muscle contraction

Summary

Summary: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Top Publications

  1. pmc Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Physiol Rev 88:1243-76. 2008
  2. ncbi Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses
    Georg Nagel
    Max Planck Institute for Biophysics, Max von Laue Str 3, D 60438 Frankfurt, Germany
    Curr Biol 15:2279-84. 2005
  3. pmc IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
    Makoto Kudo
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Nat Med 18:547-54. 2012
  4. ncbi Spinal and supraspinal factors in human muscle fatigue
    S C Gandevia
    Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Randwick, Sydney, Australia
    Physiol Rev 81:1725-89. 2001
  5. ncbi Changes in agonist-antagonist EMG, muscle CSA, and force during strength training in middle-aged and older people
    K HAkkinen
    Neuromuscular Research Center and Department of Biology of Physical Activity, University of Jyvaskyla, 40351 Jyväskylä, Finland
    J Appl Physiol (1985) 84:1341-9. 1998
  6. pmc Increased vascular smooth muscle contractility in TRPC6-/- mice
    Alexander Dietrich
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Germany
    Mol Cell Biol 25:6980-9. 2005
  7. pmc Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
    Fen Huang
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:16354-9. 2012
  8. pmc Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
    Thomas Boettger
    Max Planck Institut für Herz und Lungenforschung, Bad Nauheim, Germany
    J Clin Invest 119:2634-47. 2009
  9. ncbi Regulation of mitochondrial biogenesis in skeletal muscle by CaMK
    Hai Wu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 296:349-52. 2002
  10. doi Effect of contrasting physical exercise interventions on rapid force capacity of chronically painful muscles
    Lars L Andersen
    National Research Centre for the Working Environment, Lersø Parkalle 105 DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 107:1413-9. 2009

Detail Information

Publications365 found, 100 shown here

  1. pmc Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Physiol Rev 88:1243-76. 2008
    ..Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction...
  2. ncbi Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses
    Georg Nagel
    Max Planck Institute for Biophysics, Max von Laue Str 3, D 60438 Frankfurt, Germany
    Curr Biol 15:2279-84. 2005
    ..Thus, specific neurons or muscles expressing ChR2 can be quickly and reversibly activated by light in live and behaving, as well as dissected, animals...
  3. pmc IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
    Makoto Kudo
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Nat Med 18:547-54. 2012
    ..These data indicate that the IL-17A produced by T(H)17 cells contributes to allergen-induced airway hyper-responsiveness through direct effects on airway smooth muscle...
  4. ncbi Spinal and supraspinal factors in human muscle fatigue
    S C Gandevia
    Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Randwick, Sydney, Australia
    Physiol Rev 81:1725-89. 2001
    ..A number of other central changes occur during fatigue and affect, for example, proprioception, tremor, and postural control. Human muscle fatigue does not simply reside in the muscle...
  5. ncbi Changes in agonist-antagonist EMG, muscle CSA, and force during strength training in middle-aged and older people
    K HAkkinen
    Neuromuscular Research Center and Department of Biology of Physical Activity, University of Jyvaskyla, 40351 Jyväskylä, Finland
    J Appl Physiol (1985) 84:1341-9. 1998
    ....
  6. pmc Increased vascular smooth muscle contractility in TRPC6-/- mice
    Alexander Dietrich
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Germany
    Mol Cell Biol 25:6980-9. 2005
    ..Thus, TRPC6 has distinct nonredundant roles in the control of vascular smooth muscle tone...
  7. pmc Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
    Fen Huang
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:16354-9. 2012
    ..TMEM16A-CaCC blockers, including those identified here, may positively impact multiple causes of asthma symptoms...
  8. pmc Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
    Thomas Boettger
    Max Planck Institut für Herz und Lungenforschung, Bad Nauheim, Germany
    J Clin Invest 119:2634-47. 2009
    ..We conclude that manipulation of miR-143/145 expression may offer a new approach for influencing vascular repair and attenuating arteriosclerotic pathogenesis...
  9. ncbi Regulation of mitochondrial biogenesis in skeletal muscle by CaMK
    Hai Wu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 296:349-52. 2002
    ..Thus, a calcium-regulated signaling pathway controls mitochondrial biogenesis in mammalian cells...
  10. doi Effect of contrasting physical exercise interventions on rapid force capacity of chronically painful muscles
    Lars L Andersen
    National Research Centre for the Working Environment, Lersø Parkalle 105 DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 107:1413-9. 2009
    ..Potentially, the present method can be a useful clinical screening tool of muscle function in rehabilitation settings...
  11. pmc Boosting cortical activity at Beta-band frequencies slows movement in humans
    Alek Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, UK
    Curr Biol 19:1637-41. 2009
    ....
  12. pmc Role of potassium ion channels in detrusor smooth muscle function and dysfunction
    Georgi V Petkov
    Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Coker Life Sciences Building, Room 609D, 715 Sumter Street, Columbia, SC 29208, USA
    Nat Rev Urol 9:30-40. 2012
    ..This Review summarizes our current state of knowledge of the functional role of K(+) channels in DSM in health and disease, with special emphasis on current advancements in the field...
  13. ncbi A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle
    J Mu
    Howard Hughes Medical Institute, The Cox Institute, The Department of Medicine, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Mol Cell 7:1085-94. 2001
    ..These data indicate that AMPK transmits a portion of the signal by which muscle contraction increases glucose uptake, but other AMPK-independent pathways also contribute to the response.
  14. pmc Structured variability of muscle activations supports the minimal intervention principle of motor control
    Francisco J Valero-Cuevas
    Department of Biomedical Engineering, The University of Southern California, 3710 McClintock Ave, RTH 404, Los Angeles, California 90089 2905, USA
    J Neurophysiol 102:59-68. 2009
    ..Additionally, variance is nonnegligible in all seven dimensions, which is at odds with the view that muscle activation patterns are composed from a small number of synergies...
  15. ncbi Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway
    Takayuki Akimoto
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:19587-93. 2005
    ..These findings suggest that contractile activity-induced activation of the p38 MAPK pathway promotes Pgc-1alpha gene expression and skeletal muscle adaptation...
  16. pmc Hyperthermia: a failure of the motor cortex and the muscle
    Gabrielle Todd
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney 2031, Australia
    J Physiol 563:621-31. 2005
    ..The increased central fatigue during hyperthermia may represent a failure of descending voluntary drive to compensate for changed muscle properties, despite the availability of additional cortical output...
  17. ncbi Relation between stimulation characteristics and clinical outcome in studies using electrical stimulation to improve motor control of the upper extremity in stroke
    Joke R de Kroon
    Roessingh Research and Development Enschede The Netherlands
    J Rehabil Med 37:65-74. 2005
    ..The aim of this review is to explore the relationship between characteristics of stimulation and the effect of electrical stimulation on the recovery of upper limb motor control following stroke...
  18. ncbi Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?
    Luke J Janssen
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Hospital, McMaster University, Hamilton, Ontario, Canada L8N 4A6
    Am J Physiol Lung Cell Mol Physiol 282:L1161-78. 2002
    ..Also, we will examine some novel ionic mechanisms in the context of Ca(2+) handling and excitation-contraction coupling in ASM...
  19. ncbi Age-related changes in the structure and function of skeletal muscles
    John A Faulkner
    Molecular and Integrative Physiology, and Biomedical Engineering, Biomedical Science Research Building, University of Michigan, Ann Arbor, Michigan, USA
    Clin Exp Pharmacol Physiol 34:1091-6. 2007
    ....
  20. doi Skeletal muscle fatigue: cellular mechanisms
    D G Allen
    School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia
    Physiol Rev 88:287-332. 2008
    ....
  21. ncbi Hyperthermia and central fatigue during prolonged exercise in humans
    L Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2200 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 91:1055-60. 2001
    ..In conclusion, these data demonstrate that the ability to generate force during a prolonged MVC is attenuated with hyperthermia, and the impaired performance is associated with a reduction in the voluntary activation percentage...
  22. pmc Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
    Christian Pehmøller
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Dept of Exercise and Sport Sciences, Univ of Copenhagen, DK 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E665-75. 2009
    ..insulin, growth factors, pharmacological agonists that activate 5'-AMP-activated protein kinase (AMPK), and muscle contraction. Silencing TBC1D1 in L6 muscle cells by siRNA increases insulin-stimulated GLUT4 translocation, and ..
  23. doi Motor unit recruitment during neuromuscular electrical stimulation: a critical appraisal
    C Scott Bickel
    Department of Physical Therapy, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 1212, USA
    Eur J Appl Physiol 111:2399-407. 2011
    ....
  24. ncbi Changes in segmental and motor cortical output with contralateral muscle contractions and altered sensory inputs in humans
    Tibor Hortobagyi
    East Carolina University, Biomechanics Laboratory, Greenville, North Carolina 27858, USA
    J Neurophysiol 90:2451-9. 2003
    ..while the left arm underwent unilateral interventions (5 s duration) that included voluntary contraction, muscle contraction evoked through percutaneous stimulation, tendon vibration, and cutaneous and mixed nerve stimulation...
  25. doi Insights gained into the interpretation of surface electromyograms from the gastrocnemius muscles: A simulation study
    Luca Mesin
    Department of Electronics, Politecnico di Torino, Torino, Italy
    J Biomech 44:1096-103. 2011
    ..These results are discussed on a physiological context, highlighting the relevance of the model proposed here for the interpretation of gastrocnemius EMGs and for conceiving future experiments on muscles with pinnate geometry...
  26. ncbi Swimming of larval zebrafish: ontogeny of body waves and implications for locomotory development
    Ulrike K Müller
    Wageningen University, Experimental Zoology Group, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    J Exp Biol 207:853-68. 2004
    ..2) and strain rates (up to 30 s(-1) in white muscle fibres) yet are able to power swimming for several seconds...
  27. ncbi Urinary bladder contraction and relaxation: physiology and pathophysiology
    Karl Erik Andersson
    Dept of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Physiol Rev 84:935-86. 2004
    ..Alterations in these systems in pathological conditions of the bladder wall are described, and some areas for future research are suggested...
  28. pmc A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release
    Zhitao Hu
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuron 71:92-102. 2011
    ..Collectively, these results suggest that NLP-12 mediates a mechanosensory feedback loop that couples muscle contraction to changes in presynaptic release, thereby providing a mechanism for proprioceptive control of locomotion.
  29. ncbi Three myosin heavy chain isoforms in type 2 skeletal muscle fibres
    S Schiaffino
    Institute of General Pathology, University of Padova, Italy
    J Muscle Res Cell Motil 10:197-205. 1989
    ..Muscles containing predominantly 2X-MHC display a velocity of shortening intermediate between that of slow muscles and that of fast muscles composed predominantly of 2B fibres...
  30. ncbi Increased rate of force development and neural drive of human skeletal muscle following resistance training
    Per Aagaard
    Department of Neurophysiology, Institute of Medical Physiology, Bispebjerg Hospital, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Appl Physiol (1985) 93:1318-26. 2002
    ..has important functional consequences as it determines the force that can be generated in the early phase of muscle contraction (0-200 ms)...
  31. ncbi Interstitial muscle lactate, pyruvate and potassium dynamics in the trapezius muscle during repetitive low-force arm movements, measured with microdialysis
    L Rosendal
    National Institute of Occupational Health, Copenhagen, Denmark
    Acta Physiol Scand 182:379-88. 2004
    ..Local muscle metabolic responses to repetitive low-force contractions and to intense static contractions were studied by microdialysis in humans...
  32. ncbi Exercise-induced muscle damage in humans
    Priscilla M Clarkson
    Department of Exercise Science, Totman Building, University of Massachusetts, Amherst, MA 01003, USA
    Am J Phys Med Rehabil 81:S52-69. 2002
    ....
  33. pmc Reflex regulation during sustained and intermittent submaximal contractions in humans
    Jacques Duchateau
    Laboratory of Biology, Universite Libre de Bruxelles, 28 avenue P Héger, CP 168, Belgium
    J Physiol 541:959-67. 2002
    ..This decline in excitation to the motoneurones, however, can be temporarily compensated by an enhancement of the central drive...
  34. ncbi Reliability and validity of the Biodex system 3 pro isokinetic dynamometer velocity, torque and position measurements
    Joshua M Drouin
    Department of Public Health, Georgia Southern University, PO Box 8076, Statesboro, GA 30460 8076, USA
    Eur J Appl Physiol 91:22-9. 2004
    ..With the exception of a systematic decrease in velocity at speeds of 300 degrees/s and higher, the Biodex System 3 performed with acceptable mechanical reliability and validity on all variables tested...
  35. ncbi Recruitment patterns in human skeletal muscle during electrical stimulation
    Chris M Gregory
    Department of Physical Therapy, University of Florida, Room 1142, HPNP Bldg, 101 S Newell Dr, Gainesville, FL 32610, USA
    Phys Ther 85:358-64. 2005
    ..The authors believe the majority of evidence suggests that EMS-induced motor unit recruitment is nonselective and that muscle fibers are recruited without obvious sequencing related to fiber types...
  36. ncbi Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content
    C Keller
    The Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, Denmark
    FASEB J 15:2748-50. 2001
    ..These findings also support the hypothesis that IL-6 may be produced by contracting myofibers when glycogen levels become critically low as a means of signaling the liver to increase glucose production...
  37. pmc Neural control of shortening and lengthening contractions: influence of task constraints
    Jacques Duchateau
    Laboratory of Applied Biology, Universite Libre de Bruxelles, Route de Lennik, 808, CP 640, 1070 Brussels, Belgium
    J Physiol 586:5853-64. 2008
    ....
  38. pmc Signaling processes for initiating smooth muscle contraction upon neural stimulation
    Hai Lei Ding
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 284:15541-8. 2009
    ..Thus, neural stimulation leads to rapid increases in [Ca2+](i), MLCK activation, and RLC phosphorylation in phasic smooth muscle, showing a tightly coupled Ca2+ signaling complex as an elementary mechanism initiating contraction...
  39. pmc Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men
    Christopher S Fry
    University of Texas Medical Branch, Sealy Center on Aging, Department of Physical Therapy, Division of Rehabilitation Sciences, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol (1985) 108:1199-209. 2010
    ..05). We conclude that low-intensity RE in combination with BFR enhances mTORC1 signaling and MPS in older men. BFR exercise is a novel intervention that may enhance muscle rehabilitation to counteract sarcopenia...
  40. pmc Model of sarcomeric Ca2+ movements, including ATP Ca2+ binding and diffusion, during activation of frog skeletal muscle
    S M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6085, USA
    J Gen Physiol 112:297-316. 1998
    ..We conclude that Ca2+ binding by ATP and diffusion of CaATP make important contributions to the determination of the amplitude and the time course of Delta[Ca2+]...
  41. ncbi Myosin phosphatase: structure, regulation and function
    Masaaki Ito
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    Mol Cell Biochem 259:197-209. 2004
    Phosphorylation of myosin II plays an important role in many cell functions, including smooth muscle contraction. The level of myosin II phosphorylation is determined by activities of myosin light chain kinase and myosin phosphatase (MP)...
  42. doi Heterogeneity of muscle activation in relation to force direction: a multi-channel surface electromyography study on the triceps surae muscle
    D Staudenmann
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Vander Boechorstraat 9, 1081 BT Amsterdam, The Netherlands
    J Electromyogr Kinesiol 19:882-95. 2009
    ..The correlations between cluster time series and forces at the foot in specific directions differed substantially between clusters, showing that the differentially activated parts of the TS had specific biomechanical functions...
  43. doi Factors influencing cortical silent period: optimized stimulus location, intensity and muscle contraction
    Laura Säisänen
    Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
    J Neurosci Methods 169:231-8. 2008
    ..MEP should be included in SP as the error from marking the onset diminishes. This study provides a guideline for the consistent measurement of SP, which is applicable when using navigated or traditional TMS...
  44. ncbi Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    M Uehata
    Discovery Research Tokyo, Yoshitomi Pharmaceutical Industries Ltd, Saitama, Japan
    Nature 389:990-4. 1997
    ..Smooth-muscle contraction is regulated by the cytosolic Ca2+ concentration and by the Ca2+ sensitivity of myofilaments: the former ..
  45. ncbi The molecular mechanism of muscle contraction
    Michael A Geeves
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Adv Protein Chem 71:161-93. 2005
  46. ncbi IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle
    Adam Steensberg
    Copenhagen Muscle Research Centre and Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 283:E1272-8. 2002
    ..In contrast, IL-6 increased throughout exercise in arterial plasma, and a net IL-6 release from the contracting limb was observed after 120 min of exercise (P < 0.05)...
  47. ncbi Measurement of muscle contraction with ultrasound imaging
    P W Hodges
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, New South Wales 2031, Australia
    Muscle Nerve 27:682-92. 2003
    ..Obliquus externus abdominis thickness did not change consistently with muscle contraction, so ultrasound measures of thickness cannot be used to detect activity of this muscle...
  48. ncbi An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle
    Jay P Shah
    Rehabilitation Medicine Department, Clinical Research Center, NIH, Bethesda, MD 20814, USA
    J Appl Physiol (1985) 99:1977-84. 2005
    ..The measured levels of analytes can be used to distinguish clinically distinct groups...
  49. pmc Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis
    Micah J Drummond
    Departments of Physical Therapy, University of Texas Medical Branch, Galveston, 77555 1144, USA
    J Physiol 587:1535-46. 2009
    Muscle protein synthesis and mTORC1 signalling are concurrently stimulated following muscle contraction in humans...
  50. ncbi The troponin complex and regulation of muscle contraction
    C S Farah
    Departamento de Bioquimica, Universidade de Sao Paulo, Brazil
    FASEB J 9:755-67. 1995
    In a wide variety of cellular settings, from organelle transport to muscle contraction, Ca2+ binding to members of the EF hand family of proteins controls the interaction between actin and different myosins that are responsible for ..
  51. doi Effects of commonly used protein kinase inhibitors on vascular contraction and L-type Ca(2+) current
    Simona Saponara
    Dipartimento di Neuroscienze, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Biochem Pharmacol 84:1055-61. 2012
    Regulation of smooth muscle contraction is driven by a number of protein kinases: the evidence for this often originates from studies that investigate the effects of extracellularly added specific protein kinase inhibitors...
  52. pmc MC sensor--a novel method for measurement of muscle tension
    Srđan Đorđević
    TMG BMC Ltd, Splitska 5, 1000 Ljubljana, Slovenia
    Sensors (Basel) 11:9411-25. 2011
    This paper presents a new muscle contraction (MC) sensor. This MC sensor is based on a novel principle whereby muscle tension is measured during muscle contractions...
  53. ncbi Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
    K Kimura
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 01, Japan
    Science 273:245-8. 1996
    ..Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase...
  54. pmc Self-organization of muscle cell structure and function
    Anna Grosberg
    Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 7:e1001088. 2011
    ....
  55. ncbi Regulation of contraction in striated muscle
    A M Gordon
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195 7290, USA
    Physiol Rev 80:853-924. 2000
    ..9) Different Tn subunit isoforms can modulate the cross-bridge detachment rate as shown by studies with mutant regulatory proteins in myotubes and in in vitro motility assays. (ABSTRACT TRUNCATED)..
  56. doi Resolving the limb position effect in myoelectric pattern recognition
    Anders Fougner
    Department of Engineering Cybernetics, Norwegian University of Science and Technology, Trondheim, Norway
    IEEE Trans Neural Syst Rehabil Eng 19:644-51. 2011
    ..7% and 5.0%, respectively. Our study shows how sensor fusion (using EMG and accelerometers) may be an efficient method to mitigate the effect of limb position and improve classification accuracy...
  57. ncbi Co-activation of the abdominal and pelvic floor muscles during voluntary exercises
    R R Sapsford
    Department of Physiotherapy, Mater Misericordiae Hospital, Brisbane, Australia
    Neurourol Urodyn 20:31-42. 2001
    ..Both subjects showed an increase in EMG activity of the pubococcygeus with each abdominal muscle contraction. The results of these experiments indicate that abdominal muscle activity is a normal response to PF ..
  58. ncbi Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity
    Natalie Hiscock
    Skeletal Muscle Research Laboratory, Centre for Nutrition, Metabolism and Endocrinology, School of Medical Sciences, RMIT University, Melbourne, Australia
    FASEB J 18:992-4. 2004
    ..05). These data demonstrate that myocytes per se are a source of IL-6 produced during contraction. Our data also suggest that type 2 fibers predominantly produce IL-6 during muscle contractile activity...
  59. doi In isolated skeletal muscle, excitation may increase extracellular K+ 10-fold; how can contractility be maintained?
    Torben Clausen
    Department of Physiology and Biophysics, University of Aarhus, Ole Worms Alle 4, DK 8000 Arhus C, Denmark
    Exp Physiol 96:356-68. 2011
    ..These mechanisms are essential for the maintenance of force during intense contractions in vivo, where the clearance of K(+) via the capillaries may be suppressed...
  60. ncbi Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers
    Claudia Veigel
    Division of Physical Biochemistry, NIMR, The Ridgeway Mill Hill, London NW7 1AA, UK
    Nat Cell Biol 5:980-6. 2003
    b>Muscle contraction is driven by the cyclical interaction of myosin with actin, coupled with ATP hydrolysis...
  61. pmc SK but not IK channels regulate human detrusor smooth muscle spontaneous and nerve-evoked contractions
    Serge A Y Afeli
    Dept of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, Univ of South Carolina, Columbia, SC 29208, USA
    Am J Physiol Renal Physiol 303:F559-68. 2012
    ..In summary, our molecular and functional studies revealed that the SK, particularly the SK3 subtype, but not IK channels are expressed and regulate the spontaneous and nerve-evoked contractions in human DSM...
  62. ncbi Invited review: regulation of myosin phosphorylation in smooth muscle
    G Pfitzer
    Department of Physiology, University of Cologne, D 50931 Koeln, Germany
    J Appl Physiol (1985) 91:497-503. 2001
    ..Hence, smooth muscle tone appears to be regulated by a network of activating and inactivating intracellular signaling cascades...
  63. doi Protein kinase Cα activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscle
    Martin Thomassen
    Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 301:R1808-14. 2011
    ..In conclusion, exercise induces FXYD1 phosphorylation at multiple sites in human skeletal muscle. In mouse muscles, contraction-induced changes in FXYD1 ser68 phosphorylation are fiber-type specific and dependent on PKCα activity...
  64. doi Modulation of TRPV1-dependent contractility of normal and diabetic bladder smooth muscle by analgesic toxins from sea anemone Heteractis crispa
    Igor B Philyppov
    Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
    Life Sci 91:912-20. 2012
    ..Our aim was to investigate the effects of two novel polypeptide inhibitors of TRPV1 from the venom of tropical sea anemone Heteractis crispa, APHC1 and APHC3, on the contractions of DSM from bladders of normal and diabetic rats...
  65. doi Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task
    Shin Yi Chiou
    Department of Physical Therapy and Assistive Technology, National Yang Ming University, Taipei, Taiwan
    Clin Neurophysiol 124:1353-63. 2013
    ..This study aims to investigate the role of the primary motor cortex ipsilateral to the movement (ipsilateral M1) in unilateral motor execution...
  66. doi LIF is a contraction-induced myokine stimulating human myocyte proliferation
    Christa Broholm
    Rigshospitalet, Centre of Inflammation and Metabolism CIM 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 111:251-9. 2011
    ..Our data suggest that LIF is a contraction-induced myokine, potentially acting in an autocrine or paracrine fashion to promote satellite cell proliferation...
  67. doi Noninvasive estimation of myosin heavy chain composition in human skeletal muscle
    Bostjan Simunic
    Institute for Kinesiology Research, Science and Research Centre Koper, University of Primorska, Koper, Slovenia
    Med Sci Sports Exerc 43:1619-25. 2011
    ..Because there are only a few techniques available that noninvasively and accurately provide an estimate of muscle fiber type composition, the development of additional and alternative approaches is required...
  68. pmc Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent
    J Jeppesen
    Copenhagen Muscle Research Center, Molecular Physiology Group, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 52:699-711. 2011
    ..Furthermore, in the perfused rat hindlimb, muscle contraction induced a rapid (1 min, +15%) and sustained (10 min, +24%) FAT/CD36 relocation to cell surface membranes...
  69. pmc Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function
    Sebastian Albinsson
    Department of Pharmacology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e18869. 2011
    ..Although the phenotype of miR-143/145 deficient mice resembles the loss of Dicer, the phenotypes of SM-Dicer KO mice were far more severe suggesting that additional miRNAs are involved in maintaining postnatal SMC differentiation...
  70. pmc Postural activation of the human medial gastrocnemius muscle: are the muscle units spatially localised?
    Taian M M Vieira
    Laboratory for Engineering of the Neuromuscular System LISiN, Politecnico di Torino, Torino, Italy
    J Physiol 589:431-43. 2011
    ..It is concluded that relative to the whole muscle, and compared with the cat, muscle units in human MG are localised. The localisation of muscle units might have implications for the regional control of muscle activity...
  71. ncbi Na+-K+ pump regulation and skeletal muscle contractility
    Torben Clausen
    Department of Physiology, University of Aarhus, Arhus, Denmark
    Physiol Rev 83:1269-324. 2003
    ..The Na+-K+ pump is a central target for regulation of Na+-K+ distribution and excitability, essential for second-to-second ongoing maintenance of excitability during work...
  72. doi Cerebral perturbations during exercise in hypoxia
    Samuel Verges
    Laboratoire HP2 U1042 INSERM, UF Recherche sur l Exercice, Hopital Sud, Ave Kimberley, 38 434 Echirolles, France
    Am J Physiol Regul Integr Comp Physiol 302:R903-16. 2012
    ..Direct and indirect influences of arterial deoxygenation on central command are separated. Methodological concerns as well as future research avenues are also considered...
  73. doi Are the myoelectric manifestations of fatigue distributed regionally in the human medial gastrocnemius muscle?
    Alessio Gallina
    Laboratory for Engineering of the Neuromuscular System LISiN, Politecnico di Torino, Italy
    J Electromyogr Kinesiol 21:929-38. 2011
    ..Technically, the possibility of studying myoelectric fatigue in the MG muscle appears to depend on the electrode location...
  74. pmc Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost
    Murali Chandra
    Department of Physiology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, Arizona 85724 5217, USA
    J Biol Chem 284:30889-96. 2009
    ..nebulin is usually viewed as a structural protein, here we investigated whether nebulin plays a role in muscle contraction by using skinned muscle fiber bundles from a nebulin knock-out (NEB KO) mouse model...
  75. pmc Smooth muscle signalling pathways in health and disease
    H R Kim
    Department of Health Sciences, Boston University, Boston, MA 02215, USA
    J Cell Mol Med 12:2165-80. 2008
    ....
  76. doi Contractile activity of human skeletal muscle cells prevents insulin resistance by inhibiting pro-inflammatory signalling pathways
    S Lambernd
    German Diabetes Center, Auf m Hennekamp 65, Duesseldorf, Germany
    Diabetologia 55:1128-39. 2012
    ..We sought to establish and characterise an in vitro model of human skeletal muscle contraction, with a view to directly studying the signalling pathways and mechanisms that are involved in the beneficial ..
  77. doi A novel actin binding site of myosin required for effective muscle contraction
    Boglárka H Várkuti
    Department of Biochemistry, Eotvos Lorand University, Budapest, Hungary
    Nat Struct Mol Biol 19:299-306. 2012
    ..We conclude that the binding of actin to myosin's activation loop specifically increases the ratio of mechanically productive to futile myosin heads, leading to efficient muscle contraction.
  78. doi TNF-alpha acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle
    Brian J Hardin
    Dept of Physiology, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Appl Physiol (1985) 104:694-9. 2008
    ..We conclude that TNF acts via TNFR1 to stimulate oxidant activity and depress specific force. TNF effects on force are caused, at least in part, by decrements in function of calcium-activated myofibrillar proteins...
  79. doi Differential effects of peroxynitrite on contractile protein properties in fast- and slow-twitch skeletal muscle fibers of rat
    T L Dutka
    Dept of Zoology, La Trobe Univ, Melbourne 3086, Victoria, Australia
    J Appl Physiol (1985) 110:705-16. 2011
    ....
  80. pmc Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy
    Coen A C Ottenheijm
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    Hum Mol Genet 20:2015-25. 2011
    ..These findings provide a scientific basis for differential therapeutics aimed at restoring contractile performance in patients with TPM3-based versus NEB-based myopathy...
  81. ncbi ATP concentrations and muscle tension increase linearly with muscle contraction
    Jianhua Li
    Division of Cardiology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Appl Physiol (1985) 95:577-83. 2003
    ..in this reflex, it is necessary to examine whether muscle interstitial ATP (ATPi) concentrations rise with muscle contraction. Accordingly, in this study, muscle contraction was evoked by electrical stimulation of the L7 and S1 ..
  82. pmc Muscle time under tension during resistance exercise stimulates differential muscle protein sub-fractional synthetic responses in men
    Nicholas A Burd
    McMaster University, 1280 Main Street West, Hamilton, ON, Canada, L8S 4K1
    J Physiol 590:351-62. 2012
    ....
  83. ncbi AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle
    Henning F Kramer
    Joslin Diabetes Center Research Division, Metabolism Section, Massachusetts 02215, USA
    J Biol Chem 281:31478-85. 2006
    ..we measured [3H]2-deoxyglucose uptake in vivo following intravenous glucose administration and in situ muscle contraction, respectively...
  84. doi Altered corticospinal transmission to the hand after maximum voluntary efforts
    Sabine Giesebrecht
    Neuroscience Research Australia and the University of New South Wales, Barker Street, Randwick, Sydney, New South Wales 2031, Australia
    Muscle Nerve 43:679-87. 2011
    ..After maximal voluntary contractions (MVCs), responses to corticospinal tract stimulation change differently in arm and leg muscles. This study we examined responses in the first dorsal interosseous muscle (FDI)...
  85. pmc Acute colonic inflammation triggers detrusor instability via activation of TRPV1 receptors in a rat model of pelvic organ cross-sensitization
    Tirsit S Asfaw
    Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania, Glenolden, Pennsylvania 19036 2307, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1392-400. 2011
    ..Comparison of the results obtained under in vitro vs. in vivo conditions provides evidence that intact neural pathways are critical for the development of an overactive bladder resulting from pelvic organ cross talk...
  86. doi Principal components analysis preprocessing for improved classification accuracies in pattern-recognition-based myoelectric control
    Levi J Hargrove
    Institute of Biomedical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada
    IEEE Trans Biomed Eng 56:1407-14. 2009
    ..This processing technique was used to significantly ( p < 0.01) reduce pattern recognition classification error for both intact limbed and transradial amputee subjects...
  87. ncbi Contractile activity-induced oxidative stress: cellular origin and adaptive responses
    A McArdle
    Department of Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom
    Am J Physiol Cell Physiol 280:C621-7. 2001
    ..These changes occurred in the absence of overt damage to the muscle cells...
  88. doi Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle
    Manuel Morgado
    Health Sciences Research Centre CICS UBI, University of Beira Interior, Covilha, Portugal
    Cell Mol Life Sci 69:247-66. 2012
    ..This review focuses on each of these mechanisms involved in cyclic nucleotide-dependent relaxation of vascular smooth muscle under physiological conditions...
  89. pmc Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior
    Allyson J Whittaker
    Division of Biology Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    BMC Biol 7:33. 2009
    ..We provide a better understanding of the molecular and neuro-muscular pathways that regulate male tail posture during mating...
  90. doi Influence of vibration resistance training on knee extensor and plantar flexor size, strength, and contractile speed characteristics after 60 days of bed rest
    Edwin R Mulder
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University, Amsterdam, The Netherlands
    J Appl Physiol (1985) 107:1789-98. 2009
    ..Whereas contractile speed improved for the calf, the exercise regimen only partially preserved calf size and MVC strength. Modification of the exercise regimen seems warranted...
  91. ncbi Identification of passive elastic joint moments in the lower extremities
    R Riener
    Institute of Automatic Control Engineering, Technical University of Munich, Germany
    J Biomech 32:539-44. 1999
    ..The model can be implemented in biomechanical models of the lower extremities, which are generally used for the simulation of multi-joint movements such as standing-up, walking, running, or jumping...
  92. ncbi The effect of skinfold on frequency of human muscle mechanomyogram
    Anna Jaskólska
    University School of Physical Education, Department of Kinesiology, 51 629 Wrocław, ul Rzezbiarska 4, Poland
    J Electromyogr Kinesiol 14:217-25. 2004
    ..A use of force and skinfold thickness as covariates is recommended when an MMG frequency is analyzed in subjects differing in the skinfold thickness...
  93. pmc Musculoskeletal plasticity after acute spinal cord injury: effects of long-term neuromuscular electrical stimulation training
    Richard K Shields
    Graduate Program in Physical Therapy and Rehabilitation Science, The University of Iowa, Iowa City, IA 52242 1190, USA
    J Neurophysiol 95:2380-90. 2006
    ..Importantly, this method of load delivery was feasible and may serve as the basis for an intervention to preserve the musculoskeletal properties of individuals with SCI...
  94. ncbi Evaluation of female pelvic-floor muscle function and strength
    Kari Bø
    Norwegian University of Sport and Physical Education, PO Box 4014, Ulleval Stadion, 0806 Oslo, Norway
    Phys Ther 85:269-82. 2005
    ..Imaging techniques may become important clinical tools in future physical therapist practice and research to measure both pathophysiology and impairment of PFM dysfunction...
  95. ncbi Does the frequency content of the surface mechanomyographic signal reflect motor unit firing rates? A brief review
    Travis W Beck
    Department of Nutrition and Health Sciences, Human Performance Laboratory, University of Nebraska Lincoln, 104K Ruth Leverton Hall, Lincoln, NE 68583 0806, United States
    J Electromyogr Kinesiol 17:1-13. 2007
    ..It is likely, however, that this information is qualitative, rather than quantitative in nature, and reflects the global motor unit firing rate, rather than the firing rates of a particular group of motor units...
  96. ncbi Failed excitability of spinal motoneurons induced by prolonged running exercise
    S Racinais
    Faculté des Sciences du Sports, Laboratoire EA 2991, Efficience et Déficience Motrices, Universite de Montpellier 1, 700 Avenue du Pic Saint Loup, 34090 Montpellier, France
    J Neurophysiol 97:596-603. 2007
    ..In conclusion, the results regarding H-reflex and V-wave suggest for the first time a modulation in spinal loop properties after prolonged running...
  97. ncbi Clinical applications of high-density surface EMG: a systematic review
    Gea Drost
    Department of Clinical Neurophysiology, Institute of Neurology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Electromyogr Kinesiol 16:586-602. 2006
    ..We additionally discuss several bioengineering aspects and future clinical applications of the technique and provide recommendations for further development and implementation of HD-sEMG as a clinical diagnostic tool...
  98. ncbi Motor unit recruitment strategies investigated by surface EMG variables
    Dario Farina
    Centro di Bioingegneria, Department of Electronics, Politecnico di Torino, Torino 10129, Italy
    J Appl Physiol (1985) 92:235-47. 2002
    ..Our results do not support the establishment of a general relationship between spectral EMG variables and torque or recruitment strategy...
  99. pmc A review of non-invasive techniques to detect and predict localised muscle fatigue
    Mohamed R Al-Mulla
    School of Computer Science and Electronic Engineering, University of Essex, Colchester, UK
    Sensors (Basel) 11:3545-94. 2011
    ....
  100. ncbi Measurement and reproducibility of strength and voluntary activation of lower-limb muscles
    Gabrielle Todd
    Prince of Wales Medical Research Institute, Barker St, Randwick, New South Wales 2031, Australia
    Muscle Nerve 29:834-42. 2004
    ..The myograph system and the testing procedures should allow accurate measurement of strength and voluntary drive in longitudinal patient studies...
  101. pmc Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
    Kei Sakamoto
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, UK
    Am J Physiol Endocrinol Metab 295:E29-37. 2008
    Vesicular traffic of the glucose transporter GLUT4 occurs in response to insulin, muscle contraction, and metabolic stimuli that lead to changes in the energy status of the cell...

Research Grants73

  1. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ..The uniqueness of the proposed study exists on two fronts: the comparative efficacy of two muscle contraction types on knee OA symptoms and function in older adults will be determined, and the effects of two forms of ..
  2. Myosin phosphatase autoinhibition in gastrointestinal smooth muscle contraction
    Avril V Somlyo; Fiscal Year: 2012
    ..The results of the research should translate into novel treatments for targeting these diseases. ..
  3. Ionic currents in gastrointestinal smooth muscle
    Hamid I Akbarali; Fiscal Year: 2013
    ..transfer (FRET) and siRNA approaches to delineate the functional effect of src-Ca2+ channel interaction in muscle contraction. Preliminary data show that mutation of the terminal tyrosine residue within the c-terminus of the Ca2+ ..
  4. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2012
    ..pathophysiology of ANM, we will also gain important insights into the functional significance of different TnT isoforms and the Ca2+-regulation of striated muscle contraction, a fundamental topic in biology and medicine.
  5. Molecular physiology of voltage-gated Ca2+ channels
    Jian Yang; Fiscal Year: 2013
    ..Voltage-gated calcium channels (VGCCs) control and regulate numerous physiological processes, ranging from muscle contraction, heartbeat, neural communication and hormone secretion to cell differentiation, motility, growth and death...
  6. Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human Neurons
    JEN PAN; Fiscal Year: 2013
    ..Calcium is a second messenger whose intracellular concentration controls many cellular functions including muscle contraction, neurotransmitter release, cell survival and growth...
  7. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    ..including cardiac and neuronal excitation, sensory transduction, trans-epithelial secretion, smooth muscle contraction, and fertilization. In collaboration with Dr...
  8. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..enzyme, CBS v wild type littermates) indicate an impaired capacity for AVD in response to muscle contraction. Electron microscopy shows significant changes in the morphology of myoendothelial junctions in skeletal ..
  9. HEREDITARY DEFECTS IN HUMAN SODIUM CHANNELS
    Alfred L George; Fiscal Year: 2013
    ..A variety of inherited disorders affecting skeletal muscle contraction (hyperkalemic periodic paralysis, paramyotonia congenita, K+-aggravated myotonia), cardiac excitability (..
  10. Metabolic flux in a model of reduced oxidative capacity
    CHARLES ROBERT EVANS; Fiscal Year: 2013
    ..Dr. Cartee's lab uses in vitro muscle contraction in studies as a model for exercise, and will support Dr. Evans'training in these protocols. Research...
  11. Induction of Nerve Growth Factor by Nicotine Leads to Airway Dysfunction
    CHERRY P WONGTRAKOOL; Fiscal Year: 2013
    ..In Aim 2, we will demonstrate that airway smooth muscle contraction is increased and mediated by nerve growth factor by measuring bronchial ring contractility using isometric ..
  12. Molecular mechanism of regulation of mI(CAT) in intestinal smooth muscle cells
    Michael X Zhu; Fiscal Year: 2012
    ..trigger membrane depolarization and the subsequent intracellular calcium increase to cause smooth muscle contraction in the gastrointestinal system...
  13. Cellular Mechanisms of Lymphatic Muscle Contractility
    MICHAEL JOHN DAVIS; Fiscal Year: 2012
    ..We predict that the expression of these three proteins imparts the uniquely high rate of lymphatic muscle contraction/relaxation required for intrinsic pacemaker activity to be translated into efficient lymphatic pumping...
  14. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    ..receptors, capsaicin receptors (TRPV1) and acid sensing ion channels in evoking abnormal SNA responses to muscle contraction in HF...
  15. Molecular mechanics of mutant cardiac myosin
    Jeffrey R Moore; Fiscal Year: 2013
    ..Myosin, the sarcomeric molecular motor that interacts with actin to power cardiac muscle contraction, is a hexameric protein consisting of two heavy chains...
  16. Calcium Signaling, Metabolism, and EC Coupling in Heart
    Joshua I Goldhaber; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The investigators are studying the basic aspects of heart muscle contraction using single heart cells...
  17. Regulation of Rho Signaling by S-Nitrosothiols
    A Richard Whorton; Fiscal Year: 2012
    ..For example RhoA signaling through Rho-kinases regulate diverse vascular functions including smooth muscle contraction and migration, leukocyte-endothelial cell interactions, tissue factor expression, cell differentiation and ..
  18. Exercise and H2S mitigate homocysteine-mediated beta2-adrenergic receptor dysfunc
    Paras Kumar Mishra; Fiscal Year: 2013
    ..and HFD also down regulates sarco-endoplasmic reticulum ATPase 2a (serca2a;regulates calcium flux during muscle contraction), which is improved by exercise and H2S...
  19. Mechanisms of Neuroprotection in the Nucleus Tractus Solitarius of Hibernators
    BARBARA ANN HORWITZ; Fiscal Year: 2010
    ..receptors, capsaicin receptors (TRPV1) and acid sensing ion channels in evoking abnormal SNA responses to muscle contraction in HF...
  20. Myosin ELC, a novel therapeutic target for FHC
    Danuta Szczesna-Cordary; Fiscal Year: 2013
    ..THE MECHANISMS BY WHICH THE N-TERMINUS OF ELC REGULATES MYOSIN FORCE GENERATING CAPABILITY AND CARDIAC MUSCLE CONTRACTION. We hypothesize that the N- terminus of ELC interacts with the actin-tropomyosin-troponin filaments to ..
  21. Functional Consequences of FHC-linked RLC Mutations.
    Danuta Szczesna-Cordary; Fiscal Year: 2012
    ..calcium buffer? Do FHC mutations shift the metal occupancy of the RLC Ca2+-Mg2+ binding site during muscle contraction? SPECIFIC AIM 2: Is RLC phosphorylation by Ca2+-calmodulin (CaM) activated myosin light chain kinase (MLCK) ..
  22. Structural Dynamics of Cardiac Muscle Contraction
    Brett A Colson; Fiscal Year: 2012
    ..Protein kinase A (PKA)-dependent phosphorylation of cMyBP-C accelerates the kinetics of cardiac muscle contraction by relieving inhibitory effects of cMyBP-C, but there is controversy concerning whether these functional ..
  23. Regulation of gastrointestinal neuromuscular function by NIBP/NFkB signaling
    Wenhui Hu; Fiscal Year: 2013
    ..demonstrated that NFkB signaling in smooth muscle mediates inflammation-induced inhibition of colonic smooth muscle contraction. There is a fundamental gap in understanding how NFkB signaling from the ENS influences GI diseases...
  24. Regulatory Circuits Controlling Development of Dormant Microbial Cysts
    CARL EUGENE BAUER; Fiscal Year: 2013
    ..cGMP is a well known messenger in eukaryotes where it is involved in vision, muscle contraction, platelet aggregation, and development...
  25. MECHANISM OF INOSITOL TRISPHOSPHATE ACTION
    Suresh K Joseph; Fiscal Year: 2010
    ..temporal patterns in Ca2+ signaling that underlie a multitude of physiological processes as diverse as cell division, cell proliferation, apoptosis, fertilization, development, secretion, smooth muscle contraction, memory and learning.
  26. MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM IN MAN
    Lawrence J Mandarino; Fiscal Year: 2013
    ..Preliminary data indicate that acetylation of mitochondrial proteins in humans is regulated by muscle contraction and is dysregulated in insulin resistance...
  27. Spinal cord injury: Targeting local inhibition to improve outcome
    Linda J Noble; Fiscal Year: 2010
    ..The primary medications used to treat spasticity either enhance neural inhibition or inhibit muscle contraction. All have significant systemic side effects and do not completely eliminate spasticity...
  28. Mechanism of Thin Filament Regulation of Cardiac Actomyosin Hydrolysis
    Howard White; Fiscal Year: 2009
    ..proposed work is directly relevant to a number of diseases involving control of the regulation of cardiac muscle contraction, such as dilated cardiomyopathy, in which the force of the contraction is inadequate...
  29. The Regulation of Sarcomeric Function by Tropomyosin
    David F Wieczorek; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Striated muscle contraction is dependent upon a cooperative interaction between thick and thin filament sarcomeric proteins...
  30. Non-linear Characterization of the Stretch Reflex Arc and its Neuromodulation
    AMAN BEHAL; Fiscal Year: 2011
    ..Stretch Reflex Arc (SRA) is the simplest and most fundamental regulatory mechanism of posture control and muscle contraction. Understanding the details of the functioning of this important biological control system could (a) result ..
  31. Pharmacological Diversity of nAChRs in Clade III Nematodes: Levamisole receptors
    RICHARD JOHN MARTIN; Fiscal Year: 2013
    ..We have three aims. 3. Our approach will use muscle contraction assays, current-clamp, voltage-clamp, patch- clamp, cloning &Xenopus oocyte expression and ..
  32. Restrictive Cardiomyopathy Caused by Cardiac Troponin Mutations
    Xupei Huang; Fiscal Year: 2012
    ..Aim 1 will investigate how cTnI C-terminal mutations affect cardiac muscle contraction and relaxation in vitro and in vivo...
  33. Novel Cytokine Regulation of Gut Function and Inflammation
    Aiping Zhao; Fiscal Year: 2013
    ..of IL-25 on colonic epithelial permeability;and 4) Determine the direct effects of IL-25 on colonic smooth muscle contraction. Specific Aim 3 will determine the role of IL-25 in colonic inflammation...
  34. HTS for Regulated Muscle Thin Filament Function.
    JAMES DOUGLAS POTTER; Fiscal Year: 2010
    ..of sarcomeric gene mutations in cardiomyopathies is their ability to alter the calcium regulation of cardiac muscle contraction. In general, the Ca2+ sensitivity of contraction decreases in dilated (DCM) cardiomyopathy;whereas, in ..
  35. The Role of Cardiomyopathic Troponin C Mutations in Skeletal and Cardiac Muscle C
    Jose Renato Pinto; Fiscal Year: 2011
    ..that attaches the complex to the thin filament;cardiac troponin I (CTnI), involved in the inhibition of muscle contraction and cardiac/slow skeletal troponin C (CTnC), that binds Ca2+ and triggers contraction...
  36. IDO Regulation in the SIV Model of HIV CNS Disease
    M Christine Zink; Fiscal Year: 2013
    ..memory and learning, temperature regulation, mood, behavior, as well as systemic cardiovascular function, muscle contraction, and endocrine regulation...
  37. Excitation contraction coupling in bladder smooth muscle
    Robert S Moreland; Fiscal Year: 2013
    ..hypothesis that protein kinase C is an integral part of the signaling in the regulation of bladder smooth muscle contraction and that specific isoforms of protein kinase C are involved in specific steps in this signaling...
  38. Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC Mutations
    Danuta Szczesna-Cordary; Fiscal Year: 2012
    ..and nano-fluorescence spectroscopy will enable us to successfully answer important questions regarding the molecular basis of FHC-mediated pathology in the heart and the role of RLC and ELC in cardiac muscle contraction.
  39. Control of motility in the internal anal sphincter
    Kathleen D Keef; Fiscal Year: 2013
    ..The proposed study will provide new insights into the mechanisms which control muscle contraction and hence anal pressure...
  40. p38 MAPK a regulator of muscle contraction and function
    Zhen Yan; Fiscal Year: 2013
    ....
  41. Endothelin and Angiotensin Receptor Signaling in Pulmonary Hypertension
    PETER RUDOLPH POLGAR; Fiscal Year: 2013
    ..4) The studies on smooth muscle contraction in culture will be followed up with physiological experiments using rats...
  42. Modulation of calcium signaling by changes in STIM expression
    Jonathan Soboloff; Fiscal Year: 2013
    ..pathways regulating a wide variety of responses ranging from rapid events such as membrane fusion and muscle contraction to control of proliferation, differentiation and apoptosis...
  43. Androgen targets in a simple behavioral system
    Cynthia L Jordan; Fiscal Year: 2013
    ..To achieve this goal, we propose to assess muscle contraction kinetics and synaptic strength, parameters that have not been assessed in any KD model, using standard in ..
  44. Neuronal-Specific Splicing of CaV1.2 L-type Calcium Channels
    Kristin Webster; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): L-type CaV1.2 voltage-gated calcium channels are essential for mediating muscle contraction, hormone release from endocrine cells, and activity-dependent gene expression in neurons...
  45. Mechanisms of Regulation Of NHE-1
    John R Raymond; Fiscal Year: 2012
    ..to public health in that NHE-1 is involved in the regulation of blood pressure, kidney function and heart muscle contraction. The work could lead to new therapies for hypertension, congestive heart failure, cardiomyopathies and ..
  46. Structure and Function of Sodium-Calcium Exchangers
    DINESH A YERNOOL; Fiscal Year: 2013
    ..These cells undergo quick, recurrent oscillations in levels of intracellular Ca2+ to achieve cardiac muscle contraction and neuronal signaling, respectively;and perturbations in NCX activity have been implicated in cardiac ..
  47. REGULATION OF MEMBRANE EXCITABILITY
    Kurt G Beam; Fiscal Year: 2012
    ..will characterize the interaction between two proteins (the "DHPR" and "RyR1") that are essential for muscle contraction. Mutations in the DHPR and RyR1 cause inherited, human muscle diseases...
  48. Targeting CaM Kinase II and Oxidative Damage in Allergic Asthma
    Howard Schulman; Fiscal Year: 2011
    ..It is characterized by reversible airflow obstruction due to bronchial smooth muscle contraction and a diseased epithelial cell phenotype of airway hyper-reactivity (AHR) to environmental stimuli, increase ..
  49. Optogenetic inhibition of motor neuron and muscle activity in vivo
    Scott L Delp; Fiscal Year: 2013
    ..potentials induced by electric nerve stimulation in a tunable and reversible manner and thereby prevent muscle contraction. Our preliminary results in anesthetized animals indicate that such inhibition is not only possible, but is ..
  50. Systems Biology Investigation of Muscle Exercise Metabolism in Diabetes
    Nicola Lai; Fiscal Year: 2013
    ..The measured responses to muscle contraction or insulin stimulations will include changes in biochemical and biotransport properties as well as ..
  51. Structural Biology of the Sodium-Calcium Exchanger
    NATHAN KYLE KARPOWICH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sodium/Calcium exchangers (NCX) play a key role in muscle contraction of cardiac myocytes in the vertebrate heart...
  52. Genetic Predisposition To Thoracic Aortic Aneurysms/Dissections
    Dianna M Milewicz; Fiscal Year: 2013
    ..of the disease, highlighting aberrant transforming growth factor-[unreadable] signaling and disrupted smooth muscle contraction as factors contributing to TAAD...
  53. Structural type 1 inositol 1,4,5-trisphosphate receptor
    Irina I Serysheva; Fiscal Year: 2010
    ..release, fertilization, hormone secretion, gene transcription, metabolic regulation, apoptosis and muscle contraction. Abnormal regulation of Ca2+ homeostasis has been implicated in numerous human diseases such as cardiac ..
  54. Tropin T and Excitation-Contraction Coupling in Aging Skeletal Muscle
    Osvaldo Delbono; Fiscal Year: 2013
    ..the Tn complex and tropomyosin (Tm) in the myoplasm, which is essential for calcium-activated striated muscle contraction. We have preliminary evidence of a nontraditional role for TnT3, the TnT isoform expressed in fast-twitch ..
  55. Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall Ischemia
    Ravinder K Mittal; Fiscal Year: 2013
    ..One of the problems is that recording of longitudinal muscle contraction with US imaging, especially over extended periods of time in humans, is quite tedious...
  56. Vevo 2100 Imaging System - High Resolution Ultrasound for Biomicroscopy
    R John Solaro; Fiscal Year: 2013
    ..to electrophysiological events and (3) accurately measure muscle contractile abnormalities or changes in muscle contraction in a user-defined region of the myocardium...
  57. Role of Cytoplasmic Actin Isoforms in the Inner Ear
    Benjamin J Perrin; Fiscal Year: 2010
    ..the most abundant proteins in nature and plays essential roles in almost every cellular function including muscle contraction, cell migration, vesicle trafficking, and polarized growth...
  58. Proteolytic Regulation of Troponin T &Cardiac Function
    Jian Ping Jin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cardiac muscle contraction is regulated by Ca2+ through the troponin complex that consists of three protein subunits: troponin C, troponin I, and troponin T (TnT)...
  59. The Role of Small Ankyrin 1 in the Sarcoplasmic Reticulum in Skeletal Muscle
    Andrew P Ziman; Fiscal Year: 2011
    ..intracellular membrane protein in skeletal muscle in organizing the stores of calcium that are necessary for muscle contraction. My studies should provide insights into the mechanisms underlying the organization of the calcium stores, ..
  60. Molecular Physiology of Myotonia and Periodic Paralysis
    Stephen C Cannon; Fiscal Year: 2013
    ..a single stimulus elicits a high- frequency burst of action potentials that produces involuntary persistent muscle contraction lasting seconds...
  61. The Role of Cardiomyopathic Troponin C Mutations in Skeletal and Cardiac Muscle C
    Jose Renato Pinto; Fiscal Year: 2013
    ..that attaches the complex to the thin filament;cardiac troponin I (CTnI), involved in the inhibition of muscle contraction and cardiac/slow skeletal troponin C (CTnC), that binds Ca2+ and triggers contraction...
  62. Restoration of Fecal Continence in Aging IAS
    Khalil N Bitar; Fiscal Year: 2012
    ..and of adult and aged rats, and examine the effect of aging on the molecular mechanisms of tonic IAS smooth muscle contraction 2) Study the role of phosphorylated-HSP27 in age-related decline of IAS smooth muscle function, and 3) ..
  63. LIPID & PROTEIN PO4 TURNOVER IN IRIS OF THE EYE
    ATA ABDEL LATIF; Fiscal Year: 2002
    ..relaxation, and the parasympathetic nervous system, which governs the generation of IP3-, DAG-, Ca2+, and muscle contraction. In addition, our studies on the interactions between these systems and the sensory nervous system, which ..
  64. MOLECULAR REGULATION OF SMOOTH MUSCLE ACTOMYOSIN
    Mitsuo Ikebe; Fiscal Year: 2004
    ..It is known that smooth muscle contraction is not proportional to the level of myosin phosphorylation...
  65. Interaction of Cardiotonic Drugs with Cardiac Troponin
    BRIAN SYKES; Fiscal Year: 2009
    ..goal of the proposed research is to elucidate the molecular mechanisms involved in the regulation of cardiac muscle contraction by troponin and to determine its role as a target for the development of therapeutic protocols that can be ..
  66. Spectroscopy of myosin light chain domain dynamics
    Osha Roopnarine; Fiscal Year: 2010
    ..determine the role of the myosin light chain (LC) domain structural dynamics in the molecular mechanism of muscle contraction, and to understand how this is altered in muscle disease, focusing on LC mutations that cause familial ..
  67. Molecular genetic analysis of UNC-82 kinase function in C. elegans muscle
    Pamela E Hoppe; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Striated muscle contraction is accomplished by a highly ordered cytoskeletal structure consisting of interdigitating actin and myosin filaments, the filament anchoring structures, and a host of ..
  68. Regulation of Vascular Smooth Muscle Contracting
    Ming Gong; Fiscal Year: 2005
    ..aim of this research is to elucidate the cellular mechanisms that mediate agonist-stimulated vascular smooth muscle contraction and relaxation...
  69. Role of Musculo-Dynamics in Bone Fluid Flow, Circulation and Adaptation
    Yi Xian Qin; Fiscal Year: 2009
    ..Exercise such as muscle contraction appears to increase blood flow to the skeletal tissues, i.e., bone and muscle...
  70. Calmodulin regulation of SR calcium release channels
    Bradley Fruen; Fiscal Year: 2007
    ..the development of novel biophysical approaches to understanding channel regulatory proteins that control muscle contraction. Muscle contraction is triggered by Ca2+ release from the sarcoplasmic reticulum (SR) via a macromolecular ..
  71. GENETIC SPECIFICATION OF NEMATODE MUSCLE
    R Anderson; Fiscal Year: 2001
    ..b>Muscle contraction is elicited with ryanodine receptors open, thereby allowing calcium stored in the sarcoplasmic reticulum to ..
  72. ORPHANIN FQ (OFQ) EFFECTS ON RAT COLONIC MOTILITY
    Toku Takahashi; Fiscal Year: 2003
    ..Inhibition of this inhibitory neural pathway will result in colonic muscle contraction and accelerates colonic transit...
  73. NMR STUDIES OF TROPONIN COMPLEX
    PAUL ROSEVEAR; Fiscal Year: 2000
    ..to determine structural interactions between cardiac troponin proteins responsible for regulation of heart muscle contraction. The central hypothesis is that a detailed structural understanding of the interactions between troponin ..