energy metabolism

Summary

Top Publications

  1. ncbi Compendium of physical activities: an update of activity codes and MET intensities
    B E Ainsworth
    Department of Epidemiology and Biostatistics, School of Public Health, University of South Carolina, Columbia 29208, USA
    Med Sci Sports Exerc 32:S498-504. 2000
  2. pmc Identification and importance of brown adipose tissue in adult humans
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 360:1509-17. 2009
  3. ncbi Cold-activated brown adipose tissue in healthy men
    Wouter D van Marken Lichtenbelt
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, The Netherlands
    N Engl J Med 360:1500-8. 2009
  4. ncbi Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    Marie Lagouge
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 127:1109-22. 2006
  5. ncbi TSC2 mediates cellular energy response to control cell growth and survival
    Ken Inoki
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 115:577-90. 2003
  6. ncbi Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    Marc T Hamilton
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Diabetes 56:2655-67. 2007
  7. pmc AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Carles Canto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Nature 458:1056-60. 2009
  8. ncbi Functional brown adipose tissue in healthy adults
    Kirsi A Virtanen
    Turku PET Center, University of Turku, Finland
    N Engl J Med 360:1518-25. 2009
  9. ncbi Calibration of the Computer Science and Applications, Inc. accelerometer
    P S Freedson
    University of Massachusetts, Department of Exercise Science, Amherst 01003, USA
    Med Sci Sports Exerc 30:777-81. 1998
  10. ncbi An obesity-associated gut microbiome with increased capacity for energy harvest
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University, St Louis, Missouri 63108, USA
    Nature 444:1027-31. 2006

Detail Information

Publications317 found, 100 shown here

  1. ncbi Compendium of physical activities: an update of activity codes and MET intensities
    B E Ainsworth
    Department of Epidemiology and Biostatistics, School of Public Health, University of South Carolina, Columbia 29208, USA
    Med Sci Sports Exerc 32:S498-504. 2000
    ..The updated version includes two new major headings of volunteer and religious activities, extends the number of specific activities from 477 to 605, and provides updated MET intensity levels for selected activities...
  2. pmc Identification and importance of brown adipose tissue in adult humans
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 360:1509-17. 2009
    ....
  3. ncbi Cold-activated brown adipose tissue in healthy men
    Wouter D van Marken Lichtenbelt
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, The Netherlands
    N Engl J Med 360:1500-8. 2009
    ..Brown-adipose-tissue activity was studied in relation to body composition and energy metabolism.
  4. ncbi Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    Marie Lagouge
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 127:1109-22. 2006
    ..These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis...
  5. ncbi TSC2 mediates cellular energy response to control cell growth and survival
    Ken Inoki
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 115:577-90. 2003
    ..These observations demonstrate a model where TSC2 functions as a key player in regulation of the common mTOR pathway of protein synthesis, cell growth, and viability in response to cellular energy levels...
  6. ncbi Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    Marc T Hamilton
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Diabetes 56:2655-67. 2007
    ....
  7. pmc AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Carles Canto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Nature 458:1056-60. 2009
    ..Here we demonstrate that AMPK controls the expression of genes involved in energy metabolism in mouse skeletal muscle by acting in coordination with another metabolic sensor, the NAD+-dependent type ..
  8. ncbi Functional brown adipose tissue in healthy adults
    Kirsi A Virtanen
    Turku PET Center, University of Turku, Finland
    N Engl J Med 360:1518-25. 2009
    ....
  9. ncbi Calibration of the Computer Science and Applications, Inc. accelerometer
    P S Freedson
    University of Massachusetts, Department of Exercise Science, Amherst 01003, USA
    Med Sci Sports Exerc 30:777-81. 1998
    ..We established accelerometer count ranges for the Computer Science and Applications, Inc. (CSA) activity monitor corresponding to commonly employed MET categories...
  10. ncbi An obesity-associated gut microbiome with increased capacity for energy harvest
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University, St Louis, Missouri 63108, USA
    Nature 444:1027-31. 2006
    ..These results identify the gut microbiota as an additional contributing factor to the pathophysiology of obesity...
  11. ncbi TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    Karim Bensaad
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Cell 126:107-20. 2006
    ..The decrease of intracellular ROS levels in response to TIGAR may also play a role in the ability of p53 to protect from the accumulation of genomic damage...
  12. pmc A guide to analysis of mouse energy metabolism
    Matthias H Tschop
    Institute for Diabetes and Obesity, Helmholz Centre Munich, Department of Medicine, Technical University of Munich, Munich, Germany
    Nat Methods 9:57-63. 2012
    We present a consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models, including a practical guide to the assessment of energy expenditure, energy intake and body ..
  13. pmc Obesity and metabolic syndrome in circadian Clock mutant mice
    Fred W Turek
    Department of Neurology, Northwestern University, Evanston, IL 60208, USA
    Science 308:1043-5. 2005
    ..These results suggest that the circadian clock gene network plays an important role in mammalian energy balance...
  14. pmc Adipocytes as regulators of energy balance and glucose homeostasis
    Evan D Rosen
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 444:847-53. 2006
    ..Furthermore, the rational manipulation of adipose physiology is a promising avenue for therapy of these conditions...
  15. ncbi An energy budget for signaling in the grey matter of the brain
    D Attwell
    Department of Physiology, University College London, London, UK
    J Cereb Blood Flow Metab 21:1133-45. 2001
    ..Functional magnetic resonance imaging signals are likely to be dominated by changes in energy usage associated with synaptic currents and action potential propagation...
  16. ncbi Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
    ..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores...
  17. pmc Endocrine regulation of energy metabolism by the skeleton
    Na Kyung Lee
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 130:456-69. 2007
    ..this hypothesis we looked for genes expressed in osteoblasts, encoding signaling molecules and affecting energy metabolism. We show here that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected ..
  18. pmc Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    Silvie Timmers
    Top Institute Food and Nutrition TIFN, Wageningen, The Netherlands
    Cell Metab 14:612-22. 2011
    Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity...
  19. ncbi Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
    ..These metabolic alterations provide a mechanistic explanation for the growth advantage and apoptotic resistance of tumor cells...
  20. ncbi AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    Yasuhiko Minokoshi
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 428:569-74. 2004
    ..Thus, hypothalamic AMPK plays a critical role in hormonal and nutrient-derived anorexigenic and orexigenic signals and in energy balance...
  21. pmc Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    Xiaoqing Zhang
    Department of Physiology, University of Wisconsin Madison, Madison, WI 53706, USA
    Cell 135:61-73. 2008
    ....
  22. ncbi RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
    Duan Wu Zhang
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    Science 325:332-6. 2009
    ..Our data suggest that modulation of energy metabolism in response to death stimuli has an important role in the choice between apoptosis and necrosis.
  23. ncbi Effects of the obese gene product on body weight regulation in ob/ob mice
    M A Pelleymounter
    Department of Neurobiology, Amgen, Inc, Thousand Oaks, CA 91320, USA
    Science 269:540-3. 1995
    ..These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite...
  24. ncbi Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation
    Mireille Belanger
    Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne CH 1015, Switzerland
    Cell Metab 14:724-38. 2011
    ..This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.
  25. pmc Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    Mathieu Ferron
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 142:296-308. 2010
    ..Hence, in a feed-forward loop, insulin signals in osteoblasts activate a hormone, osteocalcin, that promotes glucose metabolism...
  26. ncbi AMP-activated protein kinase in metabolic control and insulin signaling
    Mhairi C Towler
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Circ Res 100:328-41. 2007
    ..It is a key player in the development of new treatments for obesity, type 2 diabetes, and the metabolic syndrome...
  27. pmc Limits to the measurement of habitual physical activity by questionnaires
    R J Shephard
    Br J Sports Med 37:197-206; discussion 206. 2003
    ....
  28. ncbi Validation and calibration of physical activity monitors in children
    Maurice R Puyau
    US Department of Agriculture, Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Obes Res 10:150-7. 2002
    ....
  29. ncbi Ghrelin enhances appetite and increases food intake in humans
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 86:5992. 2001
    ..Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man. Endogenous ghrelin is a potentially important new regulator of the complex systems controlling food intake and body weight...
  30. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake...
  31. pmc A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    Bong Hyun Ahn
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:14447-52. 2008
    ..These results implicate protein acetylation as an important regulator of Complex I activity and demonstrate that Sirt3 functions in vivo to regulate and maintain basal ATP levels...
  32. ncbi AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
    D Grahame Hardie
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK
    Nat Rev Mol Cell Biol 8:774-85. 2007
    ..Surprisingly, recent results indicate that the AMPK system is also important in functions that go beyond the regulation of energy homeostasis, such as the maintenance of cell polarity in epithelial cells...
  33. ncbi A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    P Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:829-39. 1998
    ..These results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis...
  34. ncbi UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    Helena M Feldmann
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Cell Metab 9:203-9. 2009
    ....
  35. ncbi Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
    ..These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis.
  36. ncbi Developmental plasticity and human health
    Patrick Bateson
    Sub Department of Animal Behaviour, University of Cambridge, High Street, Madingley, Cambridge CB3 8AA, UK
    Nature 430:419-21. 2004
    ..A fuller understanding of patterns of human plasticity in response to early nutrition and other environmental factors will have implications for the administration of public health...
  37. ncbi Anatomy and regulation of the central melanocortin system
    Roger D Cone
    Vollum Institute and the Center for the Study of Weight Regulation, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nat Neurosci 8:571-8. 2005
    ....
  38. pmc A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information
    Adam M Feist
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
    Mol Syst Biol 3:121. 2007
    ..The increased scope and computational capability using this new reconstruction is expected to broaden the spectrum of both basic biology and applied systems biology studies of E. coli metabolism...
  39. pmc Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Nat Med 16:1001-8. 2010
    ..These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone-induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis...
  40. pmc PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Curr Opin Lipidol 20:98-105. 2009
    ..In this review, we will focus on how disorders such as type 2 diabetes and the metabolic syndrome might be related to an abnormal and improper function of this network...
  41. pmc Nutrient sensing and inflammation in metabolic diseases
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:923-34. 2008
    ....
  42. pmc Test-retest reliability and construct validity of the ENERGY-child questionnaire on energy balance-related behaviours and their potential determinants: the ENERGY-project
    Amika S Singh
    VU University Medical Center, EMGO Institute for Health and Care Research, Dpt, of Public and Occupational Health, Amsterdam, The Netherlands
    Int J Behav Nutr Phys Act 8:136. 2011
    ..Therefore, reliable and valid tools to measure these variables in large-scale population research are needed...
  43. pmc Assessing mitochondrial dysfunction in cells
    Martin D Brand
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945, USA
    Biochem J 435:297-312. 2011
    ..Many other measurements in current use can be more problematic, as discussed in the present review...
  44. pmc PGC-1 coactivators in the control of energy metabolism
    Chang Liu
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, China
    Acta Biochim Biophys Sin (Shanghai) 43:248-57. 2011
    ..family of transcriptional coactivators is emerging as a hub linking nutritional and hormonal signals and energy metabolism. PGC-1α and PGC-1β are highly responsive to environmental cues and coordinate metabolic gene programs ..
  45. pmc New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    Yu Hua Tseng
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 454:1000-4. 2008
    ..These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity...
  46. pmc AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    Haihong Zong
    Howard Hughes Medical Institute and the Departments of Internal Medicine, Cell Biology, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15983-7. 2002
    ..These data demonstrate that by sensing the energy status of the muscle cell, AMPK is a critical regulator involved in initiating mitochondrial biogenesis...
  47. pmc PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death
    Sonia Gandhi
    Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, UK
    Mol Cell 33:627-38. 2009
    ..Our findings propose a mechanism by which PINK1 dysfunction renders neurons vulnerable to cell death...
  48. ncbi Divergence of melanocortin pathways in the control of food intake and energy expenditure
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell 123:493-505. 2005
    ..Disassociation of food intake and energy expenditure reveals unexpected divergence in melanocortin pathways controlling energy balance...
  49. ncbi The failing heart--an engine out of fuel
    Stefan Neubauer
    Department of Cardiovascular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom
    N Engl J Med 356:1140-51. 2007
  50. ncbi Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    Mitsuhiro Watanabe
    Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch, France
    Nature 439:484-9. 2006
    ..The BA-TGR5-cAMP-D2 signalling pathway is therefore a crucial mechanism for fine-tuning energy homeostasis that can be targeted to improve metabolic control...
  51. ncbi Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells
    Rodrigue Rossignol
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA
    Cancer Res 64:985-93. 2004
    ..We compared our finding on HeLa cells with those for nontransformed fibroblasts to help distinguish the regulatory pathways...
  52. pmc A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
    Vijay K Yadav
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 138:976-89. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  53. pmc Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view
    Gilad Twig
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA, USA
    Biochim Biophys Acta 1777:1092-7. 2008
    ....
  54. pmc Defining accelerometer thresholds for activity intensities in adolescent girls
    Margarita S Treuth
    Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Med Sci Sports Exerc 36:1259-66. 2004
    ....
  55. pmc AKT/PKB signaling: navigating downstream
    Brendan D Manning
    Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2 117, Boston, MA 02115, USA
    Cell 129:1261-74. 2007
    ..In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration...
  56. ncbi Energy metabolism in tumor cells
    Rafael Moreno-Sanchez
    Instituto Nacional de Cardiologia, Departamento de Bioquimica, Juan Badiano No 1, Tlalpan, Mexico DF 14080, Mexico
    FEBS J 274:1393-418. 2007
    In early studies on energy metabolism of tumor cells, it was proposed that the enhanced glycolysis was induced by a decreased oxidative phosphorylation...
  57. pmc MYC-induced cancer cell energy metabolism and therapeutic opportunities
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 15:6479-83. 2009
    ..Collectively, these studies indicate that Myc-mediated altered cancer cell energy metabolism could be translated for the development of new anticancer therapies.
  58. ncbi The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
    Robert Fredriksson
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Biomedical Center, Uppsala, Sweden
    Endocrinology 149:2062-71. 2008
    ..These results are consistent with the hypothesis that FTO could participate in the central control of energy homeostasis...
  59. pmc The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    Thomas Gerken
    Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
    Science 318:1469-72. 2007
    ..Studies can now be directed toward determining the physiologically relevant FTO substrate and how nucleic acid methylation status is linked to increased fat mass...
  60. ncbi STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    Sarah H Bates
    Research Division, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Nature 421:856-9. 2003
    ..LRb-STAT3 signalling thus mediates the effects of leptin on melanocortin production and body energy homeostasis, whereas distinct LRb signals regulate NPY and the control of fertility, growth and glucose homeostasis...
  61. ncbi Different metabolic responses of human brown adipose tissue to activation by cold and insulin
    Janne Orava
    Turku PET Centre, University of Turku, Turku, Finland
    Cell Metab 14:272-9. 2011
    ....
  62. ncbi Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    Harveen Dhillon
    Department of Medicine, Division of Endocrinology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Neuron 49:191-203. 2006
    ..These results reveal a critical role for leptin action on VMH neurons...
  63. pmc Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Pharmacol Rev 64:166-87. 2012
    ..We then analyze the pros and cons of the current strategies used to activate SIRT1 and explore the emerging evidence indicating that modulation of NAD(+) levels could provide an effective way to achieve such goals...
  64. ncbi The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression
    Rodrigo Diaz-Ruiz
    Oxygen Sensing and Cancer Laboratory, Ludwig Institute for Cancer Research Ltd, Karolinska Institute, Nobels väg 3, SE 171 77 Stockholm, Sweden
    Biochim Biophys Acta 1807:568-76. 2011
    ..In this paper we will review these common metabolic properties as well as the possible origins of the Crabtree and Warburg effects...
  65. ncbi Estimating physical activity energy expenditure, sedentary time, and physical activity intensity by self-report in adults
    Herve Besson
    Medical Research Council, Epidemiology Unit, Cambridge, UK
    Am J Clin Nutr 91:106-14. 2010
    ..Few questionnaires that assess usual physical activity have been reported to be valid for all different subdimensions of physical activity...
  66. ncbi Spontaneous network events driven by depolarizing GABA action in neonatal hippocampal slices are not attributable to deficient mitochondrial energy metabolism
    Eva Ruusuvuori
    Department of Biosciences, University of Helsinki, FI 00014 Helsinki, Finland
    J Neurosci 30:15638-42. 2010
    ..hippocampus and neocortex in vitro are pathophysiological phenomena, attributable to deficient mitochondrial energy metabolism. In their experiments, supplementing the glucose-containing solution with weak-acid substrates of ..
  67. pmc SirT1 gain of function increases energy efficiency and prevents diabetes in mice
    Alexander S Banks
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 8:333-41. 2008
    ..These findings have important implications for Sirtuin-based therapies in humans...
  68. ncbi Neurogenesis in the hypothalamus of adult mice: potential role in energy balance
    Maia V Kokoeva
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Science 310:679-83. 2005
    ..These findings link the sustained effect of CNTF on energy balance to hypothalamic neurogenesis and suggest that regulated hypothalamic neurogenesis in adult mice may play a previously unappreciated role in physiology and disease...
  69. pmc Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome
    Guang Yang
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Am J Physiol Endocrinol Metab 297:E211-24. 2009
    ..This study highlights a novel role for ceramide biosynthesis in body weight regulation, energy expenditure, and the metabolic syndrome...
  70. ncbi Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    P Puigserver
    Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
    Mol Cell 8:971-82. 2001
    ..These data illustrate a direct thermogenic action of cytokines and p38 MAP kinase through the transcriptional coactivator PGC-1...
  71. ncbi Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator
    Pere Puigserver
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115
    Endocr Rev 24:78-90. 2003
    ..Finally, PGC-1 alpha's control of energy homeostasis suggests that it could be a target for anti-obesity or diabetes drugs...
  72. pmc Amount of time spent in sedentary behaviors in the United States, 2003-2004
    Charles E Matthews
    Institute for Medicine and Public Health, Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232 1738, USA
    Am J Epidemiol 167:875-81. 2008
    ..These data provide the first objective measure of the amount of time spent in sedentary behavior in the US population and indicate that Americans spend the majority of their time in behaviors that expend very little energy...
  73. ncbi Ghrelin induces adiposity in rodents
    M Tschop
    Endocrine Research and BioResearch Technologies and Proteins, Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Nature 407:908-13. 2000
    ..We propose that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary...
  74. ncbi Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
    Ding An
    Div of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The Univ of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 291:H1489-506. 2006
    ..During insulin resistance or diabetes, the heart rapidly modifies its energy metabolism, resulting in augmented fatty acid and decreased glucose consumption...
  75. pmc Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming
    Clifford D L Folmes
    Center for Regenerative Medicine and Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cell Metab 14:264-71. 2011
    ..Thus, the energetic infrastructure of somatic cells transitions into a required glycolytic metabotype to fuel induction of pluripotency...
  76. ncbi Activity-dependent regulation of energy metabolism by astrocytes: an update
    Luc Pellerin
    Departement de Physiologie, Universite de Lausanne, Switzerland
    Glia 55:1251-62. 2007
    ....
  77. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..Evolutionary conservation has thus been accompanied by synergy, redundancy, and functional differentiation between DILPs, and these features may themselves be of evolutionary advantage...
  78. pmc AMP-activated protein kinase signaling in metabolic regulation
    Yun Chau Long
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Clin Invest 116:1776-83. 2006
    ..By responding to diverse hormonal signals including leptin and adiponectin, AMPK serves as an intertissue signal integrator among peripheral tissues, as well as the hypothalamus, in the control of whole-body energy balance...
  79. ncbi Mitochondrial energy metabolism and ageing
    Ivana Bratic
    Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases CECAD, University of Cologne, D 50674 Cologne, Germany
    Biochim Biophys Acta 1797:961-7. 2010
    ..In this review, we would like to point out the link between the mitochondrial energy balance and ageing, as well as a possible connection between the mitochondrial metabolism and molecular pathways important for the lifespan extension...
  80. pmc Supply and demand in cerebral energy metabolism: the role of nutrient transporters
    Ian A Simpson
    Department of Neural and Behavioral Sciences College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    J Cereb Blood Flow Metab 27:1766-91. 2007
    Glucose is the obligate energetic fuel for the mammalian brain, and most studies of cerebral energy metabolism assume that the majority of cerebral glucose utilization fuels neuronal activity via oxidative metabolism, both in the basal ..
  81. pmc Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    JAMA 295:1539-48. 2006
    ..Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabolic mass, has not been investigated in humans...
  82. pmc Metabolic reprogramming, caloric restriction and aging
    Rozalyn M Anderson
    Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Hospital, University of Wisconsin Madison, Madison, WI 53705, USA
    Trends Endocrinol Metab 21:134-41. 2010
    ..The inverse linear relationship between calorie intake and lifespan suggests that regulators of energy metabolism are important in the actions of CR...
  83. ncbi Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice
    T Nakagawa
    Sumitomo Pharmaceuticals Research Center, Discovery Research Laboratories II, Osaka, Japan
    Diabetes 49:436-44. 2000
    ..how blood glucose was metabolized in BDNF-treated animals, we investigated the effect of BDNF on the energy metabolism of db/db mice...
  84. ncbi Biochemistry, evolution and physiological function of the Rnf complex, a novel ion-motive electron transport complex in prokaryotes
    Eva Biegel
    Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt Main, Frankfurt, Germany
    Cell Mol Life Sci 68:613-34. 2011
    ..The energetics of the complex and its biochemistry, as well as its evolution and cellular function in different microbes, is discussed...
  85. pmc The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
    Zhaohui Feng
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Trends Cell Biol 20:427-34. 2010
    ..Recent studies revealed two additional functions of p53 in the regulation of IGF-1/AKT/mTOR pathways and energy metabolism, contributing to p53's role as a tumor suppressor...
  86. ncbi The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction
    Bérengère Coupé
    Institut National de la Recherche Agronomique, UMR 1280 Physiologie des Adaptations Nutritionnelles, Universite de Nantes, Nantes, France
    Am J Physiol Regul Integr Comp Physiol 297:R813-24. 2009
    ..Additionally, catch-up growth immediately after early malnutrition could be a key point for the programming of postprandial hyperleptinemia...
  87. pmc Metabolic impact of sex hormones on obesity
    Lynda M Brown
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27412, USA
    Brain Res 1350:77-85. 2010
    ..Understanding the mechanisms by which estrogens regulate body weight and inflammation will assist in determining potential therapeutic agents for menopausal women to decrease the propensity of diseases associated with obesity...
  88. ncbi Multiple defects in energy metabolism in Alzheimer's disease
    I L Ferreira
    Center for Neuroscience and Cellular Biology, University of Coimbra, Portugal
    Curr Drug Targets 11:1193-206. 2010
    ..Throughout the review, we further discuss several therapeutic strategies aimed to restore neuronal metabolic function in cellular and animal models of AD, some of which have reached the stage of clinical trials...
  89. ncbi Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
    Yun S Lee
    Department of Biological Sciences, Seoul National University, San 56 1, Sillim dong, Kwanak gu, Korea
    Diabetes 55:2256-64. 2006
    ..These findings suggest that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity...
  90. pmc Objectively measured sedentary time may predict insulin resistance independent of moderate- and vigorous-intensity physical activity
    Hendrik J F Helmerhorst
    Medical Research Council Epidemiology Unit, Cambridge, UK
    Diabetes 58:1776-9. 2009
    ....
  91. ncbi Metabolic biomarkers related to energy metabolism in Saudi autistic children
    O A Al-Mosalem
    Biochemistry Department, Science College, King Saud University, P O Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    Clin Biochem 42:949-57. 2009
    b>Energy metabolism is usually manipulated in many neurodegenerative diseases...
  92. ncbi Spontaneous emergence of leaders and followers in foraging pairs
    Sean A Rands
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nature 423:432-4. 2003
    ..Moreover, the strategy that gives rise to this behaviour can be implemented by a simple 'rule of thumb' that requires no detailed knowledge of the state of other individuals...
  93. ncbi The role of the gut microbiota in energy metabolism and metabolic disease
    Patrice D Cani
    Universite Catholique de Louvain, Louvain Drug Research Institute, Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Brussels, Belgium
    Curr Pharm Des 15:1546-58. 2009
    ..Several mechanisms are proposed linking events occurring in the colon and the regulation of energy metabolism, such as i.e...
  94. ncbi Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    Lazaros A Nikolaidis
    Department of Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Circulation 110:955-61. 2004
    ....
  95. ncbi Physical activity assessment with accelerometers: an evaluation against doubly labeled water
    Guy Plasqui
    Department of Biomedical Science, University of Wollongong, Wollongong, Australia
    Obesity (Silver Spring) 15:2371-9. 2007
    ..Of those commercially available, only the CSA/MTI/Actigraph has been proven to correlate reasonably with DLW-derived energy expenditure...
  96. pmc Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans
    Christina Pfannenberg
    Department of Diagnostic and Interventional Radiology, University of Tubingen, Tubingen, Germany
    Diabetes 59:1789-93. 2010
    ..In the present study we addressed this hypothesis and further investigated the effect of age on the sex differences in BAT activity and BAT mass...
  97. ncbi Evaluation of the SenseWear Pro Armband to assess energy expenditure during exercise
    John M Jakicic
    Physical Activity and Weight Management Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Med Sci Sports Exerc 36:897-904. 2004
    ..To assess the accuracy of the SenseWear Pro Armband for estimating energy expenditure during exercise...
  98. ncbi The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough
    John F Heidelberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nat Biotechnol 22:554-9. 2004
    Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and ..
  99. ncbi Molecular hydrogen as an energy source for Helicobacter pylori
    Jonathan W Olson
    Department of Microbiology, University of Georgia, Athens, GA 30602, USA
    Science 298:1788-90. 2002
    ..Therefore, hydrogen present in animals as a consequence of normal colonic flora is an energy-yielding substrate that can facilitate the maintenance of a pathogenic bacterium...
  100. ncbi Evaluation of a portable device to measure daily energy expenditure in free-living adults
    Maxime St-Onge
    Metabolic Dysfunction Laboratory, Nutrition Department, University of Montreal, Montreal, Canada
    Am J Clin Nutr 85:742-9. 2007
    ..Increasing daily energy expenditure (EE) plays an important role in the prevention or treatment of several lifestyle-related diseases; however, its measurement remains problematic...
  101. pmc Modulation of energy transfer pathways between mitochondria and myofibrils by changes in performance of perfused heart
    Marko Vendelin
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, 12618 Tallinn, Estonia
    J Biol Chem 285:37240-50. 2010
    ..Our results provide experimental evidence for the existence of two pathways of energy transfer, direct ATP transfer, and PCr transfer through the CK shuttle, whose contribution may vary depending on the metabolic status of the heart...

Research Grants12

  1. REGULATION OF C1 METABOLISM IN METHYLOTROPHS
    Mary Lidstrom; Fiscal Year: 2007
    ..developed a model for how the cell controls formaldehyde flux to achieve a dynamic balance of carbon and energy metabolism, avoiding formaldehyde toxicity...
  2. Therapy for Liver Cancer by Targeting Energy Metabolism
    Jean Francois Geschwind; Fiscal Year: 2007
    ..is to develop a new therapeutic strategy consisting of direct intraarterial delivery of potent inhibitors of energy metabolism to treat liver cancer...
  3. DEVELOPMENT EFFECT ON LOOP DIURETIC OTOTOXICITY
    Leonard Rybak; Fiscal Year: 1999
    ..change and which could influence ototoxic sensitivity to loop diuretics include; glucose utilization/energy metabolism in the cochlea (Aim 1) drug distribution and an immature blood-labyrinth barrier (Aim 2) hepatic metabolism ..
  4. SIRT1 Overexpression in Cellular Mitochondrial Metabolism and Function
    James Russell; Fiscal Year: 2009
    ..transcription factor PGC-11 leading to increased mitochondrial regeneration and improved cellular oxidative energy metabolism. The role of SIRT1 and its mechanism/s of action at cellular level are uncertain;however investigators with ..
  5. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1993
    ..overall objective of this proposal to characterize and elucidate the mechanism(s) involved in regulation of energy metabolism by atriopeptins in perfused rat livers and perfused hepatocytes...
  6. Regulation of energy metabolism in the failing heart
    Raymond Russell; Fiscal Year: 2005
    ..However, the effect of increased glucose uptake and decreased fatty acid uptake on substrate energy metabolism is not know. Furthermore, the signaling pathway responsible for this switch is unclear...
  7. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1991
    ..vasopressin, angiotensin, glucagon and insulin on the key regulatory processes involved in carbohydrate energy metabolism. Initially studies will be performed to elucidate the effects of the various hormones described above on the ..
  8. Role of Tumor and Stromal Cell Metabolism in Stress Adaptation and Progression
    EILEEN contact WHITE; Fiscal Year: 2010
    ..broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-CA-112: Cancer Cell Energy Metabolism and Cancer Causation The molecular events that covert normal cells into tumor cells alter cellular ..
  9. Broadly Neuroprotective Drug for TBI
    Fernando Gomez Pinilla; Fiscal Year: 2010
    ..we will evaluate the ability of CNB-001 supplemented in the diet to restore synaptic plasticity and energy metabolism disrupted after TBI, in conjunction with CNB-001 effects on counteracting cognitive, mood disorders, and ..
  10. Role of NPC1L1 in regulating energy metabolism, nutrient utilization & weight gai
    Philip N Howles; Fiscal Year: 2010
    ....
  11. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..If found in clinical studies, this pathway connecting bone and energy metabolism could lead to new approaches for preserving insulin sensitivity and production with implications for ..
  12. Diagnosis of Cardiac Viability by Functional Ultrasound
    Marek Belohlavek; Fiscal Year: 2005
    ..We found that experimental pharmacologic inhibition of myocyte energy metabolism in s selected myocardial region leads to reproducible intramyocardial mechanical aberrations...