immunologic memory

Summary

Summary: The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.

Top Publications

  1. pmc HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
    Michael R Betts
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 107:4781-9. 2006
  2. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
  3. pmc HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    Nicolas Chomont
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal Saint Luc, Montreal, Quebec, Canada
    Nat Med 15:893-900. 2009
  4. ncbi Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
  5. pmc Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Nature 473:523-7. 2011
  6. pmc A human memory T cell subset with stem cell-like properties
    Luca Gattinoni
    Center for Cancer Research, National Cancer Institute, US National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Med 17:1290-7. 2011
  7. pmc CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
    J Exp Med 200:749-59. 2004
  8. pmc mTOR regulates memory CD8 T-cell differentiation
    Koichi Araki
    Emory Vaccine Center and Department of Microbiology and Immunology, Atlanta, Georgia, USA
    Nature 460:108-12. 2009
  9. ncbi T-cell quality in memory and protection: implications for vaccine design
    Robert A Seder
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:247-58. 2008
  10. ncbi Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009

Detail Information

Publications345 found, 100 shown here

  1. pmc HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
    Michael R Betts
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 107:4781-9. 2006
    ..Thus, rather than quantity or phenotype, the quality of the CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy...
  2. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
    ....
  3. pmc HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    Nicolas Chomont
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal Saint Luc, Montreal, Quebec, Canada
    Nat Med 15:893-900. 2009
    ....
  4. ncbi Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
    ..This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice...
  5. pmc Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Nature 473:523-7. 2011
    ..Thus, persistent vectors such as CMV and their associated T(EM) responses might significantly contribute to an efficacious HIV/AIDS vaccine...
  6. pmc A human memory T cell subset with stem cell-like properties
    Luca Gattinoni
    Center for Cancer Research, National Cancer Institute, US National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Med 17:1290-7. 2011
    ..The identification of a human stem cell-like memory T cell population is of direct relevance to the design of vaccines and T cell therapies...
  7. pmc CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
    J Exp Med 200:749-59. 2004
    ....
  8. pmc mTOR regulates memory CD8 T-cell differentiation
    Koichi Araki
    Emory Vaccine Center and Department of Microbiology and Immunology, Atlanta, Georgia, USA
    Nature 460:108-12. 2009
    ..Thus these studies identify a molecular pathway regulating memory formation and provide an effective strategy for improving the functional qualities of vaccine- or infection-induced memory T cells...
  9. ncbi T-cell quality in memory and protection: implications for vaccine design
    Robert A Seder
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:247-58. 2008
    ....
  10. ncbi Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
    ..Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology...
  11. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
    ..Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization...
  12. ncbi Cell-mediated immune responses in tuberculosis
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Annu Rev Immunol 27:393-422. 2009
    ..We must also determine how to induce both known and novel immunoprotective responses without inducing immunopathologic consequences...
  13. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
    ..Thus, functional exhaustion is probably due to both active suppression and passive defects in signaling and metabolism. These results provide a framework for designing rational immunotherapies during chronic infections...
  14. ncbi CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    R Forster
    Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell 99:23-33. 1999
    ..Thus, in order to bring together lymphocytes and dendritic cells to form the characteristic microarchitecture of secondary lymphoid organs, CCR7 is required to rapidly initiate an adoptive immune response...
  15. ncbi Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
    Johannes F Scheid
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nature 458:636-40. 2009
    ..Thus, the IgG memory B-cell compartment in the selected group of patients with broad serum neutralizing activity to HIV is comprised of multiple clonal responses with neutralizing activity directed against several epitopes on gp120...
  16. pmc Adaptive immune features of natural killer cells
    Joseph C Sun
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California 94143, USA
    Nature 457:557-61. 2009
    ..These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system...
  17. pmc Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor
    Nikhil S Joshi
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:281-95. 2007
    ..These results elucidate a mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and, correspondingly, regulates their memory cell potential...
  18. pmc Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, and the Oregon National Primate Research Center, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Nat Med 15:293-9. 2009
    ..These data suggest a new paradigm for AIDS vaccine development--vaccines capable of generating and maintaining HIV-specific TEM cells might decrease the incidence of HIV acquisition after sexual exposure...
  19. ncbi Homeostasis of naive and memory T cells
    Charles D Surh
    The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 29:848-62. 2008
    ..Typical memory cells are kept alive and induced to divide intermittently by a mixture of IL-7 and IL-15. This review highlights recent advances in how naive and memory T cell homeostasis is regulated...
  20. ncbi Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    Onur Boyman
    Department of Immunology, IMM4, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 311:1924-7. 2006
    ..Thus, different cytokine-antibody complexes can be used to selectively boost or inhibit the immune response...
  21. ncbi Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:1236-44. 2005
    ..Therefore, these key transcription factors link the long-term renewal of memory CD8(+) T cells to their characteristic effector potency...
  22. pmc Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
    Ganesh A Kolumam
    Department of Immunology, University of Washington, Seattle, 98195, USA
    J Exp Med 202:637-50. 2005
    ..Thus, IFN-IR signaling in CD8 T cells is critical for the generation of effector and memory cells in response to viral infection...
  23. ncbi Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
    Ulf Klein
    Institute for Cancer Genetics, Department of Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nat Immunol 7:773-82. 2006
    ..These results identify IRF4 as a crucial transcriptional 'switch' in the generation of functionally competent plasma cells...
  24. pmc Enhancing CD8 T-cell memory by modulating fatty acid metabolism
    Erika L Pearce
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 460:103-7. 2009
    ..This treatment also increased CD8 T(M) cells in wild-type mice, and consequently was able to considerably improve the efficacy of an experimental anti-cancer vaccine...
  25. pmc Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates
    Surojit Sarkar
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:625-40. 2008
    ..These studies support the decreasing potential model of memory differentiation and show that the duration of antigenic stimulation is a critical regulator of memory formation...
  26. pmc Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
    Matthew E Pipkin
    Harvard Medical School, Boston, MA 02115, USA Immune Disease Institute, Boston, MA 02115, USA
    Immunity 32:79-90. 2010
    ..Thus, inflammation influences both effector and memory CTL differentiation, whereas persistent IL-2 stimulation promotes effector at the expense of memory CTL development...
  27. pmc IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
    Shlomo Z Ben-Sasson
    Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 106:7119-24. 2009
    ..These results indicate that IL-1beta signaling in T cells markedly induces robust and durable primary and secondary CD4 responses...
  28. pmc CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    Weihong Liu
    UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1701-11. 2006
    ..Finally, we show that CD127 can be used to quantitate T reg cell subsets in individuals with type 1 diabetes supporting the use of CD127 as a biomarker for human T reg cells...
  29. ncbi HIV preferentially infects HIV-specific CD4+ T cells
    Daniel C Douek
    Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
    Nature 417:95-8. 2002
    ..Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption...
  30. pmc Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells
    Thomas J Scriba
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, and School of Child and Adolescent Health, University of Cape Town, Observatory, South Africa
    Eur J Immunol 40:279-90. 2010
    ..This includes induction of novel Th1-cell populations that have not been previously described in humans...
  31. ncbi Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo
    Vandana Kalia
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunity 32:91-103. 2010
    ..Consistent with this, sustained IL-2 receptor signaling during expansion drove terminal-effector differentiation. These data support the hypothesis that prolonged IL-2 signals during priming promote terminal-effector differentiation...
  32. pmc Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells
    Marion Pepper
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Nat Immunol 11:83-9. 2010
    ..These results suggest that T(H)1 cells induced by intravenous infection are more efficient at entering the memory pool than are T(H)17 cells induced by intranasal infection...
  33. ncbi Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    K S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nat Immunol 1:426-32. 2000
    ..Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis...
  34. pmc Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
    ..Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence...
  35. pmc Dynamic T cell migration program provides resident memory within intestinal epithelium
    David Masopust
    Department of Microbiology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 207:553-64. 2010
    ..These data explain why systemic immunization routes induce local cell-mediated immunity within the intestine and indicate that this tissue must be seeded with memory T cell precursors shortly after activation...
  36. ncbi Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    T J Hamblin
    Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK
    Blood 94:1848-54. 1999
    ..0008). The simplest explanation is that CLL comprises 2 different diseases with different clinical courses. One, arising from a memory B cell, has a benign course, the other, arising from a naïve B cell, is more malignant...
  37. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  38. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011
    ..Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques...
  39. ncbi The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
    Rajesh R Rao
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Immunity 32:67-78. 2010
    ..Targeting mTOR activity offers new opportunities to regulate CD8+ T cell-mediated immunity...
  40. pmc Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    D Breitfeld
    Molecular Tumor and Immunogenetics, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Exp Med 192:1545-52. 2000
    ..Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells "follicular B helper T cells" (T(FH))...
  41. pmc Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:1797-805. 2008
    ..These data suggest that HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals...
  42. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  43. pmc Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
    Luca Gattinoni
    Center for Cancer Research, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 15:808-13. 2009
    ..These findings reveal a key role for Wnt signaling in the maintenance of 'stemness' in mature memory CD8(+) T cells and have major implications for the design of new vaccination strategies and adoptive immunotherapies...
  44. pmc Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    Marion Pepper
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Immunity 35:583-95. 2011
    ..Thus, Th1 effector memory and follicular helper-like central memory cells are produced from early effector cell populations that diverge in response to signals from the IL-2 receptor, Bcl6, and B cells...
  45. ncbi Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    Thomas Gebhardt
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne Victoria, Australia
    Nat Immunol 10:524-30. 2009
    ..Thus, these cells represent an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry...
  46. ncbi Immunity to respiratory viruses
    Jacob E Kohlmeier
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Annu Rev Immunol 27:61-82. 2009
    ....
  47. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
    ..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine...
  48. ncbi Antibodies, viruses and vaccines
    Dennis R Burton
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 2:706-13. 2002
    ..Several viruses, such as HIV, have evolved mechanisms to evade neutralizing-antibody responses, and these viruses present special challenges for vaccine design that are now being tackled...
  49. ncbi Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:639-46. 2007
    ..Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens...
  50. pmc Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
    Matthew A Williams
    Howard Hughes Medical Institute and Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 441:890-3. 2006
    ..These results have important implications for the development of vaccination or immunotherapeutic strategies aimed at boosting memory T-cell function...
  51. pmc Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation
    Shane Crotty
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 11:114-20. 2010
    ..Here we review and examine the commonalities and differences in the functions of these transcription factors in CD4(+) follicular helper T(FH) lymphocytes, effector CD8(+) T lymphocytes and B lymphocytes...
  52. pmc Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
    Jens Wrammert
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 453:667-71. 2008
    ..However, we found that most of the influenza-virus-specific mAbs showed the highest affinity for the current vaccine strain. Thus, OAS does not seem to be a common occurrence in normal, healthy adults receiving influenza vaccination...
  53. ncbi Antigen-specific memory B cell development
    Louise J McHeyzer-Williams
    The Scripps Research Institute, Department of Immunology, La Jolla, CA 92037, USA
    Annu Rev Immunol 23:487-513. 2005
    ..We review the cellular and molecular regulators of this dynamic process with emphasis on the multiple memory B cell fates that develop in vivo...
  54. pmc PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
    Simona Urbani
    Laboratorio Immunopatologia Virale, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, 43100 Parma, Italy
    J Virol 80:11398-403. 2006
    ..Blocking PD-1/PDL-1 interaction with an anti-PDL-1 antibody improved the capacity of expansion of virus-specific CD8 cells...
  55. pmc Cytokine-induced memory-like natural killer cells
    Megan A Cooper
    Rheumatology Division, Department of Medicine, and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:1915-9. 2009
    ..e., they do not exhibit memory of prior activation. By contrast, adaptive immune cells display immunologic memory that has 2 basic characteristics, antigen specificity and an amplified response upon subsequent exposure...
  56. pmc Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells
    Christopher A Klebanoff
    Howard Hughes Medical Institute, National Institutes of Health Research Scholars Program, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 102:9571-6. 2005
    ..Thus, tumor-reactive CD8+ T cell populations with the phenotypic and functional attributes of T(CM) may be superior to T(EM)/effector T cells for adoptive immunotherapies using concomitant tumor-antigen vaccination...
  57. ncbi An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus
    Elisabetta Traggiai
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Belllinzona, Switzerland
    Nat Med 10:871-5. 2004
    ..These results show that it is possible to interrogate the memory repertoire of immune donors to rapidly and efficiently isolate neutralizing antibodies that have been selected in the course of natural infection...
  58. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  59. pmc Defective CD8 T cell memory following acute infection without CD4 T cell help
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Science 300:339-42. 2003
    ..The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development...
  60. pmc Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro
    C A Spina
    The Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Clin Invest 99:1774-85. 1997
    ..Our results indicate that HIV replication is enhanced selectively in CD45RO memory phenotype cells through the probable contribution of specialized cellular factors which are produced during CD3-initiated signal transduction...
  61. pmc Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    Xiaodong Jiang
    Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:227-31. 2012
    ..These findings have important implications for our understanding of protective immune memory at epithelial interfaces with the environment, and suggest novel strategies for vaccines that protect against tissue tropic organisms...
  62. pmc Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
    Jonathan Sprent
    Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Nat Immunol 12:478-84. 2011
    ..The molecular mechanisms that control the conversion of naive resting T cells into memory-phenotype cells TCR-dependent in normal animals are beginning to be understood...
  63. ncbi IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...
  64. ncbi Germinal center selection and the development of memory B and plasma cells
    Mark J Shlomchik
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Immunol Rev 247:52-63. 2012
    ..We will discuss B-cell receptor signaling in the GC as it relates to potential mechanisms for affinity-based selection during the reaction...
  65. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
    ..These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity...
  66. pmc Complete but curtailed T-cell response to very low-affinity antigen
    Dietmar Zehn
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA
    Nature 458:211-4. 2009
    ....
  67. pmc Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Clin Invest 118:294-305. 2008
    ..These results could have significant implications for the selection of T cells to expand or to engineer for adoptive immunotherapy of human infections or malignancy...
  68. pmc Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways
    Magdalena A Berkowska
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Blood 118:2150-8. 2011
    ..Our findings shed light on human germinal center-dependent and -independent B-cell memory formation and provide new opportunities to study these processes in immunologic diseases...
  69. ncbi The influence of age on T cell generation and TCR diversity
    Keith Naylor
    Department of Medicine, Mayo Clinic and Graduate School, Rochester, MN 55905, USA
    J Immunol 174:7446-52. 2005
    ..The collapse in CD4 T cell diversity during the seventh and eighth decades indicates substantial T cell loss and implies that therapeutic measures to improve vaccine responses will have to include strategies for T cell replenishment...
  70. pmc Memory CD8 T-cell differentiation during viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, G211 Rollins Research Building, 1510 Clifton Rd, Atlanta, GA 30322, USA
    J Virol 78:5535-45. 2004
  71. ncbi T cell- and B cell-independent adaptive immunity mediated by natural killer cells
    Jacqueline G O'Leary
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:507-16. 2006
    ..These observations indicate that natural killer cells can mediate long-lived, antigen-specific adaptive recall responses independent of B cells and T cells...
  72. pmc Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation
    Laura K Mackay
    Department of Microbiology and Immunology, University of Melbourne, Melbourne 3010, Australia
    Proc Natl Acad Sci U S A 109:7037-42. 2012
    ..The results demonstrate that peripheral T(RM) cells can be generated and survive in the absence of local antigen presentation and provide a powerful means of achieving immune protection against peripheral infection...
  73. ncbi Signals required for programming effector and memory development by CD8+ T cells
    Matthew F Mescher
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunol Rev 211:81-92. 2006
    ..Thus, in addition to antigen and costimulation, CD8+ T cells require cytokine signals at distinct stages of the response to be programmed for optimal generation of effector and memory populations...
  74. ncbi Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    Joseph J Mattapallil
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 434:1093-7. 2005
    ..Our findings point to the importance of reducing the cell-associated viral load during acute infection through therapeutic or vaccination strategies...
  75. ncbi The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
    Katja Lüthje
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Nat Immunol 13:491-8. 2012
    ..Thus, we demonstrated that TFH cells were not terminally differentiated but instead retained the flexibility to be recruited into other helper T cell subsets and nonlymphoid tissues...
  76. pmc Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection
    Joshua J Obar
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06030 1319, USA
    Immunity 28:859-69. 2008
    ..Thus, initial endogenous precursor frequencies were surprisingly diverse and not only regulated initial immune response characteristics but also controlled memory CD8+ T cell lineage decisions...
  77. pmc Constitutive activation of Wnt signaling favors generation of memory CD8 T cells
    Dong Mei Zhao
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 184:1191-9. 2010
    ..Thus, constitutive activation of the canonical Wnt pathway favors memory CD8 T cell formation during initial immunization, resulting in enhanced immunity upon second encounter with the same pathogen...
  78. pmc Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells
    Sonia Feau
    Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 12:908-13. 2011
    ..Our findings reconcile contradictory elements implicit in each model noted above by showing that CD4(+) T cells activate APCs through a CD40L-dependent mechanism to enable autocrine production of IL-2 in CD8(+) memory T cells...
  79. pmc Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1
    Xinyuan Zhou
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Immunity 33:229-40. 2010
    ..Our studies thus identify TCF-1 as a critical player in a transcriptional program that regulates memory CD8 differentiation and longevity...
  80. pmc Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein
    Juliana Falivene
    Centro Nacional de Referencia para el SIDA, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 7:e32220. 2012
    ..The aim of this study was to evaluate cellular immune responses (CIR) induced by an IL-18 binding protein gene (C12L) deleted vector (MVAΔC12L)...
  81. pmc Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria
    Michael Walther
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS Pathog 5:e1000364. 2009
    ..These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation...
  82. ncbi Maintaining protection against invasive bacteria with protein-polysaccharide conjugate vaccines
    Andrew J Pollard
    Department of Paediatrics, University of Oxford, Level 2, Children s Hospital, Oxford, UK
    Nat Rev Immunol 9:213-20. 2009
    ..In this Science and Society article, we describe how vaccine-induced immunity wanes rapidly after vaccination in early childhood and argue that strategies that sustain protection in the population must be considered...
  83. ncbi CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    J Immunol 177:5290-5. 2006
    ..These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function...
  84. pmc Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses
    Silke Paust
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1127-35. 2010
    ..Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6...
  85. pmc Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche
    Arnob Banerjee
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 185:4988-92. 2010
    ....
  86. pmc Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    M V Dhodapkar
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021, USA
    J Exp Med 193:233-8. 2001
    ..These data demonstrate the feasibility of antigen-specific inhibition of effector T cell function in vivo in humans and urge caution with the use of immature DCs when trying to enhance tumor or microbial immunity...
  87. pmc Diversity in T cell memory: an embarrassment of riches
    Stephen C Jameson
    Department of Laboratory Medicine and Pathology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunity 31:859-71. 2009
    ..In this review, we focus on the generation, maintenance, and function of memory T cells, with a special emphasis on the increasing evidence for great diversity among functional memory T cell subsets...
  88. ncbi Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 31:283-95. 2009
    ..This study identifies Blimp-1 as a master regulator of the terminal differentiation of CD8(+) effector T cells and uncovers a conservation of the pathways that regulate the terminal differentiation of T and B cells...
  89. pmc Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations
    Natalie E R Beveridge
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK
    Eur J Immunol 37:3089-100. 2007
    ..Overall, these data strongly support the use of MVA85A in humans as a boosting agent to expand polyfunctional M.tb-specific CD4(+) T cells capable of significant secondary responses...
  90. ncbi Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma
    V P Badovinac
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    Science 290:1354-8. 2000
    ..Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules...
  91. pmc Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory
    Pujya Agarwal
    Center for Immunology and Department of Laboratory, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:1695-704. 2009
    ....
  92. ncbi Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells
    Vanessa L Bryant
    Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    J Immunol 179:8180-90. 2007
    ..These findings suggest that IL-21 produced by TFH cells during the primary as well as the subsequent responses to T cell-dependent Ag makes a major contribution to eliciting and maintaining long-lived humoral immunity...
  93. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
    ..These findings establish that Peyer's patch dendritic cells imprint gut-homing specificity on T cells, and thus license effector/memory cells to access anatomical sites most likely to contain their cognate antigen...
  94. ncbi The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion
    I Gramaglia
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 165:3043-50. 2000
    ..In this way, OX40 signals promote survival of greater numbers of T cells with time and control the size of the memory T cell pool...
  95. pmc Validation of serological correlate of protection for meningococcal C conjugate vaccine by using efficacy estimates from postlicensure surveillance in England
    Nick Andrews
    Immunisation Division, PHLS Communicable Disease Surveillance Centre, London NW9 5EQ, United Kingdom
    Clin Diagn Lab Immunol 10:780-6. 2003
    ..with the MCC vaccine were used, all rSBA cutoffs significantly underestimated efficacy, suggesting that continuing protection is less dependent on the SBA level at the time of exposure but is more reliant on immunologic memory.
  96. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
    ..These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection...
  97. pmc Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection
    Afam Okoye
    Vaccine and Gene Therapy Institute, Department of Pathology, and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 204:2171-85. 2007
    ....
  98. pmc From vaccines to memory and back
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Immunity 33:451-63. 2010
    ..Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells-a journey from vaccines to memory and back...
  99. ncbi A direct estimate of the human alphabeta T cell receptor diversity
    T P Arstila
    Unité de Biologie Moléculaire du Gène, INSERM U277, Institut Pasteur, 75724 Paris Cedex 15, France
    Science 286:958-61. 1999
    ..Thus, the naïve repertoire is highly diverse, whereas the memory compartment, here one-third of the T cell population, contributes less than 1 percent of the total diversity...
  100. pmc Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    Andrew W Sylwester
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon Health and Science University, Beaverton, 97006, USA
    J Exp Med 202:673-85. 2005
    ..These data provide the first glimpse of the total human T cell response to a complex infectious agent and will provide insight into the rules governing immunodominance and cross-reactivity in complex viral infections of humans...
  101. ncbi CD8 T cell dysfunction during chronic viral infection
    Haina Shin
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Immunol 19:408-15. 2007
    ..In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development...

Research Grants71

  1. VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGED
    Rafi Ahmed; Fiscal Year: 2013
    ..the innate responses, to the peak effector T and B cell responses, to the development and maintenance of immunologic memory, (ii) To understand how a successful vaccine works, and to use this knowledge for designing strategies for ..
  2. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ....
  3. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..In order to understand the cellular and molecular mechanisms that establish immunologic memory, we have chosen both in vitro and in vivo models that should promote both short and long-term immune ..
  4. Regulation of Natural Killer T cell maturation, homeostasis and activation
    LOUISE M D'CRUZ; Fiscal Year: 2012
    ....
  5. Novel Nanopolymers to Inhibit Angiogenesis and Increase the Anti-tumor Immunity
    Manuel L Penichet; Fiscal Year: 2013
    ..A novel nanobiopolymer-based therapy against HER2/neu expressing cancer cells with sufficient capacity to inhibit angiogenesis and orchestrate an anti-tumor immune response should make a significant clinical impact. ..
  6. Flexibility and Commitment in Post-Effector Cd4 Lymphocytes
    Mark R Boothby; Fiscal Year: 2013
    ..Antigenic experience is central to the diverse processes involved in immunologic memory. Memory is essential for the efficacy of vaccines, the most cost-effective of medical interventions and a ..
  7. Tracking anti-fungal CD4+ T cells in vivo
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..The results will be broadly significant and impactful for those working in Mycology &Immunology. ..
  8. Roles of rictor in mTOR signaling, differentiation &immune memory via Akt &PKC
    Mark R Boothby; Fiscal Year: 2013
    ....
  9. Phase I Trial with Two HER-2 B Cell Epitope Vaccine in Patients with Solid Tumors
    PRAVIN T P contact KAUMAYA; Fiscal Year: 2010
    ..to efficiently recognize and kill tumor cells could be highly significant because of the generation of immunologic memory induced by vaccination...
  10. CD19 Tyrosine-mediated Signal Transduction in vivo
    Louis B Justement; Fiscal Year: 2012
    ..This project will use CD19, a protein expressed on B lymphocytes that is required for both types of response, as a tool to investigate the functions of B cells in the marginal zone and in germinal centers in vivo. ..
  11. Nanocapsule-mediated topical delivery of VLP-generating Dengue DNA vaccine
    Gretchen M Unger; Fiscal Year: 2013
    ..We will also conduct manufacturing scale-up and other tasks necessary to progress to IND submission and human clinical trials. ..
  12. Gene Expression Biomarkers for Diagnosis of Lyme Disease
    IRA S SCHWARTZ; Fiscal Year: 2012
    ..Once identified, this subset of classifier genes could be employed as the basis for development of a sensitive and specific gene-based diagnostic test for active B. burgdorferi infection. ..
  13. Effect of breast feeding on immunologic priming in young infants.
    John W Sleasman; Fiscal Year: 2013
    ..immunity among infants wanes after initial immunization and multiple boosters are necessary to establish immunologic memory. Compared to formula feeding, infants who are breast fed have improved duration and magnitude of vaccine ..
  14. Enhancing dendritic cell migration to drive potent anti-tumor immune responses
    Kristen Batich; Fiscal Year: 2013
    ..Eliciting the mechanisms by which immunologic memory responses drive DC lymph node homing addresses a critical immunobiologic question and provides translatable ..
  15. Mechanisms of humoral immunity development and function to the smallpox vaccine
    SHANE P CROTTY; Fiscal Year: 2013
    ..We study mechanisms of humoral immunity development and function to the smallpox vaccine virus to understand this gold standard of human vaccine efficacy. ..
  16. TRAIL-expressing Recombinant Adenovirus Based Immunotherapy for RCC
    Thomas S Griffith; Fiscal Year: 2013
    ..challenge of Renca cells, but not MHC-matched prostate tumor cells, showing the existence of tumor-specific immunologic memory. While the effects of CD4+ cell depletion were striking, survival did not reach 100%, suggesting the ..
  17. Investigation of the characteristics and persistence of memory B cells following
    Jiraprapa Wipasa; Fiscal Year: 2012
    ..This work is of clear relevance to development and evaluation of effective malaria vaccines which would be of major health benefit to the more than 3 billion people at risk of malaria infection, worldwide. ..
  18. Mutations, Malignancy and Memory - Antibodies and Immunity
    JAMES WAVELL AIKEN; Fiscal Year: 2012
    ....
  19. Mechanisms of Immune Memory Regulation by PD-1
    Surojit Sarkar; Fiscal Year: 2013
    ..We have shown that quantitative and qualitative properties of immunologic memory are decided early after infection or immunization, and that the duration of antigen is a key determinant...
  20. Development and Maintenance of Memory CD8 T Cells
    Jianzhu Chen; Fiscal Year: 2010
    ....
  21. Generation and Function of NK Cell Memory
    Ulrich H von Andrian; Fiscal Year: 2013
    ..It is hoped that the mechanistic insights gained from these highly interactive and synergistic experiments will lead to new, evidence-based and knowledge-driven development strategies for anti-viral vaccines. ..
  22. Anti-viral immune responses in lymph node
    Ulrich H von Andrian; Fiscal Year: 2012
    ..It is hoped that the mechanistic insights gained from these highly interactive and synergistic experiments will lead to new, evidence-based and knowledge-driven development strategies for anti-viral vaccines. ..
  23. A New Genetic Tool for Lineage Tracing of Mitotic Cells in Mice
    Yuan Zhuang; Fiscal Year: 2011
    ..The outcome will impact our understanding of immune memory and stem cell behaviors. ..
  24. Selective Delivery of a novel bacterial adjuvant for multipurpose vaccination
    GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2013
    ....
  25. IL-12 AS AN IMMUNOPOTENTIATOR IN LEISHMANIASIS
    Phillip A Scott; Fiscal Year: 2013
    ..Overall, the experiments described in this proposal will determine what type of immunologic memory can be induced in leishmaniasis, which will provide direction for the field in establishing what are ..
  26. HERPESVIRUSES AS VACCINE VECTORS FOR AIDS
    David M Knipe; Fiscal Year: 2010
    ..This project will examine the nature of immunologic memory induced by different recombinant HSV immunization protocols and determine how it relates to protection ..
  27. Loading Skin-Derived Antigen on Dendritic Cells in Vivo for T Responses in Vitro
    James J Campbell; Fiscal Year: 2010
    ..Our project will help us to understand how immune cells develop the ability to enter the skin to repulse disease-causing agents. ..
  28. Transcriptional regulation of immunological memory
    Laura Shaw; Fiscal Year: 2013
    ....
  29. Cancer Immunotherapy by Targeting A2 Adenosine Receptor
    Michail Sitkovsky; Fiscal Year: 2013
    ..This, in turn, will provide superior design of anti-hypoxia-A2AR-adenosinergic clinical protocols. ..
  30. Dendritic Cell-Associated C-Type Lectins
    Edward A Clark; Fiscal Year: 2013
    ..These studies may lead to new insights into how to induce and regulate immunologic memory, and in particular humoral immunity...
  31. The NF-kB signaling system as a regulator of B-cell activation
    Alexander Hoffmann; Fiscal Year: 2013
    ....
  32. A New Genetic Tool for Lineage Tracing of Mitotic Cells in Mice
    Yuan Zhuang; Fiscal Year: 2012
    ..We anticipate a broad application of this marking system in the fields such as tissue regeneration, aging, and immunological memory. ..
  33. REGULATION OF CR2/CD21 EXPRESSION AND ACTIVATION
    JOHN WEIS; Fiscal Year: 2012
    ..The CD21 proteins straddle the fields of acquired and innate immune responses such that their manipulation could influence immediate responses to an infection as well as the more long term consequences of immunologic memory.
  34. Cytokine regulation of memory CD8 T cell responses
    Kimberly D Klonowski; Fiscal Year: 2013
    ..Understanding and exploiting the factors regulating memory is paramount to developing vaccines with improved efficacy. ..
  35. Visualization and analysis of dendritic cell function in zebrafish
    KANAKO LEWIS; Fiscal Year: 2013
    ....
  36. Elucidating functional properties of memory B cells
    MARY TOMAYKO; Fiscal Year: 2012
    ..These proposed studies will help elucidate how "memory" functions in order to better understand natural immunity and improve vaccine design. ..
  37. Control of Effector and Memory T Cell Development by Inflammatory Signals
    Susan M Kaech; Fiscal Year: 2013
    ..abstract_text> ..
  38. Discovery and Validation of Tumor Immunoevasion Mechanisms
    DAVID ANDREW LARGAESPADA; Fiscal Year: 2013
    ..IMPACT: The identification of integrated pathways that tumors require to escape immune responses in order to thrive, which will ultimately lead to the development of drugs that increase the efficacy of cancer immunotherapy. ..
  39. Mechanisms of Innate Immune Memory
    MEGAN ANNE COOPER; Fiscal Year: 2013
    ..One classical distinction between innate and adaptive immunity is the restriction of immunologic memory to adaptive T and B lymphocytes...
  40. Multi-peptide Vaccine Administered with Cyclophosphamide for High-risk Melanoma
    CRAIG LEE SLINGLUFF; Fiscal Year: 2010
    ..CD4 responses appear to be critical for immunologic memory, and for dendritic cell activation...
  41. Enhancing T-Cell Responses with the Glutathione Mimetic NOV-002 in Breast Cancer
    ALBERTO JOSE MONTERO; Fiscal Year: 2013
    ..being proposed: 1) Assess the impact of NOV-002 on T cells, and its effect on the generation of long lasting immunologic memory;2) Evaluate whether enhancement of T-dependent immune responses by NOV-002 is due to decreased suppressive ..
  42. A Novel Approach to RSV Vaccination
    Joan E Durbin; Fiscal Year: 2013
    ..4) Large scale production of genetically stable NDV-F under GMP conditions. ..
  43. Generation of long-term B cell memory and antibody responses to viral infections
    SHANE P CROTTY; Fiscal Year: 2012
    ..abstract_text> ..
  44. Inducing antigen specific B cell tolerance
    James C Paulson; Fiscal Year: 2013
    ....
  45. Metabolic Regulation of CD8 T Cell Memory Development
    Erika L Pearce; Fiscal Year: 2013
    ....
  46. Murine Memory B Cell Development and Function
    Mark J Shlomchik; Fiscal Year: 2013
    ..Together, these experiments should provide significant advances in an important but relatively understudied area: the origins and function of murine memory B cells. ..
  47. Shaping Antiviral Immunity by the Inflammatory, Regulatory and Tissue Environment
    E John Wherry; Fiscal Year: 2013
    ..Our goal is to define how unrelated infections impact immunological memory in hopes to improve vaccines. ..
  48. Infection and CD8 T Cell Memory: Development, Maintenance and Plasticity
    Claudia Dominguez; Fiscal Year: 2011
    ..Specific Aim 3: To determine if the transcription factor ZEB, a candidate target of T-bet, co-regulates the terminal differentiation of CD8 T cells. ..
  49. Regulation of CD8 immunity to intracellular infections
    Ananda W Goldrath; Fiscal Year: 2013
    ..Furthermore, we will study the clinical relevance of pharmacologic stabilization of HIF, a molecule targeted in numerous disease contexts, to CD8+ T cell function. ..
  50. Exploiting the Unique T Cell Response to CMV for a Cancer Vaccine
    Ann B Hill; Fiscal Year: 2010
    ..Our goal is to harness this potent immune response elicited by CMV to test use as an effective tumor vaccine. A safe vaccine vector that is unable to replicate will be generated for this purpose. ..
  51. MEMORY T CELLS IN EAE
    Samia J Khoury; Fiscal Year: 2012
    ..is the fact that the adaptive immune response, by virtue of evolutionary design, is destined to generate immunologic memory;and initial data suggest that memory T cells tend to be resistant to induction of tolerance...
  52. Mechanisms of CD4 T cell memory development during viral and bacterial infections
    HEATHER DIANE MARSHALL; Fiscal Year: 2013
    ..Thus, this work wil help to define the mechanisms involved anti-viral CD4 T cell differentiation and memory development in order to develop more eficacious vaccines. ..
  53. T CELL MEMORY TO VIRUSES
    Rafi Ahmed; Fiscal Year: 2013
    ..Uncovering the mechanism will not only give us a better understanding of memory T cell development but also for establishing a new and more specific molecular target for vaccine development.) ..
  54. ApoVax-SVN as a Novel Vaccine for Cancer Immunotherapy
    Haval Shirwan; Fiscal Year: 2007
    ..ApoImmune's novel immune system-based therapy, ApoVax104 vaccine, is a new, innovative approach to treating cancer and malignant neoplastic diseases. [unreadable] [unreadable] [unreadable]..
  55. Role of transcription coactivator OCA-B in gene poising and immunological memory.
    Dean Tantin; Fiscal Year: 2013
    ..Specific Aim 2: Identify the target genes that utilize OCA-B to prevent stable repression. Specific Aim 3: Determine the in vivo consequences of OCA-B anti-repression. ..
  56. NK cell mediated immune pressure in HIV-1 infection
    Marcus Altfeld; Fiscal Year: 2013
    ....
  57. Listeria-induced cytosolic response and host immunity
    KRISTINA ANN ARCHER; Fiscal Year: 2010
    ..This work will contribute to the understanding of how inflammation generates long-term memory and may reveal new insights on methods to develop safe and effective vaccines. ..
  58. Immunological memory to malaria liver stage antigens
    James Kazura; Fiscal Year: 2006
    ..Ongoing studies in Papua New Guinea indicate this area is well suited for examination of immunologic memory in malaria because HLA heterogeneity is limited (HLA-A* 1101 frequency = 67 percent and peptides of vaccine ..
  59. BRUCELLA VACCINE FOR BIOTERRORISM
    Gary Splitter; Fiscal Year: 2003
    ..However, a Brucella memory response is a likely foundation for successful vaccination, and immunologic memory is hypothesized to play a key role in protection...
  60. Potentiating an anthrax DNA vaccine with electroporation
    Brian Livingston; Fiscal Year: 2005
    ..These will include biodistribution and integration studies in rats and a toxicological evaluation in rabbits. Following the completion of the studies, Ichor will initiate pre- IND discussions with the FDA. ..
  61. MULTI-EPITOPE MELANOMA VACCINES FOR CD4 AND CD8 T-CELLS
    Craig Slingluff; Fiscal Year: 2009
    ..CD4 responses appear to be critical for immunologic memory, and for dendritic cell activation...
  62. DEVELOPMENT AND PERSISTENCE OF MEMORY T LYMPHOCYTES
    Philip Ashton Rickardt; Fiscal Year: 2009
    ..The research proposed will lead to improved in vaccination through the induction of potent T cell memory, a goal that up until now has remained elusive for many viruses and cancers. ..
  63. Determinants of antibody-based host resistance against Pneumocystis carinii
    REKHA RAPAKA; Fiscal Year: 2009
    ..Specific Aim I will evaluate the generation of humoral-mediated immunologic memory against PC through characterization of the kinetics of antibody recall responses in the presence or absence ..
  64. ANTIGEN-INDUCED B LYMPHOCYTE DEVELOPMENT
    Douglas Fearon; Fiscal Year: 2006
    ..abstract_text> ..
  65. THE SECRETORY IGA SYSTEM OF THE EYE
    David Sullivan; Fiscal Year: 1993
    ....
  66. Chimeric CD80-SA as a Novel Cancer Vaccine
    Rolf Huseby; Fiscal Year: 2006
    ..The long term success of this project may allow for the development of ApoVax(tm) as a multi-million dollar cancer vaccine product and improvement in the longevity and quality of life for millions of cancer patients. ..
  67. MUCOSAL T-CELLS IN EARLY&LATE PEDIATRIC CROHN'S DISEASE
    Subra Kugathasan; Fiscal Year: 2005
    ..133: 675- 81, 1998). Recent flow cytometric analysis of mucosal T-cell phenotype has shown that markers of immunologic memory (CD45RA, CD45RO) and homing (L- selectin) differentiate "early" and "late" phases of chronic inflammation in ..
  68. Assessment of Smallpox Specific Immune Responses
    Thomas Denny; Fiscal Year: 2003
    ..Hypothesis: Response level and/or frequency of CD4 or CD8 cells to various immunodominant viral epitopes will change with age, time since last vaccination or presence of disease (e.g, HIV)...
  69. TARGETED DELIVERY OF ANTIGENS TO INDUCE HIV IMMUNITY
    M Jabbar; Fiscal Year: 2002
    ..The success of this novel vaccine approach will have major implications in the development of DNA vaccines having the ability to induce effective B and T cell responses in animals. ..
  70. Multi-Antigen Vaccines for Breast Cancer
    MARY DISIS; Fiscal Year: 2007
    ..Finally, the clinical endpoint of any vaccine is the generation of immunologic memory; a lifelong endogenous immune response that would prevent the growth of disease at any distant time point ..
  71. CANCER CHEMOTHERAPY AND IMMUNOLOGIC EFFECTS
    Enrico Mihich; Fiscal Year: 2001
    ..abstract_text> ..