mucosal immunity

Summary

Summary: Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.

Top Publications

  1. ncbi IL-22 in mucosal immunity
    W Ouyang
    Department of Immunology, South San Francisco, California, USA
    Mucosal Immunol 1:335-8. 2008
  2. pmc A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 457:722-5. 2009
  3. pmc IgT, a primitive immunoglobulin class specialized in mucosal immunity
    Yong an Zhang
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Nat Immunol 11:827-35. 2010
  4. pmc A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin
    Lori M Neal
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York 12208, USA
    Infect Immun 78:552-61. 2010
  5. ncbi Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
    Emmanuel Treiner
    Laboratoire d Immunologie and INSERM U520, Institut Curie, Paris 75005, France
    Nature 422:164-9. 2003
  6. ncbi Airway delivery of soluble mycobacterial antigens restores protective mucosal immunity by single intramuscular plasmid DNA tuberculosis vaccination: role of proinflammatory signals in the lung
    Mangalakumari Jeyanathan
    Centre for Gene Therapeutics, M G DeGroote Institute for Infectious Disease Research, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 181:5618-26. 2008
  7. ncbi Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    Hiromasa Hamada
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 168:57-64. 2002
  8. ncbi The role of Th1/Th2 polarization in mucosal immunity
    Markus F Neurath
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
    Nat Med 8:567-73. 2002
  9. ncbi Dual oxidase in mucosal immunity and host-microbe homeostasis
    Yun Soo Bae
    Division of Life and Pharmaceutical Science, Department of Life Science, Department of Bioinspired Science, Ewha Woman s University, Seoul 120 750, South Korea
    Trends Immunol 31:278-87. 2010
  10. pmc Critical issues in mucosal immunity for HIV-1 vaccine development
    Barton F Haynes
    Duke Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    J Allergy Clin Immunol 122:3-9; quiz 10-1. 2008

Detail Information

Publications270 found, 100 shown here

  1. ncbi IL-22 in mucosal immunity
    W Ouyang
    Department of Immunology, South San Francisco, California, USA
    Mucosal Immunol 1:335-8. 2008
    ..Consequently, the restoration of tissue homeostasis helps to attenuate the inflammatory responses involving various immune cells...
  2. pmc A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 457:722-5. 2009
    ....
  3. pmc IgT, a primitive immunoglobulin class specialized in mucosal immunity
    Yong an Zhang
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Nat Immunol 11:827-35. 2010
    ..IgT coated most intestinal bacteria. As IgT and IgA are phylogenetically distant immunoglobulins, their specialization into mucosal responses probably occurred independently by a process of convergent evolution...
  4. pmc A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin
    Lori M Neal
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York 12208, USA
    Infect Immun 78:552-61. 2010
    ..serum antibodies directed against residues 161 to 175 on RTA are sufficient to confer both systemic and mucosal immunity to ricin...
  5. ncbi Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
    Emmanuel Treiner
    Laboratoire d Immunologie and INSERM U520, Institut Curie, Paris 75005, France
    Nature 422:164-9. 2003
    ..This indicates that MAIT cells are probably involved in the host response at the site of pathogen entry, and may regulate intestinal B-cell activity...
  6. ncbi Airway delivery of soluble mycobacterial antigens restores protective mucosal immunity by single intramuscular plasmid DNA tuberculosis vaccination: role of proinflammatory signals in the lung
    Mangalakumari Jeyanathan
    Centre for Gene Therapeutics, M G DeGroote Institute for Infectious Disease Research, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 181:5618-26. 2008
    ..Our study holds implication for the future design of DNA vaccination strategies against intracellular infections...
  7. ncbi Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    Hiromasa Hamada
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 168:57-64. 2002
    ..These findings indicate that ILF, PP, and CP constitute three distinct organized gut-associated lymphoid tissues that reside in the lamina propria of the mouse small intestine...
  8. ncbi The role of Th1/Th2 polarization in mucosal immunity
    Markus F Neurath
    Laboratory of Immunology, I Department of Medicine, University of Mainz, Mainz, Germany
    Nat Med 8:567-73. 2002
    b>Mucosal immunity relies on the delicate balance between antigen responsiveness and tolerance. The polarization of T helper cells plays a key role in maintaining or disrupting this equilibrium.
  9. ncbi Dual oxidase in mucosal immunity and host-microbe homeostasis
    Yun Soo Bae
    Division of Life and Pharmaceutical Science, Department of Life Science, Department of Bioinspired Science, Ewha Woman s University, Seoul 120 750, South Korea
    Trends Immunol 31:278-87. 2010
    ..Recent progress has revealed that dual oxidase (DUOX) plays a key role in mucosal immunity in organisms that range from flies to humans...
  10. pmc Critical issues in mucosal immunity for HIV-1 vaccine development
    Barton F Haynes
    Duke Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    J Allergy Clin Immunol 122:3-9; quiz 10-1. 2008
    ..Thus basic and translational research to understand why current vaccines have failed and elucidation of new mechanisms of virus control at mucosal surfaces is essential for eventual successful development of a preventive HIV-1 vaccine...
  11. ncbi Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, CH8091 Zurich, Switzerland
    Science 303:1662-5. 2004
    ....
  12. pmc Mucosal vaccine made from live, recombinant Lactococcus lactis protects mice against pharyngeal infection with Streptococcus pyogenes
    Praveen Mannam
    Department of Microbiology, Oregon State University, Corvallis, Oregon 97330 3804, USA
    Infect Immun 72:3444-50. 2004
    ..In conclusion, mucosal vaccination with LL-CRR produced CRR-specific salivary IgA and serum IgG, prevented pharyngeal infection with S. pyogenes, and promoted survival...
  13. pmc A functional polymeric immunoglobulin receptor in chicken (Gallus gallus) indicates ancient role of secretory IgA in mucosal immunity
    Willemien H Wieland
    Laboratory of Molecular Recognition and Antibody Technology, Wageningen University, P O Box 8123, 6700 ES Wageningen, The Netherlands
    Biochem J 380:669-76. 2004
    ..The presence of pIgR in chicken suggests that this gene has evolved before the divergence of birds and reptiles, indicating that secretory Igs may have a prominent role in first line defence in various non-mammalian species...
  14. pmc Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge
    Willy M J M Bogers
    Department of Virology, Biomedical Primate Research Centre BPRC, P O Box 3306, 2280 GH Rijswijk, The Netherlands
    Virology 382:217-25. 2008
    ..Vaccine induced protection did not correlate with the type of boost nor T-cell responses, but rather with the Nab titer prior to exposure...
  15. pmc Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius
    Ann M O'Hara
    Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
    Immunology 118:202-15. 2006
    ..infantis or L. salivarius, these commensal bacteria exert immunomodulatory effects on intestinal immune cells that mediate host responses to flagellin and enteric pathogens...
  16. ncbi Mucosal vaccines: the promise and the challenge
    Marian R Neutra
    GI Cell Biology Research Laboratory, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 6:148-58. 2006
    ..These advances promise to accelerate the development and testing of new mucosal vaccines against many human diseases including HIV/AIDS...
  17. ncbi Interaction of antigens and antibodies at mucosal surfaces
    M E Lamm
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Annu Rev Microbiol 51:311-40. 1997
    ..Finally, because of advances in monoclonal antibody technology, topical application of antibodies to mucosal surfaces has significant potential for preventing and treating infections...
  18. pmc A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration
    Shinichi Sekine
    Department of Pediatric Dentistry and Microbiology, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 180:8126-34. 2008
    ..of a naked cDNA plasmid expressing Flt3 ligand (FL) cDNA (pFL) enhanced CD4(+) Th2-type, cytokine-mediated mucosal immunity and increased lymphoid-type dendritic cell (DC) numbers...
  19. pmc Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    Heather L Cash
    Center for Immunology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1126-30. 2006
    ..We propose that these proteins represent an evolutionarily primitive form of lectin-mediated innate immunity, and that they reveal intestinal strategies for maintaining symbiotic host-microbial relationships...
  20. ncbi Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling
    Raina N Fichorova
    Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:2424-32. 2002
    ..These data demonstrate that the response to N. gonorrhoeae and other Gram-negative bacteria at the mucosal surface of the female genital tract occurs in the absence of endotoxin recognition and TLR4-mediated signaling...
  21. pmc Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin
    Michael A Bachman
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    PLoS Pathog 5:e1000622. 2009
    ..Therefore, Lcn2 may represent a novel mechanism of sensing microbial metabolism to modulate the host response appropriately...
  22. pmc Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, and the Oregon National Primate Research Center, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Nat Med 15:293-9. 2009
    ..These data suggest a new paradigm for AIDS vaccine development--vaccines capable of generating and maintaining HIV-specific TEM cells might decrease the incidence of HIV acquisition after sexual exposure...
  23. ncbi Commensal host-bacterial relationships in the gut
    L V Hooper
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Science 292:1115-8. 2001
    ....
  24. pmc Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization
    Tera L McCool
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    Infect Immun 72:5807-13. 2004
    ..These results demonstrate that antibody is not required for clearance of pneumococcal colonization in mice...
  25. pmc Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1
    Florian Hladik
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Immunity 26:257-70. 2007
    ..Our findings shed light on the very earliest steps of mucosal HIV infection in vivo and may guide the design of effective strategies to block local transmission and prevent HIV-1 spread...
  26. ncbi Human defensins and LL-37 in mucosal immunity
    Mona Doss
    Boston University School of Medicine, Department of Medicine, Boston, Massachusetts, USA
    J Leukoc Biol 87:79-92. 2010
    ..g., Crohn's disease, atopic dermatitis, lung or urinary infections). Challenges for these studies are the redundancy of innate defense mechanisms and the presence and interactions of many innate defense proteins in mucosal secretions...
  27. pmc Repeated vaginal administration of trimeric HIV-1 clade C gp140 induces serum and mucosal antibody responses
    M P Cranage
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s University of London, London, UK
    Mucosal Immunol 3:57-68. 2010
    ..Our data prove the concept that repeated exposure of the female genital tract to HIV envelope can induce mucosally detectable antibody...
  28. ncbi Oral exposure to diabetes-promoting food or immunomodulators in neonates alters gut cytokines and diabetes
    Fraser W Scott
    Molecular Medicine Program, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Diabetes 51:73-8. 2002
    ..Thus, oral exposure to diabetes-promoting food antigens and immune modulators in neonates can modify diabetes expression in association with changes in local cytokine balance in the gut...
  29. pmc Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers
    P ng Loke
    Department of Medical Parasitology, New York University Langone Medical Center, New York, NY
    Blood 115:e20-32. 2010
    ..In addition to providing an approach that integrates flow cytometry datasets with transcriptional profiling analysis, these results underscore the importance of the sustained inflammatory response that attends progressive HIV disease...
  30. ncbi Mucosal immunity and vaccines
    Jan Holmgren
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute, Goteborg University, SE 405 30 Goteborg, Sweden
    Nat Med 11:S45-53. 2005
    ..Here we review the properties of the mucosal immune system and discuss advances in the development of mucosal vaccines for protection against infections and for treatment of various inflammatory disorders...
  31. ncbi Single mucosal immunization of recombinant adenovirus-based vaccine expressing F1 protein fragment induces protective mucosal immunity against respiratory syncytial virus infection
    Sol Kim
    Division of Life and Pharmaceutical Sciences, and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, 11 1 Dae Hyun Dong, Seo Dae Mun Gu, Seoul 120 750, Republic of Korea
    Vaccine 28:3801-8. 2010
    ..Taken together, our data demonstrate that a single intranasal administration of rAd/F1co is sufficient for the protection and represents a promising prophylactic vaccination regimen against RSV infection...
  32. ncbi Innate and adaptive immunity in female genital tract: cellular responses and interactions
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunol Rev 206:306-35. 2005
    ..By understanding the nature of this protection and the ways in which innate and adaptive immunity interact, these studies provide the opportunity to contribute to the foundation of information essential for ensuring reproductive health...
  33. ncbi Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Immunol Rev 206:32-63. 2005
    ....
  34. ncbi Generation of gut-homing T cells and their localization to the small intestinal mucosa
    Bengt Johansson-Lindbom
    Immunology Section, Lund University, Lund, Sweden
    Immunol Rev 215:226-42. 2007
    ..Instead, functionally specialized CD103(+) DCs derived from the small intestinal LP appear to selectively regulate T-cell homing to the small intestine...
  35. ncbi Effects of human fecal flora on intestinal morphology and mucosal immunity in human flora-associated piglet
    C Che
    Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, China
    Scand J Immunol 69:223-33. 2009
    ..to examine the effects of gut microbes from a different donor species on the intestinal morphology and mucosal immunity. Newborn germ-free piglets, obtained by caesarean section, were orally inoculated with a human and a porcine ..
  36. pmc The biology of intestinal immunoglobulin A responses
    Andrea Cerutti
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, and Weill Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Immunity 28:740-50. 2008
    ..Here we discuss the role of intestinal IgA in host-commensal mutualism, immune protection, and tolerance and summarize recent advances on the role of innate immune cells in intestinal IgA production...
  37. ncbi Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity
    Gabriel Vinderola
    Centro de Referencia para Lactobacilos CERELA CONICET, Tucuman, Argentina
    Cytokine 36:254-60. 2006
    ....
  38. pmc Correlation of vaccine-elicited systemic and mucosal nonneutralizing antibody activities with reduced acute viremia following intrarectal simian immunodeficiency virus SIVmac251 challenge of rhesus macaques
    Rachmat Hidajat
    Vaccine Branch, National Cancer Institute, Bethesda, Maryland 20892 5065, USA
    J Virol 83:791-801. 2009
    ..The pattern of elevated immune responses in the I/O group is consistent with its better control of acute viremia mediated, at least in part, by ADCVI activity and transcytosis inhibition...
  39. ncbi The pneumococcus: carriage, disease and conjugate vaccines
    Steven Obaro
    Department of Paediatrics, Imperial College School of Medicine, St Mary s Hospital, London UK
    J Med Microbiol 51:98-104. 2002
    ..However, in view of the multiplicity of serotypes and the biology of the pneumococcus, optimism must be tempered by caution...
  40. ncbi Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity
    A Bonner
    Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London, UK
    Mucosal Immunol 2:74-84. 2009
    ..immunoglobulin A (SIgA) is the most prevalent antibody in the human body and a first line of defense in mucosal immunity. We located secretory component (SC) relative to dimeric IgA1 (dIgA1) within the SIgA1 structure using the ..
  41. pmc Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats
    F Barreau
    Neurogastroenterology and Nutrition Unit, Institut National de la Recherche Agronomique, Toulouse, France
    Gut 53:501-6. 2004
    ..The present study aimed to establish whether maternal deprivation affects colonic epithelial barrier and the development of an experimental colitis in adult rats...
  42. ncbi Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage
    Andrew T Vaughan
    Department of Cellular and Molecular Medicine, School of Medical Science, University of Bristol, Bristol, United Kingdom
    J Immunol 182:2231-40. 2009
    ..lactamica maintains a commensal relationship with the host in the absence of an adaptive immune response. This may prolong the period of susceptibility to colonization by both pathogenic and nonpathogenic Neisseria species...
  43. ncbi Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, and Department of Medicine, Rochester General Hospital, Rochester, New York, USA
    J Infect Dis 190:373-8. 2004
    ..Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection...
  44. pmc Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
    Manuela Raffatellu
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California 95616 8645, USA
    Nat Med 14:421-8. 2008
    ..We conclude that SIV infection impairs the IL-17 axis, an arm of the mucosal immune response preventing systemic microbial dissemination from the gastrointestinal tract...
  45. ncbi Modulating dendritic cells to optimize mucosal immunization protocols
    E Williamson
    Department of Molecular Immunology, Immunex Corporation, Seattle WA 98101, USA
    J Immunol 163:3668-75. 1999
    ..Flt3L may therefore be a reagent useful for the design of mucosal immunization strategies...
  46. ncbi Mucosal immunity in asthma and chronic obstructive pulmonary disease: a role for immunoglobulin A?
    Charles Pilette
    Unit of Microbiology, University of Louvain, 54 Avenue Hippocrate BP5490, B 1200 Brussels, Belgium
    Proc Am Thorac Soc 1:125-35. 2004
    ..Future studies will hopefully yield better knowledge of IgA biology and lung mucosal immunity and help to use more efficiently the mucosal route for immunotherapy or target specific genes in inflamed ..
  47. ncbi Oral mucosal immunity and HIV/SIV infection
    F X Lu
    California National Primate Research Center and Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA
    J Dent Res 86:216-26. 2007
    ....
  48. ncbi Immunologic uniqueness of the genital tract: challenge for vaccine development
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Box 1, 845 19th Street South, Birmingham, AL 35294, USA
    Am J Reprod Immunol 53:208-14. 2005
    ..Furthermore, combined systemic and mucosal (oral, rectal, and especially intranasal) immunization may induce protective humoral responses in both the systemic and mucosal compartments of the immune system...
  49. ncbi Effects of early enteral nutrition supplemented with arginine on intestinal mucosal immunity in severely burned mice
    Jun Fan
    Department of Burns, The Northern Hospital, 83 Wenhua Road, Shenyang 110015, Liaoning, China
    Clin Nutr 29:124-30. 2010
    To investigate the effects of early enteral nutrition (EN) supplemented with Arginine (Arg) on intestinal mucosal immunity in severely burned mice.
  50. ncbi 3',5'-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection
    Hongbin Yan
    Department of Chemistry, Brock University, St Catharines, Ontario, Canada
    Biochem Biophys Res Commun 387:581-4. 2009
    ..These results, for the first time, provide direct evidence for the induction of protection against mucosal bacterial infections by cdiGMP as an adjuvant...
  51. pmc Th17 cytokines in mucosal immunity and inflammation
    Lokesh Guglani
    Division of Pulmonary Medicine, Allergy and Immunology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Curr Opin HIV AIDS 5:120-7. 2010
    ..Most importantly, it is becoming apparent that there is a fine balance between protective and pathological manifestation of Th17 responses at mucosal sites that defines immunity or inflammation...
  52. ncbi Pulmonary delivery of ISCOMATRIX influenza vaccine induces both systemic and mucosal immunity with antigen dose sparing
    J L K Wee
    Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Melbourne, Australia
    Mucosal Immunol 1:489-96. 2008
    ....
  53. ncbi Organogenic role of B lymphocytes in mucosal immunity
    T V Golovkina
    Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Science 286:1965-8. 1999
    ..The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers...
  54. ncbi PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity
    Marla J Keller
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    AIDS 21:467-76. 2007
    ..The objective of this study was to examine the effect of 14 daily applications of 0.5% PRO 2000 or placebo gel on mediators of mucosal immunity and intrinsic antimicrobial activity.
  55. ncbi Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity
    Gui bo Yang
    Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Neuroimmunol 146:46-9. 2004
    ..These results provide morphological evidence to suggest interactions between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa. This further supports a possible role of 5-HT in mucosal immune responses...
  56. ncbi M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis
    Sinead C Corr
    Department of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    FEMS Immunol Med Microbiol 52:2-12. 2008
    ..In this review, the origin and morphology of M-cells, and their role in mucosal immunity and pathogenesis of infections are discussed.
  57. ncbi Induction of mucosal immunity by inactivated poliovirus vaccine is dependent on previous mucosal contact with live virus
    T M Herremans
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    J Immunol 162:5011-8. 1999
    ..It is concluded that IPV vaccination alone is insufficient to induce a mucosal IgA response against poliovirus. In mucosally (OPV-) primed individuals, however, booster vaccination with IPV leads to a strong mucosal IgA response...
  58. ncbi An African perspective on mucosal immunity and HIV-1
    P Pala
    Medical Research Council Uganda Virus Research Institute, Entebbe, Uganda
    Mucosal Immunol 2:300-14. 2009
    HIV prevention mandates an understanding of the mechanisms of mucosal immunity with attention to some unique features of the epidemic and mucosal environment in the developing world...
  59. pmc Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profile
    A M Fahrer
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 98:10261-6. 2001
    ..This study provides a strong basis for further investigations of the roles of these cells as well as mucosal immune defense in general...
  60. ncbi Mucosal immunity after vaccination with monovalent and trivalent oral poliovirus vaccine in India
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
    J Infect Dis 200:794-801. 2009
    Persistent wild-poliovirus transmission, particularly in India, has raised questions about the degree of mucosal immunity induced by oral poliovirus vaccine (OPV) in tropical countries.
  61. ncbi Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases
    Helena Tlaskalova-Hogenova
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Immunol Lett 93:97-108. 2004
    ..g. invading pathogens). This important requirement is fulfilled by several mechanisms of mucosal immunity: strongly developed innate defense mechanisms ensuring appropriate function of the mucosal barrier, existence ..
  62. pmc A foreign protein incorporated on the Tip of T3 pili in Lactococcus lactis elicits systemic and mucosal immunity
    Bernard R Quigley
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Infect Immun 78:1294-303. 2010
    ....
  63. ncbi Mucosal immunity: integration between mother and the breast-fed infant
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Vaccine 21:3382-8. 2003
    ..A beneficial clinical effect is also apparent in the industrialized world, even in relation to relatively common diseases such as otitis media and acute lower respiratory tract infections...
  64. ncbi Nasal DNA-MVA SIV vaccination provides more significant protection from progression to AIDS than a similar intramuscular vaccination
    M Manrique
    Department of Medicine, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts, USA
    Mucosal Immunol 2:536-50. 2009
    ....
  65. pmc Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells
    Tim Worbs
    Institute of Immunology, Department of Visceral and Transplantation Surgery, Hannover Medical School, 30625 Hannover, Germany
    J Exp Med 203:519-27. 2006
    ....
  66. ncbi Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
    C L Wilson
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 286:113-7. 1999
    ..Thus, matrilysin functions in intestinal mucosal defense by regulating the activity of defensins, which may be a common role for this metalloproteinase in its numerous epithelial sites of expression...
  67. ncbi Impaired mucosal immunity in L-selectin-deficient mice orally immunized with a Salmonella vaccine vector
    D W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 167:407-15. 2001
    ..This evidence shows that L-Sel is important for development of mucosal immunity, and absence of L-Sel is protective against salmonellosis.
  68. pmc T-cell activation occurs simultaneously in local and peripheral lymphoid tissue following oral administration of a range of doses of immunogenic or tolerogenic antigen although tolerized T cells display a defect in cell division
    Karen M Smith
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, UK
    Immunology 106:144-58. 2002
    ..However, the presence of an adjuvant enhances clonal expansion in the MLN while tolerized T cells display defective cell division...
  69. ncbi Mucosal immunity induced by adenovirus-based H5N1 HPAI vaccine confers protection against a lethal H5N2 avian influenza virus challenge
    Ki Seok Park
    Laboratory of Cellular Immunology, Division of Molecular and Life Sciences, POSTECH, Pohang 790 784, Republic of Korea
    Virology 395:182-9. 2009
    ..These findings suggest that the strategies used to induce multi-antigen-targeted mucosal immunity, such as IN/IM delivery of rAdv-AI, may be a promising approach for developing broad protective vaccines that ..
  70. ncbi Recent advances in mucosal vaccines and adjuvants
    Kristina Eriksson
    Department of Medical Microbiology and Immunology and Göteborg University Vaccine Research Institute GUVAX, Goteborg University, Guldhedsgatan 10A, 413 46 Goteborg, Sweden
    Curr Opin Immunol 14:666-72. 2002
    ..However, there have also been failures, such as the withdrawal of an oral vaccine against rotavirus diarrhea and a nasal vaccine against influenza, because of their potential side effects...
  71. ncbi Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen
    Prosper N Boyaka
    Department of Microbiology and Oral Biology, Immunobiology Vaccine Center, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 170:5636-43. 2003
    ..parenterally, such as the aluminum-adsorbed anthrax vaccine, will most likely not induce the needed mucosal immunity to efficiently protect the initial site of infection with inhaled anthrax spores...
  72. pmc Anatomical route of invasion and protective mucosal immunity in Trypanosoma cruzi conjunctival infection
    O K Giddings
    Department of Molecular Microbiology and Immunology, St Louis University Health Science Center, 3635 Vista Ave, FDT 8N, St Louis, MO 63110, USA
    Infect Immun 74:5549-60. 2006
    ..Preceding mucosal infection induces mucosal immunity, resulting in at least 50-fold reductions in recoverable tissue parasite DNA in immune mice compared to ..
  73. ncbi Cytokines as adjuvants for the induction of mucosal immunity
    P N Boyaka
    The Department of Microbiology and The Immunobiology Vaccine Center, The University of Alabama at Birmingham, Bevill Biomedical Research Building, Room 761, 845 19th Street South, Birmingham, AL 35294-2170, USA
    Adv Drug Deliv Rev 51:71-9. 2001
    ..Interleukin-12, IL-1, and the chemokines Lptn and RANTES promote mucosal immunity. In contrast, nasal IL-6 and defensins failed to induce mucosal S-IgA Ab responses, suggesting that ..
  74. ncbi Role of NKT cells in the digestive system. IV. The role of canonical natural killer T cells in mucosal immunity and inflammation
    Gerhard Wingender
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1-8. 2008
    ..In this review, we will focus on the role of both of these canonical NKT cell populations in the mucosal tissues of the intestine...
  75. ncbi Intranasal immunization with SIV virus-like particles (VLPs) elicits systemic and mucosal immunity
    Qizhi Yao
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Vaccine 20:2537-45. 2002
    ..These results suggest that VLPs are effective mucosal antigens that can induce both humoral and cellular immune responses at systemic and mucosal sites...
  76. ncbi The immune geography of IgA induction and function
    A J MacPherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Mucosal Immunol 1:11-22. 2008
    ..The discovery of IgA and the realization that it dominates humoral mucosal immunity, in contrast to the IgG dominance of the systemic immune system, was early evidence for the distinct nature ..
  77. ncbi Nasal Flt3 ligand cDNA elicits CD11c+CD8+ dendritic cells for enhanced mucosal immunity
    Kosuke Kataoka
    Department of Oral Biology, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 172:3612-9. 2004
    ..In this study, we assessed a cDNA vector for Flt3 ligand (FL) for its potential to enhance mucosal immunity or tolerance...
  78. pmc Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome
    Jeroen Aerssens
    Johnson and Johnson Pharmaceutical Research and Development, Division of Janssen Pharmaceutica N V, Beerse, Belgium
    Clin Gastroenterol Hepatol 6:194-205. 2008
    ..We used microarray expression profiling of sigmoid colon mucosa to assess whether there are stably expressed sets of genes that suggest there are objective molecular biomarkers associated with IBS...
  79. ncbi Assessment of mucosal immunity to HIV-1
    Vicky Jespers
    HIV STI Epidemiology and Control Unit, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerpen, Belgium
    Expert Rev Vaccines 9:381-94. 2010
    ....
  80. ncbi Immune-mediated alteration in gut physiology and its role in host defence in nematode infection
    W I Khan
    Intestinal Disease Research Program, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Parasite Immunol 26:319-26. 2004
    ....
  81. ncbi Monoclonal IgA antibody-mediated expulsion of Trichinella from the intestine of mice
    T Inaba
    Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Parasitology 126:591-8. 2003
    ..It is concluded that the mucosal IgA response, when adequately induced, can impede the establishment of infective Trichinella parasites in the mouse intestine...
  82. ncbi Contributions of mucosal immune cells to methotrexate-induced mucositis
    Barbara A E de Koning
    Division of Pediatric Oncology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, PO Box 2060, 3000 GE Rotterdam, The Netherlands
    Int Immunol 18:941-9. 2006
    ..We conclude that mucosal immune responses remain resilient during MTX-induced mucositis. Whereas TNF-alpha production may contribute to mucosal damage, IL-10 may regulate by restricting excessive mucositis...
  83. pmc Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production
    Ashlesh K Murthy
    Department of Biology, University of Texas at San Antonio, 6900N Loop 1604W, San Antonio, TX 78249, USA
    Infect Immun 75:666-76. 2007
    ..Together, these results demonstrate that secreted chlamydial antigens may be novel vaccine candidates to induce protective immunity...
  84. ncbi Immunity, inflammation, and allergy in the gut
    Thomas T MacDonald
    Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Science 307:1920-5. 2005
    ..This suggests that perturbing homeostasis between gut antigens and host immunity represents a critical determinant in the development of gut inflammation and allergy...
  85. ncbi Normal structure, function, and histology of mucosa-associated lymphoid tissue
    Mark F Cesta
    Integrated Laboratory Systems Inc, 601 Keystone Park Drive, Durham, NC 27713, USA
    Toxicol Pathol 34:599-608. 2006
    ..MALT tissues comprise the mucosal immune system which can function independently of the systemic immune system and are, therefore, an important and often overlooked aspect of immunopathology...
  86. ncbi Mucosal immunity to influenza without IgA: an IgA knockout mouse model
    I N Mbawuike
    Departments of Microbiology, Influenza Research Center, Respiratory Pathogens Research Unit, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 162:2530-7. 1999
    ....
  87. ncbi Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, INSERM, U631, France
    Nat Rev Immunol 9:229-34. 2009
    ....
  88. ncbi In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
    S Fagarasan
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan
    Nature 413:639-43. 2001
    ..We conclude that IgA+ cells in the gut lamina propria are generated in situ from B220+IgM+ lymphocytes...
  89. ncbi Paneth cell defensins: endogenous peptide components of intestinal host defense
    A J Ouellette
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 10:1280-9. 1996
    ..Because cryptdins mediate innate immunity in the hostile environment of the intestinal lumen, it should be of interest to define biochemical and biophysical attributes that adapt these peptides to barrier function of mucosal surfaces...
  90. ncbi Mucosal immunity and tolerance in the elderly
    Kohtaro Fujihashi
    Immunobiology Vaccine Center, Departments of Oral Biology and Microbiology, The University of Alabama at Birmingham, 845 19th Street South, Bevill Biomedical Res Bldg Rm 761, Birmingham, AL 35294, USA
    Mech Ageing Dev 125:889-98. 2004
    ..Indeed, the frequencies of naive CD4+ T cells and dendritic cells (DCs) in Peyer's patches of aged mice were reduced and this led to a lack of essential cytokine synthesis for the induction of either S-IgA immunity or oral tolerance...
  91. pmc Systemic, mucosal, and heterotypic immune induction in mice inoculated with Venezuelan equine encephalitis replicons expressing Norwalk virus-like particles
    Patrick R Harrington
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7400, USA
    J Virol 76:730-42. 2002
    ..Expression of NLV VLPs in mammalian cells offers a powerful approach for the design of novel NLV vaccines, either alone or in combination with current vaccination models...
  92. ncbi Modulation of mucosal immunity in a murine model of food-induced intestinal inflammation
    C R Cardoso
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Exp Allergy 38:338-49. 2008
    ....
  93. ncbi Oral vaccination of mice against tetanus with recombinant Lactococcus lactis
    K Robinson
    Department of Pathology, University of Cambridge, UK
    Nat Biotechnol 15:653-7. 1997
    ..Chemically killed lactococci administered via the intranasal route were also able to elicit serum antibody responses of similar levels and kinetics to those induced by live bacteria...
  94. pmc GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice
    L Santucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Scienze Chirurgiche, Gastroenterologiche ed Epatologiche, Universita di Perugia, Policlinico Monteluce, 06122 Perugia, Italy
    Gut 56:52-60. 2007
    ..GITR triggering leads to activation of T effectors and reversal of suppressive function of regulatory T cells...
  95. ncbi Molecular adjuvants for mucosal immunity
    Felix N Toka
    Department of Microbiology, University of Tennessee, Walter s Life Sciences Building, Knoxville, TN 37996, USA
    Immunol Rev 199:100-12. 2004
    ..This review summarizes the progress in the use of genetic vaccines to achieve mucosal immunity and discusses the needed strategies to maximize long-term prospective immunity at this vulnerable entry site.
  96. ncbi Nasal-associated lymphoid tissue is a mucosal inductive site for virus-specific humoral and cellular immune responses
    Adrian W Zuercher
    Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 168:1796-803. 2002
    ..Together these data provide direct evidence that NALT is a mucosal inductive site for humoral and cellular immune responses in the upper respiratory tract...
  97. ncbi Regulated MIP-3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity
    A Izadpanah
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623, USA
    Am J Physiol Gastrointest Liver Physiol 280:G710-9. 2001
    ..an array of chemokines known to signal the trafficking of neutrophils and monocytes important in innate mucosal immunity. We hypothesized that intestinal epithelium may also have the capacity to play a role in signaling host ..
  98. ncbi The effects of HIV infection on oral mucosal immunity
    S J Challacombe
    Department of Oral Medicine, Pathology and Immunology, Guys, Kings and St Thomas Dental Institute, King s College London, Floor 28, Guys Tower, Guys Hospital, London SE1 9RT, UK
    Adv Dent Res 19:29-35. 2006
    Oral mucosal infections, especially candidiasis, are a feature of HIV disease, suggesting that compromised mucosal immunity within the oral cavity is a consequence of the viral infection...
  99. ncbi Mucosal immunity: its role in defense and allergy
    Helena Tlaskalova-Hogenova
    Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Science of the Czech Republic, Prague, Czech Republic
    Int Arch Allergy Immunol 128:77-89. 2002
    ..e. by induction of mucosal (oral) tolerance. Characteristic features of mucosal immunity distinguishing it from systemic immunity are: strongly developed mechanisms of innate defense, the existence ..
  100. ncbi The anatomy of mucosal immune responses
    Paul Garside
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, G11 6NT, United Kingdom
    Ann N Y Acad Sci 1029:9-15. 2004
    ..Thus, both gross and fine anatomical location of fed antigen presentation may be important in mucosal immunoregulation...
  101. ncbi Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis
    Colby Zaph
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 446:552-6. 2007
    ..These results indicate that the balance of IKK-beta-dependent gene expression in the intestinal epithelium is crucial in intestinal immune homeostasis by promoting mucosal immunity and limiting chronic inflammation.

Research Grants75

  1. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..Because virtually all of the limited information available concerning the determinants of protective mucosal immunity comes from studies in adults, we will also focus some efforts in exploring the responses to oral immunization ..
  2. Development of Vaccines against Clostridium difficile Infection
    SAUL R TZIPORI; Fiscal Year: 2013
    ..proposal is to design a vaccine that targets both TcdA and TcdB, with a view to elicit strong systemic and mucosal immunity to prevent CDI, reduce the severity, or eliminate an ongoing chronic disease...
  3. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ..VLP is hypothesized to have strong specificity in targeting mucosal region, leading to potent induction of mucosal immunity. In collaboration with Dr Kit Lam and Dr Christopher Walker, two experts respectively in drug discovery and ..
  4. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..friendly" commensal bacteria, as an environmental factor, can protect against diabetes development through mucosal immunity initiated by dendritic cells (DCs)...
  5. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ..A subset of T cells, designated memory T cells, are important targets for enhancing mucosal immunity because they are the predominant T cell subset that migrates to and resides in mucosal sites such as the lung ..
  6. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..to infants in anatomy, gastrointestinal physiology, nutrient requirements/metabolism, and development of mucosal immunity. Also swine metabolize retinol comparable to humans...
  7. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ..We believe that a possible additional candidate affecting mucosal immunity in health and disease is FPR...
  8. Mucosal Immunity and Influenza Vaccines: Phenotype and Role of Activated B Cells
    HARRY BERNARD GREENBERG; Fiscal Year: 2010
    ..Although B cell responses are considered a critical component of the influenza mucosal immunity, traditional analyses of B cell immunity after influenza vaccination have been largely limited to studies of ..
  9. Mucosal Immunity and Microbiota in Intestinal Graft-versus-Host Disease
    Marcel R m van den Brink; Fiscal Year: 2013
    ..Therefore, we expect that these preclinical studies have a high likelihood to improve prophylaxis and treatment of intestinal GVHD as well as overall outcome in allo BMT patients. ..
  10. Lung and bone marrow crosstalk during a respiratory infection
    CAROLINA B LOPEZ; Fiscal Year: 2010
    ..of crosstalk between these two compartments could create novel modes of intervention for the modulation of mucosal immunity during therapy and vaccination...
  11. Targeting the oral cavity epithelium for inducing mucosal immunity against HIV
    Harvinder Singh Gill; Fiscal Year: 2012
    ..DCs are potent antigen presenting cells that can help induce strong mucosal immunity by processing the antigen and presenting it to T-cells resident in the lymphoid tissues...
  12. Role of innate immune responses in the activity of an Alphavirus based adjuvant.
    Robert E Johnston; Fiscal Year: 2013
    ..The robust induction of mucosal immunity by parenteral immunization is a novel and valuable feature of this adjuvant, and is superior to that achieved ..
  13. Gut microflora: Impact on neonatal immunity, viral gastroenteritis and vaccines
    ANASTASIA NICKOLAEVNA VLASOVA; Fiscal Year: 2013
    ..Gn pigs resemble infants in size, anatomy, physiology, development of mucosal immunity and are the only animal model susceptible to HRV diarrhea...
  14. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda J Saif; Fiscal Year: 2010
    ..and work with specialized animal disease models (Gn pigs) as well as to enhance analytical skills related to mucosal immunity. Thus the INTA team will receive reagents and training related to the study of mucosal immune responses in Gn ..
  15. Mechanisms of flagellin-induced protection against microbial keratitis
    Fu Shin X Yu; Fiscal Year: 2013
    ..The hypothesis in this application is that flagellin, through TLR5, stimulates protective corneal innate mucosal immunity that involves epithelial cells, infiltrated PMNs, and activated dendritic cells, collectively conferring ..
  16. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..This gap in our knowledge makes the proposed studies an exciting new frontier with broad relevance for mucosal immunity in humans...
  17. IL-15 Characterization Through Experimental Immunology
    Michael A Caligiuri; Fiscal Year: 2013
    ..useful for modulating the immune system in treating acute myeloid leukemia, for providing new insights into mucosal immunity that will likely be important for oral vaccine development, and for establishing new preclinical data ..
  18. Protecutive immunity to human cholera in Bangladesh
    Edward T Ryan; Fiscal Year: 2013
    ..cholerae infection thus serves as an excellent model for the study of mucosal immunity and vaccination...
  19. Mucosal innate immune defense to Rift Valley fever virus
    Amy G Hise; Fiscal Year: 2010
    ..The mechanisms of aerosolized RVFV infection and mucosal immunity that are critical for protective immunity are poorly understood...
  20. Impact of aryl hydrocarbon receptor ligand ingestion on gastrointestinal immunity
    Barbara Platzer; Fiscal Year: 2013
    ..of AhR in dendritic cells and intestinal epithelial cells, two key cell types for the regulation of mucosal immunity. We will compare AhR activation induced by AhR ligands of two distinct ligand classes relevant for human ..
  21. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mucosal Immunity includes many molecular entities, many of which remain poorly understood...
  22. Specific Contribution of a New IG Isotype (IGT) in Teleost Fish Immune Responses
    J Oriol Sunyer; Fiscal Year: 2013
    ..The overarching goal of this proposal is to use our fish-parasite model to gain primordial insights of mucosal immunity that will facilitate the analysis of existing paradigms in human mucosal immunology...
  23. Viral Gastroenteritis: Basis of Protection and Virulence
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    ..They also represent a highly tractable system to study basic aspects of innate, acquired and mucosal immunity and viral pathogenesis, all important issues for the future of infectious disease prevention and treatment.
  24. 15-lipoxygenase regulation of mucosal immunity in allergic airways disease
    Douglas A Kuperman; Fiscal Year: 2011
    ..There is strong evidence that suppression of SIgA produces a failure of mucosal immunity in allergic disease...
  25. Regulation of vitamin A metabolism during Schistosoma mansoni infection
    PNG LOKE; Fiscal Year: 2013
    ..Recently, vitamin A metabolism and retinoic acid (RA) has emerged to be important in regulating mucosal immunity. Aldh1a2 is the major enzyme regulating RA production by antigen presenting cells in the gut...
  26. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne A Marasco; Fiscal Year: 2010
    ..Project represents the combined efforts of the Marasco (Antibody Engineering, Gene Therapy), Anderson (Mucosal Immunity) and Mansfield (HIV/AIDS Macaque Model) laboratories to investigate whether stable adeno-associated virus (..
  27. Immune Responses in Otitis Prone Children
    Michael E Pichichero; Fiscal Year: 2013
    ..to (1) identify specific adaptive immune deficits in OP children;(2) determine independent contributions of mucosal immunity in OP children;(3) understand the role of innate responses to co-infection of respiratory bacteria and ..
  28. Intestinal Antigen Presenting Cells and Mucosal Immunity
    Timothy L Denning; Fiscal Year: 2013
    ..The outcome of these studies will have potential therapeutic value for treating human IBD. ..
  29. Retrotranslocation of cholera toxin AI-chain from ER ot cytosol and cell response
    Jin Ah Cho; Fiscal Year: 2010
    ..CT is a prominent bacterial factor that signals the host in regulating intestinal physiology and adaptive mucosal immunity, we want to know how signal transduction by CT in the inflammatory response is explained...
  30. POLLEN GRAINS AS TROJAN HORSES FOR ORAL VACCINATION
    Harvinder Singh Gill; Fiscal Year: 2012
    ..b>Mucosal immunity is a powerful host-regulated defense at the mucosal surfaces that can neutralize pathogens while they are ..
  31. Synthetic Gypsogenin Saponins as Synergistic Vaccine Adjuvants
    ASHISH KUMAR PATHAK; Fiscal Year: 2013
    ..The outcome of this proposal can also facilitate the development of saponin analogs that can stimulate mucosal immunity for potential improvement in nasal delivery of vaccines.
  32. Novel Cytokine Regulation of Gut Function and Inflammation
    Aiping Zhao; Fiscal Year: 2013
    ..of IL-25 and also express IL-25 receptors IL-17RA and IL-17RB implicating this cytokine as a key component in mucosal immunity. The central hypothesis of this project is that epithelial derived IL-25 plays a key role in modulating ..
  33. Alternative approaches for NALT-based immunity to respiratory pathogens
    Prosper N Boyaka; Fiscal Year: 2013
    ..in specific aim three will identify inductive sites for the generation of secretory IgA (SIgA) Abs and mucosal immunity after sublingual immunization with EdTx-derivatives...
  34. Novel Mucosa-homing Dendritic Cell: Development, Trafficking and Function
    Eugene C Butcher; Fiscal Year: 2013
    ..d) ?DC may have specialized roles in mucosal immunity as evidenced by unique TLR responses and effector activities...
  35. Cervical Maturity, Mucosal Immunity, and Chlamydia trachomatis infection
    Loris Y Hwang; Fiscal Year: 2012
    ..the following goals: 1) to conduct clinical translational research on cervical epithelial maturity, mucosal immunity, and Chlamydia trachomatis infection in adolescents;2) to gain knowledge of basic and mucosal immunology;3) ..
  36. Intestinal Lymphocyte Trafficking
    Eugene C Butcher; Fiscal Year: 2013
    ..bowel diseases, as well as providing insights that can improve methods of vaccination and monitoring of mucosal immunity to intestinal pathogens, and to HIV...
  37. Th17 Cytokines and Lung Immunity
    Jay K Kolls; Fiscal Year: 2013
    ..and these cytokines regulate both G-CSF and antimicrobial proteins in lung epithelial cells to achieve mucosal immunity in the lung. We will test this hypothesis with the following Specific Aims: Specific Aim 1...
  38. Recombinant Attenuated Bacterial Vaccines Against Biodefense Agents
    Roy Curtiss; Fiscal Year: 2013
    ..and delivery of engineered ligands to various innate immunity external and internal receptors and stimulate mucosal immunity in all secretory glands and on all mucosal surfaces...
  39. FASEB Summer Research Conference titled "THE LUNG EPITHELIUM IN HEALTH AND DISEAS
    MICHAEL FRANCIS BEERS; Fiscal Year: 2010
    ..mesenchymal transition, and their involvement in lung repair and disease;(8) The role of innate and mucosal immunity in regulating inflammatory homeostasis within the airways and alveoli...
  40. Novel Vaccines To Evoke Bladder Mucosal Immunity
    David J Klumpp; Fiscal Year: 2010
    ..This project will characterize immune responses to a novel class of vaccines to treat urinary tract infection. ..
  41. GINGIVA DERIVED MSCS: ROLE IN IMMUNOMODULATION AND TISSUE REGENERATION
    Yufang Shi; Fiscal Year: 2013
    ..a unique oral tissue that functions both as a biological mucosal barrier and a component of the oral mucosal immunity. Interestingly, hGMSCs exhibit not only multipotent differentiation and self-renewal capacities but also ..
  42. Quantification of Immune Cells in Women Using Contraception
    SHARON LYNELLE ACHILLES; Fiscal Year: 2013
    ..is established that progesterone and progestin have effects on the human immune system, including effects on mucosal immunity. Genital tract immune cells are common portals of entry for HIV yet little is known about the effects of ..
  43. Regulation and Function of Immunoglobulin D in Mucosal Immune Defense
    Andrea Cerutti; Fiscal Year: 2013
    ..controlled by vitamin D3 and that IgD produced reacts against respiratory pathogens and contributes to mucosal immunity by activating local and systemic innate immune cells such as basophils and mast cells through interaction ..
  44. Oral Mucosa Barrier and Bisphosphonate-related Osteonecrosis of the Jaw
    Ichiro Nishimura; Fiscal Year: 2013
    ..Therefore, we postulate that BP treatment may abnormally activate the mucosal immunity of oral barrier tissue resulting in generating a cytotoxic environment leading to osteonecrosis...
  45. Identification of Antigens for Anti-HIV Broadly Neutralizing Responses
    Steven L Zeichner; Fiscal Year: 2013
    ..Immunogens found to induce a BN anti-HIV immune response in this screen would be good candidates for further development into an HIV vaccine that induced mucosal immunity.
  46. Determining the role of human endogenous retroviruses (HERV) in HIV-1 infection
    Devi SenGupta; Fiscal Year: 2013
    ..Mike" McCune, Chief of the Division of Experimental Medicine at UCSF, who conducts research in Tregs and mucosal immunity, and Dr. Steven G...
  47. Immunomodulatory effects of intestinal helminthes on mucosal immunity
    Hai Ning Shi; Fiscal Year: 2013
    ..inflammation emphasize the need for a better understanding of the mechanisms by which helminths modulate host mucosal immunity. Our observations of deleterious consequences of helminth parasites in both bacterial and T cell mediated ..
  48. Safety of Non-Medicated Intravaginal Rings for Microbicide Delivery
    Marla J Keller; Fiscal Year: 2010
    ..Changes in prevalent lactobacilli or other bacteria following prolonged ring use may modify genital tract mucosal immunity and enhance susceptibility to HIV...
  49. Three-dimensional Scaffold-based Systems for Primary Human Intestinal Culture
    Calvin J Kuo; Fiscal Year: 2013
    ..The potential for modeling mucosal immunity (innate versus cellular/humoral) and inflammatory bowel diseases in primary human culture is present, as well ..
  50. MOLECULAR AND CELLULAR TRANSPORT IN MUCUS
    W Mark Saltzman; Fiscal Year: 2012
    ..to sperm antigens in the mouse;orally-administered polymer microparticles loaded with Vg can stimulate mucosal immunity in the vagina;surface modification of particles can influence local transport and antigen processing in ..
  51. New Vaccine against Influenza
    Mingtao Zeng; Fiscal Year: 2011
    ..a noninvasive nasal mucosal route which is convenient for administration and maybe more efficient to elicit mucosal immunity for protection against a possible pandemic influenza...
  52. Elucidation of the transcriptional network underlying the Th17 lineage program
    Dan Littman; Fiscal Year: 2013
    ..We anticipate that the proposed studies will help identify new targets for therapeutic modulation of Th17 cells in humans to either boost mucosal immunity or attenuate inflammation.
  53. Genetic control over the gut microbiome composition
    Daniel Pomp; Fiscal Year: 2010
    ..environmental factors (chance exposure, diet) and a number of host genetic factors such as those influencing mucosal immunity. Similarly, those host genetic loci that affect composition of the gut microbiome, especially those portions ..
  54. High-throughput proteomic study of protective immunity in human cholera infection
    Richelle C Charles; Fiscal Year: 2013
    ..cholerae immune response, using the antibody-in lymphocyte (ALS ) assay, a marker of mucosal immunity, and (3) characterize anti-V. cholerae memory B cell responses during human wild-type V...
  55. Visualizing impacts of T. gondii invasion events on mucosal immunity
    DAVID ALLAN CHRISTIAN; Fiscal Year: 2012
    ..The overall goal of this proposal is to elucidate the mechanisms by which Toxoplasma suppresses the immune system to prevent host resistance. ..
  56. Recognition of microbes by NKT cells at the lung mucosal surface
    Dale T Umetsu; Fiscal Year: 2010
    ..These results will provide a much greater appreciation and understanding of mucosal immunity to microorganisms present in the respiratory tract, and how these immune responses lead to respiratory ..
  57. Airway Metalloproteinases in Mucosal Immunity
    CAROLE LYNN WILSON; Fiscal Year: 2010
    ..These studies will provide important insight into the role of matrilysin in mucosal defense mechanisms. ..
  58. Somatic Diversification of Immunoglobulin Genes in GALT
    Katherine L Knight; Fiscal Year: 2013
    ..by applicant): The intestinal commensal microbiota is required for development of lymphoid tissues and mucosal immunity in vertebrates. However, little is known of the mechanism by which these processes occur...
  59. Microbiomes and Inflammation in Chronic Fatigue Syndrome
    RUTH EMILY LEY; Fiscal Year: 2013
    ..system could be responsible for some CFS symptoms and contribute to chronic immune activation by affecting mucosal immunity and by disrupting intestinal integrity, thus allowing translocation of bacteria into blood from the gut...
  60. IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLS
    Charles L Sentman; Fiscal Year: 2013
    ..induction of immunity, immunity against viruses, tumor immunity and immunotherapy, inflammation, vaccines, mucosal immunity, regulation of immunity, and autoimmunity...
  61. The Role of Inflammasomes in Mucosal Immunity to Intestinal Bacterial Pathogens
    Gabriel Nunez; Fiscal Year: 2013
    ..coli, two enteric bacterial pathogens. These studies may lead to better understanding of mechanisms that control host defense against human pathogens and the pathogenesis of inflammatory disease in the intestine. ..
  62. Mucosal Immune and Bacterial Characterization in Chronic Laryngitis
    Susan L Thibeault; Fiscal Year: 2013
    ..b>Mucosal immunity is determined by the interaction between the `immunological triad'of epithelial cells, bacteria, and ..
  63. MUCOSAL IMMUNITY TO HIV ENV BY ORAL VACCINATION
    Danuta Kozbor; Fiscal Year: 2001
    ..In these studies, we are seeking to define prime/boost strategies for the induction of high levels of mucosal immunity to HIV envelope (env) glycoprotein...
  64. Effects of Probiotic Lactobacilli on Rotavirus Immunity
    Lijuan Yuan; Fiscal Year: 2006
    ..The key questions that this study will address are: 1) Do commensal microbes enhance maturation of mucosal immunity by triggering toll-like receptors (TLR) and innate immune responses? and 2) Do they act synergistically with ..
  65. C. Perfringens to Induce Anti-HIV Mucosal Immunity
    Phalguni Gupta; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Antigenic exposure at intestinal mucosal surface induces mucosal immunity at local as well as at distant mucosal surfaces such as lung and genital surfaces...
  66. TEAR ABNORMALITIES IN NEUROLOGICAL DISEASES
    Patricia Coyle; Fiscal Year: 1990
    ..of tears in a prototype neuroimmune disorder (multiple sclerosis [MS]) which may involve abnormalities in mucosal immunity; and 2. how the nervous system may alter tear flow and composition in patients with neurolacrimal deficits. 1...
  67. Targeting Dendritic Cell Subsets in Human Vagina to Elicit Local Immunity
    SangKon Oh; Fiscal Year: 2010
    ..Therefore, vaccines that induce potent mucosal immunity in the vagina have a high potential for the prevention and treatment of STDs...
  68. RECOMBINANT PICORNAVIRUSES AS AIDS VACCINES
    Raul Andino; Fiscal Year: 2000
    ..requirements for protective immunization against HIV and other related lentiviruses involve 1) induction of mucosal immunity and 2) immunological responses against multiple viral antigens...
  69. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2009
    ..gingivalis as measured by alveolar bone loss and antibody responses. This work will lead to better understanding about how microflora can affect DCs. ..
  70. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne Marasco; Fiscal Year: 2009
    ..Project represents the combined efforts of the Marasco (Antibody Engineering, Gene Therapy), Anderson (Mucosal Immunity) and Mansfield (HIV/AIDS Macaque Model) laboratories to investigate whether stable adeno-associated virus (..
  71. Intestinal failure in children: A contemporary retrospective review by the Pediat
    Robert Squires; Fiscal Year: 2009
    ..associated with IF such as intestinal adaptation, PN related cholestasis, nutritional deficiencies, and mucosal immunity. In conjunction with the prospective registry, we will propose to identify, conduct, and complete ..
  72. Mucosal Immunity to Toxoplasma gondii
    L Sibley; Fiscal Year: 2007
    ..studies test the hypothesis that recruitment of inflammatory monocytes is responsible for induction of innate mucosal immunity and control of oral toxoplasmosis...
  73. C-Reactive Protein in Human Mucosal Immunity
    Jane Gould; Fiscal Year: 2005
    ..These results will be tested in vivo using murine models of respiratory tract infection with mice carrying the human CRP transgene. ..
  74. Novel vaccines for otitis media
    Elaine I Tuomanen; Fiscal Year: 2010
    ..underscores the importance of development of new vaccination strategies and a greater understanding of host mucosal immunity. To this end, intranasal vaccination has recently gained considerable attention as an alternative strategy ..
  75. MUCOSAL IMMUNITY OF THE GENITAL TRACT
    Peggy Crowley Nowick; Fiscal Year: 1999
    ..The goal of these studies is to l) evaluate the influence of ovarian steroid hormones on mucosal immunity in the genital tract; 2) establish a model of normal immune competence in cycling women; and 3) evaluate ..