neutrophil activation

Summary

Summary: The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.

Top Publications

  1. ncbi Neutrophil extracellular traps kill bacteria
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Science 303:1532-5. 2004
  2. ncbi Neutrophils and acute lung injury
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 31:S195-9. 2003
  3. ncbi An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps
    Katharina Beiter
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna SE 171 82, Sweden
    Curr Biol 16:401-7. 2006
  4. ncbi Tumor-derived macrophage migration inhibitory factor modulates the biology of head and neck cancer cells via neutrophil activation
    Claudia A Dumitru
    Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
    Int J Cancer 129:859-69. 2011
  5. ncbi DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps
    John T Buchanan
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA
    Curr Biol 16:396-400. 2006
  6. pmc A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation
    Xin Xu
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e15781. 2011
  7. ncbi Neutrophil activation and acute lung injury
    W L Lee
    Division of Respirology, Department of Medicine and Critical Care Medicine Program, University of Toronto, Ontario, Canada
    Curr Opin Crit Care 7:1-7. 2001
  8. ncbi Widespread coronary inflammation in unstable angina
    Antonino Buffon
    Institute of Cardiology, Catholic University, Rome
    N Engl J Med 347:5-12. 2002
  9. ncbi The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation
    Tsong Long Hwang
    Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
    Biochem Pharmacol 80:1190-200. 2010
  10. ncbi PI3Kβ plays a critical role in neutrophil activation by immune complexes
    Suhasini Kulkarni
    Inositide Laboratory, The Babraham Institute, Cambridge CB22 3AT, UK
    Sci Signal 4:ra23. 2011

Detail Information

Publications332 found, 100 shown here

  1. ncbi Neutrophil extracellular traps kill bacteria
    Volker Brinkmann
    Microscopy Core Facility, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Science 303:1532-5. 2004
    ..NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria...
  2. ncbi Neutrophils and acute lung injury
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 31:S195-9. 2003
    ..This discussion aims to review the contribution of neutrophils to the development and progression of ALI and to highlight the major intracellular signaling pathways that are involved in neutrophil activation in the setting of ALI.
  3. ncbi An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps
    Katharina Beiter
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna SE 171 82, Sweden
    Curr Biol 16:401-7. 2006
    ..Furthermore, we demonstrate that escaping NETs promotes spreading of pneumococci from the upper airways to the lungs and from the lungs into the bloodstream during pneumonia...
  4. ncbi Tumor-derived macrophage migration inhibitory factor modulates the biology of head and neck cancer cells via neutrophil activation
    Claudia A Dumitru
    Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
    Int J Cancer 129:859-69. 2011
    ..In conclusion, our data indicate that the effects of tumor-derived MIF on neutrophils represent an additional mechanism by which MIF might contribute to tumor progression...
  5. ncbi DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps
    John T Buchanan
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA
    Curr Biol 16:396-400. 2006
    ..The results demonstrate a significant role for NETs in neutrophil-mediated innate immunity, and at the same time identify a novel therapeutic target against invasive GAS infection...
  6. pmc A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation
    Xin Xu
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e15781. 2011
    ..MMP-9 is present in the granules of PMNs and is differentially released during inflammation but whether Ac-PGP contributes to this ongoing proteolytic activity in chronic neutrophilic inflammation is currently unknown...
  7. ncbi Neutrophil activation and acute lung injury
    W L Lee
    Division of Respirology, Department of Medicine and Critical Care Medicine Program, University of Toronto, Ontario, Canada
    Curr Opin Crit Care 7:1-7. 2001
    ..Recent studies have focused on the intracellular signaling pathways that govern neutrophil activation and have elucidated complex cascades of kinases and other intracellular signaling molecules that allow for ..
  8. ncbi Widespread coronary inflammation in unstable angina
    Antonino Buffon
    Institute of Cardiology, Catholic University, Rome
    N Engl J Med 347:5-12. 2002
    ..In unstable angina, activated leukocytes may be found in peripheral and coronary-sinus blood, but it is unclear whether they are selectively activated in the vascular bed of the culprit stenosis...
  9. ncbi The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation
    Tsong Long Hwang
    Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
    Biochem Pharmacol 80:1190-200. 2010
    ..Taken together, our results demonstrate that SMG-1 is a natural inhibitor of the FMLP receptor, which may have the potential to be developed into a useful new therapeutic agent for treating neutrophilic inflammatory diseases...
  10. ncbi PI3Kβ plays a critical role in neutrophil activation by immune complexes
    Suhasini Kulkarni
    Inositide Laboratory, The Babraham Institute, Cambridge CB22 3AT, UK
    Sci Signal 4:ra23. 2011
    ..These results define PI3Kβ as a potential therapeutic target in inflammatory disease...
  11. pmc Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury
    Patricia Redecha
    Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Blood 110:2423-31. 2007
    ..The identification of TF as an important mediator of C5a-induced oxidative burst in neutrophils in aPL-induced fetal injury provides a new target for therapy to prevent pregnancy loss in the antiphospholipid syndrome...
  12. pmc Porphyromonas gingivalis participates in pathogenesis of human abdominal aortic aneurysm by neutrophil activation. Proof of concept in rats
    Sandrine Delbosc
    Institut National de la Santé et de la Recherche Médicale U698, Paris, France
    PLoS ONE 6:e18679. 2011
    ..We postulated that neutrophil recruitment and activation participating in AAA growth may originate in part from repeated episodes of periodontal bacteremia...
  13. pmc Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins
    Denise Lau
    Departments of Cardiology, Hepatobiliary Surgery, and Clinical Chemistry, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 102:431-6. 2005
    ..These cytokine-like properties of MPO thus represent an additional dimension of the proinflammatory actions of MPO in vascular disease...
  14. ncbi Neutrophil activation is attenuated by high-density lipoprotein and apolipoprotein A-I in in vitro and in vivo models of inflammation
    Andrew J Murphy
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Arterioscler Thromb Vasc Biol 31:1333-41. 2011
    ..High-density lipoproteins (HDL) are antiinflammatory particles, exerting beneficial cardiovascular influences. We determined whether HDL exerts antiinflammatory effects on neutrophils and explored the mechanisms by which these occur...
  15. pmc Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Am J Pathol 170:52-64. 2007
    ....
  16. ncbi TNF-alpha induces phosphorylation of p47(phox) in human neutrophils: partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony-stimulating factor
    Cedric Dewas
    Institut National de la Santé et de la Recherche Médicale Unité 479, Faculte de Medecine Xavier Bichat, Paris, France
    J Immunol 171:4392-8. 2003
    ....
  17. ncbi Neutrophil activation, antioxidant supplements and exercise-induced oxidative stress
    Jonathan Peake
    School of Human Sciences and Consolidated Research Institute for Advanced Science and Medical Care, Waseda University
    Exerc Immunol Rev 10:129-41. 2004
    ..A small number of studies have investigated whether there is a link between neutrophil activation and oxidative stress during exercise. In this review, we have summarised the findings of these studies...
  18. ncbi Regulation of human neutrophil granule protein expression
    N Borregaard
    Department of Hematology, Rigshospitalet, University of Copenhagen, Denmark
    Curr Opin Hematol 8:23-7. 2001
    ..1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein expression...
  19. pmc Shear-induced resistance to neutrophil activation via the formyl peptide receptor
    Michael J Mitchell
    Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA
    Biophys J 102:1804-14. 2012
    ..The role of shear forces on earlier indicators of neutrophil activation, such as L-selectin shedding and α(M)β(2) integrin activation, remains unclear...
  20. ncbi Effect of acetate-free biofiltration and bicarbonate hemodialysis on neutrophil activation
    Marta Todeschini
    Mario Negri Institute for Pharmacological Research, Clinical Research Center for Rare Diseases, Aldo e Cele Daccò, Villa Camozzi Ranica, BG, Italy
    Am J Kidney Dis 40:783-93. 2002
    ..Acetate-free biofiltration (AFB) has been shown to cause less monocyte activation and cytokine release than bicarbonate HD (BHD). No data are available to date on the effect of AFB on PMN activation...
  21. ncbi Complement alternative pathway acts as a positive feedback amplification of neutrophil activation
    Laurent Camous
    INSERM U845, Universite Rene Descartes, Hopital Necker, 161 rue de Sevres, Paris, France
    Blood 117:1340-9. 2011
    ..Complement-induced neutrophil activation involved mostly C5a and possibly C5b-9 complexes, detected on tumor necrosis factor- and serum-activated ..
  22. ncbi A methodological approach to studies of desensitization of the formyl peptide receptor: Role of the read out system, reactive oxygen species and the specific agonist used to trigger neutrophils
    Jennie Karlsson
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Guldhedsgatan 10, 413 46 Goteborg, Sweden
    J Immunol Methods 352:45-53. 2010
    ....
  23. ncbi IL-18 is upregulated in the kidney and primes neutrophil responsiveness in ANCA-associated vasculitis
    P Hewins
    Renal Immunobiology, Medical School, University of Birmingham, Birmingham, UK
    Kidney Int 69:605-15. 2006
    In antineutrophil cytoplasm autoantibody (ANCA)-associated systemic vasculitis (ASV), autoantibody-induced neutrophil activation is believed to cause organ damage...
  24. ncbi Microparticles initiate decompression-induced neutrophil activation and subsequent vascular injuries
    Stephen R Thom
    Institute for Environmental Medicine, Univ of Pennsylvania, 1 John Morgan Bldg, 3620 Hamilton Walk, Philadelphia, PA 19104 6068, USA
    J Appl Physiol (1985) 110:340-51. 2011
    ..Both MP abatement strategies reduce decompression-induced intravascular neutrophil activation, neutrophil sequestration, and tissue injury documented as elevations of vascular permeability and ..
  25. ncbi Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines
    Irundika H K Dias
    School of Life and Health Sciences, Aston University, Birmingham, UK
    J Clin Periodontol 38:1-7. 2011
    ..To determine the effect of periodontitis patients' plasma on the neutrophil oxidative burst and the role of albumin, immunoglobulins (Igs) and cytokines...
  26. ncbi Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
    Constantin F Urban
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    Cell Microbiol 8:668-76. 2006
    ..We demonstrate that NETs kill both yeast-form and hyphal cells, and that granule components mediate fungal killing. Taken together our data indicate that neutrophils trap and kill ascomycetous yeasts by forming NETs...
  27. ncbi Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD
    A Di Stefano
    Division of Pulmonary Disease and Laboratory of Cytoimmunopathology of Heart and Lung, Salvatore Maugeri Foundation, IRCCS, Veruno, Italy
    Thorax 64:968-75. 2009
    ..Increased numbers of activated neutrophils have been reported in the bronchial mucosa of patients with stable chronic obstructive pulmonary disease (COPD), particularly in severe disease...
  28. pmc Enhanced neutrophil response in chronic obstructive pulmonary disease
    A Noguera
    Serveis de Analisis Cliniques, Hospital Universitari Son Dureta, Palma de Mallorca, Spain
    Thorax 56:432-7. 2001
    ..These findings support those of other studies which have indicated that the neutrophil is likely to play a major role in the pathogenesis of this disease...
  29. ncbi The role of neutrophils during intestinal inflammation
    B M Fournier
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Mucosal Immunol 5:354-66. 2012
    ..In this article, we summarize the beneficial and deleterious roles of neutrophils in the intestine during health and disease and provide an overview of what is known about neutrophil function in the gut...
  30. pmc C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis
    Adrian Schreiber
    Medical Faculty of the Charite, Department of Nephrology and Hypertension, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin, Berlin, Germany
    J Am Soc Nephrol 20:289-98. 2009
    ..05). In summary, C5a and the neutrophil C5aR may compose an amplification loop for ANCA-mediated neutrophil activation. The C5aR may provide a new therapeutic target for ANCA-induced necrotizing crescentic glomerulonephritis.
  31. pmc Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function
    Sarah L Farnworth
    Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Am J Pathol 172:395-405. 2008
    ....
  32. ncbi Extracellular acidification induces human neutrophil activation
    A S Trevani
    Laboratory of Immunology, Institute of Hematologic Research, National Academy of Medicine, Buenos Aires University School of Medicine, Argentina
    J Immunol 162:4849-57. 1999
    ..A role for intracellular acidification in neutrophil activation is suggested by the fact that only neutrophils suspended in bicarbonate-buffered media (i.e...
  33. ncbi Haemophilus influenzae induces neutrophil necrosis: a role in chronic obstructive pulmonary disease?
    Emma J Naylor
    School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Am J Respir Cell Mol Biol 37:135-43. 2007
    ..However, the infiltrating neutrophils fail to kill the bacteria and instead release tissue-damaging products into the lung as they undergo necrosis. These results may help to explain the clinical picture in COPD...
  34. ncbi Fish cast NETs: neutrophil extracellular traps are released from fish neutrophils
    Dušan Palić
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
    Dev Comp Immunol 31:805-16. 2007
    ..Detection of NETs can be used as an additional assay to an existing battery of functional tests, and as a new research model to study the effects of stress, immunomodulators, and diseases...
  35. ncbi Protein kinase C isoforms in neutrophil adhesion and activation
    Anna Bertram
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Arch Immunol Ther Exp (Warsz) 59:79-87. 2011
    ..This review focuses on the potential impact of protein kinase C isoforms on neutrophil adhesion and activation...
  36. ncbi Changes in expression of membrane TNF, NF-{kappa}B activation and neutrophil apoptosis during active and resolved inflammation
    Helen L Wright
    Biosciences Building, Crown Street, University of Liverpool, Liverpool L69 7ZB, UK
    Ann Rheum Dis 70:537-43. 2011
    ..Tumour necrosis factor (TNF) is central to the pathophysiological process of rheumatoid arthritis (RA), whether as soluble cytokine or membrane-expressed pro-TNF (mTNF)...
  37. ncbi Proinflammatory effects of bacterial lipoprotein on human neutrophil activation status, function and cytotoxic potential in vitro
    C Power
    Department of Academic Surgery, Cork University Hospital, Wilton, Ireland
    Shock 15:461-6. 2001
    ..BLP far exceeds LPS as a gram-negative bacterial wall component, these findings therefore implicate BLP as an additional putative mediator of SIRS arising from gram-negative infection...
  38. pmc Neutrophil serine proteases fine-tune the inflammatory response
    Christine T N Pham
    Division of Rheumatology, Department of Internal Medicine, Washington University, 660 South Euclid Avenue, Box 8045, St Louis, MO 63110, USA
    Int J Biochem Cell Biol 40:1317-33. 2008
    ..Their extracellular release upon neutrophil activation is traditionally regarded as the primary reason for tissue damage at the sites of inflammation...
  39. ncbi Extracellular neutrophil traps in periodontitis
    L Vitkov
    Department of Operative Dentistry and Periodontology, Saarland University, Homburg, Germany
    J Periodontal Res 44:664-72. 2009
    ..Recently, a 'new' extracellular neutrophil defense mechanism - neutrophil extracellular traps - has been described. However, their role in periodontitis has not yet been investigated...
  40. ncbi The systemic inflammatory response induced by trauma is reflected by multiple phenotypes of blood neutrophils
    J Pillay
    Department of Respiratory Medicine, University Medical Center Utrecht, The Netherlands
    Injury 38:1365-72. 2007
    ..This article reviews the application of these specific signatures of neutrophil receptors as a consequence of severe injury...
  41. ncbi Early alterations in neutrophil activation are associated with outcome in acute lung injury
    Kuang Yao Yang
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Mail Code C 272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Am J Respir Crit Care Med 167:1567-74. 2003
    ..These results suggest that early alterations in neutrophil activation patterns, particularly involving the ability to accumulate NF-kappaB to the nucleus after relevant stimuli,..
  42. ncbi Bubbles, microparticles, and neutrophil activation: changes with exercise level and breathing gas during open-water SCUBA diving
    Stephen R Thom
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Appl Physiol (1985) 114:1396-405. 2013
    ..enriched air nitrox) would alter annexin V-positive microparticle (MP) production and size changes and neutrophil activation, as well as their relationships to intravascular bubble formation...
  43. ncbi Decreased activity of neutrophils in the presence of diferuloylmethane (curcumin) involves protein kinase C inhibition
    Viera Jancinova
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska cesta 9, 84104 Bratislava, Slovakia
    Eur J Pharmacol 612:161-6. 2009
    ..As neutrophils are considered to be cells with the greatest capacity to inflict damage within diseased joints, the observed effects could represent a further mechanism involved in the antirheumatic activity of diferuloylmethane...
  44. ncbi Integrins and cytokines activate nuclear transcription factor-kappaB in human neutrophils
    Ralph Kettritz
    Medical Faculty of the Charite, Department of Nephrology and Hypertension, Franz Volhard Clinic, Helios Klinikum Berlin and Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany
    J Biol Chem 279:2657-65. 2004
    ..Adhesion may accelerate neutrophil activation by affecting intracellular signaling pathways...
  45. pmc Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation
    Emily J Welch
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Mol Pharmacol 75:227-34. 2009
    ..These findings identify lysoPAF as a bioactive lipid with opposing functions of PAF and suggest a novel and intrinsic regulatory mechanism for balance of the potent activity of PAF...
  46. ncbi A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1
    Cristina Prat
    Eijkman Winkler Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Immunol 177:8017-26. 2006
    ..aureus infections. As a novel described FPRL1 antagonist, it might lead to the development of therapeutic agents in FPRL1-mediated inflammatory components of diseases such as systemic amyloidosis, Alzheimer's, and prion disease...
  47. ncbi Mycobacterium tuberculosis 19-kDa lipoprotein promotes neutrophil activation
    C Neufert
    Department of Pathology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Immunol 167:1542-9. 2001
    ..MTB 19-kDa lipoprotein initiated phenotypic changes characteristic of neutrophil activation, including down-regulation of CD62 ligand (L-selectin) and up-regulation of CD35 (CR1) and CD11b/CD18 (CR3,..
  48. ncbi Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo
    R K Kharbanda
    Centre for Clinical Pharmacology and Therapeutics, University College London, London, UK
    Circulation 103:1624-30. 2001
    ..We studied the effects of experimental IR on endothelial and neutrophil function in the human forearm in vivo and examined the protection afforded by IPC...
  49. pmc An intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes
    Norma Maugeri
    Università Vita Salute San Raffaele and San Raffaele Scientific Institute, Milano, Italy
    PLoS ONE 7:e39484. 2012
    Neutrophils are involved in thrombus formation. We investigated whether specific features of neutrophil activation characterize patients with acute coronary syndromes (ACS) compared to stable angina and to systemic inflammatory diseases.
  50. ncbi Glucagon-like peptide-1 (GLP-1), immediately prior to reperfusion, decreases neutrophil activation and reduces myocardial infarct size in rodents
    B B Dokken
    Department of Medicine, University of Arizona, Tuscon, USA
    Horm Metab Res 43:300-5. 2011
    ..52±0.31 vs. GLP-1 4.78±0.90, TFI, p<0.05). These findings suggest that one mechanism by which GLP-1 decreases reperfusion injury may be the attenuation of PMN-mediated reperfusion injury...
  51. pmc Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation
    Uwe Jerke
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Berlin, Germany
    J Biol Chem 286:7070-81. 2011
    ..an intracellular domain, we characterized components of the NB1 signaling complex that are pivotal for neutrophil activation. PR3-ANCA resulted in degranulation and superoxide production in the mNB1(pos)/PR3(high) neutrophils, but ..
  52. ncbi Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity
    Daniel R Ambruso
    Bonfils Blood Center, Denver, CO 80230, USA
    Biochim Biophys Acta 1823:306-15. 2012
    ..Prdx6 supports retention of the active oxidase complex in stimulated plasma membrane, and results with mutant proteins imply that Prdx6 serves an additional biochemical or structural role in supporting optimal NADPH oxidase activity...
  53. ncbi Downmodulation of CXCL8/IL-8 receptors on neutrophils after recruitment in the airways
    Patrizia Pignatti
    Servizio Autonomo di Allergologia e Immunologia Clinica, Fondazione Salvatore Maugeri, IRCCS, Pavia, Italy
    J Allergy Clin Immunol 115:88-94. 2005
    ..CXCL8/IL-8 is the most significant chemokine for neutrophils, and CXC chemokine receptor (CXCR) 1 and 2 are its 2 receptors, which are downmodulated by CXCL8/IL-8 and endotoxin on activated neutrophils...
  54. pmc LPS-induced galectin-3 oligomerization results in enhancement of neutrophil activation
    Marise Lopes Fermino
    Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    PLoS ONE 6:e26004. 2011
    ..domain or via its N-terminal part, with LPS from different bacterial strains, enhances the LPS-mediated neutrophil activation in vitro...
  55. ncbi IL-33 induces skin inflammation with mast cell and neutrophil activation
    Axel J Hueber
    Glasgow Biomedical Research Centre, University of Glasgow, UK
    Eur J Immunol 41:2229-37. 2011
    ..These results therefore demonstrate that IL-33 may play a role in psoriasis-like plaque inflammation. IL-33 targeting may provide a new treatment strategy for psoriasis...
  56. ncbi A rapid assay of endotoxin in whole blood using autologous neutrophil dependent chemiluminescence
    A D Romaschin
    Department of Clinical Biochemistry, The Toronto Hospital, University of Toronto, Ontario, Canada
    J Immunol Methods 212:169-85. 1998
    ..This was reproducible over a wide range of LPS concentrations (0.017-1.6 EU/ml or 20-2000 pg/ml). This assay may be a clinically useful tool for the diagnosis of infection or endotoxin in patients...
  57. pmc SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans
    Aili L Lazaar
    COPD Clinical Discovery, GlaxoSmithKline, King of Prussia, PA, USA
    Br J Clin Pharmacol 72:282-93. 2011
    ..A CXCR1/2 receptor antagonist has shown activity in an ozone challenge model in humans...
  58. ncbi Role of interleukin-8 in neutrophil signaling
    H U Zeilhofer
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    Curr Opin Hematol 7:178-82. 2000
    ....
  59. ncbi Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis
    Matthias Lange
    Investigational Intensive Care Unit, Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 37:468-72. 2012
    ....
  60. pmc The elevation in circulating anti-angiogenic factors is independent of markers of neutrophil activation in preeclampsia
    Wenda Ramma
    University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Angiogenesis 15:333-40. 2012
    Severe preeclampsia is associated with increased neutrophil activation and elevated serum soluble endoglin (sEng) and soluble Flt-1 (sFlt-1) in the maternal circulation...
  61. ncbi Neutrophil activation induced by the lectin KM+ involves binding to CXCR2
    Gabriela Pereira-da-Silva
    Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Biochim Biophys Acta 1760:86-94. 2006
    ..These results suggest that the KM+ ligand on the neutrophil surface is a G protein-coupled receptor (GPCR). The results also suggest that neutrophil migration induced by KM+ involves binding to CXCR2...
  62. pmc p38MAPK, ERK and PI3K signaling pathways are involved in C5a-primed neutrophils for ANCA-mediated activation
    Jian Hao
    Renal Division, Key Laboratory of Renal Disease, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Ministry of Health of China, Beijing, China
    PLoS ONE 7:e38317. 2012
    ..The current study further investigated the signaling pathways of C5a-mediated priming of human neutrophils for ANCA-induced neutrophil activation.
  63. ncbi Maternal protein restriction during early lactation induces changes on neutrophil activation and TNF-alpha production of adult offspring
    Simone V Silva
    Departamento de Farmacologia, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av 28 de setembro 87 fds, Vila Izabel, Rio de Janeiro, 20551 030, RJ, Brazil
    Inflammation 33:65-75. 2010
    ..The data indicate that maternal nutritional stress can interfere on the innate immune response in adulthood, imprinting permanent alterations on cytokine production and neutrophil activation.
  64. ncbi Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways
    Gabriela C Fernandez
    Division Inmunologia, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
    Glycobiology 15:519-27. 2005
    ....
  65. ncbi Neutrophil extracellular traps contain mitochondrial as well as nuclear DNA and exhibit inflammatory potential
    Ravi S Keshari
    Pharmacology Division, CSIR Central Drug Research Institute, Lucknow 226 001, India
    Cytometry A 81:238-47. 2012
    ..These NETs were made up of mitochondrial and nuclear DNA and potentiated release of proinflammatory cytokines...
  66. ncbi ADAM17 activity during human neutrophil activation and apoptosis
    Bruce Walcheck
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    Eur J Immunol 36:968-76. 2006
    ..activity, we examined its surface expression and the shedding of its substrates during extended periods of neutrophil activation and apoptosis...
  67. ncbi The effect of a short-term mental stressor on neutrophil activation
    D R Ellard
    Department of Biomedical Sciences, School of Natural and Environmental Sciences Coventry University, Priory Street, Coventry, CV1 5FB, UK
    Int J Psychophysiol 41:93-100. 2001
    ..In contrast, the control group's neutrophils showed no significant change in activation throughout. The results support the hypothesis that short-term, acute stressors may activate neutrophils...
  68. ncbi p38 Mitogen-activated protein kinase signaling regulates streptococcal M1 protein-induced neutrophil activation and lung injury
    Songen Zhang
    Section for Surgery, Malmo University Hospital, Malmo, Sweden
    J Leukoc Biol 91:137-45. 2012
    ..In conclusion, these findings suggest that targeting the p38 MAPK signaling pathway may open new opportunities to protect against lung injury in streptococcal infections...
  69. pmc Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 110:955-63. 2002
    ..This animal model offers strong support for a direct pathogenic role for ANCA IgG in human glomerulonephritis and vasculitis...
  70. ncbi Crystal-induced neutrophil activation
    Oana Popa-Nita
    Centre de Recherche en Rhumatologie et Immunologie du Centre de Recherche du CHUL CHUQ, Department of Microbiology and Immunology, Faculty of Medicine, Laval University, Quebec, Canada
    Immunol Cell Biol 88:32-40. 2010
    ..A non-exhaustive list of the most important questions that remain to be assessed to further describe the physio-pathological mechanisms of gouty arthritis is presented here...
  71. ncbi Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature
    M L Bajt
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1188-95. 2001
    ..of our study was to compare the efficacy of systemic exposure with individual inflammatory mediators on neutrophil activation and sequestration in the hepatic vasculature of C3Heb/FeJ mice as assessed by flow cytometry and ..
  72. ncbi The involvement of nitric oxide, nitric oxide synthase, neutrophil elastase, myeloperoxidase and proinflammatory cytokines in the acute lung injury caused by phorbol myristate acetate
    Yi Ling Yang
    Institute of Biotechnology, National Chia Yi University, Chiayi, Taiwan
    J Biomed Sci 15:499-507. 2008
    ..PMA upregulated the expression of iNOS mRNA. Our results suggest that neutrophil activation by PMA causes release of NE, upregulation of iNOS and a series of inflammatory responses leading to ..
  73. pmc Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease
    E Fortunati
    Department of Pulmonary Diseases, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Exp Immunol 155:559-66. 2009
    ..In conclusion, our data indicate that neutrophils found in the lung exhibit an activated phenotype under both homeostatic and inflammatory conditions...
  74. ncbi Preeclampsia activates circulating immune cells with engagement of the NF-kappaB pathway
    Patrizia Luppi
    Division of Immunogenetics, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, PA 15213, USA
    Am J Reprod Immunol 56:135-44. 2006
    ..Here, we investigated activation in additional leukocyte populations among women with preeclampsia...
  75. ncbi Human neutrophil lipocalin: a specific marker for neutrophil activation in severe Plasmodium falciparum malaria
    Abdelrahim O Mohammed
    Department of Biochemistry, Faculty of Medicine, University of Khartoum, Box 102 Khartoum, Sudan
    Acta Trop 87:279-85. 2003
    We have earlier indicated neutrophil activation in severe malaria by measuring myeloperoxidase (MPO) and lysozyme, leukocyte granule proteins secreted by neutrophils as well as by other blood cells (monocytes/macrophages)...
  76. ncbi IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture
    Susana E Moreno
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Immunol 177:3218-24. 2006
    ..Our data therefore provide further insight into the defense mechanism against this critical area of infectious disease...
  77. ncbi Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1
    Lisa J Crossley
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Leukoc Biol 74:583-92. 2003
    ..These studies show that fMLP-stimulated neutrophils coordinate the regulation of FOXO transcription factors and the survival factor Mcl-1, a mechanism that may allow neutrophils to alter their survival...
  78. ncbi Ranitidine reduces ischemia/reperfusion-induced liver injury in rats by inhibiting neutrophil activation
    Kenji Okajima
    Department of Laboratory Medicine, Kumamoto University School of Medicine, Honjo 1 1 1, Kumamoto 860 0811, Japan
    J Pharmacol Exp Ther 301:1157-65. 2002
    We previously reported that ranitidine, an H(2) receptor antagonist, inhibited neutrophil activation in vitro and in vivo, contributing to reduce stress-induced gastric mucosal injury in rats...
  79. ncbi Fibrinogen promotes neutrophil activation and delays apoptosis
    C Rubel
    Division Inmunologia, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
    J Immunol 166:2002-10. 2001
    ..In parallel, neutrophil activation is thought to play a crucial role in several inflammatory conditions, and it has been recently ..
  80. ncbi Severe meningococcal disease is characterized by early neutrophil but not platelet activation and increased formation and consumption of platelet-neutrophil complexes
    M J Peters
    Infection and Microbiology Unit and Portex Unit Critical Care Group, Institute of Child Health, London, United Kingdom
    J Leukoc Biol 73:722-30. 2003
    ..Therefore, in severe MD, PMNL activation is likely to promote PNC formation, and we suggest that the reduced levels of PNC seen in established MD reflect rapid loss of PNC from the circulation rather than reduced formation...
  81. ncbi Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNFalpha-dependent and Fc-receptor-independent way
    Sven Jarius
    Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany
    Blood 109:4376-82. 2007
    ..To elucidate the potential role of neutrophil activation, we analyzed IVIg preparations from 5 different commercial sources for the presence of antineutrophil ..
  82. ncbi Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration
    Kristin N Kornerup
    Sackler Institute of Pulmonary Pharmacology and Therapeutics, Division of Pharmaceutical Sciences, School of Biomedical and Health Sciences, King s College, London, UK
    J Appl Physiol (1985) 109:758-67. 2010
    ..that low-dose prothrombotic and pro-inflammatory stimuli (CCL17 or CCL22) synergize to induce platelet and neutrophil activation, as well as the formation of platelet-neutrophil conjugates...
  83. ncbi Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction
    T L Wang
    Department of Emergency Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Cardiovasc Res 40:557-63. 1998
    Previous results from our laboratory have suggested that morphine can attenuate neutrophil activation in patients with acute myocardial infarction...
  84. ncbi Serum levels of neutrophil activation cytokines in Kawasaki disease
    H Suzuki
    Department of Pediatrics, Wakayama Medical University, Wakayama, Japan
    Pediatr Int 43:115-9. 2001
    ..damage in the acute phase of Kawasaki disease (KD) by examining serial changes in neutrophil counts and serum levels of neutrophil activation cytokines, such as granulocyte colony stimulating factor (G-CSF) and interleukin (IL)-8.
  85. ncbi Exercise-induced muscle damage, plasma cytokines, and markers of neutrophil activation
    Jonathan M Peake
    School of Human Movement Studies, University of Queensland, St Lucia, Brisbane, Queensland, Australia
    Med Sci Sports Exerc 37:737-45. 2005
    Unaccustomed eccentric exercise often results in muscle damage and neutrophil activation. We examined changes in plasma cytokines stress hormones, creatine kinase activity and myoglobin concentration, neutrophil surface receptor ..
  86. ncbi Participation of superoxide in neutrophil activation and cytokine production
    Sanchayita Mitra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver and Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Biochim Biophys Acta 1762:732-41. 2006
    ..However, the effects of ROS can differ in various cell populations. To examine the role of superoxide in neutrophil activation, we exposed resting neutrophils and neutrophils stimulated with LPS to paraquat, an agent that ..
  87. ncbi Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury
    H K Yum
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 167:6601-8. 2001
    ..These results show that PI3-K, and particularly PI3-Kgamma, occupies a central position in regulating endotoxin-induced neutrophil activation, including that involved in ALI.
  88. ncbi Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps
    S Yousefi
    Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
    Cell Death Differ 16:1438-44. 2009
    ..In conclusion, mitochondrial DNA release by neutrophils and NET formation do not require neutrophil death and do also not limit the lifespan of these cells...
  89. ncbi Activation of human neutrophils by titanium dioxide (TiO2) nanoparticles
    D M Gonçalves
    Laboratoire de recherche en inflammation et physiologie des granulocytes, Universite du Quebec, INRS Institut Armand Frappier, Laval, QC, Canada
    Toxicol In Vitro 24:1002-8. 2010
    ..The increased production of IL-8 was confirmed by ELISA. We conclude that TiO(2) exerts important neutrophil agonistic properties in vitro...
  90. ncbi Neutrophil activation in morbid obesity, chronic activation of acute inflammation
    Jeroen Nijhuis
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of General Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Obesity (Silver Spring) 17:2014-8. 2009
    Recent studies show that morbid obesity is associated with activation of the innate immune response. Neutrophil activation is a fundamental process in the innate immune response...
  91. ncbi The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins
    Sang Hyun Kwak
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 78:937-45. 2005
    ..These results demonstrate that the KD of uPA, through interaction with alpha(V)beta(3) integrins, potentiates neutrophil activation.
  92. pmc In vivo models of lung neutrophil activation. Comparison of mice and hamsters
    Randolph Corteling
    Novartis Respiratory Research Centre, Horsham, UK
    BMC Pharmacol 2:1. 2002
    ..In the present study, we describe in vivo models of lung neutrophil infiltration and activation in mice and hamsters...
  93. pmc Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury
    Jaroslaw W Zmijewski
    Department of Medicine, University of Alabama at Birmingham School of Medicine, 1530 Third Avenue S, Birmingham, AL 35294 0012, USA
    Am J Respir Crit Care Med 178:168-79. 2008
    ....
  94. pmc Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation
    Yan Zheng
    Department of Dermatology, Atopy Allergy Research Centre, Juntendo University School of Medicine, Tokyo, Japan
    Immunology 124:357-67. 2008
    ..and chemokines as evidenced by the inhibitory effects of p38 and ERK inhibitors on psoriasin-mediated neutrophil activation. Moreover, psoriasin stimulates the generation of reactive oxygen species from neutrophils, most likely ..
  95. pmc Purinergic signaling: a fundamental mechanism in neutrophil activation
    Yu Chen
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Sci Signal 3:ra45. 2010
    ..with P2Y2 nucleotide receptors on the cell surface to form a purinergic signaling system that facilitated neutrophil activation. Disruption of this purinergic signaling system by inhibiting or silencing panx1 hemichannels or P2Y2 ..
  96. ncbi Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: novel pathways for tertiary granule release
    Subhadeep Chakrabarti
    Department of Physiology and Biophysics, Immunology Research Group, University of Calgary, Alberta, Canada
    J Leukoc Biol 79:214-22. 2006
    ..These data suggest that MMP-9 release from tertiary granules uses beta2-integrin-independent signaling pathways. Furthermore, PKC isoforms play a critical role in regulating tertiary granule release...
  97. ncbi Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils
    Izumi Kikuchi
    Department of Respiratory Medicine, Saitama Medical School, Saitama, Japan
    Am J Respir Cell Mol Biol 34:760-5. 2006
    ..These results suggest that neutrophils migrated in response to IL-8 may lead eosinophils to accumulate in the airways of asthma and possibly aggravate this disease...
  98. ncbi Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein
    O Soehnlein
    Dept of Physiology and Pharmacology, Karolinska Institute, 17177 Stockholm, Sweden
    Eur Respir J 32:405-12. 2008
    ..Interestingly, the lung damage was restored by injecting neutrophil secretion. The present data suggest that neutrophil granule proteins are directly responsible for lung damage induced by the streptococcal M1 protein...
  99. ncbi Neutrophil activation and C-reactive protein concentration in preeclampsia
    Luis Belo
    Department of Biochemistry, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Hypertens Pregnancy 22:129-41. 2003
    ..In preeclampsia, a significant positive correlation was found between elastase and lactoferrin and these neutrophil activation products correlated positively with uric acid level...
  100. pmc Neutrophil activation status in stable coronary artery disease
    Eva Särndahl
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    PLoS ONE 2:e1056. 2007
    ..Our aim was to investigate the neutrophil activation status in patients with stable coronary artery disease (CAD) at conventional drug treatment.
  101. pmc The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival
    Lynne R Prince
    Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom
    Am J Pathol 165:1819-26. 2004
    The regulation of systemic and local neutrophil activation is crucial to the clearance of infections and the successful resolution of inflammation without progress to tissue damage or disseminated inflammatory reactions...

Research Grants62

  1. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..injury, APC, hyperglycemia and statins will be determined by evaluating vascular inflammatory responses (neutrophil activation) and cytokine generation before and after I/R injury...
  2. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2013
    ..as a means to delay the onset and decrease the severity and topographical heterogeneity of VILI-induced neutrophil activation in initially uninjured lungs ventilated with large tidal volume...
  3. Mechanism of Neutrophil Activation
    Kenneth R McLeish; Fiscal Year: 2013
    ..Thus, new approaches to treating Veteran patients with a number of acute and chronic inflammatory diseases are anticipated. ..
  4. Molecular Basis for Priming of the Neutrophil NADPH Oxidase in Trauma and Sepsis
    ALBERT T HSU; Fiscal Year: 2010
    ..Earlier work has suggested that there exists a direct correlation between the level of neutrophil activation in trauma patients and injury severity and prognosis...
  5. Regulation of neutrophil migration by Activated Protein C
    Minsoo Kim; Fiscal Year: 2010
    ..This is followed by neutrophil activation and directed migration to sites of infection through the extracellular matrix...
  6. Mechanisms of xenobiotic-induced biliary inflammation and fibrosis
    James P Luyendyk; Fiscal Year: 2013
    ..b>Neutrophil activation, bile duct injury and collagen deposition were significantly reduced in low TF mice, which express 1% of ..
  7. Mesenteric Lymph Linking Gut & Distant Organ Injury
    Edwin A Deitch; Fiscal Year: 2010
    ..indicating that T/HSinduced lung injury and endothelial cell activation/dysfunction (Project by Deitch), neutrophil activation (Project by Hauser), red blood cell dysfunction (Project by MachiedoI) and bone marrow failure (Project by ..
  8. Cardioprotective Efficacy ofMg-Supplementation during HAART Therapy
    IVAN TONG MAK; Fiscal Year: 2011
    ..AZT treatment in a rat model provoked systemic oxidative stress, neutrophil activation and inflammatory WBC infiltration of cardiac tissue;most intriguingly, all these oxidative indices were ..
  9. A novel therapeutic strategy for Acute Lung Injury: Inhibition of PKC-delta
    JOHN T SWINDLE; Fiscal Year: 2012
    ..In PKC[unreadable] null mice, neutrophil activation and migration are limited in response to pulmonary inflammation...
  10. Mechanisms of Neutrophil Activation
    Clifford A Lowell; Fiscal Year: 2013
    ..calcium entry" (SOCE) into cells is one of the major intracellular signaling responses that induce neutrophil activation. The molecular mechanism of SOCE has recently been defined through the identification of the intracellular ..
  11. Regulatory Pathways in Osteoclasts and Immune Cells during Inflammatory Arthritis
    Roberta Faccio; Fiscal Year: 2013
    ..Aim 2: Examine the role of DGK? in development and resolution of serum induced arthritis and its effect on neutrophil activation. Specific Aim 3: Determine the role of DGK? in antigen-induced arthritis and its effect in DC- mediated T ..
  12. Urokinase, Neutrophil Activation and Acute Lung Injury.
    Gang Liu; Fiscal Year: 2013
    ..of ALI independently of their effects on coagulation and fibrinolytic pathways: 1) by enhancing neutrophil activation and 2) by decreasing phagocytosis and clearance of neutrophils in the lungs...
  13. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard D Minshall; Fiscal Year: 2011
    ..We will assess the role of neutrophil activation of Src kinase in endothelial cells in regulating caveolin-1, dynamin-2, and eNOS function, and determine ..
  14. Neutrophil-epithelial interaction mediated by adenosine
    Didier Merlin; Fiscal Year: 2013
    ..disease (IBD);iii) A2BAR mediates apically polarized IL-6 and fibronectin secretion, which in turn mediate neutrophil activation and bacterial adhesion/invasion respectively;iv) A2BAR augments IL-8 secretion and mediates neutrophil ..
  15. Selective Cytopheresis Therapy in Systemic Inflammatory Response Syndrome
    Deborah A Buffington; Fiscal Year: 2013
    ..Various renal and cardiovascular parameters, pulmonary inflammation, cytokine levels, systemic neutrophil activation load and time to death will be compared between SCDG2 designs of varying SA and the SCDG1 (Aim 3)...
  16. Post-Transplant Inflammatory Response
    Robert L Fairchild; Fiscal Year: 2012
    ..donor-reactive memory CD8 T cells amplify this early neutrophil infiltration into the allograft and induce neutrophil activation in the allograft, and that this neutrophil activation results in changes, or "marking", of the allograft ..
  17. Identification and Analysis of the Physiological Ligand for TLT2
    Louis B Justement; Fiscal Year: 2013
    ..that TLT2 drives a positive feed-forward loop that involves the production of factors that modulate neutrophil activation and chemotaxis, and at the same time potentiates the neutrophil response to those factors (i.e...
  18. Neutrophil Decision Making in Confined Environments in Health and Disease
    Daniel Irimia; Fiscal Year: 2013
    ..While neutrophil activation is protective after minor trauma, hyper-active neutrophils after major injuries have systemic deleterious ..
  19. STEP UP In Health-related Research
    Raul DeLa Cadena; Fiscal Year: 2013
    ..Thrombosis Research Center which focuses on research related to platelet function, blood coagulation, neutrophil activation and fibrin formation, 2) the Cardiovascular Research Center with research related to the function of the ..
  20. EPCR, TAFI as Regulators of PMN/Endothelial Interaction
    Florea Lupu; Fiscal Year: 2009
    ..We postulate that TAFla (procarboxypeptidase beta) attenuates neutrophil activation by inactivating C5a, and that soluble EPCR attenuates subsequent tight binding of neutrophils to ..
  21. Novel Neutrophil Autoantigens in Systemic Lupus Erythematosus
    Kaihong Su; Fiscal Year: 2013
    ..Neutrophils are at the frontier of innate immunity against infections. Neutrophil activation has also been linked to tissue injury in acute infections and autoimmune conditions...
  22. Mechanisms of CD40/CD40L in vascular injury and repair
    Guohong Li; Fiscal Year: 2013
    ..Aim 3 will establish the role of CD40 (the receptor for CD40L) in neutrophil activation and inflammatory functions in vitro, and in the inflammatory and thrombotic responses to vascular injury ..
  23. Regulation of neutrophil function and inflammation by ADAM17 during infection
    Bruce K Walcheck; Fiscal Year: 2010
    ..Preliminary data in this application demonstrate that ADAM17 is regulated during neutrophil activation and apoptosis, and from a model of E...
  24. The role of Th17 cytokines in H.pylori infection
    HOLLY MARIE SCOTT ALGOOD; Fiscal Year: 2013
    ..pylori infection, and (3) determine whether IL-17 has a direct effect on neutrophil activation during H. pylori infection. In addition to enhancing our understanding of H...
  25. The Role of Syndecan-1 Shedding in Neutrophil activation in the Lung
    SAMUEL TODD NADLER; Fiscal Year: 2010
    ..The soluble complexes permit neutrophil activation. However, if the complex is not shed due to the absence of matrilysin, no activation is observed despite ..
  26. Viral Chemokine Alteration of Neutrophil Functions
    Timothy E Sparer; Fiscal Year: 2012
    ..them an integral part of the body's immune system, human cytomegalovirus (HCMV), ironically, may use neutrophil activation for its own evolutionary advantage...
  27. Imaging nanoparticle interactions with living systems
    Wynne K Schiffer; Fiscal Year: 2010
    ..perform serial PET scans, only this time we will monitor macrophage accumulation with [11C]- PK11195 or neutrophil activation with FDG at several time points up to three months after the first nano- particle scan...
  28. Neutrophil activation and trauma
    Wolfgang G Junger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neutrophil activation and trauma - Neutrophils (PMN) cause the systemic inflammatory response (SIRS) and multi-organ failure syndromes (MOFS) that damage host tissues...
  29. CINC-1 as a modulator of blood-brain barrier integrity after neonatal stroke
    Zinaida Vexler; Fiscal Year: 2010
    ..We will determine whether circulating CINC-1 protects BBB integrity (Aim 1) and limits neutrophil activation and migration (Aim 2) acutely after neonatal stroke...
  30. Neutrophil-mediated immune suppression as a mechanism of HIV-1 pathogenesis.
    Zdenek Hel; Fiscal Year: 2013
    ..we propose to define the mechanisms of neutrophil-mediated immune suppression and the mechanisms of neutrophil activation and induction of suppressor phenotype in HIV-1-infected individuals...
  31. Granule exocytosis and neutrophil activation
    Silvia M Uriarte; Fiscal Year: 2013
    The postulated role of exocytosis in mediating various functional responses associated with neutrophil activation has not been directly tested...
  32. Controlling Inflammation Due to Cardiac Devices
    REKHA BANSAL; Fiscal Year: 2012
    ..Treatment of blood with YalcioMab prior to the extracorporeal circulation prevents complement activation, neutrophil activation, monocyte activation, platelet activation and the formation of leukocyte-platelet aggregates...
  33. MYOCARDIAL OXIDANT INJURY--KESHAN DISEASE AS A MODEL
    Raymond Burk; Fiscal Year: 1992
    Oxidant stress can cause tissue damage and is implicated in the pathogenesis of some myocardial injuries. Neutrophil activation during infection, drugs, and reperfusion all cause oxidant stress and all can be associated with myocardial ..
  34. SIALIC ACID MODULATION REGULATES NEUTROPHIL DIAPEDESIS
    Alan Cross; Fiscal Year: 2002
    ..Sialidases are enzymes that rapidly remove sialic acid residues from glycoconjugates and on neutrophil activation are rapidly mobilized to plasma membrane...
  35. Regulation of CD32A in neutrophils
    Periasamy Selvaraj; Fiscal Year: 2007
    ..We hypothesize that the molecular changes that occur during neutrophil activation alter the functional state of CD32A...
  36. KALLIKREIN/KININ SYSTEM AND RHEUMATOID ARTHRITIS
    Audrey Uknis; Fiscal Year: 2000
    ..a potent vasodilator and mediator of vascular permeability and pain, and kallikrein, which causes neutrophil activation and chemotaxis...
  37. Inflammatory Mechanisms in Arterioles and Venules
    INGRID SARELIUS; Fiscal Year: 2006
    ..in situ rodent (mice, rats) skeletal muscle arterioles and venules, to define the mechanisms for neutrophil activation of permeability changes, and determine how these differ in arterioles vs. venules...
  38. ADHESION RECEPTORS AND RENAL ISCHEMIA
    K Kelley; Fiscal Year: 1999
    ..Increases in circulating cytokine levels and systemic neutrophil activation may also be responsible for myocardial dysfunction following renal ischemia and renal dysfunction in ..
  39. Radical Scavengers for Brain Ischemia Reperfusion injury
    Howard Elford; Fiscal Year: 2003
    ..injury, to lower the level of deleterious cytokines, to inhibit NF(B activation, to down regulate neutrophil activation, and most importantly to protect against cardiac reperfusion injury in three animal models...
  40. Neutrophil Specific Transgene Expression Imaging
    Daniel Schuster; Fiscal Year: 2004
    ..Even so, its exact contribution is still controversial. For instance, even the relationship of neutrophil activation to the development of lung tissue injury remains unclear...
  41. MECHANICAL CORRELATES OF NEUTROPHIL ACTIVATION
    ROBERT HOCHMUTH; Fiscal Year: 2000
    ....
  42. PATHOGENESIS OF SECONDARY BRAIN INJURY
    Steven Shackford; Fiscal Year: 1993
    ..with or without shock and resuscitation, lead to perturbations in cerebral blood flow, thrombosis, and neutrophil activation/accumulation which promote vasogenic edema, brain swelling and increased intracranial pressure...
  43. LACTOFERRIN AND MUCOSAL IMMUNITY
    Larry Thomas; Fiscal Year: 2001
    ..In addition, results suggest that neutrophil activation by chemoattractants induces a conformational change in the surface-associated lactoferrin...
  44. ROLE OF MEMBRANE PROTEASE IN NEUTROPHIL ACTIVATION
    Charles King; Fiscal Year: 1991
    ....
  45. Leukotriene B4 Receptors in Rheumatoid Arthritis
    Haribabu Bodduluri; Fiscal Year: 2006
    ..b>Neutrophil activation during host defense and inflammation is mediated by G-protein coupled receptors (GPCRs) for ..
  46. REGIONAL LUNG FUNCTION IN ACUTE LUNG INJURY
    Guido Musch; Fiscal Year: 2009
    ..4) To test whether leukotrienes mediate the process by which injurious ventilatory strategies lead to neutrophil activation and to the inflammatory cascade associated with VILI...
  47. Environmental Toxicants in Fetal Basis of Adult-onset Stroke
    VICTORIA HERRERA; Fiscal Year: 2007
    ..hypertension and hyperlipidemia, levels of cellular and circulating markers of endothelial dysfunction and neutrophil activation at pre-stroke stage (2-,3-months of age), and b...
  48. MITOCHONDRIAL FUNCTION IN OXIDATIVE INJURY
    Anna Liisa Nieminen; Fiscal Year: 1999
    ..in the pathophysiology of liver injury during xenobiotic metabolism, ischemia/reperfusion injury, and neutrophil activation. Oxidative injury occurs by a variety of mechanisms and has been studied with several diverse models ..
  49. NEUTROPHIL BACTERICIDAL ACTIVITY FOLLOWING TRAUMA
    Marc Lanser; Fiscal Year: 1992
    ..b>Neutrophil activation by PDGF is unique, since in contrast to other chemoattractants, PDGF does not itself stimulate neutrophil ..
  50. COMPLEMENT RECEPTOR EXPRESSION ON HUMAN NEUTROPHILS
    Melvin Berger; Fiscal Year: 2000
    ..This should provide valuable insights into the mechanisms underlying the sequence of events in neutrophil activation by explaining how the translocation of "readily mobilizable" compartments like the CR1 storage vesicles ..
  51. Granule exocytosis and neutrophil activation
    Silvia M Uriarte; Fiscal Year: 2010
    ..by applicant): The postulated role of exocytosis in mediating various functional responses associated with neutrophil activation has not been directly tested...
  52. Regulation of Corneal Inflammation by Fas Ligand
    Victor Perez; Fiscal Year: 2007
    ..Preliminary data demonstrate that soluble FasL is anti-inflammatory by inhibiting neutrophil activation, while membrane FasL activates them and is pro-inflammatory...
  53. MONOCLONAL ANTIBODIES--NEUTROPHIL ACTIVATION ANALYSIS
    WILLIAM NAUSEEF; Fiscal Year: 1992
    ..These studies will further understanding of the biochemical basis of PMN microbicidal action and aid in unraveling the biochemical abnormalities underlying important clinical disorders such as chronic granulomatous-disease...
  54. Metalloproteinase Control of Neutrophil Activation
    LANA HANFORD; Fiscal Year: 2006
    ..Thus, it is beneficial to tightly control neutrophil activation. The CXC chemokine KC, a functional orthologue of human IL-8, is bound to the basal epithelial cell ..
  55. MECHANISMS OF NOVEL ANTI-INFLAMMATORY ACTIONS OF SLPI
    Aihao Ding; Fiscal Year: 2007
    ..Binding of PEPI by SLPI prevents its conversion to EPIs. Both SLPI and PEPI block TNF-triggered neutrophil activation. SLPI also suppresses the macrophage response to LPS...
  56. MOLECULAR BASIS OF RECEPTOR CYCLASE COUPLING
    Henry Bourne; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  57. NEUTROPHIL ACTIVATION OF THE OXIDATIVE BURST
    Robert Clark; Fiscal Year: 1999
    ..These proposed studies will contribute to a fundamental understanding of the human neutrophil NADPH oxidase system at a molecular level and to a definition of the genetic basis for the microbicidal defect in patients with autosomal CGD. ..
  58. Regulationof Chemoattractant Activation of Neutrophils
    ALGIRDAS JESAITIS; Fiscal Year: 2007
    ..hypothesis of this proposal is that plasma membrane domains play an essential role in the regulation of neutrophil activation by providing local environments that are compositionally rich in signal transduction partners, adaptors, ..
  59. NEUTROPHIL ACTIVATION OF THE OXIDATIVE BURST
    Robert Clark; Fiscal Year: 2004
    ..non-myeloid tissues and the response to inflammatory stimuli and cell maturation. ..
  60. Heterogeneous Neutrophil Responses in Acute Lung Injury
    Charles Dinarello; Fiscal Year: 2006
    ..However, even though pathways leading to neutrophil activation are well known, their control mechanisms in the context of ALI are poorly understood...
  61. Role of Pactolus in the innate immune response
    JOHN WEIS; Fiscal Year: 2005
    ..The Pactolus protein is found in two primary configurations: truncated and membrane bound. Upon neutrophil activation, the truncated form is secreted into the supernatant...
  62. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..