citric acid cycle

Summary

Summary: A series of oxidative reactions in the breakdown of acetyl units derived from GLUCOSE; FATTY ACIDS; or AMINO ACIDS by means of tricarboxylic acid intermediates. The end products are CARBON DIOXIDE, water, and energy in the form of phosphate bonds.

Top Publications

  1. ncbi Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
    Alisdair R Fernie
    Department of Lothar Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 7:254-61. 2004
  2. ncbi Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
    Weihai He
    Tularik Inc, 1120 Veterans Boulevard, South San Francisco, California 94080, USA
    Nature 429:188-93. 2004
  3. pmc Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line
    Hyuntae Yoo
    Department of Chemistry and Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Biol Chem 283:20621-7. 2008
  4. pmc An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)
    Jennifer L Reed
    Department of Bioengineering, University of California, San Diego, Gilman Drive, La Jolla, CA 92092, USA
    Genome Biol 4:R54. 2003
  5. pmc Metabolic network fluxes in heterotrophic Arabidopsis cells: stability of the flux distribution under different oxygenation conditions
    Thomas C R Williams
    Department of Plant Sciences, University of Oxford, Oxford, United Kingdom
    Plant Physiol 148:704-18. 2008
  6. pmc Evidence for autotrophic CO2 fixation via the reductive tricarboxylic acid cycle by members of the epsilon subdivision of proteobacteria
    Michael Hügler
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    J Bacteriol 187:3020-7. 2005
  7. ncbi Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
    Peppi Koivunen
    Collagen Research Unit, Biocenter Oulu, Departments of Medical Biochemistry and Molecular Biology and Neurology, University of Oulu, FIN 90014 Oulu, Finland
    J Biol Chem 282:4524-32. 2007
  8. pmc Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth
    Eleanor C Saunders
    Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Biol Chem 286:27706-17. 2011
  9. pmc The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates
    Felix Knauf
    Franz Volhard Clinic at the Max Delbruck Center, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, D 13125 Berlin, Germany
    Biochem J 397:25-9. 2006
  10. ncbi Not just a circle: flux modes in the plant TCA cycle
    Lee J Sweetlove
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX13RB, UK
    Trends Plant Sci 15:462-70. 2010

Research Grants

Detail Information

Publications290 found, 100 shown here

  1. ncbi Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
    Alisdair R Fernie
    Department of Lothar Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 7:254-61. 2004
    ..Recently, a wide range of molecular and biochemical strategies have been adopted to elucidate the functional significance of these interactions...
  2. ncbi Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
    Weihai He
    Tularik Inc, 1120 Veterans Boulevard, South San Francisco, California 94080, USA
    Nature 429:188-93. 2004
    The citric acid cycle is central to the regulation of energy homeostasis and cell metabolism. Mutations in enzymes that catalyse steps in the citric acid cycle result in human diseases with various clinical presentations...
  3. pmc Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line
    Hyuntae Yoo
    Department of Chemistry and Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Biol Chem 283:20621-7. 2008
    ..for fatty acid synthesis from glutamine may follow either of two distinct pathways after it enters the citric acid cycle. The glutaminolysis pathway follows the citric acid cycle, whereas the reductive carboxylation pathway ..
  4. pmc An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)
    Jennifer L Reed
    Department of Bioengineering, University of California, San Diego, Gilman Drive, La Jolla, CA 92092, USA
    Genome Biol 4:R54. 2003
    ..The most comprehensive E. coli model to date (E. coli iJE660a GSM) accounts for 660 genes and includes 627 unique biochemical reactions...
  5. pmc Metabolic network fluxes in heterotrophic Arabidopsis cells: stability of the flux distribution under different oxygenation conditions
    Thomas C R Williams
    Department of Plant Sciences, University of Oxford, Oxford, United Kingdom
    Plant Physiol 148:704-18. 2008
    ....
  6. pmc Evidence for autotrophic CO2 fixation via the reductive tricarboxylic acid cycle by members of the epsilon subdivision of proteobacteria
    Michael Hügler
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    J Bacteriol 187:3020-7. 2005
    ....
  7. ncbi Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
    Peppi Koivunen
    Collagen Research Unit, Biocenter Oulu, Departments of Medical Biochemistry and Molecular Biology and Neurology, University of Oulu, FIN 90014 Oulu, Finland
    J Biol Chem 282:4524-32. 2007
    ..We have studied possible links between metabolic pathways and HIF hydroxylases by analyzing the abilities of citric acid cycle intermediates to inhibit purified human HIF-P4Hs and FIH...
  8. pmc Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth
    Eleanor C Saunders
    Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Biol Chem 286:27706-17. 2011
    ....
  9. pmc The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates
    Felix Knauf
    Franz Volhard Clinic at the Max Delbruck Center, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, D 13125 Berlin, Germany
    Biochem J 397:25-9. 2006
    ..The effect of decreasing INDY activity, as in the long-lived Indy mutants, may be to alter energy metabolism in a manner that favours lifespan extension...
  10. ncbi Not just a circle: flux modes in the plant TCA cycle
    Lee J Sweetlove
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX13RB, UK
    Trends Plant Sci 15:462-70. 2010
    ..Thus, alternative, non-cyclic flux modes occur in leaves in the light, in some developing oilseeds, and under specific physiological circumstances such as anoxia...
  11. pmc Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum
    Daniel Amador-Noguez
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    J Bacteriol 192:4452-61. 2010
    ....
  12. pmc Carbon flow of heliobacteria is related more to clostridia than to the green sulfur bacteria
    Kuo Hsiang Tang
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    J Biol Chem 285:35104-12. 2010
    ..Moreover, in contrast to (Si)-citrate synthase, (Re)-citrate synthase produces a different isomer of 2-fluorocitrate that is not expected to inhibit the activity of aconitase...
  13. ncbi Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma
    Emily H Smith
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA
    Hum Mol Genet 16:3136-48. 2007
    ..Our results suggest that any alphaKG-dependent enzyme is a potential target of accumulated succinate in oncogenesis. The possible role that inhibition of these enzymes by succinate may have in oncogenesis is discussed...
  14. ncbi S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate
    Nathan L Alderson
    Department of Chemistry and Biochemistry, University of South Carolina, USA
    Arch Biochem Biophys 450:1-8. 2006
    ..These observations identify fumarate as an endogenous electrophile and suggest a role for fumarate in regulation of metabolism...
  15. ncbi Physiological proteomics of the uncultured endosymbiont of Riftia pachyptila
    Stephanie Markert
    Institute of Marine Biotechnology, Walther Rathenau Strasse 49, D 17489 Greifswald, Germany
    Science 315:247-50. 2007
    ..Unexpectedly, the symbiont uses the reductive tricarboxylic acid cycle in addition to the previously identified Calvin cycle for CO2 fixation...
  16. ncbi Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
    P J Pollard
    Molecular and Population Genetics Laboratory, London WC2A 3PX, UK
    Hum Mol Genet 14:2231-9. 2005
    ..The basic mechanism of tumorigenesis in HPGL and HLRCC is likely to be pseudo-hypoxic drive, just as it is in von Hippel-Lindau syndrome...
  17. ncbi Cells silenced for SDHB expression display characteristic features of the tumor phenotype
    Ana M Cervera
    Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
    Cancer Res 68:4058-67. 2008
    ....
  18. ncbi Inborn errors of complex II--unusual human mitochondrial diseases
    Pierre Rustin
    Unité de Recherches sur les Handicaps Génétiques de l Enfant INSERM U 393, Tour Lavoisier, Hopital Necker Enfants Malades, 149, rue de Sevres, F 75743 Cedex 15, Paris, France
    Biochim Biophys Acta 1553:117-22. 2002
    ....
  19. ncbi Respiratory and TCA cycle activities affect S. cerevisiae lifespan, response to caloric restriction and mtDNA stability
    Erich B Tahara
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Cidade Universitaria, Av Prof Lineu Prestes, 748 São Paulo, SP, Brazil 05508 000
    J Bioenerg Biomembr 43:483-91. 2011
    ..Altogether, our data indicate that respiratory integrity is required for lifespan extension by CR and that mtDNA stability is regulated by nucleoid proteins in a glucose-sensitive manner...
  20. pmc Gene regulatory changes in yeast during life extension by nutrient limitation
    Jinqing Wang
    Department of Medicine and the Tulane Center for Aging, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Exp Gerontol 45:621-31. 2010
    ..These gene regulatory events portend an increase in the generation of biosynthetic intermediates necessary for the production of daughter cells, which is the measure of yeast replicative life span...
  21. pmc Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii
    James I Macrae
    Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, VIC 3010, Australia
    Cell Host Microbe 12:682-92. 2012
    ..Thus, T. gondii tachyzoites have metabolic flexibility that likely allows the parasite to infect diverse cell types...
  22. ncbi Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii
    Tobias Fleige
    Institute of Medical Microbiology, University of Gottingen, Kreuzbergring 57, Gottingen, Germany
    Int J Parasitol 38:1121-32. 2008
    ..The lack of a more severe phenotype suggests that a functional TCA cycle is not essential for T. gondii replication and for maintenance of the mitochondrial membrane potential...
  23. pmc Metabolic fate of fumarate, a side product of the purine salvage pathway in the intraerythrocytic stages of Plasmodium falciparum
    Vinay Bulusu
    Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560 064, Karnataka, India
    J Biol Chem 286:9236-45. 2011
    ..This study, therefore, provides a biosynthetic function for fumarate hydratase, malate quinone oxidoreductase, and aspartate aminotransferase of P. falciparum...
  24. ncbi The metabolic architecture of plant cells. Stability of central metabolism and flexibility of anabolic pathways during the growth cycle of tomato cells
    Denis Rontein
    UMR 619, Biotechnologie et Physiologie Végétales, Institut de Biologie Végétale et Moléculaire, Institut National de la Recherche Agronomique, Bordeaux, BP 81, Villenave d Ornon 33883 cedex, France
    J Biol Chem 277:43948-60. 2002
    ..We conclude that anabolic fluxes constitute the flexible part of plant cell metabolism that can fluctuate in relation to cell demands for growth...
  25. ncbi Essentiality of mitochondrial oxidative metabolism for photosynthesis: optimization of carbon assimilation and protection against photoinhibition
    K Padmasree
    Department of Plant Sciences, School of Life Sciences, University of Hyderabad, India
    Crit Rev Biochem Mol Biol 37:71-119. 2002
    ..The uses of techniques such as on-line mass spectrometric measurement, novel mutants/transgenics, and variability in metabolism by growth conditions hold a high promise to help the plant biologist to understand this..
  26. pmc Evidence of chemolithoautotrophy in the bacterial community associated with Alvinella pompejana, a hydrothermal vent polychaete
    Barbara J Campbell
    College of Marine Studies, University of Delaware, Lewes, Delaware 19958, USA
    Appl Environ Microbiol 69:5070-8. 2003
    ..Our results suggest that members of both the episymbiont and the surrounding free-living communities display a chemolithoautotrophic form of growth and therefore contribute fixed carbon to other organisms in the vent community...
  27. pmc Nonlinear dependency of intracellular fluxes on growth rate in miniaturized continuous cultures of Escherichia coli
    Annik Nanchen
    Institute of Molecular Systems Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Appl Environ Microbiol 72:1164-72. 2006
    ....
  28. ncbi Interaction between photosynthesis and respiration in illuminated leaves
    Ko Noguchi
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mitochondrion 8:87-99. 2008
    ..Based on recent advances in our understanding about the metabolic interaction between chloroplasts and mitochondria, we discuss the importance of the respiratory chain for stabilizing the photosynthetic system...
  29. ncbi Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 418:344-8. 2002
    ..We discuss how this metabolic strategy may apply to CR in animals...
  30. pmc Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans
    You Jun Fei
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem J 379:191-8. 2004
    ..or in Xenopus oocytes, the cloned ceNAC-2 mediates the Na+-coupled transport of various intermediates of the citric acid cycle. However, it transports the tricarboxylate citrate more efficiently than dicarboxylates such as succinate, a ..
  31. ncbi Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
    Jean Pierre Bayley
    Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Building 2, Leiden, The Netherlands
    Curr Opin Genet Dev 20:324-9. 2010
    ..Here we discuss these diverse hypotheses and highlight very recent findings on the possible effects of IDH gene mutations...
  32. pmc Tricarboxylic acid cycle-dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis
    Marat R Sadykov
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    J Bacteriol 190:7621-32. 2008
    ..In addition, these data lead us to propose that the TCA cycle acts as a signal transduction pathway to translate external environmental cues into intracellular metabolic signals that modulate the activity of transcriptional regulators...
  33. ncbi Autotrophic CO2 fixation via the reductive tricarboxylic acid cycle in different lineages within the phylum Aquificae: evidence for two ways of citrate cleavage
    Michael Hügler
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Environ Microbiol 9:81-92. 2007
    ..Thus, these findings substantiate the hypothesis that autotrophic carbon fixation through the reductive TCA cycle is widespread and contributes significantly to biomass production particularly in hydrothermal habitats...
  34. pmc Glutamine metabolism is essential for human cytomegalovirus infection
    Jeremy W Chambers
    Department of Cancer Biology, 314 Biomedical Research Building, 421 Curie Blvd, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
    J Virol 84:1867-73. 2010
    ....
  35. pmc Universality in intermediary metabolism
    Eric Smith
    Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA
    Proc Natl Acad Sci U S A 101:13168-73. 2004
    ..The ability to enhance the rate of core reactions creates an energetic basis for selection of subsequent layers of biological complexity...
  36. ncbi Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells
    Qiuwei Xu
    Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA
    J Biomol NMR 49:207-19. 2011
    ..The close coupling of the TCA cycle to the electron transfer chain (ETC) in OXPHOS enables specific diagnoses of inhibition to ETC complexes by discrete biochemical changes in the TCA cycle...
  37. pmc Unraveling condition-dependent networks of transcription factors that control metabolic pathway activity in yeast
    Sarah Maria Fendt
    Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
    Mol Syst Biol 6:432. 2010
    ....
  38. ncbi Energy metabolism in astrocytes and neurons treated with manganese: relation among cell-specific energy failure, glucose metabolism, and intercellular trafficking using multinuclear NMR-spectroscopic analysis
    Claudia Zwingmann
    Department of Medicine, Hôpital Saint Luc CHUM, University of Montreal, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 23:756-71. 2003
    ..The results suggest that, concomitant to impaired neuronal glucose oxidation, changes in astrocytic metabolism may cause a loss of intercellular homeostatic equilibrium, contributing to neuronal dysfunction in manganese neurotoxicity...
  39. pmc Reconstruction of the central carbohydrate metabolism of Thermoproteus tenax by use of genomic and biochemical data
    Bettina Siebers
    Department of Microbiology, Universitat Duisburg Essen, 45117 Essen, Germany
    J Bacteriol 186:2179-94. 2004
    ..tenax. Most genes involved in the reversible citric acid cycle were identified, suggesting the presence of a functional oxidative cycle under heterotrophic growth ..
  40. ncbi Control of key metabolic intersections in Bacillus subtilis
    Abraham L Sonenshein
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Nat Rev Microbiol 5:917-27. 2007
    ..Here, the latest knowledge on the control of these key intersections in B. subtilis is reviewed...
  41. ncbi Simultaneous determination of anionic intermediates for Bacillus subtilis metabolic pathways by capillary electrophoresis electrospray ionization mass spectrometry
    Tomoyoshi Soga
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan
    Anal Chem 74:2233-9. 2002
    ..This method was applied to the comprehensive analysis of metabolic intermediates extracted from Bacillus subtilis, and 27 anionic metabolites could be directly detected and quantified...
  42. ncbi Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice
    J L Wu
    Guangdong Institute of Microbiology, Guangzhou, China
    Physiol Res 56:213-20. 2007
    ..These enzymatic activities may be useful indicators for evaluating changes affecting the malate-aspartate shuttle and energy metabolism in the liver of mice...
  43. ncbi Tricarboxylic acid cycle enzymes following thiamine deficiency
    Parvesh Bubber
    Department of Neurology and Neuroscience, Burke Medical Research Institute, Weill Medical College, Cornell University, 785 Mamaroneck Avenue, White Plains, NY 10605, USA
    Neurochem Int 45:1021-8. 2004
    ..The diminished activities of multiple TCA cycle enzymes may be important in our understanding of how metabolic lesions alter brain function in neurodegenerative disorders...
  44. pmc Mild reductions in cytosolic NADP-dependent isocitrate dehydrogenase activity result in lower amino acid contents and pigmentation without impacting growth
    Ronan Sulpice
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam Golm, Germany
    Amino Acids 39:1055-66. 2010
    ..These data are discussed within the context of current models for the role of the various isoforms of isocitrate dehydrogenase within plant amino acid metabolism...
  45. ncbi Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia
    Blandine Comte
    Department of Nutrition, University of Montreal, Quebec H3C 3J7, Canada
    Am J Physiol Heart Circ Physiol 283:H1505-14. 2002
    ..We tested the hypothesis that in the heart, NADP(+)-ICDH operates in the reverse direction of the citric acid cycle (CAC) and thereby may contribute to the fine regulation of CAC activity (Sazanov and Jackson, FEBS Lett 344: ..
  46. ncbi Glutamate decreases pyruvate carboxylase activity and spares glucose as energy substrate in cultured cerebellar astrocytes
    H Qu
    Department of Clinical Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Olav Kyrresgt. 3, N-7489 Trondheim, Norway
    J Neurosci Res 66:1127-32. 2001
    ..It could be shown that glucose is a better substrate for energy production than glutamate; it is, however, less efficient in labeling amino acids than glutamate in cerebellar astrocytes...
  47. ncbi SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling
    William G Kaelin
    Howard Hughes Medical Institute, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Cell 16:180-2. 2009
    ..Moreover, they detected SDH5 mutations in a large kindred with familial paraganglioma...
  48. pmc Abundance of reverse tricarboxylic acid cycle genes in free-living microorganisms at deep-sea hydrothermal vents
    Barbara J Campbell
    College of Marine Studies, University of Delaware, 700 Pilottown Rd, Lewes, DE 19958, USA
    Appl Environ Microbiol 70:6282-9. 2004
    ..Therefore, the reverse tricarboxylic acid cycle may be a major autotrophic pathway in these environments and significantly contribute to global autotrophic processes...
  49. ncbi Inborn errors of the Krebs cycle: a group of unusual mitochondrial diseases in human
    P Rustin
    Unite de Recherches sur les Handicaps Genetiques de l Enfant, INSERM U 393, Hopital des Enfants Malades, Paris, France
    Biochim Biophys Acta 1361:185-97. 1997
    ....
  50. pmc Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans
    Yiyuan Yuan
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 287:31414-26. 2012
    ..We conclude that an increase, not a decrease in fuel consumption, via an accelerated oxidation of fuels in the TCA cycle is involved in life span regulation; this mechanism may be conserved across phylogeny...
  51. ncbi The visualization by affinity electrophoresis of a specific association between the consecutive citric acid cycle enzymes fumarase and malate dehydrogenase
    S Beeckmans
    Laboratorium voor Chemie der Proteinen, Vrije Universiteit Brussel, Belgium
    Eur J Biochem 183:449-54. 1989
    Evidence is growing that the citric acid cycle, like many other metabolic pathways, might exist in vivo as a more or less tightly organized multi-enzyme cluster. The term 'metabolon' [Robinson, J. B. & Srere, P. A. (1985) J. Biol...
  52. ncbi Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia
    A Rotig
    INSERM U393, Département de génétique, Hopital Necker Enfants Malades, Paris, France
    Nat Genet 17:215-7. 1997
    ..Mutated frataxin triggers aconitase and mitochondrial Fe-S respiratory enzyme deficiency in FRDA, which should therefore be regarded as a mitochondrial disorder...
  53. pmc Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice
    Connie S Yarian
    Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Mech Ageing Dev 127:79-84. 2006
    The activities of the citric acid cycle enzymes were determined in mitochondria isolated from kidneys of relatively young, middle age, and old mice. Aconitase exhibited the most significant decrease in activity with age...
  54. pmc Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates
    J M Weinberg
    Division of Nephrology, Department of Internal Medicine, University of Michigan and Veteran s Administration Medical Center, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 97:2826-31. 2000
    ..The lesion can be prevented or reversed by citric acid cycle metabolites that anaerobically generate ATP by intramitochondrial substrate-level phosphorylation and ..
  55. ncbi Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo
    Albert P Chen
    GE Healthcare, Toronto, ON, Canada
    NMR Biomed 25:305-11. 2012
    ....
  56. pmc The acetate switch
    Alan J Wolfe
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Microbiol Mol Biol Rev 69:12-50. 2005
    ..Next, the way in which cells regulate AMP-ACS activity through reversible acetylation is described. Finally, the "acetate switch" as it exists in selected eubacteria, archaea, and eukaryotes, including humans, is described...
  57. pmc Mutants of Saccharomyces cerevisiae with defects in acetate metabolism: isolation and characterization of Acn- mutants
    M T McCammon
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Genetics 144:57-69. 1996
    ..In summary, this analysis has identified at least 22 and as many as 41 different genes involved in acetate metabolism...
  58. ncbi Futile cycling of lactate through the plasma membrane of C6 glioma cells as detected by (13C, 2H) NMR
    Tiago B Rodrigues
    Laboratory for Imaging and Spectroscopy by Magnetic Resonance, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, c Arturo Duperier 4, E 28029 Madrid, Spain
    J Neurosci Res 79:119-27. 2005
    ....
  59. ncbi The key role of anaplerosis and cataplerosis for citric acid cycle function
    Oliver E Owen
    Department of Pediatrics, Case Western Reserve University School of Medicine, Robert Schwartz M D Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, OH 44109, USA
    J Biol Chem 277:30409-12. 2002
  60. ncbi Succinate synthesis and excretion by Penicillium simplicissimum under aerobic and anaerobic conditions
    Martin Gallmetzer
    Institute of Microbiology, Technikerstrasse 25, 6020 Innsbruck, Austria
    FEMS Microbiol Lett 210:221-5. 2002
    ..Succinate is then excreted because the oxidative part of the tricarboxylic acid cycle is inactive. A possible role of succinate synthesis in the regeneration of NAD ('fumarate respiration') is discussed...
  61. ncbi Resistance to vanadium in Pseudomonas fluorescens ATCC 17400 caused by mutations in TCA cycle enzymes
    Sarah Denayer
    Laboratory of Microbial Interactions, Department of Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium
    FEMS Microbiol Lett 264:59-64. 2006
    ..A nonpolar idh mutant was obtained, which showed the same level of resistance against vanadium as the original transposon mutant...
  62. ncbi Non-invasive measurements of myocardial carbon metabolism using in vivo 13C NMR spectroscopy
    Andre Ziegler
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Switzerland
    NMR Biomed 15:222-34. 2002
    ..In conclusion, it is demonstrated that 13C NMR spectroscopy of the heart in intact rats is feasible and provides new quantitative insight into myocardial substrate uptake, preference and metabolism in vivo...
  63. ncbi Autotrophic carbon dioxide fixation in Acidianus brierleyi
    M Ishii
    Department of Biotechnology, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113, Japan
    Arch Microbiol 166:368-71. 1996
    ..brierleyi was growing autotrophically. We conclude that a modified 3-hydroxypropionate pathway operates in A. brierleyi...
  64. ncbi Comparison of metabolic flux distributions for MDCK cell growth in glutamine- and pyruvate-containing media
    Yury Sidorenko
    Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, Magdeburg, Germany
    Biotechnol Prog 24:311-20. 2008
    ..Thus, the switch from glutamine-containing to glutamine-free medium with pyruvate provided a series of benefits without dramatic changes of cellular metabolism...
  65. ncbi In vitro evidence that D-serine disturbs the citric acid cycle through inhibition of citrate synthase activity in rat cerebral cortex
    Angela Zanatta
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos No 2600 Anexo, Porto Alegre, RS, Brazil
    Brain Res 1298:186-93. 2009
    ..from glucose and acetate, glucose uptake and the activities of the respiratory chain complexes I-IV, of the citric acid cycle enzymes citrate synthase, aconitase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate ..
  66. ncbi Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
    Kirsty S Hewitson
    Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom
    J Biol Chem 282:3293-301. 2007
    ....
  67. pmc Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    Ralph J DeBerardinis
    Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Room 450, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 104:19345-50. 2007
    ..Rather, glutamine metabolism provides a carbon source that facilitates the cell's ability to use glucose-derived carbon and TCA cycle intermediates as biosynthetic precursors...
  68. pmc Overflow metabolism in Escherichia coli during steady-state growth: transcriptional regulation and effect of the redox ratio
    G N Vemuri
    Center for Molecular BioEngineering, Driftmier Engineering, University of Georgia, Athens, GA 30602, USA
    Appl Environ Microbiol 72:3653-61. 2006
    ..The results provide a basis for studying new regulatory mechanisms prevalent at reduced NADH/NAD ratios, as well as for designing more efficient bioprocesses...
  69. pmc Characterization of the central metabolic pathways in Thermoanaerobacter sp. strain X514 via isotopomer-assisted metabolite analysis
    Xueyang Feng
    Department of Energy, Environmental and Chemical Engineering, Washington University, St Louis, MO 63130, USA
    Appl Environ Microbiol 75:5001-8. 2009
    ..This study demonstrates the merits of combining (13)C-assisted metabolite analysis, enzyme assays, and metabolite detection not only to examine genome sequence annotations but also to discover novel enzyme activities...
  70. pmc Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification
    Tuty Asmawaty Abdul Kadir
    Dept of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka 820 8502, Japan
    Microb Cell Fact 9:88. 2010
    ....
  71. ncbi New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle
    Susanne W H van Weelden
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands
    J Biol Chem 280:12451-60. 2005
    ..We also demonstrate that the subsequent enzymes of the Krebs cycle, succinate dehydrogenase and fumarase, are most likely used for conversion of succinate into malate, which can then be used in gluconeogenesis...
  72. ncbi SAGE surveys C. elegans carbohydrate metabolism: evidence for an anaerobic shift in the long-lived dauer larva
    Suzan J Holt
    Division of Biological Sciences and Molecular Biology Program, 311 Tucker Hall, University of Missouri, Columbia, MO 65211, USA
    Mech Ageing Dev 124:779-800. 2003
    ..Generation of nutritive fermentation byproducts and the moderation of oxidative damage are potential benefits of a hypoxic dauer interior...
  73. pmc Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression
    Marie Laure Rosso
    Inserm U801, Lille, F 59019, université Lille II, faculté de médecine Henri Warembourg, Lille, France
    BMC Microbiol 8:211. 2008
    ..However, in immunocompromised patients, the microorganism may disseminate from the digestive tract and thus cause a systemic infection with septicemia...
  74. pmc Mild reductions in mitochondrial NAD-dependent isocitrate dehydrogenase activity result in altered nitrate assimilation and pigmentation but do not impact growth
    Agata Sienkiewicz-Porzucek
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam Golm, Germany
    Mol Plant 3:156-73. 2010
    ....
  75. pmc Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions
    Maciek R Antoniewicz
    Department of Chemical Engineering, Bioinformatics and Metabolic Engineering Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Metab Eng 9:68-86. 2007
    ..For example, analysis of the gluconeogenesis pathway with (2)H, (13)C, and (18)O tracers requires only 354 EMUs, compared to more than two million isotopomers...
  76. pmc Oxygen dependence of metabolic fluxes and energy generation of Saccharomyces cerevisiae CEN.PK113-1A
    Paula Jouhten
    VTT Technical Research Centre of Finland, Espoo, Finland
    BMC Syst Biol 2:60. 2008
    ..Oxygen is a major determinant of the physiology of S. cerevisiae but understanding of the oxygen dependence of intracellular flux distributions is still scarce...
  77. ncbi The extraordinary mitochondrion and unusual citric acid cycle in Trypanosoma brucei
    J J Van Hellemond
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands
    Biochem Soc Trans 33:967-71. 2005
    ..Despite the presence of all citric acid cycle enzymes in procyclic insect-stage T. brucei, citric acid cycle activity is not used for energy generation...
  78. pmc Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension
    Min Wei
    Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA
    PLoS Genet 5:e1000467. 2009
    ....
  79. ncbi Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans
    Joshua J McElwee
    Department of Biology, University College London, UK
    Mech Ageing Dev 127:458-72. 2006
    ..Down-regulation of the citric acid cycle and mitochondrial respiratory chain occurs in dauers, but not daf-2 adults...
  80. ncbi Can sugars be produced from fatty acids? A test case for pathway analysis tools
    Luis F de Figueiredo
    Department of Bioinformatics, Friedrich Schiller Universitat Jena, Ernst Abbe Platz 2, 07743 Jena, Germany
    Bioinformatics 24:2615-21. 2008
    ..Using this example, we can compare the various methods in pathway analysis...
  81. ncbi Metabolic maps and functions of the Plasmodium mitochondrion
    Giel G van Dooren
    Plant Cell Biology Research Centre, School of Botany, University of Melbourne, Parkville, Victoria, Australia
    FEMS Microbiol Rev 30:596-630. 2006
    ..The function of the tricarboxylic acid cycle in the mitochondrion is unclear. We discuss directions for future research into this fascinating, yet enigmatic, organelle...
  82. ncbi Krebs and his trinity of cycles
    H Kornberg
    Department of Biology, Boston University, 2 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Rev Mol Cell Biol 1:225-8. 2000
    ..It is appropriate, at the centenary of his birth, to consider the circumstances and experiments that led Krebs to establish these metabolic pathways...
  83. pmc NAD malic enzyme and the control of carbohydrate metabolism in potato tubers
    H L Jenner
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
    Plant Physiol 126:1139-49. 2001
    ..The effect on plastid metabolism may result from the observed glycolytic perturbations...
  84. pmc Role of gluconeogenesis and the tricarboxylic acid cycle in the virulence of Salmonella enterica serovar Typhimurium in BALB/c mice
    Merlin Tchawa Yimga
    Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI 02881
    Infect Immun 74:1130-40. 2006
    ....
  85. ncbi Geobacter sulfurreducens strain engineered for increased rates of respiration
    Mounir Izallalen
    Department of Microbiology, 203 Morril Science IV N, University of Massachusetts, Amherst, MA 01003, USA
    Metab Eng 10:267-75. 2008
    ..sulfurreducens in accordance with predictions from in silico metabolic modeling. To our knowledge, this is the first report of metabolic engineering to increase the respiratory rate of a microorganism...
  86. pmc Salmonella enterica serovar Typhimurium mutants unable to convert malate to pyruvate and oxaloacetate are avirulent and immunogenic in BALB/c mice
    Regino Mercado-Lubo
    Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI 028811, USA
    Infect Immun 77:1397-405. 2009
    ..g., arginine or ornithine, which might be available in mouse phagocytes...
  87. ncbi Analysis of Escherichia coli anaplerotic metabolism and its regulation mechanisms from the metabolic responses to altered dilution rates and phosphoenolpyruvate carboxykinase knockout
    Chen Yang
    Metabolome Unit, Institute for Advanced Biosciences, Keio University, Tsuruoka 997 0017, Japan
    Biotechnol Bioeng 84:129-44. 2003
    ..Combining the measurement data of in vivo fluxes, metabolite concentrations and enzyme activities, the in vivo regulations of PEP carboxykinase flux, PEP carboxylation, and glyoxylate shunt in E. coli are discussed...
  88. ncbi Revealing modular organization in the yeast transcriptional network
    Jan Ihmels
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel
    Nat Genet 31:370-7. 2002
    ..Our results provide functional predictions for numerous genes, identify relations between modules and present a global view on the transcriptional network...
  89. pmc Reduced expression of aconitase results in an enhanced rate of photosynthesis and marked shifts in carbon partitioning in illuminated leaves of wild species tomato
    Fernando Carrari
    Department Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Plant Physiol 133:1322-35. 2003
    ..Therefore, we conclude that the Krebs cycle normally competes with the Suc synthetic pathway for carbon but is not essential for the supply of energy to fuel the operation of this pathway...
  90. pmc A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti
    Elwood A Mullins
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Bacteriol 190:4933-40. 2008
    ..The citric acid cycle (CAC) is linked to acetic acid resistance in Acetobacter aceti by several observations, among them the ..
  91. ncbi Bidirectional reaction steps in metabolic networks: III. Explicit solution and analysis of isotopomer labeling systems
    W Wiechert
    IMR, Department of Simulation, University of Siegen, Paul Bonatz Strasse 9 11, D 57068 Siegen, Germany
    Biotechnol Bioeng 66:69-85. 1999
    ..Finally, some illustrative examples are examined to show that an information increase is not guaranteed when isotopomer measurements are used in addition to positional enrichment data...
  92. ncbi Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation
    Jean Jacques Briere
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 676, Hopital Robert Debre, Paris
    Am J Physiol Cell Physiol 291:C1114-20. 2006
    ....
  93. pmc Citric acid cycle in the hyperthermophilic archaeon Pyrobaculum islandicum grown autotrophically, heterotrophically, and mixotrophically with acetate
    Yajing Hu
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA
    J Bacteriol 188:4350-5. 2006
    The hyperthermophilic archaeon Pyrobaculum islandicum uses the citric acid cycle in the oxidative and reductive directions for heterotrophic and autotrophic growth, respectively, but the control of carbon flow is poorly understood. P...
  94. ncbi 13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells
    Gary W Cline
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 279:44370-5. 2004
    ....
  95. ncbi Flooding stress: acclimations and genetic diversity
    J Bailey-Serres
    Center for Plant Cell Biology, University of California, Riverside, California 92521, USA
    Annu Rev Plant Biol 59:313-39. 2008
    ....
  96. pmc Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Corynebacterium glutamicum
    D Molenaar
    Biotechnologisches Zentrallabor, Geb 25 12, Heinrich Heine Universitat, D 40225 Dusseldorf, Germany
    J Bacteriol 182:6884-91. 2000
    ..these activities are increased during growth on lactate, pyruvate, or acetate, substrates which require high citric acid cycle activity to sustain growth...
  97. ncbi Theoretical aspects of 13C metabolic flux analysis with sole quantification of carbon dioxide labeling
    Tae Hoon Yang
    Biochemical Engineering, Saarland University, Bldg 2, D 66123 Saarbrucken, Germany
    Comput Biol Chem 29:121-33. 2005
    ..The quality of information can be further increased by additional studies with [1,2-13C2] or [1,6-13C2] glucose. Respirometric tracer studies with sole labeling analysis of CO2 are therefore promising for 13C metabolic flux analysis...
  98. ncbi Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
    Mary A Selak
    Apoptosis and Tumour Physiology Laboratory, Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Switchback Road, Glasgow G61 1BD, United Kingdom
    Cancer Cell 7:77-85. 2005
    ..These results suggest a mechanistic link between SDH mutations and HIF-1alpha induction, providing an explanation for the highly vascular tumors that develop in the absence of VHL mutations...
  99. pmc A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: implications for the evolution of the mitochondrial Krebs cycle
    Anthony D Baughn
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:4662-7. 2002
    ..hutchinsonii was found to be most closely related to the mitochondrial/cytosolic IDH-2 group of eukaryotic organisms. These data suggest a common origin for these Krebs cycle enzymes in mitochondria and CFB group bacteria...
  100. pmc Bacillus subtilis metabolism and energetics in carbon-limited and excess-carbon chemostat culture
    M Dauner
    Institute of Biotechnology, , , Switzerland
    J Bacteriol 183:7308-17. 2001
    ..ATP-dependent control of in vivo enzyme activity appears to be irrelevant for the observed differences in TCA cycle fluxes...
  101. ncbi The yeast mitochondrial proteome, a study of fermentative and respiratory growth
    Steffen Ohlmeier
    Biocenter Oulu and Department of Biochemistry, P O Box 3000, University of Oulu, Oulu FIN 90014, Finland
    J Biol Chem 279:3956-79. 2004
    ..We propose that the discrepancy between proteome and transcriptional regulation, apart from different translation efficiency, indicates a changed turnover rate of proteins in different physiological conditions...

Research Grants12

  1. Regulation of energy metabolism in the failing heart
    Raymond Russell; Fiscal Year: 2005
    ..1) changes in the uptake and utilization of carbohydrate and fatty acid and their contribution to the citric acid cycle, 2) changes in the expression of key regulatory proteins in carbohydrate (the glucose transporters GLUT1 and ..
  2. Stereochemistry of Elimination and Proton Transfer
    JERRY MOHRIG; Fiscal Year: 2002
    ..They are important from fatty acid metabolism to glycolysis and the citric acid cycle, from terpene biosynthesis to the shikimic acid pathway...
  3. NEW AMINO ACID DISORDERS IN CEREBRAL DISEASE
    Vivian Shih; Fiscal Year: 1999
    ..1) In fumarase deficiency, a disorder of the citric acid cycle associated with severe neurologic impairment, the structural gene for human fumarase will be characterized ..
  4. Genotype and Metabolic Phenotype in Glioblastoma
    Elizabeth A Maher; Fiscal Year: 2010
    ..infusion of [U-13C]glucose or [1,2-13C]glucose to assess, respectively, the pathways intersecting in the citric acid cycle and relative flux through the pentose phosphate pathway...
  5. MECHANISM OF E. COLI PYRUVATE DEHYDROGENASE COMPLEX-E1
    Frank Jordan; Fiscal Year: 2004
    ..to initiate a series of reactions, a major product being acetyl-Coenzyme A, the starting material for the citric acid cycle. Among the specific goals for the requested period are: (1) Production of wild-type and variant El enzymes (..
  6. CONTROL OF EUCARYOTIC FUNCTION BY METHYLATION
    Steven Clarke; Fiscal Year: 2009
    ..discovered (trans-aconitate methyltransferase) that recognizes a spontaneously formed inhibitor of the citric acid cycle in a potential detoxification reaction...
  7. EFFECT OF EXERCISE ON PROTEIN DEGRADATION
    GEORGE KASPEREK; Fiscal Year: 1993
    ..The breakdown of protein leads to amino acids that can replenish the citric acid cycle intermediates that are lost by oxidative processes when the carbohydrate stores are low...
  8. STRUCTURE AND FUNCTION OF THE TRANSFERRIN RECEPTOR
    CAROLINE ENNS; Fiscal Year: 2002
    ..electron transport in the oxidative phosphorylation pathway in mitochondria, the activity of enzymes in the citric acid cycle, and the activity of proteins in many other essential metabolic and catabolic pathways in cells...
  9. CASE CONTROL/STUDY OF PARKINSONS DISEASE IN THE ELDERLY
    Richard Mayeux; Fiscal Year: 1999
    ..MPTP inhibits NADH-CoQ reductase (complex I) in mitochondria, whereas manganese inhibits the Citric Acid Cycle enzyme, mitochondrial aconitase (ACO2)...
  10. TRACER KINETICS EVALUATING POSITRON TOMOGRAPHY
    A Liedtke; Fiscal Year: 1993
    ..Protocols will be structured to address whether in the case of fatty acid and citric acid cycle metabolism time- activity curves generated by pulse labeling (assuming decay is from a single pool) ..
  11. CITRIC ACID CYCLE METABOLISM DURING CARDIAC SURGERY
    Michael Jessen; Fiscal Year: 2001
    ..proposes a series of studies which will quantify substrate utilization in pathways designed to replete citric acid cycle intermediates lost during myocardial ischemia under conditions encountered during routine cardiac surgery...
  12. Mammalian Heart Isocitrate Dehydrogenases
    ROBERTA COLMAN; Fiscal Year: 2004
    ..Isocitrate dehydrogenase catalyzes one of the rate limiting steps in the energy-producing Citric Acid Cycle. Evidence suggests that, in heart failure, decreases in the NAD enzyme are associated with decreased ..