isometric contraction

Summary

Summary: Muscular contractions characterized by increase in tension without change in length.

Top Publications

  1. pmc In vivo human gastrocnemius architecture with changing joint angle at rest and during graded isometric contraction
    M V Narici
    Reparto di Fisiologia Istituto di Tecnologie Biomediche Avanzate, Consiglio Nazionale dell Ricerche, Milano, Italy
    J Physiol 496:287-97. 1996
  2. ncbi Task-dependent modulations of cortical oscillatory activity in human subjects during a bimanual precision grip task
    J M Kilner
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London, United Kingdom
    Neuroimage 18:67-73. 2003
  3. ncbi Discharge rate variability influences the variation in force fluctuations across the working range of a hand muscle
    Chet T Moritz
    Department of Physiology and Biophysics, Box 357290, University of Colorado, Boulder, USA
    J Neurophysiol 93:2449-59. 2005
  4. ncbi Human skeletal muscle structure and function preserved by vibration muscle exercise following 55 days of bed rest
    Dieter Blottner
    Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charite University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany
    Eur J Appl Physiol 97:261-71. 2006
  5. pmc Measurement of voluntary activation of fresh and fatigued human muscles using transcranial magnetic stimulation
    Gabrielle Todd
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney 2031, Australia
    J Physiol 551:661-71. 2003
  6. ncbi Mechanisms that contribute to differences in motor performance between young and old adults
    Roger M Enoka
    Department of Kinesiology and Applied Physiology University of Colorado, Boulder, CO 80309 0354, USA
    J Electromyogr Kinesiol 13:1-12. 2003
  7. ncbi Multiple features of motor-unit activity influence force fluctuations during isometric contractions
    Anna M Taylor
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309 0354, USA
    J Neurophysiol 90:1350-61. 2003
  8. pmc Removal of visual feedback alters muscle activity and reduces force variability during constant isometric contractions
    Harsimran S Baweja
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Exp Brain Res 197:35-47. 2009
  9. pmc Fluctuations in isometric muscle force can be described by one linear projection of low-frequency components of motor unit discharge rates
    Francesco Negro
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    J Physiol 587:5925-38. 2009
  10. ncbi Differences in quadriceps muscle strength and fatigue between lean and obese subjects
    Nicola A Maffiuletti
    Neuromuscular Research Laboratory, Schulthess Klinik, Lengghalde 2, 8008, Zurich, Switzerland
    Eur J Appl Physiol 101:51-9. 2007

Research Grants

  1. Role of Thromboxane in the Exercise Pressor Reflex in Peripheral Artery Disease
    ANNA KATHERINE LEAL; Fiscal Year: 2013
  2. EM STUDIES ON MUSCLE
    KENNETH ALLEN TAYLOR; Fiscal Year: 2013
  3. CREATINE IN AMYOTROPHIC LATERAL SCLEROSIS
    Jeffrey Rosenfeld; Fiscal Year: 2004
  4. NEUTRON DIFFRACTION STUDIES OF MUSCLE CONTRACTION
    ROBERT MENDELSON; Fiscal Year: 1993
  5. Improving transcapillary transport by reducing interstitial fluid pressure
    LEONARDO CARVALHO; Fiscal Year: 2009
  6. NEUROHORMONAL REGULATION OF COLONIC SMOOTH MUSCLE
    WILLIAM SNAPE; Fiscal Year: 1992
  7. IGF-I/ALS Trial
    Eric Sorenson; Fiscal Year: 2007
  8. CA++ SENSITIVITY IN STUNNED CARDIAC MYOCYTES
    MATTHEW WOLFF; Fiscal Year: 2000
  9. ROLE OF ENKEPHALINASE IN REGULATING AIRWAYS
    D Borson; Fiscal Year: 1991
  10. Mentored Patient Oriented Research Career Development
    Diana Escolar; Fiscal Year: 2005

Detail Information

Publications340 found, 100 shown here

  1. pmc In vivo human gastrocnemius architecture with changing joint angle at rest and during graded isometric contraction
    M V Narici
    Reparto di Fisiologia Istituto di Tecnologie Biomediche Avanzate, Consiglio Nazionale dell Ricerche, Milano, Italy
    J Physiol 496:287-97. 1996
    ..medialis architecture is significantly affected both by changes of joint angle at rest and by isometric contraction intensity...
  2. ncbi Task-dependent modulations of cortical oscillatory activity in human subjects during a bimanual precision grip task
    J M Kilner
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London, United Kingdom
    Neuroimage 18:67-73. 2003
    ....
  3. ncbi Discharge rate variability influences the variation in force fluctuations across the working range of a hand muscle
    Chet T Moritz
    Department of Physiology and Biophysics, Box 357290, University of Colorado, Boulder, USA
    J Neurophysiol 93:2449-59. 2005
    ..22) at all force levels. These results support the hypothesis that discharge rate variability is a major determinant of the trends in isometric force variability across the working range of a muscle...
  4. ncbi Human skeletal muscle structure and function preserved by vibration muscle exercise following 55 days of bed rest
    Dieter Blottner
    Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charite University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany
    Eur J Appl Physiol 97:261-71. 2006
    ..Daily short RVE should be employed as an effective atrophy countermeasure co-protocol preferentially addressing postural calf muscles during prolonged clinical immobilization or long-term human space missions...
  5. pmc Measurement of voluntary activation of fresh and fatigued human muscles using transcranial magnetic stimulation
    Gabrielle Todd
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney 2031, Australia
    J Physiol 551:661-71. 2003
    ....
  6. ncbi Mechanisms that contribute to differences in motor performance between young and old adults
    Roger M Enoka
    Department of Kinesiology and Applied Physiology University of Colorado, Boulder, CO 80309 0354, USA
    J Electromyogr Kinesiol 13:1-12. 2003
    ....
  7. ncbi Multiple features of motor-unit activity influence force fluctuations during isometric contractions
    Anna M Taylor
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309 0354, USA
    J Neurophysiol 90:1350-61. 2003
    ..The abduction force exerted by the index finger due to an isometric contraction of the first dorsal interosseus muscle was measured in 10 young adults...
  8. pmc Removal of visual feedback alters muscle activity and reduces force variability during constant isometric contractions
    Harsimran S Baweja
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Exp Brain Res 197:35-47. 2009
    ....
  9. pmc Fluctuations in isometric muscle force can be described by one linear projection of low-frequency components of motor unit discharge rates
    Francesco Negro
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    J Physiol 587:5925-38. 2009
    ..In conclusion, one signal captures most of the underlying variability of the low-frequency components of motor unit discharge rates and explains large part of the fluctuations in the motor output during isometric contractions...
  10. ncbi Differences in quadriceps muscle strength and fatigue between lean and obese subjects
    Nicola A Maffiuletti
    Neuromuscular Research Laboratory, Schulthess Klinik, Lengghalde 2, 8008, Zurich, Switzerland
    Eur J Appl Physiol 101:51-9. 2007
    ..The observed quadriceps muscle function impairments (voluntary fatigue and relative strength) probably contribute to the reduced functional capacity of obese subjects during daily living activities...
  11. ncbi A comparison of surface and intramuscular myoelectric signal classification
    Levi J Hargrove
    Institute of Biomedical Engineering, Department of Electrical and Computer Engineering, University of New Brunswick, P O Box 4400, Fredericton, NB E3B 5A3, Canada
    IEEE Trans Biomed Eng 54:847-53. 2007
    ..during which surface and intramuscular MES were collected simultaneously for 10 different classes of isometric contraction. There was no significant difference in classification accuracy as a result of using the intramuscular MES ..
  12. ncbi Voluntary activation of human knee extensors measured using transcranial magnetic stimulation
    S Goodall
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, UK
    Exp Physiol 94:995-1004. 2009
    ..5% between days. Voluntary activation was also determined immediately after a 2 min maximal voluntary isometric contraction; in four of these subjects, voluntary activation was determined 30 min after the sustained contraction...
  13. pmc Greater amount of visual information exacerbates force control in older adults during constant isometric contractions
    Deanna M Kennedy
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Exp Brain Res 213:351-61. 2011
    ..findings suggest that greater amount of visual information may be detrimental to the control of a constant isometric contraction in older adults, and this impairment may be due to their inability to effectively modulate the motor ..
  14. pmc A mathematical model of muscle containing heterogeneous half-sarcomeres exhibits residual force enhancement
    Stuart G Campbell
    Department of Physiology and the Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS Comput Biol 7:e1002156. 2011
    ....
  15. ncbi Passive hyperthermia reduces voluntary activation and isometric force production
    Shawnda Morrison
    Human Performance Laboratory, Faculty of Kinesiology, University of New Brunswick, Fredericton, NB, E3B 5A3, Canada
    Eur J Appl Physiol 91:729-36. 2004
    ..05). We conclude that an elevated T(c) reduces VA during isometric MVC, and neither T(sk) nor cardiovascular or psychophysical strain modulates this response. Results are given as mean (SD) unless otherwise stated...
  16. ncbi Interlimb and within limb force coordination in static bimanual manipulation task
    Slobodan Jaric
    Department of Health, Nutrition, and Exercise Sciences, Human Performance Lab, University of Delaware, 547 S College Av, Newark, DE 19716, USA
    Exp Brain Res 168:88-97. 2006
    ..However, the neural mechanisms that play a role in the revealed differences need further elucidation...
  17. ncbi Task goal and grip force dynamics
    Kimberlee Jordan
    Department of Kinesiology, 266 Recreation Building, The Pennsylvania State University, University Park, PA 16802, USA
    Exp Brain Res 156:451-7. 2004
    ..Theorizing about the organization of isometric force output should include the effects of task goals as well as the level of force per se...
  18. pmc The effect of bilateral isometric forces in different directions on motor cortical function in humans
    Juliette A Yedimenko
    CNBC Systems Neuroscience Institute, Department of Physical Medicine and Rehabilitation, 3501 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurophysiol 104:2922-31. 2010
    ..These findings suggest that during generation of bimanual isometric forces the M1 is driven by "extrinsic" parameters related to the hand action...
  19. ncbi Increased excitability and reduced intracortical inhibition in the ipsilateral primary motor cortex during a fine-motor manipulation task
    Takuya Morishita
    Human Motor Control Laboratory, Division of Human Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University, 1 7 1 Kagamiyama, Higashi hiroshima 739 8521, Japan
    Brain Res 1371:65-73. 2011
    ..The present findings suggest that the differences between the effects of the FM and pFM tasks on ipsi-M1 excitability were caused by their property...
  20. ncbi Reductions in resting blood pressure after 4 weeks of isometric exercise training
    Gavin R Devereux
    Department of Sport Science, Tourism and Leisure, Canterbury Christ Church University, North Holmes Road, Canterbury, CT1 1QU, UK
    Eur J Appl Physiol 109:601-6. 2010
    ..4 mmHg, respectively. No differences were observed in the other resting measures. In conclusion, this study has shown that it is possible to induce reductions in arterial blood pressure after 4 weeks of bilateral-leg isometric exercise...
  21. ncbi Variability of motor unit discharge and force fluctuations across a range of muscle forces in older adults
    Brian L Tracy
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80523 1582, USA
    Muscle Nerve 32:533-40. 2005
    ..These findings underscore the contribution of variability of motor unit activity to motor output in normal human aging...
  22. ncbi Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres
    Nicolas Place
    Institute of Movement Sciences and Sport Medicine, Faculte de Medecine, Universite de Geneve, Rue du conseil général 10, 1205, Geneve, Switzerland
    Eur J Appl Physiol 110:1-15. 2010
    ..We use fatigue-induced changes observed in intact single muscle fibres, where force and cellular Ca(2+) handling can be directly measured, to explain changes in E-C coupling observed in human muscle during exercise...
  23. ncbi Effect of graded hypoxia on supraspinal contributions to fatigue with unilateral knee-extensor contractions
    Stuart Goodall
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    J Appl Physiol (1985) 109:1842-51. 2010
    ....
  24. pmc Force enhancement following muscle stretch of electrically stimulated and voluntarily activated human adductor pollicis
    Hae Dong Lee
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada T2N 1N4
    J Physiol 545:321-30. 2002
    ....
  25. pmc Motor unit synchronisation is enhanced during slow lengthening contractions of a hand muscle
    John G Semmler
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder 80309 0354, USA
    J Physiol 545:681-95. 2002
    ..These data indicate that the timing of inputs received by the motoneurones innervating the first dorsal interosseus of young adults differs during postural, shortening and lengthening contractions against a light load...
  26. ncbi Beta-range EEG-EMG coherence with isometric compensation for increasing modulated low-level forces
    Vihren Chakarov
    Neurological Clinic, University Freiburg, Freiburg, Germany
    J Neurophysiol 102:1115-20. 2009
    ..This finding re-enforces the importance of the beta-range EEG-EMG coherence in sensorimotor integration...
  27. ncbi Hand-held dynamometry for muscle strength measurement in children with cerebral palsy
    Jodi Crompton
    Rehabilitation Sciences Research Centre, School of Physiotherapy, The University of Melbourne, Parkville, Victoria, 3108 Australia
    Dev Med Child Neurol 49:106-11. 2007
    ..A 'make' test, using a gradual build-up of force to a maximum isometric contraction, was employed and peak values were normalized to body weight for analyses...
  28. ncbi Effect of age on muscle functions investigated with surface electromyography
    Roberto Merletti
    Laboratorio di Ingegneria del Sistema Neuromuscolare, Dipartimento di Elettronica, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy
    Muscle Nerve 25:65-76. 2002
    ..Thus, changes in fiber type distribution and decrease in MU firing rate with aging may be factors determining the decrease in maximal voluntary contraction torque and in myoelectric manifestations of muscle fatigue...
  29. ncbi Trunk muscle recruitment patterns in patients with low back pain enhance the stability of the lumbar spine
    Jaap H van Dieen
    Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 28:834-41. 2003
    ..A comparative study of trunk muscle recruitment patterns in healthy control subjects and patients with chronic low back pain was conducted...
  30. ncbi Old adults exhibit greater motor output variability than young adults only during rapid discrete isometric contractions
    E A Christou
    University of Illinois at Urbana Champaign, USA
    J Gerontol A Biol Sci Med Sci 56:B524-32. 2001
    ..Results suggest that the control of force in active elderly people declines only during rapid discrete contractions and that this decline may be associated with declines in temporal characteristics of the force production...
  31. ncbi Aging and the time and frequency structure of force output variability
    David E Vaillancourt
    School of Kinesiology, University of Illinois at Chicago, Chicago, Illinois 60608, USA
    J Appl Physiol (1985) 94:903-12. 2003
    ..Neurobiol Aging 23: 1-11, 2002)...
  32. pmc Corticomuscular synchronization with small and large dynamic force output
    Agnieszka Andrykiewicz
    Neurological Clinic, University Freiburg, Breisacherstrasse 64, 79106 Freiburg, Germany
    BMC Neurosci 8:101. 2007
    ..The CMC, the cortical EEG spectral power (SP), the EMG SP and the errors in motor performance (as the difference between target and exerted force) were analyzed...
  33. ncbi Task-dependent oscillations during unimanual and bimanual movements in the human primary motor cortex and SMA studied with magnetoencephalography
    J Gross
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Neuroimage 26:91-8. 2005
    ..gamma band (26-40 Hz) showed strongest modulation for cerebro-muscular coherence and was strongest for the isometric contraction conditions...
  34. ncbi Force enhancement following stretching of skeletal muscle: a new mechanism
    W Herzog
    Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Exp Biol 205:1275-83. 2002
    ..Furthermore, the results indicate that mechanisms other than sarcomere length non-uniformity alone are operative...
  35. ncbi Neural adaptation to resistance training: changes in evoked V-wave and H-reflex responses
    Per Aagaard
    Department of Neurophysiology, Institute of Medical Physiology, Denmark
    J Appl Physiol (1985) 92:2309-18. 2002
    ..e., increased central motor drive, elevated motoneuron excitability, reduced presynaptic inhibition)...
  36. pmc Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids
    F Li
    Dept Dept of Respiratory Medicine, The Affiliated First People s Hospital of Shanghai, Jiao Tong University, Shanghai, China
    Eur Respir J 37:933-42. 2011
    ..p38 MAPK plays a role in maximal ACh-induced isometric contractile responses and increased contractility induced by ozone. Dexamethasone inhibits ACh-induced ASM contraction through phosphorylation of p38 MAPK and HSP27...
  37. ncbi Reduced muscle radiological density, cross-sectional area, and strength of major hip and knee muscles in 22 patients with hip osteoarthritis
    Anton Rasch
    Department of Orthopedics, Karolinska Institutet at Dandeyd Hospital, SE 182 88 Stockholm, Sweden
    Acta Orthop 78:505-10. 2007
    ..We hypothesized that substantial atrophy would manifest in multiple muscle groups along the affected limb, resulting in severe muscle dysfunction...
  38. ncbi Evidence for a supraspinal contribution to human muscle fatigue
    Janet L Taylor
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 33:400-5. 2006
    ..One factor that may contribute to supraspinal fatigue is the firing of fatigue-sensitive muscle afferents that may act to impair voluntary descending drive...
  39. ncbi Functional electrical stimulation improves motor recovery of the lower extremity and walking ability of subjects with first acute stroke: a randomized placebo-controlled trial
    Tiebin Yan
    Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
    Stroke 36:80-5. 2005
    ..The present study examines whether FES, given during acute stroke, was more effective in promoting motor recovery of the lower extremity and walking ability than standard rehabilitation alone...
  40. pmc Stiffness and fraction of Myosin motors responsible for active force in permeabilized muscle fibers from rabbit psoas
    Marco Linari
    Laboratorio di Fisiologia, Dipartimento di Biologia Animale e Genetica, Universita degli Studi di Firenze, Firenze, Italy
    Biophys J 92:2476-90. 2007
    ..The hs compliance is 43.0+/-0.8 nm MPa-1 in isometric contraction at saturating [Ca2+], whereas in rigor it is 28.2+/-1.1 nm MPa-1...
  41. ncbi Force and the motor cortex
    J Ashe
    Brain Sciences Center 11B, VAMC, Minneapolis, MN 55417, USA
    Behav Brain Res 87:255-69. 1997
    ..The relations between motor cortex activity and static or dynamic force are not invariant, but may be modified by the behavioral context of the motor output...
  42. pmc Quadriceps femoris muscle weakness and activation failure in patients with symptomatic knee osteoarthritis
    Michael D Lewek
    Department of Physical Therapy and Biomechanics and Movement Science Program, 301 McKinly Laboratory, University of Delaware, Newark, DE 19716, USA
    J Orthop Res 22:110-5. 2004
    ....
  43. ncbi Reliability and validity of the Biodex system 3 pro isokinetic dynamometer velocity, torque and position measurements
    Joshua M Drouin
    Department of Public Health, Georgia Southern University, PO Box 8076, Statesboro, GA 30460 8076, USA
    Eur J Appl Physiol 91:22-9. 2004
    ..With the exception of a systematic decrease in velocity at speeds of 300 degrees/s and higher, the Biodex System 3 performed with acceptable mechanical reliability and validity on all variables tested...
  44. pmc Stroke-related changes in neuromuscular fatigue of the hip flexors and functional implications
    Allison S Hyngstrom
    Departments of Physical Therapy, Marquette University, Milwaukee, Wisconsin, USA
    Am J Phys Med Rehabil 91:33-42. 2012
    ....
  45. ncbi Changes in muscle activation can prolong the endurance time of a submaximal isometric contraction in humans
    Sandra K Hunter
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309 0354, USA
    J Appl Physiol 94:108-18. 2003
    Fourteen young subjects (7 men and 7 women) performed a fatiguing isometric contraction with the elbow flexor muscles at 20% of maximal voluntary contraction (MVC) force on three occasions...
  46. ncbi Central and peripheral fatigue during passive and exercise-induced hyperthermia
    Julien D Périard
    ASPETAR, Research and Education Centre, Qatar Orthopaedic and Sports Medicine Hospital, Doha, Qatar
    Med Sci Sports Exerc 43:1657-65. 2011
    ..heating (PaH) to isolate the influence of exercise on neuromuscular function during a maximal voluntary isometric contraction (MVC) of the quadriceps under heat stress...
  47. ncbi System identification of the mechanomyogram from single motor units during voluntary isometric contraction
    Takanori Uchiyama
    Department of Applied Physics and Physico Informatics, Faculty of Science and Technology, Keio University, 3 14 1 Hiyoshi, Kohoku Ku, Yokohama, Japan
    Med Biol Eng Comput 49:1035-43. 2011
    A mechanomyogram (MMG) from single motor units of the anconeus muscle in voluntary isometric contraction was recorded from seven subjects using a spike-triggered averaging technique...
  48. ncbi Type 2 diabetes mellitus patients manifest characteristic spatial EMG potential distribution pattern during sustained isometric contraction
    Kohei Watanabe
    Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan Japan Society for the Promotion of Science JSPS, Kyoto, Japan
    Diabetes Res Clin Pract 97:468-73. 2012
    ..The purpose of the present study is to investigate spatial surface electromyography (SEMG) potential distribution pattern in type 2 diabetes mellitus (T2DM) patients...
  49. ncbi Effect of muscle model parameter scaling for isometric plantar flexion torque prediction
    Luciano Luporini Menegaldo
    Military Institute of Engineering, Department of Mechanical and Materials Engineering, Pça Gal Tibúrcio 80, 22280 270 Rio de Janeiro RJ, Brazil
    J Biomech 42:2597-601. 2009
    ..92+/-4.94% without scaling to 10.12+/-1.73%), which resulted mainly from the correction of the maximal muscle force parameter...
  50. pmc A kinetic model that explains the effect of inorganic phosphate on the mechanics and energetics of isometric contraction of fast skeletal muscle
    Marco Linari
    Dipartimento di Biologia Evoluzionistica, Laboratorio di Fisiologia, Universita di Firenze, Italy
    Proc Biol Sci 277:19-27. 2010
    ..of a new ATP molecule, is able to fit the [Pi] dependence of the force and number of myosin motors during isometric contraction of skeletal muscle...
  51. pmc 25(OH) vitamin D is associated with greater muscle strength in healthy men and women
    Adam S Grimaldi
    Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA
    Med Sci Sports Exerc 45:157-62. 2013
    ..The purpose of the study was to examine the relation between serum 25-hydroxy vitamin D (25(OH)D) levels and muscle strength in 419 healthy men and women over a broad age range (20-76 yr)...
  52. pmc Force-velocity properties of human skeletal muscle fibres: myosin heavy chain isoform and temperature dependence
    R Bottinelli
    Institute of Human Physiology, Pavia, Italy
    J Physiol 495:573-86. 1996
    ..Po/CSA was very temperature dependent in the 12-17 degrees C range, but less dependent between 17 and 22 degrees C...
  53. ncbi The effect of plyometric training on distance running performance
    Robert W Spurrs
    Human Movement Department, School of Leisure, Sport and Tourism, University of Technology, Sydney, PO Box 222, Lindfield NSW 2070, Australia
    Eur J Appl Physiol 89:1-7. 2003
    ..It is postulated that the increase in MTS resulted in improved RE. We speculate that the improved RE led to changes in 3-km running performance, as there were no corresponding alterations in VO(2max) or Th(la)...
  54. ncbi Analysis of force profile during a maximum voluntary isometric contraction task
    Elizabeth Househam
    Department of Neurology, 4th Floor, Queen Mary Wing, Royal London Hospital, Whitechapel, London E1 1BB, United Kingdom
    Muscle Nerve 29:401-8. 2004
    This study analyses maximum voluntary isometric contraction (MVIC) and its measurement by recording the force profile during maximal-effort, 7-s hand-grip contractions...
  55. pmc Attenuated fatigue in slow twitch skeletal muscle during isotonic exercise in rats with chronic heart failure
    Morten Munkvik
    Institute for Experimental Medical Research, Oslo University Hospital, Ulleval, Oslo, Norway
    PLoS ONE 6:e22695. 2011
    ..This observation is in striking contrast to previous reports which have employed isometric contractions to induce fatigue...
  56. ncbi Skeletal muscle contractility is preserved in COPD patients with normal fat-free mass
    H Degens
    Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Physiol Scand 184:235-42. 2005
    ..The muscle dysfunction may be caused by a loss of force-generating capacity, resulting from a loss of muscle mass, as well as by other alterations in contractile properties of skeletal muscle...
  57. pmc Reliability of maximal isometric knee strength testing with modified hand-held dynamometry in patients awaiting total knee arthroplasty: useful in research and individual patient settings? A reliability study
    Ian F H Koblbauer
    University of Applied Sciences, Amsterdam School of Health Professions, Amsterdam, The Netherlands
    BMC Musculoskelet Disord 12:249. 2011
    ..For these assessments, reliable measurements should be used. This study aimed to determine the inter- and intrarater reliability of hand-held dynamometry (HHD) in measuring isometric knee strength in patients awaiting TKA...
  58. pmc Modulation of interhemispheric inhibition by volitional motor activity: an ipsilateral silent period study
    Fabio Giovannelli
    Unit of Neurology, Florence Health Authority, Florence, Italy
    J Physiol 587:5393-410. 2009
    ..This phenomenon shows substantial topographical, temporal and neuronal circuit specificity, and has functional significance as it probably plays a pivotal role in suppressing mirror activity...
  59. ncbi Reliability of neuromuscular measurements during explosive isometric contractions, with special reference to electromyography normalization techniques
    Matthew W Buckthorpe
    School of Sport, Exercise, and Health Sciences, Loughborough University, Ashby Road, Loughborough, Leicestershire, LE11 3TU United Kingdom
    Muscle Nerve 46:566-76. 2012
    ..This study determined the between-session reliability of neuromuscular measurements during explosive isometric contractions, with special consideration of electromyography (EMG) normalization...
  60. ncbi A macroscopic ansatz to deduce the Hill relation
    Michael Gunther
    Eberhard Karls Universitat, Institut für Sportwissenschaft, Arbeitsbereich III, Wilhelmstrasse 124, D 72074 Tubingen, Deutschland, Germany
    J Theor Biol 263:407-18. 2010
    ..Moreover, this mechanical coupling internal to the muscle fibres may also be behind the macroscopic force dependency of the overall parallel damping coefficient...
  61. pmc Is the efficiency of mammalian (mouse) skeletal muscle temperature dependent?
    C J Barclay
    School of Physiotherapy and Exercise Science, Griffith University, Gold Coast, Queensland 4222, Australia
    J Physiol 588:3819-31. 2010
    ....
  62. ncbi Adaptations in the activation of human skeletal muscle induced by short-term isometric resistance training
    Christopher Del Balso
    Kinesiology and Health Science, Faculty of Science and Engineering, York University, Toronto, Ontario, Canada
    J Appl Physiol 103:402-11. 2007
    ..Augmentation of muscle activation may be due to increased volitional drive from supraspinal centers...
  63. ncbi Motor-unit coherence during isometric contractions is greater in a hand muscle of older adults
    John G Semmler
    School of Health Sciences, Deakin University, Burwood, 3125 Victoria, Australia
    J Neurophysiol 90:1346-9. 2003
    ....
  64. ncbi Individual-specific muscle maximum force estimation using ultrasound for ankle joint torque prediction using an EMG-driven Hill-type model
    Liliam Fernandes de Oliveira
    School of Physical Education and Sports, Federal University of Rio de Janeiro, Av Pau Brasil 540, Ilha do Fundao, Cidade Universitaria, 21941 590 Rio de Janeiro RJ, Brazil
    J Biomech 43:2816-21. 2010
    ..signals were obtained in a series of experiments carried out with 8 adult male subjects, who performed an isometric contraction protocol consisting of 10s step contractions at 20% and 60% of the maximum voluntary contraction level...
  65. ncbi Stretch-induced, steady-state force enhancement in single skeletal muscle fibers exceeds the isometric force at optimum fiber length
    Dilson E Rassier
    Faculty of Kinesiology, Human Performance Laboratory, University of Calgary, 2500, University Dr N W Calgary, AB T2N 1N4, Calgary, Canada
    J Biomech 36:1309-16. 2003
    ....
  66. ncbi Progressive suppression of intracortical inhibition during graded isometric contraction of a hand muscle is not influenced by hand preference
    Maryam Zoghi
    Discipline of Physiology and Research Centre for Human Movement Control, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, 5005, Australia
    Exp Brain Res 177:266-74. 2007
    ..If hemispheric differences in operation of M1 ICI circuits contribute to hand preference, a more challenging finger movement protocol may be needed to demonstrate this asymmetry...
  67. ncbi Synchronization of motor units in human soleus muscle during standing postural tasks
    G Mochizuki
    Graduate Program in Neuroscience, University of Western Ontario, 1201 Western Rd, Rm 1588, Elborn College, London, Ontario N6G 1H1, Canada
    J Neurophysiol 94:62-9. 2005
    ..The results of this study reveal that it is rather uncommon for bilateral soleus motoneurons to receive common descending synaptic inputs, whereas two motoneurons within a single soleus muscle do...
  68. pmc Corticospinal interaction during isometric compensation for modulated forces with different frequencies
    Jose R Naranjo
    Institute of Neuroinformatics, University of Zurich and ETH Zurich, Switzerland
    BMC Neurosci 11:157. 2010
    ..The effect of three frequencies of force modulation (0.6, 1.0 and 1.6 Hz) was tested. EEG, EMG from first dorsal interosseus, hand flexor and extensor muscles, and finger position were recorded in eight right-handed women...
  69. ncbi Force control and disease severity in Parkinson's disease
    Julie A Robichaud
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202, USA
    Mov Disord 20:441-50. 2005
    ..These measures provide objective quantification of the severity of motor impairment that can be used to investigate the efficacy of different interventions in individuals with PD...
  70. ncbi Effects of ageing on motor unit activation patterns and reflex sensitivity in dynamic movements
    J Kallio
    Neuromuscular Research Center, Department of Biology of Physical Activity, University of Jyvaskyla, Finland
    J Electromyogr Kinesiol 20:590-8. 2010
    ....
  71. ncbi The extensor tibiae muscle of the stick insect: biomechanical properties of an insect walking leg muscle
    Christoph Guschlbauer
    Zoological Institute, University of Cologne, Weyertal 119, 50923 Cologne, Germany
    J Exp Biol 210:1092-108. 2007
    ..hyperbola, but deviated from the hyperbolic shape in the region of maximum contraction force close to the isometric contraction. Step-like changes in muscle length induced by loaded release experiments characterised the non-linear ..
  72. pmc Recruitment and rate coding organisation for soleus motor units across entire range of voluntary isometric plantar flexions
    Tomomichi Oya
    University of Queensland, School of Human Movement Studies, Brisbane, QLD 4072, Australia
    J Physiol 587:4737-48. 2009
    ....
  73. ncbi Changes in masseter muscle blood flow during voluntary isometric contraction in humans
    Y Nakamura
    Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Oral Rehabil 32:545-51. 2005
    ..These findings indicate that blood flow in the masseter muscle during sustained isometric contraction is affected by the condition of contraction and may be influenced by the muscle region...
  74. ncbi The 1- to 2-Hz oscillations in muscle force are exacerbated by stress, especially in older adults
    Evangelos A Christou
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    J Appl Physiol (1985) 97:225-35. 2004
    ....
  75. ncbi The effects of electrode placement and innervation zone location on the electromyographic amplitude and mean power frequency versus isometric torque relationships for the vastus lateralis muscle
    Travis W Beck
    Department of Nutrition and Health Sciences, Human Performance Laboratory, 104K Ruth Leverton Hall, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    J Electromyogr Kinesiol 18:317-28. 2008
    ..In addition, absolute and relative (to femur length) estimates of IZ location for the VL resulted in similar inter-subject variability...
  76. pmc Residual force enhancement in myofibrils and sarcomeres
    V Joumaa
    University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada T2N 1N4
    Proc Biol Sci 275:1411-9. 2008
    ....
  77. ncbi Angle- and gender-specific quadriceps femoris muscle recruitment and knee extensor torque
    Danny M Pincivero
    Human Performance and Fatigue Laboratory, Department of Kinesiology, The University of Toledo, Mail Stop 201, Toledo, OH 43606, USA
    J Biomech 37:1689-97. 2004
    ..The findings demonstrate angle-, and gender-specific responses of knee extensor torque to maximal-effort contractions, while superficial QF muscle recruitment was most efficient at 90 degrees, and less dependent on gender...
  78. ncbi The role of passive structures in force enhancement of skeletal muscles following active stretch
    W Herzog
    Human Performance Laboratory, University of Calgary, 2500 University Drive, NW, Calgary, Canada AB T2N 1N4
    J Biomech 38:409-15. 2005
    ..Therefore, the passive force-length relationship is not a constant property of skeletal muscle, but depends critically on the muscle's contractile history...
  79. ncbi Uncertainty of knee joint muscle activity during knee joint torque exertion: the significance of controlling adjacent joint torque
    Daichi Nozaki
    Dept of Rehabilitation for Movement Functions, Research Institute NRCD, 4 1 Namiki, Tokorozawa, Saitama 359 8555, Japan
    J Appl Physiol (1985) 99:1093-103. 2005
    ....
  80. ncbi Force-time history effects in voluntary contractions of human tibialis anterior
    Markus Tilp
    Human Performance Laboratory, University of Calgary, 2500 University Drive NW, Calgary, AB, T2N 1N4, Canada
    Eur J Appl Physiol 106:159-66. 2009
    ..increased (residual force enhancement) or decreased (force depression), respectively compared to a purely isometric contraction. This behavior has been observed consistently from the single sarcomere to the whole muscle level...
  81. ncbi Reproducibility of cortex-muscle coherence
    Marjatta Pohja
    Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, PO Box 2200, FIN 02015 HUT, Espoo, Finland
    Neuroimage 26:764-70. 2005
    ..However, caution is needed when interpreting absolute levels or changes in the strength of coherence in single subjects between the sessions...
  82. ncbi Common input to motor neurons innervating the same and different compartments of the human extensor digitorum muscle
    Douglas A Keen
    Department of Physiology, University of Arizona, Tucson, Arizona 85721, USA
    J Neurophysiol 91:57-62. 2004
    ..4 +/- 0.22). Consequently, last-order synaptic projections are not distributed uniformly across the entire pool of motor neurons innervating ED but are segregated to supply subsets of motor neurons innervating different compartments...
  83. ncbi Considerations on the history dependence of muscle contraction
    Dilson E Rassier
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Appl Physiol 96:419-27. 2004
    ..Force depression after shortening and force enhancement after stretch are likely to have different origins...
  84. pmc Specific modulation of corticospinal and spinal excitabilities during maximal voluntary isometric, shortening and lengthening contractions in synergist muscles
    Julien Duclay
    Universite de Toulouse, UPS, PRISSMH, 118 route de Narbonne, Toulouse 31062, France
    J Physiol 589:2901-16. 2011
    ..The comparison of SOL and MG responses further suggests that the specific modulation of the corticospinal excitability during lengthening MVCs depends mainly on pre- and postsynaptic inhibitory mechanisms acting at the spinal level...
  85. ncbi Reliability of a new hand-held dynamometer in measuring shoulder range of motion and strength
    Angela Cadogan
    School of Rehabilitation and Occupation Studies, Faculty of Health and Environmental Sciences, AUT University, Private Bag 92006, Akoranga Drive, Northcote, Auckland 1142, New Zealand
    Man Ther 16:97-101. 2011
    ..84, and LOA ranged from 3.2 to 8.5 kg. Active ROM flexion demonstrated high levels of both intra- and interexaminer reliability. Measures of passive ROM and peak isometric force demonstrated acceptable levels of intraexaminer reliability...
  86. ncbi Aging, muscle fiber type, and contractile function in sprint-trained athletes
    Marko T Korhonen
    Dept of Health Sciences, University of Jyvaskyla, P O Box 35, FI 40014 Jyvaskyla, Finland
    J Appl Physiol 101:906-17. 2006
    ..Force-time characteristics of the knee extensors were determined by using isometric contraction. The cross-sectional area of type I fibers was unchanged with age, whereas that of type II fibers was ..
  87. ncbi Force enhancement following stretch in a single sarcomere
    T R Leonard
    Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
    Am J Physiol Cell Physiol 299:C1398-401. 2010
    ..Am J Physiol Cell Physiol 294: C74-C78, 2008; Labeit D et al., Proc Natl Acad Sci USA 100: 13716-13721, 2003), titin may regulate the sarcomeric force enhancement observed here...
  88. pmc Dynamic behaviour of half-sarcomeres during and after stretch in activated rabbit psoas myofibrils: sarcomere asymmetry but no 'sarcomere popping'
    I A Telley
    Laboratory for Biomechanics, ETH Zurich, ETH Honggerberg, HCI E 357 1, CH 8093 Zurich, Switzerland
    J Physiol 573:173-85. 2006
    ..In general, the half-sarcomere length changes (dynamics) before and after stretch were slow and the dynamics after stretch were not readily predictable on the basis of the steady-state force-sarcomere length relation...
  89. ncbi Corticospinal control of the thumb-index grip depends on precision of force control: a transcranial magnetic stimulation and functional magnetic resonance imagery study in humans
    M Bonnard
    Mediterranean Institute of Cognitive Neuroscience, UMR 6193, CNRS GLM, Universite d Aix Marseille, Marseille, France
    Eur J Neurosci 25:872-80. 2007
    ....
  90. ncbi Residual force enhancement after lengthening is present during submaximal plantar flexion and dorsiflexion actions in humans
    Gavin J Pinniger
    Muscle Contraction Group, Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Appl Physiol 102:18-25. 2007
    ..Although the underlying mechanisms are unclear, it appears that sarcomere popping and passive force enhancement are insufficient to explain the presence of RFE in these experiments...
  91. ncbi Effect of eccentric contraction velocity on muscle damage in repeated bouts of elbow flexor exercise
    Renato Barroso
    School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
    Appl Physiol Nutr Metab 35:534-40. 2010
    ..Changes in maximal voluntary isometric contraction strength, range of motion, muscle soreness, and plasma creatine kinase activity before and for 4 days ..
  92. ncbi Test-retest reliability of v-wave responses in the soleus and gastrocnemius medialis
    Gerd Marie Solstad
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Clin Neurophysiol 28:217-21. 2011
    ..82) and MVC force (0.98). This study provides novel evidence that V-wave responses can be consistently measured in the SOL and GM, thus advocating its continued use in future research...
  93. ncbi Resistance training: cortical, spinal, and motor unit adaptations
    Lisa Griffin
    Dept of Kinesiology and Health Education, University of Texas, Austin, TX 78712, USA
    Can J Appl Physiol 30:328-40. 2005
    ..Neural adaptations that occur during the ramp-up phase of isometric contraction include decreases in motor unit recruitment thresholds, increased motor unit discharge rates, and ..
  94. ncbi Early neural responses to strength training
    Victor S Selvanayagam
    School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia
    J Appl Physiol (1985) 111:367-75. 2011
    ....
  95. ncbi Estimation of elbow flexion force during isometric muscle contraction from mechanomyography and electromyography
    Wonkeun Youn
    School of Mechanical Aerospace and Systems Engineering Division of Mechanical Engineering, KAIST, Daejeon, Republic of Korea
    Med Biol Eng Comput 48:1149-57. 2010
    ..was to demonstrate the feasibility of MMG for estimating the elbow flexion force at the wrist under an isometric contraction by using an artificial neural network in comparison with EMG...
  96. ncbi Aging, visuomotor correction, and force fluctuations in large muscles
    Brian L Tracy
    Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523 1582, USA
    Med Sci Sports Exerc 39:469-79. 2007
    ..To determine the contribution of visuomotor correction to increased force fluctuations in the elbow flexor and knee extensor muscles of elderly adults...
  97. ncbi A predictive fatigue model--I: Predicting the effect of stimulation frequency and pattern on fatigue
    Jun Ding
    Interdisciplinary Graduate Program in Biomechanics and Movement Science, University of Delaware, Newark 19716, USA
    IEEE Trans Neural Syst Rehabil Eng 10:48-58. 2002
    ..The success of our current force- and fatigue-model system suggests its potential use in helping to identify the optimal activation pattern to use during the clinical application of functional electrical stimulation...
  98. ncbi The effects of isometric exercise training on resting blood pressure and orthostatic tolerance in humans
    Reuben Howden
    Physiology of Exercise, De Montfort University, Bedford, UK
    Exp Physiol 87:507-15. 2002
    ..Leg-training was accompanied by increases in estimated lean leg volume. The effects of isometric training on orthostatic tolerance appear to be specific to limbs that are directly involved in LBNP testing...
  99. ncbi Output of human motoneuron pools to corticospinal inputs during voluntary contractions
    P G Martin
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Neurophysiol 95:3512-8. 2006
    ..001). This suggests that motoneuron firing rates are important determinants of evoked output from the motoneuron pool. However, motor cortical output does not appear to be limited at high contraction strengths...
  100. ncbi Reproducible measurement of voluntary activation of human elbow flexors with motor cortical stimulation
    Gabrielle Todd
    Prince of Wales Medical Research Institute, University of Wales, New South Wales 2031, Australia
    J Appl Physiol 97:236-42. 2004
    ..Furthermore, its reliability and variability were similar to the resting twitch estimated from 30 contractions and to that evoked by conventional motor nerve stimulation...
  101. ncbi Effects of attention and precision of exerted force on beta range EEG-EMG synchronization during a maintained motor contraction task
    Rumyana Kristeva-Feige
    Neurological Clinic, Albert Ludwigs University, Breisacherstrasse 64, 79106 Freiburg, Germany
    Clin Neurophysiol 113:124-31. 2002
    ..The present study was aimed at investigating the effect of attention and precision level of exerted force on beta range EEG-EMG synchronization...

Research Grants62

  1. Role of Thromboxane in the Exercise Pressor Reflex in Peripheral Artery Disease
    ANNA KATHERINE LEAL; Fiscal Year: 2013
    ..these studies will address how exercise training affects thromboxane A2 production during rest and isometric contraction and describe how exercise augments the circulatory response to exercise pressor reflex activation in ..
  2. EM STUDIES ON MUSCLE
    KENNETH ALLEN TAYLOR; Fiscal Year: 2013
    ..Myosin motors during isometric contraction itself and following mechanical perturbations such as quick stretch and release will be trapped by fast ..
  3. CREATINE IN AMYOTROPHIC LATERAL SCLEROSIS
    Jeffrey Rosenfeld; Fiscal Year: 2004
    ..primary outcome measures are changes in disease progression rate as measured by 1) the maximum voluntary isometric contraction (MVIC) strength of ten arm muscle groups (bilateral shoulder and elbow flexion-extension and grip strength ..
  4. NEUTRON DIFFRACTION STUDIES OF MUSCLE CONTRACTION
    ROBERT MENDELSON; Fiscal Year: 1993
    ..is the average radial position of the light chain-bearing portion of the myosin head in a muscle during isometric contraction of muscle fibers? Does the intensity of the 14...
  5. Improving transcapillary transport by reducing interstitial fluid pressure
    LEONARDO CARVALHO; Fiscal Year: 2009
    ..Similar to isometric contraction of skeletal muscle, neovascular pericytes generate contractile forces not only on the vessel walls but ..
  6. NEUROHORMONAL REGULATION OF COLONIC SMOOTH MUSCLE
    WILLIAM SNAPE; Fiscal Year: 1992
    ..muscles will be estimated by determining the effect of inositol trisphosphate (InsP) or caffeine, on isometric contraction. The quantity of Ca2+3 released from the SR will be measured with a Ca2+ electrode and 43Ca efflux after ..
  7. IGF-I/ALS Trial
    Eric Sorenson; Fiscal Year: 2007
    ..measures of muscle function, mechanical measurement of maximum force generated by voluntary isometric contraction of muscle (MVIC) or manual muscle testing (MMT)...
  8. CA++ SENSITIVITY IN STUNNED CARDIAC MYOCYTES
    MATTHEW WOLFF; Fiscal Year: 2000
    ..3) Investigate whether stunning depresses the kinetics of cross-bridge cycling during isometric contraction by measuring the rate constant of isometric force redevelopment (Ktr)...
  9. ROLE OF ENKEPHALINASE IN REGULATING AIRWAYS
    D Borson; Fiscal Year: 1991
    ..I will measure isometric contraction of airway smooth muscle using standard methods...
  10. Mentored Patient Oriented Research Career Development
    Diana Escolar; Fiscal Year: 2005
    ..Aim 3 is to validate the specificity of the pediatric QMT system measuring maximal voluntary isometric contraction sequentially in children with DMD...
  11. Neuromuscular Fatigue in Older Adults
    Sandra Hunter; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  12. Task Dependence of Muscle Fatigue in Older Adults
    Sandra Hunter; Fiscal Year: 2005
    ..to adapt to different fatiguing tasks? In young adults, the endurance time when performing a submaximal isometric contraction was longer when maintaining a force and pushing against a force transducer (force task) compared with ..
  13. STRUCTURAL DYNAMICS AT THE ACTO MYOSIN INTERFACE
    Christopher Berger; Fiscal Year: 2000
    ..mediating the acto- myosin interaction, determine the fraction of actin-attached myosin molecules during isometric contraction and its relationship to muscle fiber stiffness, determine whether or not all strongly bound myosin cross-..
  14. Visuomotor contributions to unsteadiness in frail aging
    BRIAN TRACY; Fiscal Year: 2008
    ..Greater knowledge of these changes in the nervous system of aging Americans can lead to the application of more effective intervention strategies to combat frailty and functional disability in the elderly. [unreadable] [unreadable]..
  15. Aging,Gender, and Steadiness of Muscle Contractions
    BRIAN TRACY; Fiscal Year: 2006
    ..The Sponsor, host department, and interactions with other prominent, funded investigators will provide a rich, supportive environment that will substantially enhance the career development of the candidate. ..
  16. Hand Function in Multiple Sclerosis
    Slobodan Jaric; Fiscal Year: 2006
    ....
  17. MOLECULAR ANGLE TRANSITIONS IN MUSCLE
    THOMAS BURGHARDT; Fiscal Year: 2001
    ....
  18. Regulation of Vascular Tone and Ca channels by Integrins
    Michael Davis; Fiscal Year: 2009
    ..We will determine how these proteins are modified by the same processes as found in the diseases states and then test the effects they have on vascular ion channels and blood vessel function. ..
  19. Regulation of Arteriolar Tone & K Channels by Integrins
    Michael Davis; Fiscal Year: 2006
    ..In addition, our results will establish a paradigm for understanding how other ion channels in other tissues may be regulated by integrins. ..
  20. Linking motor imagery to motor execution
    Sheng Li; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  21. Myocardial Stiffness in Aging Associated Diastolic Heart Failure
    Kenneth Campbell; Fiscal Year: 2007
    ..The experimental results will provide new information about the underlying causes of DHF and should help scientists develop better treatments for diastolic dysfunction in elderly populations. [unreadable] [unreadable] [unreadable]..
  22. Wearable-Sensor System for Monitoring Motor Function
    Carlo J De Luca; Fiscal Year: 2010
    ..The successful development of this technology will be transferred for commercial development with the financial assistance of the Massachusetts Community Technology Foundation. ..
  23. Non-Invasive System for Identifying Neural Behavior
    Carlo De Luca; Fiscal Year: 2009
    ..It will be useful to clinicians for assessing the degree of dysfunction in upper motoneuron diseases such as Cerebral Palsy, Parkinson's Disease, ALS, Stroke, and other disorders. ..
  24. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2009
    ..abstract_text> ..
  25. Transmitter Repletion: Key to Phrenic-Diaphragm Function
    Erik van Lunteren; Fiscal Year: 2005
    ..These studies may lead to novel therapeutic approaches to respiratory muscle impairment and resulting hypercapnic respiratory failure for conditions which produce neuromuscular junction dysfunction. ..
  26. SHEAR STRESS INDUCED RELEASE OF ENDOTHELIAL NITRIC OXIDE
    Michael Davis; Fiscal Year: 2001
    ....
  27. HARNESSING MOTONEURON ACTIVITY: FROM LAB TO CLINIC
    Carlo De Luca; Fiscal Year: 2004
    ..As well as testing specific hypotheses, these studies will be used to test and improve the evolving design of the new decomposition system. ..
  28. MECHANISM AND FUNCTION OF THE VASCULAR MYOGENIC RESPONSE
    Michael Davis; Fiscal Year: 2002
    ....
  29. Molecular determinants of exercise-induced muscle damage
    Monica Hubal; Fiscal Year: 2004
    ..Understanding these processes could lead to novel treatments for musculodystrophy and other myopathies that are characterized by muscle degradation. ..
  30. fMRI Activity During the Visual Control of Force
    DAVID VAILLANCOURT; Fiscal Year: 2004
    ..These findings will have further implications for better understanding the visuomotor control deficits associated with aging, and diseased persons with Parkinson's disease, ataxia, and cerebellar deficits. ..
  31. A RENEW Intervention for Elderly Cancer Survivors
    Paul Lastayo; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. MUSCULOSKELETAL PLASTICITY AFTER SPINAL CORD INJURY
    RICHARD SHIELDS; Fiscal Year: 2003
    ..The benefits of this newly developed adaptive feedback controlled exercise may provide a standard that individuals with paralysis may use in an effort to maintain their musculoskeletal properties following paralysis. ..
  33. Progressive scoliosis deformity in intervertebral disc
    Ian Stokes; Fiscal Year: 2009
    ..These approaches may include improvements in brace design, new possibilities for muscle rehabilitation, and surgical procedures aimed at early, minimally invasive modification of spinal growth. ..
  34. Motor Unit Discharge and Slowed Motor Output in Elderly
    Christopher Knight; Fiscal Year: 2008
    ..This project also provides the basis for future research on the adaptability of these neural factors and function in older adults and patient populations. [unreadable] [unreadable]..
  35. IMAGING MELANIN IN MELANOCYTES
    Julian Borejdo; Fiscal Year: 2003
    ..The modifications are relatively simple, inexpensive and not tied to a specific brand of instrument. It is expected that the method will find application in a small diagnostic laboratory. ..
  36. MECHANICAL MODULATION OF GROWTH IN PHYSES
    Ian Stokes; Fiscal Year: 2003
    ..abstract_text> ..
  37. STABILITY OF MUSCULAR LOADING OF THE LUMBAR SPINE
    Ian Stokes; Fiscal Year: 2002
    ..In addition, the specific roles of individual muscles will be better elucidated, which will be helpful in guiding therapy for people with low back dysfunction. ..
  38. MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA
    STEPHEN ALWAY; Fiscal Year: 2001
    ....
  39. NEUROMECHANICS OF KNEE EXTENSOR/MALALIGNMENT
    Li Qun Zhang; Fiscal Year: 2002
    ..Changes in the above properties induced by patellar malalignment and correction induced by patellar taping will be quantified using the above designs. ..
  40. SKELETAL MUSCLE PROTEIN METABOLISM IN HEART FAILURE
    MICHAEL TOTH; Fiscal Year: 2003
    ..These experiments will provide new information regarding the pathophysiological mechanisms responsible for the loss of skeletal muscle mass and strength in heart failure patients. ..
  41. Skeletal muscle contractile dysfunction in heart failure
    MICHAEL TOTH; Fiscal Year: 2009
    ..Our findings will also provide information regarding the utility of resistance exercise training to improve single muscle fiber function, as well as whole muscle performance and whole body physical function in heart failure patients. ..
  42. Improved Confocal Microscope: Detection & Functionality
    Julian Borejdo; Fiscal Year: 2005
    ..To facilitate a future commercialization, a microscope maintenance/modification company that is interested in distribution of the product version of the modification package has been identified. ..
  43. Aging and Movement Accuracy
    Evangelos Christou; Fiscal Year: 2005
    ..These preliminary findings will form the foundation for an RO1 application that will further explore the mechanisms contributing to the impaired movement accuracy in older adults. ..
  44. Single Muscle Fiber Contractile Properties With Aging
    Scott Trappe; Fiscal Year: 2005
    ..With this information we will be able to determine, for the first time, the interaction of aging, resistance training, and gender on single muscle fiber contractile function. ..
  45. Investigation of Human Muscle Function in vivo
    BRUCE DAMON; Fiscal Year: 2005
    ..In this application we have requested partial support for the trainees to attend and benefit from the workshop; we have also requested support for a minority trainee travel stipend program...
  46. Neuromechanical changes caused by stroke & stretching
    Li Qun Zhang; Fiscal Year: 2006
    ..The long-term goals are to provide effective, convenient, and low-cost treatments of spastic limbs in neurologically impaired patients with quantitative outcome evaluation in multiple aspects. ..
  47. Human Motor Unit Discharge Variability
    Christopher Knight; Fiscal Year: 2002
    ..Like the research on heart rate variability, I hope to provide effective diagnostic tools for evaluating neuromuscular health. ..
  48. AN INTEGRATED MODEL OF INTERVERTEBRAL DISC FUNCTION
    Ian Stokes; Fiscal Year: 2006
    ..and the local conditions that can influence its metabolism, eventual composition and function in three-dimensions. ..
  49. ACL injury mechanisms & offaxis neuromuscular diagnosis & training
    Li Qun Zhang; Fiscal Year: 2010
    ....
  50. Developing an intelligent & portable stretching device
    Li Qun Zhang; Fiscal Year: 2006
    ..The overall objectives of the Phase II project are to develop an effective, portable, low-cost, and user-friendly intelligent stretcher, suitable and economical for patients to use in clinic or home and ready for commercialization. ..
  51. SKELETAL MUSCLE PROTEIN METABOLISM IN HEART FAILURE
    MICHAEL TOTH; Fiscal Year: 2001
    ..These experiments will provide new information regarding the pathophysiological mechanisms responsible for the loss of skeletal muscle protein quality and quantity in heart failure patients. ..
  52. Frequency of aerobic/resistance training in older women
    Gary Hunter; Fiscal Year: 2009
    ..Such information is critical to our understanding of ways to improve well being, quality of life, and independence of an aging population. ..
  53. Neuro-Musculoskeletal Plasticity after SCI
    Richard K Shields; Fiscal Year: 2010
    ..The proposed method not only has excellent potential for efficacy, but is also likely to be economical and easily integrated into the daily lives of people with SCI. ..
  54. MRI Detection of Skeletal Muscle Microvascular Dysfunction
    BRUCE DAMON; Fiscal Year: 2007
    ..Specific Aim 1 is to test the hypothesis that analysis of post-isometric contraction changes in proton density-weighted MRI signals will reproducibly and reliably distinguish between T2DM ..
  55. Rotation of Single Cross-Bridge in Skeletal Muscle Fiber
    Julian Borejdo; Fiscal Year: 2007
    ..This is expected to provide definitive answers about the mechanism of contraction of skeletal muscle. ..
  56. Id2 REGULATION OF MUSCLE HYPERTROPHY IN AGING
    STEPHEN ALWAY; Fiscal Year: 2007
    ..abstract_text> ..
  57. Effects of ovarian suppression on substrate metabolism
    MICHAEL TOTH; Fiscal Year: 2007
    ..Our findings will have direct relevance to understanding the fundamental role of ovarian hormone deficiency in the physiologic and metabolic changes that occur with menopause. ..
  58. Muscle Properties During Normal Movements
    THOMAS SANDERCOCK; Fiscal Year: 2006
    ..These results will be important for rehabilitation engineering, providing a quantitative guide for muscle selection in tendon transfer surgeries and functional neuromuscular stimulation. ..
  59. ELASTIC/PLASTIC HUMAN JOINT COMPLIANCE
    SERGE ROY; Fiscal Year: 2004
    ..The fourth task examines the postural aspects of the central commands and the relatively little studied aspects of how the CNS controls the transition from movement to posture. ..
  60. Quantifying Oxidative Metabolism in Diabetic Muscle
    BRUCE DAMON; Fiscal Year: 2005
    ..Moreover, these techniques will be suitable for future studies of the effects of exercise training or other interventions in diabetic animal models. ..
  61. Estimating Joint Impedance from the Surface EMG
    EDWARD CLANCY; Fiscal Year: 2004
    ..abstract_text> ..
  62. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2005
    ..The design of these studies will increase our understanding of how the vestibular system contributes to orthostatic blood pressure regulation in humans. ..