bone density

Summary

Summary: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by photon absorptiometry or x-ray computed tomography.

Top Publications

  1. pmc Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    Karol Estrada
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:491-501. 2012
  2. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
  3. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
  4. ncbi Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute and University of California, San Francisco, San Francisco, CA, USA
    N Engl J Med 361:756-65. 2009
  5. pmc osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
  6. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Lynn M Boyden
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    N Engl J Med 346:1513-21. 2002
  7. pmc Osteoporosis: now and the future
    Tilman D Rachner
    Division of Endocrinology, Diabetes, and Bone Diseases, Dresden Technical University Medical Centre, Dresden, Germany
    Lancet 377:1276-87. 2011
  8. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
  9. ncbi A reference standard for the description of osteoporosis
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, UK
    Bone 42:467-75. 2008
  10. ncbi Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis
    P Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Osteoporos Int 18:427-44. 2007

Detail Information

Publications312 found, 100 shown here

  1. pmc Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    Karol Estrada
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:491-501. 2012
    ..3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility...
  2. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
    ..These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity...
  3. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
    ..These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass...
  4. ncbi Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute and University of California, San Francisco, San Francisco, CA, USA
    N Engl J Med 361:756-65. 2009
    ..RANKL) that blocks its binding to RANK, inhibiting the development and activity of osteoclasts, decreasing bone resorption, and increasing bone density. Given its unique actions, denosumab may be useful in the treatment of osteoporosis.
  5. pmc osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
    ..Adolescent and adult OPG-/- mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bone porosity, marked thinning of the parietal bones of the ..
  6. ncbi High bone density due to a mutation in LDL-receptor-related protein 5
    Lynn M Boyden
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    N Engl J Med 346:1513-21. 2002
    ..Loss-of-function mutations in the gene for low-density lipoprotein receptor-related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause osteoporosis-pseudoglioma...
  7. pmc Osteoporosis: now and the future
    Tilman D Rachner
    Division of Endocrinology, Diabetes, and Bone Diseases, Dresden Technical University Medical Centre, Dresden, Germany
    Lancet 377:1276-87. 2011
    ..This overview discusses these novel therapies and explains their underlying physiology...
  8. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
    ..However, new and more effective approaches are likely to emerge from a better understanding of the regulators of bone cell function...
  9. ncbi A reference standard for the description of osteoporosis
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, UK
    Bone 42:467-75. 2008
    ..5 SD or more below the average for young adult women. The adoption of DXA as a reference standard provides a platform on which the performance characteristics of less well established and new methodologies can be compared...
  10. ncbi Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis
    P Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Osteoporos Int 18:427-44. 2007
    ..Diabetes affects bone metabolism. The hypothesis was that type 1 (T1D) and type 2 (T2D) affects BMD and fracture risk differently...
  11. ncbi Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus
    M Saito
    Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Osteoporos Int 21:195-214. 2010
    ..In this review, we describe age-related changes in collagen cross-links in bone and abnormalities of cross-links in osteoporosis and diabetes that have been reported in the literature...
  12. ncbi Sympercents: symmetric percentage differences on the 100 log(e) scale simplify the presentation of log transformed data
    T J Cole
    Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH, UK
    Stat Med 19:3109-25. 2000
    ..The term sympercent or s% is proposed for them. Sympercents should improve the presentation of log transformed data and lead to a wider understanding of the natural log transformation...
  13. ncbi Diagnosis of osteoporosis and assessment of fracture risk
    John A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield S10 2RX, UK
    Lancet 359:1929-36. 2002
    ..Many treatments can be provided cost-effectively to men and women if hip fracture probability over 10 years ranges from 2% to 10% dependent on age...
  14. ncbi Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
    M K Javaid
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Lancet 367:36-43. 2006
    ..We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth...
  15. ncbi Mechanisms of disease: is osteoporosis the obesity of bone?
    Clifford J Rosen
    The Jackson Laboratory in Bar Harbor, ME 04401, USA
    Nat Clin Pract Rheumatol 2:35-43. 2006
    ....
  16. ncbi The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
    ....
  17. ncbi Osteocyte regulation of bone mineral: a little give and take
    G J Atkins
    Bone Cell Biology Group, Discipline of Orthopaedics and Trauma, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
    Osteoporos Int 23:2067-79. 2012
    ..The sheer number of osteocytes in bone means that "a little give and take" in terms of regulation of bone mineral content translates into a powerful whole organism effect...
  18. pmc 'Sink or swim': an evaluation of the clinical characteristics of individuals with high bone mass
    C L Gregson
    Musculoskeletal Research Unit, University of Bristol, Bristol, UK
    Osteoporos Int 23:643-54. 2012
    ..Cases could not float, had mandible enlargement, extra bone, broad frames, larger shoe sizes and increased body mass index (BMI). HBM cases may harbour an underlying genetic disorder...
  19. ncbi Teriparatide or alendronate in glucocorticoid-induced osteoporosis
    Kenneth G Saag
    University of Alabama at Birmingham, Birmingham 35294 3408, USA
    N Engl J Med 357:2028-39. 2007
    ..Studies of anabolic therapy in patients who are receiving long-term glucocorticoids and are at high risk for fracture are lacking...
  20. ncbi Body mass index as a predictor of fracture risk: a meta-analysis
    C de Laet
    Scientific Institute of Public Health, Brussels, Belgium
    Osteoporos Int 16:1330-8. 2005
    ..The significance of BMI as a risk factor varies according to the level of BMI. Its validation on an international basis permits the use of this risk factor in case-finding strategies...
  21. ncbi Stimulation of bone formation in vitro and in rodents by statins
    G Mundy
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA
    Science 286:1946-9. 1999
    ..Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis...
  22. ncbi Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy
    David L Kendler
    Clinical Research Centre, Vancouver, British Columbia, Canada
    J Bone Miner Res 25:72-81. 2010
    ..Transition to denosumab produced greater increases in BMD at all measured skeletal sites and a greater reduction in bone turnover than did continued alendronate with a similar safety profile in both groups...
  23. ncbi Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial
    Dennis M Black
    San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
    JAMA 296:2927-38. 2006
    ..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain...
  24. ncbi Fat and bone
    Ian R Reid
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Arch Biochem Biophys 503:20-7. 2010
    Body weight is a principal determinant of bone density and fracture risk, and adipose tissue mass is a major contributor to this relationship...
  25. ncbi Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women
    Dana Bliuc
    Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
    JAMA 301:513-21. 2009
    ..There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture...
  26. pmc Update in vitamin D
    John S Adams
    UCLA Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095 7358, USA
    J Clin Endocrinol Metab 95:471-8. 2010
    ....
  27. ncbi Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review
    Todd T Brown
    Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
    AIDS 20:2165-74. 2006
    ..Prevalence estimates of osteopenia and osteoporosis (reduced bone mineral density; BMD) in HIV-infected patients and the role of antiretroviral therapy (ART) varies in the literature...
  28. ncbi Severely suppressed bone turnover: a potential complication of alendronate therapy
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 90:1294-301. 2005
    ..Our observations emphasize the need for increased awareness and monitoring for the potential development of excessive suppression of bone turnover during long-term alendronate therapy...
  29. ncbi Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial
    Jacques P Brown
    Laval University, Le Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    J Bone Miner Res 24:153-61. 2009
    ..Denosumab showed significantly larger gains in BMD and greater reduction in bone turnover markers compared with alendronate. The overall safety profile was similar for both treatments...
  30. ncbi Bone mineral accrual from 8 to 30 years of age: an estimation of peak bone mass
    Adam D G Baxter-Jones
    College of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Bone Miner Res 26:1729-39. 2011
    ..Depending on the skeletal site, peak bone mass occurs by the end of the second or early in the third decade of life. The data substantiate the importance of the circumpubertal years for accruing bone mineral...
  31. ncbi Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatment
    Paul Roschger
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, 1140 Vienna, Austria
    J Bone Miner Res 25:891-900. 2010
    ..Taken together, these data provide evidence that the investigated bone quality determinants at tissue level were preserved in postmenopausal osteoporotic women after 3-year treatment with 2 g SrR per day plus calcium and vitamin D...
  32. pmc Dual energy X-Ray absorptiometry body composition reference values from NHANES
    Thomas L Kelly
    Hologic, Inc, Bedford, Massachusetts, USA
    PLoS ONE 4:e7038. 2009
    ....
  33. ncbi Androgens and bone
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Rev 25:389-425. 2004
    ..In conclusion, androgens may protect men against osteoporosis via maintenance of cancellous bone mass and expansion of cortical bone. Such androgen action on bone is mediated by the AR and ERalpha...
  34. ncbi Osteoporosis in patients with diabetes mellitus
    Lorenz C Hofbauer
    Division of Gastroenterology and Endocrinology, Department of Medicine, Philipps University, Marburg, Germany
    J Bone Miner Res 22:1317-28. 2007
    ..Patients with type 2 diabetes mellitus may additionally benefit from early visual assessment, regular exercise to improve muscle strength and balance, and specific measures for preventing falls...
  35. ncbi Body composition of a young, multiethnic, male population
    K J Ellis
    US Department of Agriculture, Agricultural Research Service, Children s Nutrition Research Center, Houston, TX 77030 2600, USA
    Am J Clin Nutr 66:1323-31. 1997
    ..We conclude that reference values of total body composition for young healthy males need to be ethnic specific...
  36. ncbi Effects of calcium and vitamin D supplementation on hip bone mineral density and calcium-related analytes in elderly ambulatory Australian women: a five-year randomized controlled trial
    Kun Zhu
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    J Clin Endocrinol Metab 93:743-9. 2008
    ..Effects of long-term calcium, with or without vitamin D, on hip bone mineral density (BMD) and bone turnover in sunny climates have not been reported...
  37. ncbi Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial
    Björn Svensson
    University of Lund, Lund, Sweden
    Arthritis Rheum 52:3360-70. 2005
    ..To assess the efficacy of low-dose prednisolone on joint damage and disease activity in patients with early rheumatoid arthritis (RA)...
  38. ncbi Sporadic and MEN1-related primary hyperparathyroidism: differences in clinical expression and severity
    Cristina Eller-Vainicher
    Unit of Endocrinology Diabetology, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy
    J Bone Miner Res 24:1404-10. 2009
    ..Normal PTH levels and young age are associated with MEN1 presence...
  39. ncbi A systematic review of the impact of n-3 fatty acids in bone health and osteoporosis
    Pooneh Salari
    Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Med Sci Monit 14:RA37-44. 2008
    ..The authors believe that conclusive findings in humans are still lacking in this area and it needs to be further investigated...
  40. ncbi Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass
    Michael R McClung
    Oregon Osteoporosis Center, Providence Portland Medical Center, Portland, OR 97213, USA
    Arch Intern Med 165:1762-8. 2005
    ..We contrasted the effects of once-daily doses of 20 mug of teriparatide and 10 mg of alendronate sodium on bone mineral density (BMD) and markers of bone turnover...
  41. pmc An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits
    Yi Hsiang Hsu
    Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Genet 6:e1000977. 2010
    ....
  42. ncbi Older women with diabetes have an increased risk of fracture: a prospective study
    A V Schwartz
    Department of Epidemiology, Division of Endocrinology, University of California San Francisco, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 86:32-8. 2001
    ..94; 95% CI, 1.24-3.02) fractures in multivariate models controlling for age, body mass index, bone density, and other factors associated with fractures and diabetes...
  43. pmc Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis
    Yoon K Loke
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    CMAJ 180:32-9. 2009
    Rosiglitazone and pioglitazone may increase the incidence of fractures. We aimed to determine systematically the risk of fractures associated with thiazolidinedione therapy and to evaluate the effect of the therapy on bone density.
  44. pmc Population genomics in a disease targeted primary cell model
    Elin Grundberg
    Department of Human Genetics, McGill University, Montreal H3A 1B1, Canada
    Genome Res 19:1942-52. 2009
    ..5, P = 2.6 x 10(-15)). Our results suggest that primary cells relevant to disease phenotypes complement traditional approaches for prioritization and validation of GWAS hits for follow-up studies...
  45. pmc Bone disease in HIV infection: a practical review and recommendations for HIV care providers
    Grace A McComsey
    Department of Pediatrics and Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Clin Infect Dis 51:937-46. 2010
    ..We also discuss the importance of considering secondary causes of osteoporosis. Finally, we discuss treatment of the more severe cases of bone disease, while outlining the caveats and gaps in our knowledge...
  46. ncbi Maternal vitamin D status determines bone variables in the newborn
    H T Viljakainen
    Department of Applied Chemistry and Microbiology, Division of Nutrition, P O Box 66, University of Helsinki, FI 00014 Helsinki, Finland
    J Clin Endocrinol Metab 95:1749-57. 2010
    ..Maternal vitamin D status may program neonatal skeletal development. The objective here was to determine the association of mothers' vitamin D status with bone variables of their newborns...
  47. ncbi Early-onset, progressive, frequent, extensive, and severe bone mineral and renal complications in multiple endocrine neoplasia type 1-associated primary hyperparathyroidism
    Delmar M Lourenço
    Endocrine Genetics Unit LIM 25, Division of Endocrinology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    J Bone Miner Res 25:2382-91. 2010
    ..These data should be considered in the individualized clinical/surgical management of patients with MEN1-associated HPT...
  48. pmc Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice
    Hava Gil-Henn
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06511, USA
    J Cell Biol 178:1053-64. 2007
    ..These experiments underscore an important role of Pyk2 in microtubule-dependent podosome organization, bone resorption, and other osteoclast functions...
  49. ncbi Older men with low serum estradiol and high serum SHBG have an increased risk of fractures
    Dan Mellstrom
    Center for Bone Research, Sahlgrenska Academy, Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden
    J Bone Miner Res 23:1552-60. 2008
    ..3 pg/ml for fE2. In conclusion, older Swedish men with low serum E2 and high SHBG levels have an increased risk of fractures...
  50. ncbi Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    Xiaodong Li
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California 91320 1799, USA
    J Bone Miner Res 23:860-9. 2008
    ..Based on these data, sclerostin has emerged as a key negative regulator of bone mass. We generated SOST knockout (KO) mice to gain a more detailed understanding of the effects of sclerostin deficiency on bone...
  51. ncbi Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    Xiaodong Li
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California 91320 1799, USA
    J Bone Miner Res 24:578-88. 2009
    ....
  52. ncbi Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
    R G G Russell
    Nuffield Department of Orthopaedic Surgery, Oxford University Institute of Musculoskeletal Sciences The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
    Osteoporos Int 19:733-59. 2008
    ..There is new knowledge about how they work. The differences that exist among individual BPs in terms of mineral binding and biochemical actions may explain differences in their clinical behavior and effectiveness...
  53. ncbi A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    Yoon Shin Cho
    Center for Genome Science, National Institute of Health, Seoul, Korea
    Nat Genet 41:527-34. 2009
    ..On chromosome 7q31, rs7776725 (within the FAM3C gene) was associated with bone density at the radius (P = 1.0 x 10(-11)), tibia (P = 1.6 x 10(-6)) and heel (P = 1.9 x 10(-10))...
  54. pmc Regulation of osteoblastogenesis and bone mass by Wnt10b
    Christina N Bennett
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Proc Natl Acad Sci U S A 102:3324-9. 2005
    ..Finally, Wnt10b-/- mice have decreased trabecular bone and serum osteocalcin, confirming that Wnt10b is an endogenous regulator of bone formation...
  55. pmc A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
    Vijay K Yadav
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 138:976-89. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  56. pmc 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada
    Jacques P Brown
    Division of Rheumatology, Centre de Recherche du CHUL, Universite Laval, Canada
    CMAJ 167:S1-34. 2002
    ....
  57. pmc Height adjustment in assessing dual energy x-ray absorptiometry measurements of bone mass and density in children
    Babette S Zemel
    The Children s Hospital of Philadelphia, 3535 Market Street, Room 1560, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 95:1265-73. 2010
    ..No consensus exists on how to adjust BMC or BMD (BMC/BMD) measurements for short or tall stature...
  58. ncbi Epidemiology, etiology, and diagnosis of osteoporosis
    Nancy E Lane
    Aging Center, Medicine and Rheumatology, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Am J Obstet Gynecol 194:S3-11. 2006
    ..factor of these measurements is not defined clearly, and these findings should not be used as a replacement for bone density testing...
  59. pmc Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies
    Lili Ma
    Department of Rheumatology, Fudan University, Shanghai, China
    Eur J Epidemiol 27:319-32. 2012
    ..We conclude that individuals with T2DM from both genders have higher BMD levels, but that multiple factors influence BMD in individuals with T2DM...
  60. pmc The laboratory rat as an animal model for osteoporosis research
    Pavlos P Lelovas
    Laboratory for Research of the Musculoskeletal System, School of Medicine, University of Athens, Greece
    Comp Med 58:424-30. 2008
    ....
  61. ncbi American College of Sports Medicine Position Stand: physical activity and bone health
    Wendy M Kohrt
    Med Sci Sports Exerc 36:1985-96. 2004
  62. ncbi Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards
    S Vasikaran
    Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia
    Osteoporos Int 22:391-420. 2011
    ....
  63. ncbi Comparison of changes in bone density and turnover with abacavir-lamivudine versus tenofovir-emtricitabine in HIV-infected adults: 48-week results from the ASSERT study
    Hans Jurgen Stellbrink
    Infektions Medizinisches Centrum Hamburg Study Center, Hamburg, Germany
    Clin Infect Dis 51:963-72. 2010
    ..Abacavir-lamivudine and tenofovir DF-emtricitabine fixed-dose combinations are commonly used as first-line antiretroviral therapies. However, few studies have comprehensively compared their relative safety profiles...
  64. pmc Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107 1762, USA
    JAMA 305:2184-92. 2011
    ..It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM...
  65. ncbi Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
    Roger M D Zebaze
    Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
    Lancet 375:1729-36. 2010
    ..We aimed to re-examine cortical bone as a source of bone loss in the appendicular skeleton...
  66. ncbi Association between oxidative stress and bone mineral density
    S Basu
    Sections of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S 751 25 Uppsala, Sweden
    Biochem Biophys Res Commun 288:275-9. 2001
    ..Our findings establish a biochemical link between increased oxidative stress and reduced bone density and provide a rational for further studies investigating the role of pro- and antioxidants in osteoporosis.
  67. ncbi Requirements for DXA for the management of osteoporosis in Europe
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 16:229-38. 2005
    ..The total direct costs were estimated at 31.7 billion Euros (21.165 billion UK pounds), which were expected to increase to 76.7 billion Euros (51.1 billion UK pounds) in 2050 based on the expected changes in the demography of Europe...
  68. ncbi Interpretation and use of FRAX in clinical practice
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Osteoporos Int 22:2395-411. 2011
    ..Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this review..
  69. pmc Bone mineral density in HIV-negative men participating in a tenofovir pre-exposure prophylaxis randomized clinical trial in San Francisco
    Albert Y Liu
    San Francisco Department of Public Health, San Francisco, California, United States of America
    PLoS ONE 6:e23688. 2011
    ..We determined the baseline prevalence of low bone mineral density (BMD) and the effect of TDF on BMD in men who have sex with men (MSM) in a PrEP trial in San Francisco...
  70. pmc Habitual levels of vigorous, but not moderate or light, physical activity is positively related to cortical bone mass in adolescents
    A Sayers
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 96:E793-802. 2011
    ..The intensity of habitual physical activity (PA) needed to affect skeletal development in childhood is currently unclear...
  71. pmc Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis
    Charles R Farber
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Genet 7:e1002038. 2011
    ..This study identifies a new regulator of BMD and osteoclastogenesis and highlights the power of GWA and systems genetics in the mouse for dissecting complex genetic traits...
  72. ncbi Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use
    Anthony B Hodsman
    University of Western Ontario, St Joseph s Health Care, Room 2F 15, 268, Grosvenor Street, London, Ontario N6A 4V2, Canada
    Endocr Rev 26:688-703. 2005
    ..At present, concurrent therapy with antiresorptive therapy, particularly bisphosphonates, should be avoided, although sequential therapy with such agents may consolidate the beneficial effects upon the skeleton after PTH is discontinued...
  73. ncbi Relationships between fat and bone
    I R Reid
    University of Auckland, Auckland, New Zealand
    Osteoporos Int 19:595-606. 2008
    Body weight impacts both bone turnover and bone density, making it, therefore, an important risk factor for vertebral and hip fractures and ranking it alongside age in importance...
  74. ncbi Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
    Heike A Bischoff-Ferrari
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 84:18-28. 2006
    ..The implications of higher doses for the entire adult population should be addressed in future studies...
  75. pmc Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
    David G Winkler
    Department of Gene Function and Target Validation, Celltech R and D, Inc, Bothell, WA 98021, USA
    EMBO J 22:6267-76. 2003
    ..Modulation of this osteocyte-derived negative signal is therapeutically relevant for disorders associated with bone loss...
  76. pmc Bone mineral density and fractures in antiretroviral-naive persons randomized to receive abacavir-lamivudine or tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG
    Grace A McComsey
    Departments of Pediatrics and Medicine, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    J Infect Dis 203:1791-801. 2011
    ..Long-term effects of abacavir (ABC)-lamivudine (3TC), compared with tenofovir (TDF)-emtricitabine (FTC) with efavirenz (EFV) or atazanavir plus ritonavir (ATV/r), on bone mineral density (BMD) have not been analyzed...
  77. ncbi The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography
    G Boivin
    Inserm Unite 403, Faculté de Médecine R Laennec, 69372 Lyon Cedex 08, France
    Calcif Tissue Int 70:503-11. 2002
    ..A control MDMB, which does not change with age, and a control distribution of these values are thus established. These control values are necessary for interpreting the changes in MDMB observed in bone conditions untreated or treated...
  78. pmc Caloric restriction leads to high marrow adiposity and low bone mass in growing mice
    Maureen J Devlin
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:2078-88. 2010
    ..These results support the hypothesis that caloric restriction during rapid skeletal growth is deleterious to cortical and trabecular bone mass and architecture, in contrast to potential skeletal benefits of CR in aging animals...
  79. ncbi Physical activity in childhood and bone health
    Colin A G Boreham
    Institute for Sport and Health, University College Dublin, Newstead Building, Belfield, Dublin 4, Ireland
    Br J Sports Med 45:877-9. 2011
    ..In addition, the review poses several unresolved questions in the field for future research...
  80. ncbi Guidance for the adjustment of FRAX according to the dose of glucocorticoids
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S102RX, UK
    Osteoporos Int 22:809-16. 2011
    ..A relatively simple adjustment of conventional FRAX estimates of probabilities of hip fracture and a major osteoporotic fracture can be applied to modulate the risk assessment with knowledge of the dose of glucocorticoids...
  81. ncbi Effect of denosumab on bone mineral density and biochemical markers of bone turnover: six-year results of a phase 2 clinical trial
    Paul D Miller
    Colorado Center for Bone Research, 3190 South Wadsworth Boulevard, Ste 250, Lakewood, Colorado 80227, USA
    J Clin Endocrinol Metab 96:394-402. 2011
    ..This is a study extension to evaluate the efficacy and safety of long-term treatment with denosumab in postmenopausal women with low bone mass...
  82. ncbi Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
    R M Neer
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 344:1434-41. 2001
    ..The 40-microg dose increased bone mineral density more than the 20-microg dose but had similar effects on the risk of fracture and was more likely to have side effects...
  83. ncbi Bone mineral in pre- and postmenopausal women with insulin-dependent and non-insulin-dependent diabetes mellitus
    J O Christensen
    Center for Clinical and Basic Research CCBR, Ballerup, Denmark
    Osteoporos Int 10:307-11. 1999
    ..In conclusion, postmenopausal IDDM patients have a relatively decreased BMD, whereas NIDDM patients seem to be relatively protected from postmenopausal bone loss...
  84. ncbi Microarchitectural deterioration of cortical and trabecular bone: differing effects of denosumab and alendronate
    Ego Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 25:1886-94. 2010
    ..001). Adverse events did not differ by group. These data suggest that structural decay owing to bone remodeling and progression of bone fragility may be prevented more effectively with denosumab...
  85. pmc Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk
    Emma L Duncan
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    PLoS Genet 7:e1001372. 2011
    ..In addition to identifying further genes associated with BMD, this study confirms the efficiency of extreme-truncate selection designs for quantitative trait association studies...
  86. ncbi Bone mineral density analysis in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 after total parathyroidectomy
    Flavia L Coutinho
    Endocrine Genetics Unit LIM 25, Division of Endocrinology, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Clin Endocrinol (Oxf) 72:462-8. 2010
    ..This study investigates the impact of total PTx on BMD in patients with HPT/MEN1...
  87. pmc Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents
    V Chel
    Verpleeghuis Marienhave, Warmond, The Netherlands
    Osteoporos Int 19:663-71. 2008
    ..A daily dose was more effective than a weekly dose, and a monthly dose was the least effective...
  88. ncbi Exercise interventions to reduce fall-related fractures and their risk factors in individuals with low bone density: a systematic review of randomized controlled trials
    D de Kam
    Department of Rehabilitation, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Osteoporos Int 20:2111-25. 2009
    ..The results from this systematic review indicate that exercise interventions for individuals with low BMD to reduce falls and fractures should include balance, muscle strengthening, and weight-bearing exercises...
  89. ncbi Social position affects bone mass in childhood through opposing actions on height and weight
    Emma M Clark
    Community Based Medicine, University of Bristol, United Kingdom
    J Bone Miner Res 20:2082-9. 2005
    ..9 years. The tendency for social position to increase bone area and bone mass through a positive influence on height was opposed by a negative effect of social position on weight and fat mass...
  90. ncbi Risk of fracture after androgen deprivation for prostate cancer
    Vahakn B Shahinian
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 0562, USA
    N Engl J Med 352:154-64. 2005
    ..This treatment is associated with a loss of bone-mineral density, but the risk of fracture after androgen-deprivation therapy has not been well studied...
  91. ncbi Zoledronic acid and clinical fractures and mortality after hip fracture
    Kenneth W Lyles
    Duke University Medical Center, Durham, NC, USA
    N Engl J Med 357:1799-809. 2007
    ..Mortality is increased after a hip fracture, and strategies that improve outcomes are needed...
  92. ncbi HIV and bone mineral density
    Patrick W G Mallon
    HIV Molecular Research Group, School of Medicine and Medical Sciences, University College Dublin, Ireland
    Curr Opin Infect Dis 23:1-8. 2010
    ..This review details the clinical aspects and pathogenesis of low bone mineral density (BMD) in HIV, discusses broad management issues and outlines areas in which our understanding of this condition is incomplete...
  93. ncbi The European Male Ageing Study (EMAS): design, methods and recruitment
    David M Lee
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    Int J Androl 32:11-24. 2009
    ..Such information is an important prerequisite to develop effective strategies to reduce age-related disabilities and optimise health and well-being into old-age...
  94. ncbi Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis
    Andrea M Isidori
    Cattedra di Andrologia, Universita La Sapienza, Rome, Italy
    Clin Endocrinol (Oxf) 63:280-93. 2005
    ..review of randomized controlled trials (RCTs) evaluating the effects of testosterone (T) administration to middle-aged and ageing men on body composition, muscle strength, bone density, markers of bone metabolism and serum lipid profile.
  95. ncbi Osteoporosis in children and adolescents
    Maria Luisa Bianchi
    Bone Metabolism Unit, Istituto Auxologico Italiano IRCCS Via L Ariosto 13 20145, Milano, Italy
    Bone 41:486-95. 2007
    In recent years, the issue of low bone density in children and adolescents has attracted much attention...
  96. ncbi Multiple endocrine neoplasia type 1 in Brazil: MEN1 founding mutation, clinical features, and bone mineral density profile
    D M Lourenco
    Unidade de Endocrinologia Genética, Laboratório de Investigação Médica LIM 25, Endocrinologia, Faculdade de Medicina da Universidade de Sao Paulo FMUSP, Cerqueira Cesar, Sao Paulo 01246 903, SP, Brasil
    Eur J Endocrinol 159:259-74. 2008
    ..Only few large families with multiple endocrine neoplasia type 1 (MEN1) have been documented. Here, we aimed to investigate the clinical features of a seven-generation Brazilian pedigree, which included 715 at-risk family members...
  97. pmc Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture
    J Brent Richards
    McGill University, Montreal, Quebec, Canada
    Ann Intern Med 151:528-37. 2009
    ..Osteoporosis is a highly heritable trait. Many candidate genes have been proposed as being involved in regulating bone mineral density (BMD). Few of these findings have been replicated in independent studies...
  98. pmc Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis
    Tie Lin Yang
    Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, People s Republic of China
    Am J Hum Genet 83:663-74. 2008
    ..Subjects without UGT2B17 had significantly higher concentrations of testosterone and estradiol. Our findings suggest the important contribution of CNV of UGT2B17 to the pathogenesis of osteoporosis...
  99. ncbi Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial
    Paul D Miller
    Colorado Center for Bone Research, 3190 South Wadsworth Blvd, Ste 250, Lakewood, CO 80227, USA
    Bone 43:222-9. 2008
    ..We assessed the long-term efficacy and safety of denosumab, and the effects of discontinuing and restarting denosumab treatment in postmenopausal women with low bone mass...
  100. ncbi Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:1612-7. 2005
    ..Diabetes mellitus (DM) and related complications may increase clinical fracture risk in older adults...
  101. pmc European guidance for the diagnosis and management of osteoporosis in postmenopausal women
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Osteoporos Int 19:399-428. 2008
    ..Guidance is provided in a European setting on the assessment and treatment of postmenopausal women with or at risk from osteoporosis...

Research Grants72

  1. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    ..In the interim since original submission of this proposal, the candidate completed a study on recovery of bone density and structure in children and adolescents after completion of therapy for acute lymphoblastic leukemia (..
  2. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..measures and oral radiographs for alveolar crestal height (ACH);dual energy x-ray absorptiometry (DXA) for bone density and body composition;questionnaires on lifestyle habits, oral hygiene and medical history;resting blood ..
  3. Mechanisms of Stem Cell Self-Renewal and Aging
    PAUL CHRISTIAN SCHILLER; Fiscal Year: 2013
    ..These include lower bone density and trabecular thickness, lower osteoblast and osteocytes numbers, impaired osteoblastic gene expression, ..
  4. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    ..Prx1 flox/flox X 2.3kb Cola1-Cre mice). Dynamic histomorphometry, microCT, histology, and bone density will be used. 2B...
  5. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..In order to assess the associations between ucOC and energy metabolism as well as bone density in a population of older adults, this research project will use data and biological specimens from the Health, ..
  6. Salivary-based Bone-loss Marker Detection Platform for Point-of-Care Screening
    MANAL BESHAY; Fiscal Year: 2012
    ..Although these diagnostic techniques are accurate, they are not optimal for routine screening of bone density because they are expensive, relatively time- and labor-intensive compared to point- of-care tests, and often ..
  7. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..conversion of red to yellow marrow in adolescents mirrors findings in adults indicating an associated decreased bone density and increased fracture risk...
  8. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..Specific Aim #1: total body fat, visceral fat, subcutaneous fat, muscle mass, intramyocellular lipid, bone density), cardiometabolic risk factors (Specific Aim #2: blood pressure, blood glucose, insulin, lipids, C-reactive ..
  9. Body composition, bone structure, and joint damage in rheumatoid arthritis
    Joshua F Baker; Fiscal Year: 2013
    ..function, serologic measures, and body composition measures associated with longitudinal deteriorations in ALM, bone density and structure, joint damage and disability over 2 years, and 3) To determine if lower disease activity is ..
  10. Roles of Gs Alpha and interaction with Wnt signaling in regulation of adipocyte d
    Partha S Sinha; Fiscal Year: 2011
    ..and animal research models which demonstrate an inverse relationship between bone marrow adiposity and bone density. Elucidation of the mechanisms governing how bone marrow stromal cells differentiate into adipocytes and ..
  11. FUNCTION AND REGULATION OF OSTEONECTIN IN BONE
    Anne M Delany; Fiscal Year: 2013
    ..Importantly, single nucleotide polymorphisms (SNPs) in the 3'UTR of osteonectin gene are associated with bone density in humans, and these SNPs modulate 3'UTR function...
  12. Saliva and Serum Inflammatory Biomarkers in Periodontitis: A Study in Older Women
    Jean Wactawski Wende; Fiscal Year: 2010
    ..to assess indices of oral and periodontal health (CAL, ACH, bleeding, plaque, calculus, tooth loss, DMFT, oral bone density). Assessments of bone density (DXA), body composition and other physical measures were obtained...
  13. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
    ..These potent stomach acid suppressants may reduce bone density and increase the risk of osteoporotic fractures...
  14. Stress and Subclinical Cardio-Metabolic Disease in Police: A Longitudinal Study
    John M Violanti; Fiscal Year: 2013
    ..function);and dual-energy x-ray absorptiometric (DXA) measurement of body fat, lean tissue composition, and bone density. Also to be examined are psychosocial factors known to be detrimental to health such as perceived stress, ..
  15. New Approaches to the Evaluation and Treatment of Acromegaly
    Pamela U Freda; Fiscal Year: 2013
    ..about the effects GH and IGF-I on body composition, adipose tissue inflammation, endothelial dysfunction, bone density and cardiovascular risk, which is also applicable to our understanding of the effects of GH use and over-use in ..
  16. Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on Fractures
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..provide positive or informative null results on the effects of vitamin D and omega-3 fatty acids on fractures, bone density, falls, and frailty...
  17. Regulation of PTH-induced Osteoanabolism by Inflammatory Lipids
    Yin Tintut; Fiscal Year: 2013
    ..In additional studies, we and other investigators demonstrated that hyperlipidemic mice have reduced bone density compared to WT mice...
  18. Synthesis of bone-selective osteogenic oxysterols
    Frank Stappenbeck; Fiscal Year: 2013
    ..Since the 1960's, bisphosphonate drug therapy has produced clinical benefits such as improved bone density and reduced fracture risk by slowing osteoclastic bone resorption...
  19. Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapy
    Yu Zhang; Fiscal Year: 2012
    ..levels: (a) molecular (gene expression) and cellular (osteocyte density);(b) biomechanical (bone strength, bone density);(c) microstructural (cortical and trabecular bone thickness, trabecular bone porosities, anisotropy);(d) ..
  20. Bone Marrow Adiposity, Bone and Body Composition
    Ann V Schwartz; Fiscal Year: 2012
    ..recent studies suggest that marrow fat accumulation is instead part of dynamic processes that also affect bone density and size...
  21. Rates and determinants of decreased bone health among HIV-infected patients
    Roger Bedimo; Fiscal Year: 2013
    ..Furthermore, factors associated with HCV infection that might mediate a higher risk of decreased bone density and osteoporotic fractures - either decreased formation or increased resorption - among HIV-infected patients ..
  22. The Effects of Iron Status on FGF23 Metabolism and Bone Health.
    Michael J Econs; Fiscal Year: 2012
    ..We currently have bone density measurements, completed questionnaires, serum biochemistries, blood and urine samples from over 4,000 healthy ..
  23. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2011
    ..known about the actions of estrogens in non-reproductive organs, regulating immune modulation, maintenance of bone density, cardiovascular function, behavior, learning, memory, and adipogenesis...
  24. Glucocorticoids, Bone Strength and Angiogenesis
    ROBERT STEWART WEINSTEIN; Fiscal Year: 2013
    ..Fractures may occur in 30 to 50% of patients receiving chronic glucocorticoid therapy but bone density measurements underestimate the risk of fracture in this disorder and account for, at least in part, the under- ..
  25. Early effects of PTH on the proximal femur
    Felicia Cosman; Fiscal Year: 2013
    ..Apart from the beneficial effect of TPTD on bone density and bone strength by finite element analysis at the hip, nothing is known about the mechanism of the effect of ..
  26. Coloney Stimulating Factor 1 regulation and role in bone
    KARL LEONARD INSOGNA; Fiscal Year: 2010
    ..Interestingly, while mCSF1 completely rescued the osteopetrotic phenotype of the op/p mouse, the bone density in sCSF1-op/op mice did not completely normalize...
  27. Diet by Gene Interactions Affecting Calcium and Bone Metabolism
    James C Fleet; Fiscal Year: 2010
    ..We will use the BXD RI panel to characterize the response of bone density and intestinal calcium absorption to dietary calcium restriction...
  28. Fractures, Heart Disease, and Stroke on Aromatase Inhibitors
    Nancy L Keating; Fiscal Year: 2010
    ..In addition, we will examine whether women treated with aromatase inhibitors are receiving recommended bone density testing...
  29. Mechanistic basis of probiotic prevention of osteoporosis
    Narayanan Parameswaran; Fiscal Year: 2013
    ..Intestine-bone signaling is demonstrated to contribute to the regulation of bone density, yet very little is known about how menopause impacts the intestine and the role that this could play in bone ..
  30. The Effects of CFTR Dysfunction on Bone Formation
    Marie E Egan; Fiscal Year: 2012
    ..Low bone density and increased fracture rates in CF are well-documented but poorly understood...
  31. The interaction of anabolic and antiresorptive agents in osteoporosis therapy
    Joy Tsai; Fiscal Year: 2013
    ..effects of combination TPTD and DMAB therapy versus each individual agent on cortical and trabecular volumetric bone density, cortical thickness and porosity, trabecular microarchitecture, and estimated bone strength (via micro finite ..
  32. Clinical Validation of BCT - Phase II
    DAVID KOPPERDAHL; Fiscal Year: 2010
    ..of a bone fracture that accounts for such factors as the patient's 3D bone geometry and distribution of bone density, body-weight, height, trochanteric soft tissue thickness (for hip fractures), muscle moment arm (for spine), ..
  33. Assessing and modifying bone quality in chronic kidney disease
    Chris Newman; Fiscal Year: 2013
    ..Primary outcomes will be determined by skeletal analyses (histology, microCT, bone density, mechanical testing, and bone quality measures), though the biochemical, renal, and vascular components of CKD-..
  34. Genetics of IGF1 and Bone Density: The Role of Nocturnin
    CLIFFORD JAMES ROSEN; Fiscal Year: 2012
    ..We were successful in identifying the strongest QTL for IGF-I and bone density on mouse Chr6, and made a congenic mouse (6T) that carried this locus from C3H, on a B6 background...
  35. Mid-Atlantic Nutrition Obesity Research Center
    Alan R Shuldiner; Fiscal Year: 2013
    ..Additionally, researchers address the genetic and environmental control of bone density and stroke risk and translational research to examine genetic and nutritional factors that increase risk of, ..
  36. Targeted Stem Cell Therapy Coupling Angiogenesis and Osteogenesis for Bone Defect
    Selvarangan Ponnazhagan; Fiscal Year: 2013
    ..approach, we recently demonstrated that MSC, genetically-engineered to produce BMP2, significantly improved bone density during first few months in a mouse model of osteoporosis...
  37. Targeted Sequencing of 3 Loci Associated with BMD in the Framingham Osteoporosis
    Douglas P Kiel; Fiscal Year: 2012
    ..power to be able to detect low frequency and rare variants that are likely to be the ones that affect bone density phenotypes...
  38. Maintenance of Skeletal Integrity in Frail Elders
    Susan L Greenspan; Fiscal Year: 2013
    ..Outcome measures will include bone density of the spine and hip, markers of bone turnover, vertebral x rays to assess for fractures and adverse events...
  39. Testerone Trial
    Peter J Snyder; Fiscal Year: 2013
    ..Subsets of men will be assessed for cardiovascular disease by electron beam CT;volumetric bone density of the spine by quantitative CT;and anemia...
  40. Vitamin D and Osteoporosis Prevention in Elderly African Americans
    John F Aloia; Fiscal Year: 2013
    ..Adequate calcium intake will be ensured. Functional markers of vitamin D including bone density, serum PTH, and bone turnover will be measured...
  41. Risk Factors for Osteoporosis in Children &Adolescents with Myelomeningocele
    Tishya A L Wren; Fiscal Year: 2013
    ..The specific aims are (1) to examine longitudinal changes in bone density, size, and structural (strength) properties in children and adolescents with MM and to compare these changes ..
  42. Dietary and serum phytoestrogens and women's health conditions in midlife
    Gail A Greendale; Fiscal Year: 2012
    ..of the relations between plant estrogen consumption and 4 outcomes that are important to the health of women: bone density, hot flashes, urinary incontinence and cognitive performance...
  43. Postmenopausal Monkey Resource
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..temperature, cognitive function, brain structure, immune function, fat accumulation, glucose metabolism and bone density. We will obtain postmortem assessments of coronary arteries, breast tissue, fat insulin sensitivity, and ..
  44. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2012
    ..known about the actions of estrogens in non-reproductive organs, regulating immune modulation, maintenance of bone density, cardiovascular function, behavior, learning, memory, and adipogenesis...
  45. Effect of Osteoporosis on Spine Fusion
    BRIAN CROCKETT COOLEY; Fiscal Year: 2010
    ..Osteonectin-null mice have reduced numbers of both osteoblasts and osteoclasts, with a net reduction in bone density (i.e., osteoporosis)...
  46. Natural history of bone disease and the impact of growth hormone treatment in MPS
    LYNDA ELIZABETH POLGREEN; Fiscal Year: 2013
    ..short stature with a Phase 2/3 randomized controlled trial design;2) To develop a registry of bone development (bone density, geometry, and estimated strength) and endocrine function in children with MPS I, II, and VI using a 3-year ..
  47. Pathophysiology and diagnosis of neurological pain syndromes
    Anne Louise Oaklander; Fiscal Year: 2012
    ..In Aim 2 these same patients will be offered ultrasound tests of heel-bone density to test the hypothesis that small-fiber polyneuropathies also cause bone loss...
  48. Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
    Martin A Freilich; Fiscal Year: 2010
    ..of bone augmentation followed by dental implant placement in postmenopausal women with normal to osteoporotic bone density;and 2) To explore potential associations between bone health parameters (e.g...
  49. Mechanical stress and skeletal plasticity after spinal cord injury in humans
    Richard K Shields; Fiscal Year: 2013
    ..Aim 1 will determine the effects of a prescribed dose of mechanical load on bone density of the tibia over 1 year following SCI...
  50. Vitamin D, falls, fractures and function in community-dwelling older adults
    Stephen Kritchevsky; Fiscal Year: 2009
    ..its associated secondary hyperparathyroidism accelerates the disablement process not only through effects on bone density and fractures but also through direct effects on muscular function which we hypothesize lead to higher rates of ..
  51. The role of the atypical PKCs in osteoclast function
    JULIA THERESE WARREN; Fiscal Year: 2013
    ..is a skeletal disease characterized by excess bone resorption relative to bone formation, leading to decreased bone density and increased risk for fracture...
  52. Physical Activity to Modify Sequelae and QOL in Childhood ALL: A Nursing Trial
    Cheryl Lorane Cox; Fiscal Year: 2013
    ..of motion, and gross and fine motor function;reduced energy expenditure, fitness, bone mineral content, and bone density;and decreased health-related quality of life (HRQL);2) long-term effects of therapy include persistent fatigue; ..
  53. HIV and Adiposity in Women: Effects on Bone Metabolism
    Anjali Sharma; Fiscal Year: 2013
    ..a prospective study which performs rigorous metabolic testing including DXA scans to quantify regional fat and bone density measurements...
  54. BOTANICAL CENTER FOR AGE-RELATED DISEASES
    Connie M Weaver; Fiscal Year: 2010
    ..to biochemical markers of bone turnover and traditional calcium kinetics, rapid compared to studying changes in bone density, and not invasive as is bone histomorphometry...
  55. FSH as a biomarker of bone strength in younger postmenopausal women
    Margaret L Gourlay; Fiscal Year: 2010
    ..Associations between FSH-related variables and low bone density have been reported in animal models and a cohort study of pre- and perimenopausal women;however, no study to ..
  56. Nutritional Regulation of bone
    SUE AMY SHAPSES; Fiscal Year: 2012
    ..It is currently not known how a high pro diet affects bone density or quality during CR...
  57. Phase 2 of Growth Hormone for Treatment of Albright Hereditary Osteodystrophy
    Emily L Germain-Lee; Fiscal Year: 2013
    ..to increased growth velocities, taller adult heights, decreased BMI and adiposity, and improvements in lipids, bone density, sense of well-being, and self-esteem without any significant side effects from GH use...
  58. CHANGES IN SKELETAL MICROARCHITECTURE FOLLOWING RENAL TRANSPLANTATION
    MARY BETH LEONARD; Fiscal Year: 2011
    ..trabecular network connectivity will not recover after transplantation, and (5) QCT measures of cortical bone density and dimensions and (MRI estimates of trabecular connectivity will predict vertebral deformities and fractures...
  59. Structural and functional characterization of the receptor protein tyrosine phosp
    Heidi Erlandsen; Fiscal Year: 2010
    ..might be able to treat osteoarthritis, osteopenia/osteoporosis, and other diseases associated with changes in bone density. PUBLIC HEALTH RELEVANCE: The receptor protein tyrosine phosphatase [unreadable]?? ?(RPTP[unreadable]? ) is a ..
  60. Effects of Anorexia Nervosa on Peak Bone Mass
    Anne Klibanski; Fiscal Year: 2013
    ..Low bone density is a frequent complication of adolescents with AN, and is concerning for increased fracture risk...
  61. Characterization of a novel T cell activating protein in arthritis
    Raphael Hirsch; Fiscal Year: 2013
    ..on joint structure at birth and during development to adulthood, bone formation and architecture, bone density and strength, and cartilage integrity. The second Aim is to determine the contribution of FSTL-1 to arthritis...
  62. Regulation of Osteoblast Differentiation by Delta FosB
    ROLAND E BARON; Fiscal Year: 2012
    ..is to further understand the molecular mechanisms by which a transcription factor called (FosB increases bone density in adult mice...
  63. OSTEOARTHRITIS & OSTEOPOROSIS IN ELDERLY WOMAN
    Michael Nevitt; Fiscal Year: 1992
    ..Whether increased bone density is a pathogenic factor in the development of OA is uncertain...
  64. Expandable Shape-Memory Polymers for Suture Anchors
    Christopher M Yakacki; Fiscal Year: 2011
    ..Patients with poor bone mass densities are highly at risk of device failure as bone density have been correlated to the fixation strength of the suture anchors...
  65. Clinical Validation of BCT
    DAVID KOPPERDAHL; Fiscal Year: 2007
    ..of a bone fracture that accounts for such factors as the patient's 3D bone geometry and distribution of bone density, body-weight, height, trochanteric soft tissue thickness (for hip fractures), and age, thereby shifting focus ..
  66. REPRODUCTIVE DEVELOPMENT & BONE ACCRETION IN YOUNG WOMEN
    Thomas Lloyd; Fiscal Year: 1999
    ..Recent studies have confirmed that 1) peak bone density is a predictor of osteoporosis risk; 2) 50% of adult bone mass in females is acquired during adolescence; and 3)..
  67. 1H MRS to diagnose bone weakening from aging /inactivity
    Dieter Schellinger; Fiscal Year: 2001
    Dual energy X-ray absorptiometry (DEXA) measures bone density which may be only one of several elements responsible for biomechanical competence...
  68. LONGITUDINAL STUDY OF BONE DENSITY IN ANOREXIA NERVOSA
    MICHAEL PERTSCHUK; Fiscal Year: 1993
    We previously identified decreased bone density as a complication of anorexia nervosa. There are serious implications to this finding...
  69. Treatment of Osteopenia in Children with Cerebral Palsy
    Richard Henderson; Fiscal Year: 2002
    ..placebo-controlled Pilot Trial to assess the safety and efficacy of intravenous bisphosphonates to treat low bone density in children with severe CP...
  70. NONINVASIVE ASSESSMENT OF TRABECULAR ARCHITECTURE
    Sharmila Majumdar; Fiscal Year: 1999
    ..In this context bone quality and strength may depend on several factors apart from bone density such as trabecular architecture...
  71. Depo-provera & BMD: Continuing Observations
    M Clark; Fiscal Year: 2005
    This is an application for a competing continuation to R01 HD39100 "Depo-provera and Bone Density in Premenopausal Women...
  72. A Novel Long-Lived 41Ca Marker To Assess Bone Turnover For Breast Cancer Patients
    Susanta Hui; Fiscal Year: 2009
    ..currently much-used method of monitoring bone mineral density (BMD) is neither sensitive to small changes in bone density, nor suitable for frequent assesments of bone density...