neutrophil infiltration

Summary

Summary: The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.

Top Publications

  1. pmc Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration
    Yu Hua Liao
    Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    J Am Coll Cardiol 59:420-9. 2012
  2. ncbi Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
    Jonathan R Mathias
    University of Wisconsin Madison, 2715 Medical Sciences Center, 1300 University Ave, Madison, WI 53706, USA
    J Leukoc Biol 80:1281-8. 2006
  3. ncbi Altered chemokine expression in the spinal cord and brain contributes to differential interleukin-1beta-induced neutrophil recruitment
    Sandra J Campbell
    Molecular Neuropathology Laboratory and CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton, UK
    J Neurochem 83:432-41. 2002
  4. ncbi Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury
    Bridgette D Semple
    National Trauma Research Institute, The Alfred Hospital, Melbourne, Victoria, Australia
    Neurobiol Dis 40:394-403. 2010
  5. ncbi Pulmonary neutrophil infiltration in murine sepsis: role of inducible nitric oxide synthase
    Habib M Razavi
    Vascular Biology Group, Lawson Health Research Institute, Division of Respirology, Department of Medicine, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada
    Am J Respir Crit Care Med 170:227-33. 2004
  6. ncbi Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia
    Peter Rosenberger
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen 72076, Germany
    Nat Immunol 10:195-202. 2009
  7. ncbi Immunomodulatory effects of etanercept in an experimental model of spinal cord injury
    Tiziana Genovese
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina Italy
    J Pharmacol Exp Ther 316:1006-16. 2006
  8. pmc Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration
    Sumanta Dey
    Division of Infectious Diseases and Immunology, Council of Scientific and Industrial Research Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, West Bengal, India
    J Biol Chem 287:26630-46. 2012
  9. ncbi Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice
    Fredrik Clausen
    Department of Neuroscience, Section for Neurosurgery, Uppsala University, Uppsala, Sweden
    Eur J Neurosci 30:385-96. 2009
  10. ncbi Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration
    Nicole Bye
    National Trauma Research Institute and Department of Trauma Surgery, Alfred Hospital, Victoria, Australia
    Exp Neurol 204:220-33. 2007

Detail Information

Publications304 found, 100 shown here

  1. pmc Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration
    Yu Hua Liao
    Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    J Am Coll Cardiol 59:420-9. 2012
    ..This study tested whether interleukin (IL)-17A is involved in the pathogenesis of mouse myocardial ischemia/reperfusion (I/R) injury and investigated the mechanisms...
  2. ncbi Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
    Jonathan R Mathias
    University of Wisconsin Madison, 2715 Medical Sciences Center, 1300 University Ave, Madison, WI 53706, USA
    J Leukoc Biol 80:1281-8. 2006
    ..The zMPO:GFP zebrafish provides unique insight into the mechanisms of neutrophil-mediated inflammation and thereby offers opportunities to identify new regulators of the inflammatory response in vivo...
  3. ncbi Altered chemokine expression in the spinal cord and brain contributes to differential interleukin-1beta-induced neutrophil recruitment
    Sandra J Campbell
    Molecular Neuropathology Laboratory and CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton, UK
    J Neurochem 83:432-41. 2002
    ..No expression of CINC-2beta mRNA was detected. Thus differential chemokine induction may contribute to variations in neutrophil recruitment in during development and between the different CNS compartments...
  4. ncbi Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury
    Bridgette D Semple
    National Trauma Research Institute, The Alfred Hospital, Melbourne, Victoria, Australia
    Neurobiol Dis 40:394-403. 2010
    ..We demonstrate a significant attenuation of neutrophil infiltration in Cxcr2(-/-) mice at 12 hours and 7 days after CHI, despite increased levels of CXC neutrophil-..
  5. ncbi Pulmonary neutrophil infiltration in murine sepsis: role of inducible nitric oxide synthase
    Habib M Razavi
    Vascular Biology Group, Lawson Health Research Institute, Division of Respirology, Department of Medicine, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada
    Am J Respir Crit Care Med 170:227-33. 2004
    ..The effect of iNOS on pulmonary neutrophil infiltration in ALI is not known...
  6. ncbi Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia
    Peter Rosenberger
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen 72076, Germany
    Nat Immunol 10:195-202. 2009
    ..Our studies demonstrate that HIF-1alpha-dependent induction of netrin-1 attenuates hypoxia-elicited inflammation at mucosal surfaces...
  7. ncbi Immunomodulatory effects of etanercept in an experimental model of spinal cord injury
    Tiziana Genovese
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina Italy
    J Pharmacol Exp Ther 316:1006-16. 2006
    ..Spinal cord injury in mice resulted in severe trauma characterized by edema, neutrophil infiltration, and cytokine production that it is followed by recruitment of other inflammatory cells, such as ..
  8. pmc Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration
    Sumanta Dey
    Division of Infectious Diseases and Immunology, Council of Scientific and Industrial Research Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, West Bengal, India
    J Biol Chem 287:26630-46. 2012
    ..of serum TNFα in infected mice, and the treatment of anti-TNFα antibodies also significantly prevented neutrophil infiltration and liver injury...
  9. ncbi Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice
    Fredrik Clausen
    Department of Neuroscience, Section for Neurosurgery, Uppsala University, Uppsala, Sweden
    Eur J Neurosci 30:385-96. 2009
    ....
  10. ncbi Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration
    Nicole Bye
    National Trauma Research Institute and Department of Trauma Surgery, Alfred Hospital, Victoria, Australia
    Exp Neurol 204:220-33. 2007
    ..response, in that microglial activation and interleukin-1beta expression are reduced, while neutrophil infiltration and expression of multiple cytokines are not affected...
  11. ncbi Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection
    Yi Wei Li
    Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, People s Republic of China
    J Hepatol 54:497-505. 2011
    b>Neutrophil infiltration has been linked to clinical outcome of various cancer types. However, its role in hepatocellular carcinoma (HCC) is unclear...
  12. pmc Interleukin-4 (IL-4) and IL-13 suppress excessive neutrophil infiltration and hepatocyte damage during acute murine schistosomiasis japonica
    Takenori Seki
    Section of Environmental Parasitology, Tokyo Medical and Dental University Graduate School of Medical and Dental Science, Tokyo, Japan
    Infect Immun 80:159-68. 2012
    ..Infected DKO mice also showed increased neutrophil infiltration accompanying more severe pathology, as shown by the enhanced necrosis of hepatocytes...
  13. pmc Adenoma formation following limited ablation of p120-catenin in the mouse intestine
    Whitney G Smalley-Freed
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e19880. 2011
    ..Indeed, although technical issues precluded direct identification of mutations, β-catenin upregulation in human colon cancer almost invariably reflects mutations in APC and/or β-catenin...
  14. ncbi CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1
    Saskia Braber
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Eur J Pharmacol 668:443-9. 2011
    ....
  15. ncbi The chemokine decoy receptor D6 prevents excessive inflammation and adverse ventricular remodeling after myocardial infarction
    Clément Cochain
    Universite Paris Descartes, Inserm UMR S970, Paris Cardiovascular Research Center, Hôpital Européen Georges Pompidou Paris, France
    Arterioscler Thromb Vasc Biol 32:2206-13. 2012
    ..Here, we hypothesized that the chemokine decoy receptor D6, which specifically binds and scavenges inflammatory CC-chemokines, might limit inflammation and adverse cardiac remodeling after infarction...
  16. ncbi Mechanisms and roles of neutrophil infiltration in stress-induced gastric injury in rats
    M Hamaguchi
    Department of Gastroenterology, Osaka City University Medical School, Osaka, Japan
    Dig Dis Sci 46:2708-15. 2001
    Water-immersion and restraint stress is associated with an increase in neutrophil infiltration into the gastric mucosa, but the mechanism responsible for this infiltration is unclear...
  17. ncbi Polymorphonuclear neutrophils and cancer: intense and sustained neutrophilia as a treatment against solid tumors
    Juan Carlos Souto
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Med Res Rev 31:311-63. 2011
    ..This antitumoral role of neutrophils may provide new avenues for the clinical treatment of cancer...
  18. ncbi Inhibition of neutrophil infiltration into A549 lung tumors in vitro and in vivo using a CXCR2-specific antagonist is associated with reduced tumor growth
    Simon Tazzyman
    Academic Unit of Inflammation and Tumor Targeting, Faculty of Medicine, Health and Dentistry, University of Sheffield, Sheffield, United Kingdom
    Int J Cancer 129:847-58. 2011
    ..b>Neutrophil infiltration into A549 tumor spheroids increased their size compared to noninfiltrated spheroids and neutrophil-..
  19. pmc Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice
    Hoyong Lim
    Center for Immunology and Autoimmune Diseases, Institute of Molecular Medicine, The University of Texas Medical School at Houston, TX, USA
    PLoS ONE 7:e52666. 2012
    ..Our findings demonstrate that C3a signals negatively regulate antigen-specific Th17 responses during allergic lung inflammation and the size of Foxp3(+) regulatory T cell population in the periphery...
  20. pmc Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection
    Lauren C Frazer
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    Infect Immun 79:4029-41. 2011
    ..These data support the role of neutrophils in chlamydia-induced pathology and reveal that novel methods of depletion must be developed before their role can be specifically determined in vivo...
  21. pmc Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice
    Jakob Axelsson
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093, USA
    Blood 120:1742-51. 2012
    ..a type of sulfated glycosaminoglycan, facilitates neutrophil recruitment based on the reduction of neutrophil infiltration in mice in which the overall sulfation of the chains was reduced by selective inactivation of N-..
  22. pmc Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice
    Ellinor Kenne
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Neuroinflammation 9:17. 2012
    ..Neutrophils are known to cause increased vascular permeability leading to edema formation in peripheral tissue, but their role in the pathology following TBI remains unclear...
  23. pmc An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse
    Tatiana Aparecida Pimentel
    Post Graduation in Morphology, Federal University of Sao Paulo UNIFESP, Paulista School of Medicine EPM, Rua Botucatu, Sao Paulo, Brazil
    Lab Invest 91:33-42. 2011
    ..Arthritis develop after immunization, gradually increased up to day 42. Neutrophil infiltration peaked on day 32 and 21, in the digits and knees, respectively, showing an unequal pattern of recruitment ..
  24. ncbi Therapeutic effect of blocking CXCR2 on neutrophil recruitment and dextran sodium sulfate-induced colitis
    Shukkur Muhammed Farooq
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    J Pharmacol Exp Ther 329:123-9. 2009
    ..Antagonizing CXCR2 may form the basis for therapeutic drugs directed at controlling colitis...
  25. pmc Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice
    D Torres-Dueñas
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, Sao Paulo, Brazil
    Br J Pharmacol 152:341-52. 2007
    ..The present study addresses the possibility that peroxynitrite (ONOO(-)), a NO-derived powerful oxidizing and nitrating compound, could also be involved in neutrophil migration failure...
  26. pmc P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    J Neuroinflammation 7:65. 2010
    ..In the present study, we investigated the roles of P2X7 receptor in recruitment and infiltration of neutrophil during epileptogenesis in rat epilepsy models...
  27. pmc Protective role of IL-1β against post-arthroplasty Staphylococcus aureus infection
    Nicholas M Bernthal
    Orthopaedic Hospital Research Center, Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    J Orthop Res 29:1621-6. 2011
    ..Taken together, these findings suggest a mechanism by which IL-1β induces neutrophil recruitment to help control the bacterial burden and the ensuing biofilm formation in a post-surgical joint...
  28. ncbi Ghrelin improves burn-induced multiple organ injury by depressing neutrophil infiltration and the release of pro-inflammatory cytokines
    Ozer Sehirli
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Peptides 29:1231-40. 2008
    ..According to the findings of the present study, ghrelin possesses a neutrophil-dependent anti-inflammatory effect that prevents burn-induced damage in skin and remote organs and protects against oxidative organ damage...
  29. pmc Selective renal overexpression of human heat shock protein 27 reduces renal ischemia-reperfusion injury in mice
    Minjae Kim
    Departments of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032 3784, USA
    Am J Physiol Renal Physiol 299:F347-58. 2010
    ..apoptosis, and inflammation as demonstrated by decreased proinflammatory cytokine mRNA induction and neutrophil infiltration. In addition, there was better preservation of the proximal tubule epithelial filamentous (F)-actin ..
  30. ncbi Neutrophil infiltration of culprit lesions in acute coronary syndromes
    Takahiko Naruko
    Department of Cardiology, Osaka City General Hospital, Osaka
    Circulation 106:2894-900. 2002
    ..Neutrophils in unstable atherosclerotic lesions have not received much consideration, despite accumulating evidence suggesting a link between systemic inflammation and acute coronary syndromes...
  31. ncbi Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitis
    Udayan M Apte
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    Toxicol Appl Pharmacol 207:25-38. 2005
    ..second and rate-limiting step in the progression of ALD, is characterized by hepatic fat accumulation, neutrophil infiltration, and neutrophil-mediated parenchymal injury. However, the pathogenesis of ASH is poorly defined...
  32. ncbi Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment
    Matthew J Ruddy
    Department of Microbiology and Immunology, University at Buffalo, SUNY, 36 Foster Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Leukoc Biol 76:135-44. 2004
    ..This study is the first demonstration of LIX expression in bone cells and has implications for inflammatory bone diseases such as arthritis and periodontal disease...
  33. ncbi Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney
    Sarah Faubel
    Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Box C281, 4200 E 9th Ave, Denver, CO 80262, USA
    J Pharmacol Exp Ther 322:8-15. 2007
    ..dramatically after cisplatin injection; however, prevention of peripheral neutrophilia and renal neutrophil infiltration with the neutrophil-depleting antibody RB6-8C5 did not protect against cisplatin-induced ARF...
  34. ncbi Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC)
    T C Dawson
    Department of Pathology, University of North Carolina, Chapel Hill, NC, USA
    Blood 96:1681-4. 2000
    ..These results suggest that DARC modulates the intensity of inflammatory reactions as a sink for chemokines. (Blood. 2000;96:1681-1684)..
  35. pmc Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 105:2640-5. 2008
    ..In summary, our studies verify a role for Bv8 in the mobilization and recruitment of myeloid cells and in the induction of tumor angiogenesis in the early stages of neoplastic progression...
  36. ncbi Pathobiology of neutrophil transepithelial migration: implications in mediating epithelial injury
    Alex C Chin
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Annu Rev Pathol 2:111-43. 2007
    ..A better understanding of this process will likely provide new insights into developing organ-specific treatment strategies to reduce the deleterious consequences of epithelial inflammation...
  37. ncbi Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice
    Fumitake Saito
    Division of Pulmonary Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Respir Cell Mol Biol 38:566-71. 2008
    ..These results indicate that IL-6 may play an important role in the pathogenesis of BLM-induced lung injury and subsequent fibrotic changes...
  38. ncbi Platelet interleukin-1alpha drives cerebrovascular inflammation
    Peter Thornton
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Blood 115:3632-9. 2010
    ....
  39. pmc Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging
    Min Ho Kim
    Department of Biomedical Engineering, University of California at Davis, Davis, California 95616, USA
    J Invest Dermatol 128:1812-20. 2008
    ..a non-invasive fluorescence-based imaging approach combined with genetic labeling of neutrophils provides a dynamic inner view of inflammation and the kinetics of neutrophil infiltration into the wounded skin over extended durations.
  40. ncbi Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
    Dominick E Shaw
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK
    Chest 132:1871-5. 2007
    ..Chronic inflammation is assumed to be important, although there is limited and contradictory information about the relationship between airway inflammation and postbronchodilator FEV1...
  41. ncbi Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network
    Andres Vazquez-Torres
    Department of Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:6202-8. 2004
    ..Alternative pattern-recognition receptors cannot completely compensate for the loss of TLR4, and compensation occurs at the expense of an increased microbial burden...
  42. pmc Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis
    Uwe Koedel
    Department of Neurology, Clinic of the University of Munich, Munich, Germany
    PLoS Pathog 5:e1000461. 2009
    ..These results indicate that apoptosis is essential to turn off activated neutrophils and show that inflammatory activity and disease severity in a pyogenic infection can be modulated by targeting the apoptotic pathway in neutrophils...
  43. pmc Neutrophils cascading their way to inflammation
    Christian D Sadik
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Immunol 32:452-60. 2011
    ..Recent data, however, suggest that neutrophil chemoattractants have unique functions in the recruitment of neutrophils into inflammatory sites in vivo, dictated by their distinct patterns of temporal and spatial expression...
  44. ncbi CXC chemokine receptor-2 ligands are required for neutrophil-mediated host defense in experimental brain abscesses
    T Kielian
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Immunol 166:4634-43. 2001
    ..These studies demonstrate the importance of the CXCR2 ligands MIP-2 and KC and neutrophils in the acute host response to S. aureus in the brain...
  45. ncbi CCL3/MIP-1alpha is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liver
    Maureen N Ajuebor
    Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Eur J Immunol 34:2907-18. 2004
    ..These findings demonstrate that blockade of the CCL3/MIP-1alpha-CCR1 pathway may represent a novel therapeutic target for treating T cell-mediated liver diseases...
  46. pmc Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro
    Michelle Lin
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106 7286, USA
    Am J Pathol 173:144-53. 2008
    ..to wild-type mice, we found that i) lipopolysaccharide (LPS)-injected CXCR2(-/-) corneas had impaired neutrophil infiltration and did not express either MMP-8 or MMP-9; ii) neutrophil migration through the central cornea was ..
  47. pmc Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production
    Henrique P Lemos
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo 14 049 900, Brazil
    Proc Natl Acad Sci U S A 106:5954-9. 2009
    ..We thus provide a mechanism for the pathogenic role of the IL-23/IL-17 axis in RA and also suggest an additional mechanism of action for nonsteroidal anti-inflammatory drugs...
  48. pmc MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury
    Leo E Otterbein
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Pathol 163:2555-63. 2003
    ....
  49. pmc Neutrophils: key mediators of tumour angiogenesis
    Simon Tazzyman
    Tumour Targeting Group, Academic Unit of Pathology, Medical School, University of Sheffield, Sheffield, UK
    Int J Exp Pathol 90:222-31. 2009
    ..We also discuss possible future chemotherapeutic strategies that are aimed at limiting tumour angiogenesis by inhibiting neutrophil recruitment...
  50. ncbi Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products
    Mirella Profita
    Institute of Biomedicine and Molecular Immunology, Italian National Research Council, via U La Malfa 153, 90146 Palermo, Italy
    Am J Physiol Lung Cell Mol Physiol 298:L261-9. 2010
    ..in induced sputum supernatants from different groups of subjects and correlated the obtained values to neutrophil infiltration as well as to the expression of cyclooxygenase-2 (COX-2)...
  51. pmc Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
    Jiyun V Kim
    Program in Molecular Pathogenesis, Helen L and Martin S Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nature 457:191-5. 2009
    ..We conclude that a CD8(+) T-cell-dependent disorder can proceed in the absence of direct T-cell effector mechanisms and rely instead on CTL-recruited myelomonocytic cells...
  52. pmc Human heat shock protein 27-overexpressing mice are protected against acute kidney injury after hepatic ischemia and reperfusion
    Sang Won Park
    Dept of Anesthesiology, Anesthesiology Research Laboratories, Columbia Univ, P and S Box 46 PH 5 630 W 168th St, New York, NY 10032 3784, USA
    Am J Physiol Renal Physiol 297:F885-94. 2009
    ..less induction of several proinflammatory mRNAs (TNF-alpha, MIP-2, and keratinocyte-derived cytokine), neutrophil infiltration, and reduction in apoptosis (terminal deoxynucleotidyl transferase biotin-dUTP nick end-labeling assay ..
  53. ncbi C5a-mediated leukotriene B4-amplified neutrophil chemotaxis is essential in tumor immunotherapy facilitated by anti-tumor monoclonal antibody and beta-glucan
    Daniel J Allendorf
    Tumor Immunobiology Program of the James Graham Brown Cancer Center, University of Louisville School of Medicine, KY 40202, USA
    J Immunol 174:7050-6. 2005
    ....
  54. ncbi In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1β-induced peritonitis
    Jian Song
    Institute for Physiological Chemistry and Pathobiochemistry, University of Muenster, 48149 Muenster, Germany
    J Immunol 190:401-10. 2013
    ..To our knowledge, this is the first in vivo demonstration of MMP-2 and MMP-9 processing of a chemokine that has been directly correlated with an enhanced chemoattracting function...
  55. ncbi Prognostic value of intratumoral neutrophils in advanced gastric carcinoma in a high-risk area in northern Italy
    Rosario Alberto Caruso
    Dipartimento di Patologia Umana, Policlinico Universitario G Martino, Messina, Italy
    Mod Pathol 15:831-7. 2002
    ....
  56. pmc Posttraumatic invasion of monocytes across the blood-cerebrospinal fluid barrier
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 32:93-104. 2012
    ..These data further support the pathophysiological role of BCSFB in promoting the recruitment of inflammatory cells to the injured brain...
  57. pmc Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats
    Caroline Belanger
    Faculty of Pharmacy, Universite de Montreal, Quebec, Canada
    Immunology 124:295-303. 2008
    ..Our results strongly support a role of both endogenous LTB(4) and PAF in regulating PMN trafficking to inflammatory sites in various experimental conditions...
  58. ncbi Recombinant human thioredoxin suppresses lipopolysaccharide-induced bronchoalveolar neutrophil infiltration in rat
    Shugo Ueda
    Thioredoxin Project, Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto, 606 8507, Japan
    Life Sci 79:1170-7. 2006
    ..Histological examination also showed that rhTRX decreased neutrophil infiltration in the lung tissues...
  59. ncbi Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues
    T Kobayashi
    Department of Internal Medicine, Second Teaching Hospital, School of Medicine, Fujita Health University, Nagoya, Aichi, 454-8509, Japan
    Pharmacol Res 43:23-30. 2001
    ..Recently, it has been implicated that neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues have an inhibitory effect on the healing of acetic ..
  60. ncbi Azithromycin inhibits macrophage interleukin-1β production through inhibition of activator protein-1 in lipopolysaccharide-induced murine pulmonary neutrophilia
    Martina Bosnar
    GlaxoSmithKline Research Centre Zagreb Limited, Prilaz baruna Filipovica 29, HR 10000 Zagreb, Croatia
    Int Immunopharmacol 11:424-34. 2011
    ..In addition, we have shown for the first time, in an in vivo model, that azithromycin inhibits AP-1 activation in alveolar macrophages, an action confirmed on J774.2 cells in vitro...
  61. ncbi The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?
    Dwaine F Emerich
    Life Sciences Research and Development, Alkermes, Cambridge, Massachusetts 02139, USA
    Exp Neurol 173:168-81. 2002
    ..For this reason we also offer suggestions for additional experiments and the inclusion of control groups that, in the future, might provide more effective or conclusive tests of the hypothesis...
  62. ncbi Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung
    Songen Zhang
    Department of Clinical Sciences, Section for Surgery, Malmo University Hospital, Lund University, Sweden
    Am J Physiol Lung Cell Mol Physiol 300:L930-9. 2011
    ..Bronchoalveolar fluid and lung tissue were harvested for determination of neutrophil infiltration, formation of edema, and CXC chemokines...
  63. pmc The role of neutrophils during mild and severe influenza virus infections of mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 6:e17618. 2011
    ....
  64. ncbi Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats
    Feng Bao
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    J Neurochem 88:1335-44. 2004
    ..on ED-1 expression (estimating macrophage infiltration), myeloperoxidase activity (MPO, approximating neutrophil infiltration), lipid peroxidation, inducible nitric oxide synthase (iNOS) and nitrotyrosine (indicating protein ..
  65. ncbi CXCR2 is required for neutrophil recruitment to the lung during influenza virus infection, but is not essential for viral clearance
    Mark D Wareing
    Viral Immunology, Torrey Pines Institute for Molecular Studies, San Diego, California 92121, USA
    Viral Immunol 20:369-78. 2007
    ..Thus, it appears that CXCR2 is the major receptor mediating neutrophil trafficking to the lung during influenza virus infection, but that neutrophils do not play an essential role in viral clearance...
  66. ncbi Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models
    Wei Zhou
    Department of Neurology, University Heidelberg, Heidelberg
    Brain Pathol 23:34-44. 2013
    ..b>Neutrophil infiltration was noted at 24 h after transient MCAO, but did not further increase until 5 days in the permanent MCAO ..
  67. pmc Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established disease
    Koichi Waseda
    Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Am J Respir Cell Mol Biol 45:851-7. 2011
    ..These data identify the importance of the LTB4-BLT1 pathway in the development of late-phase, allergen-induced airway responsiveness after secondary airway challenge in mice with established airway disease...
  68. pmc Efficacy and safety of inhaled carbon monoxide during pulmonary inflammation in mice
    Michael R Wilson
    Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, UK
    PLoS ONE 5:e11565. 2010
    ..Here we investigate the efficacy, safety and mechanism of action of low dose inhaled carbon monoxide (CO) using a mouse model of lipopolysaccharide (LPS)-induced pulmonary inflammation...
  69. pmc Mammalian target of rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection
    Megan E B Foldenauer
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 190:5649-58. 2013
    ..aeruginosa-induced bacterial keratitis and is critical to balancing pro- and anti-inflammatory events, resulting in better disease outcome...
  70. pmc Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon Do, South Korea
    J Neuroinflammation 9:6. 2012
    ....
  71. pmc Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
    Infect Immun 73:1754-63. 2005
    ....
  72. ncbi Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis
    Lior Raichel
    Infectious Diseases Laboratory, Department of Clinical Biochemistry, Faculty of Health Sciences, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Immunol 38:2905-15. 2008
    ..Our results demonstrate the critical role of cPLA2 for the duration of inflammation and suggest that inhibition of cPLA2 expression by antisense oligonucleotides may serve as an efficient treatment of inflammatory diseases...
  73. ncbi Antioxidant treatment reverses organ failure in rat model of sepsis: role of antioxidant enzymes imbalance, neutrophil infiltration, and oxidative stress
    Michael Andrades
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Surg Res 167:e307-13. 2011
    ....
  74. ncbi Streptococcal M1 protein-provoked CXC chemokine formation, neutrophil recruitment and lung damage are regulated by Rho-kinase signaling
    Songen Zhang
    Department of Clinical Sciences, Section for Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    J Innate Immun 4:399-408. 2012
    ..We conclude that Rho-kinase-dependent neutrophil infiltration controls pulmonary tissue damage in response to streptococcal M1 protein and that Rho-kinase signaling ..
  75. pmc Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia
    Marie Laure Michel
    Unité Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Faculté de Médecine René Descartes, Paris V, Hopital Necker, Paris, Cedex 15, France
    J Exp Med 204:995-1001. 2007
    ..Collectively, our findings reveal that NK1.1(neg) iNKT lymphocytes represent a new population of IL-17-producing cells that can contribute to neutrophil recruitment through preferential IL-17 secretion...
  76. pmc CXCL1/KC and CXCL5/LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis
    Michelle Lin
    Department of Ophthalmology and Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106 7286, USA
    J Leukoc Biol 81:786-92. 2007
    ..was injected into the corneal stroma of enhanced GFP chimeric mice prior to LPS, and total cell and neutrophil infiltration was examined...
  77. ncbi Comprehensive gene expression profiling in the prefrontal cortex links immune activation and neutrophil infiltration to antinociception
    Kay Wee Poh
    Department of Oral and Maxillofacial Surgery, National University of Singapore, Singapore 119260, Singapore
    J Neurosci 32:35-45. 2012
    ....
  78. pmc Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1
    Eric C Carlson
    Department of Ophthalmology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 282:35502-9. 2007
    ..LPS)-induced keratitis in which wild-type mice develop increased corneal thickness and haze due to neutrophil infiltration to the corneal stroma...
  79. pmc Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA Medical Center, USA
    J Neuroinflammation 7:38. 2010
    ..Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor (nAChR) alpha7...
  80. ncbi p38 Mitogen-activated protein kinase signaling regulates streptococcal M1 protein-induced neutrophil activation and lung injury
    Songen Zhang
    Section for Surgery, Malmo University Hospital, Malmo, Sweden
    J Leukoc Biol 91:137-45. 2012
    ..Edema, neutrophil infiltration, and CXC chemokines were determined in the lung, 4 h after M1 protein administration...
  81. pmc Increased expression of the chemokines CXCL1 and MIP-1α by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats
    Erik A Johnson
    Research Division, Pharmacology Branch, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010, USA
    J Neuroinflammation 8:41. 2011
    ..the regional and temporal progression of early chemotactic signals, describe the cellular expression of these factors and the relationship between expression and neutrophil infiltration in damaged brain using a rat GD seizure model.
  82. pmc Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis
    Kevin R Kasten
    Division of Research, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0558, USA
    Infect Immun 78:4714-22. 2010
    ..All together, these observations may underlay novel potential therapeutic targets to improve the host immune response to sepsis...
  83. pmc Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury
    Kaliyamurthi Venkatachalam
    Department of Veterans Affairs South Texas Veterans Health Care System and the Departments of Medicine and Surgery, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 284:7853-65. 2009
    ..and ischemia alone, I/R significantly increased (i) oxidative stress (increased MDA/4-HNE levels), (ii) neutrophil infiltration (increased MPO activity), (iii) NF-kappaB DNA binding activity (p50, p65), and (iv) increased expression ..
  84. pmc Chemokine CXCL16 regulates neutrophil and macrophage infiltration into injured muscle, promoting muscle regeneration
    Liping Zhang
    Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Pathol 175:2518-27. 2009
    ..Thus, CXCL16 expression is a critical mediator of muscle regeneration, and it suppresses the development of fibrosis...
  85. pmc Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice
    Manohar B Mutnal
    Neuroimmunology Laboratory, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Neuroimmunol 227:101-10. 2010
    ..Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared to wild-type animals...
  86. ncbi Transient neutrophil infiltration after allergen challenge is dependent on specific antibodies and Fc gamma III receptors
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 170:4301-9. 2003
    ..Further, mice lacking the FcgammaRIII did not develop this early neutrophil influx. Neutrophil infiltration could be induced in naive mice following intranasal instillation of allergen combined with allergen-..
  87. ncbi Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth
    Steve Lacroix
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Comp Neurol 454:213-28. 2002
    ..01) at the lesion site. Thus, potential neurotrophic properties of this cytokine family of growth factors must be balanced against their inflammatory properties when considering therapeutic application to CNS injury...
  88. pmc Strain differences in alveolar neutrophil infiltration and macrophage phenotypes in an acute lung inflammation model
    Yinzhong Zhang
    Center for Heart and Lung Research, Feinstein Institute for Medical Research, Manhasset, New York, USA
    Mol Med 17:780-9. 2011
    ..We conclude that the factors contributing to inflammation can be site and challenge dependent. A better understanding of site-specific inflammation may lead to more effective treatment of acute lung inflammation and injury...
  89. ncbi IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia
    Casey M Calkins
    Department of Surgery, University of Colorado Health Sciences Center and Veterans Affairs Hospital, 4200 East 9th Avenue, Box C 313, Denver, CO 80262, USA
    J Endotoxin Res 8:59-67. 2002
    ..These data suggest that IL-1 regulates tissue chemokine expression and neutrophil accumulation after LPS...
  90. pmc Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plague
    Nicholas A Eisele
    Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri 65211, USA
    Am J Pathol 178:1190-200. 2011
    ..Together, the data suggest CXCR2 uniquely induces host defense mechanisms that are effective against virulent Y. pestis, raising new insight into the activation of neutrophils during infection...
  91. pmc Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs
    Ravisankar A Ramadas
    Department of Pediatrics, University of Florida, Gainesville, USA
    Am J Respir Cell Mol Biol 44:134-45. 2011
    ..These data suggest that IL-1F9 is upregulated during inflammation, and acts as a proinflammatory cytokine in the lungs...
  92. pmc In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies
    Nathan C Peters
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 321:970-4. 2008
    ..Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease...
  93. ncbi Higher neutrophil infiltration mediated by osteopontin is a likely contributing factor to the increased susceptibility of females to alcoholic liver disease
    A Banerjee
    Department of Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, 77843 4467, USA
    J Pathol 208:473-85. 2006
    ..Although steatosis, necrosis, and neutrophil infiltration were evident in both male and female rats, hepatic neutrophilic necrotic foci were noted as early as 2 h ..
  94. ncbi Inflammation and angiotensin II
    Yusuke Suzuki
    Renal and Vascular Research Laboratory, Fundacion Jimenez Diaz, Autonoma University, Avda Reyes Catolicos 2, 28040 Madrid, Spain
    Int J Biochem Cell Biol 35:881-900. 2003
    ..Further understanding of the role of the RAS in this process may provide important opportunities for clinical research and treatment of inflammatory diseases...
  95. pmc Olprinone attenuates the acute inflammatory response and apoptosis after spinal cord trauma in mice
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    PLoS ONE 5:e12170. 2010
    ..The aim of the present study was to evaluate the pharmacological action of olprinone on the secondary damage in experimental spinal cord injury (SCI) in mice...
  96. ncbi T lymphocyte trafficking: a novel target for neuroprotection in traumatic brain injury
    Fredrik Clausen
    Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    J Neurotrauma 24:1295-307. 2007
    ..T lymphocyte and neutrophil infiltration peaked at 24 h and macrophages/microglia at 7 days post-injury...
  97. ncbi Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation
    Xiao Ming Gao
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Mol Cell Cardiol 50:991-9. 2011
    ..We have identified a critical role of MIF in mediating severe I/R injury. Thus, MIF inhibitory therapy may be a novel strategy to protect the heart against severe I/R injury...
  98. ncbi Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus
    Jessica G Moreland
    Division of Pediatric Critical Care, Department of Pediatrics, University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    J Immunol 172:426-32. 2004
    ..In addition, intact bacteria elicit PMN-endothelial cell interactions distinct from those seen when purified bacterial products are used as agonists...
  99. ncbi Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis
    Susana E Moreno
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Immunol 177:1264-71. 2006
    ..Altogether, the results firmly establish a role for PAFR in mediating the early impairment of neutrophil migration toward the infectious focus. Blockade of PAFR may prevent the establishment of severe sepsis...
  100. pmc IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610, USA
    J Immunol 186:1747-54. 2011
    ..Taken together, our findings uncover an IL-1α-dependent mechanism of neutrophil recruitment in hydrocarbon-induced peritonitis and illustrate the interactions of innate immune pathways in chronic inflammation...
  101. ncbi Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury
    Irene Paterniti
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    J Pharmacol Exp Ther 333:465-77. 2010
    ..SCI in mice resulted in severe trauma characterized by edema, neutrophil infiltration, production of inflammatory mediators, tissue damage, and apoptosis. GW0742 treatment (0.3 mg kg(-1) i.p...

Research Grants66

  1. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..a widespread expresion of pro-inflammatory genes that contribute to vascular permeability, lung edema, neutrophil infiltration, pulmonary shunt, and respiratory failure...
  2. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..of morphologic and biochemical endpoints, including lipid peroxidation (F21-isoprostane, GSH:GSSG ratio), neutrophil infiltration, 3- nitrotyrosine (3-NT), nitrite/nitrate, and poly(ADP-ribose) formation, BUN, creatinine, NGAL, AST, ..
  3. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..a widespread expression of pro-inflammatory genes that contribute to vascular permeability, lung edema, neutrophil infiltration, pulmonary shunt, and respiratory failure...
  4. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..redox stress induced by acute Cl2 gas inhalation, post-insult administration of R-901 reduced pulmonary neutrophil infiltration by 50%...
  5. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..other airway diseases including the Chronic Obstructive Pulmonary Disease (COPD)) are associated with neutrophil infiltration of the airway wall...
  6. A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia
    Prakash Jagtap; Fiscal Year: 2013
    ..In a murine ovalbumin model of pulmonary inflammation model, R-901 reduced histologic injury, diminished neutrophil infiltration, attenuated tissue oxidation, blocked pro-inflammatory cytokine expression and nuclear translocation of ..
  7. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ..b>Neutrophil infiltration is a hallmark of alcoholic hepatitis, and infiltrating neutrophils are thought to play an etiologic role ..
  8. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..These findings are expected to parallel the effects of mR-421 on synovial lipid peroxidation, neutrophil infiltration, pro-inflammatory gene expression peroxynitrite production, poly(ADP-ribose)polymerase formation, and ..
  9. Novel therapeutics for vesicants and toxic inhaled chemicals (U54)
    Carl W White; Fiscal Year: 2013
    ..and methacholine reactivity due to chlorine;and d) skin injuries by CEES such as inflammation and neutrophil infiltration. A natural dietary supplement silibinin also rescued skin injuries by CEES...
  10. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013
    ..of acute LIRI that R-100 resuscitation profoundly reduces limb histologic damage, lipid peroxidation, neutrophil infiltration, and % of injured muscle...
  11. TNF and Mitochondrial Dysfunction in ALD
    Craig J McClain; Fiscal Year: 2010
    ..With decreased proteasome function and hepatocyte injury/death, there is increased IL-8 productionwith neutrophil infiltration andincreasedIL-18 production that sustainsthis inflammatorycytokine response...
  12. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
    ..neutrophil recruitment are due to inhibition of ECM degradation;and determine whether apo(a) suppresses neutrophil infiltration into the vessel wall after injury in apo(a) transgenic mice in Plg-replete or Plg-deficient backgrounds ..
  13. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..In neither mouse, however, are differences from WT found in measures of the severity (edema, T cell and neutrophil infiltration, and expression of IL1 , IFN , and TNF ) of delayed type hypersensitivity evoked in the ears with ..
  14. Novel Glycosaminoglycan Derivatives for Treatment of Bladder Inflammation
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..Tissues will be analyzed histologically for myeloperoxidase activity to quantify neutrophil infiltration. Preliminary data suggest that GM-1111 coats the uroepithelium and reduces bladder inflammation...
  15. MECHANISMS OF SALMONELLA INVASION AND TRANSMIGRATION
    James E Casanova; Fiscal Year: 2013
    ..Conversely, neutrophil infiltration into the same tissues is enhanced, suggesting a differential regulation of macrophage and neutrophil ..
  16. Acute Humoral Rejection of Renal Allografts
    Robert L Fairchild; Fiscal Year: 2013
    ..Project 1 will study the impact of graft-reactive antibody induced neutrophil infiltration and activation on acute graft injury and the development of interstitial fibrosis in renal allografts ..
  17. Molecular Control of Gut Permeability in Trauma
    Mack H Wu; Fiscal Year: 2013
    ..is that inflammation in the intestinal microcirculation induces endothelial paracellular leakage and neutrophil infiltration into lamina propria leading to mucosal barrier failure...
  18. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2013
    ..The over-arching hypothesis to be tested in this research is that vascular inflammation due to neutrophil infiltration is critical to the pathophysiology of preeclampsia...
  19. A Novel Therapeutic Approach for Liver Injury
    Xiaoling Qiang; Fiscal Year: 2010
    ..AM) immediately at the onset of reperfusion, downregulated pro-inflammatory cytokines, decreased hepatic neutrophil infiltration, inhibited liver cell apoptosis and necrosis, and reduced liver injury and mortality in a rat model of ..
  20. Pyruvate: Powerful Brain Protection after Cardiac Arrest
    Robert T Mallet; Fiscal Year: 2013
    ..Erythropoietin mRNA and protein content, signaling kinase activation, neutrophil infiltration, and activities of proapoptotic caspases, pro-inflammatory matrix metalloproteinases, and the ..
  21. Acute Renal Failure Mediated Lung Injury
    Sarah Faubel; Fiscal Year: 2013
    ..The effect of IL-6 on lung injury and KC (a mediator of neutrophil infiltration) will be tested IL-6 deficient and IL-6 inhibitor-treated mice with ischemic AKI or bilateral nephrectomy...
  22. Vascular adhesion protein-1 (VAP-1) as a therapeutic target in stroke
    DALE ALAN PELLIGRINO; Fiscal Year: 2013
    ..of VAP-1/SSAO, during the reperfusion period following transient forebrain ischemia (TFI), prevented neutrophil infiltration into the brain, and was associated with a 6h post-ischemic therapeutic window in animals where heightened ..
  23. Liver innate immunity in drug-induced liver disease.
    Zhang Xu Liu; Fiscal Year: 2012
    ..the protection was correlated with inhibition of inflammatory cytokine/chemokine production and hepatic neutrophil infiltration, 3) as the downstream event of NK/NKT activation, recruited hepatic neutrophils also contribute to liver ..
  24. Corneal Expression and Function of Slurp1
    SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2013
    ..lipopolysaccharide (LPS) injection or Herpes Simplex Virus type-1 (HSV-1) infection concurrent with neutrophil infiltration, (iii) decreased in the inflamed Klf4-conditional null (Klf4CN) corneas, and (iv) suppressed by pro-..
  25. Intestinal Barrier Function: Protective Effects of Curcumin
    Pawel R Kiela; Fiscal Year: 2013
    ..Chronic and severe neutrophil infiltration, transepithelial migration and enzymatic and oxidative damages of the epithelium and the extracellular ..
  26. Epithelial-derived mediators of neutrophil infiltration in the intestine
    ROSE LINDA SZABADY; Fiscal Year: 2013
    ..Typhimurium cause inflammatory diarrhea that mimics several clinical hallmarks of IBD including massive neutrophil infiltration into the intestine...
  27. A novel therapeutic strategy for Acute Lung Injury: Inhibition of PKC-delta
    JOHN T SWINDLE; Fiscal Year: 2012
    ..ALI/ARDS is characterized by an intense systemic inflammatory response leading to neutrophil infiltration of the lungs and lung tissue damage...
  28. Targeting a leukocyte disintegrin metalloprotease during bacterial pneumonia
    Bruce K Walcheck; Fiscal Year: 2013
    ..recruitment of neutrophils, and we have determined that the protease ADAM17 is an important gatekeeper of neutrophil infiltration from the blood into the lungs during P. aeruginosa infection...
  29. KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASE
    Robert Colman; Fiscal Year: 2001
    ..A specific kallikrein inhibitor decreases CS activation, acute inflammatory changes (edema, neutrophil infiltration), chronic intestinal inflammation and the systemic complications (arthritis, splenomegaly, hepatomegaly, ..
  30. Mechanisms of neuronal injury during virus infection of the CNS
    CHARLES LEE HOWE; Fiscal Year: 2012
    ..We have further observed that neutrophils infiltrate the hippocampus within hours of infection. Reduced neutrophil infiltration is neuroprotective, while adoptive transfer of activated neutrophils into mice with a defective ..
  31. Innate Mechanisms Regulating CD8+ T Cell Immunity
    ROBERT LESLIE FAIRCHILD; Fiscal Year: 2010
    ..These chemokines direct neutrophil infiltration into the hapten challenge site and this infiltration is required for the subsequent recruitment of the ..
  32. Biology, Immunology &therapy of Acanthamoeba Keratitis
    Hassan Alizadeh; Fiscal Year: 2013
    ..antibodies that will neutralize the pathogenic molecules and thus, mitigate tissue damage and reduce neutrophil infiltration. Thus, the protective and destructive roles of PMNs influence the outcome of Acanthamoeba infection and ..
  33. Neutrophil-epithelial interaction mediated by adenosine
    Didier Merlin; Fiscal Year: 2013
    ..neutrophil recruitment in response to inflammatory stimuli;v) A2BAR antagonism or gene deletion inhibits neutrophil infiltration;vi) genetic ablation of A2BAR in mice protects against bacterial and chemically-induced diarrhea and ..
  34. Targeted Delivery of iPS-Endothelial Cells for the Repair of Cardiovascular Injur
    Yiu Fai Chen; Fiscal Year: 2013
    ..to endoluminal surface and adventitia of injured arteries) and in doing so will compete with and inhibit neutrophil infiltration and attenuate subsequent inflammatory responses and structural and functional damage to tissues...
  35. Post-Transplant Inflammatory Response
    Robert L Fairchild; Fiscal Year: 2012
    ..g. 9-24 hours post-transplant) infiltration of neutrophils into cardiac iso- and allo-grafts. However, neutrophil infiltration into allografts is increased 3-4 fold compared to isografts and is associated with detectable areas of ..
  36. Novel Protein Kinase C Targeted Therapy for Acute Lung Injury
    Laurie E Kilpatrick; Fiscal Year: 2013
    ..ALI/ARDS is characterized by an intense inflammatory response leading to neutrophil infiltration of the lungs and lung tissue damage...
  37. The role of neutrophils in SAH
    JOSE JAVIER PROVENCIO; Fiscal Year: 2011
    ..b>Neutrophil infiltration is the predominant early inflammatory response in subarachnoid hemorrhage;however, the role of ..
  38. Role of Adaptive Immunity in the Development of Colitis in TLR5 Deficient Mice
    Matam Vijay Kumar; Fiscal Year: 2013
    ..Active flares of IBD are associated with, and thought to be mediated by, innate immunity, specifically neutrophil infiltration to the intestinalmucosa...
  39. Multifunctional therapeutics for treatment of acute chlorine inhalational injury
    GARRY JOHN SOUTHAN; Fiscal Year: 2013
    ..of R-503, R-801, or R-901 initiated 15 min AFTER the end of chlorine inhalation reduced the elevation in neutrophil infiltration by 50-82% (p<0.0001) and histologic injury by 43-72% (p<0.001)...
  40. Early inflammatory responses to high saturated fat diet
    Christina Camell; Fiscal Year: 2012
    ..Three days of HSF diet results in neutrophil infiltration of murine adipose tissues, and a single meal induces transient endotoxemia and leukocyte activation in ..
  41. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..A specific kallikrein inhibitor decreases both the KKS activation and acute inflammatory changes (edema, neutrophil infiltration) and prevented arthritis and the systemic complications (splenomegaly, hepatomegaly, leukocytosis and the ..
  42. T cell-mediated lung ischemia-reperfusion injury
    Victor E Laubach; Fiscal Year: 2013
    ..Thus Aim 1 will determine if iNKT cells initiate lung IR injury and neutrophil infiltration via IL-17 production...
  43. Role of Rpl22 in ER Stress and Colitis
    David L Wiest; Fiscal Year: 2013
    ..Preliminary data indicate that neutrophil infiltration is enhanced in Rpl22 mutant mice;moreover, these neutrophils exhibited features characteristic of ..
  44. Proteoglycans in Lung Innate Immunity and Host Defense
    Pyong Woo Park; Fiscal Year: 2012
    ..shedding promotes pneumococcal pneumonia are not known, but shedding enhances CXC chemokine-induced neutrophil infiltration in mice, and shed ectodomains inhibit several antibacterial factors expressed in airway surface fluids in ..
  45. A Novel Class of Topical Pleitropic Anti-Acne Therapeutics
    Joel S Gordon; Fiscal Year: 2010
    ..inflammatory model, our results demonstrate IPC analogs have strong anti-inflammatory activity inhibiting neutrophil infiltration, edema and erythema of the skin...
  46. Aging effects on acute lung inflammation after burn injury
    Vanessa Nomellini; Fiscal Year: 2010
    ..To study the effects of these chemokines on neutrophil infiltration into the lungs, we will use antibodies to block those factors and examine the pulmonary consequences in ..
  47. Ex vivo perfusion in a lung box for rehabilitation of donor lungs
    Victor E Laubach; Fiscal Year: 2013
    ..of NHBD lungs by EVLP entails the inhibition of NKT cell activation, epithelial cell activation and neutrophil infiltration. This project addresses two major problems that plague lung transplantation: far too few suitable lungs ..
  48. Accelerating Inflammation Resolution to CounterACT Chemical Injury
    Sven Eric Jordt; Fiscal Year: 2013
    ..trigger a potent inflammatory response resulting in vascular leakage, cardiopulmonary depression, neutrophil infiltration and a pulmonary and systemic hypercytokinemia comparable to the cytokine storm observed in sepsis...
  49. Trauma to Developing Brain-Injury and Repair Mechanisms
    Linda J Noble; Fiscal Year: 2013
    ..an early self-perpetuating injury response that is coupled to activity of neutrophil elastase and neutrophil infiltration. We hypothesize that MMP-9 mediates early tissue damage by inactivating a1-protease inhibitor, the ..
  50. Disintegrin Metalloprotease and Endothelial Permeability
    Sarah Y Yuan; Fiscal Year: 2013
    ..that ADAM15 is upregulated in the lungs during bacterial infection or septic stimulation, contributing to neutrophil infiltration and pulmonary edema...
  51. Evasion of Innate Immunity by Group A Streptococcus
    Benfang Lei; Fiscal Year: 2013
    ..inhibition of early neutrophil recruitment by GAS;(2) Determine whether SsE mediates inhibition of early neutrophil infiltration via hydrolysis of platelet-activating factor;nd (3) Test whether streptolysin S is responsible for the ..
  52. Brain Injury and Alcohol: Neuropathological Mechanisms of Impaired Recovery
    XU SOPHIE TENG; Fiscal Year: 2013
    ..studies show a rapid increase of pro-inflammatory cytokine and chemokine expression at 6 h and enhanced neutrophil infiltration into the ipsilateral site of injury at 24 h post-TBI...
  53. Host-associated microbial communities role in innate immune system maturation
    ANNAH ROLIG; Fiscal Year: 2013
    ..responses to single bacterial species with immune responses to microbial communities I will examine gut neutrophil infiltration and host transcriptomes in gnotobiotic studies with one or two-member communities...
  54. CINC-1 as a modulator of blood-brain barrier integrity after neonatal stroke
    Zinaida Vexler; Fiscal Year: 2010
    ..contrast to the adult brain where disruption of the BBB occurs early and is mediated by chemokinedriven neutrophil infiltration into ischemic-reperfused tissue...
  55. Novel anti-bacterial therapy for gram negative pneumonia
    Kanneganti Murthy; Fiscal Year: 2001
    ..associated with a 90 percent reduction in bacterial cfu in the lung, a 95 percent decrease in pulmonary neutrophil infiltration, and a 50 percent reduction in the incidence of bacteremia...
  56. LIQUID VENTILATION IN ARDS
    Ronald Hirschl; Fiscal Year: 2000
    ..lung injury such as pulmonary capillary permeability, degree of intra-alveolar hemorrhage, and level of neutrophil infiltration and the relationship of these acute parameters to chronic markers of lung injury such as pulmonary ..
  57. Protection of Ocular Tissues During Inflammation
    MELVIN MEDOF; Fiscal Year: 2006
    ..regulators, DAF, and 2) obtained preliminary data in a bacterial keratitis model in this knockout that neutrophil infiltration and destruction of ocular tissues are dramatically increased...
  58. PARS inhibitor therapy for smoke inhalation
    Andrew Salzman; Fiscal Year: 2004
    ..a dramatic reduction in lung injury: INO-1001 markedly increased the PaO2/FiO2 (PF) ratio and decreased neutrophil infiltration, wet-to-dry ratio, and lung lymph flow...
  59. PARS inhibitor therapy of smoke inhalation injury
    Prakash Jagtap; Fiscal Year: 2001
    ..of PJ-34 on a comprehensive series of inflammatory indices of lung injury to assess lipid peroxidation, neutrophil infiltration, histology, and peroxynitrite formation...
  60. Novel xanthine oxidase inhibitor for arthritis
    Zsuzsanna Zsengeller; Fiscal Year: 2004
    ..inhibitor, AN-260, has been shown to abolish histologic injury in a DSS model of colitis and to prevent neutrophil infiltration and pro-inflammatory gene expression in an LPS model of ARDS...
  61. Molecular regulation of immune complex disease
    Joerg Koehl; Fiscal Year: 2004
    ..experimental model of soluble IC disease is the Arthus reaction, characterized by edema, hemorrhage and neutrophil infiltration. Activating Fc-gammaR and the complement cleavage product C5a receptor (C5aR) are essential to the ..
  62. Molecular regulation of immune complex disease
    Joerg Koehl; Fiscal Year: 2009
    ..experimental model of soluble IC disease is the Arthus reaction, characterized by edema, hemorrhage and neutrophil infiltration. Activating FcgammaR and the complement cleavage product C5a receptor (C5aR) are essential to the ..
  63. MURINE MODELS OF OCCUPATIONAL COPD
    GEORGE LEIKAUF; Fiscal Year: 2001
    ..for the study of acrolein-induced COPD, (2) To further investigate the role of macrophage/monocyte or neutrophil infiltration in mucus hypersecretion, and (3) To begin to investigate the genetic determinants of individual ..
  64. BETA2 INTEGRIN SIGNALING IN HUMAN NEUTROPHILS
    Mimi Takami; Fiscal Year: 2003
    ..of the mucosal injury in these disease processes has been directly correlated with the extent of the neutrophil infiltration. In addition, the persistent neutrophil infiltrate which is the hallmark of chronic H...
  65. Oral Antioxidant/Anticytokine Therapy for ALD
    Daniell Hill; Fiscal Year: 2005
    ..oxygen intermediates, activation of NFKB, increased TNF production, increased IL-8 production with neutrophil infiltration, Adomet deficiency, mitochondrial GSH depletion, increased susceptibility to hepatic TNF cytotoxicity, ..
  66. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..The factors which mediates initial neutrophil infiltration will be examined via infection of MMP-9-/- mice...