and muscle damage
    Michael J Saunders
    School of Kinesiology and Recreation Studies, James Madison University, Harrisonburg, VA 22807, USA
    Med Sci Sports Exerc 36:1233-8. 2004
    ..3% and 1.8% concentrations) versus a carbohydrate-only (CHO; 7.3%) beverage...
  78. pmc ACTN3 genotype is associated with human elite athletic performance
    Nan Yang
    Institute for Neuromuscular Research, Children s Hospital at Westmead, Sydney, Australia
    Am J Hum Genet 73:627-31. 2003
    ..The differential effects in sprint and endurance athletes suggests that the R577X polymorphism may have been maintained in the human population by balancing natural selection...
  79. ncbi Effects of prior heavy-intensity exercise on oxygen uptake and muscle deoxygenation kinetics of a subsequent heavy-intensity cycling and knee-extension exercise
    Sarah Margaret Cleland
    Canadian Centre for Activity and Aging, University of Western Ontario, London, Canada
    Appl Physiol Nutr Metab 37:138-48. 2012
    ....
  80. ncbi The PPARGC1A gene Gly482Ser in Polish and Russian athletes
    Agnieszka Maciejewska
    Department of Genetics, University of Szczecin, Szczecin, Poland
    J Sports Sci 30:101-13. 2012
    ..These findings support the hypothesis that the PPARGC1A 482Ser allele may impair aerobic capacity: thus, the Gly482 allele may be considered a beneficial factor for endurance performance...
  81. pmc Effects of exercise training intensity on nocturnal growth hormone secretion in obese adults with the metabolic syndrome
    Brian A Irving
    Department of Human Services, Center for the Study of Complementary and Alternative Therapies, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 94:1979-86. 2009
    ..However, little is known about the effects of endurance training intensity on spontaneous GH release in obese individuals...
  82. ncbi Effect of β-alanine plus sodium bicarbonate on high-intensity cycling capacity
    Craig Sale
    Biomedical, Life and Health Sciences Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK
    Med Sci Sports Exerc 43:1972-8. 2011
    ..We examined the effect of β-alanine supplementation plus sodium bicarbonate on high-intensity cycling capacity...
  83. ncbi Effect of low-dose endurance training on heart rate variability at rest and during an incremental maximal exercise test
    Kaisu Martinmäki
    Department of Biology of Physical Activity, University of Jyvaskyla, P O Box 35 LL, 40014 Jyvaskyla, Finland
    Eur J Appl Physiol 104:541-8. 2008
    ..05-0.01) at absolute submaximal exercise intensities, but not at rest. In conclusion, low-dose endurance training enhanced vagal control during exercise, but did not alter resting vagal HR control...
  84. ncbi Plasma IL-6 concentration during ultra-endurance exercise
    Linnea Wallberg
    Astrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Box 5626, SE 114 86 Stockholm, Sweden
    Eur J Appl Physiol 111:1081-8. 2011
    ....
  85. ncbi Effect of protein-rich feeding on recovery after intense exercise
    David S Rowlands
    Institute of Food, Nutrition, and Human Health, Massey University, Wellington, New Zealand
    Int J Sport Nutr Exerc Metab 17:521-43. 2007
    ..9% (+/-6.9%), suggesting that individual responses to the protein-enriched treatment contributed to the unclear performance outcome. To conclude, protein-enriched recovery feeding had no clear effect on next-day performance...
  86. ncbi Intense training: the key to optimal performance before and during the taper
    I Mujika
    USP Araba Sport Clinic, Vitoria Gasteiz, Basque Country, Spain
    Scand J Med Sci Sports 20:24-31. 2010
    ..A tapering and peaking program before the start of a league format championship or a major tournament should be characterized by high-intensity activities...
  87. ncbi High-intensity interval training: a time-efficient strategy for health promotion?
    Martin J Gibala
    Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Curr Sports Med Rep 6:211-3. 2007
  88. ncbi No gender difference in peak performance in ultra-endurance swimming performance - analysis of the 'Zurich 12-h Swim' from 1996 to 2010
    Evelyn Eichenberger
    Institute of General Practice and for Health Services Research, University of Zurich, Switzerland
    Chin J Physiol 55:346-51. 2012
    ..Further studies are needed to investigate whether females are able to achieve similar or even better performances than males in openwater ultra-swimming events such as 'Channel Swimming'...
  89. ncbi Concurrent strength and endurance training. A review
    M Leveritt
    Centre for Sport and Exercise Science, Waikato Polytechnic, Hamilton, New Zealand
    Sports Med 28:413-27. 1999
    ..Further systematic research is necessary to quantify the inhibitory effects of concurrent training on strength development and to identify different training approaches that may overcome any negative effects of concurrent training...
  90. pmc Master's performance in the New York City Marathon 1983-1999
    P Jokl
    Department of Orthopaedics, Yale University, Yale Physicians Building, 800 Howard Avenue, New Haven, CT 06512, USA
    Br J Sports Med 38:408-12. 2004
    ..Physical activity in older people is believed to slow down the natural aging process through its effects on disuse atrophy...
  91. ncbi The effect of strength and endurance training on gait, balance, fall risk, and health services use in community-living older adults
    D M Buchner
    Department of Health Services, University of Washington, Seattle, USA
    J Gerontol A Biol Sci Med Sci 52:M218-24. 1997
    ..The study tested the effect of strength and endurance training on gait, balance, physical health status, fall risk, and health services use in older adults...
  92. ncbi Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle
    Joachim Nielsen
    Institute of Sports Science and Clinical Biomechanics, Univ of Southern Denmark, Odense, Denmark
    Am J Physiol Endocrinol Metab 298:E706-13. 2010
    ..Thus consideration of cell compartmentation may advance the understanding of the role of lipids in muscle function and type 2 diabetes...
  93. ncbi The effects of different doses of caffeine on endurance cycling time trial performance
    Ben Desbrow
    School of Public Health, Research Centre for Clinical and Community Practice Innovation, Griffith Health Institute, Griffith University, Queensland, Australia
    J Sports Sci 30:115-20. 2012
    ..39). A caffeine dose of 3 mg x kg(-1) body mass appears to improve cycling performance in well-trained and familiarised athletes. Doubling the dose to 6 mg x kg(-1) body mass does not confer any additional improvements in performance...
  94. ncbi Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women
    J R Stout
    Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019 6081, USA
    Amino Acids 32:381-6. 2007
    ..In conclusion, beta-alanine supplementation appears to improve submaximal cycle ergometry performance and TTE in young women, perhaps as a result of an increased buffering capacity due to elevated muscle carnosine concentrations...
  95. ncbi The runner's high: opioidergic mechanisms in the human brain
    Henning Boecker
    Nuklearmedizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munchen, Germany
    Cereb Cortex 18:2523-31. 2008
    ..These findings support the "opioid theory" of the runner's high and suggest region-specific effects in frontolimbic brain areas that are involved in the processing of affective states and mood...
  96. ncbi Effect of an isocaloric carbohydrate-protein-antioxidant drink on cycling performance
    Brett C Romano-Ely
    Department of Kinesiology, James Madison University, Harrisonburg, VA 22807, USA
    Med Sci Sports Exerc 38:1608-16. 2006
    ..Fourteen male cyclists were studied to compare the effect of carbohydrate-protein-antioxidant beverage (CHOPA) to an isocaloric carbohydrate-only (CHO) beverage on time to fatigue and muscle damage...
  97. ncbi Systemic and pulmonary oxidative stress after single-leg exercise in COPD
    Evi M Mercken
    Departments of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Chest 136:1291-300. 2009
    ..Our aim for this study was to disentangle the contribution of muscular vs pulmonary oxidative stress during endurance exercise in patients with COPD...
  98. ncbi Mechanisms underpinning exercise-induced changes in left ventricular function
    Jessica M Scott
    Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, British Columbia, Canada
    Med Sci Sports Exerc 40:1400-7. 2008
    ..Although further mechanistic investigations are clearly warranted, several key mechanisms have received support for at least a partial contribution to the transient changes in myocardial performance often observed after PSE...
  99. ncbi Panax notoginseng supplementation enhances physical performance during endurance exercise
    Michael T C Liang
    Department of Kinesiology and Health Promotion, California State Polytechnic University, Pomona, California 91768, USA
    J Strength Cond Res 19:108-14. 2005
    ..6 +/- 8 ml.kg-1.min-1) during endurance cycle exercise. Based on this study, we conclude that 1,350 mg per day PNG supplement for 30 days improved endurance time to exhaustion, and lowered MAP and Vo2 during endurance exercise...
  100. ncbi Exercise training from late middle age until senescence does not attenuate the declines in skeletal muscle aerobic function
    Andrew C Betik
    Muscle and Aging Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, T2N 1N4, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R744-55. 2009
    ....
  101. ncbi n-3 polyunsaturated fatty acids do not alter immune and inflammation measures in endurance athletes
    David C Nieman
    Dept of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Int J Sport Nutr Exerc Metab 19:536-46. 2009
    ....

Research Grants71

  1. Effect of leg strengthening exercise after hip fracture
    KATHLEEN MANGIONE; Fiscal Year: 2004
    ..Muscle weakness, loss of balance and decreased physical endurance remain...
  2. MOLECULAR GENETICS OF THERMOGENESIS
    MARTIN ELLIOT YOUNG; Fiscal Year: 2013
    ..Mice with a global inactivation of Slc25a25 are resistant to DIO and have reduced physical endurance when tested on a treadmill...
  3. ROCK and Obesity
    JAMES KUANG JAN LIAO; Fiscal Year: 2013
    ..by or involve with the upregulation of PGC-11 such as the fasting state, adaptive thermogenesis, and physical endurance are defective in ROCK2 mice...
  4. Exercise Versus Cognitive Interventions for Elders at Risk for Dementia
    David Loewenstein; Fiscal Year: 2010
    ..with MCI;2) a broad array of outcome variables will be examined including measures of cognitive functioning, physical endurance and fitness, biological activity (e.g...
  5. Frequency of aerobic/resistance training in older women
    Gary Hunter; Fiscal Year: 2009
    ..Such information is critical to our understanding of ways to improve well being, quality of life, and independence of an aging population. ..
  6. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
  7. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2008
    ..abstract_text> ..
  8. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
  9. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
    ..Data from these patient- oriented studies have implications related to understanding the contribution of endothelial function in a variety of common diseases. ..
  10. Exercise Substrate Utilization:The Crossover Concept
    George Brooks; Fiscal Year: 2006
    ..Further, we have the auxiliary personnel and facilities to conduct longitudinal training studies ..
  11. Estimating Joint Impedance from the Surface EMG
    EDWARD CLANCY; Fiscal Year: 2004
    ..abstract_text> ..
  12. Pre-habilitation of Aged and Young Neuromuscular Systems
    MICHAEL DESCHENES; Fiscal Year: 2005
    ....
  13. Task Dependence of Muscle Fatigue in Older Adults
    Sandra Hunter; Fiscal Year: 2005
    ..These preliminary findings will form the foundation for an RO 1 application that will further explore the mechanisms and task dependency of muscle fatigue in older adults. ..
  14. Effect of Daily Exercise on Cardiac Autonomic Regulation
    GEORGE BILLMAN; Fiscal Year: 2005
    ..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..
  15. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  16. Noninvasive Motor Unit Discharge Assessment
    EDWARD CLANCY; Fiscal Year: 2004
    ..The long-term goal is to develop a non-invasive system for recording a complete set of MU discharge characteristics. This system should lead to applications in areas such as ergonomics, clinical EMG, and basic motor control research. ..
  17. Reducing Risk Factors in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ....
  18. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
  19. Dietary Omega-3 Fatty Acids and Sudden Cardiac Death
    GEORGE EDWARD BILLMAN; Fiscal Year: 2010
    ..This project will also determine the effectiveness of fish oil supplements in reducing sudden death due to a lethal abnormal heart rhythm after a heart attack. ..
  20. CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIES
    Jerome Dempsey; Fiscal Year: 2002
    ..These latter studies conduced in sleep are important to testing the sensitivity of respiratory control mechanisms to mechanical feedback-a problem which remains relatively unexplored, especially in the human. ..
  21. The Effect of Statins on Skeletal Muscle Function
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ....
  22. Exercise for Mental Health: Does Exercise Make People Feel Better?
    Panteleimon Ekkekakis; Fiscal Year: 2003
    ..The immediate anticipated benefit of this research is the development of physical activity public health recommendations that incorporate affect as a fundamental consideration. ..
  23. Neuromuscular Fatigue in Older Adults
    Sandra Hunter; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  24. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  25. Mechanisms to Induce Islet Proliferation
    PATRICK FUEGER; Fiscal Year: 2008
    ..This award will be an instrumental component towards my ultimate goal of pursuing a career in diabetes research. [unreadable] [unreadable]..
  26. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
    ..abstract_text> ..
  27. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
    ..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
  28. Mechanical Ventilation and Diaphragmatic Oxidant Injury
    Scott Powers; Fiscal Year: 2008
    ..abstract_text> ..
  29. Physiological Signals to MCT Expression
    George Brooks; Fiscal Year: 2008
    ..Aim 3 studies will involve comparisons of the levels of muscle MCT pre-mRNAs, mRNAs and protein levels. We have the tools to achieve the stated aims. ..
  30. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  31. Microvascular Permeability and Sex
    VIRGINIA HUXLEY; Fiscal Year: 2008
    ....
  32. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2007
    ..These data could ultimately lead to more efficient use of physical activity and body weight control in the primary and secondary prevention of hypertension. ..
  33. Testing the Validity of a Construct of Geriatric Frailty
    CATHERINE SARKISIAN; Fiscal Year: 2008
    ..In summary, this exploratory investigation offers a unique and cost-effective means to break new ground in our understanding of the geriatric syndrome of frailty. [unreadable] [unreadable] [unreadable]..
  34. Plaque Characterization with Vascular MR Micro-Coils
    David Wilson; Fiscal Year: 2006
    ..g., fibro-fatty plaque, advanced necrotic core, or unstable fibrous cap) and determine its vulnerability for rupture, which can be a life threatening event. [unreadable] [unreadable] [unreadable]..
  35. Inflamation-Gene Expression by Monocytes in Frailty
    Sean Leng; Fiscal Year: 2005
    ..Therefore, It will serve as a hypothesis-generating project, and a basis for hypothesis refinement, that will open new pathways for future mechanistic and, potentially, interventional investigations of frailty in old age. ..
  36. MULTIMEDIA ELDERCARE SUPPORT FOR FAMILY CAREGIVERS
    A Irvine; Fiscal Year: 2004
    ..The award-winning Phase I prototype will be marketed as a CD-ROM and in Internet/Intranet format. The Phase II program also will be produced in these formats. ..
  37. ECONOMIC IMPACT OF INJURY/ILLNESS IN CAREER ROOFERS
    Laura Welch; Fiscal Year: 2004
    ..5) Assess and describe the impact of work-related conditions and aging on the ability of roofers to remain employed in their trade. ..
  38. CARE OF THE AGED: A MULTIMEDIA STAFF DEVELOPMENT PROGRAM
    A Irvine; Fiscal Year: 2002
    ..In Phase II, the program's content will be expanded, and it will be evaluated with a randomized trial at multiple residential worksites. PROPOSED COMMERCIAL APPLICATION: Not available ..
  39. RESPIRATION AND GLYCOLYSIS--INTEGRATION IN ACTIVE MUSCLE
    Kevin Conley; Fiscal Year: 2002
    ..g., diabetes. An understanding of the integration of metabolism in healthy tissue is the first step to understanding how failure of integration limits function in diseased muscle. ..
  40. Estrogen and Sympathetically Mediated Vasoconstriction
    PAUL FADEL; Fiscal Year: 2004
    ..abstract_text> ..
  41. Quantifying Oxidative Metabolism in Diabetic Muscle
    BRUCE DAMON; Fiscal Year: 2005
    ..Moreover, these techniques will be suitable for future studies of the effects of exercise training or other interventions in diabetic animal models. ..
  42. Emotional Reactivity: A Trigger of Atrial Fibrillation
    Rachel Lampert; Fiscal Year: 2008
    ..Determining triggers of AF, and identifying individuals at increased risk of recurrence, may lead to future therapeutic interventions aimed at decreasing the effects of triggers on the individual patient. ..
  43. Cooperative Lifestyle Intervention Program
    WALTER REJESKI; Fiscal Year: 2009
    ..Analyses will also be conducted to determine whether changes in the primary outcome are mediated by changes in constructs from social cognitive theory. ..
  44. GENETIC FACTORS RESPONSIBLE FOR EXERCISE ENDURANCE
    J Lightfoot; Fiscal Year: 2009
    ..This will be the first project investigating the genetic basis of exercise endurance to use these techniques that have already proven successful in other fields. ..
  45. Phosphorus MRI of the Lower Extremeties in Diabetics
    ROBERT GREENMAN; Fiscal Year: 2003
    ..abstract_text> ..
  46. Intelligent Systems for Detection of Aging Changes
    Jeffrey A Kaye; Fiscal Year: 2010
    ....
  47. Tai Chi and Dual Task Interference on Postural Control in Parkinson's Disease
    CHRISTOPHER HASS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  48. TISSUE RESPONSE IN IMRI GUIDED CANCER THERAPY
    David Wilson; Fiscal Year: 2003
    ..With this research, the applicants expect to establish an analysis paradigm suitable for many future studies of contrast agents, ablation techniques, localized drug release, and other iMRI-guided therapies. ..
  49. AGING, HABITUAL EXERCISE, AND ARTERIAL COMPLIANCE
    Hirofumi Tanaka; Fiscal Year: 2002
    ....
  50. Trial to Increase Walking Among Sedentary Older Latinos
    CATHERINE SARKISIAN; Fiscal Year: 2008
    ..The goal of this project is to demonstrate success of a feasible intervention that raises and sustains walking levels among older Latinos. ..
  51. Cryo-Imaging of Fluorescently Tagged Cells in the Mouse
    David Wilson; Fiscal Year: 2006
    ..This system will help researchers understand physiology and disease mechanisms and promote research for cures. [unreadable] [unreadable] [unreadable]..
  52. Multimedia Support for Caregivers of the Seriously Ill
    A Irvine; Fiscal Year: 2007
    ..The proposed program provides automates support and education for the caregivers via the Internet, including articles, videos, and help thinking through tough decisions. [unreadable] [unreadable] [unreadable]..
  53. MRI Detection of Skeletal Muscle Microvascular Dysfunction
    BRUCE DAMON; Fiscal Year: 2007
    ..In these studies we will be developing new methods for studying blood flow to muscles non-invasively. [unreadable] [unreadable] [unreadable]..
  54. Intervention to Raise Octogenarians' Walking Levels
    CATHERINE SARKISIAN; Fiscal Year: 2006
    ..Sarkisian will conduct a small RCT of the modified intervention with 60 octogenarians recruited from senior residential facilities to obtain preliminary data that would guide the design of a larger RCT. [unreadable] [unreadable]..
  55. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2008
    ..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. [unreadable] [unreadable]..
  56. EFFECT OF POTASSIUM BICARBONATE ON BONE AND MUSCLE
    Bess Dawson Hughes; Fiscal Year: 2008
    ....
  57. Weight-loss, Exercise, and Oxidative Capacity in Obesity
    Matthew Harber; Fiscal Year: 2005
    ..lean subjects. The obese women will then be reevaluated following 12% weight loss (through diet only or diet plus exercise) to examine the influence of weight-loss with or without exercise on these parameters. ..
  58. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
    ..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
  59. Oxidant induced gene expression in vitamin E deficient *
    Kishorchandra Gohil; Fiscal Year: 2002
    ..These molecular data may provide the basis for designing more effective protocols for dietary interventions with antioxidants that might ameliorate lung diseases induced by environmental oxidants. ..
  60. Physical Work Capacity After Traumatic Brain Injury
    KURT MOSSBERG; Fiscal Year: 2009
    ..The latter is of particular importance from a public health perspective since the individual with TBI is usually young and will endure the permanent disabling effects of TBI for many years. ..
  61. Molecular determinants of exercise-induced muscle damage
    Monica Hubal; Fiscal Year: 2004
    ..Understanding these processes could lead to novel treatments for musculodystrophy and other myopathies that are characterized by muscle degradation. ..
  62. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2001
    ....
  63. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2005
    ..The design of these studies will increase our understanding of how the vestibular system contributes to orthostatic blood pressure regulation in humans. ..
  64. Leukemia inhibitor factor in skeletal muscle regrowth
    Espen Spangenburg; Fiscal Year: 2003
    ..Identification of a cytokine and a signaling mechanism that may regulate muscle growth could lead to other counter-measures to ultimately prevent muscle wasting. ..
  65. Gene Therapy of Muscle Wasting From Uremia
    Xiaonan Wang; Fiscal Year: 2005
    ..We believe that the experimental results will shed the insight on the mechanisms of muscle protein degradation, and provide a possible new approach to treat the pathological process of muscle wasting. ..
  66. Regulation of skeletal alpha actin expression during mu*
    Espen Spangenburg; Fiscal Year: 2008
    ..The overall goal is to determine the role IGF-I may have in activating transcriptional activity during muscle regrowth. ..
  67. Physical Activity during Pregnancy, Fetal Growth, and Toddler Body Size
    Lanay Mudd; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..