blood bactericidal activity

Summary

Summary: The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.

Top Publications

  1. pmc The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance
    Guillermo Madico
    Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 177:501-10. 2006
  2. ncbi Meningococcal surrogates of protection--serum bactericidal antibody activity
    Ray Borrow
    Meningococcal Reference Unit, Health Protection Agency North West Laboratory, Manchester Royal Infirmary, Manchester M13 9WZ, UK
    Vaccine 23:2222-7. 2005
  3. ncbi Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005
    R Borrow
    Vaccine Evaluation Unit, Health Protection Agency, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom
    Vaccine 24:5093-107. 2006
  4. ncbi Bactericidal antibody is the immunologic surrogate of protection against meningococcal disease
    Carl E Frasch
    Frasch Biologics Consulting, PO Box 986, Martinsburg, WV, USA 25402
    Vaccine 27:B112-6. 2009
  5. pmc A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination
    Peter T Beernink
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Immunol 186:3606-14. 2011
  6. ncbi Sialic acid-containing lipopolysaccharides of Salmonella O48 strains--potential role in camouflage and susceptibility to the bactericidal effect of normal human serum
    Gabriela Bugla-Płoskońska
    Department of Microbiology, Institute of Genetics and Microbiology, University of Wrocław, Przybyszewskiego 63 77, 51 148 Wrocław, Poland
    Microb Ecol 59:601-13. 2010
  7. pmc The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial
    Helena M Linge
    Divisions of Infection, Department of Clinical Sciences Lund, Lund University, SE 221 84 Lund, Sweden
    Antimicrob Agents Chemother 52:2599-607. 2008
  8. pmc Inadequate binding of immune regulator factor H is associated with sensitivity of Borrelia lusitaniae to human complement
    Roswitha Dieterich
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Frankfurt, Germany
    Infect Immun 78:4467-76. 2010
  9. ncbi Regulation of complement activation at the C3-level by serum resistant leptospires
    Taru Meri
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, P O Box 21, 00014 Helsinki, Finland
    Microb Pathog 39:139-47. 2005
  10. pmc Role of lgtC in resistance of nontypeable Haemophilus influenzae strain R2866 to human serum
    Alice L Erwin
    Microbial Pathogens Program, Seattle Biomedical Research Institute, 307 Westlake Ave North, Suite 500, Seattle, WA 98109 5219, USA
    Infect Immun 74:6226-35. 2006

Research Grants

Detail Information

Publications184 found, 100 shown here

  1. pmc The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance
    Guillermo Madico
    Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 177:501-10. 2006
    ..These data provide further support for inclusion of this molecule in a meningococcal vaccine. To reflect the critical function of this molecule, we suggest calling it fH-binding protein...
  2. ncbi Meningococcal surrogates of protection--serum bactericidal antibody activity
    Ray Borrow
    Meningococcal Reference Unit, Health Protection Agency North West Laboratory, Manchester Royal Infirmary, Manchester M13 9WZ, UK
    Vaccine 23:2222-7. 2005
    ..SBA activity as a correlate of protection for evaluating the immune response to meningococcal vaccines is described in this review...
  3. ncbi Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005
    R Borrow
    Vaccine Evaluation Unit, Health Protection Agency, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom
    Vaccine 24:5093-107. 2006
  4. ncbi Bactericidal antibody is the immunologic surrogate of protection against meningococcal disease
    Carl E Frasch
    Frasch Biologics Consulting, PO Box 986, Martinsburg, WV, USA 25402
    Vaccine 27:B112-6. 2009
    ..3) Meningococcal polysaccharide, polysaccharide-protein conjugates, and outer membrane vesicle vaccines all induce SBA shown to be effective in direct proportion to the percent of vaccinees with SBA activity...
  5. pmc A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination
    Peter T Beernink
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Immunol 186:3606-14. 2011
    ....
  6. ncbi Sialic acid-containing lipopolysaccharides of Salmonella O48 strains--potential role in camouflage and susceptibility to the bactericidal effect of normal human serum
    Gabriela Bugla-Płoskońska
    Department of Microbiology, Institute of Genetics and Microbiology, University of Wrocław, Przybyszewskiego 63 77, 51 148 Wrocław, Poland
    Microb Ecol 59:601-13. 2010
    ..As the pathogenicity of most Salmonella serotypes remains undefined, research into the interactions between these bacterial cells and host organisms is indispensable...
  7. pmc The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial
    Helena M Linge
    Divisions of Infection, Department of Clinical Sciences Lund, Lund University, SE 221 84 Lund, Sweden
    Antimicrob Agents Chemother 52:2599-607. 2008
    ..Taken together, GCP/CXCL6, in addition to its chemotactic and angiogenic properties, is likely to contribute to direct antibacterial activity during localized infection...
  8. pmc Inadequate binding of immune regulator factor H is associated with sensitivity of Borrelia lusitaniae to human complement
    Roswitha Dieterich
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Frankfurt, Germany
    Infect Immun 78:4467-76. 2010
    ..This finding suggests that a reduced binding capability of CFH is associated with an increased serum sensitivity of B. lusitaniae to human complement...
  9. ncbi Regulation of complement activation at the C3-level by serum resistant leptospires
    Taru Meri
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, P O Box 21, 00014 Helsinki, Finland
    Microb Pathog 39:139-47. 2005
    ..Thus, binding of this major alternative complement pathway inhibitor is related to serum resistance in Leptospira spirochetes...
  10. pmc Role of lgtC in resistance of nontypeable Haemophilus influenzae strain R2866 to human serum
    Alice L Erwin
    Microbial Pathogens Program, Seattle Biomedical Research Institute, 307 Westlake Ave North, Suite 500, Seattle, WA 98109 5219, USA
    Infect Immun 74:6226-35. 2006
    ..This is the first description of the genetic basis of high-level serum resistance in NTHI, as well as the first description of LOS composition in an NTHI strain for which the complete genome sequence has been determined...
  11. ncbi Capture stress and the bactericidal competence of blood and plasma in five species of tropical birds
    Kevin D Matson
    Department of Biology, University of Missouri, St Louis, 63121, USA
    Physiol Biochem Zool 79:556-64. 2006
    ..One hour of acute stress reduced killing ability by up to 40%. This assay is expected to be useful in evolutionary and ecological studies dealing with physiological and immunological differences in birds...
  12. ncbi Immunogenicity of a single dose of tetravalent meningococcal serogroups A, C, W-135, and Y conjugate vaccine administered to 2- to 10-year-olds is noninferior to a licensed-ACWY polysaccharide vaccine with an acceptable safety profile
    Ziad A Memish
    National Guard Affairs, King Abdulaziz Medical City, Riyadh, Saudi Arabia
    Pediatr Infect Dis J 30:e56-62. 2011
    ....
  13. pmc Measurement of functional anti-meningococcal serogroup a activity using strain 3125 as the target strain for serum bactericidal assay
    Jan T Poolman
    GlaxoSmithKline Biologicals, Rixensart 1330, Belgium
    Clin Vaccine Immunol 18:1108-17. 2011
    ..In conclusion, SBA results obtained using the MenA L10 3125 strain better reflected vaccine-induced immunity...
  14. ncbi Whole blood bactericidal activity during treatment of pulmonary tuberculosis
    Robert S Wallis
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Infect Dis 187:270-8. 2003
    ..bactericidal activity against intracellular Mycobacterium tuberculosis in whole blood culture (whole blood bactericidal activity; WBA) during TB treatment...
  15. pmc Immunogenicity of a meningococcal native outer membrane vesicle vaccine with attenuated endotoxin and over-expressed factor H binding protein in infant rhesus monkeys
    Oliver Koeberling
    Novartis Vaccines, Siena, Italy
    Vaccine 29:4728-34. 2011
    ..Thus, the mutant NOMV vaccine elicited broadly protective serum antibodies in a non-human infant primate model that is more relevant for predicting human antibody responses than mice...
  16. pmc CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi
    Melisha R Kenedy
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Infect Immun 77:2773-82. 2009
    ..The combined data lead us to conclude that the CspA-mediated binding of human FH confers serum resistance by directly inhibiting complement deposition on the surface of B. burgdorferi...
  17. pmc Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activity
    Joyce S Plested
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Clin Vaccine Immunol 16:785-91. 2009
    ....
  18. ncbi The mechanisms of activation of normal human serum complement by Escherichia coli strains with K1 surface antigen
    G Bugla-Płoskońska
    Institute of Genetics and Microbiology University of Wroclaw, Poland
    Folia Microbiol (Praha) 51:627-32. 2006
    ..Important role of alternative pathway activation in the bactericidal action of NHS against E. coli K1 strains independent of the classical and lectin pathways was not established...
  19. pmc Sialylation of Neisseria meningitidis lipooligosaccharide inhibits serum bactericidal activity by masking lacto-N-neotetraose
    M M Estabrook
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Infect Immun 65:4436-44. 1997
    ..Both endogenous and exogenous lipooligosaccharide sialylation are associated with increased serum resistance by masking LNnT...
  20. pmc Incidence of Klebsiella species in surface waters and their expression of virulence factors
    R Podschun
    Department of Medical Microbiology and Virology, University of Kiel, Kiel, Germany
    Appl Environ Microbiol 67:3325-7. 2001
    ..pneumoniae, unlike those of K. oxytoca and K. planticola, are as capable as clinical isolates of expressing putative virulence factors such as serum resistance and capsular polysaccharides, pili, and siderophores...
  21. ncbi Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity
    Jo Anne Welsch
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Infect Dis 188:1730-40. 2003
    ..GNA2132 is thus a promising vaccine candidate for prevention of disease caused by N. meningitidis...
  22. pmc Cpa, the outer membrane protease of Cronobacter sakazakii, activates plasminogen and mediates resistance to serum bactericidal activity
    A A Franco
    Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Laurel, Maryland, USA
    Infect Immun 79:1578-87. 2011
    ..These results strongly suggest that Cpa may be an important virulence factor involved in serum resistance, as well as in the spread and invasion of C. sakazakii...
  23. ncbi Functional significance of factor H binding to Neisseria meningitidis
    Muriel C Schneider
    Centre for Molecular Microbiology and Infection, Imperial College London, UK
    J Immunol 176:7566-75. 2006
    ..meningitidis to avoid complement-mediated killing in the presence of human serum. Therefore, the recruitment of fH provides another mechanism by which this important human pathogen evades host innate immunity...
  24. ncbi Immunogenicity and tolerability of a quadrivalent meningococcal glycoconjugate vaccine in children 2-10 years of age
    S Black
    Center for Global Child Health, Cincinnati Children s Hospital, Cincinnati, Ohio, USA
    Vaccine 28:657-63. 2010
    ..Both vaccines were well tolerated. In children 2-10 years of age, MenACWY-CRM induced a higher immune response than that of MPSV4, and was well tolerated...
  25. pmc Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae
    J N Weiser
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104 4318, USA
    Infect Immun 65:943-50. 1997
    ..In the case of H. influenzae, its primary contribution to pathogenesis does not appear to be antigenic variation to evade host humoral clearance mechanisms...
  26. ncbi Phase III comparison of an investigational quadrivalent meningococcal conjugate vaccine with the licensed meningococcal ACWY conjugate vaccine in adolescents
    Lisa A Jackson
    Group Health Center for Health Studies, Seattle, Washington 98101, USA
    Clin Infect Dis 49:e1-10. 2009
    ..This study compares the safety and immunogenicity of the Novartis Vaccines investigational quadrivalent meningococcal CRM(197) conjugate vaccine, MenACWY-CRM, with the licensed meningococcal conjugate vaccine, Menactra...
  27. pmc Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway
    Jose Yuste
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University St, London WC1E 6JJ, United Kingdom
    Infect Immun 76:3761-70. 2008
    ..These data confirm that the classical pathway is vital for complement-mediated phagocytosis of S. pneumoniae and demonstrate why subjects with a C2 deficiency have a marked increase in susceptibility to S. pneumoniae infections...
  28. ncbi Antibacterial properties of serum from the American alligator (Alligator mississippiensis)
    Mark E Merchant
    Department of Chemistry, McNeese State University, PO Box 90455, Lake Charles, LA 70609, USA
    Comp Biochem Physiol B Biochem Mol Biol 136:505-13. 2003
    ..These data suggest that the antimicrobial properties of alligator serum may be due to an active serum complement system...
  29. pmc Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing
    Elisabeth Kugelberg
    Centre for Molecular Microbiology and Infection, Flowers Building, Armstrong Road, Imperial College London, London SW7 2AZ, United Kingdom
    Vaccine 26:I34-9. 2008
    ..Here we discuss the mechanisms of meningococcal resistance against complement-mediated killing and the influence of both bacterial and host genetic factors...
  30. pmc Brain damage in newborn rat model of meningitis by Enterobacter sakazakii: a role for outer membrane protein A
    Rahul Mittal
    Department of Pediatrics, Division of Infectious Diseases, The Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Lab Invest 89:263-77. 2009
    ..These results suggest that OmpA expression in ES is necessary for the colonization of the gastrointestinal tract and for subsequent survival in blood to cause meningitis...
  31. pmc Persistence of immune responses after a single dose of Novartis meningococcal serogroup A, C, W-135 and Y CRM-197 conjugate vaccine (Menveo®) or Menactra® among healthy adolescents
    Christopher J Gill
    Novartis Vaccines and Diagnostics, Cambridge, MA, USA
    Hum Vaccin 6:881-7. 2010
    ..The proportion of subjects with hSBA titers ≥8 was significantly higher among recipients of MenACWY-CRM than MCV4 for serogroups A, W-135 and Y...
  32. ncbi Generation and characterization of a PhoP homologue mutant of Neisseria meningitidis
    C R Johnson
    School of Biological Sciences, University of Surrey, Guildford, Surrey GU2 5XH, UK
    Mol Microbiol 39:1345-55. 2001
    ..Identification of those genes regulated by the meningococcal PhoP may provide a route towards the identification of virulence genes in the meningococcus...
  33. pmc Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and neisserial heparin binding antigen
    David M Vu
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Vaccine 29:1968-73. 2011
    ..For meningococcal vaccines that target relatively sparsely exposed antigens such fHbp or NHba, non-bactericidal antibodies against individual antigens can cooperate and elicit SBA...
  34. ncbi Immunogenicity and safety of an investigational combined haemophilus influenzae type B-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine
    Terry Nolan
    Vaccine and Immunisation Research Group, Murdoch Children s Research Institute and School of Population Health, University of Melbourne, Victoria, Australia
    Pediatr Infect Dis J 30:190-6. 2011
    ..Neisseria meningitidis serogroups B, C, and Y cause most meningococcal disease in industrialized countries. A Haemophilus influenzae type b-meningococcal serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) was evaluated...
  35. ncbi Randomized trial to assess immunogenicity and safety of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in infants
    Colin D Marchant
    Boston University Medical Center, Boston, MA 02118, USA
    Pediatr Infect Dis J 29:48-52. 2010
    ..Study assessed the immunogenicity and safety of an investigational Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) in infants...
  36. ncbi Immunogenicity and safety of an investigational quadrivalent meningococcal ACWY tetanus toxoid conjugate vaccine in healthy adolescents and young adults 10 to 25 years of age
    Roger Baxter
    Kaiser Permanente Vaccine Study Center, Oakland, CA, USA
    Pediatr Infect Dis J 30:e41-8. 2011
    ..An investigational quadrivalent Neisseria meningitidis serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine (MenACWY-TT) has been developed to expand available options for vaccination against invasive meningococcal disease...
  37. ncbi Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis
    Hanna Jarva
    Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
    J Immunol 174:6299-307. 2005
    ..PorA-expressing strains were also more resistant to C lysis than PorA-negative strains in a serum bactericidal assay. Binding of C4bp thus helps Neisseria meningitidis to escape CP complement activation...
  38. ncbi Safety and immunogenicity of a tetravalent meningococcal serogroups A, C, W-135 and Y conjugate vaccine in adolescents and adults
    Nancy Bermal
    Research Institute for Tropical Medicine, Filinvest Corporate City, Alabang, Muntinlupa City, Philippines
    Hum Vaccin 7:239-47. 2011
    ..The results of this study indicate that ACWY-TT could be used as a third conjugate vaccine in the protection of adolescents against meningococcal disease...
  39. pmc A conserved tetranucleotide repeat is necessary for wild-type expression of the Moraxella catarrhalis UspA2 protein
    Ahmed S Attia
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    J Bacteriol 188:7840-52. 2006
    ..These data confirm that the presence of the AGAT repeats in the 5'-UTR of the uspA2 gene is necessary for both normal expression of the UspA2 protein and serum resistance...
  40. pmc Complement evasion by Borrelia burgdorferi: serum-resistant strains promote C3b inactivation
    A Alitalo
    Department of Bacteriology and Immunology, Haartman Institute and HUCH Laboratory Diagnostics, FIN-00014 University of Helsinki, Finland
    Infect Immun 69:3685-91. 2001
    ..Thus, the serum-resistant B. burgdorferi s.l. strains can circumvent C attack by binding the C inhibitors factor H and FHL-1 to their surfaces and promoting factor I-mediated C3b degradation...
  41. ncbi The emerging pathogen Moraxella catarrhalis interacts with complement inhibitor C4b binding protein through ubiquitous surface proteins A1 and A2
    Therese Nordstrom
    Department of Medical Microbiology, Lund Univerity, Malmo University Hospital, Sweden
    J Immunol 173:4598-606. 2004
    ..catarrhalis retained its cofactor activity as determined by analysis of C4b degradation. Taken together, M. catarrhalis interferes with the classical complement activation pathway by binding C4BP to UspA1 and UspA2...
  42. pmc A critical threshold of meningococcal factor H binding protein expression is required for increased breadth of protective antibodies elicited by native outer membrane vesicle vaccines
    Oliver Koeberling
    Novartis Vaccines, Siena, Italy
    Clin Vaccine Immunol 18:736-42. 2011
    ..Thus, a critical threshold of increased fHbp expression is required for NOMV vaccines to elicit broad serum bactericidal responses, and the antibodies conferring protection are directed primarily at fHbp...
  43. ncbi The complement regulator factor H binds to the surface protein OspE of Borrelia burgdorferi
    J Hellwage
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Haartmaninkatu 3, FIN-00014 Helsinki, Finland
    J Biol Chem 276:8427-35. 2001
    ..Specific binding of factor H to B. burgdorferi sensu stricto OspE may help the pathogen to evade complement attack and phagocytosis...
  44. ncbi The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis
    S Ram
    The Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, MA 02118, USA
    Mol Immunol 36:915-28. 1999
    ..LOS structure may act in concert with capsule to prevent MAC insertion. Meningococcal strains with Class 3 Por preferentially bind factor H, suggesting Class 3 Por acts as a receptor for factor H...
  45. ncbi Sensitivity of Borrelia genospecies to serum complement from different animals and human: a host-pathogen relationship
    Mangesh R Bhide
    Department of Epizootology and Infectious Diseases, University of Veterinary Medicine, Komenskeho 73, Kosice, Slovakia
    FEMS Immunol Med Microbiol 43:165-72. 2005
    ..In short, this study reviews Borrelia-host relationship and its relevance in reservoir competence nature of animals...
  46. pmc Logarithmic phase Escherichia coli K1 efficiently avoids serum killing by promoting C4bp-mediated C3b and C4b degradation
    David G Wooster
    Division of Infectious Diseases, The Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Immunology 117:482-93. 2006
    ..Thus, binding of C4bp appears to be responsible for survival of E. coli K1 in human serum...
  47. pmc LfhA, a novel factor H-binding protein of Leptospira interrogans
    Ashutosh Verma
    Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546, USA
    Infect Immun 74:2659-66. 2006
    ..interrogans during mammalian infection. LfhA may therefore contribute to the resistance of pathogenic leptospires to complement-mediated killing during leptospiremic phases of the disease...
  48. pmc Effects of complement regulators bound to Escherichia coli K1 and Group B Streptococcus on the interaction with host cells
    Ravi Maruvada
    Division of Infectious Diseases, The Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Immunology 124:265-76. 2008
    ..coli, and Factor H, in the case of GBS. Taken together, these results suggest that E. coli and GBS utilize contrasting mechanisms of complement-mediated interactions with their target cells for successful establishment of disease...
  49. ncbi Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system
    Katarzyna Popadiak
    Lund University, Department of Laboratory Medicine, Section of Medical Protein Chemistry, University Hospital Malmo, Malmo, Sweden
    J Immunol 178:7242-50. 2007
    ..At later stages of infection the concentration of proteases is high enough to destroy complement factors and thus render the bacteria resistant to the bactericidal activity of complement...
  50. ncbi Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients
    Elene Haralambous
    Department of Clinical and Molecular Genetics, Institute of Child Health, University College, London, UK
    Scand J Infect Dis 38:764-71. 2006
    ....
  51. pmc Correlation between serum bactericidal activity against Neisseria meningitidis serogroups A, C, W-135 and Y measured using human versus rabbit serum as the complement source
    C J Gill
    Novartis Vaccines and Diagnostics, Cambridge, MA, USA
    Vaccine 30:29-34. 2011
    ..In conclusion, results generated by rSBA did not accurately classify serostatus according to hSBA for serogroups A, W-135 and Y...
  52. ncbi Ionic binding of C3 to the human pathogen Moraxella catarrhalis is a unique mechanism for combating innate immunity
    Therese Nordstrom
    Medical Microbiology, Lund University, Malmo University Hospital, Malmo, Sweden
    J Immunol 175:3628-36. 2005
    ..Interestingly, among the large number of bacteria analyzed, only M. catarrhalis has this unique ability to interfere with the innate immune system of complement by binding C3...
  53. ncbi A randomized, multicenter, open-label clinical trial to assess the immunogenicity of a meningococcal C vaccine booster dose administered to children aged 14 to 18 months
    Javier Diez-Domingo
    CSISP, Centro Superior de Investigacion en Salud Publica Center for Public Health Research, Valencia, Spain
    Pediatr Infect Dis J 29:148-52. 2010
    ..A booster meningococcal C (MenC) vaccine dose is recommended after the first year of life. The objective of this study was to assess its immunogenicity and factors that modify the immunoresponse...
  54. ncbi A novel interaction of outer membrane protein A with C4b binding protein mediates serum resistance of Escherichia coli K1
    Nemani V Prasadarao
    Division of Infectious Diseases, Childrens Hospital, and Keck School of Medicine, University of Southern California, Los Angeles 90027, USA
    J Immunol 169:6352-60. 2002
    ..A compelling observation in this study is that synthetic peptides corresponding to CCP3 sequences block the binding of C4bp to OmpA and also significantly enhance serum bactericidal activity...
  55. ncbi Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi
    Chad S Brooks
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Immunol 175:3299-308. 2005
    ..burgdorferi. The combined data led us to conclude that CRASP-1 expression is necessary for B. burgdorferi to resist killing by human serum...
  56. ncbi Identification of alternative pathway serum complement activity in the blood of the American alligator (Alligator mississippiensis)
    Mark E Merchant
    Department of Chemistry, McNeese State University, P O Box 90455, Lake Charles, Louisiana 70609, USA
    Comp Biochem Physiol B Biochem Mol Biol 141:281-8. 2005
    ..These data suggest that the antibiotic properties of alligator serum are partially due to the presence of a complement-facilitated humoral immune response analogous to that described in mammalian systems...
  57. pmc Role of YadA, Ail, and Lipopolysaccharide in Serum Resistance of Yersinia enterocolitica Serotype O:3
    Marta Biedzka-Sarek
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P O Box 21, 00014, Finland
    Infect Immun 73:2232-44. 2005
    ..In normal serum, the bacteria were less resistant to C3b deposition. However, no direct correlation between the C3 deposition pattern and bacterial resistance was observed...
  58. ncbi Pseudomonas aeruginosa and Burkholderia cenocepacia infections in patients affected by cystic fibrosis: serum resistance and antibody response
    D Savoia
    Department of Clinical and Biological Sciences, University of Torino, Orbassano, Italy
    Immunol Invest 37:19-27. 2008
    ..aeruginosa was higher than that against B. cenocepacia. The contribution of these data to the assessment of the importance of the humoral immune response in CF pulmonary infections by Pseudomonas and Burkholderia is briefly discussed...
  59. pmc Immunogenicity of, and immunologic memory to, a reduced primary schedule of meningococcal C-tetanus toxoid conjugate vaccine in infants in the United kingdom
    Ray Borrow
    PHLS Meningococcal Reference Unit, Withington Hospital, Manchester, United Kingdom
    Infect Immun 71:5549-55. 2003
    ..This study provides the first evidence that the number of doses of MCC-TT used in infant immunization schedules could be decreased...
  60. ncbi In vitro induction of memory-driven responses against Neisseria meningitidis by priming with Neisseria lactamica
    S Sanchez
    Departamento de Microbiologia y Parasitologia, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Vaccine 20:2957-63. 2002
    ..lactamica and other species, hampering the natural mechanisms of acquisition of immunity to the meningococci, and leaving its ecological niche free for colonization by undesirable microorganisms...
  61. pmc Human pathogenic Borrelia spielmanii sp. nov. resists complement-mediated killing by direct binding of immune regulators factor H and factor H-like protein 1
    Pia Herzberger
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul Ehrlich Str 40, D 60596 Frankfurt, Germany
    Infect Immun 75:4817-25. 2007
    ..This is the first report describing an immune evasion mechanism utilized by B. spielmanii sp. nov., and it demonstrates the capture of human immune regulators to resist complement-mediated killing...
  62. ncbi Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization
    G R Jones
    Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, United Kingdom
    J Infect Dis 178:451-9. 1998
    ..The subtype specificity of the bactericidal response to meningococci and the stability of expression of the class 1 protein have important implications for the design of vaccines for prevention of serogroup B meningococcal disease...
  63. pmc Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis
    Michal Potempa
    Department of Laboratory Medicine, Section of Medical Protein Chemistry, University Hospital Malmo, Lund University, Malmo, Sweden
    J Immunol 181:5537-44. 2008
    ....
  64. ncbi Protective immunization against group B meningococci using anti-idiotypic mimics of the capsular polysaccharide
    Concetta Beninati
    Dipartimento di Patologia e Microbiologia Sperimentale, Universita degli Studi di Messina, Messina, Italy
    J Immunol 172:2461-8. 2004
    ..In conclusion, we have produced anti-idiotypic scFvs that mimic a protective MenB CP epitope and may be useful in the development of an alternative group B meningococcal vaccine...
  65. ncbi Partial characterization of phagocytic activity in neutrophils of the nine-banded armadillo Dasypus novemcinctus
    Marcela López-Hurtado
    Laboratorio de Microbiología Veterinaria de la Escuela Nacional de Ciencias Biológicas del IPN, Prol de Carpio y Plan de Ayala s n, Mexico City, c p 11340, Mexico
    Vet Immunol Immunopathol 106:269-75. 2005
    ..This deficiency could be a cause so that the armadillo neutrophils do not respond quickly to invading microorganism...
  66. ncbi The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster response
    Geraldine Blanchard Rohner
    Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
    J Immunol 180:2165-73. 2008
    ..These findings suggest that these two parameters are good markers of B cell responses to priming and can be used as predictors of long term humoral immunity induced by glycoconjugate vaccines received in early infancy...
  67. ncbi Immunologic memory response induced by a meningococcal serogroup C conjugate vaccine using the P64k recombinant protein as carrier
    María Guirola
    Vaccines Division, Centro de Ingenieria Genetica y Biotechnologia, Ciudad de La Habana, Cuba
    FEMS Immunol Med Microbiol 46:169-79. 2006
    ....
  68. ncbi Effect of 2-hydroxyethyl-methacrylate (HEMA) on the phagocytic and respiratory burst activity of human neutrophils and monocytes
    Jennie Andersson
    Section for Oral Microbiology and Immunology, Department of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Eur J Oral Sci 116:369-74. 2008
    ..In conclusion, HEMA did not affect the phagocytosis activity of neutrophils; however, the ability of the cells to kill internalized prey was significantly reduced...
  69. ncbi Vaccine potential of the Neisseria meningitidis lactoferrin-binding proteins LbpA and LbpB
    Annika Pettersson
    Department of Molecular Microbiology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Vaccine 24:3545-57. 2006
    ..Our results show that both proteins are immunogenic and able to induce bactericidal antibodies, but that the cross-reactivity of these antibodies is limited...
  70. pmc Comparison and correlation of neisseria meningitidis serogroup B immunologic assay results and human antibody responses following three doses of the Norwegian meningococcal outer membrane vesicle vaccine MenBvac
    Jamie Findlow
    Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Laboratory, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, United Kingdom
    Infect Immun 74:4557-65. 2006
    ..These results emphasize the need for standardized methodologies that would allow a more robust comparison of assays between laboratories and promote their further evaluation as correlates of protection against MenB disease...
  71. ncbi Co-ordinate action of bacterial adhesins and human carcinoembryonic antigen receptors in enhanced cellular invasion by capsulate serum resistant Neisseria meningitidis
    Helen A Rowe
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Cell Microbiol 9:154-68. 2007
    ....
  72. ncbi Immune memory in children previously vaccinated with an experimental quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine
    Michael Pichichero
    University of Rochester, Rochester, NY, USA michael_pichichero edu
    Pediatr Infect Dis J 25:995-1000. 2006
    ..A subset of participants, 2 to 3 years of age at the initial vaccination, was evaluated for persistence of antibody, immune memory, and antibody avidity...
  73. pmc Persisting immune responses indicating long-term protection after booster dose with meningococcal group B outer membrane vesicle vaccine
    Berit Feiring
    Division of Infectious Disease Control, Norwegian Institute of Public Health NIPH, P O Box 4404, Nydalen, N 0403 Oslo, Norway
    Clin Vaccine Immunol 13:790-6. 2006
    ..This study confirmed the good immunogenicity of the primary course of MenBvac and demonstrated prolonged persistence and increased cross-reactivity of functional antibodies elicited by a booster dose...
  74. ncbi Effects of dietary vitamin C on neutrophil function and responses to intramammary infusion of lipopolysaccharide in periparturient dairy cows
    W P Weiss
    Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA
    J Dairy Sci 90:731-9. 2007
    ..Supplemental vitamin C had no effect on neutrophil phagocytosis or bacterial kill. Dietary vitamin C reduced the milk somatic cell count but did not affect the febrile response or milk production following LPS infusion...
  75. ncbi New zealand epidemic strain meningococcal B outer membrane vesicle vaccine in children aged 16-24 months
    Sharon Wong
    The University of Auckland, Auckland, New Zealand
    Pediatr Infect Dis J 26:345-50. 2007
    ..7b,4 since 1991. Children younger than 5 years are at highest risk. Previous serogroup B outer membrane vesicle (OMV) strain specific vaccines have shown variable efficacy in this age group...
  76. pmc Additive and synergistic bactericidal activity of antibodies directed against minor outer membrane proteins of Neisseria meningitidis
    Vincent E Weynants
    GlaxoSmithKline Biologicals, Rue de l Institut 89, B 1330 Rixensart, Belgium
    Infect Immun 75:5434-42. 2007
    ..With minor OMPs, this threshold is reached when more than one antigen is targeted, and this allows cross-protection...
  77. pmc Agonists of Toll-like receptors 3, 4, 7, and 9 are candidates for use as adjuvants in an outer membrane vaccine against Neisseria meningitidis serogroup B
    Floris Fransen
    Laboratory for Vaccine Research, The Netherlands Vaccine Institute, Antonie van Leeuwenhoeklaan 11 13, 3720 AL Bilthoven, The Netherlands
    Infect Immun 75:5939-46. 2007
    ....
  78. pmc Immunoglobulin G subclass response to a meningococcal quadrivalent polysaccharide-diphtheria toxoid conjugate vaccine
    Helen Findlow
    Vaccine Evaluation Unit, Health Protection Agency North West, P O Box 209, Clinical Sciences Building, Manchester Royal Infirmary, Manchester, M13 9WZ, United Kingdom
    Clin Vaccine Immunol 13:507-10. 2006
    ..Further studies on IgG subclasses following meningococcal polysaccharide and conjugate vaccination are needed...
  79. pmc Understanding the immune responses to the meningococcal strain-specific vaccine MeNZB measured in studies of infants
    N Ruijne
    Institute of Environmental Science and Research ESR, P O Box 50 348, Porirua, New Zealand
    Clin Vaccine Immunol 13:797-801. 2006
    ..00012) from 42.4% (95% CI, 39.1 to 45.3%) postvaccination to 50.4% (95% CI, 47.2 to 53.6%) 4 months later. A fourth dose of MeNZB is now being given to young infants at 10 months of age...
  80. pmc Immunization with recombinant Opc outer membrane protein from Neisseria meningitidis: influence of sequence variation and levels of expression on the bactericidal immune response against meningococci
    K A Jolley
    Molecular Microbiology Group, Division of Cell and Molecular Medicine, University of Southampton Medical School, Southampton General Hospital, United Kingdom
    Infect Immun 69:3809-16. 2001
    ..The magnitude of the bactericidal effect was strongly influenced by the level of expression of the Opc protein and was abolished by limited variation in the sequence of the protein expressed by heterologous strains...
  81. ncbi Immunogenicity and immunologic memory of meningococcal C conjugate vaccine in premature infants
    Clare L Collins
    St George s Hospital Medical School, London, United Kingdom
    Pediatr Infect Dis J 24:966-8. 2005
    ..K. routine immunization schedule in 1999. This study is the first to describe both persistence of antibody and evidence for induction of immune memory using meningococcal C conjugate (MCC) vaccine in preterm infants...
  82. ncbi Green fluorescent protein-expressing Escherichia coli as a selective probe for HOCl generation within neutrophils
    Amy M Palazzolo
    Department of Chemistry, Washington State University, Pullman, Washington 99164 4630, USA
    Biochemistry 44:6910-9. 2005
    ....
  83. ncbi Protective effect of a traditional Chinese medicine, xiao-chai-hu-tang (Japanese name: shosaiko-to), on Pseudomonas aeruginosa infection in mice
    T Kawakita
    Department of Immunology, Kyushu University, Fukuoka, Japan
    Immunopharmacol Immunotoxicol 9:523-40. 1987
    ..These results suggested that shosaiko-to could augment nonspecific resistance to a variety of bacteria to which antibody plays an effective role...
  84. ncbi Safety and immunogenicity of meningococcus serogroup C conjugate vaccine administered as a primary or booster vaccination to healthy four-year-old children
    Jodie McVernon
    Oxford Vaccine Group, Department of Pediatrics, John Radcliffe Hospital, Oxford, UK
    Pediatr Infect Dis J 21:747-53. 2002
    ..Little information exists regarding antibody persistence or immunologic memory after infant vaccination or response to a first dose at 4 years...
  85. pmc Sequential immunization with vesicles prepared from heterologous Neisseria meningitidis strains elicits broadly protective serum antibodies to group B strains
    Gregory R Moe
    Children s Hospital Oakland Research Institute, Oakland, California 94609 1673, USA
    Infect Immun 70:6021-31. 2002
    ..meningitidis strains. An NspA-based vaccine prepared from protein expressed by Neisseria also may be more effective than the corresponding recombinant protein made in Escherichia coli...
  86. pmc A glycoconjugate vaccine for Neisseria meningitidis induces antibodies in human infants that afford protection against meningococcal bacteremia in a neonate rat challenge model
    Kenneth T Mountzouros
    Wyeth Research, West Henrietta, New York 14586 9728, USA
    Infect Immun 70:6576-82. 2002
    ..meningitidis serogroup C PS IgG antibody induced by this glycoconjugate vaccine had in vitro functional activity (as determined by a SBA) and also afforded protection against meningococcal bacteremia in an animal model...
  87. ncbi Assay parameters and methods of data analysis for the comparison of complement sources in the Neisseria meningitidis serogroup C serum bactericidal assay
    Luis Jodar
    World Health Organisation, Switzerland
    Biologicals 30:323-9. 2002
  88. pmc Age-related disparity in functional activities of human group C serum anticapsular antibodies elicited by meningococcal polysaccharide vaccine
    Shannon L Harris
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Infect Immun 71:275-86. 2003
    ....
  89. ncbi Killing of Escherichia coli strains from clinical specimens in human serum and polymorphonuclear leucocytes
    Surinder Kumar
    Department of Microbiology Department, Maulana Azad Medical College, New Delhi
    Indian J Pathol Microbiol 45:173-5. 2002
    ..01). Thus, clinical significance of Escherichia coli strains from different sources can be determined by the resistance to the bactericidal effect of human serum and killing in polymorphonuclear leucocytes...
  90. pmc Antibody specificities and effect of meningococcal carriage in icelandic teenagers receiving the Norwegian serogroup B outer membrane vesicle vaccine
    Elisabeth Wedege
    Division of Infectious Disease Control, Norwegian Institute of Public Health, N 0403 Oslo, Norway
    Infect Immun 71:3775-81. 2003
    ..19,15 PorA on blots. Although vaccination did not elicit bactericidal activity to the serotype 15 PorB, most carriers of serotype 15 strains showed > or =4-fold increases in SBA to this antigen...
  91. pmc Preparation and characterization of group A meningococcal capsular polysaccharide conjugates and evaluation of their immunogenicity in mice
    Zhigang Jin
    Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 71:5115-20. 2003
    ..0- microg dose elicited a higher GM IgG anti-GAMP than the 2.5- microg dose. Low levels of anti-GAMP were elicited by GAMP alone. GAMP(CDAP)-AHBSA elicited bactericidal activity roughly proportional to the level of IgG anti-GAMP...
  92. pmc Lipooligosaccharide and polysaccharide capsule: virulence factors of Neisseria meningitidis that determine meningococcal interaction with human dendritic cells
    Alexandra Unkmeir
    Institut für Hygiene und Mikrobiologie, Universität Würzburg Universitätsklinik für Frauenheilkunde Dermatologische Universitätsklinik, 97080 Wurzburg, Germany
    Infect Immun 70:2454-62. 2002
    ..meningitidis and phagocytosis to some extent. Hence, LOS sialylation and capsule expression are independent mechanisms protecting N. meningitidis from the phagocytic activity of human DC...
  93. ncbi Antibody increases phagocytosis and killing of Lactococcus garvieae by rainbow trout (Oncorhynchus mykiss, L.) macrophages
    Andrew C Barnes
    The Marine Laboratory, Aberdeen, Scotland, UK
    Fish Shellfish Immunol 12:181-6. 2002
    ..garvieae in the presence of specific antibody and may in part explain the protective effect of antibody previously reported against this disease...
  94. pmc Recurrent meningococcal infections associated with a functional deficiency of the C8 component of human complement
    N Matthews
    Clin Exp Immunol 39:53-9. 1980
    ....
  95. ncbi The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide
    P Elsbach
    Department of Medicine and Microbiology, New York University School of Medicine, New York
    Immunobiology 187:417-29. 1993
    ..Recombinant forms of both proteins protect animals against the lethal effects of administered LPS...
  96. ncbi Activity of human IgG and IgA subclasses in immune defense against Neisseria meningitidis serogroup B
    G Vidarsson
    Department of Immunology, Medarex Europe, Genmab, and Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 166:6250-6. 2001
    ..These studies reveal unique and nonoverlapping roles for IgG and IgA Abs in defense against meningococcal infections...
  97. ncbi Evaluation of cross-reactive antigens as determinants of cross-bactericidal activity in pathogenic and commensal Neisseria
    S Sanchez
    Departamento de Microbiologia, Facultad de Farmacia, Universidad de Santiago de Compostela, 15706, Santiago de Compostela, Spain
    Vaccine 19:3390-8. 2001
    ....
  98. ncbi Immunogenicity of recombinant class 1 protein from Neisseria meningitidis refolded into phospholipid vesicles and detergent
    O Niebla
    Division of Vaccines, Centre for Genetic Engineering and Biotechnology, PO Box 6162, Ave 31, Apartado 6162, 10600, La Havana, Cuba
    Vaccine 19:3568-74. 2001
    ..These results suggest that in spite of being a denaturing agent, it is possible to use SDS to reconstitute the P1 protein in a conformation that exposes the immunodominat regions...
  99. ncbi Influence of prior meningococcal C polysaccharide vaccination on the response and generation of memory after meningococcal C conjugate vaccination in young children
    R Borrow
    Public Health Laboratory Service Meningococcal Reference Unit, Withington Hospital, Manchester, United Kingdom
    J Infect Dis 184:377-80. 2001
    ....
  100. ncbi Meningococcal B vaccine development and evaluation of efficacy
    Loek van Alphen
    Netherlands Vaccine Institute, Bilthoven, The Netherlands
    Hum Vaccin 4:158-61. 2008
    ....
  101. pmc Opsonophagocytosis of fluorescent polystyrene beads coupled to Neisseria meningitidis serogroup A, C, Y, or W135 polysaccharide correlates with serum bactericidal activity
    Joseph Martinez
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Diagn Lab Immunol 9:485-8. 2002
    ..OPA titers significantly correlated with serum bactericidal assay titers for all serogroups tested (mean r = 0.96; P < 0.001). OPA could be used in meningococcal vaccine evaluation...

Research Grants44

  1. Neisseria meningitidis antigens expressed in infection
    Dan Granoff; Fiscal Year: 2005
    ..meningitidis disease, including group B strains for which there is currently no vaccine available. Also, characterization of gene expression in an in vivo model will lead to a better understanding of meningococcal pathogenesis. ..
  2. Molecular basis meningococcal group A capsular immunity
    Dan Granoff; Fiscal Year: 2007
    ..abstract_text> ..
  3. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  4. HUMAN SERUM AND PROTECTION AGAINST BORDETELLA PERTUSSIS
    Alison Weiss; Fiscal Year: 2004
    ..In addition, they will assess if people are more likely to generate neutralizing antibodies if immunized with genetically toxoided toxin, chemically toxoided toxin, or by natural disease. ..
  5. BACTERIAL PHOSPHORYLCHOLINE AND PATHOGENESIS
    Jeffrey Weiser; Fiscal Year: 2009
    ..Aim 3 will determine the effects of the immune response to ChoP on colonization, where our findings demonstrate that expression of ChoP is most important to pathogenesis. ..
  6. Shiga Toxin Encoding Phage and Intestinal E.coli
    Alison Weiss; Fiscal Year: 2004
    ..coli; and 2) Develop methods to convert intestinal flora to phage resistance using a mouse model of disease. ..
  7. Competition Among Bacterial Resiratory Pathogens
    Jeffrey Weiser; Fiscal Year: 2004
    ..Future strategies to decrease disease burden by reducing carriage could result from a greater understanding of interactions between species. ..
  8. Biologic Activities of the pertusis toxin B-pentamer
    ALISON A contact WEISS; Fiscal Year: 2010
    ....
  9. Training in Biologic Threat Agents
    Alison Weiss; Fiscal Year: 2007
    ..abstract_text> ..
  10. Novel Context-Activated Protide Anti-Infectives
    Michael Yeaman; Fiscal Year: 2008
    ..These advances would represent major breakthroughs in the prevention and treatment of these common and increasingly difficult-to-treat infections. [unreadable] [unreadable] [unreadable]..
  11. Role of DPPI & Serine Proteases in Inflammatory Diseases
    Christine Pham; Fiscal Year: 2007
    ..We also hypothesize that decreased expression of complement regulators in the kidney mav be a determinant that influences the severity of tissue damage in the target organ. ..
  12. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..abstract_text> ..
  13. VOLTAGE-GATED PROTON CHANNELS IN HUMAN NEUTROPHILS
    THOMAS DECOURSEY; Fiscal Year: 2008
    ..5) We will identify the proton channel molecule and gene. ..
  14. Mechanisms of MHC-II antigen processing of HIV in macrophages and dendritic cells
    DAVID CANADAY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  15. Innate Immune Receptors in Host Responses to Neisseria
    ROBIN INGALLS; Fiscal Year: 2009
    ..abstract_text> ..
  16. DEVELOPMENT OF STAPHYLOCOCCALCIDAL HUMAN PEPTIDES
    William Shafer; Fiscal Year: 2008
    ..This information should help in the development of new effective peptide-based drugs that could be used in the future to combat staphylococcal diseases caused by antibiotic-resistant strains. ..
  17. Interaction of Chalmydia with Innate Immune Receptors
    ROBIN INGALLS; Fiscal Year: 2009
    ..abstract_text> ..
  18. 2009 Multi-drug Efflux Systems Gordon Research Conference
    William Shafer; Fiscal Year: 2008
    ..The GRC will focus on these specific key areas related to multi-drug efflux pumps in resistance. [unreadable] [unreadable] [unreadable]..
  19. Innate Immunity and Herpes Simplex Pathogensis
    Robert Finberg; Fiscal Year: 2009
    ..abstract_text> ..
  20. Sexually Transmitted Infections & Antimicrobial Peptides
    William Shafer; Fiscal Year: 2009
    ..abstract_text> ..
  21. Pathogenesis of myocarditis
    Robert Finberg; Fiscal Year: 2007
    ..At the same time we will define the roles of CD14, and several TLRs (especially TLR2, TLR4 and TLR7) in the response to CBS and its regulation in the development of myocarditis. [unreadable] [unreadable]..
  22. CORE FACILITY RESEARCH PEPTIDE SYNTHESIZER
    Michael Yeaman; Fiscal Year: 2001
    ..Therefore, the proposed instrument will significantly enhance the efficiency and diversity of SPPS required for NIH-sponsored and hypothesis-driven research. ..
  23. Differential Gene Expresion in Yersinia pestis
    Kathleen McDonough; Fiscal Year: 2005
    ..Characterization of Y. pestis-specific genes and their proteins in future studies will also identify potential mechanisms by which Y. pestis emerged as a new pathogen distinct from Yptb. ..
  24. Role of Complement Proteins in E. coli Meningitis
    PRASADARAO NEMANI; Fiscal Year: 2003
    ..coli invasion of BMEC, and 2. To assess the effect of anti-OmpA antibody, OmpA-peptides, and C4BP-peptides on E. coli invasion of BMEC in the newborn rat model of hematogenous meningitis. ..
  25. RovA regulon of Yersinia pestis
    VIRGINIA MILLER; Fiscal Year: 2003
    ..pestis, and (2) Identification of the Y. pestis RovA regulated gene products; we predict some of these rovA regulated genes will be unique to Y. pestis (compared to Y. enterocolitica or Salmonella). ..
  26. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2006
    ..Expression profiling of phagocytosed bacteria appears to provide useful information about conditions in the phagocytic vacuole and about important bacterial defenses mounted in response to this hostile environment. ..
  27. VOLTAGE-GATED PROTON CHANNELS IN ALVEOLAR EPITHELIUM
    THOMAS DECOURSEY; Fiscal Year: 2003
    ..Demonstration that H+ current fluctuations result from stochastic gating of H+ channels will provide strong evidence that the molecule is an ion channel rather than a carrier. ..
  28. Control of virulence in Neisseria meningitidis
    Yih Ling Tzeng; Fiscal Year: 2009
    ..meningitidis and are important to the development of new approaches for meningococcal disease prevention and treatment. ..
  29. Hunting the PLUNCs, a novel innate immune family
    ELIZABETH LECLAIR; Fiscal Year: 2005
    ..Taken together, the PLUNC proteins represent a novel family of therapeutic targets for the study of innate immunity and the treatment of infection. ..
  30. MICROBICIDAL PROTEINS FROM PLATELETS
    Michael R Yeaman; Fiscal Year: 2010
    ..In turn, these insights will accelerate development of novel strategies to prevent or treat serious infections, particularly those caused by antibiotic-resistant pathogens. ..
  31. Physical Activity, Aging and Immune Function
    Jeffrey Woods; Fiscal Year: 2005
    ..In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function. ..
  32. DETERMINANTS IN PLATELET MICROBICIDAL PROTEINS
    Michael Yeaman; Fiscal Year: 2004
    ..Thus, these studies will significantly advance our understanding of antimicrobial host defense, and may yield new modes for its amplification. ..
  33. CD14 Signaling and Activation of Innate Immune Response
    Robert Finberg; Fiscal Year: 2003
    ..These studies will help to define how host invasion by microbes leads to septic shock and may provide novel targets for the design of therapeutic interventions against the life-threatening conditions associated with bacterial sepsis. ..
  34. CAR PROTEIN AND AUTO IMMUNITY
    Robert Finberg; Fiscal Year: 2002
    ..We plan to define the role of this protein in the induction of auto-immune disease and use transgenic and knock-out mice to define the mechanisms by which viruses stimulate autoimmune responses. ..
  35. TLRs in Innate Immunity to Viral Infection
    Robert Finberg; Fiscal Year: 2006
    ..These studies should enable us to better understand the pathophysiology of viral infections. ..
  36. Mucosal immune response to oral cholera vaccine Peru 15
    Firdausi Qadri; Fiscal Year: 2007
    ..cholerae. ..
  37. GONOCOCCI: GENETICS OF RESISTANCE TO PMN PROTEINS
    William Shafer; Fiscal Year: 2009
    ..abstract_text> ..
  38. NICHD Institutional Training for Pediatricians
    Kathryn Edwards; Fiscal Year: 2007
    ..3.) Evaluate the success of the training program through both process and outcomes evaluation. (4.) Implement continuous quality improvement procedures that will enhance the PPOR components, curriculum, and overall program. ..
  39. Dysfuntional antigen presenting cell responses to influenza in geriatric individu
    DAVID CANADAY; Fiscal Year: 2008
    ..Ag processing and presentation efficiency of B cells is important for them to receive optimal costimulation from CD4+ T helper cells. [unreadable] [unreadable] [unreadable]..
  40. Autotransporter proteins and virulence of Y. pestis
    VIRGINIA MILLER; Fiscal Year: 2006
    ..Functional analysis of the Yaps. We will begin to investigate the function of the Yaps by testing E. coli expressing individual Yaps for a variety of known functions previously associated with autotransporter proteins. ..
  41. Antigen Processing in HIV-infected Individuals
    DAVID CANADAY; Fiscal Year: 2006
    ..e. HIV-induced deficits in both APC and T cells were potentially present), our studies will provide the first well-controlled comparison of APC function in HIV+ and HIV- persons. ..
  42. CD8+ T CELLS AND MYCOPLASMA TUBERCULOSIS
    DAVID CANADAY; Fiscal Year: 2003
    ..Aim 3. To characterize the functional CD8+ T cell responses to specific proteins and peptides from in patients with active M. tuberculosis infection. ..
  43. Virulence Networks in Salmonella
    VIRGINIA MILLER; Fiscal Year: 2005
    ..Aim 3. To identify other effectors secreted by the SPI1 type III secretion pathway by identifying InvF regulated genes. These will be characterized for their role in virulence related assays. ..