oxygen consumption

Summary

Summary: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)

Top Publications

  1. ncbi Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
  2. pmc Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study
    Arnt Erik Tjønna
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Circulation 118:346-54. 2008
  3. ncbi Disruption of fusion results in mitochondrial heterogeneity and dysfunction
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 280:26185-92. 2005
  4. ncbi Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    M Y El-Mir
    Laboratoire de Bioénergétique Fondamentale et Appliquée, Universite Joseph Fourier, F 38041 Grenoble Cedex 09, France
    J Biol Chem 275:223-8. 2000
  5. pmc Oxidative stress, caloric restriction, and aging
    R S Sohal
    Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
    Science 273:59-63. 1996
  6. ncbi Reliability and validity of self-reported physical activity in the Nord-Trøndelag Health Study: HUNT 1
    Nanna Kurtze
    HUNT Research Centre, Faculty of Medicine, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    Scand J Public Health 36:52-61. 2008
  7. ncbi Climate change affects marine fishes through the oxygen limitation of thermal tolerance
    Hans O Portner
    Alfred Wegener Institute for Polar and Marine Research, Animal Ecophysiology, Postfach 12 01 61, 27515 Bremerhaven, Germany
    Science 315:95-7. 2007
  8. ncbi Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis
    Satoru Kodama
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, 3 2 7 Miya machi, Mito, Ibaraki 310 0015, Japan
    JAMA 301:2024-35. 2009
  9. ncbi Caspase activation by anticancer drugs: the caspase storm
    Zhimin Tao
    Department of Chemistry, Syracuse University, 1 014 CST, Syracuse, New York 13244, USA
    Mol Pharm 4:583-95. 2007
  10. ncbi Climate change and temperature-dependent biogeography: oxygen limitation of thermal tolerance in animals
    H O Portner
    Alfred Wegener Institut fur Polar und Meeresforschung, Okophysiologie, Bremerhaven, Germany
    Naturwissenschaften 88:137-46. 2001

Research Grants

  1. Fetal Programming and Human Physical Performance
    Tom Brutsaert; Fiscal Year: 2009
  2. FUNCTIONAL ASPECTS OF OXYGEN DELIVERY
    Marcos Intaglietta; Fiscal Year: 2004
  3. NO Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2006
  4. OXIDATIVE DAMAGE AND IRON REQUIREMENTS OF THE BLASTOCYST
    COLE MANES; Fiscal Year: 1991
  5. TRANSFUSION TRIGGER EXTENSION BY PLASMA EXPANDERS
    Marcos Intaglietta; Fiscal Year: 2009
  6. ANTIMICROBIAL EFFECT OF PEROXIDASE IN LEUKOCYTES
    SEYMOUR KLEBANOFF; Fiscal Year: 1999
  7. Microxymetry Techniques for Cardiomocyte Respiration
    Govindasamy Ilangovan; Fiscal Year: 2005
  8. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2009
  9. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
  10. FEEDFORWARD CONTROL OF CORONARY BLOOD FLOW
    ERIC FEIGL; Fiscal Year: 1999

Detail Information

Publications321 found, 100 shown here

  1. ncbi Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
    ..These metabolic alterations provide a mechanistic explanation for the growth advantage and apoptotic resistance of tumor cells...
  2. pmc Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study
    Arnt Erik Tjønna
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Circulation 118:346-54. 2008
    ..We compared moderate and high exercise intensity with regard to variables associated with cardiovascular function and prognosis in patients with the metabolic syndrome...
  3. ncbi Disruption of fusion results in mitochondrial heterogeneity and dysfunction
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 280:26185-92. 2005
    ..In contrast, fragmentation of mitochondria, without severe loss of fusion, did not result in such cellular defects. Our results showed that key cellular functions decline as mitochondrial fusion is progressively abrogated...
  4. ncbi Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    M Y El-Mir
    Laboratoire de Bioénergétique Fondamentale et Appliquée, Universite Joseph Fourier, F 38041 Grenoble Cedex 09, France
    J Biol Chem 275:223-8. 2000
    ..Addition of dimethylbiguanide decreased oxygen consumption and mitochondrial membrane potential only in intact cells but not in permeabilized hepatocytes or isolated ..
  5. pmc Oxidative stress, caloric restriction, and aging
    R S Sohal
    Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
    Science 273:59-63. 1996
    ..iii) Restriction of caloric intake lowers steady-state levels of oxidative stress and damage, retards age-associated changes, and extends the maximum life-span in mammals...
  6. ncbi Reliability and validity of self-reported physical activity in the Nord-Trøndelag Health Study: HUNT 1
    Nanna Kurtze
    HUNT Research Centre, Faculty of Medicine, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    Scand J Public Health 36:52-61. 2008
    ..A third, HUNT 3, started in 2006. However, the physical activity (PA) questionnaires have not yet been validated...
  7. ncbi Climate change affects marine fishes through the oxygen limitation of thermal tolerance
    Hans O Portner
    Alfred Wegener Institute for Polar and Marine Research, Animal Ecophysiology, Postfach 12 01 61, 27515 Bremerhaven, Germany
    Science 315:95-7. 2007
    ..Decrements in aerobic performance in warming seas will thus be the first process to cause extinction or relocation to cooler waters...
  8. ncbi Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis
    Satoru Kodama
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, 3 2 7 Miya machi, Mito, Ibaraki 310 0015, Japan
    JAMA 301:2024-35. 2009
    ..Epidemiological studies have indicated an inverse association between cardiorespiratory fitness (CRF) and coronary heart disease (CHD) or all-cause mortality in healthy participants...
  9. ncbi Caspase activation by anticancer drugs: the caspase storm
    Zhimin Tao
    Department of Chemistry, Syracuse University, 1 014 CST, Syracuse, New York 13244, USA
    Mol Pharm 4:583-95. 2007
    ..Exposure of the cells to all of the drugs studied led to impaired cellular respiration and decreased cellular ATP, concomitant with caspase activation. Thus, the mitochondria are rapidly targeted by active caspases...
  10. ncbi Climate change and temperature-dependent biogeography: oxygen limitation of thermal tolerance in animals
    H O Portner
    Alfred Wegener Institut fur Polar und Meeresforschung, Okophysiologie, Bremerhaven, Germany
    Naturwissenschaften 88:137-46. 2001
    ..As a corollary, capacity limitations at a complex level of organisation, the oxygen delivery system, define thermal tolerance limits before molecular functions become disturbed...
  11. ncbi High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease
    Øivind Rognmo
    Department of Cardiology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Eur J Cardiovasc Prev Rehabil 11:216-22. 2004
    ....
  12. ncbi Comparison of methods for measuring oxygen consumption in tumor cells in vitro
    Caroline Diepart
    Laboratory of Biomedical Magnetic Resonance, Louvain Drug Research Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Anal Biochem 396:250-6. 2010
    The oxygen consumption rate of tumor cells affects tumor oxygenation and response to therapies...
  13. ncbi Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues
    Mariam Al Shamsi
    Department of Immunology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates
    Chem Res Toxicol 23:1796-805. 2010
    ..Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics...
  14. ncbi Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    Valeria R Fantin
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 9:425-34. 2006
    ..These results demonstrate that LDH-A plays a key role in tumor maintenance...
  15. pmc Estimating absolute and relative physical activity intensity across age via accelerometry in adults
    Nora E Miller
    Dept of Human Movement Sciences, University of Wisconsin Milwaukee, USA
    J Aging Phys Act 18:158-70. 2010
    ..absolute terms across age revealed substantial differences in PAI ACC count ranges. Further work is warranted to increase the applicability ofACC use relative to PAI differences associated with physiological changes with age...
  16. ncbi Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 171:972-7. 2005
    ..28 < r < 0.64, p < 0.05). Patients with chronic obstructive pulmonary disease are markedly inactive in daily life. Functional exercise capacity is the strongest correlate of physical activities in daily life...
  17. pmc Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
    Brian P Dranka
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
    Free Radic Biol Med 48:905-14. 2010
    ..64. Interestingly, the apparent respiratory control ratio (maximal mitochondrial oxygen consumption/non-ADP-linked respiration) in these cells is on the order of 23, which is substantially higher than that ..
  18. ncbi Relationship between regional myocardial oxygenation and perfusion in patients with coronary artery disease: insights from cardiovascular magnetic resonance and positron emission tomography
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom
    Circ Cardiovasc Imaging 3:32-40. 2010
    ..Thus, we sought to apply BOLD CMR at 3 T and oxygen-15-labeled water PET in patients with CAD and normal volunteers to better understand the relationship between regional myocardial oxygenation and blood flow during vasodilator stress...
  19. ncbi Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus
    N G Boulé
    School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada
    Diabetologia 46:1071-81. 2003
    ..Therefore the aim of this study was to systematically review and quantify the effects of exercise on cardiorespiratory fitness in Type 2 diabetic individuals...
  20. ncbi The energy expenditure of normal and pathologic gait
    R L Waters
    Rancho Los Amigos Medical Center, 7601 E Imperial Highway, Downey, CA 90242, USA
    Gait Posture 9:207-31. 1999
    ..This paper also will examine the effectiveness of rehabilitation interventions at mitigating the energetic penalties of disability during ambulation...
  21. ncbi Peak oxygen uptake and cardiovascular risk factors in 4631 healthy women and men
    Stian Thoresen Aspenes
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Med Sci Sports Exerc 43:1465-73. 2011
    ..Therefore, the aims of this study were to directly measure VO2peak in healthy adult men and women and to assess the association with cardiovascular risk factor levels...
  22. ncbi Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implication
    Gerhard Paul Diller
    Adult Congenital Heart Program, Department of Cardiology, Royal Brompton Hospital, London, UK
    Circulation 112:828-35. 2005
    ....
  23. ncbi p53 regulates mitochondrial respiration
    Satoaki Matoba
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 312:1650-3. 2006
    ..That SCO2 couples p53 to mitochondrial respiration provides a possible explanation for the Warburg effect and offers new clues as to how p53 might affect aging and metabolism...
  24. pmc Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro
    Yoshifumi Sato
    Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511
    J Biol Chem 286:12524-32. 2011
    Cellular oxygen consumption is a determinant of intracellular oxygen levels. Because of the high demand of mitochondrial respiration during insulin secretion, pancreatic β-cells consume large amounts of oxygen in a short time period...
  25. pmc Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenation
    Matthias Vöhringer
    Stephenson Cardiovascular MR Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada
    J Cardiovasc Magn Reson 12:20. 2010
    ....
  26. ncbi Contribution of calcium influx in mediating glucose-stimulated oxygen consumption in pancreatic islets
    Ian R Sweet
    Robert H Williams Laboratory, HSB K 165, Box 357710, University of Washington, 1959 NE Pacific St, Seattle, WA 98195 7710, USA
    Diabetes 55:3509-19. 2006
    ..of cytochrome c reduction (32-66%) in isolated rat islets, reflecting an increased production of NADH, and oxygen consumption rate (OCR) by 0.32 nmol/min/100 islets...
  27. pmc Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice
    Reyhan Westbrook
    Department of Internal Medicine, Division of Geriatric Research, Southern Illinois University School of Medicine, 801 North Rutledge Street, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 64:443-51. 2009
    ..The influence of altered GH signaling on metabolism was tested by monitoring oxygen consumption (VO(2)), respiratory quotient (RQ), and heat production in long-lived GH receptor knockout (GHRKO) and Ames ..
  28. ncbi Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain
    Amir Shmuel
    Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuron 36:1195-210. 2002
    ..The NBR was associated with reductions in blood flow and with decreases in oxygen consumption. Our findings support the contribution to the NBR of (1) a significant component of reduction in neuronal ..
  29. pmc The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    D Ricquier
    Centre de Recherche sur l Endocrinologie Moléculaire et le Développement CEREMOD, Centre National de la recherche Scientifique CNRS Unit 9078, 9 rue Jules Hetzel, 92190 Meudon, France
    Biochem J 345:161-79. 2000
    ..Other aims will be to investigate the possible roles of UCP2 and UCP3 in response to oxidative stress, lipid peroxidation, inflammatory processes, fever and regulation of temperature in certain specific parts of the body...
  30. ncbi Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation
    Erich B Tahara
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Free Radic Biol Med 46:1283-97. 2009
    ..We conducted a comprehensive and quantitative study of oxygen consumption, inner membrane potentials, and H(2)O(2) release in mitochondria isolated from rat brain, heart, kidney, ..
  31. ncbi Advances in measuring cellular bioenergetics using extracellular flux
    David A Ferrick
    Seahorse Bioscience, North Billerica, MA, USA
    Drug Discov Today 13:268-74. 2008
    ..In addition, XF is time-resolved and non-invasive, making it an attractive format for studying drug effects in vitro...
  32. ncbi Accelerated longitudinal decline of aerobic capacity in healthy older adults
    Jerome L Fleg
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Circulation 112:674-82. 2005
    ..Although peak aerobic capacity is widely recognized to decline with age, its rate of decline has been estimated primarily from cross-sectional studies that may provide misleading, overly optimistic estimates of aging changes...
  33. ncbi Performance of near-infrared spectroscopy in measuring local O(2) consumption and blood flow in skeletal muscle
    M C van Beekvelt
    Department of Physiology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands
    J Appl Physiol (1985) 90:511-9. 2001
    ....
  34. ncbi Pyruvate and oxygen consumption throughout the growth and development of murine oocytes
    Sarah E Harris
    Reproduction and Early Development Research Group, Division of Epidemiology and Biostatistics, Leeds Institute of Genetics Health and Therapeutics, School of Medicine, University of Leeds, Leeds, UK
    Mol Reprod Dev 76:231-8. 2009
    ..Carbohydrate metabolism and oxygen consumption have been analysed in a series of experiments designed to investigate important energy substrates for mouse ..
  35. ncbi Fish oil reduces heart rate and oxygen consumption during exercise
    Gregory E Peoples
    Smart Foods Centre, School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia
    J Cardiovasc Pharmacol 52:540-7. 2008
    ..This study indicates that FOs may act within the healthy heart and skeletal muscle to reduce both whole-body and myocardial O2 demand during exercise, without a decrement in performance...
  36. ncbi Effect of obesity on respiratory mechanics during rest and exercise in COPD
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    J Appl Physiol (1985) 111:10-9. 2011
    ..05) static recoil and intra-abdominal pressures than NW. Peak ventilation, oxygen consumption, and exercise endurance times were similar in OB and NW. Pulmonary resistance fell (P < 0...
  37. ncbi Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans
    Kaike K Kaisti
    Department of Anesthesiology, Turku University Hospital, Finland
    Anesthesiology 99:603-13. 2003
    ....
  38. ncbi Effect of exercise intensity, duration and mode on post-exercise oxygen consumption
    Elisabet Børsheim
    Norwegian University of Sport and Physical Education, Oslo, Norway
    Sports Med 33:1037-60. 2003
    In the recovery period after exercise there is an increase in oxygen uptake termed the 'excess post-exercise oxygen consumption' (EPOC), consisting of a rapid and a prolonged component...
  39. ncbi Metabolic equivalent: one size does not fit all
    Nuala M Byrne
    School of Human Movement Studies, Queensland Univ of Technology, Victoria Park Rd, Kelvin Grove, Q4059, Brisbane, Queensland, Australia
    J Appl Physiol (1985) 99:1112-9. 2005
    ..Using measured or predicted RMR (ml O2 x kg(-1) x min(-1) or kcal x kg(-1) x h(-1)) as a correction factor can appropriately adjust for individual differences when estimating the energy cost of moderate intensity walking (5.6 km/h)...
  40. ncbi Myocardial oxygenation in coronary artery disease: insights from blood oxygen level-dependent magnetic resonance imaging at 3 tesla
    Jayanth R Arnold
    University of Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 59:1954-64. 2012
    ..The purpose of this study was to assess the diagnostic accuracy of blood oxygen-level dependent (BOLD) MRI in suspected coronary artery disease (CAD)...
  41. ncbi Muscle oxygenation and glycolysis in females with trapezius myalgia during stress and repetitive work using microdialysis and NIRS
    Gisela Sjøgaard
    Institute of Sport Sciences and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark
    Eur J Appl Physiol 108:657-69. 2010
    ..Higher relative muscle load during PEG and STR, insufficient muscle blood flow and oxygenation may account for the higher lactate, pyruvate and pain responses among MYA versus CON...
  42. ncbi Effect of graded hypoxia on supraspinal contributions to fatigue with unilateral knee-extensor contractions
    Stuart Goodall
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    J Appl Physiol (1985) 109:1842-51. 2010
    ....
  43. pmc Frontal cerebral cortex blood flow, oxygen delivery and oxygenation during normoxic and hypoxic exercise in athletes
    Ioannis Vogiatzis
    Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, M Simou, and G P Livanos Laboratories, National and Kapodistrian University of Athens, Greece
    J Physiol 589:4027-39. 2011
    ..Thus, during maximal, but not light to moderate, exercise frontal cortex oxygen delivery is limited in hypoxia compared to normoxia. This limitation could potentially constitute the signal to limit maximal exercise capacity in hypoxia...
  44. ncbi Task-related oxygen uptake during domestic activities of daily life in patients with COPD and healthy elderly subjects
    Anouk W Vaes
    Program Development Centre, CIRO, Horn, The Netherlands
    Chest 140:970-9. 2011
    ....
  45. ncbi Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease
    R Boushel
    Sports Medicine Research Unit, Bispebjerg University Hospital, Copenhagen Muscle Research Center, Denmark
    Scand J Med Sci Sports 11:213-22. 2001
    ..These various measurements provide the opportunity to evaluate several important metabolic and circulatory patterns in very localized regions of tissue and may be fruitful in the study of occupational syndromes and a variety of diseases...
  46. ncbi Measures of exercise capacity in adults with congenital heart disease
    Roselien Buys
    Research Centre for Cardiovascular and Respiratory Rehabilitation, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101 bus 1501, 3001 Heverlee, Belgium
    Int J Cardiol 153:26-30. 2011
    Exercise capacity in grown-ups with congenital heart disease (GUCH) is mostly reported by peak oxygen consumption (peak VO(2))...
  47. ncbi Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors
    Caroline Diepart
    Biomedical Magnetic Resonance Group, Louvain Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Cancer Res 72:482-90. 2012
    ..of solid tumors by increasing tumor oxygenation [partial pressure of oxygen (pO(2))] via a decrease in oxygen consumption. Two murine models of radioresistant hypoxic cancer were used to study the effects of As(2)O(3)...
  48. ncbi Physical activity as a long-term predictor of peak oxygen uptake: the HUNT Study
    Stian Thoresen Aspenes
    K G Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Med Sci Sports Exerc 43:1675-9. 2011
    ..No population-based study has prospectively assessed the association of physical activity levels with long-term peak oxygen uptake (VO(2peak))...
  49. ncbi Near-infrared spectroscopy assessment following exercise training in patients with intermittent claudication and in untrained healthy participants
    Fabio Manfredini
    Vascular Diseases Center, University of Ferrara, Italy
    Vasc Endovascular Surg 46:315-24. 2012
    ..We measured ankle-brachial index (ABI), NIRS calf oxygen consumption at rest, NIRS dynamic muscle perfusion during an incremental test, and walking capacity...
  50. ncbi Patients with syndrome X have normal transmural myocardial perfusion and oxygenation: a 3-T cardiovascular magnetic resonance imaging study
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    Circ Cardiovasc Imaging 5:194-200. 2012
    ....
  51. pmc Effect of ischemic preconditioning in skeletal muscle measured by functional magnetic resonance imaging and spectroscopy: a randomized crossover trial
    Martin Andreas
    Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Cardiovasc Magn Reson 13:32. 2011
    ..Therefore, in-vivo NMR may enable the characterization of ischemia-reperfusion injury. The goal of this study was to evaluate whether NMR could detect the effects of ischemic preconditioning (IPC) in healthy subjects...
  52. ncbi Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice
    Sarah Hempenstall
    Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK
    Mech Ageing Dev 133:37-45. 2012
    ..Thus, we suggest that a functionally 'efficient' mitochondrial electron transport chain may be a critical mechanism underlying DR, rather than any net increase in mitochondrial content per se...
  53. ncbi Exceptional aerobic scope and cardiovascular performance of pink salmon (Oncorhynchus gorbuscha) may underlie resilience in a warming climate
    Timothy D Clark
    Department of Forest Sciences, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4
    J Exp Biol 214:3074-81. 2011
    ..Sex-specific differences existed in minimum and maximum oxygen consumption rates (M(O2,min) and M(O2,max), respectively) across the temperature range of 8 to 28°C, reflected in a ..
  54. pmc Oxygen cost of treadmill and over-ground walking in mildly disabled persons with multiple sclerosis
    Robert W Motl
    Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, 350 Freer Hall, 906 South Goodwin Ave, Urbana, IL 61801, USA
    Neurol Sci 32:255-62. 2011
    ..We provide evidence that the O(2) cost of walking is an indicator of walking dysfunction in mildly disabled persons with MS and should be considered in clinical research and practice...
  55. pmc Swimming physiology of European silver eels (Anguilla anguilla L.): energetic costs and effects on sexual maturation and reproduction
    Arjan P Palstra
    Molecular Cell Biology, Institute of Biology, Leiden University IBL, Leiden, The Netherlands
    Fish Physiol Biochem 36:297-322. 2010
    ..The induction of lipid deposition in the oocytes and the inhibition of vitellogenesis by swimming in females suggest a natural sequence of events quite different from artificial maturation protocols...
  56. ncbi Convective oxygen transport and tissue oxygen consumption in Weddell seals during aerobic dives
    R W Davis
    Department of Marine Biology, Texas A and M University at Galveston, Galveston, TX 77553, USA
    J Exp Biol 202:1091-113. 1999
    ..blood flow, convective oxygen transport (Q(O2)), muscle oxymyoglobin desaturation and regional rates of oxygen consumption (VO2)...
  57. ncbi High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colon
    Oren Tirosh
    The School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    Nutrition 23:878-86. 2007
    ..We studied the protective effects of selenium in a rat model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis to elucidate a possible mechanism of action...
  58. ncbi Effects of exercise intensity and duration on the excess post-exercise oxygen consumption
    J LaForgia
    School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA
    J Sports Sci 24:1247-64. 2006
    ..a bout of exercise is associated with an elevation in metabolism referred to as the excess post-exercise oxygen consumption (EPOC)...
  59. ncbi The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial
    Fabiana Roveda
    Heart Institute InCor, University of Sao Paulo Medical School, 44 Cerqueira cesar, Sao Paulo, SP, CEP 04503 000 Brazil
    J Am Coll Cardiol 42:854-60. 2003
    ..The goal of this study was to test the hypothesis that exercise training reduces resting sympathetic neural activation in patients with chronic advanced heart failure...
  60. pmc Concerted action of lactate oxidase and pyruvate oxidase in aerobic growth of Streptococcus pneumoniae: role of lactate as an energy source
    Hiroaki Taniai
    Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    J Bacteriol 190:3572-9. 2008
    ..As predicted by this model, exogenously added lactate was shown to increase the final growth yield in the presence of both oxidases...
  61. ncbi Aerobic and anaerobic exercise capacity in children with juvenile idiopathic arthritis
    M van Brussel
    University Hospital for Children and Youth Wilhelmina Kinderziekenhuis, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 57:891-7. 2007
    ....
  62. ncbi Relationship between exercise tolerance and muscle strength following cardiac rehabilitation: comparison of patients after cardiac surgery and patients with myocardial infarction
    Takahiro Sumide
    Juntendo Sports Clinic, Juntendo University Hospital, 3 1 3 Hongo, Bunkyo ku, Tokyo 113 8431, Japan
    J Cardiol 54:273-81. 2009
    ..The purpose of the present study was to assess the relationship between exercise tolerance and muscle strength following CR in patients after cardiac surgery and patients with MI...
  63. ncbi Impact of alterations in total hemoglobin mass on VO 2max
    Walter Schmidt
    Department of Sports Medicine Sports Physiology, University of Bayreuth, Germany
    Exerc Sport Sci Rev 38:68-75. 2010
    ..Blood doping mimics the altitude effects, however, by far exceeding its magnitude...
  64. ncbi Respiratory changes throughout ontogeny in the tobacco hornworm caterpillar, Manduca sexta
    Kendra J Greenlee
    Baylor College of Medicine, Department of Medicine, Section of Pulmonary and Critical Care Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Exp Biol 208:1385-92. 2005
    ..It seems possible that the safety margin for O2 delivery may disappear completely in the last hours before ecdysis, providing an ultimate if not proximate explanation for the necessity of molting...
  65. ncbi Exercise for the management of type 2 diabetes: a review of the evidence
    Silvano Zanuso
    Department of Exercise Science, Faculty of Medicine, University of Padua, Padua, Italy
    Acta Diabetol 47:15-22. 2010
    ....
  66. pmc Maintaining network activity in submerged hippocampal slices: importance of oxygen supply
    Norbert Hajos
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, 1083 Budapest, Hungary
    Eur J Neurosci 29:319-27. 2009
    ..These improvements to the recording conditions enable detailed studies of neurons under more realistic conditions of network activity, which are essential for a better understanding of neuronal network operation...
  67. ncbi Respiratory patterns and oxygen consumption in singing zebra finches
    Michele Franz
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Biol 206:967-78. 2003
    ..the effect of the song motor pattern on respiration using a newly developed mask system to measure oxygen consumption while simultaneously monitoring subsyringeal air sac pressure...
  68. ncbi Low doses of insulin-like growth factor-I induce mitochondrial protection in aging rats
    Juan E Puche
    Department of Medical Physiology, School of Medicine, University CEU Universidad San Pablo, Boadilla del Monte, 28668, Madrid, Spain
    Endocrinology 149:2620-7. 2008
    ..In conclusion, these results show that the cytoprotective effect of IGF-I is closely related to a mitochondrial protection, leading to reduce free radical production, oxidative damage, and apoptosis, and to increased ATP production...
  69. ncbi Effects of size and temperature on metabolic rate
    J F Gillooly
    Department of Biology, The University of New Mexico, Albuquerque, NM 87131, USA
    Science 293:2248-51. 2001
    ..Temperature and body size are primary determinants of biological time and ecological roles...
  70. ncbi The impact of oxidative stress on Arabidopsis mitochondria
    L J Sweetlove
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Plant J 32:891-904. 2002
    ....
  71. ncbi Validation of the COSMED K4 b2 portable metabolic system
    J E McLaughlin
    Department of Exercise Science and Sport Management, The University of Tennessee, Knoxville, USA
    Int J Sports Med 22:280-4. 2001
    ..During cycle ergometry on consecutive days, oxygen consumption (VO2), carbon dioxide production (VCO2), minute ventilation (VE), and respiratory exchange ratio (R) were ..
  72. pmc Modified total-body recumbent stepper exercise test for assessing peak oxygen consumption in people with chronic stroke
    Sandra A Billinger
    Metabolic, Strength, and Energy Lab, Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Phys Ther 88:1188-95. 2008
    Assessment of peak oxygen consumption (Vo(2)peak) using traditional modes of testing such as treadmill or cycle ergometer can be difficult in individuals with stroke due to balance deficits, gait impairments, or decreased coordination.
  73. ncbi Swimming for your life: locomotor effort and oxygen consumption during the green turtle (Chelonia mydas) hatchling frenzy
    David T Booth
    The University of Queensland, Physiological Ecology Group, School of Integrative Biology, QLD 4072, Australia
    J Exp Biol 212:50-5. 2009
    Swimming effort and oxygen consumption of newly emerged green turtle Chelonia mydas hatchlings was measured simultaneously and continuously for the first 18 h of swimming after hatchlings entered the water...
  74. pmc Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot study
    David J Leehey
    Veterans Affairs Hospital, Hines, IL, USA
    Cardiovasc Diabetol 8:62. 2009
    ..Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program...
  75. ncbi Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects
    Irina G Shabalina
    The Wenner Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1797:968-80. 2010
    ..conclude that there is no evidence for an involvement of UCP3 in basal, fatty-acid- or superoxide-stimulated oxygen consumption or in GDP sensitivity...
  76. pmc Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment
    Subir K Roy Chowdhury
    Division of Neurodegenerative Disorders, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada
    Diabetes 59:1082-91. 2010
    ..Impairments in mitochondrial physiology may play a role in diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in sensory neurons is due to abnormal mitochondrial respiratory function...
  77. ncbi Hemodynamic compromise as a cause of internal border-zone infarction and cortical neuronal damage in atherosclerotic middle cerebral artery disease
    Hiroshi Yamauchi
    Human Brain Research Center, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Stroke 40:3730-5. 2009
    ....
  78. pmc Low intrinsic aerobic exercise capacity and systemic insulin resistance are not associated with changes in myocardial substrate oxidation or insulin sensitivity
    Michael Schwarzer
    Department of Cardiac Surgery, University of Leipzig Heart Center, 04178 Leipzig, Germany
    Basic Res Cardiol 105:357-64. 2010
    ..in the working mode to analyze cardiac function, substrate oxidation patterns, insulin response, and oxygen consumption. After 22 generations of selective breeding, LCR displayed reduction of exercise capacity (LCR vs...
  79. ncbi The role of hypoxia, increased oxygen consumption, and hypoxia-inducible factor-1 alpha in progression of chronic kidney disease
    Tetsuhiro Tanaka
    Division for Health Service Promotion, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Curr Opin Nephrol Hypertens 19:43-50. 2010
    ..Tubulointerstitial hypoxia in the kidney has been considered a hallmark of injury and mediator of disease progression. This review focuses on hypoxia-inducible factor (HIF)-1, a master transcription factor in cellular adaptation to hypoxia...
  80. ncbi Physical fitness matters more than physical activity in controlling cardiovascular disease risk factors
    Barbara Sassen
    Department of Health and Lifestyle, University of Applied Sciences, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 16:677-83. 2009
    ..However, the role of individual components of PA, that is, intensity, duration and volume, and the inter-relationship with PF in the prevention of the MS and its individual components remains elusive...
  81. ncbi High-fat diet increases thyrotropin and oxygen consumption without altering circulating 3,5,3'-triiodothyronine (T3) and thyroxine in rats: the role of iodothyronine deiodinases, reverse T3 production, and whole-body fat oxidation
    R L Araujo
    Muscle Health Research Center, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada M3J 1P3
    Endocrinology 151:3460-9. 2010
    ..5-fold) serum rT3 in HF rats. Despite no increase in circulating levels of T(3) and T(4), whole-body oxygen consumption was increased, and substrate metabolism was shifted toward fat oxidation in HF rats...
  82. ncbi Oxygen transport characterization of a human model of progressive hemorrhage
    Kevin R Ward
    Virginia Commonwealth University Reanimation Engineering Shock Center VCURES, 1201 East Marshall Street, P O Box 980401, Richmond, VA 23298, United States
    Resuscitation 81:987-93. 2010
    ..We examined changes in oxygen transport produced by central volume redistribution in humans using lower body negative pressure (LBNP) as a potential mimetic of hemorrhage...
  83. ncbi Maximal exercise oxygen pulse as a predictor of mortality among male veterans referred for exercise testing
    Ricardo B Oliveira
    Gama Filho University, Rio de Janeiro, Brazil
    Eur J Cardiovasc Prev Rehabil 16:358-64. 2009
    ..Maximal oxygen pulse (O(2) pulse) mirrors the stroke volume response to exercise, and should therefore be a strong predictor of mortality. Limited and conflicting data are, however, available on this issue...
  84. pmc The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts
    Ying Bo Shui
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Arch Ophthalmol 127:475-82. 2009
    To investigate the rate and mechanism of oxygen consumption by the vitreous.
  85. ncbi The metabolic cost of birdsong production
    K Oberweger
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Biol 204:3379-88. 2001
    ..We measured rates of oxygen consumption during song in three songbird species, zebra finches (Taeniopygia guttata), Waterslager canaries (Serinus ..
  86. ncbi Metabolic power of European starlings Sturnus vulgaris during flight in a wind tunnel, estimated from heat transfer modelling, doubly labelled water and mask respirometry
    S Ward
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    J Exp Biol 207:4291-8. 2004
    ..Our data provide reassurance that all the techniques produce similar results and suggest that heat transfer modelling may be a useful method for estimating metabolic rate...
  87. ncbi Flattening of oxygen pulse during exercise may detect extensive myocardial ischemia
    Eva C Munhoz
    Cardiology Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    Med Sci Sports Exerc 39:1221-6. 2007
    ..In this study, we compare the oxygen pulse response to incremental treadmill exercise in patients with and without ischemia as detected by myocardial perfusion scintigraphy...
  88. ncbi Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial
    Timothy S Church
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
    JAMA 297:2081-91. 2007
    ..However, a poor understanding of the physical activity-fitness dose response relation remains...
  89. ncbi Analysis of mitochondrial function using phosphorescent oxygen-sensitive probes
    Yvonne Will
    Pfizer Drug Safety Research and Development, San Diego, USA
    Nat Protoc 1:2563-72. 2006
    ..Alterations in the rate of oxygen consumption are an informative indicator of mitochondrial dysfunction, but the use of such assays has been limited by ..
  90. ncbi Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD
    Janos Porszasz
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Rehabilitation Clinical Trials Center, Torrance, CA 90502, USA
    Chest 128:2025-34. 2005
    ..We hypothesized that endurance exercise training would reduce the degree of hyperinflation for a given level of exercise and thereby improve submaximal exercise endurance...
  91. pmc Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis
    Hani A Jouihan
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Mol Med 14:98-108. 2008
    ..These data suggest a novel mechanism of iron-induced cellular dysfunction, namely altered mitochondrial uptake of other metal ions...
  92. ncbi Peak exercise oxygen pulse and prognosis in chronic heart failure
    Carl J Lavie
    Departmentof Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Cardiol 93:588-93. 2004
    Cardiopulmonary variables, particularly peak oxygen consumption (peak VO(2)) corrected for total and lean body weight, have been confirmed to predict prognosis in patients with chronic systolic heart failure (HF)...
  93. ncbi Energy system interaction and relative contribution during maximal exercise
    P B Gastin
    Victorian Institute of Sport, Melbourne, Australia
    Sports Med 31:725-41. 2001
    ....
  94. ncbi Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart
    E A Boehm
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Am J Physiol Heart Circ Physiol 280:H977-83. 2001
    ..In conclusion, a physiological effect of UCPs on fatty acid oxidation has been found in heart at the mitochondrial and whole organ level...
  95. pmc Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure
    Sung W Choi
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 109:1179-91. 2009
    ....
  96. ncbi Overexpression of the alternative oxidase restores senescence and fertility in a long-lived respiration-deficient mutant of Podospora anserina
    S Lorin
    , 91198 Gif-sur-Yvette Cedex, France
    Mol Microbiol 42:1259-67. 2001
    ..We also suggest that expression of this oxidase in organisms naturally devoid of it could rescue respiratory defects resulting from cytochrome pathway dysfunctions...
  97. ncbi Quantitative comparison of the bolus and steady-state methods for measurement of cerebral perfusion and oxygen metabolism: positron emission tomography study using 15O-gas and water
    H Okazawa
    PET Unit, Research Institute, Shiga Medical Center, Moriyama, Japan
    J Cereb Blood Flow Metab 21:793-803. 2001
    ..Increase in CBV without a change in V0 suggested the increase might mainly be caused by venous dilatation in the ischemic regions...
  98. ncbi Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model
    R D Hoge
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Magn Reson Med 42:849-63. 1999
    The relationship between blood oxygenation level-dependent (BOLD) MRI signals, cerebral blood flow (CBF), and oxygen consumption (CMR(O2)) in the physiological steady state was investigated...
  99. ncbi Exercise testing to estimate survival in pulmonary hypertension
    Herman Groepenhoff
    Institute for Cardiovascular Research and Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Med Sci Sports Exerc 40:1725-32. 2008
    The 6-min walk distance (6MWD) predicts survival in pulmonary hypertension (PH). The peak oxygen consumption (V O2peak) measured during a cardiopulmonary exercise test (CPET) also relates to survival in PH, and it is unknown how the ..
  100. ncbi Endurance and strength training in patients with COPD
    M Jeffery Mador
    Division of Pulmonary, Critical Care and Sleep Medicine, State University of New York at Buffalo, Buffalo, NY, USA
    Chest 125:2036-45. 2004
    ..The purpose of this study was to compare the effects of endurance training only to endurance plus strength (combined) training in a randomized trial of patients with COPD...
  101. pmc Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism
    Helene Pelicano
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 69:2375-83. 2009
    ..Abrogation of CXCL14 expression using a decoy approach suppressed cell motility and invasion. Our data suggest that mitochondrial dysfunction and ROS stress promote cancer cell motility through a novel pathway mediated by CXCL14...

Research Grants19

  1. Fetal Programming and Human Physical Performance
    Tom Brutsaert; Fiscal Year: 2009
    ..Performance measures will include maximal oxygen consumption (VO2max), muscle strength, muscle fatigue rate, and the onset of blood lactate accumulation (OBLA) during ..
  2. FUNCTIONAL ASPECTS OF OXYGEN DELIVERY
    Marcos Intaglietta; Fiscal Year: 2004
    ..High oxygen consumption by the arteriolar wall/endothelium/smooth muscle causes the presence of large oxygen gradients next to the ..
  3. NO Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2006
    ..no studies that have investigated the role of increased eNOS in the control of substrate uptake and organ oxygen consumption at all...
  4. OXIDATIVE DAMAGE AND IRON REQUIREMENTS OF THE BLASTOCYST
    COLE MANES; Fiscal Year: 1991
    ..on an aspect of blastocyst metabolism that has received little attention in the past: its high level of oxygen consumption and the potential damage from reactive metabolites of oxygen...
  5. TRANSFUSION TRIGGER EXTENSION BY PLASMA EXPANDERS
    Marcos Intaglietta; Fiscal Year: 2009
    ..nitric oxide (NO) resulting in normal vascular tone and blood flow, restricting mitochondrial tissue oxygen consumption. Conversely, lowered blood viscosity and decreased heart function obtained with the presently used PEs do ..
  6. ANTIMICROBIAL EFFECT OF PEROXIDASE IN LEUKOCYTES
    SEYMOUR KLEBANOFF; Fiscal Year: 1999
    ..Phagocytes respond to perturbation of the plasma membrane with a burst of oxygen consumption and extra oxygen consumed is converted to the superoxide anion, hydrogen peroxide, hydroxyl radicals and ..
  7. Microxymetry Techniques for Cardiomocyte Respiration
    Govindasamy Ilangovan; Fiscal Year: 2005
    Measurements of oxygen consumption and generation of reactive oxygen species (ROS) in cardiomyocytes, assume importance in pathophysiology of ischemic heart disease because large quantities of oxygen free radicals are generated during ..
  8. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2009
    ..Since the NO and oxygen have high and equal affinity to the cytochrome c oxidase site in the mitochondria, oxygen consumption and respiration of cardiomyocytes, is expected to be reduced in IPC and heat stressed hearts...
  9. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
    ..Under normal conditions, the heart avoids ischemia by tightly matching myocardial oxygen consumption to coronary blood flow. To date, the mechanistic basis of this matching remains unknown...
  10. FEEDFORWARD CONTROL OF CORONARY BLOOD FLOW
    ERIC FEIGL; Fiscal Year: 1999
    ..in myocardial metabolism are secondary to adrenergic beta-receptor-mediated increases in the determinants of oxygen consumption. It is likely that beta-receptor-mediated coronary vasodilation is a significant part of the physiological ..
  11. FETAL OXYGENATION AND GROWTH DURING MATERNAL ANEMIA
    DANIEL EDELSTONE; Fiscal Year: 1990
    ..reductions in fetal O2 delivery lead to circulatory compensations that enable the fetus to maintain normal oxygen consumption and growth; (3) when such compensations are no longer sufficient for the fetus to maintain normal oxygen ..
  12. ATRIAL PEPTIDE REGULATION OF SODIUM TRANSPORT
    Mark Zeidel; Fiscal Year: 1990
    ..Recently, we have demonstrated that ANP inhibits transport-dependent oxygen consumption and sodium uptake in suspensions of IMCD cells, as well as apical sodium uptake in confluent monolayers of ..
  13. ENDOTHELIAL DYSFUNCTION AND A LOW SALT DIET
    Thomas Hintze; Fiscal Year: 2006
    ..Our recent studies suggest that the regulation of cardiac metabolism, oxygen consumption and substrate uptake, is one of the important actions of NO and that this may not only be important in the ..
  14. CORNEAL METABOLIC ACTIVITY IN HUMANS
    Joseph Bonanno; Fiscal Year: 2002
    ..In a large group of normal subjects we will measure corneal edema, oxygen consumption (Qc) and acid load produced by wearing contact lenses of high, medium and low oxygen transmissibility...
  15. INCREASED MEMBRANE POTENTIAL IN CARCINOMA MITOCHONDRIA
    JOSEPHINE MODICA NAPOLITANO; Fiscal Year: 1999
    ..potential control cell types by measuring the various parameters of oxidative phosphorylation (including oxygen consumption, electron transport, ATP synthesis, etc...
  16. SCCOR in Cardiac Dysfunction and Disease
    Daniel Kelly; Fiscal Year: 2009
    ..rates of fatty acid utilization in the diabetic heart predispose to cardiotoxic effects related to increased oxygen consumption and accumulation of intracellular lipids ("lipotoxicity")...
  17. In Vivo Measurement of Myocardial Oxygen Consumption
    BRIGITTE PONCELET; Fiscal Year: 2004
    This project focuses on developing and validating an MRI-based method to measure regional myocardial oxygen consumption (MVO2)...
  18. LabMaster: Calo/Dri-Fed/Act.XYZ/Wheel 16 Mice/Rats
    Michael Schwartz; Fiscal Year: 2009
    ..Indirect calorimetry is used to monitor rates of oxygen consumption and carbon dioxide production by monitoring gas concentrations entering and exiting the chamber and ..
  19. Pediatric Heart Network North Carolina Consortium
    Jennifer S Li; Fiscal Year: 2010
    ..Primary objective: Determine the effect of spironolactone on peak oxygen consumption. Secondary Objectives: determine efficacy of spironolactone as measured by 1) quality of life, assessed by ..