Genomes and Genes
Summary: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Publications321 found, 100 shown here
- Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cellsMin Wu
Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
Am J Physiol Cell Physiol 292:C125-36. 2007..These metabolic alterations provide a mechanistic explanation for the growth advantage and apoptotic resistance of tumor cells...
- Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot studyArnt Erik Tjønna
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
Circulation 118:346-54. 2008..We compared moderate and high exercise intensity with regard to variables associated with cardiovascular function and prognosis in patients with the metabolic syndrome...
- Disruption of fusion results in mitochondrial heterogeneity and dysfunctionHsiuchen Chen
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Biol Chem 280:26185-92. 2005..In contrast, fragmentation of mitochondria, without severe loss of fusion, did not result in such cellular defects. Our results showed that key cellular functions decline as mitochondrial fusion is progressively abrogated...
- Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex IM Y El-Mir
Laboratoire de Bioénergétique Fondamentale et Appliquée, Universite Joseph Fourier, F 38041 Grenoble Cedex 09, France
J Biol Chem 275:223-8. 2000..Addition of dimethylbiguanide decreased oxygen consumption and mitochondrial membrane potential only in intact cells but not in permeabilized hepatocytes or isolated ..
- Oxidative stress, caloric restriction, and agingR S Sohal
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
Science 273:59-63. 1996..iii) Restriction of caloric intake lowers steady-state levels of oxidative stress and damage, retards age-associated changes, and extends the maximum life-span in mammals...
- Reliability and validity of self-reported physical activity in the Nord-Trøndelag Health Study: HUNT 1Nanna Kurtze
HUNT Research Centre, Faculty of Medicine, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
Scand J Public Health 36:52-61. 2008..A third, HUNT 3, started in 2006. However, the physical activity (PA) questionnaires have not yet been validated...
- Climate change affects marine fishes through the oxygen limitation of thermal toleranceHans O Portner
Alfred Wegener Institute for Polar and Marine Research, Animal Ecophysiology, Postfach 12 01 61, 27515 Bremerhaven, Germany
Science 315:95-7. 2007..Decrements in aerobic performance in warming seas will thus be the first process to cause extinction or relocation to cooler waters...
- Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysisSatoru Kodama
Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, 3 2 7 Miya machi, Mito, Ibaraki 310 0015, Japan
JAMA 301:2024-35. 2009..Epidemiological studies have indicated an inverse association between cardiorespiratory fitness (CRF) and coronary heart disease (CHD) or all-cause mortality in healthy participants...
- Caspase activation by anticancer drugs: the caspase stormZhimin Tao
Department of Chemistry, Syracuse University, 1 014 CST, Syracuse, New York 13244, USA
Mol Pharm 4:583-95. 2007..Exposure of the cells to all of the drugs studied led to impaired cellular respiration and decreased cellular ATP, concomitant with caspase activation. Thus, the mitochondria are rapidly targeted by active caspases...
- Climate change and temperature-dependent biogeography: oxygen limitation of thermal tolerance in animalsH O Portner
Alfred Wegener Institut fur Polar und Meeresforschung, Okophysiologie, Bremerhaven, Germany
Naturwissenschaften 88:137-46. 2001..As a corollary, capacity limitations at a complex level of organisation, the oxygen delivery system, define thermal tolerance limits before molecular functions become disturbed...
- High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery diseaseØivind Rognmo
Department of Cardiology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
Eur J Cardiovasc Prev Rehabil 11:216-22. 2004....
- Comparison of methods for measuring oxygen consumption in tumor cells in vitroCaroline Diepart
Laboratory of Biomedical Magnetic Resonance, Louvain Drug Research Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
Anal Biochem 396:250-6. 2010The oxygen consumption rate of tumor cells affects tumor oxygenation and response to therapies...
- Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissuesMariam Al Shamsi
Department of Immunology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates
Chem Res Toxicol 23:1796-805. 2010..Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics...
- Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenanceValeria R Fantin
Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Cancer Cell 9:425-34. 2006..These results demonstrate that LDH-A plays a key role in tumor maintenance...
- Estimating absolute and relative physical activity intensity across age via accelerometry in adultsNora E Miller
Dept of Human Movement Sciences, University of Wisconsin Milwaukee, USA
J Aging Phys Act 18:158-70. 2010..absolute terms across age revealed substantial differences in PAI ACC count ranges. Further work is warranted to increase the applicability ofACC use relative to PAI differences associated with physiological changes with age...
- Characteristics of physical activities in daily life in chronic obstructive pulmonary diseaseFabio Pitta
Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Am J Respir Crit Care Med 171:972-7. 2005..28 < r < 0.64, p < 0.05). Patients with chronic obstructive pulmonary disease are markedly inactive in daily life. Functional exercise capacity is the strongest correlate of physical activities in daily life...
- Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen speciesBrian P Dranka
Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
Free Radic Biol Med 48:905-14. 2010..64. Interestingly, the apparent respiratory control ratio (maximal mitochondrial oxygen consumption/non-ADP-linked respiration) in these cells is on the order of 23, which is substantially higher than that ..
- Relationship between regional myocardial oxygenation and perfusion in patients with coronary artery disease: insights from cardiovascular magnetic resonance and positron emission tomographyTheodoros D Karamitsos
Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom
Circ Cardiovasc Imaging 3:32-40. 2010..Thus, we sought to apply BOLD CMR at 3 T and oxygen-15-labeled water PET in patients with CAD and normal volunteers to better understand the relationship between regional myocardial oxygenation and blood flow during vasodilator stress...
- Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitusN G Boulé
School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada
Diabetologia 46:1071-81. 2003..Therefore the aim of this study was to systematically review and quantify the effects of exercise on cardiorespiratory fitness in Type 2 diabetic individuals...
- The energy expenditure of normal and pathologic gaitR L Waters
Rancho Los Amigos Medical Center, 7601 E Imperial Highway, Downey, CA 90242, USA
Gait Posture 9:207-31. 1999..This paper also will examine the effectiveness of rehabilitation interventions at mitigating the energetic penalties of disability during ambulation...
- Peak oxygen uptake and cardiovascular risk factors in 4631 healthy women and menStian Thoresen Aspenes
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Med Sci Sports Exerc 43:1465-73. 2011..Therefore, the aims of this study were to directly measure VO2peak in healthy adult men and women and to assess the association with cardiovascular risk factor levels...
- Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implicationGerhard Paul Diller
Adult Congenital Heart Program, Department of Cardiology, Royal Brompton Hospital, London, UK
Circulation 112:828-35. 2005....
- p53 regulates mitochondrial respirationSatoaki Matoba
Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Science 312:1650-3. 2006..That SCO2 couples p53 to mitochondrial respiration provides a possible explanation for the Warburg effect and offers new clues as to how p53 might affect aging and metabolism...
- Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitroYoshifumi Sato
Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511
J Biol Chem 286:12524-32. 2011Cellular oxygen consumption is a determinant of intracellular oxygen levels. Because of the high demand of mitochondrial respiration during insulin secretion, pancreatic β-cells consume large amounts of oxygen in a short time period...
- Oxygenation-sensitive CMR for assessing vasodilator-induced changes of myocardial oxygenationMatthias Vöhringer
Stephenson Cardiovascular MR Centre at the Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada
J Cardiovasc Magn Reson 12:20. 2010....
- Contribution of calcium influx in mediating glucose-stimulated oxygen consumption in pancreatic isletsIan R Sweet
Robert H Williams Laboratory, HSB K 165, Box 357710, University of Washington, 1959 NE Pacific St, Seattle, WA 98195 7710, USA
Diabetes 55:3509-19. 2006..of cytochrome c reduction (32-66%) in isolated rat islets, reflecting an increased production of NADH, and oxygen consumption rate (OCR) by 0.32 nmol/min/100 islets...
- Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic miceReyhan Westbrook
Department of Internal Medicine, Division of Geriatric Research, Southern Illinois University School of Medicine, 801 North Rutledge Street, Springfield, IL 62794 9628, USA
J Gerontol A Biol Sci Med Sci 64:443-51. 2009..The influence of altered GH signaling on metabolism was tested by monitoring oxygen consumption (VO(2)), respiratory quotient (RQ), and heat production in long-lived GH receptor knockout (GHRKO) and Ames ..
- Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brainAmir Shmuel
Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Neuron 36:1195-210. 2002..The NBR was associated with reductions in blood flow and with decreases in oxygen consumption. Our findings support the contribution to the NBR of (1) a significant component of reduction in neuronal ..
- The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCPD Ricquier
Centre de Recherche sur l Endocrinologie Moléculaire et le Développement CEREMOD, Centre National de la recherche Scientifique CNRS Unit 9078, 9 rue Jules Hetzel, 92190 Meudon, France
Biochem J 345:161-79. 2000..Other aims will be to investigate the possible roles of UCP2 and UCP3 in response to oxidative stress, lipid peroxidation, inflammatory processes, fever and regulation of temperature in certain specific parts of the body...
- Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generationErich B Tahara
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
Free Radic Biol Med 46:1283-97. 2009..We conducted a comprehensive and quantitative study of oxygen consumption, inner membrane potentials, and H(2)O(2) release in mitochondria isolated from rat brain, heart, kidney, ..
- Advances in measuring cellular bioenergetics using extracellular fluxDavid A Ferrick
Seahorse Bioscience, North Billerica, MA, USA
Drug Discov Today 13:268-74. 2008..In addition, XF is time-resolved and non-invasive, making it an attractive format for studying drug effects in vitro...
- Accelerated longitudinal decline of aerobic capacity in healthy older adultsJerome L Fleg
Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Circulation 112:674-82. 2005..Although peak aerobic capacity is widely recognized to decline with age, its rate of decline has been estimated primarily from cross-sectional studies that may provide misleading, overly optimistic estimates of aging changes...
- Performance of near-infrared spectroscopy in measuring local O(2) consumption and blood flow in skeletal muscleM C van Beekvelt
Department of Physiology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands
J Appl Physiol (1985) 90:511-9. 2001....
- Pyruvate and oxygen consumption throughout the growth and development of murine oocytesSarah E Harris
Reproduction and Early Development Research Group, Division of Epidemiology and Biostatistics, Leeds Institute of Genetics Health and Therapeutics, School of Medicine, University of Leeds, Leeds, UK
Mol Reprod Dev 76:231-8. 2009..Carbohydrate metabolism and oxygen consumption have been analysed in a series of experiments designed to investigate important energy substrates for mouse ..
- Fish oil reduces heart rate and oxygen consumption during exerciseGregory E Peoples
Smart Foods Centre, School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia
J Cardiovasc Pharmacol 52:540-7. 2008..This study indicates that FOs may act within the healthy heart and skeletal muscle to reduce both whole-body and myocardial O2 demand during exercise, without a decrement in performance...
- Effect of obesity on respiratory mechanics during rest and exercise in COPDJosuel Ora
Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
J Appl Physiol (1985) 111:10-9. 2011..05) static recoil and intra-abdominal pressures than NW. Peak ventilation, oxygen consumption, and exercise endurance times were similar in OB and NW. Pulmonary resistance fell (P < 0...
- Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humansKaike K Kaisti
Department of Anesthesiology, Turku University Hospital, Finland
Anesthesiology 99:603-13. 2003....
- Effect of exercise intensity, duration and mode on post-exercise oxygen consumptionElisabet Børsheim
Norwegian University of Sport and Physical Education, Oslo, Norway
Sports Med 33:1037-60. 2003In the recovery period after exercise there is an increase in oxygen uptake termed the 'excess post-exercise oxygen consumption' (EPOC), consisting of a rapid and a prolonged component...
- Metabolic equivalent: one size does not fit allNuala M Byrne
School of Human Movement Studies, Queensland Univ of Technology, Victoria Park Rd, Kelvin Grove, Q4059, Brisbane, Queensland, Australia
J Appl Physiol (1985) 99:1112-9. 2005..Using measured or predicted RMR (ml O2 x kg(-1) x min(-1) or kcal x kg(-1) x h(-1)) as a correction factor can appropriately adjust for individual differences when estimating the energy cost of moderate intensity walking (5.6 km/h)...
- Myocardial oxygenation in coronary artery disease: insights from blood oxygen level-dependent magnetic resonance imaging at 3 teslaJayanth R Arnold
University of Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom
J Am Coll Cardiol 59:1954-64. 2012..The purpose of this study was to assess the diagnostic accuracy of blood oxygen-level dependent (BOLD) MRI in suspected coronary artery disease (CAD)...
- Muscle oxygenation and glycolysis in females with trapezius myalgia during stress and repetitive work using microdialysis and NIRSGisela Sjøgaard
Institute of Sport Sciences and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark
Eur J Appl Physiol 108:657-69. 2010..Higher relative muscle load during PEG and STR, insufficient muscle blood flow and oxygenation may account for the higher lactate, pyruvate and pain responses among MYA versus CON...
- Effect of graded hypoxia on supraspinal contributions to fatigue with unilateral knee-extensor contractionsStuart Goodall
Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
J Appl Physiol (1985) 109:1842-51. 2010....
- Frontal cerebral cortex blood flow, oxygen delivery and oxygenation during normoxic and hypoxic exercise in athletesIoannis Vogiatzis
Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, M Simou, and G P Livanos Laboratories, National and Kapodistrian University of Athens, Greece
J Physiol 589:4027-39. 2011..Thus, during maximal, but not light to moderate, exercise frontal cortex oxygen delivery is limited in hypoxia compared to normoxia. This limitation could potentially constitute the signal to limit maximal exercise capacity in hypoxia...
- Task-related oxygen uptake during domestic activities of daily life in patients with COPD and healthy elderly subjectsAnouk W Vaes
Program Development Centre, CIRO, Horn, The Netherlands
Chest 140:970-9. 2011....
- Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and diseaseR Boushel
Sports Medicine Research Unit, Bispebjerg University Hospital, Copenhagen Muscle Research Center, Denmark
Scand J Med Sci Sports 11:213-22. 2001..These various measurements provide the opportunity to evaluate several important metabolic and circulatory patterns in very localized regions of tissue and may be fruitful in the study of occupational syndromes and a variety of diseases...
- Measures of exercise capacity in adults with congenital heart diseaseRoselien Buys
Research Centre for Cardiovascular and Respiratory Rehabilitation, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101 bus 1501, 3001 Heverlee, Belgium
Int J Cardiol 153:26-30. 2011Exercise capacity in grown-ups with congenital heart disease (GUCH) is mostly reported by peak oxygen consumption (peak VO(2))...
- Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumorsCaroline Diepart
Biomedical Magnetic Resonance Group, Louvain Research Institute, Universite Catholique de Louvain, Brussels, Belgium
Cancer Res 72:482-90. 2012..of solid tumors by increasing tumor oxygenation [partial pressure of oxygen (pO(2))] via a decrease in oxygen consumption. Two murine models of radioresistant hypoxic cancer were used to study the effects of As(2)O(3)...
- Physical activity as a long-term predictor of peak oxygen uptake: the HUNT StudyStian Thoresen Aspenes
K G Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Med Sci Sports Exerc 43:1675-9. 2011..No population-based study has prospectively assessed the association of physical activity levels with long-term peak oxygen uptake (VO(2peak))...
- Near-infrared spectroscopy assessment following exercise training in patients with intermittent claudication and in untrained healthy participantsFabio Manfredini
Vascular Diseases Center, University of Ferrara, Italy
Vasc Endovascular Surg 46:315-24. 2012..We measured ankle-brachial index (ABI), NIRS calf oxygen consumption at rest, NIRS dynamic muscle perfusion during an incremental test, and walking capacity...
- Patients with syndrome X have normal transmural myocardial perfusion and oxygenation: a 3-T cardiovascular magnetic resonance imaging studyTheodoros D Karamitsos
Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
Circ Cardiovasc Imaging 5:194-200. 2012....
- Effect of ischemic preconditioning in skeletal muscle measured by functional magnetic resonance imaging and spectroscopy: a randomized crossover trialMartin Andreas
Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Cardiovasc Magn Reson 13:32. 2011..Therefore, in-vivo NMR may enable the characterization of ischemia-reperfusion injury. The goal of this study was to evaluate whether NMR could detect the effects of ischemic preconditioning (IPC) in healthy subjects...
- Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 miceSarah Hempenstall
Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK
Mech Ageing Dev 133:37-45. 2012..Thus, we suggest that a functionally 'efficient' mitochondrial electron transport chain may be a critical mechanism underlying DR, rather than any net increase in mitochondrial content per se...
- Exceptional aerobic scope and cardiovascular performance of pink salmon (Oncorhynchus gorbuscha) may underlie resilience in a warming climateTimothy D Clark
Department of Forest Sciences, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4
J Exp Biol 214:3074-81. 2011..Sex-specific differences existed in minimum and maximum oxygen consumption rates (M(O2,min) and M(O2,max), respectively) across the temperature range of 8 to 28°C, reflected in a ..
- Oxygen cost of treadmill and over-ground walking in mildly disabled persons with multiple sclerosisRobert W Motl
Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, 350 Freer Hall, 906 South Goodwin Ave, Urbana, IL 61801, USA
Neurol Sci 32:255-62. 2011..We provide evidence that the O(2) cost of walking is an indicator of walking dysfunction in mildly disabled persons with MS and should be considered in clinical research and practice...
- Swimming physiology of European silver eels (Anguilla anguilla L.): energetic costs and effects on sexual maturation and reproductionArjan P Palstra
Molecular Cell Biology, Institute of Biology, Leiden University IBL, Leiden, The Netherlands
Fish Physiol Biochem 36:297-322. 2010..The induction of lipid deposition in the oocytes and the inhibition of vitellogenesis by swimming in females suggest a natural sequence of events quite different from artificial maturation protocols...
- Convective oxygen transport and tissue oxygen consumption in Weddell seals during aerobic divesR W Davis
Department of Marine Biology, Texas A and M University at Galveston, Galveston, TX 77553, USA
J Exp Biol 202:1091-113. 1999..blood flow, convective oxygen transport (Q(O2)), muscle oxymyoglobin desaturation and regional rates of oxygen consumption (VO2)...
- High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colonOren Tirosh
The School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Nutrition 23:878-86. 2007..We studied the protective effects of selenium in a rat model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis to elucidate a possible mechanism of action...
- Effects of exercise intensity and duration on the excess post-exercise oxygen consumptionJ LaForgia
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA
J Sports Sci 24:1247-64. 2006..a bout of exercise is associated with an elevation in metabolism referred to as the excess post-exercise oxygen consumption (EPOC)...
- The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trialFabiana Roveda
Heart Institute InCor, University of Sao Paulo Medical School, 44 Cerqueira cesar, Sao Paulo, SP, CEP 04503 000 Brazil
J Am Coll Cardiol 42:854-60. 2003..The goal of this study was to test the hypothesis that exercise training reduces resting sympathetic neural activation in patients with chronic advanced heart failure...
- Concerted action of lactate oxidase and pyruvate oxidase in aerobic growth of Streptococcus pneumoniae: role of lactate as an energy sourceHiroaki Taniai
Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
J Bacteriol 190:3572-9. 2008..As predicted by this model, exogenously added lactate was shown to increase the final growth yield in the presence of both oxidases...
- Aerobic and anaerobic exercise capacity in children with juvenile idiopathic arthritisM van Brussel
University Hospital for Children and Youth Wilhelmina Kinderziekenhuis, University Medical Center Utrecht, Utrecht, The Netherlands
Arthritis Rheum 57:891-7. 2007....
- Relationship between exercise tolerance and muscle strength following cardiac rehabilitation: comparison of patients after cardiac surgery and patients with myocardial infarctionTakahiro Sumide
Juntendo Sports Clinic, Juntendo University Hospital, 3 1 3 Hongo, Bunkyo ku, Tokyo 113 8431, Japan
J Cardiol 54:273-81. 2009..The purpose of the present study was to assess the relationship between exercise tolerance and muscle strength following CR in patients after cardiac surgery and patients with MI...
- Impact of alterations in total hemoglobin mass on VO 2maxWalter Schmidt
Department of Sports Medicine Sports Physiology, University of Bayreuth, Germany
Exerc Sport Sci Rev 38:68-75. 2010..Blood doping mimics the altitude effects, however, by far exceeding its magnitude...
- Respiratory changes throughout ontogeny in the tobacco hornworm caterpillar, Manduca sextaKendra J Greenlee
Baylor College of Medicine, Department of Medicine, Section of Pulmonary and Critical Care Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Exp Biol 208:1385-92. 2005..It seems possible that the safety margin for O2 delivery may disappear completely in the last hours before ecdysis, providing an ultimate if not proximate explanation for the necessity of molting...
- Exercise for the management of type 2 diabetes: a review of the evidenceSilvano Zanuso
Department of Exercise Science, Faculty of Medicine, University of Padua, Padua, Italy
Acta Diabetol 47:15-22. 2010....
- Maintaining network activity in submerged hippocampal slices: importance of oxygen supplyNorbert Hajos
Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, 1083 Budapest, Hungary
Eur J Neurosci 29:319-27. 2009..These improvements to the recording conditions enable detailed studies of neurons under more realistic conditions of network activity, which are essential for a better understanding of neuronal network operation...
- Respiratory patterns and oxygen consumption in singing zebra finchesMichele Franz
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
J Exp Biol 206:967-78. 2003..the effect of the song motor pattern on respiration using a newly developed mask system to measure oxygen consumption while simultaneously monitoring subsyringeal air sac pressure...
- Low doses of insulin-like growth factor-I induce mitochondrial protection in aging ratsJuan E Puche
Department of Medical Physiology, School of Medicine, University CEU Universidad San Pablo, Boadilla del Monte, 28668, Madrid, Spain
Endocrinology 149:2620-7. 2008..In conclusion, these results show that the cytoprotective effect of IGF-I is closely related to a mitochondrial protection, leading to reduce free radical production, oxidative damage, and apoptosis, and to increased ATP production...
- Effects of size and temperature on metabolic rateJ F Gillooly
Department of Biology, The University of New Mexico, Albuquerque, NM 87131, USA
Science 293:2248-51. 2001..Temperature and body size are primary determinants of biological time and ecological roles...
- The impact of oxidative stress on Arabidopsis mitochondriaL J Sweetlove
Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
Plant J 32:891-904. 2002....
- Validation of the COSMED K4 b2 portable metabolic systemJ E McLaughlin
Department of Exercise Science and Sport Management, The University of Tennessee, Knoxville, USA
Int J Sports Med 22:280-4. 2001..During cycle ergometry on consecutive days, oxygen consumption (VO2), carbon dioxide production (VCO2), minute ventilation (VE), and respiratory exchange ratio (R) were ..
- Modified total-body recumbent stepper exercise test for assessing peak oxygen consumption in people with chronic strokeSandra A Billinger
Metabolic, Strength, and Energy Lab, Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Phys Ther 88:1188-95. 2008Assessment of peak oxygen consumption (Vo(2)peak) using traditional modes of testing such as treadmill or cycle ergometer can be difficult in individuals with stroke due to balance deficits, gait impairments, or decreased coordination.
- Swimming for your life: locomotor effort and oxygen consumption during the green turtle (Chelonia mydas) hatchling frenzyDavid T Booth
The University of Queensland, Physiological Ecology Group, School of Integrative Biology, QLD 4072, Australia
J Exp Biol 212:50-5. 2009Swimming effort and oxygen consumption of newly emerged green turtle Chelonia mydas hatchlings was measured simultaneously and continuously for the first 18 h of swimming after hatchlings entered the water...
- Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot studyDavid J Leehey
Veterans Affairs Hospital, Hines, IL, USA
Cardiovasc Diabetol 8:62. 2009..Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program...
- Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effectsIrina G Shabalina
The Wenner Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
Biochim Biophys Acta 1797:968-80. 2010..conclude that there is no evidence for an involvement of UCP3 in basal, fatty-acid- or superoxide-stimulated oxygen consumption or in GDP sensitivity...
- Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatmentSubir K Roy Chowdhury
Division of Neurodegenerative Disorders, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada
Diabetes 59:1082-91. 2010..Impairments in mitochondrial physiology may play a role in diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in sensory neurons is due to abnormal mitochondrial respiratory function...
- Hemodynamic compromise as a cause of internal border-zone infarction and cortical neuronal damage in atherosclerotic middle cerebral artery diseaseHiroshi Yamauchi
Human Brain Research Center, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
Stroke 40:3730-5. 2009....
- Low intrinsic aerobic exercise capacity and systemic insulin resistance are not associated with changes in myocardial substrate oxidation or insulin sensitivityMichael Schwarzer
Department of Cardiac Surgery, University of Leipzig Heart Center, 04178 Leipzig, Germany
Basic Res Cardiol 105:357-64. 2010..in the working mode to analyze cardiac function, substrate oxidation patterns, insulin response, and oxygen consumption. After 22 generations of selective breeding, LCR displayed reduction of exercise capacity (LCR vs...
- The role of hypoxia, increased oxygen consumption, and hypoxia-inducible factor-1 alpha in progression of chronic kidney diseaseTetsuhiro Tanaka
Division for Health Service Promotion, University of Tokyo, Bunkyo ku, Tokyo, Japan
Curr Opin Nephrol Hypertens 19:43-50. 2010..Tubulointerstitial hypoxia in the kidney has been considered a hallmark of injury and mediator of disease progression. This review focuses on hypoxia-inducible factor (HIF)-1, a master transcription factor in cellular adaptation to hypoxia...
- Physical fitness matters more than physical activity in controlling cardiovascular disease risk factorsBarbara Sassen
Department of Health and Lifestyle, University of Applied Sciences, Utrecht, The Netherlands
Eur J Cardiovasc Prev Rehabil 16:677-83. 2009..However, the role of individual components of PA, that is, intensity, duration and volume, and the inter-relationship with PF in the prevention of the MS and its individual components remains elusive...
- High-fat diet increases thyrotropin and oxygen consumption without altering circulating 3,5,3'-triiodothyronine (T3) and thyroxine in rats: the role of iodothyronine deiodinases, reverse T3 production, and whole-body fat oxidationR L Araujo
Muscle Health Research Center, School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada M3J 1P3
Endocrinology 151:3460-9. 2010..5-fold) serum rT3 in HF rats. Despite no increase in circulating levels of T(3) and T(4), whole-body oxygen consumption was increased, and substrate metabolism was shifted toward fat oxidation in HF rats...
- Oxygen transport characterization of a human model of progressive hemorrhageKevin R Ward
Virginia Commonwealth University Reanimation Engineering Shock Center VCURES, 1201 East Marshall Street, P O Box 980401, Richmond, VA 23298, United States
Resuscitation 81:987-93. 2010..We examined changes in oxygen transport produced by central volume redistribution in humans using lower body negative pressure (LBNP) as a potential mimetic of hemorrhage...
- Maximal exercise oxygen pulse as a predictor of mortality among male veterans referred for exercise testingRicardo B Oliveira
Gama Filho University, Rio de Janeiro, Brazil
Eur J Cardiovasc Prev Rehabil 16:358-64. 2009..Maximal oxygen pulse (O(2) pulse) mirrors the stroke volume response to exercise, and should therefore be a strong predictor of mortality. Limited and conflicting data are, however, available on this issue...
- The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataractsYing Bo Shui
Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
Arch Ophthalmol 127:475-82. 2009To investigate the rate and mechanism of oxygen consumption by the vitreous.
- The metabolic cost of birdsong productionK Oberweger
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
J Exp Biol 204:3379-88. 2001..We measured rates of oxygen consumption during song in three songbird species, zebra finches (Taeniopygia guttata), Waterslager canaries (Serinus ..
- Metabolic power of European starlings Sturnus vulgaris during flight in a wind tunnel, estimated from heat transfer modelling, doubly labelled water and mask respirometryS Ward
Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
J Exp Biol 207:4291-8. 2004..Our data provide reassurance that all the techniques produce similar results and suggest that heat transfer modelling may be a useful method for estimating metabolic rate...
- Flattening of oxygen pulse during exercise may detect extensive myocardial ischemiaEva C Munhoz
Cardiology Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
Med Sci Sports Exerc 39:1221-6. 2007..In this study, we compare the oxygen pulse response to incremental treadmill exercise in patients with and without ischemia as detected by myocardial perfusion scintigraphy...
- Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trialTimothy S Church
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
JAMA 297:2081-91. 2007..However, a poor understanding of the physical activity-fitness dose response relation remains...
- Analysis of mitochondrial function using phosphorescent oxygen-sensitive probesYvonne Will
Pfizer Drug Safety Research and Development, San Diego, USA
Nat Protoc 1:2563-72. 2006..Alterations in the rate of oxygen consumption are an informative indicator of mitochondrial dysfunction, but the use of such assays has been limited by ..
- Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPDJanos Porszasz
Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Rehabilitation Clinical Trials Center, Torrance, CA 90502, USA
Chest 128:2025-34. 2005..We hypothesized that endurance exercise training would reduce the degree of hyperinflation for a given level of exercise and thereby improve submaximal exercise endurance...
- Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosisHani A Jouihan
Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
Mol Med 14:98-108. 2008..These data suggest a novel mechanism of iron-induced cellular dysfunction, namely altered mitochondrial uptake of other metal ions...
- Peak exercise oxygen pulse and prognosis in chronic heart failureCarl J Lavie
Departmentof Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
Am J Cardiol 93:588-93. 2004Cardiopulmonary variables, particularly peak oxygen consumption (peak VO(2)) corrected for total and lean body weight, have been confirmed to predict prognosis in patients with chronic systolic heart failure (HF)...
- Energy system interaction and relative contribution during maximal exerciseP B Gastin
Victorian Institute of Sport, Melbourne, Australia
Sports Med 31:725-41. 2001....
- Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heartE A Boehm
Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
Am J Physiol Heart Circ Physiol 280:H977-83. 2001..In conclusion, a physiological effect of UCPs on fatty acid oxidation has been found in heart at the mitochondrial and whole organ level...
- Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failureSung W Choi
Buck Institute for Age Research, Novato, California 94945, USA
J Neurochem 109:1179-91. 2009....
- Overexpression of the alternative oxidase restores senescence and fertility in a long-lived respiration-deficient mutant of Podospora anserinaS Lorin
, 91198 Gif-sur-Yvette Cedex, France
Mol Microbiol 42:1259-67. 2001..We also suggest that expression of this oxidase in organisms naturally devoid of it could rescue respiratory defects resulting from cytochrome pathway dysfunctions...
- Quantitative comparison of the bolus and steady-state methods for measurement of cerebral perfusion and oxygen metabolism: positron emission tomography study using 15O-gas and waterH Okazawa
PET Unit, Research Institute, Shiga Medical Center, Moriyama, Japan
J Cereb Blood Flow Metab 21:793-803. 2001..Increase in CBV without a change in V0 suggested the increase might mainly be caused by venous dilatation in the ischemic regions...
- Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution modelR D Hoge
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Magn Reson Med 42:849-63. 1999The relationship between blood oxygenation level-dependent (BOLD) MRI signals, cerebral blood flow (CBF), and oxygen consumption (CMR(O2)) in the physiological steady state was investigated...
- Exercise testing to estimate survival in pulmonary hypertensionHerman Groepenhoff
Institute for Cardiovascular Research and Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
Med Sci Sports Exerc 40:1725-32. 2008The 6-min walk distance (6MWD) predicts survival in pulmonary hypertension (PH). The peak oxygen consumption (V O2peak) measured during a cardiopulmonary exercise test (CPET) also relates to survival in PH, and it is unknown how the ..
- Endurance and strength training in patients with COPDM Jeffery Mador
Division of Pulmonary, Critical Care and Sleep Medicine, State University of New York at Buffalo, Buffalo, NY, USA
Chest 125:2036-45. 2004..The purpose of this study was to compare the effects of endurance training only to endurance plus strength (combined) training in a randomized trial of patients with COPD...
- Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanismHelene Pelicano
Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer Res 69:2375-83. 2009..Abrogation of CXCL14 expression using a decoy approach suppressed cell motility and invasion. Our data suggest that mitochondrial dysfunction and ROS stress promote cancer cell motility through a novel pathway mediated by CXCL14...
- Fetal Programming and Human Physical PerformanceTom Brutsaert; Fiscal Year: 2009..Performance measures will include maximal oxygen consumption (VO2max), muscle strength, muscle fatigue rate, and the onset of blood lactate accumulation (OBLA) during ..
- FUNCTIONAL ASPECTS OF OXYGEN DELIVERYMarcos Intaglietta; Fiscal Year: 2004..High oxygen consumption by the arteriolar wall/endothelium/smooth muscle causes the presence of large oxygen gradients next to the ..
- NO Metabolic Control in PregnancyThomas Hintze; Fiscal Year: 2006..no studies that have investigated the role of increased eNOS in the control of substrate uptake and organ oxygen consumption at all...
- OXIDATIVE DAMAGE AND IRON REQUIREMENTS OF THE BLASTOCYSTCOLE MANES; Fiscal Year: 1991..on an aspect of blastocyst metabolism that has received little attention in the past: its high level of oxygen consumption and the potential damage from reactive metabolites of oxygen...
- TRANSFUSION TRIGGER EXTENSION BY PLASMA EXPANDERSMarcos Intaglietta; Fiscal Year: 2009..nitric oxide (NO) resulting in normal vascular tone and blood flow, restricting mitochondrial tissue oxygen consumption. Conversely, lowered blood viscosity and decreased heart function obtained with the presently used PEs do ..
- ANTIMICROBIAL EFFECT OF PEROXIDASE IN LEUKOCYTESSEYMOUR KLEBANOFF; Fiscal Year: 1999..Phagocytes respond to perturbation of the plasma membrane with a burst of oxygen consumption and extra oxygen consumed is converted to the superoxide anion, hydrogen peroxide, hydroxyl radicals and ..
- Microxymetry Techniques for Cardiomocyte RespirationGovindasamy Ilangovan; Fiscal Year: 2005Measurements of oxygen consumption and generation of reactive oxygen species (ROS) in cardiomyocytes, assume importance in pathophysiology of ischemic heart disease because large quantities of oxygen free radicals are generated during ..
- Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the HeartGovindasamy Ilangovan; Fiscal Year: 2009..Since the NO and oxygen have high and equal affinity to the cytochrome c oxidase site in the mitochondria, oxygen consumption and respiration of cardiomyocytes, is expected to be reduced in IPC and heat stressed hearts...
- Nitric Oxide and Compensatory Coronary VasodilationDavid Stepp; Fiscal Year: 2004..Under normal conditions, the heart avoids ischemia by tightly matching myocardial oxygen consumption to coronary blood flow. To date, the mechanistic basis of this matching remains unknown...
- FEEDFORWARD CONTROL OF CORONARY BLOOD FLOWERIC FEIGL; Fiscal Year: 1999..in myocardial metabolism are secondary to adrenergic beta-receptor-mediated increases in the determinants of oxygen consumption. It is likely that beta-receptor-mediated coronary vasodilation is a significant part of the physiological ..
- FETAL OXYGENATION AND GROWTH DURING MATERNAL ANEMIADANIEL EDELSTONE; Fiscal Year: 1990..reductions in fetal O2 delivery lead to circulatory compensations that enable the fetus to maintain normal oxygen consumption and growth; (3) when such compensations are no longer sufficient for the fetus to maintain normal oxygen ..
- ATRIAL PEPTIDE REGULATION OF SODIUM TRANSPORTMark Zeidel; Fiscal Year: 1990..Recently, we have demonstrated that ANP inhibits transport-dependent oxygen consumption and sodium uptake in suspensions of IMCD cells, as well as apical sodium uptake in confluent monolayers of ..
- ENDOTHELIAL DYSFUNCTION AND A LOW SALT DIETThomas Hintze; Fiscal Year: 2006..Our recent studies suggest that the regulation of cardiac metabolism, oxygen consumption and substrate uptake, is one of the important actions of NO and that this may not only be important in the ..
- CORNEAL METABOLIC ACTIVITY IN HUMANSJoseph Bonanno; Fiscal Year: 2002..In a large group of normal subjects we will measure corneal edema, oxygen consumption (Qc) and acid load produced by wearing contact lenses of high, medium and low oxygen transmissibility...
- INCREASED MEMBRANE POTENTIAL IN CARCINOMA MITOCHONDRIAJOSEPHINE MODICA NAPOLITANO; Fiscal Year: 1999..potential control cell types by measuring the various parameters of oxidative phosphorylation (including oxygen consumption, electron transport, ATP synthesis, etc...
- SCCOR in Cardiac Dysfunction and DiseaseDaniel Kelly; Fiscal Year: 2009..rates of fatty acid utilization in the diabetic heart predispose to cardiotoxic effects related to increased oxygen consumption and accumulation of intracellular lipids ("lipotoxicity")...
- In Vivo Measurement of Myocardial Oxygen ConsumptionBRIGITTE PONCELET; Fiscal Year: 2004This project focuses on developing and validating an MRI-based method to measure regional myocardial oxygen consumption (MVO2)...
- LabMaster: Calo/Dri-Fed/Act.XYZ/Wheel 16 Mice/RatsMichael Schwartz; Fiscal Year: 2009..Indirect calorimetry is used to monitor rates of oxygen consumption and carbon dioxide production by monitoring gas concentrations entering and exiting the chamber and ..
- Pediatric Heart Network North Carolina ConsortiumJennifer S Li; Fiscal Year: 2010..Primary objective: Determine the effect of spironolactone on peak oxygen consumption. Secondary Objectives: determine efficacy of spironolactone as measured by 1) quality of life, assessed by ..