bone development

Summary

Summary: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.

Top Publications

  1. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
  2. ncbi Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    F Otto
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    Cell 89:765-71. 1997
  3. ncbi Developmental regulation of the growth plate
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Nature 423:332-6. 2003
  4. ncbi Reaching a genetic and molecular understanding of skeletal development
    Gerard Karsenty
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 2:389-406. 2002
  5. ncbi Control of osteoblast function and regulation of bone mass
    Shun ichi Harada
    Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19002, USA
    Nature 423:349-55. 2003
  6. ncbi Transforming growth factor-beta1 to the bone
    Katrien Janssens
    Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, 2610 Antwerp, Belgium
    Endocr Rev 26:743-74. 2005
  7. ncbi Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    A Vortkamp
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 273:613-22. 1996
  8. ncbi Endochondral ossification: how cartilage is converted into bone in the developing skeleton
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:46-62. 2008
  9. ncbi Tracking of activity and sedentary behaviors in childhood: the Iowa Bone Development Study
    Kathleen F Janz
    Department of Health and Sport Studies, University of Iowa, Iowa City, 52242, USA
    Am J Prev Med 29:171-8. 2005
  10. ncbi Bone development
    B R Olsen
    Harvard Medical School, Department of Cell Biology, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 16:191-220. 2000

Detail Information

Publications267 found, 100 shown here

  1. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
    ....
  2. ncbi Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    F Otto
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    Cell 89:765-71. 1997
    ..Thus, the Cbfa1 gene is essential for osteoblast differentiation and bone formation, and the Cbfa1 heterozygous mouse is a paradigm for a human skeletal disorder...
  3. ncbi Developmental regulation of the growth plate
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Nature 423:332-6. 2003
    ..The past few years have seen an enormous increase in understanding of the signalling pathways and the transcription factors that control endochondral bone development.
  4. ncbi Reaching a genetic and molecular understanding of skeletal development
    Gerard Karsenty
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 2:389-406. 2002
    ..This review addresses the role of the principal growth factors and transcription factors affecting these different processes and presents, in several cases, the genetic cascade leading to cell differentiation...
  5. ncbi Control of osteoblast function and regulation of bone mass
    Shun ichi Harada
    Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19002, USA
    Nature 423:349-55. 2003
    ..Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course...
  6. ncbi Transforming growth factor-beta1 to the bone
    Katrien Janssens
    Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, 2610 Antwerp, Belgium
    Endocr Rev 26:743-74. 2005
    ..This review provides an overall picture of the bone-specific actions of TGF-beta1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine...
  7. ncbi Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    A Vortkamp
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 273:613-22. 1996
    ....
  8. ncbi Endochondral ossification: how cartilage is converted into bone in the developing skeleton
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:46-62. 2008
    ..This review, which places an emphasis on recent advances and current areas of debate, discusses the complex interactions between cell types and signalling pathways that govern endochondral ossification...
  9. ncbi Tracking of activity and sedentary behaviors in childhood: the Iowa Bone Development Study
    Kathleen F Janz
    Department of Health and Sport Studies, University of Iowa, Iowa City, 52242, USA
    Am J Prev Med 29:171-8. 2005
    ..This study examined the tracking of activity and sedentary behavior in relation to adiposity during middle childhood...
  10. ncbi Bone development
    B R Olsen
    Harvard Medical School, Department of Cell Biology, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 16:191-220. 2000
    ....
  11. ncbi Regulation of bone development and extracellular matrix protein genes by RUNX2
    Toshihisa Komori
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Cell Tissue Res 339:189-95. 2010
    ..During bone development, RUNX2 induces osteoblast differentiation and increases the number of immature osteoblasts, which form ..
  12. ncbi PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth
    B Lanske
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 273:663-6. 1996
    ..These results suggest that the PTH/PTHrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation...
  13. pmc Dose-dependent effects of Runx2 on bone development
    Shiqin Zhang
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Bone Miner Res 24:1889-904. 2009
    ..gene structure permits temporal and spatial adjustments in the amount of Runx2 isoforms necessary for optimal bone development. To evaluate the gene dose-dependent effect of Runx2 isoforms on bone development, we intercrossed selective ..
  14. ncbi BMP2 signaling in bone development and repair
    Vicki Rosen
    Department of Developmental Biology, Harvard University School of Dental Medicine, Boston, MA 02115, USA
    Cytokine Growth Factor Rev 20:475-80. 2009
    ..This review summarizes current findings on the specific requirement for BMP2 in bone formation and repair...
  15. ncbi FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    David M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:1446-65. 2002
  16. pmc Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice
    Neil Charles Wallace Mackenzie
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Midlothian, Scotland, United Kingdom
    PLoS ONE 7:e32177. 2012
    ..We conclude that NPP1 is essential for normal bone development and control of physiological bone mineralization.
  17. ncbi Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily
    E E Storm
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305 5427
    Nature 368:639-43. 1994
    ..The highly specific skeletal alterations in bp and short ear mice suggest that different members of the BMP family control the formation of different morphological features in the mammalian skeleton...
  18. doi Paleontology. Sauropod gigantism
    P Martin Sander
    Division of Paleontology, Steinmann Institute, University of Bonn, D 53115 Bonn, Germany
    Science 322:200-1. 2008
  19. pmc Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones
    M T Engsig
    OSTEOPRO A S and Center for Clinical and Basic Research, DK 2750 Herlev Ballerup, Denmark
    J Cell Biol 151:879-89. 2000
    b>Bone development requires the recruitment of osteoclast precursors from surrounding mesenchyme, thereby allowing the key events of bone growth such as marrow cavity formation, capillary invasion, and matrix remodeling...
  20. ncbi Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning
    Deanna G Wilson
    Genentech, South San Francisco, CA 94080, USA
    Dev Biol 363:413-25. 2012
    ..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1...
  21. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
    Chondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates muscle and cardiovascular development, controls bone development by activating the gene ..
  22. ncbi Defective proteoglycan sulfation of the growth plate zones causes reduced chondrocyte proliferation via an altered Indian hedgehog signalling
    Benedetta Gualeni
    Department of Biochemistry Alessandro Castellani, University of Pavia, Pavia, Italy
    Matrix Biol 29:453-60. 2010
    ..These data suggest that in dtd mice proteoglycan undersulfation causes reduced chondrocyte proliferation in the proliferative zone via the Indian hedgehog pathway, therefore contributing to reduced long bone growth...
  23. pmc The role of Dickkopf-1 in bone development, homeostasis, and disease
    Joseph J Pinzone
    Department of Internal Medicine, The Ohio State University, Columbus, USA
    Blood 113:517-25. 2009
    Wnt/beta-catenin signaling is central to bone development and homeostasis in adulthood and its deregulation is associated with bone pathologies...
  24. ncbi Recent insights into the implication of nitric oxide in osteoblast differentiation and proliferation during bone development
    Marta Saura
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Alcala, Madrid, Spain
    ScientificWorldJournal 10:624-32. 2010
    ..During bone development, extracellular matrix remodeling is required for osteoblast differentiation and the process is largely ..
  25. ncbi Developmental plasticity in the life history of a prosauropod dinosaur
    P Martin Sander
    Institut für Paläontologie, Universitat Bonn, Nussallee 8, D 53115 Bonn, Germany
    Science 310:1800-2. 2005
    ..Individual life histories of P. engelhardti were influenced by environmental factors, as in modern ectothermic reptiles, but not in mammals, birds, or other dinosaurs...
  26. ncbi Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton
    C Hartmann
    Department of Genetics, Harvard Medical School, 02115, Boston, MA, USA
    Cell 104:341-51. 2001
    ..Induction of an ectopic joint-like region by Wnt-14 suppresses the formation of the immediately adjacent endogenous joint, potentially providing insight into the spacing of joints...
  27. ncbi Bone development and age-related bone loss in male C57BL/6J mice
    Virginia L Ferguson
    BioServe Space Technologies, University of Colorado, Boulder, CO 80309, USA
    Bone 33:387-98. 2003
    ..This study has thus demonstrated that the male C57BL/6J mouse is a novel and appropriate model for use in studying endogenous, aging-related osteopenia and may be a useful model for the study of Type II osteoporosis...
  28. ncbi Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse
    Yingli Wang
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Development 132:3537-48. 2005
    ..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype.
  29. ncbi Signaling networks in RUNX2-dependent bone development
    Toshihisa Komori
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    J Cell Biochem 112:750-5. 2011
    ..IHH is required for Runx2 expression in osteoprogenitor cells during endochondral bone development, and RUNX2 directly regulates Ihh expression in chondrocytes...
  30. ncbi Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005
    ....
  31. ncbi Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
    A R Hayman
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, UK
    Development 122:3151-62. 1996
    ....
  32. ncbi Physical activity and bone measures in young children: the Iowa bone development study
    K F Janz
    Department of Health, Leisure, and Sport Studies, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 107:1387-93. 2001
    Physical activity has a beneficial effect on bone development in circumpubertal children, although its effect on younger children is uncertain...
  33. ncbi Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis
    Elazar Zelzer
    Harvard Medical School, Department of Cell Biology, 240 Longwood Avenue, Boston, MA, USA
    Development 129:1893-904. 2002
    ..We also describe new in vivo evidence for a possible role of VEGF in chondrocyte maturation, and document that VEGF has a direct role in regulating osteoblastic activity based on in vivo evidence and organ culture experiments...
  34. ncbi Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation
    Sherrill L Adams
    Department of Biochemistry, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104 6030, USA
    J Cell Physiol 213:635-41. 2007
    ..The important features of each of these signaling pathways will be discussed as they relate to chondrocyte maturation, and a model will be proposed suggesting how these pathways may converge to regulate this process...
  35. ncbi Fatness, physical activity, and television viewing in children during the adiposity rebound period: the Iowa Bone Development Study
    Kathleen F Janz
    Department of Health and Sport Studies, 102 FH, The University of Iowa, Iowa City, IA 52242, USA
    Prev Med 35:563-71. 2002
    ..Activity was measured using accelerometry and parental report of children's television (TV) viewing. Dual energy X-ray absorptiometry was used to quantify body composition...
  36. pmc Maternal vitamin D status affects bone growth in early childhood--a prospective cohort study
    H T Viljakainen
    Hospital for Children and Adolescents, Helsinki University Central Hospital, Tukholmankatu 2C, PO Box 705, 00029 Helsinki, Finland
    Osteoporos Int 22:883-91. 2011
    ..Postnatal vitamin D supplementation improved vitamin D status but only partly eliminated the differences in bone variables induced by maternal vitamin D status during the fetal period...
  37. pmc Notch regulation of bone development and remodeling and related skeletal disorders
    Stefano Zanotti
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105, USA
    Calcif Tissue Int 90:69-75. 2012
    ..In conclusion, Notch is a regulator of skeletal development and bone remodeling, and abnormal Notch signaling is associated with developmental and postnatal skeletal disorders...
  38. pmc Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover
    Melita M Dvorak-Ewell
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, CA 94121, USA
    J Bone Miner Res 26:2935-47. 2011
    ..To discern the role of the osteoblast CaR in regulation of bone development and remodeling, we generated mice in which the CaR is excised in a broad population of osteoblasts expressing ..
  39. ncbi BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
    Kunikazu Tsuji
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Nat Genet 38:1424-9. 2006
    ..Collectively, our results identify BMP2 as an endogenous mediator necessary for fracture repair...
  40. pmc FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
    Norihiko Ohbayashi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo ku, Kyoto 606 8501, Japan
    Genes Dev 16:870-9. 2002
    ..Fgf18 is expressed in both osteogenic mesenchymal cells and differentiating osteoblasts during calvarial bone development. In addition, Fgf18 is expressed in the perichondrium and joints of developing long bones...
  41. ncbi A reaction-diffusion model for long bones growth
    D A Garzón-Alvarado
    Aragon Institute of Engineering Research, University of Zaragoza, Spain
    Biomech Model Mechanobiol 8:381-95. 2009
    b>Bone development is characterized by differentiation and growth of chondrocytes from the proliferation zone to the hypertrophying one...
  42. pmc Small body size and extreme cortical bone remodeling indicate phyletic dwarfism in Magyarosaurus dacus (Sauropoda: Titanosauria)
    Koen Stein
    Steinmann Institute Division of Paleontology, University of Bonn, 53115 Bonn, Germany
    Proc Natl Acad Sci U S A 107:9258-63. 2010
    ..The uniquely decreased growth rate and diminutive body size in Magyarosaurus were adaptations to life on a Cretaceous island and show that sauropod dinosaurs were not exempt from general ecological principles limiting body size...
  43. ncbi Can the growth factors PTHrP, Ihh and VEGF, together regulate the development of a long bone?
    J E M Brouwers
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Biomech 39:2774-82. 2006
    ..The three growth factors, PTHrP, Ihh and VEGF, could potentially together regulate tissue differentiation...
  44. ncbi Bone development: overview of bone cells and signaling
    Anna Teti
    Department of Experimental Medicine, University of L Aquila, Via Vetoio Coppito 2, 67100, L Aquila, Italy
    Curr Osteoporos Rep 9:264-73. 2011
    ..Herein I review landmark discoveries that shed light on the intricate mesh connecting bone cells among themselves and with other systems, thus representing the cellular basis of normal and abnormal bone development and homeostasis.
  45. ncbi MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
    K Holmbeck
    MMP Unit, National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA
    Cell 99:81-92. 1999
    ....
  46. pmc Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene cluster
    Kazuhiko Kawasaki
    Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 100:4060-5. 2003
    ..The order of duplication events may help delineate early events in mineralized skeletal formation, which is a major characteristic of vertebrates...
  47. pmc Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling
    Yukio Nakamura
    Clinical Research Center, Murayama Medical Center, Tokyo 208 0011, Japan
    Mol Cell Biol 31:3019-28. 2011
    ..Endochondral bone development is mildly advanced due to accelerated hypertrophic differentiation of chondrocytes in Mir140-null mice...
  48. ncbi Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation
    Yingzi Yang
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institute of Health, Bethesda, MD 20892, USA
    Development 130:1003-15. 2003
    ..We have studied the roles of two members of the Wnt family, Wnt5a and Wnt5b in long bone development. We show that Wnt5a is required for longitudinal skeletal outgrowth and that both Wnt5a and Wnt5b regulate ..
  49. pmc BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development
    Bing Shu
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Cell Sci 124:3428-40. 2011
    The BMP signaling pathway has a crucial role in chondrocyte proliferation and maturation during endochondral bone development. To investigate the specific function of the Bmp2 and Bmp4 genes in growth plate chondrocytes during cartilage ..
  50. ncbi Tyrannosaur life tables: an example of nonavian dinosaur population biology
    Gregory M Erickson
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Science 313:213-7. 2006
    ..Factors such as predation and entrance into the breeding population may have influenced tyrannosaur survivorship. This survivorship pattern can explain the rarity of juvenile specimens in museum collections...
  51. ncbi Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development
    Matthew J Hilton
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Development 132:4339-51. 2005
    ....
  52. pmc Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
    ..Their role in bone development was studied in mice expressing single isoforms...
  53. ncbi alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling
    Melanie Szweras
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 277:19991-7. 2002
    ..Our results demonstrate that ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis...
  54. pmc Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child
    Adrian Sayers
    Academic Rheumatology, Department of Clinical Science at North Bristol, University of Bristol, Bristol BS2 8HW, United Kingdom
    J Clin Endocrinol Metab 94:765-71. 2009
    ..Relationships between vitamin D exposure of the mother in pregnancy and skeletal development of the child are poorly understood...
  55. ncbi Cartilage tumours and bone development: molecular pathology and possible therapeutic targets
    Judith V M G Bovee
    Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Cancer 10:481-8. 2010
    ..benign lesions result from the deregulation of the hedgehog signalling pathway, which is involved in normal bone development. These lesions can be the precursors of malignant chondrosarcomas, which are notoriously resistant to ..
  56. ncbi Maternal vitamin D status determines bone variables in the newborn
    H T Viljakainen
    Department of Applied Chemistry and Microbiology, Division of Nutrition, P O Box 66, University of Helsinki, FI 00014 Helsinki, Finland
    J Clin Endocrinol Metab 95:1749-57. 2010
    ..Maternal vitamin D status may program neonatal skeletal development. The objective here was to determine the association of mothers' vitamin D status with bone variables of their newborns...
  57. ncbi Social position affects bone mass in childhood through opposing actions on height and weight
    Emma M Clark
    Community Based Medicine, University of Bristol, United Kingdom
    J Bone Miner Res 20:2082-9. 2005
    ..9 years. The tendency for social position to increase bone area and bone mass through a positive influence on height was opposed by a negative effect of social position on weight and fat mass...
  58. ncbi The IIIc alternative of Fgfr2 is a positive regulator of bone formation
    Vereragavan P Eswarakumar
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot Israel
    Development 129:3783-93. 2002
    ..This role contrasts with the negative role of Fgfr3, although recent reports implicate FGF18, a ligand for FGFR3IIIc and FGFR2IIIc, as a co-ordinator of osteogenesis via these two receptors...
  59. ncbi A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors
    P Tremblay
    Department of Neurology, University of California in San Francisco, San Francisco, California, 94143 0518, USA
    Dev Biol 203:49-61. 1998
    ..In addition, severe malformations were detected in the skeleton. The axial and appendicular skeleton displayed malformations and in particular multiple bone fusions...
  60. ncbi The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins
    S F Ahmed
    Developmental Endocrinology Research Group, Division of Developmental Medicine, Department of Child Health, Royal Hospital for Sick Children, University of Glasgow, Yorkhill, Glasgow G3 8SJ, UK
    J Endocrinol 206:249-59. 2010
    ..Chronic inflammation is associated with altered growth and skeletal development, and it is possible that SOCS proteins may have an important role to play in mediating these effects...
  61. ncbi The role of collagen in bone strength
    S Viguet-Carrin
    INSERM Research Unit 403 and Claude Bernard University, Lyon, France
    Osteoporos Int 17:319-36. 2006
    ..To illustrate the role of the crosslinking process of collagen in bone strength, clinical disorders associated with bone collagen abnormalities and bone fragility, such as osteogenesis imperfecta and osteoporosis, are described...
  62. pmc A Runx2 threshold for the cleidocranial dysplasia phenotype
    Yang Lou
    Department of Cell Biology, Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655 0106, USA
    Hum Mol Genet 18:556-68. 2009
    ..This mouse model allowed us to establish the minimal requirement of functional Runx2 for normal bone development. Runx2(neo7/neo7) mice have grossly normal skeletons with no abnormalities observed in the growth plate, but ..
  63. ncbi Periosteal bone formation--a neglected determinant of bone strength
    Ego Seeman
    Austin Hospital, University of Melbourne, Melbourne, Australia
    N Engl J Med 349:320-3. 2003
  64. ncbi Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth
    F Lupu
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Dev Biol 229:141-62. 2001
    ....
  65. ncbi Aging of microstructural compartments in human compact bone
    Ozan Akkus
    Department of Bioengineering, University of Toledo, Toledo, Ohio 43606 3390, USA
    J Bone Miner Res 18:1012-9. 2003
    ..Therefore, slowing of remodeling may lead to brittle bone tissue through accumulation of fully mineralized tissue fragments...
  66. ncbi Genetic ablation of Rac1 in cartilage results in chondrodysplasia
    Guoyan Wang
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Dev Biol 306:612-23. 2007
    ..In summary, these data identify a novel, essential and tissue-specific role of Rac1 in skeletal development and demonstrate that Rac1 deficiency affects numerous regulatory pathways in cartilage...
  67. ncbi Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling
    Colin Farquharson
    Division of Developmental Biology, The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK
    Pediatr Nephrol 28:547-56. 2013
    ..Therefore, in this review, we will focus on the premise that SOCS2 signaling represents a critical pathway in growth plate chondrocytes through which pro-inflammatory cytokines alter both GH/IGF-1 signaling and cellular function...
  68. pmc Transcriptional regulatory cascades in Runx2-dependent bone development
    Tong Ming Liu
    Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore
    Tissue Eng Part B Rev 19:254-63. 2013
    ..References are provided for more in-depth personal study...
  69. pmc A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development
    John Cobb
    Department of Zoology and Animal Biology and National Research Center Frontiers in Genetics, Sciences III, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Proc Natl Acad Sci U S A 103:4511-5. 2006
    ..Furthermore, using this mouse model, we establish the cellular etiology of these defects and show that Shox2 acts upstream the Runx2 gene, a key regulator of chondrogenesis...
  70. ncbi Physical activity and bone development during childhood and adolescence. Implications for the prevention of osteoporosis
    K Janz
    Department of Health, Leisure, and Sport Studies, University of Iowa, Iowa City, IA, USA
    Minerva Pediatr 54:93-104. 2002
    ..review, I examine the contribution of physical activity as an important behavioral determinant of children's bone development, particularly of peak bone mass...
  71. pmc Cell polarity: The missing link in skeletal morphogenesis?
    Sarah M Romereim
    Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA
    Organogenesis 7:217-28. 2011
    ..These findings position the limb as a key model to elucidate how global tissue patterning pathways direct local differences in cell behavior that, in turn, generate growth and form...
  72. ncbi Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification
    Cheng Lu
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China
    Bone 53:566-74. 2013
    ....
  73. ncbi Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification
    Takashi Miyazawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 143:3604-10. 2002
    ..This study provides in vivo and in vitro genetic evidence that cGKII plays a critical role in CNP-mediated endochondral ossification...
  74. ncbi Assessing a relationship between bone microstructure and growth rate: a fluorescent labelling study in the king penguin chick (Aptenodytes patagonicus)
    E de Margerie
    Adaptation et Evolution des Systèmes Ostéo Musculaires, FRE CNRS 2696, 2 place Jussieu, 75251 Paris Cedex 05, France
    J Exp Biol 207:869-79. 2004
    ..g. to fossil species). The biomechanical disadvantages of accelerated bone growth are discussed in relation to the locomotor behaviour of the chicks during their first month of life...
  75. ncbi Effects of targeted overexpression of pleiotrophin on postnatal bone development
    Rahul S Tare
    University Orthopaedics, Bone and Joint Research Group, University of Southampton, Southampton, UK
    Biochem Biophys Res Commun 298:324-32. 2002
    ..b>Bone development was investigated in ptn-overexpressing mice between 1 and 30 weeks...
  76. ncbi Additive protective effects of estrogen and androgen treatment on trabecular bone in ovariectomized rats
    Asa Tivesten
    Wallenberg Laboratory for Cardiovascular Research, Cardiovascular Institute at the Sahlgrenska Academy, Sahlgrenska University Hospital, Goteborg, Sweden
    J Bone Miner Res 19:1833-9. 2004
    ..This may in part be attributable to the effect of AR activation to attenuate the inhibitory effect of ER activation on bone formation...
  77. ncbi How does exercise affect bone development during growth?
    German Vicente-Rodriguez
    Department of Physical Education, University of Las Palmas de Gran Canaria, Canary Island, Spain
    Sports Med 36:561-9. 2006
    ....
  78. ncbi The axolotl limb: a model for bone development, regeneration and fracture healing
    Cara Hutchison
    Department of Biochemistry, Universite de Montreal, Quebec, Canada
    Bone 40:45-56. 2007
    ..These results suggest that the axolotl does not use the regeneration process to repair bone fractures...
  79. ncbi Fetal and postnatal bone development: reviewing the role of mechanical stimuli and nutrition
    Christof Land
    Children s Hospital, University of Cologne, Kerpener Strasse 62, D 50924 Cologne, Germany
    Best Pract Res Clin Endocrinol Metab 22:107-18. 2008
    Fetal and postnatal bone development is by tradition viewed as a process of bone mineral accretion or an increase in bone mass...
  80. ncbi The potential role of vascular endothelial growth factor (VEGF) in cartilage: how the angiogenic factor could be involved in the pathogenesis of osteoarthritis?
    M Murata
    Department of Bioregulation and Proteomics, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
    Osteoarthritis Cartilage 16:279-86. 2008
    ..is physiologically avascular tissue, angiogenesis can be observed during the process of endochondral bone development. Inflammation in articular joints can also lead to neovascularization in cartilage...
  81. pmc Developmental growth patterns of the filter-feeder pterosaur, Pterodaustro guiñazui
    A Chinsamy
    Zoology Department, University of Cape Town, Private Bag, Rondebosch 7701, Republic of South Africa
    Biol Lett 4:282-5. 2008
    ..Thereafter, growth continued for at least another 3-4 years at comparatively slower rates until larger adult body sizes were attained. Our analysis further provides definitive evidence that Pterodaustro had a determinate growth strategy...
  82. pmc Is there a critical period for bone response to weight-bearing exercise in children and adolescents? a systematic review
    K J MacKelvie
    School of Human Kinetics, University of British Columbia, 6081 University Boulevard, Vancouver, BC V6T 1Z1, Canada
    Br J Sports Med 36:250-7; discussion 257. 2002
    ..The effects of hormonal factors and growth on bone mineral change during puberty are examined, and the possibility of a critical period during which bone is especially adaptable to exercise is discussed...
  83. ncbi Effects of chemotherapy on bone metabolism and skeletal growth
    T Siebler
    University Children s Hospital, University of Leipzig, Germany
    Horm Res 58:80-5. 2002
    ....
  84. pmc Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
    Z Zhou
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 97:4052-7. 2000
    ..In tissues from null mice, activation of latent matrix metalloproteinase 2 was deficient, suggesting that MT1-MMP is essential for its activation in vivo...
  85. ncbi Folinic acid attenuates methotrexate chemotherapy-induced damages on bone growth mechanisms and pools of bone marrow stromal cells
    Cory J Xian
    Department of Orthopaedic Surgery, Women s and Children s Hospital, Adelaide, South Australia
    J Cell Physiol 214:777-85. 2008
    ....
  86. ncbi Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency
    Zenjiro Maruyama
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Dev Dyn 236:1876-90. 2007
    ..However, the functions of Runx2 in postnatal bone development remain to be clarified...
  87. ncbi The control of chondrogenesis
    Mary B Goldring
    Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute and Harvard Medical School, Boston, MA 02115, USA
    J Cell Biochem 97:33-44. 2006
    ..Recent work has revealed novel roles for mediators such as GADD45beta, transcription factors of the Dlx, bHLH, leucine zipper, and AP-1 families, and the Wnt/beta-catenin pathway that interact at different stages during chondrogenesis...
  88. pmc Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development
    M A Simpson
    Department of Medical Genetics, Clinical Developmental Sciences, St George s University of London, London, SW17 0RE, UK
    Am J Hum Genet 81:906-12. 2007
    ..This study defines the causative role of FAM20C in this lethal osteosclerotic disorder and its crucial role in normal bone development.
  89. ncbi Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development
    Hironori Hojo
    Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Bone Miner Metab 28:489-502. 2010
    ..We then discuss which factor would provide the most coherent evidence for its role in endochondral ossification...
  90. ncbi Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice
    Cheryl A Conover
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, College of Medicine Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    Endocrinology 152:2837-44. 2011
    ..In conclusion, tissue expression patterns and biological consequences of gene KO indicate distinct physiological roles for PAPP-A2 and PAPP-A in mice...
  91. ncbi Endochondral and intramembranous fetal bone development: osteoblastic cell proliferation, and expression of alkaline phosphatase, m-twist, and histone H4
    A Alborzi
    University of Connecticut Health Center, Farmington, USA
    J Craniofac Genet Dev Biol 16:94-106. 1996
    ..In both the hind foot and the mandible an overall decrease in labeling was observed during bone development. RNA samples from these tissues show increasing amounts of ALP mRNA, and decreasing amounts of histone H4 ..
  92. ncbi Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
    J Biomech 40:1333-9. 2007
    ..Ideally, such mechanical signals represent a non-pharmacologic means of controlling bone mass and morphology in spite of systemic pressures for bone resorption...
  93. ncbi Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes
    S Gack
    Forschungszentrum Karlsruhe, Institut fur Genetik, Germany
    Cell Growth Differ 6:759-67. 1995
    ..of interstitial collagenase to digest native collagen of types I, II, III, and X, the major components of bone, cartilage, and tendon, strongly suggests an important and specific function of this enzyme in bone development and remodeling.
  94. ncbi Bone morphogenetic proteins and their antagonists
    Elisabetta Gazzerro
    Unit of Muscular and Neurodegenerative Disorders, Gaslini Institute, Genoa, Italy
    Rev Endocr Metab Disord 7:51-65. 2006
    ..Both intracellular and extracellular antagonists are regulated by BMPs, indicating the existence of local feedback mechanisms to modulate BMP cellular activities...
  95. ncbi Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcriptionfactor gene
    H K Hong
    Department of Genetics BRB 721 and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106 4955, USA
    Hum Mol Genet 8:625-37. 1999
    ..We also localized a second member of this gene family ( Hfh1 ), a candidate for other developmental defects, approximately 470 kb proximal to Mf1...
  96. pmc Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling
    Christopher J Lengner
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Biol 172:909-21. 2006
    ..demonstrate that p53 plays a critical role in bone organogenesis and homeostasis by negatively regulating bone development and growth and by suppressing bone neoplasia and that Mdm2-mediated inhibition of p53 function is a ..
  97. pmc Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression
    Zhousheng Xiao
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 281:30884-95. 2006
    ..These findings are consistent with a possible functional role of cilia and PC1 in anabolic signaling in osteoblasts/osteocytes...
  98. ncbi The effect of chemotherapy on the morphology of the growth plate and metaphysis of the growing skeleton
    B L van Leeuwen
    Department of Surgical Oncology, Groningen University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Surg Oncol 29:49-58. 2003
    ..To establish the effect of three single chemotherapeutic agents on the growing skeleton, male Wistar rats were studied...
  99. pmc Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment
    Ke Wang
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Biol Chem 279:53848-56. 2004
    ..We have now determined the role of EGFR signaling in endochondral ossification. We analyzed long bone development in EGFR-deficient mice...
  100. ncbi Vanadium and bone development: putative signaling pathways
    D A Barrio
    Catedra de Bioquimica Patologica, Facultad de Ciencias Exactas, UNLP, 47 y 115 1900 La Plata, Argentina
    Can J Physiol Pharmacol 84:677-86. 2006
    ..This paper reviews the physiology of osteoblasts, the involvement of different growth factors on bone development, and the effects of vanadium derivatives on the skeletal system of animal models and bone-related cells...
  101. ncbi Bone microstructure and developmental plasticity in birds and other dinosaurs
    J Matthias Starck
    Institute of Systematic Zoology and Evolutionary Biology, University of Jena, Jena, Germany
    J Morphol 254:232-46. 2002
    ..We propose that such developmental plasticity in modern birds may be reduced in association with the shortened developmental time during the later evolution of the ornithurine birds...

Research Grants75

  1. CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERS
    Philip Osdoby; Fiscal Year: 2002
    Normal bone development and remodeling require complex humoral, cell- cell, and cell-matrix interactions...
  2. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ....
  3. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..of a novel endocrine regulatory loop through which insulin signaling in the osteoblast controls postnatal bone development and stimulates OC production, which in turn, regulates pancreatic insulin secretion...
  4. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ....
  5. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013
    ..We will also determine how the native bone protein spp24 (secreted phosphoprotein-24 kDa) inhibits BMP/TGF-b-dependent tumor cell growth. ..
  6. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..In addition, in vivo studies will be conducted to examine the ability of antioxidants to block EtOH-induced bone resorption. ..
  7. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2013
    ..gene expression, and mineralization in osteoblasts, that CaRs act at specific points temporally in bone development, and that CaR activation mediates its effects at least partly via the Wnt/[unreadable]-catenin pathway...
  8. Endothelin-1 and androgen in prostate cancer bone metastasis and bone health
    Gregory A Clines; Fiscal Year: 2013
    ..ET-1 plays a vital role in normal bone development and remodeling as well...
  9. Molecular &Cellular Effects of Human Mutations in Cytochrome P450 Reductase
    Satya Prakash Panda; Fiscal Year: 2013
    ..These cellular events, dependent on bone or liver metabolites, may affect bone development and hepatocyte function. Specific Aim III...
  10. CTGF promotes beta cell proliferation &revascularization in islet transplants
    Uma Gunasekaran; Fiscal Year: 2011
    ..Studies of bone development in CTGF homozygous null mutant mouse embryos have shown reduced angiogenesis at the growth plate...
  11. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..will test the hypothesis that 18 the mechanism and magnitude of bone loss in a mature animal is dependent on bone development. 19 Specifically, delayed pubertal onset will alter the architecture of bone that will affect the mechanism ..
  12. Vitamin D and fibroblast growth factor 23 physiology in adolescent girls
    DEBORAH MICHELLE MITCHELL; Fiscal Year: 2012
    ..FGF23) is a hormone which regulates phosphate and vitamin D metabolism;FGF23 may also be critical for normal bone development independent of its phosphate and vitamin D effects...
  13. Effect of Polybrominated Diphenal Ether Flame Retardant Exposure on Osteogenesis
    Deena J Small; Fiscal Year: 2010
    ..Disruptions in thyroid hormone function are associated with pathological conditions of bone development and remodeling including osteoporosis and it is possible that chronic PBDE exposure may be detrimental to ..
  14. CELLS PROCESSING HIGH DENSITY LIPOPROTEINS
    Salman Azhar; Fiscal Year: 2013
    ..Both bile acids and steroids are synthesized from SR-BI-mediated selectively delivered cholesterol, thus underscoring the relevance of understanding the cellular mechanisms controlling the functional expression of SR-BI. ..
  15. Role of Gsalpha in Regulating Osteoblast Differentiation
    JOY Y WU; Fiscal Year: 2012
    ..We have hypothesized that Gsa likely has essential functions at multiple stages of bone development and that ablation of Gsa early in the osteoblastic lineage will have profound effects on osteoblast ..
  16. The role of IFT80 in bone formation
    Shuying Yang; Fiscal Year: 2013
    ..The long term objective of this work is to understand the functionmechanism and interactions of IFT/cilia proteins in bone development and bone diseases.
  17. 3D Differentiation of Mesenchymal Stem Cells in Peptide Amphiphile Matrices
    John B Matson; Fiscal Year: 2011
    ..PA scaffolds developed and studied here may be used as injectable materials in conjunction with hMSCs for bone development in humans...
  18. Regulation of guanylyl cyclase A and B by hormones, ATP and phosphorylation
    Lincoln Ross Potter; Fiscal Year: 2013
    ....
  19. Histone Deacetylation Regulates Growth Plate Development
    Lei Wei; Fiscal Year: 2013
    ..The understanding of cell differentiation in growth plate may also be important to the understanding of abnormal chondrocyte differentiation in osteoarthritis. ..
  20. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..It successful, these studies will provide the basis for the rapid clinical development of VSELs for craniofacial osseous regeneration and treatment of a number of other skeletal based disorders. ..
  21. Effect of Smoking on Adult Stem Cell Differentiation
    Herman S Cheung; Fiscal Year: 2013
    ..Specific Aim 3: To evaluate the in vivo engraftment potential of the pluripotent human PDLSC. ..
  22. Nrf1 Molecular Pathway, Vitamin C Deficiency, and Spontaneous Fractures
    Subburaman Mohan; Fiscal Year: 2013
    ..Based on the published data that p53 blocks OB differentiation, Osx expression and bone development and our preliminary data that AA decreases p53 protein levels via PHD2-dependent mechanism, we will test a ..
  23. Effect of botulinum toxin plus vibration on bone in children with cerebral palsy
    Christopher M Modlesky; Fiscal Year: 2012
    ..The long-term goal is to optimize bone development and minimize short and long-term fracture incidence in children with disabilities...
  24. Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth &Biomechanics
    Marie Demay; Fiscal Year: 2013
    ....
  25. EBP50 Regulation of PTH Receptor in Bone
    Peter A Friedman; Fiscal Year: 2013
    ..Aim 3 will delineate the direct effects of EBP50 on bone to test the hypothesis that EBP50 regulates bone development and turnover...
  26. Synthesis of bone-selective osteogenic oxysterols
    Frank Stappenbeck; Fiscal Year: 2013
    ....
  27. Impact of Exercise on Body Composition in Premature Infants: New Approaches
    Dan M Cooper; Fiscal Year: 2013
    ..Should the positive effects of augmented exercise on body composition be supported, we would then anticipate widespread benefit in preventing long-term health consequences of prematurity at relatively low cost. ..
  28. Relationship between Hdac3 suppression and Wnt signaling in osteoblasts
    Meghan McGee-Lawrence; Fiscal Year: 2011
    ..in osteoblasts and binds to Runx2 to regulate osteoblastic gene expression, thus playing an important role in bone development and maintenance...
  29. Stem/progenitor cells of the chondrocyte and osteoblast lineage in vivo
    Noriaki Ono; Fiscal Year: 2013
    ..Diphtheria toxin will be administered at various times of development, and disruption on normal skeletogenesis will be monitored to elucidate the role of these progenitors in vivo. ..
  30. Delivery of Soluble FGFR3 as a Treatment for Achondroplasia
    Steven C Ghivizzani; Fiscal Year: 2013
    ..Affected children suffer from abnormal long bone development and deformations of the vertebrae and bones in the skull...
  31. ELUCIDATING THE FUNCTION OF MATRIPTASE-ACTIVATED PDGF D IN BONE METASTATIC PROSTA
    ABDO JAMAL NAJY; Fiscal Year: 2012
    ..Concomitantly, we envision our salient contributions leading to the development of novel and targeted therapeutics for prostate cancer in addition to improving the efficacy of existing treatment modalities. ..
  32. FGF SIGNALING IN SKELETAL DEVELOPMENT, HOMEOSTASIS AND AGING
    David M Ornitz; Fiscal Year: 2013
    ....
  33. Molecular regulation of renal 125(OH)2D production by Fibroblast Growth Factor23
    Farzana Perwad; Fiscal Year: 2010
    ..Understanding how various factors control vitamin D production will provide new therapeutic strategies to treat bone disease in children with rickets, and in patients suffering from kidney failure. ..
  34. Genetic Epidemiology of Osteosarcoma
    Logan G Spector; Fiscal Year: 2010
    ..Data concerning diet, physical activity, family health history, and anthropometries will also be collected through mailed surveys of parents and children. ..
  35. Role of Hypoxia in Differentiation
    Ernestina Schipani; Fiscal Year: 2012
    ..which is a major mediator of the cellular adaptation to hypoxia, controls critical steps of endochondral bone development. Our work thus far, in fact, suggests that the actions of Hif-1a are central to the regulation of survival ..
  36. Roles of MLL histone methyalses in estrogen mediated regulation of HDLR-SRB1
    Subhrangsu Mandal; Fiscal Year: 2010
    ..to their crucial roles in mediating hormonal effects in reproductive tissues, ERs play important roles in bone development, normal cardiovascular functions, cardiovascular disease (CVD), and in cancer...
  37. Mesenchymal Regulation of Jaw Bone Length
    Erin L Ealba; Fiscal Year: 2013
    ..Dr. Ealba is establishing herself as a young investigator in basic science research of craniofacial bone development. This K08 award will provide Dr...
  38. The Role of RAS/MAPK Signaling in Alveolar Process Development
    Amnon Sharir; Fiscal Year: 2013
    ..Using them as a model provides a unique opportunity to study the role of Ras signaling in craniofacial and bone development. CS is caused by a heterozygous de novo germline mutation in HRAS that results in a constitutively active Ras ..
  39. The Role of Leptin in Inflammation-driven Bone Loss
    Urszula T Iwaniec; Fiscal Year: 2013
    ..Finally, determining the precise role of leptin-modulated peripheral and central pathways is expected identify targets to prevent/treat inflammation-driven bone loss. ..
  40. Host MMP-mediated regulation of the vicious cycle of prostate to bone metastases
    Conor C Lynch; Fiscal Year: 2013
    ..abstract_text> ..
  41. Nell-1, A Cbfa 1 Downstream Target, In Bone Formation
    Kang Ting; Fiscal Year: 2009
    ..A better understanding of how and why Nell-1 works to form bone can accelerate the development of clinical therapies to help patients grow better and faster bone. ..
  42. Functional Analysis of NHA-oc/NHA2 in vivo
    RICARDO ANIBAL BATTAGLINO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Bone destruction by osteoclasts is essential for normal bone development. Osteoclast deficiency leads to osteopetrosis, which is characterized by increased bone mass and may lead to bone deformities ..
  43. EFFECTS OF ACID ON BONE
    David A Bushinsky; Fiscal Year: 2010
    ..We will determine the abundance and distribution of OGR1 at various stages of bone development and in primary neonatal calvarial osteoblasts and whether signaling via H+ activation of PSR(s) in ..
  44. Characterization of cranial dermal bone-specific miRNAs
    ARKHAT ABZHANOV; Fiscal Year: 2012
    ..We found evidence for an important role of microRNAs (miRNAs) in cranial intramembranous bone development and we hypothesize that these molecules will be important to understand craniofacial hard tissue ..
  45. PDGF D AND PROSTATE CANCER BONE METASTASIS
    Hyeong Reh Choi Kim; Fiscal Year: 2013
    ....
  46. Effect of Intense Multi-Modal Training on Bone Mineral Density, Bone Biomarkers,
    Todd Anthony Astorino; Fiscal Year: 2013
    ..Blood samples will be obtained at similar intervals to assess alterations in bone growth and resorption during training. Quality of life will be assessed to examine alterations in health outcomes in response to training. ..
  47. Role of a TGF-? Regulated Gene in Human and Mouse Osteoblasts and Skeleton
    Thomas C Spelsberg; Fiscal Year: 2013
    ..regulators of bone homeostasis in both men and women and since Wnt signaling is essential for normal bone development and maintenance...
  48. Cyclic nucleotide permeability of connexin mutants related to genetic disease
    Virginijus Valiunas; Fiscal Year: 2013
    ..The cyclic nucleotides, cAMP and cGMP are of particular interest as both are important in normal bone development and play a role in cardiac myocyte contractility and pacing...
  49. Shaping the craniofacial skeleton in the zebrafish
    APRIL F DELAURIER; Fiscal Year: 2010
    ..During endochondral and dermal bone development, cells differentiate, organize into condensations, then proliferate and rearrange to generate the distinct ..
  50. Identification of gene involved in late stage zebrafish craniofacial development
    REBECCA ANN ANDERSON; Fiscal Year: 2013
    ..genomic synteny with mammals;no gene within this critical region has previously been implicated in zebrafish bone development, suggesting the kol mutation may provide novel insight into craniofacial skeletogenesis...
  51. Consequences of Mutant COMP Expression and Therapeutic Approaches in Transgenic M
    Jacqueline T Hecht; Fiscal Year: 2013
    ..of mutant COMP (MT-COMP) in the endoplasmic reticulum (ER) which causes premature chondrocyte death during bone development. The focus of this research is to determine the cellular mechanism by which MT- COMP promotes the chondrocyte ..
  52. Molecular Mechanisms Underlying Tak1 Function in Osteoclasts
    Yousef Abu-Amer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bone development is tightly regulated by bone forming cells, osteoblasts, and bone resorbing cells, osteoclasts...
  53. The role of Spry2 in regulation of bone formation
    Ophir D Klein; Fiscal Year: 2012
    ..Knowledge about the molecular pathways controlling bone development and remodeling is thus of major clinical importance...
  54. The contribution of T cells to the anabolic activity of PTH in bone
    Jau Yi Li; Fiscal Year: 2013
    ..This proposal may reveal a novel relevant role of T cells in the anabolic activity of PTH in bone. ..
  55. MOLECULAR BASIS OF TOOTH ERUPTION
    Shaomian Yao; Fiscal Year: 2012
    ..abstract_text> ..
  56. The role of CTGF in bone cell development and function
    Steven N Popoff; Fiscal Year: 2012
    ..are expected to generate novel information regarding the effects of CTGF deficiency or over-expression on bone development in vivo, its mechanisms of action on osteoblasts and osteoclasts, and the molecular requirements for CTGF ..
  57. Fluoride &Other Factors in Childhood and Adolescent Bone Development
    Steven M Levy; Fiscal Year: 2013
    ..A number of gaps remain in our understanding of the effects of modifiable and non-modifiable factors on bone development during childhood and adolescence, and the impact of early bone health on the risk for common adult conditions ..
  58. The Mechanism of Excess Neural Crest-Derived Craniofacial Bone Formation in a Mou
    Fei Liu; Fiscal Year: 2012
    ..The pathways and mechanisms identified can be potentially utilized for the future novel treatment of bone lesions in TSC as well as osteoporosis patients. ..
  59. Obesity and bone development in young girls
    Scott B Going; Fiscal Year: 2013
    ..Obesity during adolescence, a critical time for bone development, likely has profound and lasting effects on bone strength and fracture risk...
  60. Cellular and Molecular Mechanisms of Patterned Growth of the Mammalian Skull
    Robert E Maxson; Fiscal Year: 2013
    ..In the long term, this work may help to devise new treatments of such birth defects. ..
  61. Regulation of osteoblast metabolism by Lrp5
    Ryan C Riddle; Fiscal Year: 2013
    ..While attempting to distinguish the contributions of Lrp5 to bone development from those attributable to the highly related Lrp6, our laboratory identified a previously unanticipated ..
  62. BIOGENESIS OF EXTRACELLULAR MATRIX
    Bjorn Reino Olsen; Fiscal Year: 2013
    ..The long-term goal of these studies is to understand cellular and molecular mechanisms that control bone development and homeostasis...
  63. Mesenchymal Regulation of Osteogenesis
    Richard A Schneider; Fiscal Year: 2013
    ..The goal of this project is to identify genes and embryonic events that control bone formation. ..
  64. Long-acting Growth Hormone for Treating HIV-Associated Adipose Redistribution Syn
    George Cox; Fiscal Year: 2009
    ....
  65. IN SITU POLYMERIZABLE GELS FOR DENTAL TISSUE ENGINEERING
    Antonios Mikos; Fiscal Year: 2002
    ....
  66. PHOSPHOLIPIDS AND MINERALIZATION OF OSTEOID
    David Howell; Fiscal Year: 1999
    ..With increased understanding of how growth plate calcification occurs, it is hoped that additional sites for therapeutic intervention in OA will be found. ..
  67. ROLE OF PHOSPHOLIPIDS IN MINERALIZATION OF OSTEOID
    David Howell; Fiscal Year: 1992
    ..With increased understanding of how growth plate calcification occurs, it is hoped that additional sites for therapeutic intervention in OA will be found...
  68. ENDOCHONDRAL BONE FORMATION IN RENAL FAILURE
    ISIDRO SALUSKY; Fiscal Year: 1999
    ..To determine the impact of chronic renal failure on endochondral bone development, selected molecular markers of chondrocyte differentiation will be evaluated in neonatal long bones implanted ..
  69. MECHANISMS OF BONE GROWTH IN FISH HYPEROSTOSIS
    Leslie Kaufman; Fiscal Year: 1992
    ..Aim 4: To test the hypothesis that fishes with FH bone will respond to seawater dilution by drawing upon mineral reserves at hyperostotic loci, while fishes without FH bone will lack this homeostatic capacity...
  70. BONE GROWTH, PERIOSTEAL MIGRATION AND MUSCLE FUNCTION
    Susan Herring; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  71. Improved Orthopedic Implant Surface Coatings
    Paul Hamilton; Fiscal Year: 2007
    ..2004) or a canine hip replacement model (Sumner, Turner et al. 2001). [unreadable] [unreadable] [unreadable]..
  72. MICROPHTHALMIA IN OSTEOCLAST DEVELOPMENT
    Katherine Weilbaecher; Fiscal Year: 2002
    ..Thus, osteoclast function lies at the crossroads of many human diseases of particular relevance in bone development and aging...
  73. BMP Receptor Signaling and Bone Remodeling
    Di Chen; Fiscal Year: 2005
    ..The underlying hypothesis is that BMP receptor signaling plays an essential role in bone formation during bone development, postnatal bone growth and adult bone remodeling...
  74. ENDOTHELIAL CELLS AND OSTEOCLAST DEVELOPMENT
    Patricia Collin Osdoby; Fiscal Year: 1999
    DESCRIPTION: (Adapted from the Investigator's Abstract) Bone development and remodeling depend on complex interactions between bone cells and other cells within the bone microenvironment...
  75. OSTEOCLASTIC PHOSPHOTYROSYL PHOSPHATASE AND RESORPTION
    KIN HING LAU; Fiscal Year: 2002
    ....