macrophage activation

Summary

Summary: The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.

Top Publications

  1. pmc Exploring the full spectrum of macrophage activation
    David M Mosser
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Nat Rev Immunol 8:958-69. 2008
  2. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
  3. doi Alternative activation of macrophages: mechanism and functions
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Immunity 32:593-604. 2010
  4. ncbi Alternative activation of macrophages
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 3:23-35. 2003
  5. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
  6. pmc Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury
    Hideaki Nakajima
    Department of Orthopaedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Fukui, Japan
    J Neurotrauma 29:1614-25. 2012
  7. ncbi Macrophage activation and polarization
    Fernando Oneissi Martinez
    Istituto Clinico Humanitas, I 20089 Rozzano, Italy
    Front Biosci 13:453-61. 2008
  8. pmc Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    Carey N Lumeng
    Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
    Diabetes 57:3239-46. 2008
  9. pmc Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    Kihwa Kang
    Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Metab 7:485-95. 2008
  10. pmc Macrophage activation switching: an asset for the resolution of inflammation
    F Porcheray
    Laboratoire de Neuro Immuno Virologie, Service de Neurovirologie UMR E1, Universite Paris Sud, Centre de Recherches du Service de Sante des Armees, IPSC, Fontenay aux Roses, France
    Clin Exp Immunol 142:481-9. 2005

Detail Information

Publications403 found, 100 shown here

  1. pmc Exploring the full spectrum of macrophage activation
    David M Mosser
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Nat Rev Immunol 8:958-69. 2008
    ..We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations...
  2. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
    ..Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum...
  3. doi Alternative activation of macrophages: mechanism and functions
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Immunity 32:593-604. 2010
    The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease...
  4. ncbi Alternative activation of macrophages
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 3:23-35. 2003
    ..The concept of an alternative pathway of macrophage activation by the T(H)2-type cytokines interleukin-4 (IL-4) and IL-13 has gained credence in the past decade, to ..
  5. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
  6. pmc Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury
    Hideaki Nakajima
    Department of Orthopaedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Fukui, Japan
    J Neurotrauma 29:1614-25. 2012
    ..was designed to investigate the effects of MSC transplantation with a special focus on their effect on macrophage activation after SCI...
  7. ncbi Macrophage activation and polarization
    Fernando Oneissi Martinez
    Istituto Clinico Humanitas, I 20089 Rozzano, Italy
    Front Biosci 13:453-61. 2008
    ..Here we review the main functions of polarized macrophages and discuss the perspectives of this field...
  8. pmc Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    Carey N Lumeng
    Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
    Diabetes 57:3239-46. 2008
    ..To establish the mechanism of the phenotypic switch of adipose tissue macrophages (ATMs) from an alternatively activated (M2a) to a classically activated (M1) phenotype with obesity...
  9. pmc Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    Kihwa Kang
    Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Metab 7:485-95. 2008
    ..However, the mechanisms controlling tissue macrophage activation remain unclear...
  10. pmc Macrophage activation switching: an asset for the resolution of inflammation
    F Porcheray
    Laboratoire de Neuro Immuno Virologie, Service de Neurovirologie UMR E1, Universite Paris Sud, Centre de Recherches du Service de Sante des Armees, IPSC, Fontenay aux Roses, France
    Clin Exp Immunol 142:481-9. 2005
    ..In order to answer this question, we first characterized differential human macrophage activation phenotypes...
  11. doi Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    Subhra K Biswas
    Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
    Nat Immunol 11:889-96. 2010
    ..A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention...
  12. ncbi Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
    Laurent Monney
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:536-41. 2002
    ..Tim-3 may have an important role in the induction of autoimmune diseases by regulating macrophage activation and/or function.
  13. pmc The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria
    Mahesh Yadav
    Department of Biological Sciences, Center for Tropical Disease Research and Training, University of Notre Dame, 130 Galvin Life Science Center, Notre Dame, IN 46556, USA
    Blood 108:3168-75. 2006
    ..These are the first results to establish a significant role for dectin-1, in cooperation with TLR2, to activate a macrophage's proinflammatory response to a mycobacterial infection...
  14. ncbi Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology
    De Broski R Herbert
    University of Cape Town, Health Sciences Faculty, 7925 Cape Town, South Africa
    Immunity 20:623-35. 2004
    ..Together, this shows that alternative macrophages are essential during schistosomiasis for protection against organ injury through downregulation of egg-induced inflammation...
  15. doi Alternative activation of macrophages: an immunologic functional perspective
    Fernando O Martinez
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Annu Rev Immunol 27:451-83. 2009
    ..The classically known macrophage activation is induced by IFN-gamma, which triggers a harsh proinflammatory response that is required to kill ..
  16. pmc Control of macrophage activation and function by PPARs
    Ajay Chawla
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Circ Res 106:1559-69. 2010
    ..Because the dysregulation of macrophage activation is pathogenically linked to various metabolic, inflammatory and immune disorders, regulatory proteins ..
  17. ncbi Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
    Pascale Kropf
    Department of Immunology, Faculty of Medicine, Imperial College London, UK
    FASEB J 19:1000-2. 2005
    ..To address the underlying mechanisms, the arginase-induced L-arginine catabolism was investigated and the results demonstrate that arginase regulates parasite growth directly by affecting the polyamine synthesis in macrophages...
  18. pmc Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Nature 447:1116-20. 2007
    ..Disruption of PPARgamma in myeloid cells impairs alternative macrophage activation, and predisposes these animals to development of diet-induced obesity, insulin resistance, and glucose ..
  19. pmc Macrophage-mediated inflammation in metabolic disease
    Ajay Chawla
    Cardiovascular Research Institute, University of California San Francisco, California 94158 9001, USA
    Nat Rev Immunol 11:738-49. 2011
    ..In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease...
  20. pmc Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    Khoa D Nguyen
    Immunology Program, Stanford University, Palo Alto, California 94305, USA
    Nature 480:104-8. 2011
    ..we report in mice an unexpected requirement for the interleukin-4 (IL-4)-stimulated program of alternative macrophage activation in adaptive thermogenesis...
  21. pmc Macrophages: master regulators of inflammation and fibrosis
    Thomas A Wynn
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Liver Dis 30:245-57. 2010
    ..Although collagen-secreting myofibroblasts once were thought of as the master "producers" of fibrosis, this review will illustrate how macrophages function as the master "regulators" of fibrosis...
  22. pmc Alternatively activated macrophages in helminth infections
    Timothy Kreider
    Department of Medicine, UMDNJ New Jersey Medical School, MSB 639, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Opin Immunol 19:448-53. 2007
    ..In this review, we will discuss recent findings regarding the role of AAMPhis in the development of disease and host protection following helminth infection...
  23. doi Macrophage diversity and polarization in atherosclerosis: a question of balance
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy
    Arterioscler Thromb Vasc Biol 29:1419-23. 2009
    ..Thus, a "macrophage balance" plays a major role in the pathogenesis of atherosclerotic plaques and affects evolution and complications of atherosclerosis...
  24. ncbi Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
    R M Hoek
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    Science 290:1768-71. 2000
    ..Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage...
  25. pmc Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation
    Jian Liang
    Biomolecular Science Center, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
    PLoS ONE 3:e2880. 2008
    Previously, we have identified a novel CCCH zinc finger protein family as negative regulators of macrophage activation. To gain an overall insight into the entire CCCH zinc finger gene family and to evaluate their potential role in ..
  26. pmc TGFβ signaling plays a critical role in promoting alternative macrophage activation
    Dapeng Gong
    Division of Hematology Oncology, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
    BMC Immunol 13:31. 2012
    ..Whereas it is well-established that IL-4 can drive alternative activation, if lack of TGFβ signaling at physiological levels affects M2 polarization has not been addressed...
  27. ncbi Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    Wouter J de Jonge
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Nat Immunol 6:844-51. 2005
    Acetylcholine released by efferent vagus nerves inhibits macrophage activation. Here we show that the anti-inflammatory action of nicotinic receptor activation in peritoneal macrophages was associated with activation of the transcription ..
  28. doi Macrophage polarization in tumour progression
    Antonio Sica
    Department of Inflammation and Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 18:349-55. 2008
    ..Here, we discuss recent findings suggesting that targeting tumour-associated macrophages (TAMs) polarization may represent a novel therapeutic strategy against cancer...
  29. ncbi Annexin A2 is a soluble mediator of macrophage activation
    Jennifer F A Swisher
    Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Leukoc Biol 82:1174-84. 2007
    ....
  30. doi The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis
    Yuanyuan Wei
    Experimental Vascular Medicine, Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich, Pettenkoferstrasse 9, 80336 Munich, Germany
    Circulation 127:1609-19. 2013
    ..Because microRNAs (miRNAs) play a crucial role in cellular signaling by posttranscriptional regulation of gene expression, we studied the miRNA expression profiles during the progression of atherosclerosis...
  31. ncbi Immune control of tuberculosis by IFN-gamma-inducible LRG-47
    John D MacMicking
    Laboratory of Infection Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 302:654-9. 2003
    ..Thus, LRG-47 may serve as a critical vacuolar trafficking component used to dispose of intracellular pathogens like Mtb...
  32. pmc Controlling the response: predictive modeling of a highly central, pathogen-targeted core response module in macrophage activation
    Jason E McDermott
    Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, Washington, United States of America
    PLoS ONE 6:e14673. 2011
    We have investigated macrophage activation using computational analyses of a compendium of transcriptomic data covering responses to agonists of the TLR pathway, Salmonella infection, and manufactured amorphous silica nanoparticle ..
  33. ncbi SOCS proteins, cytokine signalling and immune regulation
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Rev Immunol 7:454-65. 2007
    ..In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function...
  34. pmc Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
    Minna U Kaikkonen
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Mol Cell 51:310-25. 2013
    ..Collectively, these findings suggest an essential role of enhancer transcription in H3K4me1/2 deposition at de novo enhancers that is independent of potential functions of the resulting eRNA transcripts. ..
  35. pmc Human macrophage activation programs induced by bacterial pathogens
    Gerard J Nau
    Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:1503-8. 2002
    ..These results improve our understanding of macrophage defenses, provide insights into mechanisms of pathogenesis, and suggest targets for therapeutic intervention...
  36. ncbi SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
    Ichiko Kinjyo
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Immunity 17:583-91. 2002
    ..Thus, SOCS1 directly suppresses TLR4 signaling and modulates innate immunity...
  37. ncbi Regulation of macrophage activation in alcoholic liver disease
    Varsha Thakur
    Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106 4906, USA
    J Gastroenterol Hepatol 22:S53-6. 2007
    ....
  38. doi Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activation
    Tonya Azevedo Duarte
    Health Science Institute, Federal University of Bahia, Salvador, BA, Brazil
    Tuberculosis (Edinb) 92:218-25. 2012
    ..We found that the ectosomes derived from infected neutrophils are biologically active and can influence the survival of Mycobacterium tuberculosis within macrophages...
  39. pmc Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation
    Sarah E Hardison
    Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
    J Immunol 189:4060-8. 2012
    ..neoformans infection in BALB/c mice is associated with polarized Th2-type cytokine production, alternative macrophage activation, and severe bronchopneumonia. In contrast, pulmonary infection with a C...
  40. pmc Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism
    Kari Ann Shirey
    Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:4159-67. 2008
    ..Thus, redirection of macrophage differentiation by Ft LVS from a classical to an alternative activation state enables the organism to survive at the expense of the host...
  41. pmc Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation
    Aarash Bordbar
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Mol Syst Biol 8:558. 2012
    ..proteomics, and metabolomics) analysis to assess metabolic features that are critical for macrophage activation. We constructed a genome-scale metabolic network for the RAW 264...
  42. pmc RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins
    Antje Blumenthal
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Host Microbe 5:35-46. 2009
    ..kDa lipoprotein induced release of tumor necrosis factor in a manner dependent on both TLR2 and RP105, and macrophage activation by Mtb lacking mature lipoproteins was not RP105 dependent...
  43. ncbi The role of IL-10 in promoting disease progression in leishmaniasis
    M M Kane
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 166:1141-7. 2001
    ..The IL-10 produced by infected macrophages prevented macrophage activation and diminished their production of IL-12 and TNF-alpha...
  44. ncbi Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex
    Mitsuhiro Fujihara
    Japanese Red Cross, Hokkaido Red Cross Blood Center, Yamanote 2 2, Nishi ku, Sapporo 063 0002, Japan
    Pharmacol Ther 100:171-94. 2003
    ..In addition, recent therapeutic approaches for septic shock targeting the LPS receptor complex are described...
  45. ncbi Immunology of tuberculosis
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Immunol 19:93-129. 2001
    ..The pace of this research must be maintained if we are to realize an effective vaccine in the next decades...
  46. doi Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation
    Juan Carlos Rodríguez-Prados
    Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, Barcelona, Spain
    J Immunol 185:605-14. 2010
    ..Interestingly, macrophage activation through LPS/IFN-gamma or TLR-2, -3, -4, and -9 results in similar flux distribution patterns regardless of ..
  47. pmc Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages
    Ingo Klein
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, NY, USA
    Blood 110:4077-85. 2007
    ..Our conclusions resolve a long-standing controversy and explain how different experimental approaches may reveal one or both of these subsets...
  48. ncbi Cutting edge: TREM-2 attenuates macrophage activation
    Isaiah R Turnbull
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3520-4. 2006
    ..Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation.
  49. ncbi Macrophage activation syndrome
    Angelo Ravelli
    Pediatria II, Istituto G Gaslini, Universita di Genova, Italy
    Curr Opin Rheumatol 14:548-52. 2002
    b>Macrophage activation syndrome (MAS) is a serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T lymphocytes and macrophages...
  50. doi Alternative activation of macrophages: immune function and cellular biology
    Audrey Varin
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunobiology 214:630-41. 2009
    ....
  51. pmc Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation
    Kerstin Werninghaus
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University Munich, D 81675 Munich, Germany
    J Exp Med 206:89-97. 2009
    ..These data provide a molecular basis for the immunostimulatory activity of TDB and TDM and identify the Syk-Card9 pathway as a rational target for vaccine development against tuberculosis...
  52. ncbi The many faces of macrophage activation
    David M Mosser
    Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 73:209-12. 2003
  53. ncbi Regulation of alternative macrophage activation by galectin-3
    Alison C Mackinnon
    Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
    J Immunol 180:2650-8. 2008
    Alternative macrophage activation is implicated in diverse disease pathologies such as asthma, organ fibrosis, and granulomatous diseases, but the mechanisms underlying macrophage programming are not fully understood...
  54. pmc Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP
    Jonas Bystrom
    Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, United Kingdom
    Blood 112:4117-27. 2008
    ..Thus, rM macrophages are neither classically nor alternatively activated but a hybrid of both, with a role in mediating postresolution innate-lymphocyte repopulation and restoring tissue homeostasis...
  55. pmc Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway
    Berta Vidal
    Program on Differentiation and Cancer, Center for Genomic Regulation CRG, Pompeu Fabra University UPF, E 08003 Barcelona, Spain
    Genes Dev 22:1747-52. 2008
    ..Fibrinogen, by engaging its alphavbeta3 receptor on fibroblasts, also directly promotes collagen synthesis. These data unveil a profibrotic role of fibrinogen deposition in muscle dystrophy...
  56. pmc Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    Jia Xue
    Genomics and Immunoregulation, LIMES Institute, University of Bonn, 53115 Bonn, Germany
    Immunity 40:274-88. 2014
    b>Macrophage activation is associated with profound transcriptional reprogramming...
  57. doi Modulation of macrophage activation and programming in immunity
    Guangwei Liu
    Department of Immunology, Shanghai Medical College, Fudan University, Shanghai, PR China
    J Cell Physiol 228:502-12. 2013
    ..The concept of macrophage activation and program has stimulated interest in its definition, and functional significance in homeostasis and ..
  58. pmc Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent
    K A Shirey
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, Baltimore, MD, USA
    Mucosal Immunol 3:291-300. 2010
    ..RSV-infected cotton rats treated with a cyclooxygenase-2 inhibitor increased expression of lung AA-M phi. These data suggest new treatment strategies for RSV that promote AA-M phi differentiation...
  59. doi Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function
    Claire S Whyte
    Division of Applied Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
    J Leukoc Biol 90:845-54. 2011
    ..Together, our results uncover SOCS1, not only as a feedback inhibitor of inflammation but also as a critical molecular switch that tunes key signaling pathways to effectively program different sides of the macrophage balance...
  60. pmc Classical macrophage activation up-regulates several matrix metalloproteinases through mitogen activated protein kinases and nuclear factor-κB
    Wei Chun Huang
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    PLoS ONE 7:e42507. 2012
    ..In conclusion, classical macrophage activation selectively up-regulates several MMPs in vitro and in vivo and down-regulates TIMP-3, whereas alternative ..
  61. pmc MicroRNA-125b potentiates macrophage activation
    Aadel A Chaudhuri
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 187:5062-8. 2011
    ....
  62. pmc Macrophage activation by endogenous danger signals
    X Zhang
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Pathol 214:161-78. 2008
    ..b>Macrophage activation plays a critical role, not only in the initiation of the inflammatory response but also in the resolution ..
  63. pmc Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms
    Agnes M Scherbart
    IUF Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
    Part Fibre Toxicol 8:31. 2011
    ..The uptake of DQ12 was found to be significantly reduced by all three inhibitors. Our findings suggest that the contrasting AM responses to fTiO2 , ufTiO2 and DQ12 relate to differences in the involvement of specific uptake mechanisms...
  64. pmc FIZZ1 and Ym as tools to discriminate between differentially activated macrophages
    Geert Raes
    Department of Molecular and Cellular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Dev Immunol 9:151-9. 2002
    ..Finally, we show that these genes can be used to monitor the macrophage activation status without the need to obtain pure macrophage populations.
  65. pmc Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice
    M J G Johnston
    Gastrointestinal Research Group, Department of Physiology and Pharmacology, Calvin, Phoebe, and Joan Snyder Institute of Infection, Immunity, and Inflammation, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 1N4, Canada
    Infect Immun 78:1364-75. 2010
    ..A high-molecular-mass fraction of adult H. diminuta (HdHMW) or excretory/secretory products reduced macrophage activation: lipopolysaccharide (LPS)-induced interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha (TNF-..
  66. doi Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat
    Sarah B Withers
    Cardiovascular Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom
    Arterioscler Thromb Vasc Biol 31:908-13. 2011
    ....
  67. ncbi Adipose tissue macrophages
    Maximilian Zeyda
    Department of Internal Medicine III, Clin Div Endocrinology and Metabolism, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Immunol Lett 112:61-7. 2007
    ..Strategies to interfere with ATM recruitment and adverse activation could give rise to novel options for treatment and prevention of insulin resistance and type 2 diabetes mellitus...
  68. doi Taenia crassiceps infection abrogates experimental autoimmune encephalomyelitis
    Jose L Reyes
    Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Tlalnepantla, Edo, México 54090, Mexico
    Cell Immunol 267:77-87. 2011
    ..Furthermore, in these mice, there was reduced entry of CD3(+)Foxp3(-) cells into the brain. The T. crassiceps-induced immune regulation decreased EAE severity by dampening T cell activation, proliferation and migration to the CNS...
  69. ncbi Oligodendrocyte generation is differentially influenced by toll-like receptor (TLR) 2 and TLR4-mediated intraspinal macrophage activation
    David L Schonberg
    Neuroscience Graduate Studies Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Neuropathol Exp Neurol 66:1124-35. 2007
    ..To examine the relationship between oligodendrocyte generation and macrophage activation in vivo, we compared the extent of oligodendrocyte loss and NG2 cell proliferation and differentiation ..
  70. doi Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia
    Subhankar Mukhopadhyay
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
    Cell Host Microbe 8:236-47. 2010
    b>Macrophage activation is essential for protection against bacterial pathogens but needs to be regulated to prevent damage to the host...
  71. pmc Arginase in parasitic infections: macrophage activation, immunosuppression, and intracellular signals
    Cinthia C Stempin
    Inmunologia, CIBICI CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina
    J Biomed Biotechnol 2010:683485. 2010
    ..However, they affect disease outcome by promoting parasite survival and proliferation. Thus, modulation of macrophage activation may be instrumental in allowing parasite persistence and long-term host survival.
  72. doi A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages
    Wei Xia
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Blood 113:438-46. 2009
    ..These results suggest that FR constitutes a marker for macrophage activation and that FR(+) macrophages can be targeted with folate-linked drugs without promoting drug uptake by ..
  73. pmc Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
    Divya Vats
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine and Graduate Program in Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Metab 4:13-24. 2006
    ..elucidate a molecular pathway that directly links mitochondrial oxidative metabolism to the anti-inflammatory program of macrophage activation, suggesting a potential role for metabolic therapies in treating atherogenic inflammation.
  74. doi The resolution of inflammation: anti-inflammatory roles for NF-kappaB
    Toby Lawrence
    Inflammation Biology Group, Centre d Immunologie Marseille Luminy, CNRS Inserm Université de la Méditerranée, Parc Scientifique de Luminy, 13288 Marseille, France
    Int J Biochem Cell Biol 42:519-23. 2010
    ..In this review we will discuss the emerging role of NF-kappaB in the resolution of inflammation and some of the potential mechanisms attributed to this function...
  75. pmc Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006
    ..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions...
  76. pmc Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    M Stein
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Exp Med 176:287-92. 1992
    ....
  77. ncbi Toll receptors, CD14, and macrophage activation and deactivation by LPS
    Marina A Dobrovolskaia
    Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Microbes Infect 4:903-14. 2002
    This review will focus on the molecular mechanisms of macrophage activation and desensitization by bacterial lipopolysaccharide (LPS)...
  78. ncbi Reduced expression of the inducible nitric oxide synthase after infection with Toxoplasma gondii facilitates parasite replication in activated murine macrophages
    Carsten G K Lüder
    Department of Bacteriology, Georg August University Gottingen, Kreuzbergring 57, D 37075 Gottingen, Germany
    Int J Parasitol 33:833-44. 2003
    ..Nitric oxide production and its partial inhibition by the parasite may modulate the parasite-host equilibrium during toxoplasmosis...
  79. ncbi Granulocyte apoptosis and its role in the resolution and control of lung inflammation
    C Haslett
    Rayne Laboratories, University of Edinburgh, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 160:S5-11. 1999
    ..Furthermore, such differences may lead to novel therapies based on the specific induction of eosinophil apoptosis. Haslett C. Granulocyte apoptosis and its role in the resolution and control of lung inflammation...
  80. ncbi Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages
    Mark W Feinberg
    Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:38247-58. 2005
    ..such as interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), or tumor necrosis factor-alpha can promote macrophage activation. Conversely, anti-inflammatory factors such as transforming growth factor-beta1 (TGF-beta1) can decrease ..
  81. ncbi Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease
    Y Wang
    Centre for Transplantation and Renal Research, The University of Sydney at Westmead Millennium Institute, Westmead, New South Wales, Australia
    Kidney Int 72:290-9. 2007
    ..Our findings demonstrate that macrophages not only act as effectors of immune injury but can be induced to provide protection against immune injury...
  82. ncbi IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans
    Uwe Muller
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    J Immunol 179:5367-77. 2007
    ..This indicates that IL-13 contributes to fatal allergic inflammation during C. neoformans infection...
  83. pmc Macrophage activation governs schistosomiasis-induced inflammation and fibrosis
    Luke Barron
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 41:2509-14. 2011
    ..These studies have shown that AAMϕs protect mice from acute and chronic S. mansoni infection through distinct mechanisms, which are discussed in this Viewpoint...
  84. ncbi Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection
    P ng Loke
    Tropical Disease Research Unit, University of California, San Francisco, CA 94143, USA
    J Immunol 179:3926-36. 2007
    ..However, analogous to classical activation by microbial pathogens, Th2 cells are required for maintenance and full activation during the ongoing response to metazoan parasites...
  85. ncbi M-1/M-2 macrophages and the Th1/Th2 paradigm
    C D Mills
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    J Immunol 164:6166-73. 2000
    ..Together, the results indicate that M-1- or M-2-dominant macrophage responses can influence whether Th1/Th2 or other types of inflammatory responses occur...
  86. pmc Alternative macrophage activation and metabolism
    Justin I Odegaard
    Department of Pathology, Stanford University School of Medicine, California 94305 5103, USA
    Annu Rev Pathol 6:275-97. 2011
    ..than representing simple inflammatory disease, obesity and metabolic syndrome represent derangements in macrophage activation with concomitant loss of metabolic coordination...
  87. pmc Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice
    Roham Parsa
    Applied Immunology, Center for Molecular Medicine, Karolinska University Hospital at Solna, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Diabetes 61:2881-92. 2012
    ..We suggest that M2r macrophage therapy represents a novel intervention that stops ongoing autoimmune T1D and may have relevance in a clinical setting...
  88. pmc Biomarkers of microbial translocation and macrophage activation: association with progression of subclinical atherosclerosis in HIV-1 infection
    Theodoros Kelesidis
    Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90035, USA
    J Infect Dis 206:1558-67. 2012
    ..The relationships between soluble CD14 (sCD14), endotoxin (lipopolysaccharide [LPS]), and progression of atherosclerosis have not been defined in human immunodeficiency virus (HIV) infection...
  89. pmc Polarization dictates iron handling by inflammatory and alternatively activated macrophages
    Gianfranca Corna
    H San Raffaele Institute, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    Haematologica 95:1814-22. 2010
    ..Little is known on whether the polarization program influences the ability of macrophages to store or recycle iron and the molecular machinery involved in the processes...
  90. pmc Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy
    Mark A Wallet
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, USA
    AIDS 24:1281-90. 2010
    ..HIV-1 replication and microbial translocation occur concomitant with systemic immune activation. This study delineates mechanisms of immune activation and CD4 T-cell decline in pediatric HIV-1 infection...
  91. ncbi Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation
    Geert Raes
    Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Building E, Level 8, Pleinlaan 2, B 1050 Brussels, Belgium
    J Leukoc Biol 77:321-7. 2005
    ..Moreover, we show that expression of MGL on human monocytes is also up-regulated by IL-4. Hence, macrophage galactose-type C-type lectins represent novel surface markers for murine and human aaMF...
  92. ncbi Macrophage-derived factors stimulate optic nerve regeneration
    Yuqin Yin
    Laboratories for Neuroscience Research in Neurosurgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 23:2284-93. 2003
    ..Lens injury induces macrophage activation, and we show here that factors secreted by macrophages stimulate RGCs to regenerate their axons...
  93. doi M2 macrophages phagocytose rituximab-opsonized leukemic targets more efficiently than m1 cells in vitro
    Marzia Leidi
    Ospedali Riuniti di Bergamo, Italy
    J Immunol 182:4415-22. 2009
    ..Our data suggest that cytokines secreted by lymphoma cells can favor alternate activation of macrophages with a high phagocytic capacity toward rituximab-opsonized targets...
  94. pmc Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms
    Xiaoyu Hu
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, USA
    Immunol Rev 226:41-56. 2008
    ..b>Macrophage activation needs to be tightly regulated to rapidly mount responses to infectious challenges but to avoid toxicity ..
  95. pmc Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection
    A Castrillo
    Instituto de Bioquímica Centro Mixto Consejo Superior de Investigaciones Cientificas UCM, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
    J Exp Med 194:1231-42. 2001
    ..Furthermore, we demonstrate that in the absence of PKCepsilon, host defense against bacterial infection is severely compromised, resulting in an increased incidence of mortality...
  96. doi Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue
    Takayoshi Suganami
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Circ Res 105:25-32. 2009
    ..overexpression of ATF3 specifically in macrophages results in the marked attenuation of proinflammatory M1 macrophage activation in the adipose tissue from genetically obese KKA(y) mice fed high-fat diet...
  97. doi Macrophage activation and polarization as an adaptive component of innate immunity
    Massimo Locati
    Humanitas Clinical and Research Center, Rozzano, Milan, Italy Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy
    Adv Immunol 120:163-84. 2013
    ..The definition of molecules and mechanisms associated with plasticity and polarized activation of macrophages may provide a basis for innovative diagnostic and therapeutic approaches. ..
  98. ncbi A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis
    Dana G Mordue
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Leukoc Biol 74:1015-25. 2003
    ..Our findings suggest that activated CD68+/Gr-1+ macrophages contribute to parasite control during infection by directly inhibiting parasite replication and through production of T helper cell type I cytokines...
  99. pmc LIMP-2 links late phagosomal trafficking with the onset of the innate immune response to Listeria monocytogenes: a role in macrophage activation
    Eugenio Carrasco-Marin
    Servicio de Inmunologia, Hospital Santa Cruz de Liencres y Fundación Marqués de Valdecilla Instituto de Formación e Investigación Marqués de Valdecilla, 39120 Liencres, Spain
    J Biol Chem 286:3332-41. 2011
    ....
  100. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
    ..Chitin mediated alternative macrophage activation in vivo and the production of leukotriene B(4), which was required for optimal immune cell recruitment...
  101. pmc Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication
    Ana Cristina Docan Dragomir
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    J Immunol 189:5934-41. 2012
    ..accumulating in the liver following APAP intoxication and evaluated the role of galectin-3 (Gal-3) in macrophage activation. Administration of APAP (300 mg/kg, i.p...

Research Grants71

  1. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Alternative macrophage activation limits immunopathology Macrophages (MF) form a heterogeneous population of mononuclear phagocytes necessary for organ homeostasis, host defense, and immunoregulation...
  2. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..We then investigate the functional changes in adipocytes and macrophage activation in white and brown adipose tissues on early adipocyte progenitor cell (APC), in vivo adipogenesis, newly ..
  3. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..primarily expressed on monocytes/macrophages and dendritic cells (DCs) that is a marker for monocyte/macrophage activation and participates in monocyte recruitment...
  4. Hormonal regulation of a Ca2+/AMPK signaling pathway
    Anthony R Means; Fiscal Year: 2013
    ..a key role in mediating the cellular signals initiated by Toll-like receptors (TLRs), thereby affecting macrophage activation and inflammatory responses...
  5. The Role of Substrate Metabolism and Macrophage Activation in Obesity
    Amy Johnson; Fiscal Year: 2013
    ....
  6. Interventions Against the Molecular Etiology of BMPR2-induced PAH
    James D West; Fiscal Year: 2013
    ..and this in combination with increased ROS may drive recruitment of monocytes and alternative (M2) macrophage activation, which can drive pathologic changes to the pulmonary vasculature in their microenvironment...
  7. Role of Inflammation in the Pathobiology of Abdominal Aortic Aneurysm
    KATHLEEN RAMAN; Fiscal Year: 2013
    ..Thus, the specific aims of this proposal are: Aim #1: Determine if RAGE-mediated signaling alters macrophage activation and polarization underlying the proinflammatory pathophysiology of AAA...
  8. Atherogenic mechanism of lipid peroxidation-derived aldehydes
    Sanjay Srivastava; Fiscal Year: 2013
    ..aims of this project are to: (1) delineate the contribution of ER stress and UPR to aldehyde-mediated macrophage activation;(2) elucidate the role of UPR in regulating atherogenesis;and (3) examine the role of aldehyde metabolism ..
  9. Harness Germinal Matrix Hemorrhage
    John H Zhang; Fiscal Year: 2013
    ..Our second corollary hypothesis is that enhancing blood clot resolution and clearance, via macrophage activation, will effectively reduce hydrocephalus and consequent neurological deficits after GMH...
  10. Free Radical Mechanism in Obesity Potentiation of Environmental Hepatotoxicity
    Saurabh Chatterjee; Fiscal Year: 2013
    ..such as bromodichloromethane, a DBP, This aim will be achieved by investigating free radical-induced macrophage activation and cell death in Ieptin knockout mice and using neutralizing antibodies against Ieptin.
  11. Role of Protein Kinase C in Macrophage Activation
    Michelle R Lennartz; Fiscal Year: 2012
    ..Understanding membrane remodeling using phagocytosis as a model system will advance our knowledge of the innate immune system and may be applicable to other cell processes, including tumor metastasis and wound healing. ..
  12. ERK Signaling in Inflammatory Bone Loss
    Francis Young In Lee; Fiscal Year: 2013
    ..Aim 2 will determine whether CRG regulates macrophage activation in inflammatory osteolysis in vitro and in vivo...
  13. Role of Brain-Specific microRNAs in Suppression of Autoimmune Neuroinflammation
    Howard L Weiner; Fiscal Year: 2013
    ..Further analysis demonstrated that miR-124 inhibited macrophage activation by targeting CEBP[unreadable], a transcription factor responsible for the differentiation of myeloid ..
  14. Molecular Basis of the Anti-inflammatory Action of MAYP/PSTPIP2
    Violeta Chitu; Fiscal Year: 2012
    ..The overall aim of this proposal is to establish the molecular basis of MAYP action in regulating macrophage activation. The specific aims are to: 1...
  15. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
    ..These studies should provide novel insights into differential gene regulation in macrophages under conditions that induce "M2d" activation. ..
  16. Role of BH3-domain proteins in the effector phase of RA
    HARRIS R PERLMAN; Fiscal Year: 2012
    ..A.4. Determine the mechanism of Bim-mediated suppression of macrophage activation. The regulation of cell death and growth is vital for maintaining a balance in the human body...
  17. KLF2, monocyte activation and vascular inflammation
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..and under the auspices of this grant, identified KLF2 as an endogenous repressor of proinflammatory macrophage activation. Specifically, KLF2 was shown to regulate two ancient stress pathways central to activation of the innate ..
  18. Genetic dissection of the role of macrophages in axonal myelination in zebrafish
    Celia E Shiau; Fiscal Year: 2012
    ..Phenotypic studies, including marker studies, cell transplantation, uitrastructural analysis, macrophage activation analyses, and time-lapse imaging if the effect involves abnormal cell migration, will define the function ..
  19. Application of Carbon Nanotubes for Macrophage Activation in Brain Tumor Models
    Behnam Badie; Fiscal Year: 2010
    ..Furthermore, modification of brain macrophages with CNT may have therapeutic relevance to other CNS disease processes, such as trauma and stroke, where brain macrophages play a key role in their pathogenesis. ..
  20. HIF-1alpha Mediated Wound Healing in Periapical Lesion
    Hajime Sasaki; Fiscal Year: 2013
    ..of this proposal is that HIF-1a activation leads to periapical wound healing via induction of M1 macrophage activation followed by emergence of M2 to facilitate final clearance of the lesion...
  21. Role of heat shock protein 90 in alcoholic liver disease
    Pranoti Mandrekar; Fiscal Year: 2013
    ..Alcohol-induced oxidative stress plays an important part in macrophage activation. Heat shock proteins are induced by oxidative stress and function as molecular chaperones...
  22. Activation of Macrophages in Human Autoimmune Diseases
    Lionel B Ivashkiv; Fiscal Year: 2013
    ..advances in the genetics of human autoimmune diseases have linked allelic variants of genes important in macrophage activation with human autoimmune diseases...
  23. Adipokine Signaling in Macrophages
    Ling Qi; Fiscal Year: 2013
    ..data support the notion that macrophage TORC2 (for Transducers Of Regulated CREB activity 2) controls macrophage activation via a unique mechanism, involving nuclear-cytosolic shuttling of TORC2, upon stimulation by specific ..
  24. Influence of Macrophage NF-kB Activation on the Outcome of Pneumococcal Pneumonia
    FADIE THOMAS COLEMAN; Fiscal Year: 2013
    ..different pneumococcal isolates vary in their ability to activate macrophage NF-?B and those that subvert macrophage activation are more capable of causing severe pneumonia...
  25. Effect of breast feeding on immunologic priming in young infants.
    John W Sleasman; Fiscal Year: 2013
    ..the extent of B cell class switch recombination, levels of pro-inflammatory cytokines, extent of macrophage activation, and capacity of neonatal monocytes/macrophages to produce BAFF and APRIL following activation via Toll-..
  26. Mechanisms by which IL-10 limits Toll-like Receptor 9 mediated Macrophage Activat
    Scott Canna; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Macrophage Activation Syndrome (MAS) is an uncommon but potentially life-threatening complication of many infectious, malignant and rheumatic diseases...
  27. Study of gamma interferon agonists/mimetics
    Howard M Johnson; Fiscal Year: 2012
    ..Important aspects of innate immunity, adaptive immunity, macrophage activation, natural killer cell activity, helper T cell responses, as well as cytotoxic T cell responses are all ..
  28. Regulation of Macrophage Activation by House Dust Mite
    Achsah D Keegan; Fiscal Year: 2013
    ..necessary for HDM-induced effects on macrophages in vitro, we will analyze the importance of the sensor in macrophage activation and allergic lung inflammation in vivo using a mouse model of HDM-induced asthma...
  29. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Peter S Tobias; Fiscal Year: 2012
    ..A major characteristic of macrophage activation is the production of pro-inflammatory cytokines, bioactive lipids, degradative enzymes, etc...
  30. Glutaminase: neurotoxic link in HIV-1 Associated Dementia
    JIALIN CHARLES ZHENG; Fiscal Year: 2013
    ..This project will develop assays that investigate brain macrophage activation, miRNA23a/b regulation, mitochondrial stress and neuronal injury that occur in HAD...
  31. The regulation of inflammation and phagocytosis by CD93
    SUZANNE BOHLSON; Fiscal Year: 2009
    ..This proposal tests the hypothesis that CD93 regulates monocyte/macrophage activation extracellularly via its membrane tethered or soluble ectodomain, as well as intracellularly via protein ..
  32. Nuclear receptor mechanisms controlling macrophage function in health and disease
    Ajay Chawla; Fiscal Year: 2013
    ..Recent studies indicate that expression of nuclear receptor superfamily is dynamically modulated during macrophage activation, indicating that these receptors play a pivotal role in orchestrating macrophage transcriptional responses...
  33. Adipose Tissue Inflammation and Vascularity
    Kenneth Walsh; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): It is becoming increasingly appreciated that adipose tissue macrophage activation plays an important role in the development of chronic inflammation and metabolic dysfunction associated with obesity...
  34. RELM-alpha regulation of hookworm-induced lung inflammation
    MEERA GOH NAIR; Fiscal Year: 2013
    ..2 will employ both Nb infection and an in vivo model of lung basophilia to examine how basophils mediate macrophage activation and expression of RELMa...
  35. The role of MCPIP1 in regulating NF-kB signaling and macrophage activation
    Mingui Fu; Fiscal Year: 2012
    ..of TRAFs as an essential mechanism in the regulation of NF-[unreadable]B signaling as well as macrophage activation both in vitro and in vivo...
  36. Formation of Omega 3-Derived Electrophiles During Inflammation
    FRANCISCO JOSE SCHOPFER; Fiscal Year: 2013
    ..An electrophilic mapping of lipids formed during macrophage activation showed that keto-derived w-3 fatty acids omega 3 derived-fatty acids were present at intracellular ..
  37. Alternative macrophage activation in acute Pseudomonas pneumonia
    DAVID FEOLA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alternative macrophage activation regulates inflammatory responses to pathogenic organisms. Most work to date has characterized their role in Th2-type immune responses...
  38. The roles of Sirt1, a deacetylase, in immune tolerance and autoimmunity
    Deyu Fang; Fiscal Year: 2013
    ..discovered that the type III histone deacetylase Sirt1 as a critical suppressor to T cell immunity and macrophage activation by suppressing the transcription factors AP-1, indicating Sirt1 as a potential therapeutic target for ..
  39. TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
    Mark E Lauer; Fiscal Year: 2013
    ..and ligands whereby TSG-6 stimulates HA synthesis, (ii) determine the effect HC-HA has on monocyte/macrophage activation, and (iii) evaluate the ability of TSG-6 to amplify HA synthesis in cooperation with a "live" respiratory ..
  40. Effect of impaired macrophage autophagy on the development of fatty liver disease
    Kun Liu; Fiscal Year: 2012
    ..hypothesis by delineating the mechanisms by which autophagy-mediated effects on lipid breakdown regulate macrophage activation in studies contained in three Specific Aims...
  41. IMAGING MACROPHAGE ACTIVATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Delphine L Chen; Fiscal Year: 2013
    ..b>Macrophage activation is critical to disease progression, so a technique that can track macrophage recruitment and activation in ..
  42. CD80 and CD86 mediated innate immune response in sepsis
    Anna Nolan; Fiscal Year: 2013
    ..An in vitro model using neutrophil (PMN)/macrophage co-culture leads to macrophage activation by a CD80/86 dependent pathway...
  43. Eosinophils and lung immunity to Pneumocystis
    Chad Steele; Fiscal Year: 2013
    ..mice) clear Pneumocystis murina more efficiently than control mice as a result of an enhanced alternative macrophage activation (M2a) signature. Our studies now show that M2a polarization develops rapidly after P...
  44. Modulation of host innate immune response by Francisella tularensis
    Chandra Shekhar Bakshi; Fiscal Year: 2013
    ..are important virulence factors and play an essential role in the suppression of kinase signaling and macrophage activation. In this application, we wish to dig deeper to expose the link between efficient ROS scavenging capacity ..
  45. PPAR gamma as a therapeutic target in COPD
    Thomas J Mariani; Fiscal Year: 2013
    ..to regulate the expression of epithelial-derived chemokines involved in inflammatory cell recruitment, macrophage activation and tissue destruction in response to chronic smoke exposure...
  46. Neurotrophin- Chemokine Receptor Interactions Regulate Macrophage Activation
    KIMBERLY S WILLIAMS; Fiscal Year: 2013
    ....
  47. Acute alcohol and calcium-dependent LPS-triggered activation of macrophages
    Angela Dolganiuc; Fiscal Year: 2013
    ..research proposal is to define the influence of alcohol on the molecular mechanisms involved in regulation macrophage activation. Macrophages (Mf) produce pro-inflammatory cytokine TNF? when a bacterial- derived product, ..
  48. Novel Immunologic Effects of Semaphorin 7a in IPF
    Erica L Herzog; Fiscal Year: 2013
    ..7a on CD4+ lymphocytes with the [unreadable]1-integrin and Netrin-1 on monocytes that leads to alternative macrophage activation and pulmonary fibrosis...
  49. A role for IL-1 in SJIA monocyte phenotypes: A RAPPORT ancillary study
    Elizabeth D Mellins; Fiscal Year: 2013
    ..Although the etiology is unknown, SJIA complications such as macrophage activation syndrome and amyloidosis support involvement of the innate immune system, as do the paucity of ..
  50. Restoring Iron Homeostasis to Promote Recovery after Spinal Cord Injury
    Dana M McTigue; Fiscal Year: 2013
    ..spinal cord for several weeks and this dysregulation is exacerbated when highly conserved mechanisms of macrophage activation are impaired...
  51. The role of adenosine kinase in atherosclerosis
    Yuqing Huo; Fiscal Year: 2013
    ..the effects of monocyte ADK deficiency on the decline of monocyte recruitment to atherosclerotic arteries, macrophage activation and foam cell formation, as well as the growth of advanced atherosclerotic lesions...
  52. Atherogenic Mechanisms of Arsenic
    Sanjay Srivastava; Fiscal Year: 2013
    ..we will: (1) delineate the contribution of ER stress and UPR to arsenic-mediated endothelial cell and macrophage activation;(2) examine the progression of atherogenesis in arsenic-exposed mice;and (3) elucidate the role of UPR in ..
  53. Mechanisms of Liver Inflammation
    Harmeet Malhi; Fiscal Year: 2013
    ..binding protein (XBP-1) branch of the UPR increases the proinflammatory milieu in the liver by enhancing macrophage activation and cytokine secretion via targeting the cytokines monocyte chemotactic protein-1 (MCP-1) and interleukin-..
  54. Role of Macrophage Activation in Carotid Plaque Instability
    Michelle R Lennartz; Fiscal Year: 2010
    ..Our data suggest that FcR signaling in involved in the development of unstable plaques. This research will determine the role of FcgR in plaque progression and rupture and provide novel targets for reducing heart attack and stroke. ..
  55. YKL-40 in Idiopathic Pulmonary Fibrosis and Kidney Transplantation
    Jack A Elias; Fiscal Year: 2013
    ..CLP (YKL-40 in man and BRP-39 in the mouse) is a circulating regulator of apoptosis, alternative (M2) macrophage activation and TGF-bi elaboration and tissue fibrosis...
  56. The roles of Sirt1, a deacetylase, in immune tolerance and autoimmunity
    Deyu Fang; Fiscal Year: 2012
    ..discovered that the type III histone deacetylase Sirt1 as a critical suppressor to T cell immunity and macrophage activation by suppressing the transcription factors AP-1, indicating Sirt1 as a potential therapeutic target for ..
  57. Array development of anti-inflammatory peptoid-graft polymers for islet delivery
    Matthew Webber; Fiscal Year: 2013
    ..While a lot is known about the effect of surface chemistry on classical inflammatory macrophage activation, little is known about its effect on this alternative activation phenotype...
  58. Development of a Cell-Based HTS for Inhibitors of Inflammatory Macrophages
    David G Russell; Fiscal Year: 2013
    ..plate assay to screen for inhibitors that block either the induction or the downstream consequences of macrophage activation. Aim 3. Validation and functional classification of the "hits" obtained in the primary screen...
  59. Defining Microbial and Host Factors in Innate Immune Responses in Lyme Arthritis
    Klemen Strle; Fiscal Year: 2013
    ..Antibiotic-refractory Lyme arthritis may be, at least in part, a syndrome of inappropriate macrophage activation involving both microbial and host genetics...
  60. Lung tumor associated macrophages
    LORI NIELD; Fiscal Year: 2012
    ..We propose a series of in vivo modulations of macrophage activation to determine how these inflammatory phenotypes affect lung tumorigenesis in mouse models...
  61. Inhibition of Liver Macrophage activation in SIV infected macaques
    Donald L Sodora; Fiscal Year: 2013
    ..Through an inhibition of liver macrophage activation in the SIV- macaque model, we will determine if targeting liver macrophages is a potential strategy for ..
  62. Echium Oil Modulates Macrophage Inflammation by Promoting Alternative Activation
    AMANDA WIBLEY; Fiscal Year: 2010
    ..and alternative approaches to medicine geared toward understanding the molecular mechanisms of macrophage activation. It addresses the possibility that omega-3 fatty acids, like those found in fish oil, modulate ..
  63. REGULATION OF THE TUMORICIDAL MACROPHAGE PHENOTYPE
    David Riches; Fiscal Year: 1991
    b>Macrophage activation is a two step stimulus-driven process of differentiation that, upon completion, endows the macrophage with the capacity to recognize and destroy neoplastic target cells...
  64. The Cholinergic Anti-Inflammatory Pathway in Human Obesity and Insulin Resistance
    Karen Teff; Fiscal Year: 2009
    ..In obese, insulin resistant subjects, macrophage activation increases release of inflammatory cytokines and there is increased macrophage accumulation in adipose ..
  65. Cytokine Signaling in Autoimmune APC Dysfunction
    Sally Litherland; Fiscal Year: 2005
    ..make this pathway a key 'switch' mechanism for both myeloid differentiation stage-specific and monocyte/macrophage activation-specific responses to GM-CSF...
  66. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2002
    ..chaffeensis infections; 3) Macrophage activation contributes to the clearance of E. chaffeensis...
  67. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2007
    ..chaffeensis infections; 3) Macrophage activation contributes to the clearance of E. chaffeensis...
  68. BONE RESORPTION--IMMUNE AND ENDOCRINE RELATIONSHIPS
    STEVEN POPOFF; Fiscal Year: 1999
    ..This laboratory recently demonstrated a defect in inflammation-primed macrophage activation resulting from the inability to convert serum vitamin D binding protein ...
  69. Funtional Genomics of Interferon for Tuberculosis
    Richard Pine; Fiscal Year: 2005
    ..by TH1 lymphocytes in tuberculosis and is an essential mediator of the cellular immune response, producing macrophage activation. Signaling is transduced through activation of STAT-1, a latent transcription factor, and leads to induced ..
  70. MACROPHAGE ACTIVATION AND LIPOPROTEIN METABOLISM
    Maria Lopes Virella; Fiscal Year: 2001
    ..Furthermore, we will determine whether factors released during macrophage activation mediate or facilitate the increase in LDL receptor cell surface expression...
  71. REGULATION OF CSF 1 AND UROKINASE IN OVARIAN CANCER
    SETSUKO CHAMBERS; Fiscal Year: 1999
    ..Although during macrophage activation, the active cytokine CSF-1 stimulates the secretion of urokinase-type plasminogen activator (uPA) ..