Summary: The sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosysthesis) and catabolism; the buildup and breakdown of molecules for utilization by the body.

Top Publications

  1. pmc Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
  2. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
  3. pmc The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    Charles E Massie
    CRUK Cambridge Research Institute, Cambridge, UK
    EMBO J 30:2719-33. 2011
  4. pmc Analysis of omics data with genome-scale models of metabolism
    Daniel R Hyduke
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Mol Biosyst 9:167-74. 2013
  5. ncbi Network biology: understanding the cell's functional organization
    Albert Laszlo Barabasi
    Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Nat Rev Genet 5:101-13. 2004
  6. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
  7. pmc Influence of metabolism on epigenetics and disease
    William G Kaelin
    Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Cell 153:56-69. 2013
  8. pmc Reactome: a knowledgebase of biological pathways
    G Joshi-Tope
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    Nucleic Acids Res 33:D428-32. 2005
  9. doi The nexus of chromatin regulation and intermediary metabolism
    Philipp Gut
    Gladstone Institutes, University of California, San Francisco, California 94941, USA
    Nature 502:489-98. 2013
  10. ncbi Myocardial substrate metabolism in the normal and failing heart
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    Physiol Rev 85:1093-129. 2005

Detail Information

Publications360 found, 100 shown here

  1. pmc Autophagy and metabolism
    Joshua D Rabinowitz
    Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Science 330:1344-8. 2010
    ..The resulting breakdown products are inputs to cellular metabolism, through which they are used to generate energy and to build new proteins and membranes...
  2. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
    ..Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions...
  3. pmc The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    Charles E Massie
    CRUK Cambridge Research Institute, Cambridge, UK
    EMBO J 30:2719-33. 2011
    ..cancer and regulates cancer cell growth via its unexpected role as a hormone-dependent modulator of anabolic metabolism. In conclusion, it is possible to progress from transcriptional studies to a promising therapeutic target by ..
  4. pmc Analysis of omics data with genome-scale models of metabolism
    Daniel R Hyduke
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Mol Biosyst 9:167-74. 2013
    ..This improvement is largely due to knowledge bases providing a validated biological context for interpreting the data...
  5. ncbi Network biology: understanding the cell's functional organization
    Albert Laszlo Barabasi
    Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Nat Rev Genet 5:101-13. 2004
  6. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
    ..More generally, the model predicts structural and functional properties of vertebrate cardiovascular and respiratory systems, plant vascular systems, insect tracheal tubes, and other distribution networks...
  7. pmc Influence of metabolism on epigenetics and disease
    William G Kaelin
    Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Cell 153:56-69. 2013
    ..remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metabolism. This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, ..
  8. pmc Reactome: a knowledgebase of biological pathways
    G Joshi-Tope
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    Nucleic Acids Res 33:D428-32. 2005
    ..model allows us to represent many diverse processes in the human system, including the pathways of intermediary metabolism, regulatory pathways, and signal transduction, and high-level processes, such as the cell cycle...
  9. doi The nexus of chromatin regulation and intermediary metabolism
    Philipp Gut
    Gladstone Institutes, University of California, San Francisco, California 94941, USA
    Nature 502:489-98. 2013
    ..Numerous connections between products of intermediary metabolism and chromatin proteins have recently been identified...
  10. ncbi Myocardial substrate metabolism in the normal and failing heart
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    Physiol Rev 85:1093-129. 2005
    The alterations in myocardial energy substrate metabolism that occur in heart failure, and the causes and consequences of these abnormalities, are poorly understood...
  11. ncbi The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
    M Hucka
    Control and Dynamical Systems, MC 107 81, California Institute of Technology, Pasadena, CA 91125, USA
    Bioinformatics 19:524-31. 2003
    ..Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively...
  12. pmc HMDB: the Human Metabolome Database
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 35:D521-6. 2007
    ..HMDB) is currently the most complete and comprehensive curated collection of human metabolite and human metabolism data in the world...
  13. ncbi Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies
    Olivier Cloarec
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK
    Anal Chem 77:517-26. 2005
  14. ncbi Hierarchical organization of modularity in metabolic networks
    E Ravasz
    Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA
    Science 297:1551-5. 2002
    ..Within Escherichia coli, the uncovered hierarchical modularity closely overlaps with known metabolic functions. The identified network architecture may be generic to system-level cellular organization...
  15. pmc Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood
    Elinor L Sullivan
    Department of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neuroendocrinology 93:1-8. 2011
    ..The perinatal environment plays an important role in programming many aspects of physiology and behavior including metabolism, body weight set point, energy balance regulation and predisposition to mental health-related disorders such as ..
  16. pmc Global reconstruction of the human metabolic network based on genomic and bibliomic data
    Natalie C Duarte
    Bioengineering Department, University of California at San Diego, La Jolla, CA 92093 0412, USA
    Proc Natl Acad Sci U S A 104:1777-82. 2007
    b>Metabolism is a vital cellular process, and its malfunction is a major contributor to human disease...
  17. pmc Dynamic flux balance analysis of diauxic growth in Escherichia coli
    Radhakrishnan Mahadevan
    Department of Chemical Engineering, University of Delaware, Newark, Delaware 19716 USA
    Biophys J 83:1331-40. 2002
    ..Therefore, dynamic FBA provides a framework for analyzing the transience of metabolism due to metabolic reprogramming and for obtaining insights for the design of metabolic networks.
  18. pmc A role for gene duplication and natural variation of gene expression in the evolution of metabolism
    Daniel J Kliebenstein
    Department of Plant Sciences, University of California Davis, Davis, California, United States of America
    PLoS ONE 3:e1838. 2008
    ..Finally, the ability of gene duplicates to diverge may be limited by their biological function...
  19. pmc The KEGG databases at GenomeNet
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 30:42-6. 2002
    ..The KEGG databases are updated daily and made freely available (
  20. pmc Integrating cellular metabolism into a multiscale whole-body model
    Markus Krauss
    Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany
    PLoS Comput Biol 8:e1002750. 2012
    Cellular metabolism continuously processes an enormous range of external compounds into endogenous metabolites and is as such a key element in human physiology...
  21. doi FGFs and metabolism
    Alexei Kharitonenkov
    Eli Lilly and Company, Lilly Research Laboratories, Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Curr Opin Pharmacol 9:805-10. 2009
    ..morphogenesis, angiogenesis, hematopoiesis, and survival, this decade provided clues on FGF roles in metabolism. In particular, 'hormone-like' FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, ..
  22. doi The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
    Clin Biochem 43:732-44. 2010
    ..Its metabolism methylates homocysteine to methionine, also producing N,N-dimethylglycine...
  23. pmc Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial
    Carolien A Wijsman
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands
    J Med Internet Res 15:e233. 2013
    Lack of physical activity leads to detrimental changes in body composition and metabolism, functional decline, and increased risk of disease in old age...
  24. pmc Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia
    David Leitsch
    Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
    J Antimicrob Chemother 66:1756-65. 2011
    ..Resistance to metronidazole has been associated with down-regulation of PFOR and Fd. The aim of this study was to determine whether the PFOR/Fd couple is the only pathway involved in metronidazole activation in Giardia...
  25. ncbi Metabolic rate and body temperature reduction during hibernation and daily torpor
    Fritz Geiser
    Zoology, Center for Behavioural and Physiological Ecology, University of New England, Armidale, NSW Australia 2351
    Annu Rev Physiol 66:239-74. 2004
    ..However, conductance is low when deeply torpid animals are thermo-conforming probably because of peripheral vasoconstriction...
  26. doi Genome-scale modeling of human metabolism - a systems biology approach
    Adil Mardinoglu
    Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
    Biotechnol J 8:985-96. 2013
    Altered metabolism is linked to the appearance of various human diseases and a better understanding of disease-associated metabolic changes may lead to the identification of novel prognostic biomarkers and the development of new therapies...
  27. doi CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism
    Blake C Ellis
    CSIRO Animal, Food and Health Sciences, Preventative Health Flagship, Commonwealth Scientific and Industrial Research Organization, Sydney, NSW 2113 Australia Electronic address
    Biochim Biophys Acta 1843:372-86. 2014
    ..showed correlation with insulin/IGF signaling pathway components and responses, including glucose and lipid metabolism. Some of the genes are identical to those affected by insulin treatment in the same cell line...
  28. ncbi Programming of intermediary metabolism
    C J Petry
    Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 2QR, UK
    Mol Cell Endocrinol 185:81-91. 2001
    ..Alterations in intermediary metabolism were noted in the rats with early growth restriction, which provide support for our hypothesis and clues to the ..
  29. ncbi Metabolic profiling technologies for biomarker discovery in biomedicine and drug development
    Götz Schlotterbeck
    F Hoffmann La Roche Ltd, Pharmaceuticals Division, PRBD E, CH 4070 Basel, Switzerland
    Pharmacogenomics 7:1055-75. 2006
    ..The complexity of disease and drug treatment is asking for an adequate response by integrated and comprehensive metabolite profiling approaches that allow the discovery of new combinations of metabolic biomarkers...
  30. pmc The ability of flux balance analysis to predict evolution of central metabolism scales with the initial distance to the optimum
    William R Harcombe
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 9:e1003091. 2013
    The most powerful genome-scale framework to model metabolism, flux balance analysis (FBA), is an evolutionary optimality model...
  31. pmc Expansion of the BioCyc collection of pathway/genome databases to 160 genomes
    Peter D Karp
    Bioinformatics Research Group, SRI International EK207, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Nucleic Acids Res 33:6083-9. 2005
    ..Only by harnessing the expertise of many scientists we can hope to produce biological databases, which accurately reflect the depth and breadth of knowledge that the biomedical research community is producing...
  32. pmc Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
    Robert Schuetz
    Institute of Molecular Systems Biology, ETH Zurich, Switzerland
    Mol Syst Biol 3:119. 2007
  33. doi Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1
    Yuichi Nishi
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem J 435:421-30. 2011
    ..We evaluated the role of PiC in metabolism-secretion coupling in pancreatic β-cells using INS-1 cells manipulated to reduce PiC expression by siRNA (small ..
  34. ncbi Evolution of the protein repertoire
    Cyrus Chothia
    Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 300:1701-3. 2003
    ..Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes...
  35. doi Epigenetics and metabolism in 2011: Epigenetics, the life-course and metabolic disease
    Peter D Gluckman
    Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Nat Rev Endocrinol 8:74-6. 2012
    ..Data published in 2011 suggest that epigenetic analysis could potentially have utility as a marker of early metabolic pathology and might enable early life prophylaxis...
  36. ncbi A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum
    Uly Nasution
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Metab Eng 10:10-23. 2008
    The relation between central metabolism and the penicillin biosynthesis pathway in Penicillium chrysogenum was studied by manipulating the steady-state flux in both pathways...
  37. ncbi Metabolite profiling for plant functional genomics
    O Fiehn
    Max Planck Institute of Molecular Plant Physiology, 14424 Potsdam, Germany
    Nat Biotechnol 18:1157-61. 2000
    ..These results demonstrate the use of metabolite profiling as a tool to significantly extend and enhance the power of existing functional genomics approaches...
  38. doi Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI)
    Ravi Kumar Sangeetha
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, CSIR, Mysore, 570 020, India
    Mol Cell Biochem 333:299-310. 2010
    This study reports bioavailability and metabolism of fucoxanthin (FUCO) from brown algae Padina tetrastromatica in rats. Rats were divided into two groups (n = 25/group)...
  39. ncbi Size and form in efficient transportation networks
    J R Banavar
    Department of Physics and Center for Materials Physics, The Pennsylvania State University, University Park 16802, USA
    Nature 399:130-2. 1999
    Many biological processes, from cellular metabolism to population dynamics, are characterized by allometric scaling (power-law) relationships between size and rate...
  40. ncbi Regulation of growth and metabolism by imprinted genes
    F M Smith
    Centre for Regenerative Medicine and Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath, UK
    Cytogenet Genome Res 113:279-91. 2006 influence energy homeostasis and some, including Igf2 and Grb10, may coordinate growth with glucose-regulated metabolism. Since perturbation of fetal growth can be correlated with metabolic disorders in adulthood these imprinted ..
  41. pmc Coral larvae under ocean acidification: survival, metabolism, and metamorphosis
    Masako Nakamura
    Sesoko Station, Tropical Biosphere Research Center, University of the Ryukyus, Okinawa, Japan
    PLoS ONE 6:e14521. 2011
    ..These results imply that acidified seawater impacts larval physiology, suggesting that suppressed metabolism and metamorphosis may alter the dispersal potential of larvae and subsequently reduce the resilience of coral ..
  42. ncbi Diet, metabolism and lifespan in Drosophila
    Matthew D W Piper
    UCL Centre for Research on Ageing, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Gerontol 40:857-62. 2005
    ..Current data indicate lifespan-extension by DR is likely to involve both enhancement of various defense and detoxification mechanisms and a complex range of metabolic alterations that make energy available for these processes...
  43. doi Internal desynchronization in a model of night-work by forced activity in rats
    R Salgado-Delgado
    Departamento de Anatomia, Facultad de Medicina, Edificio B 4 Piso, Universidad Nacional Autonoma de Mexico, Mexico DF 04510, Mexico
    Neuroscience 154:922-31. 2008
    ..The present data suggest that in the night worker the combination of work and eating during working hours may be the cause of internal desynchronization...
  44. ncbi From measurements of metabolites to metabolomics: an 'on the fly' perspective illustrated by recent studies of carbon-nitrogen interactions
    Mark Stitt
    Departments of Metabolic Networks and Molecular Physiology, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476, Golm, Germany
    Curr Opin Biotechnol 14:136-44. 2003
    ..A major future challenge concerns the integration of the information gained from metabolite profiling into an accessible body of knowledge...
  45. pmc Pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 248:387-401. 2008
    ..To improve clinical outcome and to determine new treatment options, we studied the pathophysiologic response postburn in a large prospective, single center, clinical trial...
  46. ncbi Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    John C Lindon
    Biological Chemistry, Biomedical Sciences, Division, Faculty of Medicine, Imperial College London, UK
    Biomarkers 9:1-31. 2004, metabonomics, a combination of data-rich analytical chemical measurements and chemometrics for profiling metabolism in complex systems, is described and its applications are reviewed...
  47. ncbi 13C metabolic flux analysis
    W Wiechert
    Department of Simulation, IMR, University of Siegen, Paul Bonatz Strasse 9 11, D 57068 Siegen, Germany
    Metab Eng 3:195-206. 2001
    ..It allows the detailed quantification of all intracellular fluxes in the central metabolism of a microorganism...
  48. pmc Computational prediction of human metabolic pathways from the complete human genome
    Pedro Romero
    Bioinformatics Research Group, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Genome Biol 6:R2. 2005
    ..Pathway assignments place genes in their larger biological context, and are a necessary first step toward quantitative modeling of metabolism.
  49. doi Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences
    Nicholas A Burd
    Exercise Metabolism Research Group, Dept of Kinesiology, McMaster Univ, 1280 Main St, West Hamilton, ON, Canada L8S 4K1
    J Appl Physiol (1985) 106:1692-701. 2009
    ..Furthermore, we examine the underlying anabolic signaling pathways and molecules that regulate these processes...
  50. doi Effects of olanzapine and haloperidol on the metabolic status of healthy men
    Solrun Vidarsdottir
    Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 95:118-25. 2010
    ..The aim of this study was to determine the effect of short-term olanzapine (atypical antipsychotic drug) and haloperidol (conventional antipsychotic drug) treatment on glucose and lipid metabolism.
  51. ncbi Practical markers of the transition from aerobic to anaerobic metabolism during exercise: rationale and a case for affect-based exercise prescription
    Panteleimon Ekkekakis
    Department of Health and Human Performance, Iowa State University, 235 Barbara E Forker Building, Ames, IA 50011, USA
    Prev Med 38:149-59. 2004
    ..The point of transition from aerobic to anaerobic metabolism may be an appropriate level of exercise training intensity as it appears to be effective and safe for a variety ..
  52. ncbi Fluoranthene metabolism and associated proteins in Mycobacterium sp. JS14
    Sung Eun Lee
    Department of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI 9682, USA
    Proteomics 7:2059-69. 2007
    ..A fluoranthene degradation pathway for Mycobacterium sp. JS14 was proposed and confirmed by proteomic study by identifying almost all the enzymes required during the initial steps of fluoranthene degradation...
  53. pmc Choline metabolism and risk of breast cancer in a population-based study
    Xinran Xu
    Department of Community and Preventive Medicine, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    FASEB J 22:2045-52. 2008
    Choline is an essential nutrient required for methyl group metabolism, but its role in carcinogenesis and tumor progression is not well understood...
  54. doi The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism
    Lihua Jin
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian 361005, China
    Nat Commun 4:1937. 2013
    ..mice, with ivermectin decreases serum glucose and cholesterol levels, suggesting that ivermectin regulates metabolism through FXR...
  55. pmc Temporal expression-based analysis of metabolism
    Sara B Collins
    Program in Bioinformatics, Boston University, Boston, Massachusetts, United States of America
    PLoS Comput Biol 8:e1002781. 2012
    Metabolic flux is frequently rerouted through cellular metabolism in response to dynamic changes in the intra- and extra-cellular environment...
  56. doi Sirtuins, aging, and metabolism
    Leonard Guarente
    Paul F Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cold Spring Harb Symp Quant Biol 76:81-90. 2011
    ..Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging...
  57. ncbi MicroRNAs: a new class of regulatory genes affecting metabolism
    Jan Krutzfeldt
    Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Cell Metab 4:9-12. 2006
    ..These studies open the possibility that miRNAs may contribute to common metabolic diseases and point to novel therapeutic opportunities based on targeting of miRNAs...
  58. doi Relevance of the MEK/ERK signaling pathway in the metabolism of activated macrophages: a metabolomic approach
    Paqui G Traves
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28029 Madrid, Spain
    J Immunol 188:1402-10. 2012
    ..We concluded that inhibition of the MEK/ERK cascade interferes with central metabolism, and this cross-talk between signal transduction and metabolism also occurs in the presence of LPS.
  59. doi At the crossroad between immunity and metabolism: focus on leptin
    Javier Conde
    Research laboratory 9 NEIRID LAB Neuroendocrine Interactions in Rheumatology and Inflammation Disease, Building C, Level 2, Institute of Medical Research IDIS, Santiago University Clinical Hospital, Calle Choupana s n, Santiago de Compostela, 15706, Spain
    Expert Rev Clin Immunol 6:801-8. 2010
    ..most important adipokines secreted by fat cells, with a variety of physiological roles related to the control of metabolism, energy homeostasis and inflammatory response...
  60. pmc Quantitative imaging of subcellular metabolism with stable isotopes and multi-isotope imaging mass spectrometry
    Matthew L Steinhauser
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States Division of Genetics, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, United States Division of Cardiovascular Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, United States
    Semin Cell Dev Biol 24:661-7. 2013
    ..Here we review the basic elements of MIMS and describe new applications of MIMS to the quantitative study of metabolic processes including protein and nucleic acid synthesis in model organisms ranging from microbes to humans. ..
  61. doi The thyroid and metabolism: the action continues
    Anthony N Hollenberg
    Division of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 8:10-2. 2008
    On March 27, 2008, the American Thyroid Association sponsored a research summit on the Thyroid and Metabolism. The goals of the summit were to explore emerging new concepts and potential therapies arising from recent insights into the ..
  62. doi Qualitative and quantitative analysis of tumor cell metabolism via stable isotope labeling assisted microfluidic chip electrospray ionization mass spectrometry
    Qiushui Chen
    Beijing Key Laboratory of Analytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, People s Republic of China
    Anal Chem 84:1695-701. 2012
    ..ionization mass spectrometry (SIL-chip-ESI-MS) platform for qualitative and quantitative analysis of cell metabolism was developed...
  63. ncbi Effect of fat adaptation and carbohydrate restoration on metabolism and performance during prolonged cycling
    L M Burke
    Sports Science and Sports Medicine, Australian Institute of Sport, Belconnen 2616, Australia
    J Appl Physiol (1985) 89:2413-21. 2000
    ..However, there was no evidence of a clear benefit of fat adaptation to cycling performance...
  64. doi Conserved metabolic regulatory functions of sirtuins
    Bjoern Schwer
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Cell Metab 7:104-12. 2008
    ..The earliest function of sirtuins therefore may have been regulation of cellular metabolism in response to nutrient availability...
  65. doi The time of metabolism: NAD+, SIRT1, and the circadian clock
    M M Bellet
    Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Cold Spring Harb Symp Quant Biol 76:31-8. 2011
  66. pmc Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases
    Fayez K Ghishan
    Dept of Pediatrics, Steele Children s Research Center, Univ of Arizona Health Sciences Center 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 300:G191-201. 2011
    Chronic inflammatory disorders such as inflammatory bowel diseases (IBDs) affect bone metabolism and are frequently associated with the presence of osteopenia, osteoporosis, and increased risk of fractures...
  67. pmc Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption
    Jana Husse
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    PLoS ONE 7:e52983. 2012
  68. ncbi Metabolism of 14C-labelled and non-labelled sulfadiazine after administration to pigs
    Marc Lamshöft
    Institute of Environmental Research INFU, University of Dortmund, Otto Hahn Strasse 6, 44221, Dortmund, Germany
    Anal Bioanal Chem 388:1733-45. 2007
    ..5 to 10,000 microg kg(-1) manure with a correlation coefficient>or=0.99. The same experiment was carried out simultaneously with non-labelled SDZ to obtain manure for outdoor soil experiments...
  69. ncbi Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering
    S Schuster
    Department of Bioinformatics, Max Delbruck Centre for Molecular Medicine, Berlin Buch, Germany
    Trends Biotechnol 17:53-60. 1999
    ..This approach can be used for many biotechnological applications such as increasing the yield of a product, channelling a product into desired pathways and in functional reconstruction from genomic data...
  70. pmc The hypocretins as sensors for metabolism and arousal
    Antoine Adamantidis
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5742, USA
    J Physiol 587:33-40. 2009
    ..Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions...
  71. ncbi Genome-scale microbial in silico models: the constraints-based approach
    Nathan D Price
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 2093 0412, USA
    Trends Biotechnol 21:162-9. 2003
    ..These results are useful as a basis for iterative model building and for several practical applications...
  72. ncbi Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response
    Valerio Gozzoli
    Surgical Intensive Care Division, University Hospital of Geneva, 1211 Geneva 14, Switzerland
    Intensive Care Med 30:401-7. 2004
    ..We investigated the metabolic, hemodynamic, and inflammatory responses of pharmacological and physical therapies aimed at reducing body temperature in febrile critically ill patients...
  73. doi NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology
    Muireann Coen
    Department of Biomolecular Medicine, Surgery, Oncology, Reproductive Biology and Anesthetics Division, Faculty of Medicine, Imperial College London, London, UK
    Chem Res Toxicol 21:9-27. 2008
    ..The use of biological fluids as a source of whole organism metabolic information enhances the use of this approach in minimally invasive longitudinal studies...
  74. pmc Metabolism strikes back: metabolic flux regulates cell signaling
    Christian M Metallo
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 24:2717-22. 2010
    ..This mechanism ensures that cells do not engage in anabolic metabolism when nutrients are limiting, and highlights how substrate availability for protein modifications can modulate ..
  75. ncbi Bow ties, metabolism and disease
    Marie Csete
    Emory Anesthiology Research Labs, 1462 Clifton Rd NE, Room 420, Atlanta GA 30322, USA
    Trends Biotechnol 22:446-50. 2004
    ..Large-scale organizational frameworks such as the bow tie are necessary starting points for higher-resolution modeling of complex biologic processes..
  76. doi Diabetes and protein metabolism
    Niels Møller
    Medical Department M, Aarhus University Hospital, Medical Research Laboratories, Aarhus C 8000, Denmark
    Diabetes 57:3-4. 2008
  77. ncbi H2S induced hypometabolism in mice is missing in sedated sheep
    Philippe Haouzi
    Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States
    Respir Physiol Neurobiol 160:109-15. 2008
    ..We measured metabolism in conscious mice (24 g) exposed to H(2)S (60 ppm) at an ambient temperature of 23-24 degrees C...
  78. ncbi Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene expression
    Weiling Zhao
    Department of Radiation Oncology, Brain Tumor Center of Wake Forest University, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Clin Cancer Res 12:3823-30. 2006
    ..As such, the aim of the present study was to identify candidate genes involved in the development of radiation injury in the murine kidney and brain using microarray analysis...
  79. doi PPARdelta/beta: the lobbyist switching macrophage allegiance in favor of metabolism
    Beatrice Desvergne
    Center of Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Cell Metab 7:467-9. 2008
    ..In two studies by Kang et al. (2008) and Odegaard et al. (2008) in this issue of Cell Metabolism, we learn that alternative activation (M2a) of resident macrophages in liver and adipose tissue depends highly ..
  80. doi Bone and metabolism: a complex crosstalk
    Liesbet Lieben
    Laboratory for Experimental Medicine and Endocrinology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Horm Res 71:134-8. 2009
    Until recently, communication from metabolism to bone was considered purely unidirectional, involving complex interactions among an adipocyte-derived factor (leptin), the sympathetic nervous system and neuropeptides...
  81. pmc Hypothalamic sites of leptin action linking metabolism and reproduction
    Jose Donato
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9077, USA
    Neuroendocrinology 93:9-18. 2011
    ..In this review, we discuss the recent advances in the field focused on the identification of potential site(s) or specific neuronal populations involved in leptin's effects in the neuroendocrine reproductive axis...
  82. ncbi Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospectus
    Jeevan K Prasain
    Department of Pharmacology and Toxicology, Purdue UAB Botanicals Center for Age Related Disease, UAB Center for Nutrient Gene Interaction in Cancer Prevention, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Pharm 4:846-64. 2007
    ..behavior of these compounds following oral ingestion is needed as well as their absorption, distribution, metabolism, and excretion (ADME)...
  83. ncbi Organizational invariance and metabolic closure: analysis in terms of (M,R) systems
    Juan Carlos Letelier
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    J Theor Biol 238:949-61. 2006
    ..formulation of (M,R) systems in terms of mappings and sets of mappings, which is grounded in the metaphor of metabolism as a mathematical mapping...
  84. pmc Transplantation of adipose tissue and stem cells: role in metabolism and disease
    Thien T Tran
    Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    Nat Rev Endocrinol 6:195-213. 2010
    ..metabolic effects, subcutaneous white adipose tissue and brown adipose tissue have the potential to benefit metabolism by improving glucose homeostasis and increasing energy consumption...
  85. doi The circadian clock and metabolism
    Oren Froy
    Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    Clin Sci (Lond) 120:65-72. 2011
    ..and physiological functions in addition to the expression and/or activity of enzymes and hormones involved in metabolism. In turn, key metabolic enzymes and transcription activators interact with and affect the core clock mechanism...
  86. ncbi Adenine nucleotide metabolism in human blood--important roles for leukocytes and erythrocytes
    S Heptinstall
    Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research, University of Nottingham, UK
    J Thromb Haemost 3:2331-9. 2005
    ..Rapid metabolism of ADP and ATP by endothelial cells is important in protecting platelets from their effects...
  87. ncbi A salvage pathway for phytol metabolism in Arabidopsis
    Till Ischebeck
    Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    J Biol Chem 281:2470-7. 2006
    ..Thus, Arabidopsis contains a distinct enzymatic machinery for redirecting free phytol released from chlorophyll degradation into chloroplast lipid metabolism.
  88. pmc A network perspective on metabolism and aging
    Quinlyn A Soltow
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Integr Comp Biol 50:844-54. 2010
    ..Here, we advocate the use of metabolic networks to expand the work from genomics and proteomics. As metabolism is the final fingerprint of functionality and has been implicated in multiple theories of aging, metabolomic ..
  89. ncbi Transcriptional regulation of metabolism
    Beatrice Desvergne
    Center for Integrative Genomics, National Centre of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    Physiol Rev 86:465-514. 2006
    Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made towards elucidating the mechanisms controlling the major regulatory pathways are now being rewarded...
  90. ncbi Targeted profiling: quantitative analysis of 1H NMR metabolomics data
    Aalim M Weljie
    Chenomx Inc, Edmonton, Alberta, Canada, and Metabolomics Research Centre, University of Calgary, Calgary, Canada
    Anal Chem 78:4430-42. 2006
    ..mixtures is an area of active research in the emerging field of "metabolomics", which combines metabolism, spectroscopy, and multivariate statistical analysis (pattern recognition) methods...
  91. pmc CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Sci Signal 2:re3. 2009
    ..Identification of the precise CD36 signaling pathways in specific cells elicited in response to specific ligands may yield novel targets for drug development...
  92. ncbi MicroRNA control of lifespan and metabolism
    Michelle Boehm
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA
    Cell Cycle 5:837-40. 2006
    ..regulators will undoubtedly further our understanding of the complex genetic networks that control lifespan and metabolism, and will also provide us with novel targets for the therapeutic intervention of metabolic and age-related ..
  93. ncbi Theodor Bücher Lecture. Metabolomics, modelling and machine learning in systems biology - towards an understanding of the languages of cells. Delivered on 3 July 2005 at the 30th FEBS Congress and the 9th IUBMB conference in Budapest
    Douglas B Kell
    School of Chemistry, Faraday Building, The University of Manchester, UK
    FEBS J 273:873-94. 2006
    ..These include fields such as chemical genomics, synthetic biology, distributed computational environments for biological data and modelling, single cell diagnostics/bionanotechnology, and computational linguistics/text mining...
  94. ncbi Chemometrics in metabonomics
    Johan Trygg
    Research Group for Chemometrics, Institute of Chemistry, Umea University, Sweden
    J Proteome Res 6:469-79. 2007
    ..This is illustrated by examples from the literature...
  95. doi Metabolomics: a global biochemical approach to drug response and disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Annu Rev Pharmacol Toxicol 48:653-83. 2008
    Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science...
  96. pmc From sirtuin biology to human diseases: an update
    Carlos Sebastian
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 287:42444-52. 2012
    ..In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas...
  97. pmc A novel two-component system involved in the transition to secondary metabolism in Streptomyces coelicolor
    Daniel Rozas
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    PLoS ONE 7:e31760. 2012
    ..Therefore, this two-component system in S. coelicolor seems to influence various processes characterised by the transition from primary to secondary metabolism, as determined by proteomic and transcriptomic analyses.
  98. ncbi Metabolomics by numbers: acquiring and understanding global metabolite data
    Royston Goodacre
    Department of Chemistry, UMIST, P O Box 88, Sackville Street, Manchester M60 1QD, UK
    Trends Biotechnol 22:245-52. 2004
  99. ncbi Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals
    Serge Rezzi
    BioAnalytical Science, Metabonomics and Biomarkers, Nestle Research Center, P O Box 44, CH 1000 Lausanne 26, Switzerland
    J Proteome Res 6:4469-77. 2007
    ..measured using 1H NMR spectroscopy, including the postprandial lipoprotein profile and gut microbial co-metabolism. These data suggest that specific dietary preferences can influence basal metabolic state and gut microbiome ..
  100. pmc The evolution of connectivity in metabolic networks
    Thomas Pfeiffer
    Computational Laboratory, ETH Zurich, Zurich, Switzerland
    PLoS Biol 3:e228. 2005
    ..Specifically, our simulations indicate that group transfer reactions are essential for the emergence of hubs...
  101. ncbi Altered body composition and metabolism in the male offspring of high fat-fed rats
    Alexandra J Buckley
    School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia
    Metabolism 54:500-7. 2005
    ..fat can modify the programming of an offspring's glucose tolerance, insulin sensitivity, body composition, lipid metabolism, and insulin signaling...

Research Grants71

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  4. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..overload, heart disease, liver disease, endocrine dysfunction, nutritional deficiencies and disorders of bone metabolism. Our future goals include expanded screening for cardiac iron deposition using newly available MRI technology ..
  5. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..of human immune response genes using ~200,000 SNPs 2) A panel of ~ 200,000 SNPs covering the genes in human metabolism. 3) A [unreadable]genotyping[unreadable] platform capable of measuring DNA methylation in human samples using ..
  6. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..ranging from production and secretion of proteins such as albumin, clotting factors and antiproteases, to metabolism and excretion of exogenous compounds such as drugs or toxins as well as endogenous compounds like hormones, ..
  7. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..These changes may be due to direct ovarian effects on lipoprotein metabolism, and/or steroids secreted from the ovary having systemic effects on the liver or other organs...
  8. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..generation of GSH and the MTh flavonolignans are inducers of many cellular enzymes participating in GSH metabolism, including GSH-reductase (GSH-R), GSH-peroxidase (GSH-Px), GSH-S-transferases (GST) and superoxide dismutase (..
  9. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..standardized measures of vascular endothelial function, biomarkers of oxidant stress, modulators of nitric oxide metabolism and iron loading is critical for the understanding of sickle vasculopathy and must be accomplished before an ..
  10. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..eCB/CB1 receptor signaling is involved in the regulation of food consumption and metabolism via multiple mechanisms: it regulates the rewarding properties of food via effects on central mesolimbic ..
  11. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..maintenance of body weight are regulated by a concerted action of sensing peripheral nutrient status and energy metabolism to the brain which integrates the signals with central inputs of circadian rhythm and psychological stressors...
  12. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..Aim 2: We investigate the physiological requirement for PRDI\/I16 in BAT and whole body metabolism by creating and characterizing tissue-specific PRD/Wt6-deficient mice...
  13. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    ..a bone- derived hormone implicated in the pathogenesis of many human diseases including disorders of mineral metabolism and chronic kidney disease...
  14. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..g. reduced MW, LogP) and would provide one dimensional metabolism, pharmacokinetics, and safety profiles as opposed to co-administering two drugs where development metrics are ..
  15. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..Alterations in lysophospholipid metabolism and signaling also contribute to drug and radiation resistance, tumor angiogenesis, and progression of many ..
  16. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..So far, not a single study has examined the effects of CPAP on glucose metabolism specifically in prediabetes, a potentially reversible state in which the development of overt diabetes and its ..
  17. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..neuropeptide Y through the central thyroid axis and the melanocortin 4 receptor through hepatic thyroid hormone metabolism resulted in a 1st-author publication in Cell Metabolism...
  18. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Of particular interest are adaptive changes in proteins associated with metabolism, oxidative stress, and cell death...
  19. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..TRT on body composition (muscle CSA, VAT, %FM) and the metabolic profiles (glucose and lipid metabolism) in individuals with motor complete SCI...
    Patrice G Guyenet; Fiscal Year: 2013
    ..stresses such as infection, hypotension, pain and hypoxia and they also contribute to the regulation of glucose metabolism. Collectively, these data suggest that the C1 cells mediate neuroendocrine responses (sympathoadrenal activation,..
  21. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012 the principle biological methyl donor that is made in all mammalian cells as the first product of methionine metabolism, catalyzed by methionine adenosylmethionine (MAT)...
  22. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Mitochondrial dysfunction and abnormal fuel metabolism are linked to the development of obesity, diabetes and cardiovascular disease...
  23. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    ..These CYP26 inhibitors are also called retinoic acid metabolism blocking agents (RAMBAs)...
  24. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..CBS is a metabolic enzyme involved in the metabolism of sulfur containing amino acid such as methionine (Met)...
  25. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..B12 in the development of liver cancer;(4) to assess the role of genetic polymorphisms influencing methyl group metabolism in the development of liver cancer, and their modifying effect on the associations between methyl groups and ..
  26. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..Sphingolipids serve structural membrane functions, whereas their metabolism produces signaling molecules involved in regulating mammalian development, immune function, inflammation and ..
  27. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..In the INS resistant state, myocardial and skeletal muscle glucose uptake and metabolism is impaired, leading to diastolic dysfunction, attenuated myocardial and skeletal muscle blood flow, and ..
  28. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..disease risk factors including insulin resistance, high blood pressure and dysregulation of lipid and glucose metabolism. Stearoyl-CoA desaturase- 1 (SCD1) is increased in obesity and catalyzes the conversion of saturated fatty acids ..
  29. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..Alterations of energy metabolism resulting from dysregulation of CPT1 affects insulin sensitivity, appetite regulation, and a growing list of ..
  30. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..I will develop a working knowledge of immunological function and understand the impact of cytokines and TRP-KYN metabolism on neuroinflammatory processes in the CNS. This training will take place under the mentorship of Drs...
  31. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..Directed changes in bacterial metabolism are made by modifying specific biochemical reactions or by introducing new ones...
  32. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..The role of lipid aldehydes and their metabolism on the susceptibility of epithelial target cells to CIN will be evaluated. The ability of E...
  33. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ..will determine whether one of two resistance exercise protocols improves pain, physical function, and cartilage metabolism in older persons with knee OA. This is a repeated-measures, three group design...
  34. Med1 in Liver Metabolism, Regeneration and Cancer
    Janardan K Reddy; Fiscal Year: 2013
    ..a pivotal role in energy homeostasis by orchestrating biochemical pathways of carbohydrate, fat, and protein metabolism and exhibits inherent compensatory regeneration capacity to regain partially lost metabolic functions...
    Gary Cecchini; Fiscal Year: 2013
    ..Reducing equivalents generated by the TCA cycle and fatty acid metabolism are used by NADH-ubiquinone reductase (complex I), succinate-ubiquinone reductase (complex II), and ETF-quinone ..
  36. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Mitochondria are essential organelles for cellular metabolism and survival...
    Maureen J Charron; Fiscal Year: 2010
    ..studies are proposed to test the response of high fat IU offspring to diets that alter body weight and metabolism including a high fat diabetogenic diet or a weight loss ketogenic diet during their adult life...
  38. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009 whether MYCN overexpression in NB cells impacts endogenous ODC and other metabolic enzymes of polyamine metabolism, and whether this translates into changes in polyamine pools, cell cycle progression, and cell proliferation...
  39. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    DESCRIPTION: Androgen action is the net result of opposing pathways of steroid biosynthesis and metabolism. It is now widely recognized that testosterone (T) is an androgenic precursor of the more potent 5[unreadable]-dihydrotestosterone ..
  40. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..In the course of this work, other important and heretofore unknown connections between dietary iron and metabolism emerged...
  41. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..of these mice, to determine the full range of 13(V) roles in ultrastructure, cell biology, development, metabolism, homeostasis and disease - the latter including possible heritable diseases and/or predispositions to chronic ..
  42. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..One adverse action of alcohol involves promotion of tissue and organ damage by impairing retinoid metabolism and actions in liver (where 70% of the body's retinoid is stored) and in peripheral tissues...
  43. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..The current study goals are investigating the effect of the mutation on metabolism of glucose and insulin secretion and function in patients with this mutation.
  44. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..discovered important roles for myocardial insulin signaling in the regulation of myocardial mitochondrial energy metabolism, and a role for insulin signaling in regulating myocardial size and in limiting injury in the presence of ..
  45. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..However, the diagnostic importance of altered iron metabolism in ACD has led many investigators to consider that this feature denotes the dominant pathophysiologic mechanism ..
  46. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..between rest and motion, thus influencing multiple aspects of our life, including physical conditioning, metabolism, and even body weight...
  47. Mitochondrial Dysfunction and Adipose Insulin Resistance
    David A Bernlohr; Fiscal Year: 2013
    ..Specific Aim 4. Characterize cellular metabolism and the Trx2-ASK1-JNK pathway in animal and cell culture models...
  48. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ..The proposal involves the application of a novel assay for the iron metabolism hormone hepcidin in the approach to prevent, diagnose, and treat iron deficiency in infants...
  49. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..have high perinatal mortality from abnormal intestinal and pancreatic function, altered glucose and lipid metabolism, and lung infections...
  50. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..of hypertension is unknown, but some investigators have demonstrated that abnormal renal prostaglandin metabolism, which affects Na homeostasis, can lead to Na retention and hypertension...
  51. Neuroprotection and Myelin Repair Mechanisms in Multiple Sclerosis
    Inderjit Singh; Fiscal Year: 2013
    ..AMPK), a phylogenetically conserved, intracellular energy sensor switch which helps regulate glucose and lipid metabolism, in the context of the survival and differentiation of oligodendrocyte (OP) progenitor cells (OPCs) in an ..
  52. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..a mammalian ligand for 24p3 as a prerequisite to understanding the role of 24p3 and its ligand in cellular iron metabolism. Mass spectrometry (MS) of mammalian-derived 24p3 identified Dihydroxy Benzoic Acid (DHBA) as a co-purifying ..
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..Binding protein-beta (C/EBP-2), a transcription factor known to regulate cell differentiation, energy metabolism, immune response, tumor growth and apoptosis...
    Lisa M Salati; Fiscal Year: 2012
    ..Much less is known about how non-pathological fluctuations in dietary fat intake alter intracellular metabolism and how these signaling actions affect events in the nucleus...
  55. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012 to become an independent investigator in the areas of maternal nutrition and placental nutrient transport and metabolism. Her long-term career objective is to build a strong translational research program, utilizing appropriate ..
  56. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..necessary and sufficient for suppression of lethal immunopathology by producing a specific enzyme of L-arginine metabolism called arginase...
  57. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    ..menthol cigarettes, studies of biological markers of smoking demonstrate that menthol itself inhibits nicotine metabolism, and that menthol cigarette smoking leads to elevated serum levels of nicotine and cotinine, and greater exhaled ..
  58. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2013
    ..This syndrome of interrelated bone disease, extraskeletal calcification, and disordered mineral metabolism is called Chronic Kidney Disease Mineral Bone Disorder (CKD-MBD)...
  59. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..Acrolein is also generated endogenously due to cellular metabolism, and this may constitute a significant source of intracellular acrolein in situations of oxidative stress and ..
  60. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..In both men and women steroids control many vital processes, including carbohydrate, lipid, and protein metabolism, and sexual function...
  61. Notch and Regulators of Notch Signaling Impact Both Glucose and Lipid Metabolism
    UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2013
    ..development and thereafter remain quiescent unless inappropriately activated in cancer, in regulation of hepatic metabolism through its interaction with FoxO1, a transcription factor known to modulate insulin sensitivity...
  62. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..formation protein uniquely secreted by osteoblasts, may play a crucial role in endocrine regulation of energy metabolism by enhancing b-cell proliferation, insulin production, insulin sensitivity and adiponectin expression as a ..
  63. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..evolved in lower animalsto enable a wide range of physiological processes including smell, food consumption, metabolism, growth, reproduction and dormancy...
  64. Cellular Efflux and Metabolism of Protease Inhibitors
    Ashim Mitra; Fiscal Year: 2004
    ..of this study is to classify all anti-AIDS drugs, currently used clinically, under a new proposed Absorption-Metabolism Classification System (AMCS)...
  65. Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammals
    Rochelle W Tyl; Fiscal Year: 2009
    Keywords;Absorption;Distribution;Metabolism;Excretion;ADME;Metabolite identification;toxicokinetics;Mechanisms of toxicity;2,3-butanedione;diacetyl;N,N-dimethylacetoacetamide;obliterative bronchiolitis;CYP;eugenol;safrole;estragole;..
    Stephen M Beverley; Fiscal Year: 2010
    ..identified through the study of antifolate-resistant Leishmania parasites, which has lead us into studies of the metabolism of the unconjugated pteridine biopterin and the conjugated pteridine folate, and the development and application ..
    Dimitris Tatakis; Fiscal Year: 1991
    ..that leukotrienes (arachidonic acid metabolites derived from the lipoxygenase pathway) may also affect bone metabolism. However, there appears to be no information available about the possible role of lipoxins in bone physiology...
  68. Assessment of Nicotine Metabolism Among Underserved Pregnant Women from NE SCRIPT
    Donna Parker; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Assessment of Nicotine Metabolism Among Underserved Pregnant Women from NE SCRIPT Principal Investigator: Parker, Donna R...
  69. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The uptake and metabolism of ketone bodies in brain have been of interest to researchers and clinicians for decades but how they affect the coupling of blood flow and glucose metabolism, especially ..
  70. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
    ..This revision also serves to create new research objectives to explore the associations of nicotine metabolism and oxidative stress genetics outside of the scope of the parent grant, and will be completed in less than one ..
    Cynthia Morris; Fiscal Year: 1990
    The importance of maintaining dietary calcium intake and normal calcium metabolism for optimal regulation of arterial pressure in humans and experimental models has been demonstrated by us and other investigators...