electron transport

Summary

Summary: The process by which ELECTRONS are transported from a reduced substrate to molecular OXYGEN. (From Bennington, Saunders Dictionary and Encyclopedia of Laboratory Medicine and Technology, 1984, p270)

Top Publications

  1. pmc The cell-non-autonomous nature of electron transport chain-mediated longevity
    Jenni Durieux
    The Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 144:79-91. 2011
  2. ncbi Mitochondrial respiratory-chain diseases
    Salvatore DiMauro
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 348:2656-68. 2003
  3. ncbi Mitochondrial ROS-induced ROS release: an update and review
    Dmitry B Zorov
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Biochim Biophys Acta 1757:509-17. 2006
  4. ncbi Topology of superoxide production from different sites in the mitochondrial electron transport chain
    Julie St-Pierre
    MRC Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, England
    J Biol Chem 277:44784-90. 2002
  5. ncbi Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase
    Celio X C Santos
    Vascular Biology Laboratory, Heart Institute InCor, University of Sao Paulo School of Medicine, CEP 05403 000, Sao Paulo, Brazil
    Antioxid Redox Signal 11:2409-27. 2009
  6. ncbi Architecture of succinate dehydrogenase and reactive oxygen species generation
    Victoria Yankovskaya
    Molecular Biology Division, VA Medical Center, San Francisco, CA 94121, USA
    Science 299:700-4. 2003
  7. pmc Photosynthetic electron transport regulates the expression of cytosolic ascorbate peroxidase genes in Arabidopsis during excess light stress
    S Karpinski
    Department of Applied Genetics, John Innes Centre, Norwich Research Park, Colney, United Kingdom
    Plant Cell 9:627-40. 1997
  8. ncbi Architecture of the photosynthetic oxygen-evolving center
    Kristina N Ferreira
    Department of Biological Sciences, Imperial College London, London, SW7 2AZ, UK
    Science 303:1831-8. 2004
  9. ncbi Production of reactive oxygen species by mitochondria: central role of complex III
    Qun Chen
    Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:36027-31. 2003
  10. ncbi Respiratory active mitochondrial supercomplexes
    Rebeca Acín-Pérez
    Departamento de Bioquimica, Universidad de Zaragoza, Miguel Servet, 177, 50013 Zaragoza, Spain
    Mol Cell 32:529-39. 2008

Detail Information

Publications341 found, 100 shown here

  1. pmc The cell-non-autonomous nature of electron transport chain-mediated longevity
    Jenni Durieux
    The Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 144:79-91. 2011
    ..that regulators of mitochondrial stress responses are essential and specific genetic requirements for the electron transport chain (ETC) longevity pathway...
  2. ncbi Mitochondrial respiratory-chain diseases
    Salvatore DiMauro
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 348:2656-68. 2003
  3. ncbi Mitochondrial ROS-induced ROS release: an update and review
    Dmitry B Zorov
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Biochim Biophys Acta 1757:509-17. 2006
    ..RIRR could be a general cell biology phenomenon relevant to the processes of programmed mitochondrial destruction and cell death, and may contribute to other mechanisms of post-ischemic pathologies, including arrhythmias...
  4. ncbi Topology of superoxide production from different sites in the mitochondrial electron transport chain
    Julie St-Pierre
    MRC Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, England
    J Biol Chem 277:44784-90. 2002
    ..By using different substrates and inhibitors, we determined the sites of production (which complexes in the electron transport chain produced superoxide)...
  5. ncbi Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase
    Celio X C Santos
    Vascular Biology Laboratory, Heart Institute InCor, University of Sao Paulo School of Medicine, CEP 05403 000, Sao Paulo, Brazil
    Antioxid Redox Signal 11:2409-27. 2009
    ..ER oxidoreductases including flavooxidase Ero1 and protein disulfide isomerase (PDI); (b) Mitochondrial electron transport; (c) Nox4 NADPH oxidase complex, particularly Nox4...
  6. ncbi Architecture of succinate dehydrogenase and reactive oxygen species generation
    Victoria Yankovskaya
    Molecular Biology Division, VA Medical Center, San Francisco, CA 94121, USA
    Science 299:700-4. 2003
    ..SQR), analogous to the mitochondrial respiratory complex II, has been determined, revealing the electron transport pathway from the electron donor, succinate, to the terminal electron acceptor, ubiquinone...
  7. pmc Photosynthetic electron transport regulates the expression of cytosolic ascorbate peroxidase genes in Arabidopsis during excess light stress
    S Karpinski
    Department of Applied Genetics, John Innes Centre, Norwich Research Park, Colney, United Kingdom
    Plant Cell 9:627-40. 1997
    ..Measurements of photosynthetic parameters and the use of electron transport inhibitors indicated that a novel signal transduction pathway was initiated at plastoquinone and regulated, ..
  8. ncbi Architecture of the photosynthetic oxygen-evolving center
    Kristina N Ferreira
    Department of Biological Sciences, Imperial College London, London, SW7 2AZ, UK
    Science 303:1831-8. 2004
    ..The details of the surrounding coordination sphere of the metal cluster and the implications for a possible oxygen-evolving mechanism are discussed...
  9. ncbi Production of reactive oxygen species by mitochondria: central role of complex III
    Qun Chen
    Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:36027-31. 2003
    ..Limitation of electron transport by the inhibitor rotenone immediately before ischemia decreases the production of ROS in cardiac myocytes ..
  10. ncbi Respiratory active mitochondrial supercomplexes
    Rebeca Acín-Pérez
    Departamento de Bioquimica, Universidad de Zaragoza, Miguel Servet, 177, 50013 Zaragoza, Spain
    Mol Cell 32:529-39. 2008
    ..Therefore, we have demonstrated the existence of a functional respirasome and propose a structural organization model that accommodates these findings...
  11. ncbi Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production
    Masaaki Korenaga
    Center for Hepatitis Research, Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, 77555, USA
    J Biol Chem 280:37481-8. 2005
    ..In addition, there was reduced activity of electron transport complex I, and increased ROS production from complex I substrates...
  12. ncbi Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum
    Heather J Painter
    Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    Nature 446:88-91. 2007
    ..stages of the human malaria parasite Plasmodium falciparum seem to maintain an active mitochondrial electron transport chain to serve just one metabolic function: regeneration of ubiquinone required as the electron acceptor for ..
  13. ncbi Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species
    Anatoly A Starkov
    Department of Neurology and Neuroscience, Weill Medical College, Cornell University, New York, New York 10021, USA
    J Neurosci 24:7779-88. 2004
    ..are not well established but are generally thought to be located in complex I and complex III of the electron transport chain...
  14. ncbi Crystal structure of mitochondrial respiratory membrane protein complex II
    Fei Sun
    Tsinghua IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing 100084, China
    Cell 121:1043-57. 2005
    ..The Complex II structure provides a bona fide model for study of the mitochondrial respiratory system and human mitochondrial diseases related to mutations in this complex...
  15. ncbi The dynamics of photosynthesis
    Stephan Eberhard
    Universite Pierre et Marie Curie, Institut de Biologie Physico Chimique, F 75005 Paris, France
    Annu Rev Genet 42:463-515. 2008
    ....
  16. pmc Mitochondrial electron transport is the cellular target of the oncology drug elesclomol
    Ronald K Blackman
    Synta Pharmaceuticals Corp, Lexington, Massachusetts, United States of America
    PLoS ONE 7:e29798. 2012
    ..Specifically, the results indicate that elesclomol, driven by its redox chemistry, interacts with the electron transport chain (ETC) to generate high levels of ROS within the organelle and consequently cell death...
  17. ncbi Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
    J Feng
    Department of Biology, McGill University, 1205 Avenue Dr Penfield, H3A 1B1, , , Canada
    Dev Cell 1:633-44. 2001
    ..These findings indicate that both isp-1 and daf-2 mutations increase life span by lowering oxidative stress and result in the maximum life span increase that can be produced in this way...
  18. ncbi Electron transfer by domain movement in cytochrome bc1
    Z Zhang
    E O Lawrence Berkeley National Laboratory, University of California, 94720, USA
    Nature 392:677-84. 1998
    ..Such a mechanism has not previously been observed in redox protein complexes...
  19. ncbi Electrochemical interrogations of the Mtr cytochromes from Shewanella: opening a potential window
    Mackenzie Firer-Sherwood
    Department of Chemistry, Boston University, 590 Commonwealth Ave, Boston, MA 02215, USA
    J Biol Inorg Chem 13:849-54. 2008
    ..These data are taken together to suggest a model of electron transport where a wide window of potential allows for charge transfer from the cellular interior to the exterior to ..
  20. pmc Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria
    Wagner L Araujo
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Golm, Germany
    Plant Cell 22:1549-63. 2010
    ....
  21. ncbi In vivo and in organello assessment of OXPHOS activities
    Antoni Barrientos
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Methods 26:307-16. 2002
    ....
  22. ncbi Biochemistry, evolution and physiological function of the Rnf complex, a novel ion-motive electron transport complex in prokaryotes
    Eva Biegel
    Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt Main, Frankfurt, Germany
    Cell Mol Life Sci 68:613-34. 2011
    Microbes have a fascinating repertoire of bioenergetic enzymes and a huge variety of electron transport chains to cope with very different environmental conditions, such as different oxygen concentrations, different electron acceptors, pH ..
  23. ncbi Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
    Alisdair R Fernie
    Department of Lothar Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 7:254-61. 2004
    The respiratory pathways of glycolysis, the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain are ubiquitous throughout nature...
  24. ncbi Cyclic electron flow around photosystem I is essential for photosynthesis
    Yuri Munekage
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0101, Japan
    Nature 429:579-82. 2004
    ..The cytochrome b6f complex mediates electron transport between the two photosystems and generates the proton gradient (DeltapH)...
  25. ncbi Chlorophyll fluorescence: a probe of photosynthesis in vivo
    Neil R Baker
    Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ, United Kingdom
    Annu Rev Plant Biol 59:89-113. 2008
    ..Finally, applications of fluorescence imaging to studies of photosynthetic heterogeneity and the rapid screening of large numbers of plants for perturbations in photosynthesis and associated metabolism are considered...
  26. ncbi Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I)
    Adrian J Lambert
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 279:39414-20. 2004
    Neither the route of electron transport nor the sites or mechanism of superoxide production in mitochondrial complex I has been established...
  27. pmc Respiration of metal (hydr)oxides by Shewanella and Geobacter: a key role for multihaem c-type cytochromes
    Liang Shi
    Pacific Northwest National Laboratory, Richland, Washington 99354, USA
    Mol Microbiol 65:12-20. 2007
    ..Thus, multihaem c-Cyts play critical roles in S. oneidensis MR-1- and G. sulfurreducens-mediated dissimilatory reduction of solid metal (hydr)oxides by facilitating ET across the bacterial cell envelope...
  28. ncbi Experimental conditions affect the site of tetrazolium violet reduction in the electron transport chain of Lactococcus lactis
    Sybille Tachon
    INRA, UR 477 Biochimie Bactérienne, F 78350 Jouy en Josas, France
    Microbiology 155:2941-8. 2009
    ..tests, TV reduction resulted from electron transfer from an intracellular donor (mainly NADH) to TV via the electron transport chain (ETC), but the reduction sites in the ETC depended on experimental conditions...
  29. pmc The Mtr respiratory pathway is essential for reducing flavins and electrodes in Shewanella oneidensis
    Dan Coursolle
    Biotechnology Institute, University of Minnesota, Paul, MN 55108, USA
    J Bacteriol 192:467-74. 2010
    ..The parallel phenotypes of Mtr mutants in flavin and electrode reduction blur the distinction between direct contact and the redox shuttling strategies of insoluble substrate reduction by MR-1...
  30. pmc Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells
    Melissa A Fath
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA
    Cancer Biol Ther 8:1228-36. 2009
    Increasing evidence suggests that cancer cells (relative to normal cells) have altered mitochondrial electron transport chains (ETC) that are more likely to form reactive oxygen species (ROS; i.e...
  31. ncbi Chlororespiration and cyclic electron flow around PSI during photosynthesis and plant stress response
    Dominique Rumeau
    Laboratoire d Ecophysiologie Moléculaire des Plantes, CEA Cadarache, DSV, IBEB, SBVME, UMR 6191 CNRS CEA Université Aix Marseilles, Saint Paul lez Durance F 13108, France
    Plant Cell Environ 30:1041-51. 2007
    ..In response to severe stress conditions, PTOX associated to the NDH and/or the PGR5 pathway may also limit electron pressure on PSI acceptor and prevent PSI photoinhibition...
  32. ncbi Photosynthetic control of electron transport and the regulation of gene expression
    Christine H Foyer
    Centre for Plant Sciences, Faculty of Biology, University of Leeds, Leeds LS2 9JT, UK
    J Exp Bot 63:1637-61. 2012
    ..control' describes the short- and long-term mechanisms that regulate reactions in the photosynthetic electron transport (PET) chain so that the rate of production of ATP and NADPH is coordinated with the rate of their ..
  33. ncbi Reduction of nitrate in Shewanella oneidensis depends on atypical NAP and NRF systems with NapB as a preferred electron transport protein from CymA to NapA
    Haichun Gao
    College of Life Sciences and Institute of Microbiology, Zhejiang University, Hangzhou, Zhejiang, China
    ISME J 3:966-76. 2009
    ..These two systems seem to be atypical because the genome lacks genes encoding cytoplasmic membrane electron transport proteins, NapC for NAP and NrfBCD/NrfH for NRF, respectively...
  34. pmc Towards electrosynthesis in shewanella: energetics of reversing the mtr pathway for reductive metabolism
    Daniel E Ross
    The Biotechnology Institute, University of Minnesota Twin Cities, St Paul, Minnesota, United States of America
    PLoS ONE 6:e16649. 2011
    ..This work demonstrates that the Mtr pathway can power reductive reactions, shows this conduit is functionally reversible, and provides new evidence for distinct CymA:MtrA and CymA:FccA respiratory units...
  35. pmc Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1
    Thorsten Althoff
    Abteilung Strukturbiologie, Max Planck Institut fur Biophysik, Frankfurt, Germany
    EMBO J 30:4652-64. 2011
    ..The arrangement of respiratory chain complexes suggests two possible pathways for efficient electron transfer through the supercomplex, of which the shorter branch through the complex III monomer proximal to complex I may be preferred...
  36. pmc Secretion of flavins by Shewanella species and their role in extracellular electron transfer
    Harald von Canstein
    School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom
    Appl Environ Microbiol 74:615-23. 2008
    ..The implications of flavin secretion by Shewanella cells living at redox boundaries, where these mineral phases can be significant electron acceptors for growth, are discussed...
  37. pmc Mitochondrial DNA mutations in human colonic crypt stem cells
    Robert W Taylor
    Department of Neurology, The Medical School, University of Newcastle upon Tyne, United Kingdom
    J Clin Invest 112:1351-60. 2003
    ..These studies have important consequences not only for understanding of the finding of mtDNA mutations in aging tissues and tumors, but also for determining the frequency of mtDNA mutations within a cell...
  38. ncbi OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion
    Claudia Zanna
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Via Irnerio 42, 40126 Bologna, Italy
    Brain 131:352-67. 2008
    ..The results disclose a novel link between OPA1, apoptosis inducing factor and the respiratory complexes that may shed some light on the pathogenic mechanism of DOA...
  39. pmc Evolution of electron transfer out of the cell: comparative genomics of six Geobacter genomes
    Jessica E Butler
    Department of Microbiology, University of Massachusetts, Amherst, MA, USA
    BMC Genomics 11:40. 2010
    ..Conservation of proteins across the genomes was determined to better understand the evolution of Geobacter species and to create a metabolic model applicable to subsurface environments...
  40. ncbi Cyclic electron transport around photosystem I: genetic approaches
    Toshiharu Shikanai
    Graduate School of Agriculture, Kyushu University, Fukuoka, Japan 812 8581
    Annu Rev Plant Biol 58:199-217. 2007
    ..The reactions involve two types of electron flow in the chloroplast. While linear electron transport generates both ATP and NADPH, photosystem I cyclic electron transport is exclusively involved in ATP ..
  41. ncbi Towards the molecular mechanism of respiratory complex I
    Judy Hirst
    Medical Research Council Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, U K
    Biochem J 425:327-39. 2010
    ..The present review summarizes and evaluates experimental data that pertain to the reaction mechanisms of complex I, and describes and discusses contemporary mechanistic hypotheses, proposals and models...
  42. ncbi Downregulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-alpha
    Ingrid Dahlman
    Department of Medicine, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Diabetes 55:1792-9. 2006
    ..Downregulation of several genes in the electron transport chain was the most prominent finding in visceral fat of type 2 diabetic women independent of obesity, but ..
  43. pmc An Arabidopsis mutant with high cyclic electron flow around photosystem I (hcef) involving the NADPH dehydrogenase complex
    Aaron K Livingston
    Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164 6340, USA
    Plant Cell 22:221-33. 2010
    ....
  44. ncbi Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease
    Fernando Scaglia
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Pediatrics 114:925-31. 2004
    ..The aim of this study was to elucidate the frequency of major clinical manifestations in children with mitochondrial disease and establish their clinical course, prognosis, and rates of survival depending on their clinical features...
  45. pmc Cyclic electron flow around photosystem I in C(3) plants. In vivo control by the redox state of chloroplasts and involvement of the NADH-dehydrogenase complex
    Thierry Joet
    Commissariat à l Energie Atomique Cadarache, Département d Ecophysiologie Végétale et de Microbiologie, Unité Mixte de Recherche 163 Centre National de la Recherche Scientifique, F 13108 Saint Paul lez Durance, France
    Plant Physiol 128:760-9. 2002
    ..We conclude that the Ndh complex is required for rapid electron cycling around PS I...
  46. ncbi Biochemistry, physiology and biotechnology of sulfate-reducing bacteria
    Larry L Barton
    Department of Biology, University of New Mexico, MSCO3 2020, Albuquerque, New Mexico 87131, USA
    Adv Appl Microbiol 68:41-98. 2009
    ..sulfate-reducing bacteria) constitute a unique physiological group of microorganisms that couple anaerobic electron transport to ATP synthesis...
  47. pmc Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum
    Heather J Painter
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Antimicrob Agents Chemother 54:5281-7. 2010
    Although mitochondrial electron transport is a validated target of the antimalarial drug atovaquone, the molecular details underlying parasite demise are unclear...
  48. pmc Mitochondrial complex II has a key role in mitochondrial-derived reactive oxygen species influence on plant stress gene regulation and defense
    Cynthia Gleason
    Commonwealth Scientific and Industrial Research Organisation Plant Industry, Wembley, WA 6913, Australia
    Proc Natl Acad Sci U S A 108:10768-73. 2011
    ..We provide genetic proof that mitochondrial complex II (Complex II) of the electron transport chain contributes to localized mROS that regulates plant stress and defense responses...
  49. ncbi Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint
    Tohru Yamamori
    Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Free Radic Biol Med 53:260-70. 2012
    ..mitochondrial respiration, and mitochondrial ATP production, suggesting upregulation of the mitochondrial electron transport chain (ETC) function after Ir...
  50. ncbi Auxiliary electron transport pathways in chloroplasts of microalgae
    Gilles Peltier
    CEA, Direction des Sciences du Vivant, Institut de Biologie Environnementale et de Biotechnologie, Laboratoire de Bioénergétique et Biotechnologie des Bactéries et Microalgues, CEA Cadarache, Saint Paul lez Durance 13108, France
    Photosynth Res 106:19-31. 2010
    ..and Synechocystis for cyanobacteria allowed identifying molecular components involved in these auxiliary electron transport pathways, including Ndh-1, Ndh-2, PGR5, PGRL1, PTOX and flavodiiron proteins...
  51. ncbi Regulation of electron transport in microalgae
    Pierre Cardol
    Laboratoire de génétique des microorganismes, Institut de Botanique, Universite de Liege, 27 bld du rectorat, B 4000 Liege, Belgium
    Biochim Biophys Acta 1807:912-8. 2011
    ..This article is part of a Special Issue entitled: Regulation of Electron Transport in Chloroplasts.
  52. ncbi Distinct responses of the mitochondrial respiratory chain to long- and short-term high-light environments in Arabidopsis thaliana
    Keisuke Yoshida
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Plant Cell Environ 34:618-28. 2011
    ..These results suggest that AOX plays an important role in rapid acclimation of the respiratory chain to sHL, which may support efficient photosynthetic performance...
  53. pmc Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation
    Erin L Seifert
    Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 285:5748-58. 2010
    ..Finally, ROS production was sensitive to matrix levels of LCFA catabolic intermediates, indicating that mitochondrial export of LCFA catabolic intermediates can play a role in determining ROS levels...
  54. pmc Deficiency of the mitochondrial electron transport chain in muscle does not cause insulin resistance
    Dong Ho Han
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 6:e19739. 2011
    ..insulin resistance in type 2 diabetes is due to a selective decrease in the components of the mitochondrial electron transport chain and results from accumulation of toxic products of incomplete fat oxidation...
  55. ncbi Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila
    Dickon M Humphrey
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, Department of Neuroscience, King s College London, London, UK
    Hum Mol Genet 21:2698-712. 2012
    ....
  56. ncbi Effect of a polymeric surfactant on electron transport in HL-60 cells
    N Rapoport
    Department of Bioengineering, University of Utah, Salt Lake City 84112, USA
    Arch Biochem Biophys 384:100-8. 2000
    To assess the effect of a polymeric surfactant, Pluronic P-105 on the activity of electron transport chains in the mitochondria of HL-60 cells, the bioreduction rates of two membrane-localized lipophilic spin probes, 16-doxylstearic acid ..
  57. pmc Current production and metal oxide reduction by Shewanella oneidensis MR-1 wild type and mutants
    Orianna Bretschger
    Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, USA
    Appl Environ Microbiol 73:7003-12. 2007
    ..Overall, these data suggest a very complex picture of electron transfer to solid and soluble substrates by S. oneidensis MR-1...
  58. ncbi Physiological diversity of mitochondrial oxidative phosphorylation
    G Benard
    INSERM U688, Physiopathologie Mitochondriale, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Am J Physiol Cell Physiol 291:C1172-82. 2006
    ..To conclude, we submitted our data to a principal component analysis that revealed three groups of tissues: muscle and heart, brain, and liver and kidney...
  59. pmc Intermonomer electron transfer between the low-potential b hemes of cytochrome bc₁
    Pascal Lanciano
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Biochemistry 50:1651-63. 2011
    ..Overall findings are discussed with respect to intra- and intermonomer interactions that take place during the catalytic turnover of cyt bc(1)...
  60. pmc Kinetic characterization of OmcA and MtrC, terminal reductases involved in respiratory electron transfer for dissimilatory iron reduction in Shewanella oneidensis MR-1
    Daniel E Ross
    Center for Environmental Kinetics Analysis, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Appl Environ Microbiol 75:5218-26. 2009
    ..This work supports the hypothesis that electron shuttles are important participants in the reduction of solid Fe phases by this organism...
  61. pmc Cloning and sequence of cymA, a gene encoding a tetraheme cytochrome c required for reduction of iron(III), fumarate, and nitrate by Shewanella putrefaciens MR-1
    C R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Bacteriol 179:1143-52. 1997
    ..The localization of the fumarate and iron(III) reductases to the periplasm and outer membrane of MR-1, respectively, suggests the possibility of a similar electron transfer role for CymA...
  62. ncbi Effects of a high-fat diet on energy metabolism and ROS production in rat liver
    Guillaume Vial
    INSERM, U884, Grenoble, F 38041 France
    J Hepatol 54:348-56. 2011
    ..Steatosis is still poorly understood since diverse effects have been reported, depending on the different experimental models used...
  63. pmc DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon
    Ryan W Honaker
    Department of Microbiology, University of Colorado Denver, School of Medicine, P18 9115, 12800 East 19th Avenue, PO Box 6511, Aurora, Colorado 80045, USA
    J Bacteriol 192:6447-55. 2010
    ..The menaquinone pool is central to the electron transport system (ETS) and therefore provides a mechanistic link between the respiratory state of the bacilli and DosS ..
  64. pmc Engineering of a synthetic electron conduit in living cells
    Heather M Jensen
    Department of Chemistry and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:19213-8. 2010
    ....
  65. pmc An electronic bus bar lies in the core of cytochrome bc1
    Monika Swierczek
    Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Science 329:451-4. 2010
    ..Free and unregulated distribution of electrons acts like a molecular-scale bus bar, a design often exploited in electronics...
  66. pmc Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation
    Mariana G Rosca
    Department of Medicine, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland 44106 4981, OH, USA
    Cardiovasc Res 80:30-9. 2008
    Mitochondrial dysfunction is a major factor in heart failure (HF). A pronounced variability of mitochondrial electron transport chain (ETC) defects is reported to occur in severe acquired cardiomyopathies without a consistent trend for ..
  67. ncbi Roles of the twin-arginine translocase and associated chaperones in the biogenesis of the electron transport chains of the human pathogen Campylobacter jejuni
    Andrew Hitchcock
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Microbiology 156:2994-3010. 2010
    The zoonotic pathogen Campylobacter jejuni NCTC 11168 uses a complex set of electron transport chains to ensure growth with a variety of electron donors and alternative electron acceptors, some of which are known to be important for host ..
  68. ncbi The role of multihaem cytochromes in the respiration of nitrite in Escherichia coli and Fe(III) in Shewanella oneidensis
    Thomas A Clarke
    Centre for Molecular and Structural Biology, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem Soc Trans 36:1005-10. 2008
    ..UV-visible spectroscopy indicated that all five haems were low-spin, consistent with the presence of bis-His ligand co-ordination as found in full-length MtrA...
  69. pmc Rubisco in planta kcat is regulated in balance with photosynthetic electron transport
    H Eichelmann
    Department of Plant Physiology and Biophysics, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia
    J Exp Bot 60:4077-88. 2009
    ..The Cyt b(6)f level was measured in planta by maximum electron transport rate and the photosystem I (PSI) content was assessed by titration with far-red light...
  70. ncbi The structure of cbb3 cytochrome oxidase provides insights into proton pumping
    Sabine Buschmann
    Max Planck Institut fur Biophysik, Max von Laue Strasse 3, D 60438 Frankfurt Main, Germany
    Science 329:327-30. 2010
    ..Structural differences around hemes b and b3 suggest a different redox-driven proton-pumping mechanism and provide clues to explain the higher activity of family-C HCOs at low oxygen concentrations...
  71. ncbi Sympatric Drosophila simulans flies with distinct mtDNA show difference in mitochondrial respiration and electron transport
    Subhash D Katewa
    Ramaciotti Centre for Gene Function Analysis, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia
    Insect Biochem Mol Biol 37:213-22. 2007
    ..This study compares mitochondrial respiration, proton leak and electron transport of Drosophila simulans males with distinct mtDNA haplogroups (siII and -III) that were collected in sympatry ..
  72. ncbi A sulphite respiration system in the chemoheterotrophic human pathogen Campylobacter jejuni
    Jonathan D Myers
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Microbiology 151:233-42. 2005
    ..Sulphite respiration may be of importance for survival in environmental microaerobic niches and some foods, and may also provide a detoxification mechanism for this normally growth-inhibitory compound...
  73. pmc Arabidopsis PPR40 connects abiotic stress responses to mitochondrial electron transport
    Laura Zsigmond
    Institute of Plant Biology, Biological Research Centre, Hungarian Academy of Sciences, 6726 Szeged, Hungary
    Plant Physiol 146:1721-37. 2008
    Oxidative respiration produces adenosine triphosphate through the mitochondrial electron transport system controlling the energy supply of plant cells...
  74. pmc Characterization of an electron conduit between bacteria and the extracellular environment
    Robert S Hartshorne
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Proc Natl Acad Sci U S A 106:22169-74. 2009
    ..We have identified the MtrAB module in a range of bacterial phyla, suggesting that it is widely used in electron exchange with the extracellular environment...
  75. pmc Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice
    Rajindar S Sohal
    Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, PSC 608, Los Angeles, CA 90089 9121, USA
    Free Radic Biol Med 40:480-7. 2006
    ..Activities of mitochondrial electron transport chain oxidoreductases, rates of mitochondrial O2-* generation, state 3 respiration, carbonyl content, ..
  76. ncbi Mitochondrial respiratory chain super-complex I-III in physiology and pathology
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1797:633-40. 2010
    ..There is increasing evidence that disruption of the super-complex organization leads to functional derangements responsible for pathological changes, as we have found in K-ras-transformed fibroblasts...
  77. ncbi Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease
    Kalpita Banerjee
    Department of Biochemistry, Institute of Postgraduate Medical Education and Research, Kolkata, India
    FEBS Lett 584:1571-6. 2010
    ..The results are significant in view of the fact that alpha-synucleinopathy is involved in the pathogenesis of Parkinson's disease...
  78. ncbi Generation of reactive oxygen species by the mitochondrial electron transport chain
    Yuanbin Liu
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 9062, USA
    J Neurochem 80:780-7. 2002
    Generation of reactive oxygen species (ROS) by the mitochondrial electron transport chain (ETC), which is composed of four multiprotein complexes named complex I-IV, is believed to be important in the aging process and in the pathogenesis ..
  79. pmc Shewanella secretes flavins that mediate extracellular electron transfer
    Enrico Marsili
    BioTechnology Institute and Department of Microbiology, University of Minnesota, St Paul, MN 55108, USA
    Proc Natl Acad Sci U S A 105:3968-73. 2008
    ..Moreover, the known ability of isoalloxazine rings to act as metal chelators, along with their electron shuttling capacity, suggests that extracellular respiration of minerals by Shewanella is more complex than originally conceived...
  80. pmc Green fluorescent proteins are light-induced electron donors
    Alexey M Bogdanov
    Shemiakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
    Nat Chem Biol 5:459-61. 2009
    ..Moreover, via green-to-red GFP photoconversion, this process can be observed in living cells without additional treatment...
  81. pmc Mitochondrial proton and electron leaks
    Martin Jastroch
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Essays Biochem 47:53-67. 2010
    ..The second part of the chapter focuses on the electron leak that occurs in the mitochondrial electron transport chain...
  82. ncbi State transitions at the crossroad of thylakoid signalling pathways
    Sylvain Lemeille
    Department of Molecular Biology and Plant Biology, University of Geneva, 30, Quai Ernest Ansermet, 1211 Geneva, Switzerland
    Photosynth Res 106:33-46. 2010
    ..In this article, we present a review on recent developments in the area of state transitions...
  83. pmc Arabidopsis STN7 kinase provides a link between short- and long-term photosynthetic acclimation
    Paolo Pesaresi
    Dipartimento di Produzione Vegetale, Università degli studi di Milano c o Parco Tecnologico Padano Via Einstein, 26900 Lodi, Italy
    Plant Cell 21:2402-23. 2009
    ..becomes critical for photosynthesis in Arabidopsis thaliana mutants that are impaired in thylakoid electron transport but retain a functional LTR...
  84. ncbi Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice
    S Hauptmann
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, 60438 Frankfurt, Germany
    Neurobiol Aging 30:1574-86. 2009
    ..We conclude that Ass dependent mitochondrial dysfunction starts already at 3 months in this AD model before extracellular deposition of Ass and progression accelerates substantially with aging...
  85. pmc Isolation of a high-affinity functional protein complex between OmcA and MtrC: Two outer membrane decaheme c-type cytochromes of Shewanella oneidensis MR-1
    Liang Shi
    Microbiology Group, Pacific Northwest National Laboratory, 902 Battelle Blvd, P O Box 999, MSIN P7 50, Richland, WA 99354, USA
    J Bacteriol 188:4705-14. 2006
    ..activity relative to either protein alone, demonstrating that OmcA and MtrC can interact directly with each other to form a stable complex that is consistent with their role in the electron transport pathway of S. oneidensis MR-1.
  86. ncbi Yarrowia lipolytica, a yeast genetic system to study mitochondrial complex I
    Stefan Kerscher
    Universitatsklinikum Frankfurt, Institut fur Biochemie I, Zentrum der Biologischen Chemie, Theodor Stern Kai 7, Haus 25 B, D 60590 Frankfurt am Main, Germany
    Biochim Biophys Acta 1555:83-91. 2002
    ..lipolytica complex I. Characterization of a number of mutations already allowed for the identification of several functionally important amino acids, demonstrating the usefulness of this approach...
  87. pmc The PPH1 phosphatase is specifically involved in LHCII dephosphorylation and state transitions in Arabidopsis
    Alexey Shapiguzov
    Department of Plant Biology, University of Geneva, 1211 Geneve 4, Switzerland
    Proc Natl Acad Sci U S A 107:4782-7. 2010
    ..These two proteins emerge as key players in the adaptation of the photosynthetic apparatus to changes in light quality and quantity...
  88. ncbi Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice
    Maria I Rodriguez
    Instituto de Biotecnologia, Departamento de Fisiologia, Universidad de Granada, Facultad de Medicina, Granada, Spain
    Exp Gerontol 43:749-56. 2008
    ..mitochondrial oxidative damage in the diaphragm of SAMP8 mice was accompanied by a reduction in the electron transport chain complex activities and in ATP levels...
  89. ncbi Diagnostic criteria for respiratory chain disorders in adults and children
    F P Bernier
    Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville VIC 3052, Australia
    Neurology 59:1406-11. 2002
    ..Respiratory chain (RC) disorders are clinically, biochemically, and molecularly heterogeneous. The lack of standardized diagnostic criteria poses difficulties in evaluating diagnostic methodologies...
  90. ncbi Electron transfer in syntrophic communities of anaerobic bacteria and archaea
    Alfons J M Stams
    Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
    Nat Rev Microbiol 7:568-77. 2009
    ..Anaerobic methane oxidation coupled to sulphate reduction is also carried out by syntrophic communities of bacteria and archaea but, as we discuss, the exact mechanism of this syntrophic interaction is not yet understood...
  91. ncbi Determining the limitations and regulation of photosynthetic energy transduction in leaves
    Neil R Baker
    Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ, Essex, UK
    Plant Cell Environ 30:1107-25. 2007
    ..Non-invasive probing of electron fluxes through PSI and PSII, and proton fluxes across the thylakoid membranes can provide insights into the operation of such regulatory processes in vivo...
  92. ncbi Somatic mitochondrial DNA mutations in mammalian aging
    Nils Goran Larsson
    Max Planck Institute for Biology of Ageing, Cologne D 50931, Germany
    Annu Rev Biochem 79:683-706. 2010
    ..The roles for mtDNA damage and replication errors in aging need to be further experimentally addressed...
  93. ncbi Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria
    Qun Chen
    Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Cell Physiol 294:C460-6. 2008
    ..The reversible blockade of electron transport with amobarbital during ischemia protects mitochondrial respiration and decreases myocardial injury during ..
  94. ncbi Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts
    Chwen Ming Shih
    Department of Biochemistry, School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
    J Cell Biochem 91:384-97. 2004
    ..Using inhibitors of the mitochondrial electron transport chain (ETC) (oligomycin A and rotenone for complex I and V, respectively) and mitochondrial permeability ..
  95. ncbi Crystal structure of plant photosystem I
    Adam Ben-Shem
    Department of Biochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Nature 426:630-5. 2003
    ....
  96. pmc Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure
    Sung W Choi
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 109:1179-91. 2009
    ..In this study, we test the hypothesis that partial restriction of electron transport through Complexes I and II in synaptosomes to mimic possible defects associated with Parkinson's and ..
  97. pmc PdhR (pyruvate dehydrogenase complex regulator) controls the respiratory electron transport system in Escherichia coli
    Hiroshi Ogasawara
    Department of Frontier Bioscience, Hosei University, Kajino cho 3 7 2, Koganei, Tokyo 184 8584, Japan
    J Bacteriol 189:5534-41. 2007
    ..II, and cyoABCDE, encoding the cytochrome bo-type oxidase, both together forming the pathway of respiratory electron transport downstream from the PDH cycle...
  98. pmc Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans
    M J Falk
    Division of Human Genetics, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA
    Mol Genet Metab 93:388-97. 2008
    ..Such knowledge may enable the development of a metabolomic profiling diagnostic tool applicable to human mitochondrial disease...
  99. ncbi Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes
    Pablo R Castello
    The Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Cell Metab 3:277-87. 2006
    ....
  100. ncbi Tools for resolving complexity in the electron transfer networks of multiheme cytochromes c
    Mackenzie A Firer-Sherwood
    Department of Chemistry, Metcalf Science Center, 590 Commonwealth Avenue, Boston, MA 02215, USA
    Metallomics 3:344-8. 2011
    ..Through use of these techniques, we are able to confirm the transient interactions between these cytochromes, supporting the model of electron transfer that is present in the literature...
  101. pmc Function of Ech hydrogenase in ferredoxin-dependent, membrane-bound electron transport in Methanosarcina mazei
    Cornelia Welte
    Institute of Microbiology and Biotechnology, University of Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany
    J Bacteriol 192:674-8. 2010
    ..of a Methanosarcina mazei Delta ech mutant which shows decreased ferredoxin-dependent membrane-bound electron transport activity, a lower growth rate, and faster substrate consumption...

Research Grants12

  1. METABOLISM AND NUTRITION OF IRON AND OTHER TRACE METALS
    PAUL SALTMAN; Fiscal Year: 1993
    ..principal research goals are to understand: 1) The mechanisms by which intracellular and intramolecular electron transport regulate and control Fe(lll) and Cu(ll) metabolism; 2) How Fe(lll) and Cu(ll) in the presence of reducing ..
  2. Indicators of early neurodegeneration: gene-toxin interactions at the syanpse
    Felix E Schweizer; Fiscal Year: 2010
    ..PD-linked genes code for mitochondrial proteins and some pesticides linked to PD inhibit the mitochondrial electron transport chain...
  3. MITOCHONDRIAL IRON-SULFUR PROTEINS
    Michael Johnson; Fiscal Year: 1991
    ..proposal is a molecular understanding of the mitochondrial respiratory chain, with particular emphasis on electron transport and redox-linked proton translocation...
  4. ELECTRON TRANSPORT ENZYMES IN CATECHOLAMINE GRANULES
    Patrick Fleming; Fiscal Year: 1990
    ..DBH was not previously known to be allosterically regulated. Thus, this characterization is necessary to permit an understanding of the regulation of catecholamine biosynthesis...
  5. Control of Cardiac Metabolism: NADH Shuttles/Hypertrophy
    Thomas Scholz; Fiscal Year: 2006
    ..maintenance of the redox ratio by oxidizing NADH in the cytosol and delivering reducing equivalents to the electron transport chain within the mitochondria...
  6. STRUCTURE AND FUNCTION OF THE TRANSFERRIN RECEPTOR
    CAROLINE ENNS; Fiscal Year: 2002
    Iron is necessary for the enzymatic activity of key proteins in the DNA synthetic pathway, electron transport in the oxidative phosphorylation pathway in mitochondria, the activity of enzymes in the citric acid cycle, and the activity of ..
  7. Cardiolipin Function in Mitochondrial Electron-Transfer Complexes
    Neal C Robinson; Fiscal Year: 2011
    ..mechanisms by which cardiolipin (CL) binding affects the structure and function of three mitochondrial electron transport complexes: cytochrome c oxidase, cytochrome bc1, and NADH dehydrogenase (Complex I)...
  8. Enhancement of Cancer Therapy Using Ketogenic Diets
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2010
    ..oxidative stress mediated by O2"- and H2O2, with a major site of pro-oxidant production being mitochondrial electron transport chain complexes...
  9. MITOCHONDRIA INCREASE OXIDATIVE INJURY IN AGING HEART
    EDWARD LESNEFSKY JR; Fiscal Year: 1999
    ..We propose that increased ischemic electron transport damage in the elderly heart will lead to greater OH production...
  10. Charge Transfer Reactions of the Cytochrome bc1 Complex
    Colin A Wraight; Fiscal Year: 2011
    ..by applicant): The cytochrome (cyt) bc1 complex plays a central role in respiratory and photosynthetic electron transport chains, but is also implicated in the production of damaging free radicals and reactive oxygen species ..
  11. Diaphragm Mitochondrial Alterations in Sepsis
    Leigh Callahan; Fiscal Year: 2004
    ..dysfunction in sepsis results from physiologic derangements of Krebs cycle enzymes, Complex I-IV electron transport chain components, and sarcomericcreatine kinase, (b) these physiologic changes are due, in turn, to ..
  12. ELECTRON TRANSPORT VARIANTS IN STAPHYLOCOCCAL DISEASE
    Richard Proctor; Fiscal Year: 2001
    ..Dr. Proctor recently reported that an electron transport deficient subpopulation of organisms can be responsible for antibiotic failures and for late recurrences ..