neuroimmunomodulation

Summary

Summary: Influences of the nervous system (brain, spinal cord, autonomic and peripheral nervous systems) upon the immune system, principally by biochemical (i.e., neurotransmitters, receptors, etc.) and by direct neural routes. This is a two-way information transfer system.

Top Publications

  1. ncbi Neuroimmunomodulation during infectious diseases: mechanisms, causes and consequences for the host
    Oscar Bottasso
    Instituto de Inmunologia, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Rosario, Argentina
    Neuroimmunomodulation 16:65-7. 2009
  2. ncbi Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Nature 405:458-62. 2000
  3. ncbi Reflex control of immunity
    Kevin J Tracey
    Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Rev Immunol 9:418-28. 2009
  4. pmc The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
    Valentin A Pavlov
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    Mol Med 9:125-34. 2003
  5. ncbi Reproductive phenotpes of the progesterone receptor null mutant mouse
    J P Lydon
    Departement of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Steroid Biochem Mol Biol 56:67-77. 1996
  6. ncbi The emergence of neurotransmitters as immune modulators
    Rafael Franco
    Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Department of Biochemistry and Molecular Biology, Faculty of Biology, Diagonal 645, University of Barcelona, 08028 Barcelona, Spain
    Trends Immunol 28:400-7. 2007
  7. ncbi Autonomic neural regulation of immunity
    C J Czura
    North Shore LIJ Research Institute, Center for Patient Oriented Research, Manhasset, NY, USA
    J Intern Med 257:156-66. 2005
  8. ncbi Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni
    Lisa E Goehler
    Department of Psychology, University of Virginia, Charlottesville, VA 22904, United States
    Brain Behav Immun 19:334-44. 2005
  9. ncbi Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    Hong Wang
    The Center for Immunology and Inflammation, North Shore LIJ Research Institute, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Med 10:1216-21. 2004
  10. ncbi Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Auton Neurosci 85:141-7. 2000

Detail Information

Publications238 found, 100 shown here

  1. ncbi Neuroimmunomodulation during infectious diseases: mechanisms, causes and consequences for the host
    Oscar Bottasso
    Instituto de Inmunologia, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Rosario, Argentina
    Neuroimmunomodulation 16:65-7. 2009
    In this special issue of Neuroimmunomodulation, the reader will find reviewed some of the hottest topics in the field of neuroendocrine-immune interactions, with emphasis on infectious diseases...
  2. ncbi Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Nature 405:458-62. 2000
    ..Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock...
  3. ncbi Reflex control of immunity
    Kevin J Tracey
    Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Rev Immunol 9:418-28. 2009
    ..It might be possible to develop therapeutics that target neural networks for the treatment of inflammatory disorders...
  4. pmc The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
    Valentin A Pavlov
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    Mol Med 9:125-34. 2003
    ..The clinical implications of this novel mechanism also are discussed...
  5. ncbi Reproductive phenotpes of the progesterone receptor null mutant mouse
    J P Lydon
    Departement of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Steroid Biochem Mol Biol 56:67-77. 1996
    ....
  6. ncbi The emergence of neurotransmitters as immune modulators
    Rafael Franco
    Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Department of Biochemistry and Molecular Biology, Faculty of Biology, Diagonal 645, University of Barcelona, 08028 Barcelona, Spain
    Trends Immunol 28:400-7. 2007
    ..Current and future developments in understanding the cross-talk between the immune and nervous systems will probably identify new avenues for treating immune-mediated diseases using agonists or antagonists of neurotransmitter receptors...
  7. ncbi Autonomic neural regulation of immunity
    C J Czura
    North Shore LIJ Research Institute, Center for Patient Oriented Research, Manhasset, NY, USA
    J Intern Med 257:156-66. 2005
    ..The description of the cholinergic anti-inflammatory now brings to the fore several new therapeutic strategies for inflammatory disease, and suggests that many of these diseases may actually be diseases of autonomic dysfunction...
  8. ncbi Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni
    Lisa E Goehler
    Department of Psychology, University of Virginia, Charlottesville, VA 22904, United States
    Brain Behav Immun 19:334-44. 2005
    ..These findings provide evidence that peripheral sensory neurons contribute an early signal to the brain regarding potential pathogens...
  9. ncbi Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    Hong Wang
    The Center for Immunology and Inflammation, North Shore LIJ Research Institute, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Med 10:1216-21. 2004
    ....
  10. ncbi Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Auton Neurosci 85:141-7. 2000
    ..These results now identify a previously unrecognized role of efferent vagus nerve activity in mediating the central action of an anti-inflammatory agent...
  11. ncbi Targeting metabotropic glutamate receptors in neuroimmune communication
    C Volpi
    Department of Experimental Medicine and Biochemical Sciences, Section of Pharmacology, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Neuropharmacology 63:501-6. 2012
    ..In this review we primarily focus on mGluRs and their role in the crosstalk between the central nervous and immune systems during neuroinflammation...
  12. ncbi Neuroendocrine-immune interaction in fish: differential regulation of phagocyte activity by neuroendocrine factors
    B M L Verburg-van Kemenade
    Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, P O Box 338, 6700 AH, Wageningen, The Netherlands
    Gen Comp Endocrinol 172:31-8. 2011
    ..Inflammatory and microbicidal responses fight pathogens but may be detrimental to the host tissue. Neuroendocrine modulation may regulate inflammation to reach an optimum defense while preventing excessive host cell damage...
  13. ncbi Roles of muscarinic acetylcholine receptors in interleukin-2 synthesis in lymphocytes
    Y Okuma
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Jpn J Pharmacol 85:16-9. 2001
    ..Our findings demonstrate a neuro-immune interaction through muscarinic receptor signaling in immune cells...
  14. pmc Immune influence on adult neural stem cell regulation and function
    Pamela A Carpentier
    Department of Neurosurgery, 1201 Welch Road MSLS P320, Stanford University, Stanford, CA 94305, USA
    Neuron 64:79-92. 2009
    ....
  15. ncbi The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy
    J M Huston
    Department of Surgery, Division of General Surgery, Trauma, Surgical Critical Care, and Burns, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    J Intern Med 269:45-53. 2011
    ..Favourable preclinical data support the possibility that nerve stimulators may be added to the future therapeutic armamentarium, possibly replacing some drugs to inhibit cytokines...
  16. ncbi Impaired hypothalamic-pituitary-adrenal axis activity in patients with multiple sclerosis
    María C Ysrraelit
    Department of Neurology, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina
    Neurology 71:1948-54. 2008
    ..To investigate hypothalamic-pituitary-adrenal axis activity in well-defined multiple sclerosis (MS) patient subgroups...
  17. ncbi Vagus nerve stimulation in refractory epilepsy: effects on pro- and anti-inflammatory cytokines in peripheral blood
    H J M Majoie
    Epilepsy Center Kempenhaeghe, Heeze, The Netherlands
    Neuroimmunomodulation 18:52-6. 2011
    ..We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an increase of neuroprotective tryptophan metabolites...
  18. ncbi Is neuroimmunomodulation a future therapeutic approach for sepsis?
    V Kumar
    Department of Microbiology, Panjab University, Chandigarh, India
    Int Immunopharmacol 10:9-17. 2010
    ..e. cholinergic pathway activated by vagus nerve stimulation, alpha- or beta-adrenergic receptor activation etc.) in sepsis. Hence neuroimmunomodulation can be a future approach to treat sepsis.
  19. ncbi Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice
    Hidekazu Fujimaki
    National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    Neuroimmunomodulation 11:373-5. 2004
    ..The effects of low-level formaldehyde (FA) inhalation on the amount of nerve growth factor (NGF) in the hippocampus of immunized mice were studied...
  20. ncbi Depressive disorders and immunity: 20 years of progress and discovery
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California Los Angeles, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3 109, Los Angeles, CA, USA
    Brain Behav Immun 21:374-83. 2007
    ..Moreover, the work has served to instantiate brain-immune interactions as an essential component in psychiatric and medical co-morbidities and their impact on health and illness...
  21. ncbi The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis
    David J van Westerloo
    Laboratory of Experimental Internal Medicine and Department of Gastroenterology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 191:2138-48. 2005
    ..This anti-inflammatory effect is mediated by an interaction between acetylcholine, the principal neurotransmitter of the vagus nerve, and cholinergic nicotinic acetylcholine receptors on macrophages...
  22. ncbi Lateralization and catecholaminergic neuroimmunomodulation: prazosin, an alpha1/alpha2-adrenergic receptor antagonist, suppresses interleukin-1 and increases interleukin-10 production induced by lipopolysaccharides
    Jing Dong
    Neurobiologie Intégrative U394, Institut Francois Magendie, Bordeaux, France
    Neuroimmunomodulation 10:163-8. 2002
    ....
  23. ncbi Central/peripheral nervous system and immune responses
    D A Lawrence
    Wadsworth Center, Albany, NY 12201, USA
    Toxicology 142:189-201. 2000
    ..The nervous, endocrine and immune circuitry is multi-directional, and a chemical, physical or emotional stress could upset the homeostasis...
  24. ncbi Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    J Infect Dis 192:560-72. 2005
    ..These results show the dual role of the sympathetic nervous system in sepsis. It can be favorable or unfavorable, depending on the innate immune effector mechanisms necessary to overcome infection...
  25. ncbi Autonomic neuroimmunomodulation in chagasic cardiomyopathy
    Marcus Paulo Ribeiro Machado
    Department of Biological Sciences, Triangulo Mineiro Federal University, Uberaba, MG, Brazil
    Exp Physiol 97:1151-60. 2012
    ..The pathogenic implications of these potential neural immune manipulations are also discussed...
  26. ncbi Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy
    Lucy Barone
    Istituto di Cardiologia, Universita Cattolica del Sacro Cuore, Roma, Italia
    Neuroimmunomodulation 14:331-6. 2007
    ..In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy...
  27. ncbi Morphological basis of sensory neuropathy and neuroimmunomodulation in minor salivary glands of patients with Sjögren's syndrome
    B Batbayar
    Laboratory of Oral Morphology, Faculty of Dentistry, Semmelweis University, Tuzolto u 58, P O Box 95, H 1450 Budapest, Hungary
    Arch Oral Biol 49:529-38. 2004
    ..Therefore, the aim of this study was to determine the quantitative changes of the different neuropeptide containing nerve terminals and the immunocompetent cells in labial salivary glands of primary SS...
  28. ncbi Vagus-brain communication in atherosclerosis-related inflammation: a neuroimmunomodulation perspective of CAD
    Yori Gidron
    CoRPS Center of Research on Psychology in Somatic diseases, Department of Medical Psychology, Tilburg University, Tilburg, The Netherlands
    Atherosclerosis 195:e1-9. 2007
    ..Based on this converging evidence, we propose a neuroimmunomodulation approach to atherogenesis...
  29. ncbi Close apposition of dynorphin-positive nerve fibres to lymphocytes in the liver suggests opioidergic neuroimmunomodulation
    Matthias J T Kaiser
    Department of Anatomy I, University of Erlangen Nuremberg, Krankenhaustrasse 9, 91054 Erlangen, Germany
    Histochem Cell Biol 120:213-21. 2003
    ..Hence, sympathetic neurons innervating the liver may interfere with inflammatory processes, in addition to their well-established beta(2)-adrenergic effect, via an opioidergic action on immune cells...
  30. ncbi IL-1beta, TNFalpha and IL-6 induction in the rat brain after partial-body irradiation: role of vagal afferents
    C Marquette
    IRSN BP no 17 F 92262 Fontenay aux Roses cedex France
    Int J Radiat Biol 79:777-85. 2003
    ....
  31. ncbi Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy
    Nicolas P Turrin
    Laboratory of Molecular Endocrinology, Department of Anatomy and Physiology, CHUL Research Center, Laval University, Quebec, Canada G1V 4G2
    Neurobiol Dis 16:321-34. 2004
    ..These data suggest a different mechanism involved in regulating the innate immune reaction in response to seizures and could have direct implications for the neuropathology associated with epilepsy...
  32. ncbi Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary-adrenal revolving axis
    John J Haddad
    Severinghaus Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, Medical Sciences, San Francisco, CA 94143 0542, USA
    J Neuroimmunol 133:1-19. 2002
    ..In addition, we elaborate on HPA/cytokine interactions in oxidative stress within the context of nuclear factor-kappaB transcriptional regulation and the role of oxidative markers and related gaseous transmitters...
  33. ncbi Neuronal regulation of immune responses in the central nervous system
    Li Tian
    Neuroscience Center, University of Helsinki, Viikinkaari 4, FIN 00014, Helsinki, Finland
    Trends Immunol 30:91-9. 2009
    ..In addition, we specifically deal with the immune functions of neuronal cell adhesion molecules, many of which are key modulators of neuronal synaptic formation and plasticity...
  34. ncbi Physiological concentrations of dopamine inhibit the proliferation and cytotoxicity of human CD4+ and CD8+ T cells in vitro: a receptor-mediated mechanism
    B Saha
    Signal Transduction and Biogenic Amines Lab, Chittaranjan National Cancer Institute, Calcutta, India
    Neuroimmunomodulation 9:23-33. 2001
    ..CONCLUSION: Results may be of significance to understand the role of peripheral dopamine in human neuroimmune communication in terms of physiological homeostasis in health and disease...
  35. ncbi Cytokine-induced sickness behavior: mechanisms and implications
    R Dantzer
    INRA INSERM U394, Bordeaux, France
    Ann N Y Acad Sci 933:222-34. 2001
    ..However, the mechanisms that are involved in plasticity of the sickness motivational state are not yet understood...
  36. ncbi Innate and adaptive autoimmunity directed to the central nervous system
    Roopa Bhat
    Beckman Center for Molecular Medicine, B002, Stanford University, Stanford, CA 94305, USA
    Neuron 64:123-32. 2009
    ....
  37. ncbi Mechanisms of corticosteroid resistance in rheumatoid arthritis: a putative role for the corticosteroid receptor beta isoform
    Ian C Chikanza
    Bone and Joint Research Unit, John Vane Building, St Bartholomew s and Royal London School of Medicine, Charterhouse Square, London, United Kingdom
    Ann N Y Acad Sci 966:39-48. 2002
    ..It is most likely that other molecular mechanisms such as enhanced AP-1 expression are involved, and we currently are investigating such possibilities...
  38. ncbi The cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, Institute for Medical Research North Shore LIJ Health System, Manhasset, NY 11030, USA
    Brain Behav Immun 19:493-9. 2005
    ..We also discuss possible clinical implications of vagus nerve stimulation and cholinergic modalities in the treatment of inflammatory diseases...
  39. ncbi Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men
    Roland von Kanel
    Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Berne, Switzerland
    Brain Behav Immun 20:40-8. 2006
    ..The hypothalamus-pituitary-adrenal axis may attenuate stress reactivity of IL-6. The lack of habituation in IL-6 responses to daily stress could subject at-risk individuals to higher atherosclerotic morbidity and mortality...
  40. ncbi Prolactin and neuroimmunomodulation: in vitro and in vivo observations
    I C Chikanza
    Department of Rheumatology, St Bartholomews, London, United Kingdom
    Ann N Y Acad Sci 876:119-30. 1999
    ..Further study of the relationship of the PL/PLr complex, other hormones, and the immune system will provide further insights into the potential therapeutic utility of this complex in immune diseases...
  41. ncbi It takes nerve to tell T and B cells what to do
    Nicholas W Kin
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Leukoc Biol 79:1093-104. 2006
    ..We will also discuss how dysregulation of this line of communication between the nervous and immune systems might contribute to disease development and progression...
  42. ncbi Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?
    Rainer H Straub
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Germany
    J Neuroimmunol 126:116-25. 2002
    ..It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear...
  43. ncbi Neuroimmunomodulation in the pathogenesis of Alzheimer's disease
    Inelia Morales
    Laboratory of Cellular and Molecular Neurosciences LCMN, Faculty of Sciences and International Center for Biomedicine ICC, Nuñoa Santiago, Chile
    Neuroimmunomodulation 17:202-4. 2010
    ....
  44. ncbi Cytokines, stress and depressive illness: brain-immune interactions
    Hymie Anisman
    Institute of Neurosciences, Carleton University and Institute of Mental Health Research, Royal Ottawa Hospital, University of Ottawa, Canada
    Ann Med 35:2-11. 2003
    ..Furthermore, such effects are subject to a sensitization effect so that a history of stressful experiences or cytokine activation augment the response to later challenges and hence the evolution of depression..
  45. ncbi Role of neuroimmunomodulation in aging
    Monica De la Fuente
    Department of Animal Physiology, Faculty of Biology, Complutense University, Madrid, Spain
    Neuroimmunomodulation 15:213-23. 2008
    ..In the context of neuroimmunomodulation, it is now accepted that the age-related impairment of immune functions is the cause of the increased ..
  46. ncbi The mitochondrion as a primary site of action of regulatory agents involved in neuroimmunomodulation
    A M G Psarra
    Foundation for Biomedical Research of the Academy of Greece, Athens, Greece
    Ann N Y Acad Sci 1088:12-22. 2006
    A major system of neuroimmunomodulation is the hypothalamic-pituitary-adrenocortical (HPA) axis, acting through glucocorticoids and their intracellular signaling components, exerting both stimulatory and inhibitory effects on the immune ..
  47. ncbi Evidence for involvement of the neural pathway containing the peripheral vagus nerve, medullary visceral zone and central amygdaloid nucleus in neuroimmunomodulation
    X Ge
    Institute of Neurosciences, The Fourth Military Medical University, 710032, Xi'an, People's Republic of China
    Brain Res 914:149-58. 2001
    ..The MVZ is a neural relay station in the immune-to-brain communication and might play a significant role in neuroimmuno-modulation via the vagus-MVZ-Ce pathway...
  48. ncbi Neuroimmunomodulation and immune privilege: the role of neuropeptides in ocular immunosuppression
    Andrew W Taylor
    Department of Ophthalmology, Harvard Medical School, Boston, Massachussetts 02114, USA
    Neuroimmunomodulation 10:189-98. 2002
    ..With over half a century of experimental examinations of ocular immune privilege, only recently have we come to understand that neuropeptides constitutively present in ocular tissues are part of the mechanisms of immune privilege...
  49. ncbi Morphine-induced neuroimmunomodulation in murine visceral leishmaniasis: the role(s) of cytokines and nitric oxide
    Prati Pal Singh
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Phase X, S A S, Nagar 60 062, India
    J Neuroimmune Pharmacol 2:338-51. 2007
    ..These results thus demonstrate the implications of opiate abuse on the efficacy assessment of antileishmanial drugs and vaccines, and on the reactivation of latent VL in areas where both drug abuse and VL are rampant...
  50. ncbi Neuroimmunomodulation during exercise: role of catecholamines as 'stress mediator' and/or 'danger signal' for the innate immune response
    Eduardo Ortega
    Department of Physiology, Faculty of Sciences, University of Extremadura, Badajoz, Spain
    Neuroimmunomodulation 14:206-12. 2007
    Exercise-induced neuroimmunomodulation is clearly accepted today...
  51. pmc Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint)
    D Kane
    School of Clinical and Medical Sciences Rheumatology, 4th Floor, Cookson Building, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Ann Rheum Dis 64:325-7. 2005
    ..To investigate the direct effect of joint innervation on immune mediated joint inflammation in a patient with psoriatic arthritis (PsA)...
  52. ncbi Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function?
    R L Wilder
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 10, Room 9N240, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 917:784-96. 2000
    ..These initial data, however, indicate that the genetic control of the autoimmune disease traits is highly complex...
  53. ncbi Neonatal programming of neuroimmunomodulation--role of adipocytokines and neuropeptides
    E G de Moura
    Departamento de Ciencias Fisiologicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil
    Neuroimmunomodulation 15:176-88. 2008
    ....
  54. ncbi Substance P receptor mediated maintenance of chronic inflammation in EAE
    Emily K Reinke
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison WI, United States
    J Neuroimmunol 180:117-25. 2006
    ....
  55. ncbi From the brain-skin connection: the neuroendocrine-immune misalliance of stress and itch
    Petra Arck
    Center for Internal Medicine and Dermatology, Charite, University Medicine Berlin, and Department of Dermatology, University Hospital Schleswig Holstein, Lubeck, Germany
    Neuroimmunomodulation 13:347-56. 2006
    ....
  56. ncbi Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins
    M Griffiths
    Brain Inflammation and Immunity Group BIIG, Department of Medical Biochemistry, School of Medicine, Cardiff University, CF144XN Cardiff, United Kingdom
    Int Rev Neurobiol 82:29-55. 2007
    ..Moreover, NIRegs have direct beneficial effects on neurogenesis and contributing to brain tissue remodeling...
  57. ncbi Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmune encephalomyelitis
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, USA
    J Neuroimmunol 84:122-30. 1998
    ..Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE...
  58. ncbi Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions
    Lena Ohman
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, S 41345 Gothenburg, Sweden
    Nat Rev Gastroenterol Hepatol 7:163-73. 2010
    ..The link between immune alterations and severity of gastrointestinal symptoms and the positive effect of anti-inflammatory treatments in IBS further highlight the relevance of neuroimmune interactions in this condition...
  59. ncbi Complex coping patterns and their role in adaptation and neuroimmunomodulation. Theory, methodology, and research
    L R Temoshok
    Institute of Human Virology, University of Maryland, 725 West Lombard St, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 917:446-55. 2000
    ....
  60. ncbi Models of aging of neuroimmunomodulation: strategies for its improvement
    Monica De la Fuente
    Department of Physiology Animal Physiology II, Faculty of Biology, Complutense University of Madrid, Madrid, Spain
    Neuroimmunomodulation 17:213-6. 2010
    ..Therefore, they retard the aging process and seem to increase the longevity of the individuals...
  61. ncbi Neuroimmunomodulation by macrophage migration inhibitory factor (MIF)
    R Bucala
    Laboratory of Medical Biochemistry, Picower Institute for Medical Research, Manhasset, New York 10030, USA
    Ann N Y Acad Sci 840:74-82. 1998
    ....
  62. ncbi Nerve-driven immunity. The direct effects of neurotransmitters on T-cell function
    M Levite
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Ann N Y Acad Sci 917:307-21. 2000
    ..As a whole, our studies suggest an important and yet unrecognized role for neurotransmitters in directly dictating or modulating numerous T-cell functions under physiological and pathological conditions...
  63. ncbi Control of salivary secretion by nitric oxide and its role in neuroimmunomodulation
    V Rettori
    Centro de Estudios Farmacológicos y Botánicos CONICET, Serrano 669, Ciudad de Buenos Aires 1414, Argentina
    Ann N Y Acad Sci 917:258-67. 2000
    ..Therefore, the use of inhibitors of iNOS and COX-2 could be very useful to increase salivation during infection since saliva has antimicrobial actions...
  64. pmc Immune-neuroendocrine interactions and autoimmune diseases
    Luis J Jara
    Research Division, Clinical and Epidemiology Research Unit, Internal Medicine Department, Hospital de Especialidades Contro Médico La Raza, IMSS, Mexico City, Mexico
    Clin Dev Immunol 13:109-23. 2006
    ..The interactions between the immune-neuroendocrine system have a major impact on our understanding of the pathogenic mechanisms, diagnosis and therapy of ARD...
  65. ncbi Central catecholamine depletion inhibits peripheral lymphocyte responsiveness in spleen and blood
    Gustavo Pacheco-López
    Department of Medical Psychology, University of Duisburg Essen, Essen, Germany
    J Neurochem 86:1024-31. 2003
    ..These data demonstrate a crucial role of central and peripheral catecholamines in modulating immune function...
  66. ncbi In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids
    Michelle Roche
    Department of Physiology, National University of Ireland, Galway, University Road, Galway, Ireland
    J Neuroimmunol 181:57-67. 2006
    ..These data provide evidence for modulation of pro-inflammatory cytokines in vivo by cannabinoid receptors and inform the development of cannabinoids for neuroinflammatory disorders...
  67. ncbi Stress-induced suppression of in vivo splenic cytokine production in the rat by neural and hormonal mechanisms
    Jonathan C Meltzer
    National Research Council of Canada Institute for Biodiagnostics, Winnipeg, MB, Canada R3E 0W3
    Brain Behav Immun 18:262-73. 2004
    ..Adrenal demedullation of animals with a SNC demonstrated that the SNS, not the HPAA, was primarily responsible for the immunosuppressive effects of stress...
  68. ncbi Physical training attenuates the stress-induced changes in rat T-lymphocyte function
    Carol Góis Leandro
    Superior School of Physical Education, Federal University of Pernambuco, Recife, Brazil
    Neuroimmunomodulation 13:105-13. 2006
    ..Moderate physical training is associated with beneficial effects on immunological functions. We investigated the effects of a moderate physical training on T-lymphocyte function in rats submitted to acute restraint stress...
  69. pmc Neural immune pathways and their connection to inflammatory diseases
    Farideh Eskandari
    Section on Neuroendocrine Immunology and Behavior, NIMH NIH, Bethesda, MD, USA
    Arthritis Res Ther 5:251-65. 2003
    ..This review discusses neuroimmune interactions and evidence for the role of such neural immune regulation of inflammation, rather than a discussion of the individual inflammatory mediators, in rheumatoid arthritis...
  70. pmc Neuroendocrine-immune interactions in rheumatoid arthritis: mechanisms of glucocorticoid resistance
    Marni N Silverman
    Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Rockville, MD 20852, USA
    Neuroimmunomodulation 15:19-28. 2008
    ..Therefore, further elucidation of these mechanisms will reveal new targets for therapeutic intervention in the treatment of RA...
  71. ncbi Consequences of repeated early isolation in domestic piglets (Sus scrofa) on their behavioural, neuroendocrine, and immunological responses
    Ellen Kanitz
    Research Unit Behavioural Physiology, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Brain Behav Immun 18:35-45. 2004
    ..Using the pig as a suitable animal model, the finding of this study may also have some implications for the etiology of anxiety and depression in humans...
  72. ncbi Neuroendocrine and cytokines-induced responses to minutes, hours, and days of mental stress
    Khalid Z Matalka
    Faculty of Pharmacy and Medical Technology, University of Petra, Amman, Jordan
    Neuro Endocrinol Lett 24:283-92. 2003
    ..g. brief and written examination stress as subacute and acute type of stressor) that have been utilized to understand the effect of stress on the neuroendocrine and immune systems...
  73. ncbi CCK mRNA expression in neuroendocrine CRH neurons is increased in rats subjected to an immune challenge
    C Juaneda
    Laboratoire de Neurocytochimie Fonctionnelle, , EA 2972, , 33405 Cedex, Talence, France
    Brain Res 901:277-80. 2001
    ..Compared to controls, LPS-injected rats displayed increased (185%) parvicellular CCK mRNA expression levels, occurring in a majority (70%) of CRH neurons as revealed by dual-label ISHH...
  74. ncbi Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents
    R Yirmiya
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, Israel
    Neuropsychopharmacology 24:531-44. 2001
    ..The effects of antidepressants on the acute phase response may have important clinical implications for the psychiatric and neuroendocrine disturbances that are commonly associated with various medical conditions...
  75. ncbi [New data about neuroimmunomodulation and its functional implications]
    I Haulica
    Facultatea de Medicina, Disciplina de Fiziologie, Universitatea de Medicină si Farmacie Gr T Popa Iaşi
    Rev Med Chir Soc Med Nat Iasi 107:699-709. 2003
    ..To close, the psychoemotional components of the neuroimmunomodulator circuits are mentioned, using as examples the changes induced by stress generally and oxidative stress in particular...
  76. ncbi Psychoneuroimmunology and related mechanisms in understanding health disparities in vulnerable populations
    Teresita L Briones
    University of Illinois at Chicago, USA
    Annu Rev Nurs Res 25:219-56. 2007
    ..Given that the relevant literature on these topics is vast, the presentation in this chapter will serve to highlight primary references that reflect state of the science in these systems of focus...
  77. ncbi Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects
    John J Haddad
    Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon
    Biochem Biophys Res Commun 323:361-71. 2004
    ....
  78. ncbi Activation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system during inflammation and altered programming of the neuroendocrine-immune axis during fetal and neonatal development: lessons learned from the model inflammagen, lipopolysac
    N A Karrow
    Centre for the Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Ont, Canada, N1G 2W1
    Brain Behav Immun 20:144-58. 2006
    ....
  79. ncbi Cytokine mRNA levels in brain and peripheral tissues of the rat: relationships with plus-maze behavior
    Cornelius R Pawlak
    Experimental and Physiological Psychology, Philipps University of Marburg, Gutenbergstr 18, 35032 Marburg, Germany
    Brain Res Mol Brain Res 137:159-65. 2005
    ..These results provide new evidence indicating that cytokine mRNA in the brain can be related to elevated plus-maze behavior and that this relationship is site (prefrontal cortex, striatum)- and cytokine mRNA-specific (IL-2)...
  80. ncbi Bottom-up and top-down signaling of IL-6 with and without habituation?
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany
    Brain Behav Immun 20:37-9. 2006
  81. ncbi Effects of combined stress during intense training on cellular immunity, hormones and respiratory infections
    Danielle Gomez-Merino
    Department of Physiology, IMASSA, Bretigny sur Orge, France
    Neuroimmunomodulation 12:164-72. 2005
    ....
  82. ncbi Effects of carrageenan and morphine on acute inflammation and pain in Lewis and Fischer rats
    Karamarie Fecho
    Department of Anesthesiology, Division of Pain Medicine, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Behav Immun 21:68-78. 2007
    ..These results suggest a positive relationship between HPA axis activity and acute inflammation and inflammatory pain. In contrast, little evidence is provided for HPA axis involvement in morphine's anti-inflammatory or analgesic effects...
  83. ncbi A temporal framework for understanding the effects of stressful life events on inflammation in patients with multiple sclerosis
    David C Mohr
    Department of Psychiatry and Neurology, University of California, San Francisco, CA 94131, USA
    Brain Behav Immun 20:27-36. 2006
    ..These three hypotheses are not necessarily mutually exclusive. Data on psychosocial mediators and moderators are also briefly reviewed and future research directions are discussed...
  84. ncbi Early life host-bacteria relations and development: long-term individual differences in neuroimmune function following neonatal endotoxin challenge
    Frederick R Walker
    Laboratory of Neuroimmunology, School of the Behavioural Sciences, University of Newcastle, 2308 NSW, Australia
    Physiol Behav 87:126-34. 2006
    ..Collectively, these findings demonstrate that neonatal endotoxin challenge does not affect a blanket down regulation of inflammatory processes but rather appears to induce highly specific alterations in the adult male Fischer-344 rat...
  85. ncbi The effect of pain on leukocyte cellular adhesion molecules
    Charles A Griffis
    Department of Anesthesiology, School of Nursing, University of California, Los Angeles 90095, USA
    Biol Res Nurs 7:297-312. 2006
    ..Clinical implications and suggestions for further research in the area of painful stress-related inflammation are offered...
  86. ncbi Actual data concerning the brain--immune system interface
    I Haulica
    Gr T Popa University of Medicine and Pharmacy, Department of Physiology, Iasi, Romania
    Roum Arch Microbiol Immunol 61:141-57. 2002
    ..To close, the psychoemotional components of the neuro-immunomodulator circuits will be mentioned, using as examples the changes induced by stress generally and oxidative stress in particular...
  87. ncbi Acute diclofenac treatment attenuates lipopolysaccharide-induced alterations to basic reward behavior and HPA axis activation in rats
    Richard De La Garza
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Forchheimer Building, Room 111, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Psychopharmacology (Berl) 179:356-65. 2005
    ....
  88. ncbi Stress-induced changes in LPS-induced pro-inflammatory cytokine production in chronic fatigue syndrome
    Jens Gaab
    Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany
    Psychoneuroendocrinology 30:188-98. 2005
    ....
  89. ncbi Neural substrates, experimental evidences and functional hypothesis of acupuncture mechanisms
    Z H Cho
    Department of Radiological Sciences, University of California, Irvine, CA 92697, USA
    Acta Neurol Scand 113:370-7. 2006
    ..We, therefore, have studied acupuncture analgesic effect through fMRI and proposed a hypothesis, based on the obtained result, which will enlighten the central role of the brain in acupuncture therapy...
  90. ncbi Bidirectional communication between the brain and the immune system: implications for physiological sleep and disorders with disrupted sleep
    Dianne Lorton
    Hoover Arthritis Research Center, Sun Health Research Institute, Sun City, AZ 85372, USA
    Neuroimmunomodulation 13:357-74. 2006
    ..This article reviews our current understanding of neuroimmune interactions in normal sleep and sleep deprivation, and the influence of these interactions on selected disorders characterized by pathological sleep...
  91. ncbi The emerging role of peripheral corticotropin-releasing hormone (CRH)
    I Ilias
    Endocrine Unit, Medical School, University of Athens, Evgenidion Hospital and 2nd Department of Endocrinology, Alexandra Hospital, Athens, Greece
    J Endocrinol Invest 26:364-71. 2003
    ..Additonally, antalarmin has been shown to reduce the inflammatory-like reaction of the endometrium to the invading blastocyst, with a possible therapeutic potential as a non-steroidal inhibitor of pregnancy at its early stages...
  92. ncbi The effects of corticosterone and beta-endorphin on adherence, phagocytosis and hydrogen peroxide production of macrophages isolated from Dark Agouti rats exposed to acute stress
    Stanislava Stanojevic
    Institute of Virology, Vaccines and Sera Torlak, Immunology Research Center Branislav Jankovic, Belgrade, Serbia
    Neuroimmunomodulation 15:108-16. 2008
    ....
  93. ncbi Endocrine and cytokine responses to acute psychological stress in multiple sclerosis
    Christoph Heesen
    Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Brain Behav Immun 16:282-7. 2002
    ..An altered neural immune signaling in relapsing-remitting MS patients during acute experimental stress could not be proven for the parameters analyzed...
  94. ncbi Maternal deprivation of rat pups increases clinical symptoms of experimental autoimmune encephalomyelitis at adult age
    Marc A T Teunis
    Laboratory for Psychoneuroimmunology, Department of Immunology, Wilhelmina Children s Hospital of the University Medical Center Utrecht, Utrecht, The Netherlands
    J Neuroimmunol 133:30-8. 2002
    ..We conclude that short-lasting neonatal maternal deprivation of rat pups has long-lasting consequences for macrophage activity and for susceptibility to the inflammatory autoimmune disease EAE...
  95. ncbi Neuroimmunoendocrinology of the rheumatic diseases: past, present, and future
    Ronald L Wilder
    Department of Clinical Development, MedImmune, Inc, Gaithersburg, Maryland 20878, USA
    Ann N Y Acad Sci 966:13-9. 2002
    ..Moreover, it is highly likely that improved understanding of these interactions will translate into improved therapy for the rheumatic diseases...
  96. ncbi Central nervous system recognition of peripheral inflammation: a neural, hormonal collaboration
    Stephen J Hopkins
    Injury Research Group, Clinical Sciences Building, Hope Hospital, Salford, Greater Manchester, M6 8HD UK
    Acta Biomed 78:231-47. 2007
    ....
  97. ncbi Neuroendocrine-immune (NEI) circuitry from neuron-glial interactions to function: Focus on gender and HPA-HPG interactions on early programming of the NEI system
    M C Morale
    Department of Pharmacology, Medical School, University of Sassari, Sassari, Italy
    Immunol Cell Biol 79:400-17. 2001
    ..The overall study highlights the plasticity of this intersystem cross-talk for pharmacological targeting with drugs acting at the neuroendocrine-immune interface...
  98. ncbi Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation
    Vera Chesnokova
    Cedars Sinai Research Institute University of California Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Am J Physiol Endocrinol Metab 282:E1110-8. 2002
    ..05). The results indicate that, although LIF induces ACTH, SOCS-3 acts to counterregulate the HPA axis response to inflammation...
  99. ncbi Effects of hippocampal lesioning on experimental periodontitis in Wistar rats
    T Breivik
    Department of Periodontology, Faculty of Dentistry, University of Oslo, Norway
    J Periodontal Res 37:360-5. 2002
    ..This finding supports recent studies that indicate that inappropriate brain-neuroendocrine regulation of inflammatory responses to infectious agents may play an important role in disease susceptibility and progression...
  100. ncbi Does the pineal gland have a role in the psychological mechanisms involved in the progression of cancer?
    B D Callaghan
    Department of Anatomical Sciences, University of Adelaide, Adelaide, Australia
    Med Hypotheses 59:302-11. 2002
    ..It is thus hypothesized that the pineal gland, and melatonin, are involved in the mechanism of psychological effects in the promotion of the progress of cancer...
  101. ncbi Post-traumatic stress disorder: advances in psychoneuroimmunology
    Cheryl M Wong
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx VAMC, OOMH 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychiatr Clin North Am 25:369-83, vii. 2002
    ....

Research Grants63

  1. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..This may advance the understanding of mind-body interaction and lead to the development of new strategies of interventions to improve the treatment of mental disorders in chronically ill patients. ..
  2. Spinal Neuroimmune Mechanisms Underlying IL-10 Gene Therapy for Pain Control
    Erin D Milligan; Fiscal Year: 2013
    ....
  3. Cross-sensitization in the pelvis and neurogenic bladder
    Anna P Malykhina; Fiscal Year: 2012
    ..Uncovering of these mechanisms will lead to the development of new therapeutic protocols that can be used to alleviate the chronic pelvic pain in patients with genitourinary and gastrointestinal disorders. ..
  4. Scavenger Receptors Type-A of Microglia Promote Abeta Uptake After Abeta Immunot
    Donald L Price; Fiscal Year: 2012
    ..This application addresses issues directly relevant to the development of immunotherapy or a vaccine for Alzheimer's. ..
  5. Neuroimmune Mechanisms of Glucocorticoid Resistance
    Andrew H Miller; Fiscal Year: 2010
    ..Taken together, these studies will help identify novel targets for the treatment of mood disorders in both medically ill and medically healthy patients. ..
  6. 11th International Congress of Neuroimmunology
    Samia J Khoury; Fiscal Year: 2012
    ..basic immunology and neurobiology, through neurochemistry, pharmacology, endocrinology, neuropathology and neuroimmunomodulation, to clinical immunology and neurology...
  7. Patient-Partner Stress Management Effects on CFS Symptoms and Neuroimmune Process
    MICHAEL HOWARD ANTONI; Fiscal Year: 2013
    ..T-HI, n=75) as the between-group factor, and time (Pre-intervention, 5- and 9- month follow-up) as the within-group factor. ..
  8. Neuroimmune Mechanisms of Risk and Resilience to Maladaptive Responses to Stress
    Leonardo H Tonelli; Fiscal Year: 2013
    ..These studies will provide insight into cellular mechanisms of resilience to psychogenic stress that when stimulated may provide regenerative and repair functions in the brain and restore normal stress responses and behaviors. ..
  9. NEUROIMMUNOMODULATION IN HUMAN GUT MUCOSA
    Peter Anton; Fiscal Year: 1993
    b>Neuroimmunomodulation of the mucosal immune system is though to exist, but has not been demonstrated. Evidence to support this hypothesis is based on animal studies of systemic and non-mucosal immunocytes...
  10. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 1999
    ....
  11. NEUROIMMUNE MECHANISMS OF MORPHINE IMMUNOSUPPRESSION
    JOHN ROSECRANS; Fiscal Year: 1993
    ..Completion of the proposed experiments should contribute to an understanding of the direct and neuroimmune mechanisms through which morphine is able to suppress immunity...
  12. VIII International Congress of Neuroimmunology
    CEDRIC RAINE; Fiscal Year: 2006
    ..basic immunology and neurobiology, through neurochemistry, pharmacology, endocrinology, neuropathology and neuroimmunomodulation, to clinical immunology and neurology...
  13. Cognitive Behavioral Stress Management for Chronic Fatigue Syndrome
    Michael Antoni; Fiscal Year: 2009
    ....
  14. NEUROIMMUNE MECHANISMS OF VISCERAL HYPERALGESIA
    Michael Pezzone; Fiscal Year: 2003
    ..abstract_text> ..
  15. 7th International Congress of Neuroimmunology
    CEDRIC RAINE; Fiscal Year: 2004
    ..basic immunology and neurobiology, through neurochemistry, pharmacology, endocrinology, neuropathology and neuroimmunomodulation, to clinical immunology and neurology...
  16. Neuroimmune Mechanisms of Visceral Pain
    Michael Pezzone; Fiscal Year: 2005
    ..The aims of this project will be addressing several highly clinically relevant areas involving colonic sensory and motor function and will utilize physiological, electrophysiological, and molecular techniques. ..
  17. Stress Effects on an Animal Model of Autoimmune Disease
    CHRISTABEL WELSH; Fiscal Year: 2005
    ..Clarifying how environmental stressors influence an individual's vulnerability to autoimmune disease may increase our understanding of diseases such as multiple sclerosis and thus lead to the development of therapeutic regimens. ..
  18. Perinatal Infection and Memory
    STACI BILBO; Fiscal Year: 2006
    ..The duration of memory impairment will also be measured, and a number of memory paradigms will be tested. ..
  19. Therapeutics for Chronic Lung Diseases: Antagonists of PGP, Chemokines and CXCR
    J Edwin Blalock; Fiscal Year: 2010
    ..In addition, we will evaluate PGP as a novel biomarker for COPD as well as a prognosticator of potential utility of (D-P)G(D-P) as a therapeutic agent. ..
  20. Chronic Alcohol & AIDS Impact on Muscle Wasting
    Patricia Molina; Fiscal Year: 2006
    ..abstract_text> ..
  21. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  22. Neurocircuitry of Illness Induced Behavioral Depression
    LISA GOEHLER; Fiscal Year: 2009
    ....
  23. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010
    ....
  24. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Edwin Blalock; Fiscal Year: 2010
    ..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. (End of Abstract) ..
  25. Cannabinoid effects on HIV/AIDS
    Patricia E Molina; Fiscal Year: 2010
    ....
  26. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  27. IMMUNOTHERAPY OF MYASTHENIA GRAVIS
    J Blalock; Fiscal Year: 2001
    ..Is there restricted usage of TCR by AChR 100-116 specific T-cells recognized by CTCR8? 6. Can EAMG-associated T-cells of other specificities be identified with complementary peptides to different AChR T-cell epitopes? ..
  28. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  29. Alcoholism and Disease: Immune /Pathological Mechanisms
    Patricia Molina; Fiscal Year: 2002
    ..the auspices of the American Association of Investigative Pathologists and the International Society for Neuroimmunomodulation (respectively)...
  30. Neural and Immune Cell Interactions: Two of a Kind
    LISA GOEHLER; Fiscal Year: 2002
    ..Finally, the interactions between immune and neural cells may well be bi-directional, providing a novel mechanism by which neural activity can modulate immune cell functions. ..
  31. Epithelial Ca2+ Channels:Therapeutic Targets in Asthma
    J Blalock; Fiscal Year: 2005
    ..Can the level of NO production be modulated by agents that open or close AEC SOC? 5. Which form of NOS is involved in regulation of airway responsiveness by agents that modify AEC SOC? ..
  32. STRESSOR CONTROLLABILITY, DRUGS OF ABUSE, AND SEROTONIN
    Steven F Maier; Fiscal Year: 2010
    ....
  33. SCIENCE PARTNERSHIPS FOR HANDS-ON LEARNING -PHASE II
    Jan Moynihan; Fiscal Year: 2003
    ..Teachers will have use of a "lending library" of science equipment and supplies to perform activities in their classrooms. ..
  34. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
  35. Microglial Regulation in Opioid Tolerance, Hyperalgesia and Addiction
    JOYCE DELEO; Fiscal Year: 2009
    ..These studies may also aid in elucidating substance abuse-induced plasticity, the physiological correlate to craving and relapse in drug addiction. ..
  36. DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLY
    Michael Irwin; Fiscal Year: 2003
    ....
  37. GENERAL CLINICAL RESEARCH CENTER
    Kevin J Tracey; Fiscal Year: 2010
    ..This proposal seeks continued funding for the Feinstein GCRC by NCRR. ..
  38. Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms
    Michael R Irwin; Fiscal Year: 2010
    ..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
  39. EFECTS OF STRESS IN IMMUNOCOMPROMISED HOSTS
    Jan Moynihan; Fiscal Year: 2003
    ..In turn, this will result in prolonged allograft survival. In contrast, the immunocompromised animal will have poorer immune responses to an opportunistic pathogen (HSV-1). ..
  40. The Rochester Center for Mind-Body Research
    Jan Moynihan; Fiscal Year: 2006
    ..By the end of the award period, we will be a mature, established Center with a submitted program project or Center grant application. ..
  41. MECHANISM OF CIGARETTE SMOKE-INDUCED IMMUNOSUPPRESSION
    Mohan Sopori; Fiscal Year: 2003
    ..Additionally, the results may provide insight into the mechanism of T cell tolerance and neuroimmune interactions. ..
  42. BEHAVIORAL INTERVENTION FOR HERPES ZOSTER RISK IN AGING
    Michael Irwin; Fiscal Year: 2003
    ....
  43. Immunoregulation by Endogenous Opioids
    Jan Moynihan; Fiscal Year: 2004
    ..Specific Aim 4: To determine if C57B1/6 mice, which do not have altered immune responses to KLH following stress odor exposure, have evidence of elevated endogenous opioids following odor exposure. ..
  44. Sleep and Immune Mechanisms in Rheumatoid Arthritis
    Michael Irwin; Fiscal Year: 2009
    ..Results from this study will guide the development of interventions that target disordered sleep with potential effects on disability in RA. ..
  45. ROLE OF CONDITIONING IN THE PHARMACOTHERAPY OF PSORIASIS
    Robert Ader; Fiscal Year: 2004
    ....
  46. CYTOKINE AND HORMONE INTERACTIONS IN COMORBIDITY OF AIDS
    Keith Kelley; Fiscal Year: 2005
    ..abstract_text> ..
  47. RESEARCH PERSPECTIVES IN PNI, TRAINEE TRAVEL
    Michael Irwin; Fiscal Year: 2006
    ..abstract_text> ..
  48. Cocaine Dependence: EEG Sleep and Cytokines
    Michael Irwin; Fiscal Year: 2005
    ..abstract_text> ..
  49. Physical Activity, Aging and Immune Function
    Jeffrey Woods; Fiscal Year: 2005
    ..In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function. ..
  50. Alcoholism: Sleep and Cytokines in African Americans
    Michael Irwin; Fiscal Year: 2005
    ..g., cytokine antagonists) for sleep disturbance in alcoholism. ..
  51. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
    ....
  52. Nicotine & Immunopathogenesis of Cryptococcal meningitis
    Mohan Sopori; Fiscal Year: 2007
    ..abstract_text> ..
  53. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
    ....
  54. MACROPHAGE HETEROGENEITY AFTER SPINAL CORD INJURY
    Phillip Popovich; Fiscal Year: 2008
    ..In this way, CNS macrophages could be used as vehicles for drug delivery. [unreadable] [unreadable]..
  55. CYTOKINES, BEHAVIOR, AND MENTAL HEALTH
    Keith Kelley; Fiscal Year: 2008
    ..These innovative experiments will advance our understanding of brain and immune communication systems that control the neurobiological basis of behavioral disorders ..
  56. Mindfulness to Improve Elders' Immune and Health Status
    Jan Moynihan; Fiscal Year: 2008
    ..The findings of this RCT will have implications for the conceptualization, refinement, and dissemination of psychosocial interventions aimed at slowing the rate of immunosenescence. ..
  57. Corticotropin Releasing Factor-Norepinephrine Interactions in Stress & Depression
    ADRIAN DUNN; Fiscal Year: 2008
    ..The results should establish a model and indicate the nature of the cerebral structures involved, so that we can subsequently test the feed-forward hypothesis [unreadable] [unreadable]..
  58. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  59. Sympathetic Modulation of the Immune System in Aging
    Denise Bellinger; Fiscal Year: 2005
    ..Specific Aim 3 explores possible mechanisms responsible for the age-related differences in sympathetic innervation of secondary lymphoid organs from these two rat strains. ..
  60. Functional Relevance of Microglial Cannabinoid Receptors
    Guy Cabral; Fiscal Year: 2004
    ..Functional assays will employ paired cannabinoid enantiomers, receptor subtype-specific antagonists, and cannabinoids exhibiting differential ligand binding affinities to establish structure-activity relationships. ..
  61. Mechanisms of Psychosocial Influences on Prostate Cancer
    Denise Bellinger; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..