glycolysis

Summary

Summary: A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.

Top Publications

  1. pmc Understanding the Warburg effect: the metabolic requirements of cell proliferation
    Matthew G Vander Heiden
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 324:1029-33. 2009
  2. ncbi Cancer cell metabolism: Warburg and beyond
    Peggy P Hsu
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Cambridge, MA 02142, USA
    Cell 134:703-7. 2008
  3. ncbi The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    Heather R Christofk
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 452:230-3. 2008
  4. ncbi TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    Karim Bensaad
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Cell 126:107-20. 2006
  5. ncbi Otto Warburg's contributions to current concepts of cancer metabolism
    Willem H Koppenol
    Institute of Inorganic Chemistry, Swiss Federal Institute of Technology, Zurich, Switzerland chem ethz ch
    Nat Rev Cancer 11:325-37. 2011
  6. ncbi Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
  7. pmc Tumor suppressors and cell metabolism: a recipe for cancer growth
    Russell G Jones
    Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Quebec, H3A 1A3, Canada
    Genes Dev 23:537-48. 2009
  8. ncbi Glycolysis inhibition for anticancer treatment
    H Pelicano
    The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 25:4633-46. 2006
  9. pmc Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    Ralph J DeBerardinis
    Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Room 450, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 104:19345-50. 2007
  10. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004

Research Grants

Detail Information

Publications348 found, 100 shown here

  1. pmc Understanding the Warburg effect: the metabolic requirements of cell proliferation
    Matthew G Vander Heiden
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 324:1029-33. 2009
    ..phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect...
  2. ncbi Cancer cell metabolism: Warburg and beyond
    Peggy P Hsu
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Cambridge, MA 02142, USA
    Cell 134:703-7. 2008
    Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear...
  3. ncbi The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    Heather R Christofk
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 452:230-3. 2008
    ..This persistence of high lactate production by tumours in the presence of oxygen, known as aerobic glycolysis, was first noted by Otto Warburg more than 75 yr ago...
  4. ncbi TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    Karim Bensaad
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Cell 126:107-20. 2006
    ..We have identified a p53-inducible gene named TIGAR (TP53-induced glycolysis and apoptosis regulator)...
  5. ncbi Otto Warburg's contributions to current concepts of cancer metabolism
    Willem H Koppenol
    Institute of Inorganic Chemistry, Swiss Federal Institute of Technology, Zurich, Switzerland chem ethz ch
    Nat Rev Cancer 11:325-37. 2011
    ..However, this increase in aerobic glycolysis in cancer cells is often erroneously thought to occur instead of mitochondrial respiration and has been ..
  6. ncbi Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
    ..Using a novel approach to measure cellular metabolic rates in vitro, the bioenergetic basis of this increased glycolysis and reduced mitochondrial respiration was investigated in two human cancer cell lines, H460 and A549...
  7. pmc Tumor suppressors and cell metabolism: a recipe for cancer growth
    Russell G Jones
    Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Quebec, H3A 1A3, Canada
    Genes Dev 23:537-48. 2009
    ..In this review, we consider the potential role of tumor suppressors as metabolic regulators...
  8. ncbi Glycolysis inhibition for anticancer treatment
    H Pelicano
    The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 25:4633-46. 2006
    Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply...
  9. pmc Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    Ralph J DeBerardinis
    Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Room 450, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 104:19345-50. 2007
    ..Here, we used 13C NMR spectroscopy to examine the metabolism of glioblastoma cells exhibiting aerobic glycolysis. In these cells, the tricarboxylic acid (TCA) cycle was active but was characterized by an efflux of substrates ..
  10. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
    ..A near-universal property of primary and metastatic cancers is upregulation of glycolysis, resulting in increased glucose consumption, which can be observed with clinical tumour imaging...
  11. pmc Brick by brick: metabolism and tumor cell growth
    Ralph J DeBerardinis
    Department of Cancer Biology, Abramson Cancer Center and Abramson Family Cancer Research Institute, University of Pennsylvania, 1600 Penn Tower, 3400 Spruce Street, Philadelphia, PA 19104, United States
    Curr Opin Genet Dev 18:54-61. 2008
    ..Classical work in tumor cell metabolism focused on bioenergetics, particularly enhanced glycolysis and suppressed oxidative phosphorylation (the 'Warburg effect')...
  12. pmc Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    Pierre Sonveaux
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    J Clin Invest 118:3930-42. 2008
    ..alpha-cyano-4-hydroxycinnamate (CHC) or siRNA in these cells induced a switch from lactate-fueled respiration to glycolysis. A similar switch from lactate-fueled respiration to glycolysis by oxygenated tumor cells in both a mouse model ..
  13. pmc Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue
    Diana Whitaker-Menezes
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:4047-64. 2011
    ..in the tumor microenvironment then leads to autophagy-driven catabolism, mitochondrial dys-function, and aerobic glycolysis. This, in turn, produces high-energy nutrients (such as L-lactate, ketones, and glutamine) that drive the ..
  14. pmc Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis
    Stephanos Pavlides
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA
    Antioxid Redox Signal 16:1264-84. 2012
    ..the "fundamental basis" of cancer, based on his observations that tumors displayed a metabolic shift toward glycolysis. In 1963, Christian de Duve, another Nobel Laureate, first coined the phrase auto-phagy, derived from the Greek ..
  15. ncbi Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    Sophia Y Lunt
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Cell Dev Biol 27:441-64. 2011
    Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells...
  16. ncbi Targeting metabolic transformation for cancer therapy
    Daniel A Tennant
    Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow, UK
    Nat Rev Cancer 10:267-77. 2010
    ..This Review highlights pathways against which there are already drugs in different stages of development and also discusses additional druggable targets...
  17. pmc Evidence for an alternative glycolytic pathway in rapidly proliferating cells
    Matthew G Vander Heiden
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 329:1492-9. 2010
    ..The M2 isoform of pyruvate kinase (PKM2) promotes the metabolism of glucose by aerobic glycolysis and contributes to anabolic metabolism...
  18. pmc Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
    Frank Weinberg
    Division of Pulmonary and Critical Care, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:8788-93. 2010
    ..tumor cells have defects in mitochondrial oxidative phosphorylation and therefore rely on high levels of aerobic glycolysis as the major source of ATP to fuel cellular proliferation (the Warburg effect)...
  19. ncbi The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    Stephanos Pavlides
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 8:3984-4001. 2009
    ..Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) in neighboring stromal fibroblasts...
  20. ncbi Hypoxia, HIF1 and glucose metabolism in the solid tumour
    Nicholas C Denko
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Rev Cancer 8:705-13. 2008
    ..However, it remains unclear how this 'aerobic glycolysis', originally described by Otto Warburg, offers tumour cells a growth advantage...
  21. pmc HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
    Charles J David
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 463:364-8. 2010
    ..This long-observed phenomenon is known as aerobic glycolysis, and is important for cell growth...
  22. pmc Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
    Anne Le
    Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:2037-42. 2010
    ....
  23. ncbi Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells
    Rodrigue Rossignol
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA
    Cancer Res 64:985-93. 2004
    ..availability were examined on a human cancer cell line (HeLa), focusing specifically on its ability to use glycolysis versus oxidative phosphorylation, and the effect that energy substrate type has on mitochondrial composition, ..
  24. pmc Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
    Gloria Bonuccelli
    Department of Stem Cell Biology and Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:3506-14. 2010
    ..In this scheme, cancer-associated fibroblasts undergo aerobic glycolysis and the resulting energy-rich metabolites are then transferred to epithelial cancer cells, where they enter the ..
  25. ncbi Cancer's molecular sweet tooth and the Warburg effect
    Jung whan Kim
    Division of Hematology, Department of Medicine, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 66:8927-30. 2006
    ..Molecular advances in this area may reveal tactics to exploit the cancer cell's "sweet tooth" for cancer therapy...
  26. ncbi Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    Rui Hua Xu
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:613-21. 2005
    Cancer cells generally exhibit increased glycolysis for ATP generation (the Warburg effect) due in part to mitochondrial respiration injury and hypoxia, which are frequently associated with resistance to therapeutic agents...
  27. ncbi Oncogenic alterations of metabolism
    C V Dang
    Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Biochem Sci 24:68-72. 1999
    ..studies showed that tumors have altered metabolic profiles and display high rates of glucose uptake and glycolysis. Although these metabolic changes are not the fundamental defects that cause cancer, they might confer a common ..
  28. pmc Targeting glucose metabolism for cancer therapy
    Robert B Hamanaka
    Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    J Exp Med 209:211-5. 2012
    ..In this minireview, we discuss the benefits that high levels of glycolysis provide for tumor cells, as well as several key enzymes required by cancer cells to maintain this high level of ..
  29. ncbi Energy metabolism in tumor cells
    Rafael Moreno-Sanchez
    Instituto Nacional de Cardiologia, Departamento de Bioquimica, Juan Badiano No 1, Tlalpan, Mexico DF 14080, Mexico
    FEBS J 274:1393-418. 2007
    In early studies on energy metabolism of tumor cells, it was proposed that the enhanced glycolysis was induced by a decreased oxidative phosphorylation...
  30. pmc Dynamics of the cellular metabolome during human cytomegalovirus infection
    Joshua Munger
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 2:e132. 2006
    ..As the infection progressed, the levels of metabolites involved in glycolysis, the citric acid cycle, and pyrimidine nucleotide biosynthesis markedly increased...
  31. ncbi Quantitative metabolome analysis using capillary electrophoresis mass spectrometry
    Tomoyoshi Soga
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997 0017, Japan
    J Proteome Res 2:488-94. 2003
    ..subtilis sporulation...
  32. pmc Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors
    Ubaldo E Martinez-Outschoorn
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:2504-20. 2011
    ..resulting in compartmentalized cellular catabolism, loss of mitochondrial function, and the onset of aerobic glycolysis, in the tumor stroma...
  33. pmc Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
    Taro Hitosugi
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Sci Signal 2:ra73. 2009
    ..Our findings suggest that tyrosine phosphorylation regulates PKM2 to provide a metabolic advantage to tumor cells, thereby promoting tumor growth...
  34. pmc Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect
    David A Scott
    Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:42626-34. 2011
    ..Altogether, this study, which is the first comprehensive comparative analysis of metabolism in melanoma cells, provides a foundation for targeting metabolism for therapeutic benefit in melanoma...
  35. pmc The molecular determinants of de novo nucleotide biosynthesis in cancer cells
    Xuemei Tong
    Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Curr Opin Genet Dev 19:32-7. 2009
    ....
  36. pmc Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment
    Ubaldo E Martinez-Outschoorn
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Philadelphia, PA, USA
    Int J Biochem Cell Biol 43:1045-51. 2011
    ..Then, stromal cells are forced to undergo aerobic glycolysis, and produce energy-rich nutrients (such as lactate and ketones) to "feed" cancer cells...
  37. ncbi Fuel feeds function: energy metabolism and the T-cell response
    Casey J Fox
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Immunol 5:844-52. 2005
    ..In this Review, we describe how T cells actively acquire metabolic substrates from their environment to meet these energy demands and respond appropriately to pathogens...
  38. pmc Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
    Rebecca Lock
    Department of Pathology, University of California, San Francisco Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA
    Mol Biol Cell 22:165-78. 2011
    ..Overall, increased glycolysis in autophagy-competent cells facilitates Ras-mediated adhesion-independent transformation, suggesting a unique ..
  39. ncbi Lactate: a metabolic key player in cancer
    Franziska Hirschhaeuser
    Institute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Cancer Res 71:6921-5. 2011
    Increased glucose uptake and accumulation of lactate, even under normoxic conditions (i.e., aerobic glycolysis or the Warburg Effect), is a common feature of cancer cells...
  40. ncbi Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
    Asami Hagiwara
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Cell Metab 15:725-38. 2012
    ..and reduced glucokinase and SREBP1c activity in the liver, leading to constitutive gluconeogenesis, and impaired glycolysis and lipogenesis, suggesting that the mTORC2-deficient liver is unable to sense satiety...
  41. pmc Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
    Amparo Wolf
    The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada
    J Exp Med 208:313-26. 2011
    Proliferating embryonic and cancer cells preferentially use aerobic glycolysis to support growth, a metabolic alteration commonly referred to as the "Warburg effect...
  42. ncbi The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells
    Alessandro Prigione
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Stem Cells 28:721-33. 2010
    ....
  43. pmc E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation
    Angeles Almeida
    Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Leon, 37007 Salamanca, Spain
    Proc Natl Acad Sci U S A 107:738-41. 2010
    Cell proliferation is known to be accompanied by activation of glycolysis. We have recently discovered that the glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, isoform 3 (PFKFB3), is degraded by the E3 ..
  44. ncbi Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation
    Stephanos Pavlides
    Departments of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:2201-19. 2010
    ..loss of Cav-1 induces oxidative stress, which mimics a constitutive pseudo-hypoxic state, leading to (1) aerobic glycolysis and (2) inflammation in the tumor stromal microenvironment...
  45. pmc Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
    Qian Sun
    State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China
    Proc Natl Acad Sci U S A 108:4129-34. 2011
    Although aerobic glycolysis (the Warburg effect) is a hallmark of cancer, key questions, including when, how, and why cancer cells become highly glycolytic, remain less clear...
  46. pmc Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics
    Ubaldo E Martinez-Outschoorn
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1271-86. 2011
    ..Importantly, this powerful new approach directly links cancer cell metabolism with clinical outcome, and new therapeutic strategies for inhibiting the TCA cycle and mitochondrial oxidative phosphorylation in cancer cells...
  47. pmc Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
    E D Michelakis
    Department of Medicine, University of Alberta, Edmonton, Canada
    Br J Cancer 99:989-94. 2008
    The unique metabolism of most solid tumours (aerobic glycolysis, i.e...
  48. ncbi Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma?
    Caroline Jose
    MRGM, Laboratoire Maladies Rares Génétique et Métabolisme, F 33076 Bordeaux, France
    Biochim Biophys Acta 1807:552-61. 2011
    ..We conclude on the importance of a dynamic view of tumor bioenergetics...
  49. pmc Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
    Claudia Capparelli
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:2285-302. 2012
    ..autophagic phenotype, with features of mitophagy, mitochondrial dysfunction and a shift toward aerobic glycolysis, resulting in L-lactate and ketone body production...
  50. pmc Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming
    Clifford D L Folmes
    Center for Regenerative Medicine and Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cell Metab 14:264-71. 2011
    ..Stimulation of glycolysis promoted, while blockade of glycolytic enzyme activity blunted, reprogramming efficiency...
  51. pmc MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis
    Christopher L Sans
    Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, 2000 Circle of Hope, Room 4365, Salt Lake City, UT 84112 5550, USA
    Mol Cell Biol 26:4863-71. 2006
    ..Consistent with its regulation of glycolytic targets, MondoA is both necessary and sufficient for glycolysis. We propose that MondoA communicates information about the intracellular energy state between the mitochondria ..
  52. ncbi The CD28 signaling pathway regulates glucose metabolism
    Kenneth A Frauwirth
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 16:769-77. 2002
    ..Although T cells increase glucose uptake and glycolysis during an immune response, the signaling pathways that regulate these increases remain largely unknown...
  53. pmc No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
    Katharina Bluemlein
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Oncotarget 2:393-400. 2011
    The Warburg effect describes the circumstance that tumor cells preferentially use glycolysis rather than oxidative phosphorylation for energy production...
  54. pmc Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect
    Tomer Shlomi
    Computer Science Department, Technion Israel Institute of Technology, Haifa, Israel
    PLoS Comput Biol 7:e1002018. 2011
    ..phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily on more efficient energy production through ..
  55. pmc Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
    Markus Ralser
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    J Biol 6:10. 2007
    ..Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an important role...
  56. pmc Transcriptional response of Candida albicans upon internalization by macrophages
    Michael C Lorenz
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Eukaryot Cell 3:1076-87. 2004
    ....
  57. pmc Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
    Brian P Dranka
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
    Free Radic Biol Med 48:905-14. 2010
    ..These data are consistent with a critical role for the mitochondrial reserve capacity in endothelial cells in responding to oxidative stress...
  58. ncbi 2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma
    Silvia Ramírez-Peinado
    Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet, Barcelona, Spain
    Cancer Res 71:6796-806. 2011
    ..Together, our findings suggest that glycolysis inhibitors such as 2-DG may be highly effective in treating alveolar rhabdomyosarcoma and that Noxa could offer ..
  59. pmc CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth
    Claudia Capparelli
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:2272-84. 2012
    ..results in the metabolic reprogramming of cancer-associated fibroblasts, with the induction of autophagy and glycolysis. However, it remains unknown if activation of the TGF-β / CTGF pathway regulates the metabolism of cancer-..
  60. ncbi Causes and consequences of increased glucose metabolism of cancers
    Robert J Gillies
    University of Arizona, Tucson, Arizona, USA
    J Nucl Med 49:24S-42S. 2008
    ..In other words, we will ask not only "How do cancers have high glycolysis?" but also, "Why?" We believe that the insights gained from answering the latter question support the conclusion ..
  61. pmc The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
    Chia Hsin Chan
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell 149:1098-111. 2012
    ..Skp2 deficiency impairs Akt activation, Glut1 expression, glucose uptake and glycolysis, and breast cancer progression in various tumor models...
  62. ncbi Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    Valeria R Fantin
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 9:425-34. 2006
    ..These results demonstrate that LDH-A plays a key role in tumor maintenance...
  63. ncbi Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
    Alisdair R Fernie
    Department of Lothar Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 7:254-61. 2004
    The respiratory pathways of glycolysis, the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain are ubiquitous throughout nature...
  64. ncbi Expression profiling of cassava storage roots reveals an active process of glycolysis/gluconeogenesis
    Jun Yang
    Shanghai Center for Cassava Biotechnology, National Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200032, China
    J Integr Plant Biol 53:193-211. 2011
    ..Among 25 significantly changed pathways identified, glycolysis/gluconeogenesis was the most evident one...
  65. ncbi Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
    J Chen
    Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Oncogene 30:4297-306. 2011
    ..As PKM2 universally expresses in cancer cells and dictates the last rate-limiting step of glycolysis vital for cancer cell proliferation and survival, enantiomeric shikonin and alkannin may have potential in ..
  66. pmc The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
    K S Dimmer
    Physiologisches Institut der Universitat, Gmelinstr 5, D 72076 Tubingen, Germany
    Biochem J 350:219-27. 2000
    ..Similar to MCT1, monocarboxylate transport via MCT4 was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid...
  67. pmc TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization
    Wenyue Sun
    Department of Otolaryngology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
    Clin Cancer Res 16:857-66. 2010
    ..the aberrant expression of Transkelolase-like 1 (TKTL1) in head and neck squamous cell carcinoma (HNSCC) tumorigenesis and to characterize TKTL1 contribution to HNSCC tumorigenesis through aerobic glycolysis and HIF1alpha stabilization.
  68. ncbi A flux model of glycolysis and the oxidative pentosephosphate pathway in developing Brassica napus embryos
    Jorg Schwender
    Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 278:29442-53. 2003
    ..in this conversion, a quantitative metabolic flux model was developed and tested for the reaction network of glycolysis and the oxidative pentose phosphate pathway (OPPP)...
  69. ncbi Glycolysis: a bioenergetic or a survival pathway?
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Salamanca, Spain
    Trends Biochem Sci 35:145-9. 2010
    ..Neurons are unable to increase glycolysis due to the lack of activity of the glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose 2,6-..
  70. ncbi Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis
    X Liu
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    Oncogene 29:442-50. 2010
    ..The reason that cancer cells have a higher rate of aerobic glycolysis, but not oxidative phosphorylation, remains largely unclear...
  71. pmc Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    Katsumi Iizuka
    Department of Biochemistry, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Proc Natl Acad Sci U S A 101:7281-6. 2004
    ....
  72. pmc Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 27:7381-93. 2007
    ..lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, ..
  73. ncbi 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure
    Mireia Garriga-Canut
    Department of Neurology, Medical Science Center, Room 1715, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Neurosci 9:1382-7. 2006
    ..The metabolic regulation of neuronal genes by CtBP will open avenues of therapy for neurological disorders and cancer...
  74. ncbi Metabolic functions of glycosomes in trypanosomatids
    Paul A M Michels
    Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology and Laboratory of Biochemistry, Universite Catholique de Louvain, ICP TROP 74 39, Avenue Hippocrate 74, B 1200 Brussels, Belgium
    Biochim Biophys Acta 1763:1463-77. 2006
    ..The compartmentation of glycolysis in these organelles appears essential for the regulation of this process and enables the cells to overcome short ..
  75. ncbi p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
    Keiko Kawauchi
    Department of Molecular Oncology, Institute of Gerontology, Nippon Medical School, Kosugi cho 1 396, Nakahara ku, Kawasaki shi, Kanagawa 211 8533, Japan
    Nat Cell Biol 10:611-8. 2008
    Cancer cells use aerobic glycolysis preferentially for energy provision and this metabolic change is important for tumour growth...
  76. pmc Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy
    Saroj P Mathupala
    Department of Neurological Surgery and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, United States
    Semin Cancer Biol 19:17-24. 2009
    ..High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase...
  77. pmc Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays
    Jung whan Kim
    Graduate Program of Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 24:5923-36. 2004
    ..MYC overexpression enhances glycolysis without hypoxia and hence may contribute to altered tumor metabolism...
  78. pmc Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes
    Jurgen R Haanstra
    Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, NL 1081 HV, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:17718-23. 2008
    ATP generation by both glycolysis and glycerol catabolism is autocatalytic, because the first kinases of these pathways are fuelled by ATP produced downstream...
  79. ncbi PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci Signal 2:pe75. 2009
    ..This effect, which describes the propensity for cancer cells to convert glucose to lactate at a high rate, must now accommodate links among glycolysis, the tricarboxylic acid cycle, and glutamine metabolism in cancer cells.
  80. ncbi The presence of the glycolysis operon in SAR11 genomes is positively correlated with ocean productivity
    M S Schwalbach
    Oregon State University, Department of Microbiology, 220 Nash Hall, Corvallis, OR 97331, USA
    Environ Microbiol 12:490-500. 2010
    ..shunt (zwf-, pgl-), genes for the Embden-Meyerhoff-Parnas (pfk-, pyk-) and Entner-Doudoroff (eda-) pathways of glycolysis. Strain HTCC7211, isolated from an ocean gyre, was missing other glycolysis genes as well...
  81. pmc Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition
    Andrei G Vlassenko
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:17763-7. 2010
    ..we here report on regional glucose use apart from that entering oxidative phosphorylation (so-called "aerobic glycolysis")...
  82. pmc Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited
    Alexei Vazquez
    Department of Radiation Oncology, The Cancer Institute of New Jersey and UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08963, USA
    BMC Syst Biol 4:58. 2010
    Cancer cells simultaneously exhibit glycolysis with lactate secretion and mitochondrial respiration even in the presence of oxygen, a phenomenon known as the Warburg effect...
  83. ncbi p53 regulates mitochondrial respiration
    Satoaki Matoba
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 312:1650-3. 2006
    The energy that sustains cancer cells is derived preferentially from glycolysis. This metabolic change, the Warburg effect, was one of the first alterations in cancer cells recognized as conferring a survival advantage...
  84. pmc The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer
    Christoph Ruckenstuhl
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    PLoS ONE 4:e4592. 2009
    Otto Warburg observed that cancer cells are often characterized by intense glycolysis in the presence of oxygen and a concomitant decrease in mitochondrial respiration...
  85. ncbi Revving the engine: signal transduction fuels T cell activation
    Russell G Jones
    Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunity 27:173-8. 2007
    ....
  86. pmc Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library
    James C Morris
    Department of Biological Chemistry, Johns Hopkins Medical School, 725 N Wolfe Street, Baltimore, MD 21205, USA
    EMBO J 21:4429-38. 2002
    ..This switch results from silencing a hexokinase gene. The relationship between procyclin expression and glycolysis was supported by silencing other genes in the glycolytic pathway, and confirmed by observation of a similar ..
  87. pmc Berberine improves glucose metabolism through induction of glycolysis
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 294:E148-56. 2008
    ..An increase in glycolysis was observed with a rise in lactic acid production...
  88. ncbi Glycolysis as a target for the design of new anti-trypanosome drugs
    C L Verlinde
    Department of Biological Structure, Biomolecular Structure Center, University of Washington, Seattle, USA
    Drug Resist Updat 4:50-65. 2001
    b>Glycolysis is perceived as a promising target for new drugs against parasitic trypanosomatid protozoa because this pathway plays an essential role in their ATP supply...
  89. ncbi Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma
    Takashi Hamaguchi
    Department of Digestive Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Int J Oncol 33:725-31. 2008
    An increased level of glycolysis, an intracellular hallmark of neoplasms, enables cancer cells to survive under various conditions...
  90. ncbi Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions
    John Roiniotis
    Department of Medicine, Arthritis and Inflammation Research Centre and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 182:7974-81. 2009
    ..as reported for macrophage cell lines, while others survive better as they shift their metabolism to anaerobic glycolysis. It was found here that hypoxia prolongs the survival of murine bone marrow-derived macrophages, either in the ..
  91. pmc Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    Ryan D Michalek
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 186:3299-303. 2011
    ..Treg, in contrast, expressed low levels of Glut1 and had high lipid oxidation rates. Consistent with glycolysis and lipid oxidation promoting Teff and Treg, respectively, Teff were selectively increased in Glut1 transgenic ..
  92. pmc Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers
    Agnieszka K Witkiewicz
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:1108-17. 2012
    We have recently proposed a new model of cancer metabolism to explain the role of aerobic glycolysis and L-lactate production in fueling tumor growth and metastasis...
  93. ncbi The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
    Gloria Bonuccelli
    Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 9:1960-71. 2010
    ..fibroblasts indicates that these cells upregulate the expression of glycolytic enzymes, a hallmark of aerobic glycolysis (the Warburg effect)...
  94. ncbi Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
    L A Pradelli
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, équipe 3 AVENIR, Nice, France
    Oncogene 29:1641-52. 2010
    Most cancer cells exhibit increased glycolysis for generation of their energy supply. This specificity could be used to preferentially kill these cells...
  95. ncbi Cancer metabolism: the Warburg effect today
    Leonardo M R Ferreira
    Departamento de Ciências da Vida, Faculdade de Ciencias e Tecnologia, Universidade de Coimbra, Rua dos Estudos, 3001 401 Coimbra, Portugal
    Exp Mol Pathol 89:372-80. 2010
    ..Considerable work has been done since then, deepening our understanding of the process, with consequences for diagnosis and therapy. This review presents facts and perspectives on the Warburg effect for the 21st century...
  96. pmc A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
    Marco Demaria
    Molecular Biotechnology Center and Department of Genetics, Biology and Biochemistry, University of Turin, Via Nizza 52, 10126 Turin, Italy
    Aging (Albany NY) 2:823-42. 2010
    ..We show here that constitutively active STAT3 acts as a master regulator of cell metabolism, inducing aerobic glycolysis and down-regulating mitochondrial activity both in primary fibroblasts and in STAT3-dependent tumour cell lines...
  97. ncbi The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
    Wei Shao
    Department of Biochemistry, Division of Critical Care, Centre for the Study of Host Resistance, McGill University, Montreal, Quebec, Canada
    J Biol Chem 282:36321-9. 2007
    ..A series of unexpected proteins along the glycolysis pathway were also identified, including aldolase, triose-phosphate isomerase, glyceraldehyde-3-phosphate ..
  98. ncbi HIF-1 mediates the Warburg effect in clear cell renal carcinoma
    Gregg L Semenza
    Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology, and McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Bioenerg Biomembr 39:231-4. 2007
    ..to a HIF-1-dependent reprogramming of glucose and energy metabolism that includes increased glucose uptake, glycolysis, and lactate production accompanied by a reciprocal decrease in respiration...
  99. ncbi Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells
    Olivier Feron
    Unit of Pharmacology and Therapeutics, Universite Catholique de Louvain, Brussels, Belgium
    Radiother Oncol 92:329-33. 2009
    ..Hypoxia and oncogenic mutations drive glycolysis, with the pyruvate to lactate conversion being promoted by increased expression of lactate dehydrogenase A and ..
  100. ncbi Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
    Huasheng Lu
    Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 280:41928-39. 2005
    ..Since HIF-1 itself promotes glycolytic metabolism, enhancement of HIF-1 by glucose metabolites may constitute a novel feed-forward signaling mechanism involved in malignant progression...
  101. ncbi Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia
    Keith A Webster
    Department of Molecular and Cellular Pharmacology, University of Miami Medical Center, Miami, FL 33136, USA
    J Exp Biol 206:2911-22. 2003
    ..falls below a critical mark metabolic switches turn off mitochondrial electron transport and activate anaerobic glycolysis. Without this switch cells would suffer an immediate energy deficit and death at low P(O)...

Research Grants30

  1. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..To compensate for energy deficiency, glucose uptake and glycolysis are elevated...
  2. Metabolic mechanisms of antiestrogen resistance in breast cancer
    UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2013
    ..stroma with increased reactive oxygen species (ROS), low oxidative phosphorylation metabolism (OXPHOS) and high glycolysis is found in aggressive breast cancers...
  3. Pax8-PPARgamma regulation of transcription and metabolism in thyroid cancer
    RONALD JAY KOENIG; Fiscal Year: 2013
    ..A Seahorse XF24 bioanalyzer will be used to evaluate how much energy metabolism is via glycolysis versus the TCA cycle. The use of glucose versus fatty acids as energy sources will be evaluated...
  4. Intermediary Metabolism, Histone Acetylation, and Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2013
    ..The central hypothesis of this proposal, based on our preliminary data, is that regulation of glucose uptake, glycolysis, and ACC affect homeostasis of acetyl-CoA and consequently histone acetylation and transcriptional regulation...
  5. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..for diabetes complications, causes an increase in cytosolic ph and related activation of the upper part of glycolysis. The overall hypothesis of this proposal is that NHE-1 plays an important role in PDN, because NHE-1-driven ..
  6. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    ..data suggesting that both dietary and genetic risk for intestinal cancer cause an early shift towards glycolysis in cells of the normal appearing mucosa, specifically in the progenitor/proliferating cell compartment, long ..
  7. Nitric Oxide in Pulmonary Hypertension
    Serpil C Erzurum; Fiscal Year: 2013
    ..NO, the cells have reduced mitochondria numbers &respiration, which is accompanied by ~3-fold increase in glycolysis for energy production...
  8. Metabolic Dysfunction and Neuroprotection after Pediatric Head Injury
    Susanna Scafidi; Fiscal Year: 2013
    ..failure post TBI is due to specific mitochondrial enzymes impairment, which precludes pyruvate, generated via glycolysis, from being utilized in the mitochondria for energy production...
  9. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
    ..G6PD is the first and rate-limiting enzyme of the pentose phosphate pathway, is reversibly linked to glycolysis and mitochondrial respiration, and is the principal cytosolic source of NADPH, a reducing equivalent that is ..
  10. Astrocytic Ca2+ Signaling in the Ischemic Penumbra
    Maiken Nedergaard; Fiscal Year: 2011
    ..Specific points: Reviewer 2 was unconvinced by the rationale for correlating rates of glycolysis with ATPrelease. We have removed this aim...
  11. Protein Modifications and Unfolded Protein Response in Diabetic Embryopathy
    Zhiyong Zhao; Fiscal Year: 2013
    ..Maternal hyperglycemia disturbs glucose metabolism (glycolysis) in the embryo, augmenting the hexosamine biosynthetic pathway (HBP) to produce high levels of uridine ..
  12. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..a unique shift in cell metabolism from oxidative phosphorylation, which efficiently produces energy, to aerobic glycolysis, which generates bio-precursors (such as lipids, amino acids, and nucleotides) required to fuel cell division...
  13. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    ..glucose such that when oxidized, acetyl-CoA units enter the Krebs-TCA cycle at the level of citrate bypassing glycolysis (the step after pyruvate dehydrogenase complex which is often a metabolic block following oxidative stress) and ..
  14. Interventions Against the Molecular Etiology of BMPR2-induced PAH
    James D West; Fiscal Year: 2013
    ..increase in peroxide formation, and RNA expression changes suggestive of increased ROS and a shift to aerobic glycolysis and glutaminolysis...
  15. Role of Tumor and Stromal Cell Metabolism in Stress Adaptation and Progression
    EILEEN contact WHITE; Fiscal Year: 2010
    ..Causation The molecular events that covert normal cells into tumor cells alter cellular metabolism to aerobic glycolysis, which favors macromolecular synthesis at the expense of efficient ATP production...
  16. Characterizaton of Motility Factor Receptor
    Avraham Raz; Fiscal Year: 2012
    ..Phosphoglucose isomerase (PGI) is a ubiquitous housekeeping cytosolic enzyme that plays a key role in both glycolysis and gluconeogenesis pathways. Upon secretion PGI acts as a potent mitogen/cytokine e.g...
  17. Glucose energy metabolism in the growth and survival of B lymphocytes
    THOMAS CRANE CHILES; Fiscal Year: 2010
    ..We have also uncovered a novel pathway that links Fc?RIIB engagement to decreased glycolysis, a response remarkably similar to decreased glycolytic flux observed upon removal of growth factors from ..
  18. Seahorse XF96 Extracellular Flux Analyzer
    Enrique Saez; Fiscal Year: 2013
    ..Flux Analyzer provides an unprecedented, thorough and fast assessment of oxidative phosphorylation, glycolysis, nutrient utilization, fatty acid oxidation, coupled vs...
  19. Energy Restrction and Mammary Cancer
    Henry J Thompson; Fiscal Year: 2013
    ..The mechanisms that will be investigated include inhibition of autophagy, blocking the switch to aerobic glycolysis, and inhibition of sirtuin-mediated deacetylation...
  20. 5500 Q-Trap Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2010
    ..These include the proteasome complex in activated neutrophils, the enzymes in glycolysis and energy generating mitochondrial pathways, and the lens crystallins in aging...
  21. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..NO, the cells have reduced mitochondria numbers &respiration, which is accompanied by ~3-fold increase in glycolysis for energy production...
  22. SKELETAL MUSCLE BEHAVIOR IN HEART FAILURE
    John Wilson; Fiscal Year: 1990
    ..that this exercise intolerance is caused by underperfusion of skeletal muscle with resultant early muscle glycolysis and that the muscle underperfusion is due at least in part to impaired muscle arteriolar dilation...
  23. Stereochemistry of Elimination and Proton Transfer
    JERRY MOHRIG; Fiscal Year: 2002
    ..They are important from fatty acid metabolism to glycolysis and the citric acid cycle, from terpene biosynthesis to the shikimic acid pathway...
  24. Genotype and Metabolic Phenotype in Glioblastoma
    Elizabeth A Maher; Fiscal Year: 2010
    ..glioblastoma - increased glucose uptake - is feeding one or some combination of three pathways: excess anaerobic glycolysis to lactate, excess aerobic glycolysis to pyruvate followed by oxidation in the citric acid cycle, or excess flux ..
  25. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2005
    ..muscle cells and cardiac myocytes from hypoxia-induced apoptosis and determined that such protection required glycolysis. We also have shown that glucose transporter expression and glucose metabolism prevent activation of the ..
  26. Glycolysis and Glutamate Storage into Synaptic Vesicles
    Tetsufumi Ueda; Fiscal Year: 2010
    ..It is hoped that knowledge gained from this research will be of use in creating a new approach to treatment of certain neurological and mental disorders. ..
  27. DYSFUNCTION OF POSTISCHEMIC MYOCARDIUM
    Lewis Becker; Fiscal Year: 2000
    ..This hypothesis follows from our previous results which demonstrate: (a) glycolysis must be intact during early reperfusion to prevent a marked rise in myocardial [Ca2+]i, (2) all of the ..
  28. HORMONAL CONTROL OF HEPATIC GLUCONEOGENESIS/GLYCOLYSIS
    Alex Lange; Fiscal Year: 2005
    ..abstract_text> ..
  29. Therapy for Liver Cancer by Targeting Energy Metabolism
    Jean Francois Geschwind; Fiscal Year: 2007
    ..Work performed in our laboratory has determined the importance of glycolysis to generate energy for rapidly growing cancer cells...
  30. Effects of Insulin on VSM Migration
    Andrew Kahn; Fiscal Year: 2004
    ..2) To achieve this, insulin stimulates aerobic glycolysis, thereby raising the redox potential which stimulates cyclic GMP production induced by the NO already present in ..