biological availability

Summary

Summary: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.

Top Publications

  1. ncbi Dietary ascorbate intake affects steady state tissue concentrations in vitamin C-deficient mice: tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit)
    Margreet C M Vissers
    Free Radical Research Group, University of Otago, Christchurch, New Zealand
    Am J Clin Nutr 93:292-301. 2011
  2. ncbi Molecular properties that influence the oral bioavailability of drug candidates
    Daniel F Veber
    Department of Medicinal Chemistry, GlaxoSmithKline, 709 Swedeland Road, P O Box 1539, King of Prussia, Pa 19406 0939, USA
    J Med Chem 45:2615-23. 2002
  3. ncbi Iron bioavailability and dietary reference values
    Richard Hurrell
    Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 91:1461S-1467S. 2010
  4. ncbi Nutritional iron deficiency
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Lancet 370:511-20. 2007
  5. pmc Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
  6. pmc Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations
    Anitra C Carr
    Centre for Free Radical Research, Department of Pathology, University of Otago, Christchurch, Christchurch, New Zealand
    Am J Clin Nutr 97:800-7. 2013
  7. ncbi The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    Stefan Blech
    Boehringer Ingelheim Pharma GmbH and Co KG, Department of Drug Metabolism and Pharmacokinetics, Biberach, Germany
    Drug Metab Dispos 36:386-99. 2008
  8. pmc A randomized steady-state bioavailability study of synthetic versus natural (kiwifruit-derived) vitamin C
    Anitra C Carr
    Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago, Christchurch, PO Box 4345, Christchurch 8140, New Zealand
    Nutrients 5:3684-95. 2013
  9. pmc Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process
    Min Soo Kim
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Int J Nanomedicine 6:2997-3009. 2011
  10. ncbi Evaluation of extractants for estimation of the phytoavailable trace metals in soils
    Neal W Menzies
    School of Land and Food Sciences, The University of Queensland, St Lucia, QLD 4072, Australia
    Environ Pollut 145:121-30. 2007

Detail Information

Publications297 found, 100 shown here

  1. ncbi Dietary ascorbate intake affects steady state tissue concentrations in vitamin C-deficient mice: tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit)
    Margreet C M Vissers
    Free Radical Research Group, University of Otago, Christchurch, New Zealand
    Am J Clin Nutr 93:292-301. 2011
    ..How dietary intake affects tissue concentrations is difficult to monitor and has generally been based on the measurement of plasma concentrations...
  2. ncbi Molecular properties that influence the oral bioavailability of drug candidates
    Daniel F Veber
    Department of Medicinal Chemistry, GlaxoSmithKline, 709 Swedeland Road, P O Box 1539, King of Prussia, Pa 19406 0939, USA
    J Med Chem 45:2615-23. 2002
    ..A threshold permeation rate is a prerequisite of oral bioavailability. The rotatable bond count does not correlate with the data examined here for the in vivo clearance rate in the rat...
  3. ncbi Iron bioavailability and dietary reference values
    Richard Hurrell
    Institute of Food, Nutrition and Health, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 91:1461S-1467S. 2010
    ..It would therefore be timely to develop a range of iron bioavailability factors based not only on diet composition but also on subject characteristics, such as iron status and prevalence of obesity...
  4. ncbi Nutritional iron deficiency
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
    Lancet 370:511-20. 2007
    ..Selective plant breeding and genetic engineering are promising new approaches to improve dietary iron nutritional quality...
  5. pmc Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
    ..Clinical trials in SM of adjunctive agents to improve endothelial NO bioavailability, including l-arginine, are warranted...
  6. pmc Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations
    Anitra C Carr
    Centre for Free Radical Research, Department of Pathology, University of Otago, Christchurch, Christchurch, New Zealand
    Am J Clin Nutr 97:800-7. 2013
    ..Vitamin C may also protect these metabolically active cells from oxidative stress...
  7. ncbi The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    Stefan Blech
    Boehringer Ingelheim Pharma GmbH and Co KG, Department of Drug Metabolism and Pharmacokinetics, Biberach, Germany
    Drug Metab Dispos 36:386-99. 2008
    ..o. administration of dabigatran etexilate and that the potential for clinically relevant interactions between dabigatran and drugs metabolized by cytochrome P450 is low...
  8. pmc A randomized steady-state bioavailability study of synthetic versus natural (kiwifruit-derived) vitamin C
    Anitra C Carr
    Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago, Christchurch, PO Box 4345, Christchurch 8140, New Zealand
    Nutrients 5:3684-95. 2013
    ..Overall, our study showed comparable bioavailability of synthetic and kiwifruit-derived vitamin C. ..
  9. pmc Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process
    Min Soo Kim
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Int J Nanomedicine 6:2997-3009. 2011
    ..The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS) process...
  10. ncbi Evaluation of extractants for estimation of the phytoavailable trace metals in soils
    Neal W Menzies
    School of Land and Food Sciences, The University of Queensland, St Lucia, QLD 4072, Australia
    Environ Pollut 145:121-30. 2007
    ..01 M CaCl(2) and 0.1 M NaNO(3)) provide the most useful indication of metal phytoavailability across a range of metals of interest, although further research is required...
  11. ncbi Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
    Philip N Patsalos
    Institute of Neurology The National Hospital for Neurology and Neurosurgery, London and The Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom
    Epilepsia 49:1239-76. 2008
    ..g., in pregnancy, or when an interacting drug is added or removed); (6) to guide dose adjustments for AEDs with dose-dependent pharmacokinetics, particularly phenytoin...
  12. ncbi Polyphenols, dietary sources and bioavailability
    Massimo D'Archivio
    Centro Nazionale per la Qualita degli Alimenti e per i Rischi Alimentari, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann Ist Super Sanita 43:348-61. 2007
    ....
  13. pmc Enhancing the bioavailability of resveratrol by combining it with piperine
    Jeremy J Johnson
    Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA
    Mol Nutr Food Res 55:1169-76. 2011
    ..In this study, we examined the hypothesis that piperine will enhance the pharmacokinetic parameters of resveratrol via inhibiting its glucuronidation, thereby slowing its elimination...
  14. ncbi Phospholipids and lipid-based formulations in oral drug delivery
    Gert Fricker
    Phospholipid Research Center, Im Neuenheimer Feld 582, 69120, Heidelberg, Germany
    Pharm Res 27:1469-86. 2010
    ..Technological strategies to achieve these effects are highly diverse and offer various possibilities of liquid, semi-liquid and solid lipid-based formulations for drug delivery optimization...
  15. ncbi White beans provide more bioavailable iron than red beans: studies in poultry (Gallus gallus) and an in vitro digestion/Caco-2 model
    Elad Tako
    Department of Food Science, Cornell University, Ithaca, NY 14853, USA
    Int J Vitam Nutr Res 80:416-29. 2010
    ..We conclude that the in vivo results support the in vitro observations; i. e., white beans contain more bioavailable iron than red beans...
  16. ncbi Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability
    Kanchan Kohli
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 62, India
    Drug Discov Today 15:958-65. 2010
    ....
  17. ncbi Acute inhibition of iron bioavailability by zinc: studies in humans
    Manuel Olivares
    Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, Chile
    Biometals 25:657-64. 2012
    ..The possibility of a negative interaction should be considered for supplementation or fortification programs with both microminerals...
  18. ncbi Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design
    Jifu Hao
    Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, PR China
    Eur J Pharm Sci 47:497-505. 2012
    ..The C(max), MRT, AUMC(0→∞) and AUC(0→∞) values of SLN were approximately 1.6-fold, 1.9-fold, 5.0-fold and 2.6-fold greater than that of reference preparation, respectively...
  19. ncbi Antidepressant drugs and breastfeeding: a review of the literature
    Riccardo Davanzo
    Division of Neonatology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
    Breastfeed Med 6:89-98. 2011
    ....
  20. pmc Enhanced oral bioavailability of cyclosporine A by liposomes containing a bile salt
    Peipei Guan
    School of Pharmacy, Fudan University, Shanghai, People s Republic of China
    Int J Nanomedicine 6:965-74. 2011
    ..3% and 98.6%, respectively, with Sandimmun Neoral as the reference. The enhanced bioavailability of CyA was probably due to facilitated absorption by the liposomes containing SDC rather than improved release rate...
  21. ncbi Effect of crystal size on the in vitro dissolution and oral absorption of nitrendipine in rats
    Dengning Xia
    Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, No 103, Wenhua Road, Shenyang 110016, China
    Pharm Res 27:1965-76. 2010
    ..To investigate the effect of crystal size on the dissolution and oral absorption of nitrendipine, a poorly soluble drug, in rats...
  22. ncbi Genetic modification of low phytic acid 1-1 maize to enhance iron content and bioavailability
    Maneesha R Aluru
    Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa 50011, United States
    J Agric Food Chem 59:12954-62. 2011
    ..Furthermore, preliminary tests show that the high-iron lpa1-1 seeds have higher germination rates and seedling vigor when compared to those of the nontransgenic seeds, which may help improve their value to plant breeders...
  23. pmc Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice
    Liu Zhongfa
    College of Pharmacy, The Ohio State University, Room 152, Riffe Building, 500 W 12th Avenue, Columbus, OH 43210, USA
    Cancer Chemother Pharmacol 69:679-89. 2012
    ..Here, we established a practical nano-emulsion curcumin (NEC) containing up to 20% curcumin (w/w) and conducted the pharmacokinetics of curcuminoids and curcumin metabolites in mice...
  24. ncbi Design and development of nanovehicle-based delivery systems for preventive or therapeutic supplementation with flavonoids
    G Leonarduzzi
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Regione Gonzole 10, Orbassano, Turin, Italy
    Curr Med Chem 17:74-95. 2010
    ....
  25. ncbi Process optimization, characterization and evaluation in vivo of oxymatrine-phospholipid complex
    Peng Fei Yue
    Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
    Int J Pharm 387:139-46. 2010
    ..05), compared with those of oxymatrine or the physical mixture. This was mainly due to an improvement of the solubility of OMT-PLC...
  26. ncbi Enhanced bioavailability of the poorly water-soluble drug fenofibrate by using liposomes containing a bile salt
    Yaping Chen
    School of Pharmacy, Fudan University, Shanghai, China
    Int J Pharm 376:153-60. 2009
    ..Importantly, SPC/SDC liposomes exhibited a 1.57-fold increase in bioavailability relative to SPC/CL liposomes, indicating that liposomes containing bile salts may be used to enhance oral bioavailability of poorly water-soluble drugs...
  27. pmc Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers
    Visweswaran Navaratnam
    National Center for Drug Research CRD, Universiti Sains Malaysia USM, 11800 Minden, Pulau Pinang, Penang, Malaysia
    Eur J Clin Pharmacol 65:809-21. 2009
    ..This study examines the bioavailability and tolerability of a fixed (200 mg artesunate + 540 mg amodiaquine) and loose (200 mg + 612 mg) combination with a 2x2 cross-over design in 24 healthy volunteers...
  28. ncbi Formulation, characterization and pharmacokinetics of praziquantel-loaded hydrogenated castor oil solid lipid nanoparticles
    ShuYu Xie
    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, 2 Yuanmingyuan Road West, Beijing 100193, PR China
    Nanomedicine (Lond) 5:693-701. 2010
    ..The purpose of this study was to formulate praziquantel (PZQ)-loaded hydrogenated castor oil (HCO) solid lipid nanoparticles (SLN) to enhance the bioavailability and prolong the systemic circulation of the drug...
  29. ncbi The utility of cyclodextrins for enhancing oral bioavailability
    Rebecca L Carrier
    Department of Chemical Engineering, Northeastern University, 457 Snell Engineering Center, Boston, Massachusetts 02115, USA
    J Control Release 123:78-99. 2007
    ....
  30. ncbi Approaches for the development of solid and semi-solid lipid-based formulations
    V Jannin
    Gattefossé SAS, 36 chemin de Genas, BP 603, F 69804 Saint Priest Cedex, France
    Adv Drug Deliv Rev 60:734-46. 2008
    ....
  31. ncbi Preabsorptive metabolism of sodium arsenate by anaerobic microbiota of mouse cecum forms a variety of methylated and thiolated arsenicals
    Tatyana S Pinyayev
    Microbiological and Chemical Exposure Assessment Research Division, National Exposure Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Cincinnati, OH 45268, United States
    Chem Res Toxicol 24:475-7. 2011
    ..Metabolism of ingested arsenate to oxy- and thio-arsenicals before absorption across the gastrointestinal barrier could affect bioavailability, systemic distribution, and resulting toxicity...
  32. ncbi The impact of a meat- versus a vegetable-based diet on iron status in women of childbearing age with small iron stores
    Inge Tetens
    Dept of Human Nutrition, Faculty of Life Science, University of Copenhagen, Copenhagen, Denmark
    Eur J Nutr 46:439-45. 2007
    ..Single-meal and short-term studies have shown an enhancing effect of meat on iron absorption, but there are few interventions of longer duration comprising measurements of biomarkers of iron status...
  33. pmc Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocynin
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri, M743 Medical Sciences Building, Columbia, MO 65212, USA
    Phytomedicine 15:496-503. 2008
    ..No diapocynin was detected in any samples. These results indicate rapid glycosylation of apocynin and its transport to blood and other organs but no apparent conversion to diapocynin in vivo...
  34. pmc Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship
    Camille E Powe
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Bone Miner Res 26:1609-16. 2011
    ..These findings have important implications for vitamin D supplementation in vitamin D-deficient states. Future studies should continue to explore the relationship between free and bioavailable 25(OH)D and health outcomes...
  35. ncbi Enhanced oral bioavailability of puerarin using microemulsion vehicle
    Hongfei Wu
    Department of Pharmaceutics, Anhui University of Traditional Chinese Medicine, Anhui Province Key Laboratory of R and D of Chinese Medicine, Hefei, P R China
    Drug Dev Ind Pharm 35:138-44. 2009
    ..Puerarin microemulsion also showed good stability. These studies showed that microemulsion system of puerarin might be promising vehicles for the peroral delivery of puerarin...
  36. ncbi Bioavailability of iron, zinc, and other trace minerals from vegetarian diets
    Janet R Hunt
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    Am J Clin Nutr 78:633S-639S. 2003
    ....
  37. pmc Pharmacokinetics and enhanced oral bioavailability in beagle dogs of cyclosporine A encapsulated in glyceryl monooleate/poloxamer 407 cubic nanoparticles
    Jie Lai
    School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, China
    Int J Nanomedicine 5:13-23. 2010
    ..The enhanced bioavailability of CyA is likely due to facilitated absorption by cubic nanoparticles rather than improved release...
  38. ncbi Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system
    Wei Wu
    School of Pharmacy, Fudan University, Shanghai, China
    Eur J Pharm Biopharm 63:288-94. 2006
    ..Alternative mechanisms, such as improved lymphatic transport pathway, other than improved release may contribute to enhancement of bioavailability of silymarin...
  39. ncbi An in vitro digestion/Caco-2 cell culture system accurately predicts the effects of ascorbic acid and polyphenolic compounds on iron bioavailability in humans
    Shumei Yun
    Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca, NY 14853, USA
    J Nutr 134:2717-21. 2004
    ..If future work reproduces the precision and accuracy shown in this paper for predicting iron bioavailability to humans, then the implications for saving time and resources in iron bioavailability measurements are considerable...
  40. pmc Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults
    Rachael M Biancuzzo
    Department of Medicine, Boston University School of Medicine, MA, USA
    Am J Clin Nutr 91:1621-6. 2010
    ..Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements...
  41. ncbi Iron bioavailability from maize and beans: a comparison of human measurements with Caco-2 cell and algorithm predictions
    Jeannemarie M Beiseigel
    US Department of Agriculture Agricultural Research Service Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    Am J Clin Nutr 86:388-96. 2007
    ..An in vitro digestion and Caco-2 cell model may predict iron bioavailability to humans; however, direct comparisons are lacking...
  42. ncbi Predicting the impact of physiological and biochemical processes on oral drug bioavailability
    B Agoram
    Simulations Plus, Inc. 1220 W. Avenue J, Lancaster, CA 93534-2902, USA
    Adv Drug Deliv Rev 50:S41-67. 2001
    ..time profiles for common drugs and compare those estimates to literature data. We illustrate the simulated impact of physiological and biochemical processes on oral drug bioavailability...
  43. ncbi Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment
    T R Kommuru
    School of Pharmacy, University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209, USA
    Int J Pharm 212:233-46. 2001
    ..SEDDS have improved the bioavailability of CoQ10 significantly. The data suggest the potential use of SEDDS to provide an efficient way of improving oral absorption of lipophilic drugs...
  44. ncbi Lipid--an emerging platform for oral delivery of drugs with poor bioavailability
    Subhashis Chakraborty
    Department of Pharmaceutics, Banaras Hindu University, Varanasi, India
    Eur J Pharm Biopharm 73:1-15. 2009
    ....
  45. ncbi Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption
    Thomas Walle
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Mol Pharm 4:826-32. 2007
    ..Thus, methylation appears to be a simple and effective way of increasing both metabolic resistance and transport of the flavonoids and, most important, some of their major biological activities...
  46. ncbi Development and bioavailability assessment of ramipril nanoemulsion formulation
    Sheikh Shafiq
    Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, India
    Eur J Pharm Biopharm 66:227-43. 2007
    ..49%. The present study revealed that ramipril nanoemulsion could be used as a liquid formulation for pediatric and geriatric patients and can be formulated as self-nanoemulsifying drug delivery system (SNEDDS) as a unit dosage form...
  47. ncbi Nonheme-iron absorption, fecal ferritin excretion, and blood indexes of iron status in women consuming controlled lactoovovegetarian diets for 8 wk
    J R Hunt
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, ND 58202 9034, USA
    Am J Clin Nutr 69:944-52. 1999
    ..The characteristics of vegetarian diets suggest that these diets would have lower dietary iron bioavailability than nonvegetarian diets, but there is no evidence of iron deficiency in vegetarians...
  48. ncbi Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?
    Silvina B Lotito
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Free Radic Biol Med 41:1727-46. 2006
    ..We conclude that the large increase in plasma total antioxidant capacity observed after the consumption of flavonoid-rich foods is not caused by the flavonoids themselves, but is likely the consequence of increased uric acid levels...
  49. ncbi Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: formulation optimization, ex vivo and in vivo characterization
    Ramesh Gannu
    National Facilities in Engineering and Technology with Industrial Collaboration NAFETIC Centre, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Andhra Pradesh, India
    Int J Pharm 388:231-41. 2010
    ..Microemulsion based transdermal therapeutic system of LCDP was developed and optimized using Box-Behnken statistical design and could provide an effective treatment in the management of hypertension...
  50. ncbi Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process
    Jeong Soo Kim
    National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon 305 764, Republic of Korea
    Int J Pharm 359:211-9. 2008
    ..Further, SAS process was a powerful methodology for improving the physicochemical properties and bioavailability of atorvastatin...
  51. ncbi Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats
    Su Lan Hsiu
    Department of Pharmacy, China Medical College, Taichung, 404 Taiwan, ROC
    Life Sci 72:227-35. 2002
    ..It is suggested that concurrent use of quercetin or quercetin-containing dietary supplement or herbs with cyclosporin or other medications whose absorption and metabolism are mediated by Pgp and/or CYP3A4 should require close monitoring...
  52. ncbi Enhanced oral bioavailability of a poorly water soluble drug PNU-91325 by supersaturatable formulations
    Ping Gao
    Worldwide Pharmaceutical Sciences, Pfizer Inc, Kalamazoo, Michigan 49007, USA
    Drug Dev Ind Pharm 30:221-9. 2004
    ....
  53. ncbi Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice
    I Erlund
    Department of Nutrition, National Public Health Institute KTL, Mannerheimintie 166 F, FIN 00300 Helsinki, Finland
    J Nutr 131:235-41. 2001
    ..We conclude that because of the relatively high concentrations of flavanones in plasma after ingestion of orange juice or grapefruit juice, considerable health effects could ensue in individuals consuming them regularly...
  54. pmc Oral bioavailability of dihydroartemisinin in Vietnamese volunteers and in patients with falciparum malaria
    T Q Binh
    Tropical Diseases Research Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam
    Br J Clin Pharmacol 51:541-6. 2001
    ..Based on our mean AUC measurements, it appears that equal doses of DHA and ARTS (mg basis) should give equivalent systemic exposure to bioactive DHA in uncomplicated falciparum malaria...
  55. ncbi Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation
    Yong Mei Yin
    College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Control Release 140:86-94. 2009
    ..These results encourage further development of docetaxel microemulsions as an oral drug delivery system...
  56. ncbi Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects
    F I Kanaze
    Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur J Clin Nutr 61:472-7. 2007
    ....
  57. ncbi Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability
    Chun Yang Zhuang
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China
    Int J Pharm 394:179-85. 2010
    ..In conclusion, the NLC formulation remarkably improved the oral bioavailability of VIN and demonstrated a promising perspective for oral delivery of poorly water-soluble drugs...
  58. ncbi Arsenicals affect base excision repair by several mechanisms
    Franziska Ebert
    Institute of Food Chemistry, University of Munster, Corrensstrasse 45, 48149 Munster, Germany
    Mutat Res 715:32-41. 2011
    ....
  59. ncbi Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules
    Sandra Peltier
    U646, Angers, F 49100 France, Universite d Angers, Angers, F 49035, Cedex1, France
    Pharm Res 23:1243-50. 2006
    ..The aim of this study was to evaluate the pharmacokinetics of paclitaxel-loaded lipid nanocapsules (LNC) in rats to assess the intrinsic effect of the dosage form on the improvement of paclitaxel oral exposure...
  60. ncbi Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
    Christopher D Reiter
    Critical Care Medicine Department of the Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 8:1383-9. 2002
    ..Decompartmentalization of hemoglobin and subsequent dioxygenation of nitric oxide may explain the vascular complications shared by acute and chronic hemolytic disorders...
  61. ncbi Carotenoid bioavailability and bioconversion
    Kyung Jin Yeum
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 22:483-504. 2002
    ....
  62. ncbi The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability
    Lauretta M S Chan
    Laboratory of Pharmacology and Chemistry, Natinal Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Eur J Pharm Sci 21:25-51. 2004
    ..This review addresses the progress to date on what is known about the role and regulation of drug efflux mechanisms in the intestine and liver...
  63. ncbi Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability
    Yifan Luo
    School of Pharmacy, Department of Pharmaceutics, Mailbox 42, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016 Liaoning, P R China
    J Control Release 114:53-9. 2006
    ..These results indicated that VIN absorption is enhanced significantly by employing SLN formulations. SLNs offer a new approach to improve the oral bioavailability of poorly soluble drugs...
  64. ncbi Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats
    Sang Chul Shin
    College of Pharmacy, Chonnam National University, Bukgu, Gwangju 500 757, Republic of Korea
    Int J Pharm 313:144-9. 2006
    ..If the results are further confirmed in the clinical trials, the tamoxifen dosage should be adjusted when tamoxifen is administered with quercetin or quercetin-containing dietary supplements in order to avoid potential drug interactions...
  65. pmc Effects of a high-fat meal on the relative oral bioavailability of piperaquine
    Ing Kye Sim
    Medicine Unit Fremantle, M510, School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia
    Antimicrob Agents Chemother 49:2407-11. 2005
    ..020). The side effects, postural blood pressure changes, electrocardiographic corrected QT interval, serum glucose, and other biochemical and hematological indices were similar in the fasting and fed states over 28 days of follow-up...
  66. pmc Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 198:602-8. 2008
    ..L-Arginine infusion improves endothelial function in moderately severe malaria. Neither the longitudinal course of endothelial dysfunction nor factors associated with recovery have been characterized in severe malaria...
  67. ncbi Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats
    Qing Fang Xu
    Department of Pharmaceutics, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, People s Republic of China
    J Ethnopharmacol 84:187-92. 2003
    ..Rg(1) could be absorbed in the digestive tract and the oral bioavailability was 18.40%. Both of the low oral bioavailability of Rb(1) and rapid reduction of Rg(1) in blood indicated that formula modification is necessary...
  68. ncbi Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products
    Bernard Van Eerdenbrugh
    Laboratory for Pharmacotechnology and Biopharmacy, K U Leuven, Gasthuisberg O and N2, Herestraat 49, box 921, 3000 Leuven, Belgium
    Int J Pharm 364:64-75. 2008
    ..Finally, literature available on further nanosuspensions solidification is discussed, focussing on the maintenance of the preservation of the rapid dissolution properties of the nanocrystals after further downstream processing...
  69. ncbi Marine lipid-based liposomes increase in vivo FA bioavailability
    Maud Cansell
    Institut des Sciences et Techniques des Aliments de Bordeaux, Nutrition et Signalisation Cellulaire, F 33405 Talence Cedex, France
    Lipids 38:551-9. 2003
    ..As a whole, this study pointed out that marine PL may constitute an attractive material for the development of liposomes as oral PUFA supplements...
  70. ncbi Microemulsions: a novel approach to enhanced drug delivery
    Sushama Talegaonkar
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India
    Recent Pat Drug Deliv Formul 2:238-57. 2008
    ..also reflects the tremendous potential of these newer drug therapeutic systems. A critical evaluation of recent patents claiming different approaches to improve the drug delivery is the focus of the current review...
  71. ncbi PTC124 targets genetic disorders caused by nonsense mutations
    Ellen M Welch
    PTC Therapeutics, 100 Corporate Court, South Plainfield, New Jersey 07080, USA
    Nature 447:87-91. 2007
    ....
  72. ncbi Pharmaceutical development and preliminary clinical testing of an oral solid dispersion formulation of docetaxel (ModraDoc001)
    J J Moes
    Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Int J Pharm 420:244-50. 2011
    ..790 ± 669 ngh/mL). The low inter-individual variability of docetaxel exposure (44%), the dosing accuracy, and the absence of ethanol and polysorbate are major advantages of ModraDoc001 15 mg capsules over docetaxel premix solution...
  73. pmc Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption
    Joseph M Custodio
    Department of Biopharmaceutical Sciences, University of California, San Francisco, San Francisco, California 94143 0446, USA
    Adv Drug Deliv Rev 60:717-33. 2008
    ..That is, high fat meals and lipidic excipients would be expected to have little effect on F for Class 1 drugs; they would increase F of Class 2 drugs, while decreasing F for Class 3 drugs...
  74. ncbi Solid self-nanoemulsifying cyclosporine A pellets prepared by fluid-bed coating: stability and bioavailability study
    Yang Lei
    School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Shanghai 201203, P R China
    J Biomed Nanotechnol 8:515-21. 2012
    ..The in vivo performance of the solid SNEDDS pellets can be further improved. The fluid-bed coating technique has considerable potential for use in the preparation of SNEDDS pellets...
  75. pmc Micronutrient bioavailability: Dietary Reference Intakes and a future perspective
    K Michael Hambidge
    Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Clin Nutr 91:1430S-1432S. 2010
    ..These factors, it is argued, are best considered separately from even a broad definition of bioavailability and have the potential to provide new insights into some micronutrient requirements...
  76. pmc Pulmonary disposition of tedizolid following administration of once-daily oral 200-milligram tedizolid phosphate in healthy adult volunteers
    Seth T Housman
    Center for Anti Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA
    Antimicrob Agents Chemother 56:2627-34. 2012
    ..0. The mean ELF penetration ratio after population analyses was 39.7. This study demonstrates that tedizolid penetrates into ELF and AM to levels approximately 40-fold and 20-fold, respectively, higher than free-drug exposures in plasma...
  77. ncbi QSAR, docking and ADMET studies of artemisinin derivatives for antimalarial activity targeting plasmepsin II, a hemoglobin-degrading enzyme from P. falciparum
    Tabish Qidwai
    Metabolic and Structural Biology Department, CSIR Central Institute of Medicinal and Aromatic Plants, Lucknow, UP, India
    Curr Pharm Des 18:6133-54. 2012
    ..The experimental results obtained agreed well with the predicted values...
  78. ncbi Studies on the effects of oral administration of nutrient mixture, quercetin and red onions on the bioavailability of epigallocatechin gallate from green tea extract
    Anup Kale
    University Department of Biochemistry, R T M University, Nagpur, M S 440033, India
    Phytother Res 24:S48-55. 2010
    ..5 +/- 566.5 ng x h/mL (E) and 2490 +/- 878.1 (E + Q), but the change in t((1/2)) elimination was not significant.In conclusion, it is possible to increase the bioavailability of EGCG by supplementing it with nutrients and quercetin...
  79. ncbi Preparation and evaluation of bicyclol microemulsions for enhanced oral bioavailability
    Jae Kuk Ryu
    Pharm R and D Institute, Hanmi Pharm Co, Ltd, Hwasung 445 913, Republic of Korea
    Drug Dev Ind Pharm 38:1313-8. 2012
    ..To date, formulation development studies to improve the in vitro dissolution profiles of bicyclol and the in vivo oral absorption characteristics have not been performed...
  80. pmc Transdermal delivery of paeonol using cubic gel and microemulsion gel
    Maofu Luo
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People s Republicof China
    Int J Nanomedicine 6:1603-10. 2011
    ..The aim of this study was to develop new systems for transdermal delivery of paeonol, in particular microemulsion gel and cubic gel formulations...
  81. ncbi Provitamin a carotenoid bioavailability:what really matters?
    Sherry A Tanumihardjo
    Department of Nutritional Sciences, University of Wisconsin Madison, WI 53706, USA
    Int J Vitam Nutr Res 80:336-50. 2010
    ..Close linkages between agriculture, nutrition, and health, are essential in the quest to eradicate hunger among the poor...
  82. ncbi Absorption of folic acid and ascorbic acid from nutrient comparable beverages
    Brett Carter
    Nutritional Sciences Program, School of Public Health and Community Medicine, Univ of Washington, Seattle, WA 98195, USA
    J Food Sci 75:H289-93. 2010
    ..This study showed that similar levels of AA and FA bioavailability can be attained through ingestion of 100% OJ and a fortified beverage...
  83. pmc Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A
    Jianping Qi
    School of Pharmacy, China Pharmaceutical University, Nanjing, People s Republic of China
    Int J Nanomedicine 6:985-91. 2011
    ..In this paper, a water-in-oil (w/o) microemulsion was investigated as a system for enhancing the oral bioavailability of Biopharmaceutic Classification System (BCS) III drugs...
  84. ncbi Oral bioavailability of moxifloxacin after Roux-en-Y gastric bypass surgery
    Julie De Smet
    Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Gent, Belgium
    J Antimicrob Chemother 67:226-9. 2012
    ..This study aims to investigate the oral bioavailability of moxifloxacin in 12 healthy volunteers who underwent gastric bypass surgery...
  85. ncbi Black pepper and its pungent principle-piperine: a review of diverse physiological effects
    K Srinivasan
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India
    Crit Rev Food Sci Nutr 47:735-48. 2007
    ..Piperine, while it is non-genotoxic, has in fact been found to possess anti-mutagenic and anti-tumor influences...
  86. ncbi A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats
    Ben J Boyd
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, 381 Royal Pde, Parkville, VIC 3052, Australia
    Int J Pharm 340:52-60. 2007
    ..The results indicate that lipids that form liquid crystalline structures in excess water, may have application as an oral sustained release delivery system, providing they are not digested rapidly on administration...
  87. ncbi Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats
    Xiuguo Li
    Yanbian University, Jilin, China
    Anticancer Res 29:1411-5. 2009
    ..The dosage regimen of etoposide in cancer therapy should take drug interaction into consideration when etoposide is administered with quercetin or dietary supplements containing quercetin...
  88. pmc Population pharmacokinetics of artesunate and amodiaquine in African children
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:200. 2009
    ..The aim of this study was to evaluate the PK properties of a newly developed and registered fixed dose combination (FDC) of artesunate and amodiaquine...
  89. ncbi Toxicity of trace metals in soil as affected by soil type and aging after contamination: using calibrated bioavailability models to set ecological soil standards
    Erik Smolders
    Division Soil and Water Management, University of Leuven, Kasteelpark Arenberg 20, 3001 Leuven, Belgium
    Environ Toxicol Chem 28:1633-42. 2009
    ..The corrections for aging and for modifying effects of soil properties in metal-salt-amended soils are shown to be the main factors by which PNEC values rise above the natural background range...
  90. ncbi Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?
    Joachim Brouwers
    Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Gasthuisberg O N 2 Herestraat 49, box 921, BE 3000 Leuven, Belgium
    J Pharm Sci 98:2549-72. 2009
    ....
  91. pmc In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
    Bao Chen
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Nanomedicine 7:199-209. 2012
    ..With the aim of improving adsorption capacity and accordingly achieving high drug loading, ordered mesoporous silica with a high surface area and narrow pore size distribution was synthesized and used in a liquisolid formulation...
  92. ncbi Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability
    Li Gan
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
    Int J Pharm 396:179-87. 2010
    ..In conclusion, self-assembled liquid crystalline nanoparticles might represent a promising vehicle for effective ocular drug delivery...
  93. ncbi Diverse approaches for the enhancement of oral drug bioavailability
    Pius Fasinu
    Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa
    Biopharm Drug Dispos 32:185-209. 2011
    ....
  94. ncbi Supersaturating drug delivery systems: fast is not necessarily good enough
    Patrick Augustijns
    Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, BE 3000 Leuven, Belgium
    J Pharm Sci 101:7-9. 2012
    ..The nature of the dissolution assay (sink versus nonsink, apparatus type, and rate and extent of supersaturation) can impact the ability to efficiently use the dissolution data in the configuration of these enabling formulations...
  95. ncbi Design of fenofibrate microemulsion for improved bioavailability
    LianDong Hu
    School of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
    Int J Pharm 420:251-5. 2011
    ..63 and 1.30-fold higher than that of the capsule. Our results indicated that the microemulsions could be used as an effective formulation for enhancing the oral bioavailability of fenofibrate...
  96. ncbi Enhanced oral bioavailability of daidzein by self-microemulsifying drug delivery system
    Qi Shen
    School of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, China
    Chem Pharm Bull (Tokyo) 58:639-43. 2010
    ..Relative bioavailability of SMEDDS was enhanced about 2.5-fold compared with that of the control group. The data suggest that the use of SMEDDS provide a potential way of daidzein administered orally...
  97. pmc Single-dose pharmacokinetics of fentanyl buccal soluble film
    Niraj Vasisht
    BioDelivery Sciences International, Inc, Raleigh, North Carolina 27607, USA
    Pain Med 11:1017-23. 2010
    ....
  98. ncbi Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin
    Jun Shik Choi
    College of Pharmacy, Chosun University, Gwangju, 501 759, Korea
    Arch Pharm Res 34:607-13. 2011
    ..Therefore, concurrent use of quercetin provides a therapeutic benefit - it increases the bioavailability of doxorubicin administered orally...
  99. ncbi An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil
    Joanna Wragg
    British Geological Survey, Nottingham, United Kingdom
    Sci Total Environ 409:4016-30. 2011
    ..However, the study recommends tighter control of pH in the stomach phase extraction to improve between-laboratory variability, more reproducible in vivo validation data and that a follow up inter-laboratory trial should be carried out...
  100. ncbi Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly(anhydride) nanoparticles
    M Agüeros
    Department of Pharmaceutics and Pharmaceutical Technology, University of Navarra, Pamplona, Spain
    J Control Release 145:2-8. 2010
    ....
  101. ncbi Impact of P-glycoprotein on clopidogrel absorption
    Dirk Taubert
    Institut fur Pharmakologie, Klinikum I für Innere Medizin, Cologne, and Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Clin Pharmacol Ther 80:486-501. 2006
    ..We tested the hypothesis that the intestinal efflux transporter P-glycoprotein (P-gp) limits the oral bioavailability of clopidogrel and that variance in the MDR1 gene encoding P-gp predicts absorption variability...

Research Grants80

  1. Albumin-Encapsulated Rare Earth Nanoprobes for Multifunctional Tissue Imaging
    Charles M Roth; Fiscal Year: 2013
    ..nanoparticles encapsulated in functionalized albumin nanoshells to establish nanoprobes with high biological availability in vivo, improved biocompatibility, and functional targeting to disease targets...
  2. PAH/Metal exposure and effects assessment in Chattanooga
    Sean Richards; Fiscal Year: 2004
    ..2) Measure the biological availability of PAHs and metals by quantifying these toxicants in tissues of small mammals...
  3. Pilot-Scale Libraries Based on Nucleoside Templates for the ML Initiative
    Robert C Reynolds; Fiscal Year: 2010
    ..By definition, natural products are inherently biased towards biological availability and activity, and libraries derived there from possess unique three-dimensional structural features and ..
  4. Aluminum bioavailability from foods
    Robert Yokel; Fiscal Year: 2004
    ..abstract_text> ..
  5. A device containing immobilized chelator to remove aluminum from TPN solutions
    Robert Yokel; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Chemoprevention of colon cancer via neonatal imprinting
    Aramandla Ramesh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Effect of digestion on the cancer chemopreventative activity of tea catechins
    Mario Ferruzzi; Fiscal Year: 2007
    ..Discovery of tea compounds which hold ultimate biological significance will enable future experimental strategies for specific tea catechin forms that positively affect cancer risk and outcomes. [unreadable] [unreadable] [unreadable]..
  8. Dietary fat modulated metabolic fate of fluoranthene
    Aramandla Ramesh; Fiscal Year: 2003
    ..abstract_text> ..
  9. Evaluating Trichophyton tonsurans Carriage and Infection
    Susan Abdel Rahman; Fiscal Year: 2006
    ..abstract_text> ..
  10. Transporter-Enzyme Interplay Evaluation via Microfluidiic HTS Cell Culture Device
    Leslie Benet; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  11. 24,25-DIHYDROXYVITAMIN D: MARKER OF SALT SENSITIVITY
    Connie Weaver; Fiscal Year: 2001
    ..Furthermore, they should provide an explanation for the paradox that blacks can build higher bone density, have a lower rate of bone turnover, and excrete less urinary calcium on the same sodium loads compared to whites. ..
  12. CALCIUM METABOLISM IN ASIAN GIRLS AND POSTMENOPAUSAL WOMEN
    Connie Weaver; Fiscal Year: 2006
    ..Optimizing calcium retention during periods of rapid growth is a key nutritional strategy to build peak bone mass and reduce lifelong risk of osteoporosis. ..
  13. FUNGAL PROTEIN/GLYCOPROTEIN EXPRESSION IN TINEA CAPITIS
    Susan Abdel Rahman; Fiscal Year: 2003
    ..abstract_text> ..
  14. ANESTHETIC RENAL METABOLISM--MECHANISMS AND CONSEQUENCES
    Evan Kharasch; Fiscal Year: 2002
    ..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
  15. ANTIRETROVIRAL THERAPIES AND SUBSTANCE ABUSE
    David Greenblatt; Fiscal Year: 2002
    ..The in vitro model, if validated, has the potential to provide clinically important information on interactions involving HIV treatments and abusable drugs, at relatively low cost and with no human drug exposure. ..
  16. ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    Leslie Benet; Fiscal Year: 2002
    ....
  17. Novel noninvasive assessment of cytochrome P450 activity
    Evan Kharasch; Fiscal Year: 2009
    ..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
  18. Zn & Maternal-Infant Brain Function in S. Ethiopia: Randomized Controlled Trials
    K Hambidge; Fiscal Year: 2009
    ....
  19. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  20. Targeting Akt/NF-kappa beta for Pancreatic Cancer Therapy
    Fazlul Sarkar; Fiscal Year: 2007
    ..These results will provide mechanistic as well as pre-clinical data in support of our hypotheses and may open new and novel avenues for the treatment of human pancreatic cancer. ..
  21. Gut to Brain Pathways for Infection-Induced Anxiety
    Mark Lyte; Fiscal Year: 2005
    ..abstract_text> ..
  22. P450 PHENOTYPE AND CHEMOTHERAPY TOXICITY IN THE ELDERLY
    ELIZABETH DEES; Fiscal Year: 2006
    ..They have assembled a carefully selected group of collaborators and advisors to assist in the research projects and Dr. Dees's career development. ..
  23. Molecular Targeting of 15-Lipoxygenase-1 in Colon Cancer
    Imad Shureiqi; Fiscal Year: 2007
    ..the feasibility of tumor selective targeting of 15-LOX-1 to inhibit tumorigenesis will pave the way for future preclinical and clinical development of therapeutic strategies based on molecularly targeting 15-LOX-1 ..
  24. Phase I Radiosensitization Study of GW572016 in Recurrent Breast Cancer
    ELIZABETH DEES; Fiscal Year: 2007
    ..This proposal pilots a novel combination therapy to treat this common and challenging clinical problem. [unreadable] [unreadable] [unreadable]..
  25. Development of 13C-retinol isotope dilution techniques
    Sherry Tanumihardjo; Fiscal Year: 2006
    ..abstract_text> ..
  26. Green Tea in Chemoprevention of Prostate Cancer
    Hasan Mukhtar; Fiscal Year: 2008
    ..This proposal may be extremely valuable pre-clinical approach against PCA in humans. ..
  27. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ....
  28. Optimizing Pain Treatment in the Preterm Infant
    John van den Anker; Fiscal Year: 2008
    ..The long-term goal of the proposed investigation is to improve the use of morphine in critically ill premature neonates. [unreadable] [unreadable]..
  29. IRON SUPPLEMENTS AND ZINC IN PREGNANCY AND LACTATION
    Janet King; Fiscal Year: 2001
    ..Results from this comprehensive, longitudinal study will provide new data on the effects of iron supplementation on zinc utilization during pregnancy and lactation. ..
  30. Mitchondria-Nuclear Crosstalk in Hypoxic Gene Induction
    ROBERT POYTON; Fiscal Year: 2009
    ..g., anemia, myocardial infarction, retinopathy, and the growth of tumors). An understanding of hypoxic signaling pathways may lead to new therapies for these diseases and may help with our understanding of human aging. ..
  31. Natural History of Prostatism: The Olmsted County Study
    JENNIFER LYNN ST SAUVER; Fiscal Year: 2010
    ....
  32. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2010
    ..abstract_text> ..
  33. Mixed Models for Finite Populations
    Edward Stanek; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  34. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  35. Phase I study of 5-aza-2?-deoxycitidine in acute lymphocytic leukemia
    Guillermo Garcia Manero; Fiscal Year: 2008
    ..In this proposal, we plan to develop a new form of low-dose chemotherapy, decitabine, for these patients. Early results indicate that this is active and safe. [unreadable] [unreadable] [unreadable]..
  36. Substrate requirements of the bile acid transporter
    JAMES POLLI; Fiscal Year: 2009
    ..This systematic and progressive approach will serve as a prototypical method to elucidate the substrate requirements of other solute carrier (SLC) proteins. ..
  37. Aromatic amino acid metabolism in the pathogenesis of kwashiorkor
    Farook Jahoor; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  39. IRON & OXYGEN BIOLOGY IN SCD, HH & BETA-THAL MICE
    Elizabeth Theil; Fiscal Year: 2002
    ..The resulting information will be used to help probe the efficiency of presently available and experimental chelators, not only in promoting iron excretion but also in the prevention of defined types of cellular damage. ..
  40. Workshop on BioIron in Thalassemia, Sickle Cell Disease and Hemochromatosis
    Elizabeth Theil; Fiscal Year: 2004
    ..Fuller understanding of iron homeostasis in Thalassemia, Sickle Cell Disease and Hemochromatosis and improved disease management strategies can be expected. ..
  41. Workshop on Biolron in Thalassemia & Sickle Cell Disease
    Elizabeth Theil; Fiscal Year: 2002
    ..abstract_text> ..
  42. MOLECULAR REGULATION OF THE HUMAN BRCA 1 GENE
    DONATO ROMAGNOLO; Fiscal Year: 2003
    ..Specific aim #3 will examine the function of BRCA-1 in cell cycle regulation at different levels of genotoxic damage induced by PAHs. ..
  43. Prevention of UV-carcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2004
    ..abstract_text> ..
  44. OXYGEN SENSING AND REGULATION OF YEAST GENES
    ROBERT POYTON; Fiscal Year: 2002
    ..some other redox-sensitive oxygen binding protein involved in OCD gene expression? Aim 3: Does oxygen affect transcript turnover rate? Aim 4: What cis promoter sites mediate the OCD expression of COX6, COX5a, and CYC1? ..
  45. Oleandrin: A Novel Skin Cancer Chemopreventive Agent
    Hasan Mukhtar; Fiscal Year: 2003
    ..Successful completion of this proposal will lay the foundation for an extended program to develop oleandrin as future promising cancer chemopreventive and/or therapeutic agent in humans. ..
  46. A sensitive triple quadrupole mass spectrometer
    Stephen Barnes; Fiscal Year: 2004
    ..It is anticipated that a commercial nanospray interface for use in nanoLC-MS analysis will be available by the fall of 2003. ..
  47. LINOLEIC ACID METABOLISM AND COLON CARCINOGENESIS
    Imad Shureiqi; Fiscal Year: 2005
    ..This work will set the stage for future animals and clinical studies of LA alternative pathway modulation as means of colon cancer chemoprevention. ..
  48. TWO X-LINKED GENES THAT REGULATE MINERAL HOMEOSTASIS
    Michael Whyte; Fiscal Year: 2002
    ....
  49. Validation of rat models for resistant epilepsy therapy
    Wolfgang Loscher; Fiscal Year: 2005
    ..Our goal is to establish standard assays that can be employed by researchers to continue the search for treatments of drug resistant epilepsy. ..
  50. FLAVONOID BIOAVAILABILITY IN HUMANS-CELLULAR STUDIES
    Thomas Walle; Fiscal Year: 2005
    ..The findings from the proposed studies should help us understand the bioavailability of the flavonoids, facilitating optimization of the chemopreventive utility of these natural or synthetic compounds. ..
  51. Cell Cycle Controlling Genes in Adult Acute Lymphoma
    Guillermo Garcia Manero; Fiscal Year: 2005
    ..abstract_text> ..
  52. NEUROENDOCRINE MEDIATION OF E. COLI 0157:H7 INFECTION
    Mark Lyte; Fiscal Year: 2003
    ..The demonstration of direct neuroendocrine-bacterial interaction as a mechanism in the pathogenesis of E. coli O157:H7 infection may yield new treatments for both the prevention and treatment of hemorrhagic colitis. ..
  53. Prevention of Photocarcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2003
    ..abstract_text> ..
  54. 9.4 Tesla Fourier Transform Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2002
    ..Overall, the FT-MS instrument will sustain the high quality of biomedical research that is a hallmark of UAB. ..
  55. Apoptotic Mechanisms of Tocotrienols in Mammary Cancer
    Paul Sylvester; Fiscal Year: 2004
    ..Although caspase-8 activation is associated with death receptor signaling, the exact receptor/ligand signaling mechanism(s) mediating tocotrienol-induced caspase-8 activation has not been determined. ..
  56. Proanthocyanidins: Novel Skin Cancer Preventive Agent
    Santosh Katiyar; Fiscal Year: 2006
    ..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
  57. Center for Nutrient-Gene Interaction in Cancer Preventi*
    Stephen Barnes; Fiscal Year: 2008
    ..In addition to the main projects, the Center will organize a competitive Pilot Project/Developmental program for the evaluation of new ideas and methods pertinent to the overall development of the Center. ..
  58. Electroporation and transcutaneous extraction of drugs
    SATHYANARAYANA MURTHY; Fiscal Year: 2006
    ..Further we also plan to correlate the time course of unbound ciprofloxacin in dermal ECF with that in synovial fluid determined by microdialysis in rat. [unreadable] [unreadable] [unreadable]..
  59. Inflammatory Biomarkers and Colorectal Cancer Risk
    Gong Yang; Fiscal Year: 2010
    ..Overall, this study will contribute significantly to the understanding of the role of inflammation in the etiology of CRC and to the development of new strategies for the assessment of CRC risk. ..
  60. DIET GLYCEMIC LOAD & METABOLISM IN OBESE PREGNANT WOMEN
    Janet King; Fiscal Year: 2009
    ..In addition, new information on how the source of maternal carbohydrate intake affects carbohydrate and lipid metabolism in pregnancy will be generated. ..
  61. Nitogen reduction and xenobiotic response
    Lauren A Trepanier; Fiscal Year: 2010
    ..The ultimate goal of these studies is to find better ways to prevent these adverse reactions. ..
  62. MECHANISMS OF SKELETAL RECONSTITUTION AFTER LACTATION
    Scott Miller; Fiscal Year: 2004
    ..abstract_text> ..
  63. AMPHIPATHIC ORAL CHELATORS AND RADIONUCLIDE CONTAMINATION
    Scott Miller; Fiscal Year: 2008
    ..Because the pharmacology and toxicology of PACA chelators, such as DTPA and EDTA, are quite well understood, the development pathway of the related TT- based chelators may proceed rapidly. ..
  64. TESTOSTERONE FOR PREVENTION OF FRACTURE IN MEN
    Anne Kenny; Fiscal Year: 2005
    ....
  65. Metabolic Consequences of HAART: CYP3A and P-gp
    David Greenblatt; Fiscal Year: 2003
    ..This multidisciplinary proposal provides a clinical and scientific basis to assess the effects of currently available as well as experimental HAART medications on human CYP3A and P-gp. ..
  66. High-Throughput Assay for the Intestinal Peptide Transporter
    Peter Swaan; Fiscal Year: 2005
    ..This will aid in our understanding of the structural features that govern peptide and drug transport via this system and will significantly support studies aiming to target this transporter. ..
  67. HAART Regimens in Substance Abusers
    David Greenblatt; Fiscal Year: 2003
    ....
  68. MDR1 and Related Proteins during HIV PI Exposure
    David Greenblatt; Fiscal Year: 2005
    ..The findings will be of importance in understanding lipid disorders related to PIs as well as the kinetics of drugs used to treat HIV and related disorders. ..
  69. Porous Silicon Particles for Oral Drug Delivery
    Peter Swaan; Fiscal Year: 2007
    ..This may allow for the delivery of multiple therapeutic macromolecules in a more controlled and targeted manner to the GI tract. [unreadable] [unreadable]..
  70. CYP3A Function in Aging AfricanAmericans
    David Greenblatt; Fiscal Year: 2006
    ..This study should provide important mechanistic information on the role of age, gender, and ethnicity as sources of variability in CYP3A-mediated drug metabolism and response. ..
  71. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 2005
    ....
  72. Isothiocyanates in the Chemoprevention of Bladder Cancer
    Yuesheng Zhang; Fiscal Year: 2007
    ..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
  73. Epithelial Transport and Function of Riboflavin
    Peter Swaan; Fiscal Year: 2003
    ..These studies will yield new and important information regarding a complex epithelial transport mechanism and provide important new insights in its structural specificity and function. ..
  74. Chemopreventive Actions of Equol Enantiomers
    Kenneth Setchell; Fiscal Year: 2007
    ..These studies are relevant to humans given the ammended health claim for soy and cancer risk-reduction currently being reviewed by the FDA. ..
  75. Vitamin E and atherosclerosis in LDLR-/-mice
    Mohsen Meydani; Fiscal Year: 2006
    ..abstract_text> ..
  76. Soy Isoflavone Metabolite Equol--Formation and Fate
    Kenneth Setchell; Fiscal Year: 2008
    ..abstract_text> ..
  77. Mechansim of tea catechin's inhibition of angiogenesis
    Mohsen Meydani; Fiscal Year: 2003
    ..abstract_text> ..
  78. GARLIC PREPARATIONS AND ANTIRETROVIRAL DRUGS
    David Greenblatt; Fiscal Year: 2004
    ..The work will provide immediately applicable clinical data on garlic interactions with antiretrovirals, as well as mechanistic data identifying the interaction process and its predictability from in vitro models. ..
  79. The Proteasome as Molecular Target of Grape Polyphenols
    QING PING DOU; Fiscal Year: 2005
    ..abstract_text> ..
  80. TEA TARGETING PROTEASOME--A ROLE IN CANCER PREVENTION
    QING DOU; Fiscal Year: 2002
    ..A Future Aim is to determine whether in vivo proteasome-inhibitory ability of tea polyphenols is related to their antitumor activity using nude mice bearing human prostate tumors. ..