capillary permeability

Summary

Summary: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.

Top Publications

  1. ncbi Signaling mechanisms regulating endothelial permeability
    Dolly Mehta
    Center of Lung and Vascular Biology, Dept of Pharmacology M C 868, University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Physiol Rev 86:279-367. 2006
  2. ncbi Pathophysiological consequences of VEGF-induced vascular permeability
    Sara M Weis
    Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093 0803, USA
    Nature 437:497-504. 2005
  3. ncbi The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications
    Elisabetta Dejana
    IFOM, The FIRC Institute of Molecular Oncology, Milan, Italy
    Dev Cell 16:209-21. 2009
  4. ncbi Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0452, USA
    Science 286:2511-4. 1999
  5. ncbi Cytoskeletal regulation of pulmonary vascular permeability
    S M Dudek
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol 91:1487-500. 2001
  6. ncbi Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Nat Med 7:575-83. 2001
  7. ncbi Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    D A Antonetti
    Penn State Retina Research Group, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 274:23463-7. 1999
  8. pmc Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
    J G Garcia
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Invest 108:689-701. 2001
  9. pmc Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo
    M Corada
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 96:9815-20. 1999
  10. ncbi Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor
    Keith L Black
    Maxine Dunitz Neurosurgical Institute and Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Cancer Control 11:165-73. 2004

Research Grants

Detail Information

Publications303 found, 100 shown here

  1. ncbi Signaling mechanisms regulating endothelial permeability
    Dolly Mehta
    Center of Lung and Vascular Biology, Dept of Pharmacology M C 868, University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Physiol Rev 86:279-367. 2006
    ....
  2. ncbi Pathophysiological consequences of VEGF-induced vascular permeability
    Sara M Weis
    Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093 0803, USA
    Nature 437:497-504. 2005
    ..Therefore, by blocking the vascular permeability promoting effects of VEGF it may be feasible to reduce tissue injury after ischaemic disease and minimize the invasive properties of circulating tumour cells...
  3. ncbi The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications
    Elisabetta Dejana
    IFOM, The FIRC Institute of Molecular Oncology, Milan, Italy
    Dev Cell 16:209-21. 2009
    ..In this review we discuss recent findings derived from these approaches and their possible integration in a common picture...
  4. ncbi Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0452, USA
    Science 286:2511-4. 1999
    ..Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels...
  5. ncbi Cytoskeletal regulation of pulmonary vascular permeability
    S M Dudek
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol 91:1487-500. 2001
    ..The critical role of the endothelial cytoskeleton in integrating these multiple aspects of pulmonary vascular permeability provides a fertile area for the development of clinically important barrier-modulating therapies...
  6. ncbi Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Nat Med 7:575-83. 2001
    ..By upregulating PlGF and the signaling subtype of VEGFR-1, endothelial cells amplify their responsiveness to VEGF during the 'angiogenic switch' in many pathological disorders...
  7. ncbi Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors
    D A Antonetti
    Penn State Retina Research Group, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 274:23463-7. 1999
    ..In conclusion, VEGF rapidly increases occludin phosphorylation as well as the tyrosine phosphorylation of ZO-1. Phosphorylation of occludin and ZO-1 likely contribute to regulated endothelial paracellular permeability...
  8. pmc Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
    J G Garcia
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Invest 108:689-701. 2001
    ..Platelet-released Sph-1-P, linked to Rac- and Rho-dependent cytoskeletal rearrangement, may act late in angiogenesis to stabilize newly formed vessels, which often display abnormally increased vascular permeability...
  9. pmc Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo
    M Corada
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 96:9815-20. 1999
    ..These data indicate that VE-cadherin is required for vascular integrity and normal organ functions...
  10. ncbi Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor
    Keith L Black
    Maxine Dunitz Neurosurgical Institute and Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Cancer Control 11:165-73. 2004
    ..The blood-brain tumor barrier (BTB) significantly impedes delivery of most hydrophilic molecules to brain tumors. Several promising strategies, however, have been developed to overcome this problem...
  11. ncbi Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    Ricky T Tong
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 64:3731-6. 2004
    ..Thus, vascular normalization may contribute to the improved survival rates in tumor-bearing animals and in colorectal carcinoma patients treated with an anti-VEGF antibody in combination with cytotoxic therapies...
  12. ncbi Brain endothelial cells and the glio-vascular complex
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076 Tubingen, Germany
    Cell Tissue Res 335:75-96. 2009
    ....
  13. pmc Murine model for dengue virus-induced lethal disease with increased vascular permeability
    Sujan Shresta
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 80:10208-17. 2006
    ..This report represents a significant advance in animal models for severe DEN disease, and it begins to provide mechanistic insights into DEN-induced disease in vivo...
  14. pmc Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation
    Kunihiko Hatanaka
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8017, USA
    Am J Physiol Heart Circ Physiol 300:H162-72. 2011
    ..These findings demonstrate that VE-cadherin, through the regulation of Y658 phosphorylation, competes for junctional localization with N-cadherin and controls vascular permeability and endothelial cell migration...
  15. ncbi Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties
    N Perriere
    CNRS UMR 7157, INSERM U705, University Paris 7, University Paris 5, Hopital Fernand Widal, Paris, France
    J Neurochem 93:279-89. 2005
    ..In conclusion, this method of RBEC purification will allow the production of in vitro models of the rat blood-brain barrier for cellular and molecular biology studies as well as pharmacological investigations...
  16. ncbi Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability
    Chinnaswamy Tiruppathi
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Ill 60612, USA
    Circ Res 91:70-6. 2002
    ..These results show that TRPC4-dependent Ca2+ entry in mouse LECs is a key determinant of increased microvascular permeability...
  17. pmc Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability
    Tomoaki Murakami
    Department of Cellular and Molecular Physiology and Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 284:21036-46. 2009
    ..These data demonstrate a novel mechanism of VEGF-induced occludin phosphorylation and ubiquitination that contributes to TJ trafficking and subsequent vascular permeability...
  18. ncbi Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
    Matthew R Dreher
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    J Natl Cancer Inst 98:335-44. 2006
    ..We investigated how molecular weight influences the accumulation of a model macromolecular drug carrier, dextran covalently linked to a fluorophore, in tumors...
  19. ncbi Interleukin-1beta -induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study
    A M Blamire
    Medical Research Council Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Neurosci 20:8153-9. 2000
    ..Thus the action of IL-1beta alone can give rise to magnetic resonance imaging-visible changes that are normally attributed to alterations to cellular homeostasis...
  20. pmc The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species
    Elizabeth Monaghan-Benson
    Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 284:25602-11. 2009
    ..Collectively, these data suggest that VEGF leads to a Rac-mediated generation of ROS, which, in turn, elevates the tyrosine phosphorylation of VE-cadherin and beta-catenin, ultimately regulating adherens junction integrity...
  21. pmc Intercellular adhesion molecule-1-dependent neutrophil adhesion to endothelial cells induces caveolae-mediated pulmonary vascular hyperpermeability
    Guochang Hu
    Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Ave, Chicago, IL 60612, USA
    Circ Res 102:e120-31. 2008
    ....
  22. ncbi Plasma leakage in dengue haemorrhagic fever
    Anon Srikiatkhachorn
    University of Massachusetts Medical School, Center for Infectious Diseases and Vaccine Research, Worcester, MA 01655 0002, USA
    Thromb Haemost 102:1042-9. 2009
    ..Insights into the mechanisms that confer protection or cause disease are critical in the development of prophylactic and therapeutic modalities for this important disease...
  23. ncbi Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications
    Hiroshi Maeda
    Department of Microbiology, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Int Immunopharmacol 3:319-28. 2003
    ..Consequently, drastic reduction of the systemic side effect is observed, while the macromolecular drugs will continuously exert antitumor activity. Other advantages of macromolecular drugs are also discussed...
  24. ncbi Caveolin-1 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide
    Sean Garrean
    Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, 835 South Wolcott Avenue, Chicago, IL 60612, USA
    J Immunol 177:4853-60. 2006
    ..Thus, caveolin-1, through its ability to regulate eNOS-derived NO production, is a crucial determinant of NF-kappaB activation and the lung inflammatory response to LPS...
  25. ncbi Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro
    Thorsten Nitz
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Wilhelm Klemm Strasse 2, 48149 Munster, Germany
    Brain Res 981:30-40. 2003
    ..Although the structure of the 67 kDa factor could not be analysed, this finding is of importance for in vitro models not only of the blood-brain barrier mostly using serum-containing media...
  26. ncbi Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema
    R J Kaner
    Division of Pulmonary and Critical Care Medicine and Weill Medical College of Cornell University, New York, New York, USA
    Am J Respir Cell Mol Biol 22:657-64. 2000
    ..wet/dry weight ratios over time, lung histology showed widespread intra- alveolar edema, and pulmonary capillary permeability was significantly increased as quantified by the Evans blue dye assay and [(131)I]albumin permeability...
  27. pmc Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator
    Rong Jin
    Department of Neurosurgery, LSU Health Science Center, Shreveport, LA 71130, USA
    Neurobiol Dis 38:376-85. 2010
    ..We discuss how MMPs and tPA contribute to BBB disruption during ischemic stroke and highlight recent findings of molecular signaling pathways involved in neurotoxicity of tPA therapy...
  28. ncbi Ultrasound targeted microbubble destruction increases capillary permeability in hepatomas
    Raffi Bekeredjian
    Internal Medicine III, University of Heidelberg, Heidelberg, Germany
    Ultrasound Med Biol 33:1592-8. 2007
    ..Taking advantage of high local concentrations of therapeutic substances and transiently increased capillary permeability, UTMD could be used for the treatment of ultrasound accessible tumors...
  29. ncbi Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity
    Juliana P Zuliani
    Laboratorio de Farmacologia, Instituto Butantan, Sao Paulo, Brazil
    Toxicon 45:335-46. 2005
    ..However, the fact that MT-II induced inflammation suggests that molecular regions distinct from the catalytic site elicit inflammatory events perhaps by interacting with specific cell membrane acceptors...
  30. pmc The role of cytoskeleton in the regulation of vascular endothelial barrier function
    Natalia V Bogatcheva
    Medical College of Georgia, Vascular Biology Center, Augusta, GA 30912, USA
    Microvasc Res 76:202-7. 2008
    ..This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential...
  31. ncbi Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth
    Michelle I Lin
    Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536, USA
    Cancer Res 67:2849-56. 2007
    ..Thus, the loss of Cav-1 increases tumor permeability and growth and that may relate to enhanced VEGF signaling due to lack of Cav-1 inhibition of VEGFR-2 or decreased VE-cadherin mediated VEGFR-2 phosphorylation...
  32. pmc Molecular mechanisms of endothelial hyperpermeability: implications in inflammation
    Puneet Kumar
    Division of Research, Department of Surgery, University of California at Davis School of Medicine, Sacramento, CA 95758, USA
    Expert Rev Mol Med 11:e19. 2009
    ..Targeting key signalling molecules that mediate endothelial-junction-cytoskeleton dissociation demonstrates a therapeutic potential to improve vascular barrier function during inflammatory injury...
  33. pmc Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
    Mohammad Tauseef
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Circ Res 103:1164-72. 2008
    ..Our results suggest the crucial role of activation of the SPHK1-->S1P-->S1P1 signaling pathway in response to inflammatory mediators in endothelial cells in regulating endothelial barrier homeostasis...
  34. ncbi Tracer kinetic modelling in MRI: estimating perfusion and capillary permeability
    S P Sourbron
    Division of Medical Physics, University of Leeds, Leeds, West Yorkshire, UK
    Phys Med Biol 57:R1-33. 2012
    ..In particular, models of the second generation enable separate estimates of perfusion and capillary permeability rather than a single parameter K(trans) that represents a combination of the two...
  35. pmc VEGF-induced vascular permeability is mediated by FAK
    Xiao Lei Chen
    Department of Reproductive Medicine, Moores UCSD Cancer Center, La Jolla, CA 92093, USA
    Dev Cell 22:146-57. 2012
    ..Our studies establish a role for FAK as an essential signaling switch within ECs regulating adherens junction dynamics...
  36. pmc Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function
    Peter V Usatyuk
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Microvasc Res 83:45-55. 2012
    ....
  37. pmc A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability
    Julie Gavard
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA
    Mol Cell Biol 29:2469-80. 2009
    ..These findings indicate that the CXCR2 and PI3Kgamma signaling pathway may represent a suitable target for the development of novel therapeutic strategies for human diseases characterized by vascular leakage...
  38. pmc Vascular permeability, vascular hyperpermeability and angiogenesis
    Janice A Nagy
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Angiogenesis 11:109-19. 2008
    ..Further work will be required to elucidate the signaling pathways by which each of these molecules, and others likely to be discovered, mediate the different types of vascular permeability...
  39. ncbi Celecoxib, a selective cyclooxygenase-2 inhibitor, inhibits retinal vascular endothelial growth factor expression and vascular leakage in a streptozotocin-induced diabetic rat model
    Surya P Ayalasomayajula
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha 68198 6025, USA
    Eur J Pharmacol 458:283-9. 2003
    ..Thus, celecoxib reaches the retina after oral administration and reduces diabetes-induced retinal VEGF mRNA expression and vascular leakage by inhibiting the activity of cyclooxygenase-2 enzyme...
  40. pmc Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever
    Anon Srikiatkhachorn
    Center for Infectious Diseases and Vaccine Research, Rm S5 326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 81:1592-600. 2007
    ..Dengue virus-induced changes in surface and soluble VEGFR2 expression may be an important mechanism of plasma leakage in DHF...
  41. pmc Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat
    David Fernández-López
    Department of Neurology, University of California San Francisco, San Francisco, California 94143 0633, USA
    J Neurosci 32:9588-600. 2012
    ..The markedly more integrant BBB in neonatal brain than in adult brain after acute stroke may have major implications for the treatment of neonatal stroke...
  42. pmc VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd
    Zuyue Sun
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
    J Exp Med 209:1363-77. 2012
    ..Histamine-induced extravasation was not affected by TSAd deficiency. We conclude that TSAd is required for VEGF-induced, c-Src-mediated regulation of endothelial cell junctions and for vascular permeability...
  43. pmc Latent KSHV infection increases the vascular permeability of human endothelial cells
    Christophe Guilluy
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, USA
    Blood 118:5344-54. 2011
    ....
  44. ncbi Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment
    Rob Cairns
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, CCSR South, Room 1245, Stanford, CA 94305 5152, USA
    Mol Cancer Res 4:61-70. 2006
    ..Novel molecular strategies designed to interfere with the activities of these gene products are being devised as ways to overcome the physiologic barriers in the tumor to standard anticancer therapies...
  45. ncbi Vimentin function in lymphocyte adhesion and transcellular migration
    Mikko Nieminen
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, P O Box 123, FIN 20521 Turku, Finland
    Nat Cell Biol 8:156-62. 2006
    ..These data show that intermediate filaments are active in lymphocyte adhesion and transmigration...
  46. ncbi Effect of ultrasound contrast agent dose on the duration of focused-ultrasound-induced blood-brain barrier disruption
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, 11221 Taipei, Taiwan
    J Acoust Soc Am 126:3344-9. 2009
    ..This study demonstrates that the appropriate dose of UCA not only enhance the BBB opening but also effectively aid in controlling the duration of BBB disruption...
  47. ncbi Structure-function relationships of PEDF
    T Kawaguchi
    Department of Digestive Disease Information and Research and Department of Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Mol Med 10:302-11. 2010
    ..In addition, since PEDF is recently identified as a regulator for glucose and lipid metabolism, we also discuss PEDF structures specially related to insulin-sensitizing and triglyceridereducing properties...
  48. pmc Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells
    Rachel C Brown
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA
    Brain Res 1130:17-30. 2007
    ....
  49. ncbi Paclitaxel encapsulated in cationic liposomes increases tumor microvessel leakiness and improves therapeutic efficacy in combination with Cisplatin
    Sebastian Strieth
    Department of Otorhinolaryngology, Campus Grosshadern, University of Munich, Munich, Germany
    Clin Cancer Res 14:4603-11. 2008
    ....
  50. ncbi Microvascular fluid exchange and the revised Starling principle
    J Rodney Levick
    Physiology, Basic Medical Sciences, St George s Hospital Medical School, London, UK
    Cardiovasc Res 87:198-210. 2010
    ..Using a two-pore system model, we also explore how relatively small increases in large pore numbers dramatically increase J(v) during acute inflammation...
  51. ncbi siRNA-induced caveolin-1 knockdown in mice increases lung vascular permeability via the junctional pathway
    Kayo Miyawaki-Shimizu
    Dept of Pharmacology, Univ of Illinois College of Medicine, 835 So Wolcott Ave M C868 Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 290:L405-13. 2006
    ..Thus our results demonstrate the essential requirement of caveolin-1 in mediating the formation of caveolae in endothelial cells in vivo and in negatively regulating IEJ permeability...
  52. ncbi Quantitative assessment of the integrity of the blood-retinal barrier in mice
    Nancy L Derevjanik
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Invest Ophthalmol Vis Sci 43:2462-7. 2002
    ..The purpose of this study was to develop and characterize a quantitative assay of blood-retinal barrier (BRB) function in mice and to determine the effect of several purported vasopermeability factors on the BRB...
  53. pmc Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells
    Takashi Koto
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 170:1389-97. 2007
    ..These in vitro and in vivo data indicate that claudin-5 is a target molecule of hypoxia leading to the disruption of the barrier function of neural vasculature...
  54. pmc Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers
    Alejandro P Adam
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 285:7045-55. 2010
    ....
  55. ncbi Tissue engineering: creation of long-lasting blood vessels
    Naoto Koike
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:138-9. 2004
    ..These networks are stable and functional for one year in vivo...
  56. ncbi Significance of blood vessel leakiness in cancer
    Donald M McDonald
    Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Res 62:5381-5. 2002
    ..New research tools such as intravital measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance imaging, and use of selective angiogenesis inhibitors will contribute to this understanding...
  57. ncbi The glomerular endothelial cell coat is essential for glomerular filtration
    Vincent Fridén
    Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    Kidney Int 79:1322-30. 2011
    ..Thus, the absence of one or more of these proteins causes proteinuria and illustrates the importance of the ECC in glomerular permselectivity...
  58. ncbi HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
    Julio C Morote-Garcia
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    Blood 111:5571-80. 2008
    ....
  59. ncbi Vascular permeability in cardiovascular disease and cancer
    Sara M Weis
    Moores UCSD Cancer Center, University of California, San Diego, California 92093 0803, USA
    Curr Opin Hematol 15:243-9. 2008
    ..During cancer, solid tumors release factors that promote the growth of leaky blood vessels which contribute to metastatic spread and limit targeted delivery of anticancer agents...
  60. ncbi Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase
    Xavier Cullere
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 105:1950-5. 2005
    ..Thus, Epac/Rap activation represents a new pathway for regulating endothelial cell barrier function...
  61. ncbi Hydrocortisone reinforces the blood-brain barrier properties in a serum free cell culture system
    D Hoheisel
    Institut fur Biochemie, Westfalische Wilhelms Universitat, Munster, Germany
    Biochem Biophys Res Commun 244:312-6. 1998
    ..2 x 10(-7) cm/s and by a factor of five lower compared to cultures without hydrocortisone and in presence of serum...
  62. pmc CD8 T cell-initiated vascular endothelial growth factor expression promotes central nervous system vascular permeability under neuroinflammatory conditions
    Georgette L Suidan
    Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 184:1031-40. 2010
    ....
  63. pmc Hantavirus infection induces the expression of RANTES and IP-10 without causing increased permeability in human lung microvascular endothelial cells
    J B Sundstrom
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30323, USA
    J Virol 75:6070-85. 2001
    ..These results reveal a possible mechanism by which hantavirus infection and a TH1 immune response can cooperate to synergistically enhance chemokine expression by HMVEC-Ls and trigger immune-mediated increases in vascular permeability...
  64. ncbi An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice
    Jennifer E A Wells
    Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 23:10107-15. 2003
    ..The data indicate that MMP-12 expression after spinal cord trauma is deleterious and contributes to the development of secondary injury in SCI...
  65. pmc Sepsis and pathophysiology of anthrax in a nonhuman primate model
    Deborah J Stearns-Kurosawa
    Department of Free Radical Biology and Aging Research, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Am J Pathol 169:433-44. 2006
    ..This animal model reveals that a fatal outcome is dominated by the host septic response, thereby providing important insights into approaches for treatment and prevention of anthrax in humans...
  66. pmc Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition
    Weiguo Chen
    Sect of Pulmonary and Critical Care Medicine, Pritzker School of Medicine, Univ of Chicago, Chicago, IL 60637
    Am J Physiol Lung Cell Mol Physiol 295:L575-83. 2008
    ....
  67. ncbi Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema
    Hideharu Funatsu
    Department of Ophthalmology, Diabetes Center, Tokyo Women s Medical University, Tokyo, Japan
    Ophthalmology 110:1690-6. 2003
    ..To investigate whether interleukin-6 (IL-6) or vascular endothelial growth factor (VEGF) is related to diabetic macular edema (DME) in subjects without posterior vitreous detachment (PVD)...
  68. pmc Src-family kinase dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins
    Mark R Gillrie
    Department of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Blood 110:3426-35. 2007
    ..These results demonstrate that parasite components can alter endothelial barrier function and thus contribute to the pathogenesis of severe falciparum malaria...
  69. ncbi Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression
    Sho ichi Yamagishi
    Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830 0011, Japan
    J Biol Chem 281:20213-20. 2006
    ..Substitution of PEDF may offer a promising strategy for halting the development of diabetic retinopathy...
  70. ncbi Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice
    Xiao Pei Gao
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Immunol 168:3974-82. 2002
    ....
  71. pmc Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury
    Anne Le
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 105:1282-90. 2008
    ....
  72. ncbi The role of adherens junctions and VE-cadherin in the control of vascular permeability
    Elisabetta Dejana
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Italy
    J Cell Sci 121:2115-22. 2008
    ..We discuss the possible use of inhibitors of SRC and other kinases, of agents that increase cAMP levels, and of inhibitors of lytic enzymes as pharmacological tools for decreasing endothelial permeability...
  73. ncbi Particularities of the vasculature can promote the organ specificity of autoimmune attack
    Bryce A Binstadt
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:284-92. 2006
    ..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders...
  74. ncbi Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through nuclear factor-kappa B pathway activation
    Rohini Polavarapu
    Department of Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 25:10094-100. 2005
    ..We conclude that the cytokine TWEAK plays a role in the disruption of the structure and permeability of the NVU during physiological and pathological conditions...
  75. pmc Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice
    Yehoshua Gozes
    Microbial Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 74:1266-72. 2006
    ..We describe here a ketotifen-sensitive vascular leakage event induced by LT which is the most rapid in vivo or in vitro LT-mediated effect reported to date...
  76. pmc Temporal changes in microvessel leakiness during wound healing discriminated by in vivo fluorescence recovery after photobleaching
    Maria J C Machado
    Centre for Molecular Biosciences, University of Ulster, Cromore Road, Coleraine, Co Londonderry, UK
    J Physiol 589:4681-96. 2011
    ....
  77. ncbi Inhibitory effect of a novel bradykinin B1 receptor antagonist, R-954, on enhanced vascular permeability in type 1 diabetic mice
    Bryan Simard
    Institute of Pharmacology of Sherbrooke, School of Medicine, University of Sherbrooke, Sherbrooke, PQ J1H 5N4, Canada
    Can J Physiol Pharmacol 80:1203-7. 2002
    ..The capillary permeability to albumin was measured by quantifying the extravasation of albumin-bound Evans blue dye in selected ..
  78. ncbi Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin 12 analogue beraprost sodium
    Shinichiro Tanaka
    Department of Microbiology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Drug Target 11:45-52. 2003
    ..These findings establish a new role for BPS, not only in enhancing macromolecular drug delivery, but also in reducing the blood supply to tumor tissues...
  79. pmc Visualizing vascular permeability and lymphatic drainage using labeled serum albumin
    Katrien Vandoorne
    Department of Biological Regulation, Weizmann Institute, Rehovot, 76100, Israel
    Angiogenesis 13:75-85. 2010
    ..This approach was used for monitoring recruitment of perivascular stroma fibroblasts associated with tumor angiogenesis...
  80. ncbi N-acetylcysteine attenuates the acute lung injury caused by phorbol myristate acetate in isolated rat lungs
    I Chun Chuang
    School of Respiratory Care, Kaohsiung Medical University, Kaohsiung, Taiwan
    Pulm Pharmacol Ther 20:726-33. 2007
    ..The mechanisms are possibly attributable to its antioxidant actions, inhibition of pro-inflammatory cytokines, and restoration of glutathione enzymes...
  81. pmc Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury
    Janek Henes
    Department of Anesthesiology and Intensive Care Medicine, Tuebingen University Hospital, Tuebingen, Germany
    FASEB J 23:4244-55. 2009
    ..Taken together these studies identify tissue-specific VASP as a central protein in the control of the alveolar-capillary barrier properties during ALI...
  82. pmc The FGF system has a key role in regulating vascular integrity
    Masahiro Murakami
    Angiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Clin Invest 118:3355-66. 2008
    ..Thus, FGF signaling plays a key role in the maintenance of vascular integrity...
  83. pmc Antipermeability and antiproliferative effects of standard and frozen bevacizumab on choroidal endothelial cells
    Swaantje Peters
    University Eye Hospital, Eberhard Karls University Tuebingen, Schleichstrasse 12, D 72076 Tuebingen, Germany
    Br J Ophthalmol 91:827-31. 2007
    ..Bevacizumab is an antiangiogenic compound developed to target tumour vessels. Its off-label use in ophthalmology requires in vitro testing on ocular cells...
  84. ncbi Inhibition of protein kinase C is not sufficient to prevent or reverse effects of VEGF165 on claudin-1 and permeability in microvascular retinal endothelial cells
    Heidrun L Deissler
    Department of Ophthalmology, University of Ulm Medical School, Ulm, Germany
    Invest Ophthalmol Vis Sci 51:535-42. 2010
    ..This study was conducted to investigate whether the VEGF(165)-induced loss of claudin-1 is regulated by protein kinase C (PKC) and indeed affects the barrier function of iBRECs...
  85. pmc Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/beta-catenin signaling pathway and uPAR expression
    Jinling Yang
    VA Medical Center, Augusta, Georgia, USA
    Invest Ophthalmol Vis Sci 51:3273-80. 2010
    ..The goal of this study was to understand the mechanism by which PEDF blocks VEGF-induced increases in vascular permeability...
  86. ncbi Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
    Ben Bo Gao
    Research Division, Joslin Diabetes Center, One Joslin Place, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 13:181-8. 2007
    ..Inhibition of extracellular CA-I and kallikrein-mediated innate inflammation could provide new therapeutic opportunities for the treatment of hemorrhage-induced retinal and cerebral edema...
  87. pmc Human astrocytes/astrocyte-conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cells
    Venkatraman Siddharthan
    Division of Pediatric Infectious Diseases, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Brain Res 1147:39-50. 2007
    ....
  88. ncbi Acute cerebral vascular injury after subarachnoid hemorrhage and its prevention by administration of a nitric oxide donor
    Fatima A Sehba
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosurg 106:321-9. 2007
    ..In addition, the authors explored whether such alterations were attenuated by administration of a nitric oxide (NO) donor...
  89. ncbi PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging
    Joachim Drevs
    Department of Medical Oncology, Tumor Biology Center, 79106 Freiburg, Germany
    Cancer Res 62:4015-22. 2002
    ..This dilation could influence the result of dyMRI such that no change in extravasation or even an increase in partial tumor blood volume could be observed...
  90. pmc Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
    Rebecca A Stockton
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 207:881-96. 2010
    ....
  91. pmc Luminal platelet aggregates in functional deficits in parenchymal vessels after subarachnoid hemorrhage
    Victor Friedrich
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1354:179-87. 2010
    ....
  92. ncbi Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy
    Kazuhiko Kurozumi
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
    J Natl Cancer Inst 99:1768-81. 2007
    ..We investigated oncolytic virus (OV) therapy-induced changes in tumor blood vessels and the impact of modulating tumor vasculature on the efficacy of oncolytic virus therapy...
  93. ncbi Lung protective ventilatory strategies in acute lung injury and acute respiratory distress syndrome: from experimental findings to clinical application
    Serge J C Verbrugge
    Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Physiol Funct Imaging 27:67-90. 2007
    ..Finally, the clinician is offered directions on lung protective ventilation in the early phase of ARDS which can be applied on the intensive care unit...
  94. pmc Escape of intraluminal platelets into brain parenchyma after subarachnoid hemorrhage
    V Friedrich
    Department of Neuroscience, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY, USA
    Neuroscience 165:968-75. 2010
    ..Three-dimensional analysis suggests that platelet aggregates initiate or stimulate local disruption of endothelium and destruction of adjacent basal lamina after SAH...
  95. ncbi Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability
    Supriya D Mahajan
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Buffalo General Hospital, 301 Multi Research Bldg, 100 High Street, Buffalo, NY 14203, USA
    J Clin Immunol 28:528-41. 2008
    ..These studies may lead to the development of novel anti-HIV-1 therapeutics that target specific TJ proteins, thus preventing TJ disruption in opiate using HIV-1 patients...
  96. ncbi Impact of low pulmonary vascular pressure on ventilator-induced lung injury
    Alain F Broccard
    Division of Intensive Care, Department of Medicine, University Hospital, Lausanne, Switzerland
    Crit Care Med 30:2183-90. 2002
    ..To study the impact of low pulmonary vascular pressure on ventilator-induced lung injury...
  97. ncbi Extravascular lung water to blood volume ratios as measures of pulmonary capillary permeability in nonseptic critically ill patients
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Crit Care 25:16-22. 2010
    ....
  98. ncbi The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats
    Oak Z Chi
    Department of Anesthesia, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901 1977, USA
    Anesth Analg 110:1412-8. 2010
    ..arterioles and capillaries affecting regional cerebral blood flow (rCBF), O(2) supply and consumption, or capillary permeability in focal cerebral ischemia...
  99. ncbi Vascular permeability factor, an endothelial cell mitogen related to PDGF
    P J Keck
    Department of Cell Culture and Biochemistry, Monsanto Company, St Louis, MO 63167
    Science 246:1309-12. 1989
    ..Clusters of basic amino acids in the COOH-terminal halves of human VPF and PDGF-B are also prevalent. Thus, VPF appears to be related to the PDGF/v-sis family of proteins...
  100. pmc Real-time analysis of the kinetics of angiogenesis and vascular permeability in an animal model of wound healing
    Ashkaun Shaterian
    Department of Surgery, University of California, San Diego, CA 92103, USA
    Burns 35:811-7. 2009
    ..We propose a non-invasive strategy to assess VP of the wound capillary bed will facilitate a better understanding of the cell and molecular basis of angiogenesis in wound healing...
  101. ncbi Effect of tumor necrosis factor-alpha on experimental otitis media with effusion
    D H Lee
    Department of Otolaryngology-Head and Neck Surgery College of Medicine, The Catholic University of Korea, Seoul, Korea
    Laryngoscope 111:728-33. 2001
    ....

Research Grants12

  1. PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    Tony Yaksh; Fiscal Year: 1991
    ..a physiologic effect produced by antidromic activation of the somatic afferents, notably an increase in capillary permeability"...
  2. LUNG CAPILLARY PERMEABILITY WITH HIGH VASCULAR PRESSURES
    Mary Townsley; Fiscal Year: 1991
    ..between the capillary filtration coefficient and the osmotic reflection coefficient, which describe the capillary permeability to fluid and proteins respectively, over a wide range of pulmonary microvascular permeabilities, to ..
  3. LIQUID VENTILATION IN ARDS
    Ronald Hirschl; Fiscal Year: 2000
    ..we plan to assess the protective effects of PLV upon acute parameters of lung injury such as pulmonary capillary permeability, degree of intra-alveolar hemorrhage, and level of neutrophil infiltration and the relationship of these ..
  4. Vascular endothelial growth factor induced lung edema
    Robert Kaner; Fiscal Year: 2004
    ..Edema was observed in lung histology and quantified by lung wet-to-dry weight ratio and pulmonary capillary permeability to macromolecules by the Evan's blue dye assay and 131 l-albumin lung leak...
  5. OPTICAL PROBES OF LUNG VASCULAR ENDOTHELIAL FUNCTION
    Thomas Harris; Fiscal Year: 1993
    ..is to develop and test a method for measuring lung circulatory transport properties (pulmonary blood flow, capillary permeability, extravascular lung water) which does not need radioactive tracers...
  6. SALIVARY GLANDS AND THEIR INNERVATION IN DIABETES
    JACOB HANKER; Fiscal Year: 1980
    ..be assessed with various neurohistochemical methods including those which demonstrate axonal transport and capillary permeability. The caries, plaque accumulation periodontal changes and changes observed in the tongue of the diabetic ..
  7. XOR Regulation of Endothelial Cell Apoptosis in the Model of VALI
    BO SOO KIM; Fiscal Year: 2010
    ..and promotes apoptosis of alveolar endothelial and epithelial cells resulting in increases in alveolar capillary permeability. We have shown that pharmacologic inhibition of XOR with allopurinol abrogates HVT- induced increase in ..
  8. PATHOPHYSIOLOGY OF EXTRACELLULAR MATRIX
    Gary Rosenberg; Fiscal Year: 2000
    ..Temporary middle cerebral artery occlusion (MCAO) causes a biphasic increase in capillary permeability, which may be related to the inflammatory release of MMPs and uPA...
  9. HAMSTER: A MODEL FOR PROGESTERONE-DEPENDENT IMPLANTATION
    BIBHASH PARIA; Fiscal Year: 2002
    ..However, hamsters share some common features of implantation, such as increased capillary permeability and stromal decidualization at the site of implantation...
  10. MOLECULAR BASIS OF CAPILLARY PERMEABILITY
    Jan Schnitzer; Fiscal Year: 2004
    ..of this project is to define the molecular and cellular basis of the barriers and pathways that mediate capillary permeability. The ability of the endothelium to act both as a restrictive barrier to transvascular exchange and as a ..
  11. MICRORHEOLOGIC MECHANISMS IN VASCULAR PATHOPHYSIOLOGY
    SALVATORE SUTERA; Fiscal Year: 1992
    ..iii) to test the hypotheses that impaired red cell deformability in vivo (a) can induce increased capillary permeability and (b) leads to red cell sequestration in the spleen and other organs; (iv) to define the sensitivity of ..
  12. The Glycocalyx and Endothelial Barrier Regulation
    RANDAL DULL; Fiscal Year: 2005
    ..synthetic colloids could be developed that exploit cell-surface glycoprotein binding in order to normalize capillary permeability. This K08 will provide the foundation for a research career dedicated to understanding the molecular ..