oxidative stress

Summary

Summary: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

Top Publications

  1. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
  2. doi Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    Rongbin Zhou
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nat Immunol 11:136-40. 2010
  3. doi Metals, oxidative stress and neurodegenerative disorders
    Klaudia Jomova
    Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University, SK 949 74, Nitra, Slovakia
    Mol Cell Biochem 345:91-104. 2010
  4. ncbi Free radicals and antioxidants in normal physiological functions and human disease
    Marian Valko
    Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
    Int J Biochem Cell Biol 39:44-84. 2007
  5. ncbi Reactive oxygen species: metabolism, oxidative stress, and signal transduction
    Klaus Apel
    Institute of Plant Sciences, Swiss Federal Institute of Technology, Universitätstr 2, 8092 Zurich, Switzerland
    Annu Rev Plant Biol 55:373-99. 2004
  6. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  7. ncbi Oxidative stress, antioxidants and stress tolerance
    Ron Mittler
    Dept of Botany, Plant Sciences Institute, 353 Bessey Hall, Iowa State University, Ames, IA 50011, USA
    Trends Plant Sci 7:405-10. 2002
  8. ncbi An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
    Heather P Harding
    Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 11:619-33. 2003
  9. ncbi Latest advances in understanding preeclampsia
    Christopher W Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 308:1592-4. 2005
  10. pmc Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
    K D McCullough
    Cell Stress and Aging Section, Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    Mol Cell Biol 21:1249-59. 2001

Detail Information

Publications346 found, 100 shown here

  1. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
    ..Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.
  2. doi Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    Rongbin Zhou
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Nat Immunol 11:136-40. 2010
    ..The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1beta in the pathogenesis of type 2 diabetes...
  3. doi Metals, oxidative stress and neurodegenerative disorders
    Klaudia Jomova
    Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University, SK 949 74, Nitra, Slovakia
    Mol Cell Biochem 345:91-104. 2010
    ..However, it is clear, that the underlying factor in the neurological disorders is increased oxidative stress substantiated by the findings that the protein side-chains are modified either directly by reactive oxygen ..
  4. ncbi Free radicals and antioxidants in normal physiological functions and human disease
    Marian Valko
    Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
    Int J Biochem Cell Biol 39:44-84. 2007
    ..arising either from mitochondrial electron-transport chain or excessive stimulation of NAD(P)H) results in oxidative stress, a deleterious process that can be an important mediator of damage to cell structures, including lipids and ..
  5. ncbi Reactive oxygen species: metabolism, oxidative stress, and signal transduction
    Klaus Apel
    Institute of Plant Sciences, Swiss Federal Institute of Technology, Universitätstr 2, 8092 Zurich, Switzerland
    Annu Rev Plant Biol 55:373-99. 2004
    ..Considering recent ROS-induced genome-wide expression analyses, the possible functions and mechanisms for ROS sensing and signaling in plants are compared with those in animals and yeast...
  6. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  7. ncbi Oxidative stress, antioxidants and stress tolerance
    Ron Mittler
    Dept of Botany, Plant Sciences Institute, 353 Bessey Hall, Iowa State University, Ames, IA 50011, USA
    Trends Plant Sci 7:405-10. 2002
    ..These raise several intriguing questions about the relationships between ROI signaling, ROI stress and the production and scavenging of ROIs in the different cellular compartments...
  8. ncbi An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
    Heather P Harding
    Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 11:619-33. 2003
    ..are impaired in expressing genes involved in amino acid import, glutathione biosynthesis, and resistance to oxidative stress. Perk(-/-) cells, lacking an upstream ER stress-activated eIF2alpha kinase that activates Atf4, accumulate ..
  9. ncbi Latest advances in understanding preeclampsia
    Christopher W Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 308:1592-4. 2005
    ..This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings...
  10. pmc Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
    K D McCullough
    Cell Stress and Aging Section, Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    Mol Cell Biol 21:1249-59. 2001
    ..We conclude that Gadd153 sensitizes cells to ER stress through mechanisms that involve down-regulation of Bcl2 and enhanced oxidant injury...
  11. ncbi Signal integration in the endoplasmic reticulum unfolded protein response
    David Ron
    The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Rev Mol Cell Biol 8:519-29. 2007
    ..The arms of the UPR are integrated to provide a response that remodels the secretory apparatus and aligns cellular physiology to the demands imposed by ER stress...
  12. ncbi Oxidative stress and neurodegeneration: where are we now?
    Barry Halliwell
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neurochem 97:1634-58. 2006
    The brain and nervous system are prone to oxidative stress, and are inadequately equipped with antioxidant defense systems to prevent 'ongoing' oxidative damage, let alone the extra oxidative damage imposed by the neurodegenerative ..
  13. pmc Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
    Jisun Lee
    Center for Free Radical Biology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA
    Biochem J 441:523-40. 2012
    ..of mitochondria (also known as mitophagy) is controlled, and the impact of autophagic dysfunction on cellular oxidative stress. The present review highlights recent studies on redox signalling in the regulation of autophagy, in the ..
  14. pmc Pathways towards and away from Alzheimer's disease
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Nature 430:631-9. 2004
    ..But rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies...
  15. ncbi Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    Geert J P L Kops
    Department of Physiological Chemistry, University Medical Center Utrecht and Center for Biomedical Genetics, 3584 CG Utrecht, The Netherlands
    Nature 419:316-21. 2002
    ..the PKB-regulated Forkhead transcription factor FOXO3a (also known as FKHR-L1) protects quiescent cells from oxidative stress by directly increasing their quantities of manganese superoxide dismutase (MnSOD) messenger RNA and protein...
  16. ncbi Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    Vincenzo Bonifati
    Genetic Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
    Science 299:256-9. 2003
    ..The function of the DJ-1 protein remains unknown, but evidence suggests its involvement in the oxidative stress response. Our findings indicate that loss of DJ-1 function leads to neurodegeneration...
  17. ncbi Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004
    ..SIRT1 and the FOXO transcription factor FOXO3 formed a complex in cells in response to oxidative stress, and SIRT1 deacetylated FOXO3 in vitro and within cells...
  18. pmc Accelerated telomere shortening in response to life stress
    Elissa S Epel
    Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:17312-5. 2004
    ..psychological stress--both perceived stress and chronicity of stress--is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and ..
  19. ncbi FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    Zuzana Tothova
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 128:325-39. 2007
    ..Thus, FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for ..
  20. pmc Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    Paul D Ray
    Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, NC 27695 7633, USA
    Cell Signal 24:981-90. 2012
    ..b>Oxidative stress refers to the imbalance due to excess ROS or oxidants over the capability of the cell to mount an effective ..
  21. ncbi Role of oxidative modifications in atherosclerosis
    Roland Stocker
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    Physiol Rev 84:1381-478. 2004
    ..There is now a consensus that atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein oxidation in the vascular wall...
  22. pmc LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress
    Ha Nam Nguyen
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA
    Cell Stem Cell 8:267-80. 2011
    ..We found that DA neurons derived from G2019S-iPSCs showed increased expression of key oxidative stress-response genes and α-synuclein protein...
  23. pmc Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor
    Tadahiro Shimazu
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Science 339:211-4. 2013
    ..of HDAC by βOHB was correlated with global changes in transcription, including that of the genes encoding oxidative stress resistance factors FOXO3A and MT2...
  24. doi Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
    Keiko Taguchi
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
    Genes Cells 16:123-40. 2011
    ..Discovery and development of selective Nrf2 inhibitors should make a critical contribution to improved cancer therapy...
  25. doi Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants
    Sarvajeet Singh Gill
    Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Plant Physiol Biochem 48:909-30. 2010
    ..reactive and toxic and cause damage to proteins, lipids, carbohydrates and DNA which ultimately results in oxidative stress. The ROS comprises both free radical (O(2)(-), superoxide radicals; OH, hydroxyl radical; HO(2), perhydroxy ..
  26. ncbi Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
    Christopher P Baines
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Nature 434:658-62. 2005
    ..primary hepatocytes and fibroblasts isolated from Ppif null mice are largely protected from Ca2+-overload and oxidative stress-induced cell death...
  27. ncbi Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    Hideaki Kamata
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 120:649-61. 2005
    ..Antioxidant treatment also prevents TNFalpha-mediated fulminant liver failure without affecting liver regeneration...
  28. pmc Cellular defenses against superoxide and hydrogen peroxide
    James A Imlay
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Annu Rev Biochem 77:755-76. 2008
    ..Current research seeks to identify these, and bacteria comprise an exceptionally accessible experimental system that has provided many of the answers. This manuscript reviews recent developments and identifies remaining puzzles...
  29. ncbi Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Pharmacol Toxicol 47:89-116. 2007
    ..This review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses...
  30. ncbi Nrf2-Keap1 defines a physiologically important stress response mechanism
    Hozumi Motohashi
    Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology Japan Science and Technology Corporation, University of Tsukuba, Tsukuba 305 8577, Japan
    Trends Mol Med 10:549-57. 2004
    ..Furthermore, extensive studies have suggested that the Nrf2-Keap1 system contributes to protection against various pathologies, including carcinogenesis, liver toxicity, respiratory distress and inflammation...
  31. doi Mitochondria, oxidative stress and neurodegeneration
    Antonio Federico
    Department of Neurological, Neurosurgical and Behavioural Sciences, Medical School, University of Siena, Italy
    J Neurol Sci 322:254-62. 2012
    ..in ATP supply to cells through oxidative phosphorylation (OXPHOS), synthesis of key molecules and response to oxidative stress, as well as in apoptosis...
  32. pmc Oxidative stress, insulin signaling, and diabetes
    Justin L Rains
    Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 50:567-75. 2011
    b>Oxidative stress has been implicated as a contributor to both the onset and the progression of diabetes and its associated complications...
  33. doi Extending life span by increasing oxidative stress
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Free Radic Biol Med 51:327-36. 2011
    ....
  34. ncbi Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 30:1191-212. 2001
    Redox state is a term used widely in the research field of free radicals and oxidative stress. Unfortunately, it is used as a general term referring to relative changes that are not well defined or quantitated...
  35. pmc Posttranscriptional induction of two Cu/Zn superoxide dismutase genes in Arabidopsis is mediated by downregulation of miR398 and important for oxidative stress tolerance
    Ramanjulu Sunkar
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Plant Cell 18:2051-65. 2006
    ..CSD1 and CSD2 transcripts are induced in response to oxidative stress, but the regulatory mechanism of the induction is unknown...
  36. pmc Extension of chronological life span in yeast by decreased TOR pathway signaling
    R Wilson Powers
    Department of Genome Sciences and Medicine, The Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 20:174-84. 2006
    ..We propose that up-regulation of a highly conserved response to starvation-induced stress is important for life span extension by decreased TOR signaling in yeast and higher eukaryotes...
  37. ncbi Mitochondrial free radical generation, oxidative stress, and aging
    E Cadenas
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy University of Southern California, Los Angeles 90033, USA
    Free Radic Biol Med 29:222-30. 2000
    ..In this article we review current understandings of mitochondrial DNA, RNA, and protein modifications by oxidative stress and the enzymatic removal of oxidatively damaged products by nucleases and proteases...
  38. ncbi Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    Julie St-Pierre
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 127:397-408. 2006
    ..These studies reveal that PGC-1alpha is a broad and powerful regulator of ROS metabolism, providing a potential target for the therapeutic manipulation of these important endogenous toxins...
  39. ncbi Mitochondria, oxidative stress and cell death
    Martin Ott
    Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Apoptosis 12:913-22. 2007
    ..Conversely, mitochondrial antioxidant enzymes protect from apoptosis. Hence, there is accumulating evidence supporting a direct link between mitochondria, oxidative stress and cell death.
  40. ncbi Free radicals in the physiological control of cell function
    Wulf Dröge
    Division of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Physiol Rev 82:47-95. 2002
    ..Many of the ROS-mediated responses actually protect the cells against oxidative stress and reestablish "redox homeostasis...
  41. ncbi Diabetes, oxidative stress, and antioxidants: a review
    A C Maritim
    Moi University, College of Health Sciences, Eldoret, Kenya
    J Biochem Mol Toxicol 17:24-38. 2003
    Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus...
  42. pmc Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
    Ethan J Anderson
    Metabolic Institute for the Study of Diabetes and Obesity, East Carolina University, Greenville, North Carolina 27834, USA
    J Clin Invest 119:573-81. 2009
    ..Mitochondrial dysfunction and oxidative stress have been implicated in the disease process, but the underlying mechanisms are still unknown...
  43. pmc Consequences of oxidative stress in age-related macular degeneration
    Stuart G Jarrett
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, KY, USA
    Mol Aspects Med 33:399-417. 2012
    ..This review reassesses the consequences of oxidative stress in AMD and strategies for preventing or reversing oxidative damage in retinal tissues.
  44. pmc Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    Shinichi Someya
    Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, 53706, USA
    Cell 143:802-12. 2010
    ..and slows the progression of age-related hearing loss (AHL), a common age-related disorder associated with oxidative stress. Here, we report that CR reduces oxidative DNA damage in multiple tissues and prevents AHL in wild-type mice ..
  45. ncbi Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
    Joseph L Evans
    University of California at San Francisco, San Francisco, California 94143, USA
    Endocr Rev 23:599-622. 2002
    ..Studies with antioxidants such as vitamin E, alpha-lipoic acid, and N-acetylcysteine suggest that new strategies may become available to treat these conditions...
  46. ncbi RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
    S D Yan
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York 10032, USA
    Nature 382:685-91. 1996
    ..Increased expressing of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death...
  47. ncbi Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
    H Wang
    Neuroscience Laboratory, USDA ARS, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 27:612-6. 1999
    b>Oxidative stress (OS) has been implicated in various degenerative diseases in aging...
  48. pmc Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
    David Weismann
    Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
    Nature 478:76-81. 2011
    b>Oxidative stress and enhanced lipid peroxidation are linked to many chronic inflammatory diseases, including age-related macular degeneration (AMD)...
  49. ncbi Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    Tim J Schulz
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Cell Metab 6:280-93. 2007
    ..availability promotes formation of reactive oxygen species (ROS), induces catalase activity, and increases oxidative stress resistance and survival rates, altogether providing direct evidence for a hitherto hypothetical concept named ..
  50. doi p53 and metabolism
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, UK
    Nat Rev Cancer 9:691-700. 2009
    ....
  51. ncbi Endothelial nitric oxide synthase in vascular disease: from marvel to menace
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Circulation 113:1708-14. 2006
    ..This transformation of eNOS from a protective enzyme to a contributor to oxidative stress has been observed in several in vitro models, in animal models of cardiovascular diseases, and in patients ..
  52. pmc Antioxidants prevent health-promoting effects of physical exercise in humans
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
    Proc Natl Acad Sci U S A 106:8665-70. 2009
    ..Consistent with the concept of mitohormesis, exercise-induced oxidative stress ameliorates insulin resistance and causes an adaptive response promoting endogenous antioxidant defense ..
  53. doi Cytotoxicity and genotoxicity of silver nanoparticles in human cells
    P V AshaRani
    Department of Chemistry, Faculty of Science, National University of Singapore, Singapore 117543, Singapore 117597
    ACS Nano 3:279-90. 2009
    ..The toxicity was evaluated using changes in cell morphology, cell viability, metabolic activity, and oxidative stress. Ag-np reduced ATP content of the cell caused damage to mitochondria and increased production of reactive ..
  54. pmc Oxidative stress, inflammation, and cancer: how are they linked?
    Simone Reuter
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Free Radic Biol Med 49:1603-16. 2010
    Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer, diabetes, and cardiovascular,..
  55. pmc Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
    Dimitrios Anastasiou
    Beth Israel Deaconess Medical Center, Department of Medicine Division of Signal Transduction, Boston, MA 02115, USA
    Science 334:1278-83. 2011
    ..PKM2 was replaced with the Cys(358) to Ser(358) oxidation-resistant mutant exhibited increased sensitivity to oxidative stress and impaired tumor formation in a xenograft model...
  56. ncbi Oxidative stress shortens telomeres
    Thomas von Zglinicki
    Dept Gerontology, University of Newcastle, Wolfson Research Centre, General Hospital, Newcastle upon Tyne, UK
    Trends Biochem Sci 27:339-44. 2002
    ..Oxidative damage is repaired less well in telomeric DNA than elsewhere in the chromosome, and oxidative stress accelerates telomere loss, whereas antioxidants decelerate it...
  57. ncbi Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, Diabetes Endocrinology Center of Western New York, State University of New York at Buffalo, and Kaleida Health, Buffalo, NY 14209, USA
    Circulation 111:1448-54. 2005
  58. ncbi Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:533-42. 2005
    ..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity...
  59. doi Modulation of oxidative stress as an anticancer strategy
    Chiara Gorrini
    1 The Campbell Family Institute for Breast Cancer Research, University Health Network, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada 2
    Nat Rev Drug Discov 12:931-47. 2013
    The regulation of oxidative stress is an important factor in both tumour development and responses to anticancer therapies...
  60. pmc Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    Jennifer M A Tullet
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center Department of Pathology, Harvard Medical School Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
    Cell 132:1025-38. 2008
    ..The C. elegans transcription factor SKN-1 also defends against oxidative stress by mobilizing the conserved phase 2 detoxification response...
  61. pmc Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 2:2121-34. 2008
    ..subcellular localization, and toxic effects based on a test paradigm that was originally developed for oxidative stress and cytotoxicity in RAW 264.7 and BEAS-2B cell lines...
  62. pmc Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
    Ruben K Dagda
    Department of Pathology and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 284:13843-55. 2009
    ..of autophagy proteins Atg7 and LC3/Atg8 also decreased mitochondrial fragmentation without affecting oxidative stress, suggesting active involvement of autophagy in morphologic remodeling of mitochondria for clearance...
  63. doi How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
    Michael Ristow
    Dept of Human Nutrition, Institute of Nutrition, University of Jena, Germany
    Exp Gerontol 45:410-8. 2010
    ..culminates in subsequently increased stress resistance assumed to ultimately cause a long-term reduction of oxidative stress. This type of retrograde response has been named mitochondrial hormesis or mitohormesis, and may in addition ..
  64. pmc Autophagy suppresses tumorigenesis through elimination of p62
    Robin Mathew
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Cell 137:1062-75. 2009
    ..accumulation prevented damage resulting from autophagy defects indicating that failure to regulate p62 caused oxidative stress. Importantly, sustained p62 expression resulting from autophagy defects was sufficient to alter NF-kappaB ..
  65. doi Advances in metal-induced oxidative stress and human disease
    Klaudia Jomova
    Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University, SK 949 74 Nitra, Slovakia
    Toxicology 283:65-87. 2011
    ..Disruption of metal ion homeostasis may lead to oxidative stress, a state where increased formation of reactive oxygen species (ROS) overwhelms body antioxidant protection ..
  66. pmc Mediators of endoplasmic reticulum stress-induced apoptosis
    Eva Szegezdi
    Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, University Road, Galway, Ireland
    EMBO Rep 7:880-5. 2006
    ..We discuss how the activation of these molecules leads to the commitment of death and the mechanisms that are responsible for the final demise of the cell...
  67. pmc Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    Ubaldo E Martinez-Outschoorn
    Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:3256-76. 2010
    ..In this model, cancer cells induce oxidative stress in cancer-associated fibroblasts, which then acts as a "metabolic" and "mutagenic" motor to drive tumor-..
  68. doi Mitochondria and reactive oxygen species
    Alicia J Kowaltowski
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Free Radic Biol Med 47:333-43. 2009
    ..We discuss substrate-, tissue-, and organism-specific characteristics of mitochondrial oxidant generation. Several aspects of the physiological and pathological roles of mitochondrial ROS production are also addressed...
  69. ncbi Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
    Seong Woon Yu
    Department of Neurology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Science 297:259-63. 2002
    ..These data support a model in which PARP-1 activation signals AIF release from mitochondria, resulting in a caspase-independent pathway of programmed cell death...
  70. pmc Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:1752-61. 2004
    ..Obesity is a principal causative factor in the development of metabolic syndrome. Here we report that increased oxidative stress in accumulated fat is an important pathogenic mechanism of obesity-associated metabolic syndrome...
  71. ncbi Free radicals, metals and antioxidants in oxidative stress-induced cancer
    M Valko
    Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
    Chem Biol Interact 160:1-40. 2006
    ..The cumulative production of ROS/RNS through either endogenous or exogenous insults is termed oxidative stress and is common for many types of cancer cell that are linked with altered redox regulation of cellular ..
  72. pmc The response to heat shock and oxidative stress in Saccharomyces cerevisiae
    Kevin A Morano
    Department of Microbiology and Molecular Genetics, University of Texas Medical School and Graduate School of Biomedical Sciences, Houston, Texas 77030, USA
    Genetics 190:1157-95. 2012
    ..the response of the yeast Saccharomyces cerevisiae to two important environmental stresses: heat shock and oxidative stress. Both of these stresses are fundamental challenges that microbes of all types will experience...
  73. pmc Role of nrf2 in oxidative stress and toxicity
    Qiang Ma
    Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
    Annu Rev Pharmacol Toxicol 53:401-26. 2013
    ..Reactive oxygen and nitrogen species cause oxidative stress and are traditionally viewed as being harmful...
  74. pmc Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    Scott K Powers
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Physiol Rev 88:1243-76. 2008
    ..in 1978, and the past three decades have resulted in a large growth of knowledge regarding exercise and oxidative stress. Although the sources of oxidant production during exercise continue to be debated, it is now well ..
  75. ncbi Extension of murine life span by overexpression of catalase targeted to mitochondria
    Samuel E Schriner
    Department of Genome Sciences, University of Washington, Seattle, WA 91895, USA
    Science 308:1909-11. 2005
    ..These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals...
  76. ncbi Molecular pathways of neurodegeneration in Parkinson's disease
    Ted M Dawson
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Science 302:819-22. 2003
    ..Strategies aimed at restoring complex I activity, reducing oxidative stress and alpha-synuclein aggregation, and enhancing protein degradation may hold particular promise as powerful ..
  77. pmc Oxidative stress and diabetic complications
    Ferdinando Giacco
    Diabetes Research Center, Departments of Medicine Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461 1602, USA
    Circ Res 107:1058-70. 2010
    b>Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular...
  78. pmc Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    Akira Kobayashi
    Center for Tsukuba Advanced Research Alliance, Institute of Basic Medical Sciences, and JST ERATO Environmental Response Project, University of Tsukuba, Tsukuba 305 8575, Japan
    Mol Cell Biol 24:7130-9. 2004
    ..encoding phase 2 detoxifying enzymes and antioxidant stress proteins in response to electrophilic agents and oxidative stress. In the absence of such stimuli, Nrf2 is inactive owing to its cytoplasmic retention by Keap1 and rapid ..
  79. doi Melatonin as a natural ally against oxidative stress: a physicochemical examination
    Annia Galano
    Departamento de Química Universidad Autónoma Metropolitana Iztapalapa Col Vicentina Iztapalapa México D F México
    J Pineal Res 51:1-16. 2011
    b>Oxidative stress has been proven to be related to the onset of a large number of health disorders...
  80. pmc Selective killing of cancer cells by a small molecule targeting the stress response to ROS
    Lakshmi Raj
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nature 475:231-4. 2011
    ..small molecule to induce apoptosis selectively in cells that have a cancer genotype, by targeting a non-oncogene co-dependency acquired through the expression of the cancer genotype in response to transformation-induced oxidative stress.
  81. ncbi Oxidative DNA damage: mechanisms, mutation, and disease
    Marcus S Cooke
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE2 7LX, UK
    FASEB J 17:1195-214. 2003
    ....
  82. ncbi Oxidative stress in Parkinson's disease
    Peter Jenner
    Neurodegenerative Diseases Research Centre, GKT School of Biomedical Sciences, King s College, London, United Kingdom
    Ann Neurol 53:S26-36; discussion S36-8. 2003
    b>Oxidative stress contributes to the cascade leading to dopamine cell degeneration in Parkinson's disease (PD)...
  83. pmc Molecular mediators of hepatic steatosis and liver injury
    Jeffrey D Browning
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390 9046, USA
    J Clin Invest 114:147-52. 2004
    ..Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis...
  84. pmc The cell-non-autonomous nature of electron transport chain-mediated longevity
    Jenni Durieux
    The Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 144:79-91. 2011
    ..These results suggest that mitochondria may establish and perpetuate the rate of aging for the whole organism independent of cell-autonomous functions...
  85. pmc Mitochondrial formation of reactive oxygen species
    Julio F Turrens
    Department of Biomedical Sciences, University of South Alabama, Mobile, AL 36688, USA
    J Physiol 552:335-44. 2003
    ..We also discuss various physiological and pathological scenarios resulting from an increased steady state concentration of mitochondrial oxidants...
  86. doi ATM activation by oxidative stress
    Zhi Guo
    Howard Hughes Medical Institute, Department of Molecular Genetics and Microbiology, and Institute for Cellular and Molecular Biology ICMB, University of Texas at Austin, Austin, TX 78712, USA
    Science 330:517-21. 2010
    ..Cells lacking ATM are also hypersensitive to insults other than DSBs, particularly oxidative stress. We show that oxidation of ATM directly induces ATM activation in the absence of DNA DSBs and the MRN complex...
  87. doi Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    Anabela P Rolo
    Center for Neuroscience and Cell Biology, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 52:59-69. 2012
    ..consequent increased generation of reactive oxygen species (ROS) and reactive aldehydic derivatives causes oxidative stress and cell death, via ATP, NAD, and glutathione depletion and DNA, lipid, and protein damage...
  88. ncbi Biomarkers of oxidative damage in human disease
    Isabella Dalle-Donne
    Department of Biology, University of Milan, Milan, Italy
    Clin Chem 52:601-23. 2006
    ..has often been lacking because of recognized shortcomings with biomarkers and/or methods available to assess oxidative stress status in humans...
  89. pmc Autophagy-deficient mice develop multiple liver tumors
    Akito Takamura
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Genes Dev 25:795-800. 2011
    ..tumor cells originate autophagy-deficient hepatocytes and show mitochondrial swelling, p62 accumulation, and oxidative stress and genomic damage responses...
  90. ncbi Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    Michael T Lin
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, Room F 610, 525 East 68th Street, New York 10021, USA
    Nature 443:787-95. 2006
    ..Mutations in mitochondrial DNA and oxidative stress both contribute to ageing, which is the greatest risk factor for neurodegenerative diseases...
  91. ncbi Cellular response to oxidative stress: signaling for suicide and survival
    Jennifer L Martindale
    Cell Stress and Aging Section, Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, Maryland, USA
    J Cell Physiol 192:1-15. 2002
    ..in ROS, but ROS generation often exceeds the cell's antioxidant capacity, resulting in a condition termed oxidative stress. Host survival depends upon the ability of cells and tissues to adapt to or resist the stress, and repair or ..
  92. pmc Oxidative stress and microRNAs in vascular diseases
    Alessandra Magenta
    Istituto Dermopatico del Immacolata IRCCS, Vascular Pathology Laboratory, Via dei Monti di Creta 104, Rome 00167, Italy
    Int J Mol Sci 14:17319-46. 2013
    b>Oxidative stress has been demonstrated to play a causal role in different vascular diseases, such as hypertension, diabetic vasculopathy, hypercholesterolemia and atherosclerosis...
  93. pmc Neural mechanisms of ageing and cognitive decline
    Nicholas A Bishop
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 464:529-35. 2010
    ..Recent advances in the biology of ageing in model organisms, together with molecular and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline...
  94. pmc Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    Ryan Doonan
    Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 22:3236-41. 2008
    ..However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2 longevity and constitutive diapause, suggesting a signaling role for sod-4. Overall, these findings imply that O(2)(-) is not a major determinant of aging in C. elegans...
  95. pmc Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
    Jeremy M Van Raamsdonk
    Department of Biology, McGill University, Montreal, Quebec, Canada
    PLoS Genet 5:e1000361. 2009
    The oxidative stress theory of aging postulates that aging results from the accumulation of molecular damage caused by reactive oxygen species (ROS) generated during normal metabolism...
  96. ncbi The pathophysiology of cigarette smoking and cardiovascular disease: an update
    John A Ambrose
    Comprehensive Cardiovascular Center, Saint Vincent Catholic Medical Centers of New York, New York, New York 10011, USA
    J Am Coll Cardiol 43:1731-7. 2004
    ..Recent experimental and clinical data support the hypothesis that cigarette smoke exposure increases oxidative stress as a potential mechanism for initiating cardiovascular dysfunction.
  97. pmc Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:14670-5. 2009
    ..3xTg-AD mice also exhibited increased oxidative stress as manifested by increased hydrogen peroxide production and lipid peroxidation...
  98. pmc Crosstalk of reactive oxygen species and NF-κB signaling
    Michael J Morgan
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, RM1130, Bethesda, MD 20892, USA
    Cell Res 21:103-15. 2011
    ..Here we review the regulation of ROS levels by NF-κB targets and various ways in which ROS have been proposed to impact NF-κB signaling pathways...
  99. ncbi Hereditary early-onset Parkinson's disease caused by mutations in PINK1
    Enza Maria Valente
    CSS IRCCS, Mendel Institute, Viale Regina Margherita 261, 00198 Rome, Italy
    Science 304:1158-60. 2004
    ..These data provide a direct molecular link between mitochondria and the pathogenesis of PD...
  100. ncbi Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 282:11590-601. 2007
    b>Oxidative stress is a major aspect of Alzheimer disease (AD) pathology. We have investigated the relationship between oxidative stress and neuronal binding of Abeta oligomers (also known as ADDLs)...
  101. ncbi Negative control of p53 by Sir2alpha promotes cell survival under stress
    J Luo
    Institute of Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Cell 107:137-48. 2001
    ..Furthermore, Sir2alpha represses p53-dependent apoptosis in response to DNA damage and oxidative stress, whereas expression of a Sir2alpha point mutant increases the sensitivity of cells in the stress response...

Research Grants74

  1. ALCOHOL-INDUCED HEPATIC P450s IN HCV/HIV OXIDATE INJURY
    STEVEN SHEDLOFSKY; Fiscal Year: 2003
    ..Substantial evidence suggests that oxidative stress plays an important role in the severity and progression of the HCV-induced injury...
  2. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..with a combination of RS-Alpha-Lipoic Acid (LA) and L-Carnitine (ALCAR) will produce a measurable decline in oxidative stress in patients with thalassemia, 5) Increased platelet activation and hypercoagulability is the primary cause of ..
  3. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..acids (FFAs), ketone bodies, triacylglcyerols (TAG), cholesterol, blood pH, and markers of inflammation and oxidative stress in mice fed a high saturated fat diet;(b) determine the molecular mechanisms responsible for the increases in ..
  4. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..accompany large negative intrathoracic pressure swings, and repetitive hypoxia/reoxygenation associated with oxidative stress and endothelial dysfunction have also been implicated...
  5. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oxidative stress and glutathione (GSH) imbalance are major contributors to the pathogenesis of diabetic nephropathy...
  6. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..Iron-mediated oxidative stress and increased levels of labile plasma iron (LPI), may worsen intravascular hemolysis and impair endothelial ..
  7. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..attenuate the excitotoxic cascade of free-radical formation by preserving mitochondrial function and reducing oxidative stress and energetic crisis, and (2) the oxime-bearing fragment would salvage the OP-bound inactivated AChE and ..
  8. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..research has implicated a heightened renin-angiotensin-aldosterone system (RAAS) and associated enhanced oxidative stress in the pathogenesis and cardiovascular complications of insulin resistance in people with diabetes and ..
  9. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Of particular interest are adaptive changes in proteins associated with metabolism, oxidative stress, and cell death...
  10. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..b>Oxidative stress due to chronic inflammation is a dominant force in the progression of chronic liver disease (CLD) and ..
  11. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although oxidative stress is implicated in both acute acetaminophen-induced liver failure and chronic liver diseases, cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic ..
  12. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..In Aim 2, we will test the hypothesis that lower NADPH availability increases mitochondrial oxidative stress, thereby leads to impaired fuel oxidation...
  13. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..inhaled oxidants, specifically, the influence of air pollution mixtures on markers of airway inflammation and oxidative stress. The training portion of this application will be critically important to achieve these goals...
  14. ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESIS
    Enrique A Mesri; Fiscal Year: 2013
    ..effectors are molecules actively involved in KS viral oncogenesis, and suggest that Rac1 signaling and oxidative stress could be attractive KS chemopreventive and therapeutic targets...
  15. Epigenetic mechanisms relevant to the pathogenesis of ALS
    Neil W Kowall; Fiscal Year: 2013
    ..Despite this, the cause of motor neuron death is unknown and the role of mutant SOD1 in the generation of oxidative stress in ALS has not been established...
  16. Regulation of ER stress-induced cell death
    Randal J Kaufman; Fiscal Year: 2013
    ..In pursuit of this goal, we have demonstrated that islets from Chop-/- mice are protected from oxidative stress that occurs upon accumulation of unfolded proteins in the ER...
  17. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013
    ..Chronic alcohol ingestion increases Nox enzyme levels, leading to AM oxidative stress and dysfunction...
  18. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..Among intestinal commensals E. faecalis is unique in generating extracellular superoxide, promoting oxidative stress, and damaging DNA...
  19. REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASES
    Melanie H Cobb; Fiscal Year: 2012
    ..The Ste20 protein kinase oxidative stress responsive 1 (OSR1) and its homolog the serine, proline, alanine-rich kinase (SPAK) bind to WNK1 in cells, ..
  20. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    ..These mouse models will also be used to determine if oxidative stress and mitochondrial dysfunction will increase the risk for insulin resistance and lipotoxicity...
  21. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..is a critical need to develop methods to evaluate their toxicity, especially at low concentrations that cause oxidative stress and adverse long-term health effects...
  22. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..of nervous system CGRP/ RAMP1 receptors abrogates Ang-II induced dysautonomia and hypertension by reducing oxidative stress. Our preliminary data indicate that just a 1...
  23. Mitochondrial Dysfunction and Adipose Insulin Resistance
    David A Bernlohr; Fiscal Year: 2013
    ..provided by applicant): A variety of animal, cell culture and molecular studies have correlated increased oxidative stress and the accumulation of reactive oxygen species (ROS) such as superoxide anion and hydroxyl radicals to type ..
  24. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..To date, however, the GAS genes regulated in response to oxidative stress, including those regulated by PerR, have not been defined...
  25. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..Multiple mechanisms such as lipotoxicity, glucotoxicity, oxidative stress, impaired myocardial calcium homeostasis and impaired insulin signaling have been implicated...
  26. Role and Regulation of INrf2
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..INrf2 study is of considerable importance in prevention of xenobiotic, nutrient and radiation-induced oxidative stress. INrf2 serves as a sensor of xenobiotic-induced oxidative stress and initiates a signal cascade that leads to ..
  27. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..b>Oxidative stress in cultured smooth muscle cells upregulated redox survival signaling via PI3-kinase and Akt expression and ..
  28. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..award period, the candidate will test the hypotheses that 1) Mitochondrial dysfunction is associated with oxidative stress during cardiac surgery and predicts AKI following cardiac surgery (Aim 1) and that 2) Treatment with a ..
  29. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..Biopsy studies and animal studies suggest that amyloid light chains cause oxidative stress leading to tissue damage or dysfunction in colon and cardiac tissues...
  30. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Inflammatory markers and markers of oxidative stress, including interleukin (IL)-6, -8 and -10, myeloperoxidase (MPO), and matrix metalloproteinase-9 (MMP-9) will ..
  31. Prevention of UV-induced carcinogenesis by cyanidin-3-glucoside
    Xianglin Shi; Fiscal Year: 2013
    ..The overall hypothesis of this application is that C3G functions as an antioxidant and inhibits oxidative stress, activation of transcription factors, and inflammatory signaling proteins, leading to protection against UVB-..
  32. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..We propose to create a new system to detect redox status and oxidative stress in specific cells within intact tissues, using a novel combination of existing methods...
  33. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..Thus, the inherent chemical nature of L-DOPA as an initiator of oxidative stress and the neuroimaging results of the clinical trial have left the question unanswered whether L-DOPA treatment ..
  34. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..cofactors that may contribute to the failure of anti-HCV therapy, including obesity, diabetes, alcohol abuse, oxidative stress, cigarette smoking and environmental pollutants...
  35. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    ..Nanoceria effects on specific genes involved in oxidative stress, inflammation and neovascularization will be analyzed using confocal microscopy, Western blots and PCR arrays...
  36. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..The oxidative stress of pregnancy is increased further in preeclampsia where we identified increased placental expression of NADPH ..
  37. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..model of PPHN, induced by prenatal ductal constriction demonstrated a decrease in NO release and increase in oxidative stress in pulmonary arteries...
  38. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..these findings led us to hypothesize that woodchucks undergo natural adaptations in winter by reducing oxidative stress (ROS levels) and thus ROS- induced (oxidized) CaMKII activity levels, which benefits the woodchucks and ..
  39. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2013
    ..addition to suboptimal biosynthesis of high-energy phosphates, lack of frataxin also heightens sensitivity to oxidative stress, presumed to be mediated by free or loosely bound iron. Tissue damage in FRDA is very diverse...
  40. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..homeostasis in the adult or aging skeleton, is perturbed by mechanisms that involve decreased defense against oxidative stress and/or increased production of Reactive Oxygen Species (ROS)...
  41. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..several virulence phenotypes including LOS outer core modification, serum resistance, and resistance to oxidative stress. These virulence properties are likely critical during the transition from the airway surface to interstitial ..
  42. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..The first clue was that IMCL was completely independent of insulin sensitivity in African Americans, while oxidative stress related to lipid peroxidation in muscle was predictive of insulin resistance in both European- and African-..
  43. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..Determine the association of baseline 25-OH D and PTH levels with baseline levels of circulating markers of oxidative stress (total isoprostanes, nuclear factor kappa beta) and free radicals (nitrotyrosine, dityrosine, chlorotyrosine),..
  44. Analysis of gene regulation of Vibrio cholerae during infection
    Jun Zhu; Fiscal Year: 2013
    ..Next we will examine how AphB is modified by reactive nitrogen species (RNS), such as nitric oxide (NO), and oxidative stress from reactive oxygen species (ROS) generated in vivo and how these modifications affect AphB functionality, ..
  45. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..ATM also plays important roles in the control of oxidative stress, and ATM deficiency leads to increased levels of highly reactive oxygen species as well as defects in ..
  46. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..examined to date in the pathways that regulate response of the cell to insulin/insulin-like growth factor, oxidative stress and inflammatory agents...
  47. Metabolic mechanisms of antiestrogen resistance in breast cancer
    UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2013
    ..Specifically, I will test drugs that increase or decrease OXPHOS, inhibit glycolysis or inhibit oxidative stress to determine their effects on carcinoma cell growth...
  48. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..New data on the ACE-ACE2 balance and central cellular signaling pathways will be covered. Oxidative stress is now thought to be part of normal cell signaling and in excess to contribute to activation of excitable ..
  49. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012
    ..Alcohol alters mitochondrial function and leads to oxidative stress. We have demonstrated that alcohol-induced oxidative stress down-regulates hepcidin transcription without ..
  50. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..Based on preliminary studies, it is probable that iron-dependent radical chemistry during oxidative stress leads to lysosomal membrane disruption and release of chelatable iron into the cytosol...
  51. Therapeutic Effect of a Novel Antioxidant on Degenerative Eye Disorders
    Nuran Ercal; Fiscal Year: 2012
    ..The importance of oxidative stress damage in the pathogenesis of AREDs has been established for cataracts and the dry form of age-related ..
  52. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..b>Oxidative stress and reduced nitric oxide (NO) bioavailability are important contributors to the accelerated vascular disease ..
  53. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..This is "oxidative stress" as a result of a chronic or acute rise in Reactive Oxygen Species (ROS)...
  54. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although oxidative stress is a hallmark of heart failure (HF), clinical trials with antioxidants targeting first generation reactive oxygen species (ROS) such as O2/ and H2O2 have not yielded ..
  55. Complex I: Role of L Subunit in Proton Translocation
    Steven B Vik; Fiscal Year: 2011
    ..In humans Complex I plays additional roles in the mitochondrion related to oxidative stress, cell signaling, and cell death...
  56. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aging is associated with increased inflammation and oxidative stress leading to progressive decline in musculoskeletal tissue mass, quality and function which increases the risk of falls and fractures ..
  57. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..in various forms of pollution and metabolized by cytochromes P450 to intermediates that damage DNA and cause oxidative stress. Repeated exposure of vSMCs to BaP in vivo or in vitro induces atherosclerotic changes within the vascular ..
  58. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..deoxy-delta 12,14-prostaglandin J2) or providing anti-oxidant protection against heme-induced oxidative stress (N-Acethil cystein, desferoxamine) will be tested as well...
  59. Mitochondrial Dysfunction and Adipose Insulin Resistance
    DAVID BERNLOHR; Fiscal Year: 2009
    ..Insulin Resistance Abstract A variety of animal, cell culture and molecular studies have correlated increased oxidative stress and the accumulation of reactive oxygen species (ROS) such as superoxide anion and hydroxyl radicals to type ..
  60. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..As both toxic effects of cyanide by inhibition of CcOX and potentiation of NMDARs converge on oxidative stress, one possible strategy for the development of neuroprotective drugs for cyanide poisoning is to search for ..
  61. CPG METHYLATION AND MUTATION
    Gerd P Pfeifer; Fiscal Year: 2013
    ..We will investigate if chemical carcinogens, or endogenous processes such as inflammation and oxidative stress can induce changes in DNA methylation...
  62. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..Specifically, each causes oxidative stress and depletion of the anti-oxidant glutathione within the airways...
  63. Mechanisms of Stem Cell Self-Renewal and Aging
    PAUL CHRISTIAN SCHILLER; Fiscal Year: 2013
    ..models now strongly suggest that senescence, and the associated alterations in cell signaling and increase in oxidative stress, constitute the physiological and molecular consequences of hormone deficiency and osteoporosis...
  64. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2010
    ..It is believed that the underlying mechanism of PD involves oxidative stress leading to cellular apoptosis...
  65. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Oxidative stress resulting from chemical exposure has been implicated as a contributing risk factor for a range of neurodegenerative diseases...
  66. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
    ..and heparin increased blood pressure (BP) about l4/8 mmHg and elevated plasma F2-isoprostanes, an index of oxidative stress, p<O.O5. The rise in NEFAs correlated with the increase of plasma F2-isoprostanes NEFAs (N=30, r=O...
  67. Molecular Regulation of Alpha-Synuclein Misfolding and Toxicity in Two Yeast Mode
    SHUBHIK DEBBURMAN; Fiscal Year: 2009
    ..alone does not cause toxicity, but the addition of either proteasomal dysfunction or mitochondrial oxidative stress is synthetic lethal. This lethality does not correlate well with a-synuclein aggregation...
  68. Molecular mechanisms of oxidative stress resistance in an animal model of aging w
    Sarah Milton; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The effects of reactive oxygen species (ROS) and oxidative stress on protein organization, cellular homeostasis, and apoptosis are recognized as key factors in aging and senescence, and ROS damage is ..
  69. Biomarkers of Oxidative Stress in Parkinson's Disease
    M Flint Beal; Fiscal Year: 2010
    ..Development and validation of biomarkers of oxidative stress that could be used to assess the antioxidant effects of dietary supplements in vivo...
  70. CNS INJURY AND EDEMA RESEARCH CENTER
    Pak Chan; Fiscal Year: 2007
    b>Oxidative stress generated during cerebral ischemia and reperfusion is a critical event leading to damage of the neurovascular unit that causes blood-brain barrier disruption, with secondary vasogenic edema and hemorrhagic ..
  71. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
    ..revision also serves to create new research objectives to explore the associations of nicotine metabolism and oxidative stress genetics outside of the scope of the parent grant, and will be completed in less than one year...
  72. TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGE
    Arlan Richardson; Fiscal Year: 2001
    The oxidative stress hypothesis of aging (or the free radical hypothesis as it was first proposed) is currently one the most popular explanations for how aging occurs at the biochemical level...
  73. Dietary Cysteine:Conceptal Response to Oxidative Stress
    Craig Harris; Fiscal Year: 2002
    ..implicated as an important factor in the ability to withstand chemical and environmental insults that elicit oxidative stress. Without adequate free cysteine, the ability to restore glutathione that is lost due to oxidation is ..
  74. mtDNA mutation/heteroplasmy: a sensitive functional biomarker of oxidative stress
    Bruce N Ames; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Many biomarkers are responsive to oxidative stress and modulating effects of antioxidant dietary supplements, but the disease relevance of these markers is uncertain because of the lack of known ..