muscle development

Summary

Summary: Developmental events leading to the formation of adult muscular system, which includes differentiation of the various types of muscle cell precursors, migration of myoblasts, activation of myogenesis and development of muscle anchorage.

Top Publications

  1. pmc Muscle-specific microRNA miR-206 promotes muscle differentiation
    Hak Kyun Kim
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 174:677-87. 2006
  2. ncbi Cellular and molecular regulation of muscle regeneration
    Sophie B P Chargé
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Physiol Rev 84:209-38. 2004
  3. pmc NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma
    Huating Wang
    Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 14:369-81. 2008
  4. ncbi Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
    Aaron W B Joe
    The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver BC, V6T 1Z3, Canada
    Nat Cell Biol 12:153-63. 2010
  5. pmc microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7
    Jian Fu Chen
    McAllister Heart Institute, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 190:867-79. 2010
  6. ncbi MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis
    Chung Fai Wong
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, QLD, Australia
    J Biol Chem 283:9836-43. 2008
  7. pmc MIR-206 regulates connexin43 expression during skeletal muscle development
    Curtis Anderson
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miller School of Medicine, Gautier Building 303, 1011 NW 15 Street, Miami, FL 33136, USA
    Nucleic Acids Res 34:5863-71. 2006
  8. pmc Regulation of myostatin activity and muscle growth
    S J Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:9306-11. 2001
  9. ncbi Direct isolation of satellite cells for skeletal muscle regeneration
    Didier Montarras
    CNRS Unité de Recherche Associée 2578, Department of Developmental Biology, INSERM, Pasteur Institute, 75724 Paris Cedex 15, France
    Science 309:2064-7. 2005
  10. ncbi Muscle satellite cells are primed for myogenesis but maintain quiescence with sequestration of Myf5 mRNA targeted by microRNA-31 in mRNP granules
    Colin G Crist
    CNRS URA 2578, Department of Developmental Biology, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Cell Stem Cell 11:118-26. 2012

Detail Information

Publications290 found, 100 shown here

  1. pmc Muscle-specific microRNA miR-206 promotes muscle differentiation
    Hak Kyun Kim
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 174:677-87. 2006
    ..In addition, inhibitors of myogenic transcription factors, Id1-3 and MyoR, are decreased upon miR-206 introduction, suggesting the presence of additional mechanisms by which microRNAs enforce the differentiation program...
  2. ncbi Cellular and molecular regulation of muscle regeneration
    Sophie B P Chargé
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Physiol Rev 84:209-38. 2004
    ..In particular, bone marrow-derived and muscle-derived stem cells contribute to new myofiber formation and to the satellite cell pool after injury...
  3. pmc NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma
    Huating Wang
    Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 14:369-81. 2008
    ..Together, these results identify a NF-kappaB-YY1-miR-29 regulatory circuit whose disruption may contribute to RMS...
  4. ncbi Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
    Aaron W B Joe
    The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver BC, V6T 1Z3, Canada
    Nat Cell Biol 12:153-63. 2010
    ..In summary, FAPs expand upon damage to provide a transient source of pro-differentiation signals for proliferating myogenic progenitors...
  5. pmc microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7
    Jian Fu Chen
    McAllister Heart Institute, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 190:867-79. 2010
    ..Therefore, our experiments suggest that microRNAs participate in a regulatory circuit that allows rapid gene program transitions from proliferation to differentiation...
  6. ncbi MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis
    Chung Fai Wong
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, QLD, Australia
    J Biol Chem 283:9836-43. 2008
    ..These results reveal a model of regulation during myogenesis whereby the up-regulation of miR-26a acts to post-transcriptionally repress Ezh2, a known suppressor of skeletal muscle cell differentiation...
  7. pmc MIR-206 regulates connexin43 expression during skeletal muscle development
    Curtis Anderson
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miller School of Medicine, Gautier Building 303, 1011 NW 15 Street, Miami, FL 33136, USA
    Nucleic Acids Res 34:5863-71. 2006
    ..is involved in myogenesis, in this work we show that miR-206 is also upregulated during perinatal skeletal muscle development in mice in vivo and that both miR-1 and miR-206 downregulate Cx43 expression during myoblast fusion in vitro...
  8. pmc Regulation of myostatin activity and muscle growth
    S J Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:9306-11. 2001
    ..Our findings suggest that the propeptide, follistatin, or other molecules that block signaling through this pathway may be useful agents for enhancing muscle growth for both human therapeutic and agricultural applications...
  9. ncbi Direct isolation of satellite cells for skeletal muscle regeneration
    Didier Montarras
    CNRS Unité de Recherche Associée 2578, Department of Developmental Biology, INSERM, Pasteur Institute, 75724 Paris Cedex 15, France
    Science 309:2064-7. 2005
    ..Such cells, grafted into muscles of mdx nu/nu mice, contributed both to fiber repair and to the muscle satellite cell compartment. Expansion of these cells in culture before engraftment reduced their regenerative capacity...
  10. ncbi Muscle satellite cells are primed for myogenesis but maintain quiescence with sequestration of Myf5 mRNA targeted by microRNA-31 in mRNP granules
    Colin G Crist
    CNRS URA 2578, Department of Developmental Biology, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Cell Stem Cell 11:118-26. 2012
    ..We therefore propose a model in which posttranscriptional mechanisms hold quiescent stem cells poised to enter a tissue-specific differentiation program...
  11. pmc MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle development, function, and disease
    W H Davin Townley-Tilson
    University of North Carolina, Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, Chapel Hill, NC 27599, USA
    Int J Biochem Cell Biol 42:1252-5. 2010
    ..Many studies demonstrate that these miRNAs are necessary for proper skeletal and cardiac muscle development and function, and have a profound influence on multiple myopathies, such as hypertrophy, dystrophy, and ..
  12. pmc miR-206 and -486 induce myoblast differentiation by downregulating Pax7
    Bijan K Dey
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Jordan Hall 1232, Charlottesville, VA 22908, USA
    Mol Cell Biol 31:203-14. 2011
    ..Since both these microRNAs are induced by MyoD and since Pax7 promotes the expression of Id2, an inhibitor of MyoD, our results revealed a bistable switch that exists either in a Pax7-driven myoblast state or a MyoD-driven myotube state...
  13. pmc Genome-wide remodeling of the epigenetic landscape during myogenic differentiation
    Patrik Asp
    Department of Pathology and Cancer Institute, New York University School of Medicine, 522 First Avenue, Smilow Research Building 1104, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 108:E149-58. 2011
    ....
  14. pmc MicroRNA control of muscle development and disease
    Andrew H Williams
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Curr Opin Cell Biol 21:461-9. 2009
    Cardiac and skeletal muscle development are controlled by evolutionarily conserved networks of transcription factors that coordinate the expression of genes involved in muscle growth, morphogenesis, differentiation, and contractility...
  15. ncbi A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis
    Andrew S Brack
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305 5235 USA
    Cell Stem Cell 2:50-9. 2008
    ....
  16. pmc TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4
    Catherine E Winbanks
    Division of Metabolism and Obesity, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    J Biol Chem 286:13805-14. 2011
    ..These findings identify a novel mechanism of interaction between TGF-β and miR-206 and -29 in the regulation of myogenic differentiation through HDAC4...
  17. pmc Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells
    Aster H Juan
    Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 36:61-74. 2009
    ..Thus, miR-214 and Ezh2 establish a regulatory loop controlling PcG-dependent gene expression during differentiation...
  18. pmc MicroRNA-206: the skeletal muscle-specific myomiR
    John J McCarthy
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Biochim Biophys Acta 1779:682-91. 2008
    ..The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle...
  19. pmc IGF-II is regulated by microRNA-125b in skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 192:69-81. 2011
    ....
  20. ncbi The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 3:397-409. 2002
    ....
  21. pmc Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration
    Kathleen Kelly Tanaka
    MCD Biology, University of Colorado, Boulder, CO 80309, USA
    Cell Stem Cell 4:217-25. 2009
    ....
  22. ncbi Many routes to the same destination: lessons from skeletal muscle development
    Gi Fay Mok
    Division of Animal Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK
    Reproduction 141:301-12. 2011
    ..This review will highlight how cells from multiple distinct starting points can converge on a common set of regulators to generate skeletal muscle...
  23. ncbi A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development
    Thomas Sandmann
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Dev Cell 10:797-807. 2006
    ..To understand how these transcription factors control diverse processes in muscle development, we have combined chromatin immunoprecipitation analysis with gene expression profiling to obtain a temporal ..
  24. ncbi MyoD and the transcriptional control of myogenesis
    Charlotte A Berkes
    Colorado College, Colorado Springs, CO 80903, USA
    Semin Cell Dev Biol 16:585-95. 2005
    ..helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for ..
  25. ncbi The genetics of vertebrate myogenesis
    Robert J Bryson-Richardson
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    Nat Rev Genet 9:632-46. 2008
    ..Collectively, these studies have opened a window into the morphogenetic and molecular bases of the different phases of vertebrate myogenesis, from embryo to adult...
  26. ncbi Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development
    Kathryn J Mitchell
    Myology Group, UMR S 787 INSERM, Universite Pierre et Marie Curie Paris VI, Paris, 75634, France
    Nat Cell Biol 12:257-66. 2010
    ..Taken together, our findings uncover a new and anatomically identifiable population of muscle progenitors and define a key role for Pax7 in a non-satellite cell population during postnatal muscle growth...
  27. ncbi Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins
    B L Black
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Annu Rev Cell Dev Biol 14:167-96. 1998
    ..We discuss the diverse functions of this family of transcription factors, the ways in which they are regulated, and their mechanisms of action...
  28. pmc Microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells
    Beatrice Cardinali
    Istituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
    PLoS ONE 4:e7607. 2009
    ..miRNAs have been shown to play crucial roles in muscle development and in regulation of muscle cell proliferation and differentiation.
  29. pmc Gene expression during normal and FSHD myogenesis
    Koji Tsumagari
    Human Genetics Program, Tulane Medical School, New Orleans, LA, USA
    BMC Med Genomics 4:67. 2011
    ..Within each repeat unit is a gene, DUX4, that can encode a protein containing two homeodomains. A DUX4 transcript derived from the last repeat unit in a contracted array is associated with pathogenesis but it is unclear how...
  30. ncbi Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133
    Dylan Sweetman
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK
    Dev Biol 321:491-9. 2008
    ..Taken together our results demonstrate differential requirements of distinct MRFs for the induction of microRNA gene expression during skeletal myogenesis...
  31. ncbi Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB
    R C Langen
    Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    FASEB J 15:1169-80. 2001
    ..These results demonstrate that inflammatory cytokines may contribute to muscle wasting through the inhibition of myogenic differentiation via a NF-kappaB-dependent pathway...
  32. pmc RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy
    Lauren Snider
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 18:2414-30. 2009
    ..Together, we have identified new sense and anti-sense RNA transcripts, novel mRNAs and mi/siRNA-sized RNA fragments generated from the D4Z4 units that are new candidates for the pathophysiology of FSHD...
  33. pmc MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development
    Paul L Boutz
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:71-84. 2007
    ..These results indicate that miR-133 directly down-regulates a key splicing factor during muscle development and establishes a role for microRNAs in the control of a developmentally dynamic splicing program.
  34. ncbi Molecular signature of quiescent satellite cells in adult skeletal muscle
    So ichiro Fukada
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Stem Cells 25:2448-59. 2007
    ..Our data provide roles of CTR in quiescent satellite cells and a solid scaffold to further dissect molecular regulation of satellite cells. Disclosure of potential conflicts of interest is found at the end of this article...
  35. ncbi Bone marrow stromal cells generate muscle cells and repair muscle degeneration
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
    Science 309:314-7. 2005
    ..These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow...
  36. pmc Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation
    Eusebio Perdiguero
    Differentiation and Cancer Program, Center for Genomic Regulation CRG PRBB, Barcelona, Spain
    EMBO J 26:1245-56. 2007
    ..This study provides novel evidence of a fundamental role of p38alpha in muscle formation in vitro and in vivo...
  37. ncbi The molecular regulation of myogenesis
    L A Sabourin
    Institute for Molecular Biology and Biotechnology, MOBIX, McMaster University, Hamilton, Ontario, Canada
    Clin Genet 57:16-25. 2000
    ..This has put forward the hypothesis that these factors also play specific biological roles following muscle injury and repair...
  38. pmc Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatness
    Xiao Zhao
    State Key Laboratory of Biocontrol, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    PLoS ONE 6:e19774. 2011
    ..and between breeds differing in muscle growth is necessary to uncover the complex mechanism underlying muscle development. Herein, we present the first transcriptome-wide longissimus dorsi muscle development research concerning ..
  39. pmc The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation
    Riccardo Taulli
    Department of Anatomy, Pharmacology and Forensic Medicine, and Center for Experimental Research and Medical Studies, University of Torino, Torino, Italy
    J Clin Invest 119:2366-78. 2009
    ....
  40. ncbi Distinct and dynamic myogenic populations in the vertebrate embryo
    Margaret Buckingham
    Institut Pasteur, CNRS URA 2578, 28 rue du Dr Roux, 75015 Paris, France
    Curr Opin Genet Dev 19:444-53. 2009
    ..Further insights into myogenic populations that contribute to trunk and limb development at different stages are summarized and the distinct regulatory networks that underlie the formation of head muscles are discussed...
  41. ncbi Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model
    Tomoyuki Nakasa
    Department of Orthopaedic Surgery, Programs for Applied Biomedicine, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Cell Mol Med 14:2495-505. 2010
    ..Muscle-specific miRNA, miRNA (miR)-1, miR-133 and miR-206 play a crucial role in the regulation of muscle development and homeostasis...
  42. ncbi Altered myogenesis in Six1-deficient mice
    Christine Laclef
    Departement Genetique, Developpement et Pathologie Moleculaire, Institut Cochin INSERM 567, CNRS UMR 8104, Universite Paris V, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Development 130:2239-52. 2003
    ..It appears therefore that Six1 plays a specific role in hypaxial muscle differentiation, distinct from those of other hypaxial determinants such as Pax3, cMet, Lbx1 or Mox2...
  43. pmc A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
    Tadahiro Kitamura
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:2477-85. 2007
    ..Notch/Foxo1 cooperation may integrate environmental cues through Notch with metabolic cues through Foxo1 to regulate progenitor cell maintenance and differentiation...
  44. pmc MicroRNA transcriptome profiles during swine skeletal muscle development
    Tara G McDaneld
    USDA ARS Meat Animal Research Center, Clay Center, NE, USA
    BMC Genomics 10:77. 2009
    ..To evaluate the role of miR in skeletal muscle of swine, global microRNA abundance was measured at specific developmental stages including proliferating satellite cells, three stages of fetal growth, day-old neonate, and the adult...
  45. ncbi The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 75015 Paris, France
    Annu Rev Cell Dev Biol 23:645-73. 2007
    ..Recent results have underlined the importance of the Pax3/7 population of cells for skeletal muscle development and regeneration...
  46. pmc Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
    Yuting Sun
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    J Cell Biol 189:1157-69. 2010
    Mammalian target of rapamycin (mTOR) has emerged as a key regulator of skeletal muscle development by governing distinct stages of myogenesis, but the molecular pathways downstream of mTOR are not fully understood...
  47. ncbi Inhibition of miR-214 expression represses proliferation and differentiation of C2C12 myoblasts
    Yang Feng
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, China
    Cell Biochem Funct 29:378-83. 2011
    ..miRNAs) are small non-coding RNAs that participate in diverse biological processes including skeletal muscle development. MiR-214 is an miRNA that is differentially expressed in porcine embryonic muscle and adult skeletal muscle, ..
  48. ncbi Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies
    Chun Hong Zhu
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Aging Cell 6:515-23. 2007
    ..We demonstrate that it functions as well as young myoblasts in xenotransplant experiments in immunocompromized mice under conditions of regeneration following muscle damage...
  49. ncbi Epigenetics: DNA demethylation promotes skeletal myotube maturation
    Marlinda Hupkes
    Department of Cell and Applied Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
    FASEB J 25:3861-72. 2011
    ..Our data suggest that genomic demethylation induced by 5AC overcomes an epigenetic barrier that prevents untreated C2C12 myotubes from reaching full maturity...
  50. pmc Skeletal muscle satellite cells and adult myogenesis
    Fabien Le Grand
    Sprott Center for Stem Cell Research, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, K1H 8L6 Ontario, Canada
    Curr Opin Cell Biol 19:628-33. 2007
    ..New reports also demonstrate satellite cells relationships with blood vessels and the high myogenic potential of stem cell subsets related to both lineages...
  51. ncbi Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of disease
    Claudia Seger
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom
    Dev Dyn 240:2440-51. 2011
    ..We also analyzed Pax7(+ve) cells in animals with dystrophic phenotypes and found an increased number compared with wild-type...
  52. ncbi Functional skeletal muscle regeneration from differentiating embryonic stem cells
    Radbod Darabi
    Department of Developmental Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9133, USA
    Nat Med 14:134-43. 2008
    ..These data demonstrate the therapeutic potential of ES cells in muscular dystrophy...
  53. pmc Decreased miR-29 suppresses myogenesis in CKD
    XIAONAN H WANG
    Renal Division, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 22:2068-76. 2011
    ..These data suggest a potential mechanism for the impaired muscle cell differentiation associated with CKD...
  54. pmc A novel target of microRNA-29, Ring1 and YY1-binding protein (Rybp), negatively regulates skeletal myogenesis
    Liang Zhou
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China
    J Biol Chem 287:25255-65. 2012
    ..Collectively, our results identify Rybp as a novel regulator of myogenesis that co-acts with YY1 to silence miR-29 and other myogenic loci...
  55. pmc MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration
    Mayssa H Mokalled
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Genes Dev 26:190-202. 2012
    ..Our results provide new insights into the genetic circuitry of muscle regeneration and identify MASTR as a central regulator of this process...
  56. pmc AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep
    Mei J Zhu
    Department of Animal Science and Interdepartmental Molecular and Cellular Life Sciences Program, University of Wyoming, Laramie, WY 82071, USA
    J Physiol 586:2651-64. 2008
    ..In summary, we have demonstrated decreased signalling of the AMPK system in skeletal muscle of fetuses of OB mothers, which may play a role in altered muscle development and development of insulin resistance in the offspring.
  57. pmc Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency
    Anna Polesskaya
    Centre National de la Recherche Scientifique CNRS FRE 2944, Institut Andre Lwoff, Villejuif F 94801, France
    Genes Dev 21:1125-38. 2007
    ..Our results unravel novel mechanisms of translational regulation in skeletal muscle and suggest that Lin-28 performs the role of "translational enhancer" in embryonic and adult cells and tissues...
  58. pmc Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants
    Karin Schuster-Gossler
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, D 30625 Lower Saxony, Germany
    Proc Natl Acad Sci U S A 104:537-42. 2007
    ....
  59. pmc Myogenic specification of side population cells in skeletal muscle
    Atsushi Asakura
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6 Canada
    J Cell Biol 159:123-34. 2002
    ....
  60. pmc Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin
    Karen A M Kennedy
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    BMC Biol 7:67. 2009
    ..Thus, the purpose of this study is to examine the molecular mechanisms by which RA enhances skeletal myogenesis and interacts with Wnt and BMP4 signalling during P19 or mouse embryonic stem (ES) cell differentiation...
  61. pmc NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes
    Huating Wang
    Human Cancer Genetics Program, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 27:4374-87. 2007
    ..Based on these results, we propose that NF-kappaB regulation of YY1 and transcriptional silencing of myofibrillar genes represent a new mechanism by which NF-kappaB functions in myoblasts to modulate skeletal muscle differentiation...
  62. pmc Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation
    Chang Hao Cui
    Department of Reproductive Biology and Pathology, National Institute for Child Health and Development, Tokyo, 157 8535, Japan
    Mol Biol Cell 18:1586-94. 2007
    ..These results demonstrate that the endometrial progenitor cells and menstrual blood-derived cells can transfer dystrophin into dystrophied myocytes through cell fusion and transdifferentiation in vitro and in vivo...
  63. pmc Pax3/Pax7 mark a novel population of primitive myogenic cells during development
    Lina Kassar-Duchossoy
    Department of Developmental Biology, Pasteur Institute, Centre Nationale de la Recherche Scientifique Unité de Recherche Associeé 2578, 75724 Paris, Cedex 15, France
    Genes Dev 19:1426-31. 2005
    ..These findings identify critical cell populations during lineage restriction, and provide a framework for defining myogenic cell states for therapeutic studies...
  64. ncbi Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome
    Claire Niro
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Dev Biol 338:168-82. 2010
    ..This in vivo wide transcriptomal analysis of the function of the master myogenic determinants, Six, identifies them as novel markers for the differential activation of a specific muscle program during mammalian somitic myogenesis...
  65. pmc UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis
    Shayesta Seenundun
    Regenerative Medicine Program, Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    EMBO J 29:1401-11. 2010
    ..Thus, removal of repressive H3K27me3 marks by UTX occurs through targeted recruitment followed by spreading across the gene...
  66. pmc Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation
    Yubing Liu
    Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
    Nucleic Acids Res 38:6857-71. 2010
    ..To this day little is known regarding the exact molecular mechanism by which SIX factors regulate muscle development. We have conducted a functional genomic study of the role played by SIX1 and SIX4 during the differentiation ..
  67. pmc Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis
    Shihuan Kuang
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    J Cell Biol 172:103-13. 2006
    ....
  68. pmc LongSAGE analysis of skeletal muscle at three prenatal stages in Tongcheng and Landrace pigs
    Zhonglin Tang
    Department of Gene and Cell Engineering, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, PR China
    Genome Biol 8:R115. 2007
    ..Prenatal muscle development programs postnatal performance...
  69. pmc MicroRNA-148a promotes myogenic differentiation by targeting the ROCK1 gene
    Jing Zhang
    State Key Laboratory for Animal Nutrition, The Key Laboratory for Domestic Animal Genetic Resources and Breeding of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China
    J Biol Chem 287:21093-101. 2012
    ..that post-transcriptionally regulate gene expression and have emerged as critical regulators of skeletal muscle development. Here, we identified miR-148a as a novel myogenic microRNA that mediated myogenic differentiation...
  70. ncbi Transforming growth factor-beta and myostatin signaling in skeletal muscle
    Helen D Kollias
    Department of Neurology, Johns Hopkins Hospital, Baltimore, MD, USA
    J Appl Physiol (1985) 104:579-87. 2008
    ..we will review recent advances in our understanding of the TGF-beta and myostatin signaling pathways and, in particular, focus on the implications of this signaling pathway for skeletal muscle development, physiology, and pathology.
  71. pmc Smad7 promotes and enhances skeletal muscle differentiation
    Helen D Kollias
    Department of Biology, 327 Farquharson, LSB, York University, 4700 Keele St, Toronto M3J 1P3 Ontario, Canada
    Mol Cell Biol 26:6248-60. 2006
    ..Taken together, these data implicate Smad7 as a fundamental regulator of differentiation in skeletal muscle cells...
  72. pmc The actin regulator N-WASp is required for muscle-cell fusion in mice
    Yael Gruenbaum-Cohen
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 109:11211-6. 2012
    ..WASp-family elements appear therefore to act as universal mediators of the myogenic cell-cell fusion mechanism underlying formation of functional muscle fibers, in both vertebrate and invertebrate species...
  73. pmc A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb
    Lola Bajard
    Centre National de la Recherche Scientifique URA 2578, Department of Developmental Biology, Pasteur Institute, 75015 Paris, France
    Genes Dev 20:2450-64. 2006
    ..Mutation of the Pax3 site abolishes all expression controlled by the 145-bp sequence in transgenic mouse embryos. We conclude that Pax3 directly regulates Myf5 in the hypaxial somite and its derivatives...
  74. ncbi Retinoic acid enhances skeletal myogenesis in human embryonic stem cells by expanding the premyogenic progenitor population
    Tammy Ryan
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada
    Stem Cell Rev 8:482-93. 2012
    ..We propose that RA could fit into a directed culture method for deriving skeletal muscle from hESCs...
  75. pmc Epigenetic regulation of satellite cell activation during muscle regeneration
    F Jeffrey Dilworth
    Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Mailbox 511, Ottawa, Ontario, Canada K1H 8L6
    Stem Cell Res Ther 2:18. 2011
    ....
  76. pmc MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiation
    Jeffrey Gagan
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 286:19431-8. 2011
    ..MyoR and miR-378 were anticorrelated during cardiotoxin-induced adult muscle regeneration in mice. Taken together, this shows a feed-forward loop where MyoD indirectly down-regulates MyoR via miR-378...
  77. ncbi Epigenetic regulation of myogenesis
    Eusebio Perdiguero
    Department of Experimental and Health Sciences, Pompeu Fabra University UPF, CIBER on Neurodegenerative diseases CIBERNED, Barcelona, Spain
    Epigenetics 4:541-50. 2009
    ..These studies are increasing our understanding of how muscle lineage-specific information encoded in chromatin merges with muscle regulatory factors to drive muscle stem cells through transitions during myogenesis...
  78. pmc MicroRNAs in skeletal muscle: their role and regulation in development, disease and function
    Isabelle Güller
    Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood 3125, Australia
    J Physiol 588:4075-87. 2010
    ..muscle to consistently function at optimal levels, the efficient activation of processes that regulate muscle development, growth, regeneration and metabolism is required...
  79. pmc MyoD directly up-regulates premyogenic mesoderm factors during induction of skeletal myogenesis in stem cells
    Peter J Gianakopoulos
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 286:2517-25. 2011
    ..Taken together, MyoD directs stem cells into the skeletal muscle lineage by binding and activating the expression of premyogenic mesoderm genes, prior to activating myoblast genes...
  80. ncbi Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development
    Riadh Lobbardi
    Ecole Normale Superieure, Institut de Biologie, 46 rue d Ulm, 75005 Paris, France
    Development 138:1783-94. 2011
    ..Here, we report for the first time the role of the STAR family RNA-binding protein Quaking A (QkA) in somite muscle development. We show in zebrafish that the loss of QkA function affects fast muscle fiber maturation as well as Hh-..
  81. pmc Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C
    Ashraf Said Al Madhoun
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    EMBO J 30:2477-89. 2011
    ..This work identifies the first kinase that regulates MyoD and Myf5 expression in ES or satellite cells...
  82. ncbi Skeletal muscle stem cells in developmental versus regenerative myogenesis
    S Tajbakhsh
    Stem Cells and Development, Department of Developmental Biology, Pasteur Institute, CNRS URA, Paris, France
    J Intern Med 266:372-89. 2009
    ..Therefore, correlates can be made between embryonic muscle development and postnatal regeneration...
  83. pmc An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans
    Barbara Meissner
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Genet 5:e1000537. 2009
    ..Many of the genes affecting sarcomere integrity have human homologs for which little or nothing is known...
  84. ncbi Muscle development in mdx mutant mice
    J Dangain
    Muscle Nerve 7:700-4. 1984
    ..This new mutant therefore presents an interesting case of muscle destruction and rapid regeneration. However, it is not an adequate model for Duchenne muscular dystrophy...
  85. pmc A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation
    Jong Sun Kang
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 182:497-507. 2008
    ..Furthermore, interaction with multiple scaffold-type proteins is a distinctive mode of cell surface receptor signaling and provides one mechanism for specificity of p38alpha/beta activation during cell differentiation...
  86. pmc Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex
    Martin Lange
    Group Cardiovascular Genetics, Department Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany
    Genes Dev 22:2370-84. 2008
    ..We present DPF3, a new epigenetic key factor for heart and muscle development characterized by a double PHD finger...
  87. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
    ..The result supports the long-held view that regulatory mutations are important for controlling phenotypic variation...
  88. ncbi Control of mitochondrial biogenesis during myogenesis
    C S Kraft
    Department of Biology, Queen s University, Kingston, ON, K7L 3N6, Canada
    Am J Physiol Cell Physiol 290:C1119-27. 2006
    ....
  89. ncbi A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development
    Ya Hsin Liu
    European Molecular Biology Laboratory, Heidelberg, Germany
    Dev Cell 16:280-91. 2009
    ..We show that this pathway is essential for somatic muscle development in Drosophila and for myotome morphogenesis in zebrafish...
  90. pmc IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis
    Nadine Bakkar
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 180:787-802. 2008
    ..Together, these data reveal a unique IKK/NF-kappaB signaling switch that functions to both inhibit differentiation and promote myotube homeostasis...
  91. ncbi MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis
    Hansol Lee
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Science 304:1675-8. 2004
    ..Moreover, Msx1 and H1b cooperate to inhibit muscle differentiation in cell culture and in Xenopus animal caps. Our findings define a previously unknown function for "linker" histones in gene-specific transcriptional regulation...
  92. ncbi Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo
    Monica Suelves
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
    Blood 99:2835-44. 2002
    ..Altogether, these studies demonstrate the requirement of plasmin during myogenesis in vitro and muscle regeneration in vivo...
  93. pmc JAK2/STAT2/STAT3 are required for myogenic differentiation
    Kepeng Wang
    Department of Biochemistry, Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China
    J Biol Chem 283:34029-36. 2008
    ..In summary, our current study reveals a novel role for the JAK2/STAT2/STAT3 pathway in myogenic differentiation...
  94. ncbi Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Dev Cell 16:810-21. 2009
    ..These findings identify novel genetic networks that may provide insights into myopathies which often affect only subsets of muscles...
  95. pmc Skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt nonmyogenic fates
    Jessica D Starkey
    Department of Molecular and Cell Biology, Center for Regenerative Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, Connecticut, USA
    J Histochem Cytochem 59:33-46. 2011
    ..The authors conclude that skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt an adipogenic fate...
  96. ncbi Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal
    Rana Abou-Khalil
    INSERM, U955, Creteil, France
    Cell Stem Cell 5:298-309. 2009
    ..We propose that Ang1/Tie-2 signaling regulates mpc self-renewal by controlling the return to quiescence of a subset of satellite cells...
  97. ncbi TGF-beta's delay skeletal muscle progenitor cell differentiation in an isoform-independent manner
    Elske J Schabort
    Department of Physiological Sciences, University of Stellenbosch, Private Bag X1, Stellenbosch 7602, South Africa
    Exp Cell Res 315:373-84. 2009
    ..These results demonstrate that TGF-beta promotes proliferation and delays differentiation of C2C12 myoblasts in an isoform-independent manner...
  98. ncbi Interactions of enolase isoforms with tubulin and microtubules during myogenesis
    A Keller
    Laboratoire CRRET, CNRS UMR 7149, Universite Paris 12, 94010 Creteil, France
    Biochim Biophys Acta 1770:919-26. 2007
    ..We suggest that the binding of enolase to microtubules could contribute to the regulation of the dynamism of the cytoskeletal filaments known to occur during the transition from myoblast to myotubes...
  99. ncbi Myogenic progenitor cells and skeletal myogenesis in vertebrates
    Margaret Buckingham
    Department of Developmental Biology, CNRS URA2578, Pasteur Institute, 25 rue du Docteur Roux, 75015 Paris Cedex, France
    Curr Opin Genet Dev 16:525-32. 2006
    ..New approaches that permit the grafting of purified satellite cells demonstrate their capacity for efficient muscle repair and for self-renewal. Regeneration in amphibians is now also shown to involve Pax-positive progenitor cells...
  100. pmc SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Development 137:755-65. 2010
    ..These findings uncover an essential role for Six1 in establishing a functionally normal ureter and provide new insights into the molecular basis of urinary tract malformations in BOR patients...
  101. pmc The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes
    Andrew Philp
    Neurobiology, Physiology and Behavior, University of California Davis, Davis, California 95616, USA
    Am J Physiol Regul Integr Comp Physiol 301:R864-72. 2011
    ..Collectively, our data show that PRC promotes skeletal muscle myogenesis and metabolism in vitro, thus identifying PRC as a functional skeletal muscle coactivator capable of regulating mitochondrial substrate utilization and respiration...

Research Grants75

  1. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..our proposal are, thus: 1) To define the role of SPL in muscle cell biology;2) To dissect the role of SPL in muscle development;and 3) To establish the role of SPL in muscle atrophy and regeneration...
  2. Maternal nutrient restriction and nonhuman primate fetal skeletal muscle developm
    Min Du; Fiscal Year: 2010
    ..Sheep and rat studies indicate that fetal nutrient deficiency affects fetal skeletal muscle development with long-lasting effects on adult skeletal muscle properties...
  3. Maternal Obesity affects AMP-Kinase in Muscle Cell Differentiation
    Min Du; Fiscal Year: 2013
    ..The objectives of proposed studies are to explore mechanisms associated with impairment of fetal skeletal muscle development due to maternal obesity...
  4. Pbx Homeodomain Proteins in Skeletal Muscle Differentiation
    LISA A MAVES; Fiscal Year: 2011
    ..differentiation of muscle precursor cells into contractile skeletal muscle fibers is necessary for normal muscle development and regeneration and, when defective, leads to musculoskeletal diseases such as muscular dystrophies and ..
  5. Mechanisms of Arsenic-Induced Developmental Toxicity
    Lisa Bain; Fiscal Year: 2009
    ..Our hypothesis is that inappropriate expression of transcription factors involved in skeletal muscle development, coupled with altered gene methylation, is a mechanism partly responsible for altered myogenesis and the ..
  6. A novel model for studying fetal skeletal muscle development
    Min Du; Fiscal Year: 2009
    ..Since there is no increase in muscle fiber number after birth, fetal stage is crucial for skeletal muscle development. Fetal muscle up to late gestation contains a large number of mesenchymal stem cells (pluripotent progenitor ..
  7. Mechanisms of Early Life Stress-Induced Endothelial Dysfunction
    Dao Ho; Fiscal Year: 2013
    ..HDACs play an important role in endothelial and vascular smooth muscle development. HDAC inhibition reduces vascular pathologies, but little is known of the role of specific HDACs in vascular ..
  8. Regulation and function of Six1 in zebrafish muscle development and in rhabdomyos
    JENEAN O'BRIEN; Fiscal Year: 2013
    ..Specific aims: 1) To investigate the six1a/b functions during zebrafish muscle development. 2) To determine whether miRs 30a, 219-3p and/or 216a regulate six1a/b during zebrafish myogenesis...
  9. Antisense oligonucleotide treatment for myotonic dystrophy
    Charles A Thornton; Fiscal Year: 2013
    ..No treatment is currently available that can improve the symptoms or slow the disease progression. The goal of this project is to develop a drug treatment for myotonic dystrophy. ..
  10. Deciphering the role of the RNA-binding protein, FXR1, in cardiac muscle assembly
    Carol C Gregorio; Fiscal Year: 2013
    ..for the function of Fragile X family members form the basis for our hypothesis that FXR1 regulates cardiac muscle development and function by controlling the localization, stability and/or translation of specific mRNA targets encoding ..
  11. ANALYSIS OF REPRODUCTIVE FUNCTION USING TRANSGENIC MICE
    Martin M Matzuk; Fiscal Year: 2013
    ..and subsequent embryo development in mice and women and that TGF2 and microRNA pathways are linked in smooth muscle development in the female reproductive tract...
  12. Genetic Analysis of Snail Superfamily Genes in Mice
    THOMAS HOOKER GRIDLEY; Fiscal Year: 2012
    ..are essential for Snai1 function in vivo;3) test the hypothesis that Snail family genes are important for muscle development, physiology and regeneration by determining the individual roles of the Snai1, Snai2 and Snai3 genes in ..
  13. IDENTIFICATION OF GENES ASSOCIATED WITH MYOBLAST FUSION
    Susan M Abmayr; Fiscal Year: 2012
    ..The process of muscle development requires recognition between different myoblasts and fusion of these cells to form muscle fibers...
  14. Understanding The Structural Basis of APOBEC Functions
    Xiaojiang S Chen; Fiscal Year: 2012
    ..role in somatic hypermutation for antibody maturation;APOBEC2 (Apo2) may play a regulatory role for heart muscle development;and Apo3 proteins, especially Apo3G, can restrict important viral pathogens, including Human ..
  15. Healthy Aging and Myostatin Antagonsits
    Wen Guo; Fiscal Year: 2012
    ..We hypothesize that blocking myostatin, an endogenous inhibitor for muscle development, at late middle age will increase muscle mass and delay sarcopenia...
  16. Using AKT1 and 2 and Rb1 to approach MyoD binding mechanisms genome-wide
    Sandra B Sharp; Fiscal Year: 2012
    ..understand the mechanisms governing DNA binding by transcription factor MyoD, which plays a defining role in muscle development. MyoD binding at numerous muscle-specific genes is facilitated by phosphorylation of the histone acetyl ..
  17. MicroRNA-29 in postnatal skeletal muscle development and disease
    JASON ROBERT O'ROURKE; Fiscal Year: 2012
    ..Although it is clear that skeletal muscle wasting is caused by defects in postnatal muscle development and maintenance, the precise molecular mechanisms controlling myogenesis after birth are poorly understood ..
  18. 2009 Insulin-like Growth Factors in Physiology and Disease Gordon Conference
    PETER S ROTWEIN; Fiscal Year: 2013
    ..cancer progression, and targeted therapeutics), cardiovascular biology (including control of vascular smooth muscle development and pathology, and regulation of myocardial hypertrophy), metabolic regulation (specifically signal ..
  19. Mechanism of Myosin Chaperone UNC-45: Structural, Functional &Genetic Approaches
    Sanford I Bernstein; Fiscal Year: 2013
    ..We will examine the roles of these proteins during muscle development and stress by RNAi-based transient knockdown in vivo...
  20. TAK1/TRAF6 Signaling in Skeletal Muscle
    Ashok Kumar; Fiscal Year: 2013
    ..cultured myoblasts;2) Investigate the role and cellular mechanisms by which TAK1 and TRAF6 regulate skeletal muscle development in vivo;and 3) Delineate the mechanisms by which TAK1 and TRAF6 regulates regeneration and atrophy in adult ..
  21. Investigating the Requirement of microRNAs in VEGF Signaling In Vivo.
    POLLONEAL OCBINA; Fiscal Year: 2012
    ..miR-1/206 is a muscle-specific miRNA and is responsible for the regulation of >54% target mRNAs during muscle development in zebrafish...
  22. The role of SIK1 in myogenic differentiation and skeletal muscle repair
    Rebecca L Berdeaux; Fiscal Year: 2013
    ..The second messenger cAMP and its cellular effectors are dynamically regulated during muscle development, but little is known about the specific targets of cAMP that mediates its effects in muscle cells...
  23. MEF2 Function in Cardiac Muscle Development
    Francisco J Naya; Fiscal Year: 2013
    ..The molecular dissection of MEF2 - dependent transcriptional pathways will be an important step in the development of genetic strategies to treat cardiovascular disease. ..
  24. INSULIN-LIKE GROWTH FACTORS AND MUSCLE DIFFERENTIATION
    PETER S ROTWEIN; Fiscal Year: 2012
    ..Insulin-like growth factors (IGFs) play key roles in normal muscle development in the fetus, are important for coordinating muscle regeneration following injury in the adult, and are ..
  25. Molecular Mechanism of Akirin Function During Myogenesis
    SCOTT JAMES NOWAK; Fiscal Year: 2013
    ..Following embryonic muscle development, the specification and differentiation of myoblasts remains essential for the maintenance and regeneration ..
  26. Iron homeostasis in mammalian muscle
    Nancy Catherine Andrews; Fiscal Year: 2013
    ..observed in mice lacking Tfr1 in skeletal muscle, to understand how Tfr1 and iron transport contribute to muscle development, muscle iron homeostasis, mitochondrial biogenesis and regulation of energy metabolism...
  27. Genomic Analysis of Cis Regulatory Networks of Drosophila Muscle Development
    Leila Shokri; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Embryonic muscle development occurs through carefully orchestrated events that guide the progressive determination of each cell fate...
  28. RNA DOMINANCE IN HUMAN DISEASE
    MAURICE SCOTT SWANSON; Fiscal Year: 2013
    ..for factors involved in CDM pathogenesis, we discovered that Mbnl3 expression is restricted to embryonic muscle development and postnatal muscle regeneration...
  29. Mechanisms Underlying Muscle Development in Drosophila
    ERIKA RAE GEISBRECHT; Fiscal Year: 2013
    ..have proven instrumental in uncovering many proteins essential for MTJ assembly and function and muscle development as a whole...
  30. Skeletal Muscle Regeneration from Differentiating Embryonic Stem Cells
    Rita C R Perlingeiro; Fiscal Year: 2012
    ..Although this system has been available for more than two decades, studies on skeletal muscle development, until our recent work, had progressed no farther than documenting muscle marker gene expression...
  31. Muscle and neuromuscular junctions in spinal muscular atrophy
    CHARLOTTE JANE SUMNER; Fiscal Year: 2013
    ..We will test these hypotheses by: 1) establishing whether or not a defect of muscle development contributes to SMA by studying cultured SMA muscle cells and by rescuing SMN expression specifically in ..
  32. The Growth Hormone/IGF-1 Axis in Skeletal Muscle
    Thomas L Clemens; Fiscal Year: 2013
    ..Growth hormone (GH) has long been recognized as a critical anabolic factor required for normal muscle development and regeneration. GH treatment improves muscle strength and reduces body fat in humans and animals...
  33. Role of Hippo-YAP Pathway in Smooth Muscle Phenotypic Modulation
    Jiliang Zhou; Fiscal Year: 2013
    ..Then we will investigate the functional role of YAP in smooth muscle development in vivo by generating a smooth muscle-specific YAP knock-out mouse...
  34. THE ROLE OF CDO IN MYOGENIC DIFFERENTIATION
    Robert S Krauss; Fiscal Year: 2013
    ..Illumination of such mechanisms is important both for understanding fundamental aspects of muscle development and identification of potential therapeutic targets for muscle disease and atrophy...
  35. Molecular Mechanisms of Myoblast Fusion
    ELIZABETH HUI CHEN; Fiscal Year: 2013
    ..Myoblast fusion is not only important for skeletal muscle development, but also critical for satellite cell-based muscle regeneration...
  36. MOLECULAR REGULATORY MECHANISM OF TONGUE MORPHOGENESIS
    Yang Chai; Fiscal Year: 2013
    ..of the tongue in our daily life, we know very little about the regulatory mechanism of mammalian tongue muscle development. The long term goal of this project is to understand the molecular and cellular mechanisms that control ..
  37. The role of Sox6 in skeletal muscle fiber type differentiation
    Nobuko Hagiwara; Fiscal Year: 2012
    ..birth, an understanding of how slow and fast skeletal muscle fibers initially form during fetal skeletal muscle development is still limited...
  38. INTERDISCIPLINARY TRAINING PROGRAM IN MUSCLE BIOLOGY
    Martin F Schneider; Fiscal Year: 2013
    ..diversity of faculty backgrounds, the training offered ranges from the molecular biological determinants of muscle development and molecular aspects of structure and function of muscle proteins through cell biological aspects of muscle ..
  39. Role of Pitx2 in Muscle Development and Regeneration
    Chrissa Kioussi; Fiscal Year: 2011
    ..Thus, it is of a great need to better understand the molecular mechanisms regulating vertebrate muscle development and regeneration...
  40. Myosin Isoforms in Urinary Bladder Function
    Muthu Periasamy; Fiscal Year: 2010
    ..major goals of the current proposal are to study how loss of SM2 myosin affects 1) urinary bladder smooth muscle development and maturation in male and female mice, 2) myosin filament structure and distribution within the bladder ..
  41. Genetic Variation of Muscle Mass
    DAVID ARTHUR BLIZARD; Fiscal Year: 2013
    ..Elucidation of the genetic architecture will lead to identification of biological pathways governing muscle development and/or maintenance, which can be used as pharmaceutical targets for prevention of muscle loss due to ..
  42. Role of LEK and Rb Protein Interactions in Heart and Skeletal Muscle Development
    MARY ELLEN DEES; Fiscal Year: 2013
    ..This can direct future therapy, such as stem cell therapy, to someday correct congenital defects at their origin and even stimulate damaged cardiac muscle to heal after injury such as myocardial infarction. ..
  43. LTQ Orbitrap Velos Mass Spectrometer with ETD
    Marc J Glucksman; Fiscal Year: 2012
    ..capabilities afforded by the Orbitrap Velos ETD to assist studies of infectious diseases, cocaine addiction, muscle development, pulmonary insufficiency, neural cell signaling, nuclear cell biology and structural biology, with adjunct ..
  44. Characterizing the Molecular Pathways of Bladder Smooth Muscle Development
    Kristin R Desouza; Fiscal Year: 2012
    ..long-term objective of this project is to characterize the molecular pathways responsible for bladder smooth muscle development, function, and pathogenesis...
  45. GENETIC REGULATION OF MUSCLE FIBER DIVERSITY
    RICHARD MATTHEW CRIPPS; Fiscal Year: 2013
    ..we have begun to define in detail how the regulatory factor Myocyte enhancer factor-2 (MEF2) controls muscle development in the Drosophila adult...
  46. Gating mechanism of TRPCs and Orai1 by STIM1 & their role in cardiac hypertrophy
    Joseph P Yuan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ca^"^ signaling mediates cardiac and smooth muscle development and proliferation...
  47. Development, Function and Repair of the Muscle Cell
    Mary K Baylies; Fiscal Year: 2012
    ..conference is timely and significant for three reasons: 1) the studies of embryonic and adult myogenesis and muscle development and regeneration are seeing a rich convergence in genes and mechanisms...
  48. Mechanisms underlying Paxillin-mediated amelioration of muscle degeneration
    Clarissa A Henry; Fiscal Year: 2013
    ..We have shown that NAD+ biosynthesis is necessary for muscle development and sufficient to correct dystrophic phenotypes in zebrafish...
  49. The Role of Germline Mutations in the Ras/MAPK Pathway on Skeletal Myogenesis
    KATHERINE ANNA RAUEN; Fiscal Year: 2013
    ..signaling disrupts both early myogenesis by inhibiting myoblast differentiation, and later stages of muscle development following differentiation, by inhibiting muscle growth...
  50. Functional Conservation of Myogenic Regulatory Factors
    Thomas H Meedel; Fiscal Year: 2010
    ..to humans, and are typically active only in muscle or muscle precursor cells where they play key roles in muscle development. MRF genes have also been shown to be involved in muscle repair and regeneration following injury or disuse, ..
  51. Role of microRNA-206 in skeletal muscle regeneration
    DOUGLAS PAUL MILLAY; Fiscal Year: 2012
    ..and inhibiting mRNA translation, function in the stress response of muscle cells and play important roles in muscle development and disease...
  52. RGS12 as a MAPK Scaffold in Muscle Development and Disease
    EMILY ANNE OESTREICH; Fiscal Year: 2012
    ..We also hope to highlight the RGS12 scaffold as a point of therapeutic intervention in metastatic rhabdomyosarcoma, a satellite cell-derived cancer where H-Ras mutations and increased ERK activity have been described. ..
  53. Regulation of glycolytic muscle metabolism
    Jiandie D Lin; Fiscal Year: 2013
    ..Successful completion of this project will provide novel insights into the mechanistic basis of glycolytic muscle development and plasticity, and shift the current paradigm on interrelationship between muscle fiber types and the ..
  54. Regulation of Muscle Regeneration by MicroRNAs
    Yongxin Chen; Fiscal Year: 2010
    ..are important in post-transcriptional gene silencing and involved in many biological processes including muscle development. The short-term objective of this application is to identify miRNAs which regulate myogenic progenitor cell (..
  55. Gating mechanism of TRPCs and Orai1 by STIM1 &their role in cardiac hypertrophy
    Joseph P Yuan; Fiscal Year: 2013
    Ca^* signaling mediates cardiac and smooth muscle development and proliferation...
  56. 2013 Myogenesis Gordon Research Conference and Gordon Research Seminar
    Gabrielle Kardon; Fiscal Year: 2013
    ..goal of the conference and seminar is to increase our understanding of the fundamental mechanisms of normal muscle development, growth and hypertrophy, regeneration, homeostasis and aging, cancer and myopathies, and evolution with an ..
  57. Dissection of the Salm Mediated Transcriptional Switch to Fibrillar Myogenesis
    Maria L Spletter; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Muscle development proceeds through an evolutionarily conserved series of events, including myoblast generation and migration, myotube formation and attachment to tendons, sarcomerogenesis and ..
  58. "Mechanisms underlying nicotine induced neuronal toxicity in zebrafish"
    Kurt R Svoboda; Fiscal Year: 2011
    ..all of the zebrafish nAChRs, 2) to determine the consequences of nicotine exposure on motoneuron and muscle development at the mechanistic level, 3) to determine the consequences of nicotine exposure on embryonic sensory neuron ..
  59. Predicting Protein-DNA Interactions with Structural Models
    Philip Bradley; Fiscal Year: 2013
    ..This protein, MyoD, has been called a 'master-regulator'of skeletal muscle development for its remarkable ability to turn cells of a variety of types into muscle cells...
  60. LINEAGE DETERMINATION IN MUSCLE
    Stephen J Tapscott; Fiscal Year: 2013
    ..Aim 3 will test the hypothesis that Myf5 has an epigenetic role in mouse muscle development but requires the transcriptional activity of MyoD, Myogenin, or MRF4 for myogenic differentiation of primary ..
  61. INHIBITION OF NONERYTHROID SPECTRIN BY ANTISENSE RNA
    Randall Moon; Fiscal Year: 1993
    ..Our approach is to use antisense RNA techniques to cause defects in alpha-fodrin during muscle development in the frog Xenopus laevis...
  62. Role of pre-mRNA alternative splicing programs in heart and muscle development
    ANDREA NICOLE LADD; Fiscal Year: 2013
    ..Furthermore, these studies will shed light on how disruption of normal alternative splicing contributes to disease states resulting from developmental perturbation ..
  63. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2013
    ..Knowledge gained in these studies will contribute to the molecular understanding of skeletal muscle development, repair, regeneration and hypertrophy...
  64. Utilization of a motility mutant to elucidate myotome formation in zebrafish
    Ethan Carver; Fiscal Year: 2009
    ..overall goal of this proposal is to gain a better understanding of the developmental processes involved in muscle development, while providing a dynamic learning environment for undergraduate students...
  65. GENE EXPRESSION DURING DROSOPHILA MYOGENESIS
    Allen Shearn; Fiscal Year: 1999
    We propose to continue systematic molecular genetic investigation of Drosophila muscle development and pathology, the broader goal being enhanced understanding of myopathies afflicting humans and domestic animals...
  66. REGULATORY ELEMENTS CONTROLLING TROPONIN I EXPRESSION
    STEPHEN KONIECZNY; Fiscal Year: 1993
    Skeletal muscle development involves the withdrawal of myogenic stem cells from the cell cycle, the formation of multinucleated muscle fibers and the coordinate accumulation of the contractile proteins including alpha-actin, myosin heavy ..
  67. SKI PROTO-ONCOGENE FAMILY IN EARLY DEVELOPMENT
    Sonia Pearson White; Fiscal Year: 1992
    ..Members of the ski family of genes, ski and sno, are expressed during skeletal muscle development, in determined myoblasts and in differentiated myofibers, and at lower levels in adult muscle...
  68. Molecular genetic analysis of UNC-82 kinase function in C. elegans muscle
    Pamela E Hoppe; Fiscal Year: 2010
    ..Both ARK5 and SNARK are expressed in striated muscle, but the role that either plays in muscle development or physiology is unknown...
  69. MYOSIN ISOFORMS--FIBER TYPES AND THYROID REGULATION
    GARY RADICE; Fiscal Year: 1992
    ..For this reason, the role of growth factors and of determining genes in muscle development is well under way in amphibians...
  70. Myofilament Protein Isoforms in Neuromuscular Reflex
    Jian Ping Jin; Fiscal Year: 2005
    ..The regulation of intrafusal myofilament protein isoform expression during muscle development, adaptation and diseases is largely unknown...
  71. KINASE FUNCTION DURING C ELEGANS MUSCLE DEVELOPMENT
    Benjamin Williams; Fiscal Year: 2004
    ..Existing pat-4 mutants will be used to directly investigate ILK function during muscle development in vivo. Specific aims: 1...
  72. Regulation of Myofibrillogenesis by Calcium Signaling
    Michael Ferrari; Fiscal Year: 2004
    ..APPLICANT): Spontaneous intracellular calcium elevations, called transients, occur during embryonic skeletal muscle development. Transients are necessary for myofibrillogenesis (MFG), the process of contractile protein assembly in ..
  73. TELOKIN GENE REGULATION IN SMOOTH MUSCLE
    BRIAN HERRING; Fiscal Year: 2005
    ..Unraveling these mechanisms is crucial to our understanding of smooth muscle development and of the pathology of many different vascular, pulmonary, intestinal and urogenital diseases that are ..
  74. NERVE-MUSCLE INTERACTIONS DURING JAW MUSCLE DEVELOPMENT
    CHARLES WIDMER; Fiscal Year: 2002
    ..However, much research has concentrated on the role of nerve-muscle interactions in limb muscle development. Previous studies in the limb have determined that motoneurons and the muscles they innervate are dependent ..
  75. CREATINE KINASE CONTROL ELEMENTS & CARDIAC DETERMINATION
    STEPHEN HAUSCHKA; Fiscal Year: 1992
    The long-term objectives of this project are to understand the molecular mechanisms which control heart muscle development and gene expression...