immunocompromised host


Summary: A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.

Top Publications

  1. pmc Influenza in immunosuppressed populations: a review of infection frequency, morbidity, mortality, and vaccine responses
    Ken M Kunisaki
    Pulmonary Section, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Lancet Infect Dis 9:493-504. 2009
  2. ncbi Infection in solid-organ transplant recipients
    Jay A Fishman
    Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 357:2601-14. 2007
  3. ncbi European guidelines for antifungal management in leukemia and hematopoietic stem cell transplant recipients: summary of the ECIL 3--2009 update
    J Maertens
    Department of Hematology, Leukemia and Stem Cell Transplantation Unit, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium
    Bone Marrow Transplant 46:709-18. 2011
  4. ncbi Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study Group
    S Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
    Clin Infect Dis 31:499-508. 2000
  5. ncbi Definitions of cytomegalovirus infection and disease in transplant recipients
    Per Ljungman
    Department of Hematology, Huddinge University Hospital, Karolinska Institutet, SE 14186 Stockholm, Sweden
    Clin Infect Dis 34:1094-7. 2002
  6. ncbi Rhodococcus equi: an emerging pathogen
    David M Weinstock
    Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Infect Dis 34:1379-85. 2002
  7. ncbi Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients
    Janet A Englund
    Children s Hospital and Regional Medical Center, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98105, USA
    Ann Intern Med 144:344-9. 2006
  8. ncbi Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus
    S Ascioglu
    Clin Infect Dis 34:7-14. 2002
  9. ncbi Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders
    Muhammed Babakir-Mina
    Laboratory of Molecular Virology, University Hospital Tor Vergata, Viale Oxford, Rome, Italy
    J Med Virol 81:1668-73. 2009
  10. ncbi Infection of immunocompromised patients by avian H9N2 influenza A virus
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Infect 62:394-9. 2011

Detail Information

Publications334 found, 100 shown here

  1. pmc Influenza in immunosuppressed populations: a review of infection frequency, morbidity, mortality, and vaccine responses
    Ken M Kunisaki
    Pulmonary Section, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Lancet Infect Dis 9:493-504. 2009
    ..Randomised clinical trial data were limited to one study of HIV-infected patients with high vaccine efficacy. Better trial data would inform vaccination recommendations on the basis of efficacy and cost in these at-risk populations...
  2. ncbi Infection in solid-organ transplant recipients
    Jay A Fishman
    Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 357:2601-14. 2007
  3. ncbi European guidelines for antifungal management in leukemia and hematopoietic stem cell transplant recipients: summary of the ECIL 3--2009 update
    J Maertens
    Department of Hematology, Leukemia and Stem Cell Transplantation Unit, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium
    Bone Marrow Transplant 46:709-18. 2011
    ..the European Organization for Treatment and Research of Cancer, the European Leukemia Net and the Immunocompromised Host Society created the European Conference on Infections in Leukemia (ECIL)...
  4. ncbi Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study Group
    S Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
    Clin Infect Dis 31:499-508. 2000
    ..Resistance to antifungal drugs was uncommon. The epidemiology of CNVN infection has changed substantially. Clinical manifestations of disease are influenced more strongly by host immune status than by cryptococcal variety...
  5. ncbi Definitions of cytomegalovirus infection and disease in transplant recipients
    Per Ljungman
    Department of Hematology, Huddinge University Hospital, Karolinska Institutet, SE 14186 Stockholm, Sweden
    Clin Infect Dis 34:1094-7. 2002
    ..This study seeks to update the definitions of CMV on the basis of recent developments in diagnostic techniques, as well as to add to these definitions the concept of indirect effects caused by CMV...
  6. ncbi Rhodococcus equi: an emerging pathogen
    David M Weinstock
    Department of Medicine, Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Infect Dis 34:1379-85. 2002
    ..Treatment is often prolonged, and relapses at distant sites are common. This article summarizes the history, diagnosis, clinical features, and treatment of infection with this emerging pathogen...
  7. ncbi Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients
    Janet A Englund
    Children s Hospital and Regional Medical Center, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington 98105, USA
    Ann Intern Med 144:344-9. 2006
    ..Human metapneumovirus (hMPV), a recently discovered respiratory virus, is associated with clinical disease in young and elderly persons...
  8. ncbi Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus
    S Ascioglu
    Clin Infect Dis 34:7-14. 2002
    ..quot; The definitions are intended for use in the context of clinical and/or epidemiological research, not for clinical decision making...
  9. ncbi Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders
    Muhammed Babakir-Mina
    Laboratory of Molecular Virology, University Hospital Tor Vergata, Viale Oxford, Rome, Italy
    J Med Virol 81:1668-73. 2009
    ..The novel polyomaviruses KI and WU may have a pathogenic role in immunocompromised patients...
  10. ncbi Infection of immunocompromised patients by avian H9N2 influenza A virus
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Infect 62:394-9. 2011
    ..It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted...
  11. ncbi Intestinal protozoan infections in the immunocompromised host
    Luis A Marcos
    Institute of Tropical Medicine Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Curr Opin Infect Dis 26:295-301. 2013
    ..However, pathogenesis of infection is still poorly understood, diagnostic tests remain insensitive, and management continues to pose a challenge...
  12. pmc The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts
    Sarah P Georgiadou
    Infectious Diseases Unit, Pathophysiology Department, Laikon General Hospital and Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Clin Infect Dis 52:1144-55. 2011
    ..This review aims to evaluate the diagnostic value of the halo sign and reversed halo sign in immunocompromised hosts and describes the wide spectrum of diseases associated with them...
  13. ncbi Evolving health effects of Pneumocystis: one hundred years of progress in diagnosis and treatment
    Joseph A Kovacs
    Critical Care Medicine Department, National Institutes of Health, Bldg 10, Room 2C145, MSC 1662, Bethesda, MD 20892 1662, USA
    JAMA 301:2578-85. 2009
    ..Trimethoprim-sulfamethoxazole is the preferred drug regimen for both treatment and prevention of PCP, although a number of alternatives are also available. Corticosteroids are an important adjunct for hypoxemic patients...
  14. ncbi Prolonged hospital and community-based listeriosis outbreak caused by ready-to-eat scalded sausages
    C H Winter
    Baden Württemberg State Health Office, District Government Stuttgart, Germany
    J Hosp Infect 73:121-8. 2009
    ..Hospital food suppliers should guarantee the absence of L. monocytogenes in ready-to-eat meat products, controlled through optimised quality assurance...
  15. ncbi Human cytomegalovirus-specific CD4+ and CD8+ T cell responses in primary infection of the immunocompetent and the immunocompromised host
    Daniele Lilleri
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Clin Immunol 131:395-403. 2009
    ..Thus, the development of cell-mediated immune response in primary HCMV infection may be missed when looking at pp65 and IE-1 peptide-stimulated T-cells only...
  16. ncbi Invasive mycoses: strategies for effective management
    Dimitrios P Kontoyiannis
    Division of Internal Medicine, Department of Infectious Diseases Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Med 125:S25-38. 2012
    ..This article discusses strategies for the effective management of invasive mycoses, with a particular focus on antifungal hepatotoxicity...
  17. pmc Role for tumor necrosis factor-α in JC virus reactivation and progressive multifocal leukoencephalopathy
    Hassen S Wollebo
    Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, USA
    J Neuroimmunol 233:46-53. 2011
    ..Immunohistochemistry of HIV+/PML revealed robust labeling for TNF-α and TNFR-1. These data suggest TNF-α stimulation of κB may contribute to JCV reactivation in HIV+/PML...
  18. ncbi Disseminated Bartonella infection following liver transplantation
    Hugo Bonatti
    Transplant Center, Mayo Clinic, Jacksonville, FL, USA
    Transpl Int 19:683-7. 2006
  19. ncbi Genetic identification of intestinal microsporidia species in immunocompromised patients in Tunisia
    Najla Chabchoub
    Laboratoire de Recherche 05 SP 03, Laboratoire de Parasitologie, Institut Pasteur de Tunis, Tunis, Tunisia
    Am J Trop Med Hyg 80:24-7. 2009
    ..Systematic use of such sensitive and discriminative molecular tools will contribute to determining the true prevalence of microsporidiosis in Tunisia and to better management of infected immunocompromised subjects...
  20. ncbi Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, Aviano, Italy
    Am J Hematol 86:170-9. 2011
    ..Refractory CHL, a clinical condition that may occur throughout the entire spectrum of CHL, is discussed separately...
  21. ncbi First case in Italy of acquired resistance to oseltamivir in an immunocompromised patient with influenza A/H1N1v infection
    Giulia Campanini
    Molecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    J Clin Virol 48:220-2. 2010
    ..No other drug-resistant influenza A/H1N1v virus strains have been detected in Italy (up to the end of November 2009) since the first case of the novel A/H1N1v virus was identified in the country (May 2009)...
  22. pmc Respiratory tract reinfections by the new human Metapneumovirus in an immunocompromised child
    Gilles Pelletier
    Centre Hospitalier Universitaire de Quebec and Laval University, Quebec, Canada
    Emerg Infect Dis 8:976-8. 2002
    ..We report the case of a young, immunocompromised child who had severe lower respiratory tract infections during two consecutive winter seasons caused by genetically distinct HMPV strains...
  23. pmc Seroprevalence of trichodysplasia spinulosa-associated polyomavirus
    Els van der Meijden
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Emerg Infect Dis 17:1355-63. 2011
    ..In 80 renal transplant patients, seroprevalence was 89%. Infection with the new TSV polyomavirus is common and occurs primarily at a young age...
  24. ncbi Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients
    Maurizia Debiaggi
    Department of Morphological and Clinical Sciences, Section of Microbiology, University of Pavia, Pavia, Italy
    J Med Virol 82:153-6. 2010
    ..The results suggest that WU/KIPyVs have a limited circulation in Italy and a low pathogenic potential in young children. Brief and asymptomatic infection can occur in hematopoietic transplant recipients...
  25. ncbi Progressive multifocal leukoencephalopathy: a national estimate of frequency in systemic lupus erythematosus and other rheumatic diseases
    Eamonn S Molloy
    Fasenmeyer Center for Clinical Immunology, Department of Rheumatic and Immunology Diseases, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arthritis Rheum 60:3761-5. 2009
    ..The aim of this study was to generate a national estimate of the frequency of PML among patients with rheumatic diseases...
  26. pmc Infections caused by Scedosporium spp
    Karoll J Cortez
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Microbiol Rev 21:157-97. 2008
    ..By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans...
  27. pmc Clinical significance of enteric protozoa in the immunosuppressed human population
    D Stark
    Department of Microbiology, St Vincent s Hospital, Darlinghurst 2010, NSW, Australia
    Clin Microbiol Rev 22:634-50. 2009
  28. pmc H275Y mutant pandemic (H1N1) 2009 virus in immunocompromised patients
    Christian Renaud
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Emerg Infect Dis 17:653-60; quiz 765. 2011
    ..Emergence of oseltamivir resistance is frequent in immunocompromised patients infected with pandemic (H1N1) 2009 virus and can be associated with a wide range of clinical disease and viral kinetics...
  29. ncbi Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients
    Maurizia Debiaggi
    Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, Sezione di Microbiologia, Universita di Pavia, via Brambilla, 74, 27100, Pavia, Italy
    J Infect Dis 194:474-8. 2006
    ..The data indicate that HSCT recipients may frequently develop symptomless hMPV infection...
  30. ncbi Rhodococcus equi infection
    Alexandra V Yamshchikov
    Emory University School of Medicine, Division of Infectious Diseases, Decatur, GA 30030, USA
    Lancet Infect Dis 10:350-9. 2010
    ..We review the pathogenesis and clinical characteristics of infections with Rhodococcus spp, and discuss approaches to treatment of this disease entity in populations of patients who are immunocompromised...
  31. ncbi Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group
    T F Patterson
    Division of Infectious Diseases, University of Texas Health Science Center, San Antonio 78284 7881, USA
    Medicine (Baltimore) 79:250-60. 2000
    ..New approaches and new therapies are needed to improve the outcome of invasive aspergillosis in high-risk patients...
  32. pmc Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide-deficient mutant of Cryptococcus neoformans in immunodeficient mice
    Talar B Kechichian
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Infect Immun 75:4792-8. 2007
    ..This study highlights the hypothesis that AMs may exacerbate C. neoformans infection in conditions in which there is severe host immunodeficiency...
  33. ncbi Recurrent bacteremia caused by Rhodococcus equi in a non-neutropenic patient with acute myeloid leukemia in complete remission
    Ana Cid
    Haematology, Infectious Diseases and Microbiology Services, Hospital Universitario La Fe, Av Campanar 21, 46009 Valencia, Spain
    Haematologica 87:ECR03. 2002
  34. ncbi Highly sensitive biosafety model for stem-cell-derived grafts
    B Lawrenz
    Cardion AG, Erkrath, Germany
    Cytotherapy 6:212-22. 2004
    ..Our goal was to establish a highly sensitive animal model for testing the proliferative potential of stem-cell grafts...
  35. ncbi Salmonella infections in immunocompromised adults
    Melita A Gordon
    Division of Gastroenterology, Henry Wellcome Laboratories, Nuffield Building, Crown Street, Liverpool University L69 3GE, UK
    J Infect 56:413-22. 2008
    ..This review will describe the presentation and pathogenesis of NTS in different categories of immunocompromised adults, contrasted to typhoid fever...
  36. pmc Multiplex blood PCR in combination with blood cultures for improvement of microbiological documentation of infection in febrile neutropenia
    F Lamoth
    Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    J Clin Microbiol 48:3510-6. 2010
    ..Technical adjustments may enhance the efficiency of this new molecular tool in this specific setting...
  37. ncbi Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome
    Kent A Sepkowitz
    Memorial Sloan Kettering Cancer Center, New York, NY, 10021, USA
    Clin Infect Dis 34:1098-107. 2002
    ..Reviewed are 4 common opportunistic infections: Pneumocystis carinii pneumonia, cryptococcosis, atypical mycobacterial infection, and cytomegalovirus infection. Emphasized are the important differences among these groups at risk...
  38. ncbi Characterization of multidrug-resistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child
    Mariana Baz
    Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, G1V 4G2, Canada
    Clin Infect Dis 43:1555-61. 2006
    ..Development of influenza drug resistance is an important problem in immunocompromised children that could result in treatment failure and viral transmission to others...
  39. ncbi Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    G Hilbert
    Division of Medical Intensive Care, University Hospital, Bordeaux, France
    N Engl J Med 344:481-7. 2001
    ..Avoiding intubation is a major goal in the management of respiratory failure, particularly in immunosuppressed patients. Nevertheless, there are only limited data on the efficacy of noninvasive ventilation in these high-risk patients...
  40. ncbi Differentiation of human embryonic stem cells after transplantation in immune-deficient mice
    Stefan A Przyborski
    School of Biological and Biomedical Science, University of Durham, South Road, Durham DH1 3LE, UK
    Stem Cells 23:1242-50. 2005
  41. ncbi Nocardiosis: updated clinical review and experience at a tertiary center
    J Ambrosioni
    Division of Infectious Diseases, Faculty of Medicine, University Hospitals of Geneva, 4 rue Gabrielle Perret Gentil, 1211 Geneva 14, Switzerland
    Infection 38:89-97. 2010
    ..We report the epidemiologic characteristics of Nocardia spp. observed in our institution and discuss the risk factors, clinical features, diagnosis, and management of the disease...
  42. pmc A comparative study of Merkel cell, BK and JC polyomavirus infections in renal transplant recipients and healthy subjects
    Mohamed I Husseiny
    Division of Translational Vaccine Research, Department of Virology, Beckman Research Institute of the City of Hope, Duarte, CA 91010 3000, USA
    J Clin Virol 49:137-40. 2010
    ..Merkel cell carcinoma (MCC) is a rare skin cancer associated with immunosuppression and the integration of Merkel cell polyomavirus (MCPyV) DNA into the tumor cell genome. Little is known about the natural history of MCPyV infection...
  43. pmc Human polyomaviruses in children undergoing transplantation, United States, 2008-2010
    Erica A Siebrasse
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Emerg Infect Dis 18:1676-9. 2012
    ..All were detected; several were present in previously unreported specimen types...
  44. ncbi TLR3 essentially promotes protective class I-restricted memory CD8⁺ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients
    Agostinho Carvalho
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, Perugia, Italy
    Blood 119:967-77. 2012
    ..Therefore, TLR3 essentially promotes antifungal memory CD8⁺ T-cell responses and its deficiency is a novel susceptibility factor for aspergillosis in high-risk patients...
  45. ncbi Central nervous system infections in immunocompromised patients: update on diagnostics and therapy
    Martin Schmidt-Hieber
    Medizinische Klinik III, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Leuk Lymphoma 50:24-36. 2009
    ..Additionally, we give an overview on the diagnostics and management of cerebral infections in these patients including evidence evaluation of efficacy of treatment...
  46. ncbi Systemic mycoses in the immunocompromised host: an update in antifungal therapy
    D P Kontoyiannis
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    J Hosp Infect 53:243-58. 2003
    ..Ongoing and future studies will determine their exact role in the management of different mycoses. The acceleration of antifungal drug discovery offers promise for the management of these difficult to treat opportunistic infections...
  47. pmc A cluster of Listeria monocytogenes infections in hospitalized adults
    Ianick Souto Martins
    Faculdade de Medicina, Universidade Federal Fluminense, Niteroi, Brazil
    Am J Infect Control 38:e31-6. 2010
    ..It is believed that most cases of listeriosis are acquired in the community. A cluster of listeriosis in hospitalized patients prompted the present investigation...
  48. pmc Polyomaviruses KI and WU in immunocompromised patients with respiratory disease
    Thomas Mourez
    Laboratory of Microbiology, Saint Louis University Hospital, Paris
    Emerg Infect Dis 15:107-9. 2009
    ..KIPyV was significantly more frequent among human stem cell transplant patients (17.8% vs. 5.1%; p = 0.01)...
  49. pmc Long-term shedding of influenza A virus in stool of immunocompromised child
    Benjamin A Pinsky
    Stanford University, Stanford, California 94305 5324, USA
    Emerg Infect Dis 16:1165-7. 2010
    ..We describe chronic influenza A virus infection in an immunocompromised child who had prolonged shedding of culturable influenza virus in stool...
  50. pmc BK polyomavirus: emerging pathogen
    Shauna M Bennett
    Program in Cellular and Molecular Biology, University of Michigan Medical School, 1150 West Medical Center Drive, 5724 Medical Science II, Ann Arbor, MI 48109 5620, USA
    Microbes Infect 14:672-83. 2012
    ..In this review, we discuss the clinical relevance, effects on the host, virus life cycle, and current treatment protocols...
  51. pmc Usefulness of molecular biology performed with formaldehyde-fixed paraffin embedded tissue for the diagnosis of combined pulmonary invasive mucormycosis and aspergillosis in an immunocompromised patient
    Veronique Hofman
    Laboratory of Clinical and Experimental Pathology, Louis Pasteur Hospital, 30 Avenue de la Voie Romaine, Nice, France
    Diagn Pathol 5:1. 2010
    ..In this regard, it shows that PCR on selected paraffin blocks is a very powerful method for making or confirming the association of different filamentous mycoses and that this method should be made available to pathology laboratories...
  52. ncbi KI polyomavirus detected in respiratory tract specimens from patients in St. Louis, Missouri
    David J Hormozdi
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Pediatr Infect Dis J 29:329-33. 2010
    ..So far, evidence has not supported a link between infections with either virus and respiratory tract disease; however, there has not been a large comparison of KIPyV-infected patients to age-matched patient groups...
  53. pmc Emerging viral infections of the central nervous system: part 2
    Kenneth L Tyler
    Department of Neurology, University of Colorado Denver Health Sciences Center, Aurora, CO 80045, USA
    Arch Neurol 66:1065-74. 2009
  54. pmc WU and KI polyomaviruses in respiratory samples from allogeneic hematopoietic cell transplant recipients
    Jane Kuypers
    University of Washington, Seattle, Washington 98102, USA
    Emerg Infect Dis 18:1580-8. 2012
    ..There were no associations with polyomavirus detection and acute graft versus host disease, cytomegalovirus reactivation, neutropenia, lymphopenia, hospitalization, or death...
  55. pmc Progressive multifocal leukoencephalopathy: clinical and molecular aspects
    Eleonora Tavazzi
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
    Rev Med Virol 22:18-32. 2012
    ..Clinical observations can inform molecular studies of the virus, and likewise, molecular findings concerning the life cycle of the virus can guide the development of novel therapeutic strategies...
  56. pmc Immunogenicity and reactogenicity of 2009 influenza A (H1N1) inactivated monovalent non-adjuvanted vaccine in elderly and immunocompromised patients
    João L Miraglia
    Butantan Institute Clinical Trials Division, Sao Paulo, Brazil
    PLoS ONE 6:e27214. 2011
    ..Immunosuppressed individuals present serious morbidity and mortality from influenza, therefore it is important to understand the safety and immunogenicity of influenza vaccination among them...
  57. ncbi Hepatitis E virus excretion can be prolonged in patients with hematological malignancies
    Suzanne Tavitian
    Service d Hematologie, CHU de Toulouse, Hopital Purpan, Place du Dr Baylac, 31059 Toulouse Cedex, France
    J Clin Virol 49:141-4. 2010
    ..Chronic hepatitis E virus infections have been recently described in solid organ transplant recipients. There is little data on the evolution of hepatitis E in patients immunocompromised for other reasons...
  58. ncbi Human polyomavirus JC reactivation and pathogenetic mechanisms of progressive multifocal leukoencephalopathy and cancer in the era of monoclonal antibody therapies
    A Bellizzi
    Department of Health Sciences and Infectious Diseases, Sapienza University, P le Aldo Moro, 5, 00185 Rome, Italy
    J Neurovirol 18:1-11. 2012
  59. ncbi Study on invasive fungal infections in immunocompromised patients to present a suitable early diagnostic procedure
    Parisa Badiee
    Department of Medical Parasitology and Mycology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
    Int J Infect Dis 13:97-102. 2009
    ..The incidence of invasive fungal infections has increased considerably in recent years. The aim of this study was to present a suitable early diagnostic procedure in immunocompromised patients, using a molecular assay...
  60. pmc Human polyoma viruses and disease with emphasis on clinical BK and JC
    Raghavender Boothpur
    Barnes Jewish Hospital, St Louis, MO, United States
    J Clin Virol 47:306-12. 2010
    ..There are no known effective antiviral agents for any of the polyoma viruses...
  61. pmc Tubulinosema sp. microsporidian myositis in immunosuppressed patient
    Maria M Choudhary
    Cleveland Clinic Foundation, Department of Internal Medicine, 9500 Euclid Foundation, NA10, Cleveland, OH 44195, USA
    Emerg Infect Dis 17:1727-30. 2011
    ..We report an infection by Tubulinosema sp. in an immunosuppressed patient...
  62. ncbi Imaging manifestations of progressive multifocal leukoencephalopathy
    R Shah
    Division of Neuroradiology, Department of Diagnostic Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Clin Radiol 65:431-9. 2010
  63. ncbi Compromised B cell responses to influenza vaccination in HIV-infected individuals
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Infect Dis 191:1442-50. 2005
    ..We assessed the impact of HIV disease on B cell responses to influenza vaccination...
  64. pmc Use of licensed vaccines for active immunization of the immunocompromised host
    L A Pirofski
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Microbiol Rev 11:1-26. 1998
    ..This review suggests that for most vaccines there are little or no efficacy data in those with impaired immunity but their use in this patient group is generally safe...
  65. ncbi Immunogenicity and safety of the 2009 non-adjuvanted influenza A/H1N1 vaccine in a large cohort of autoimmune rheumatic diseases
    Carla G S Saad
    Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo Disciplina de Reumatologia, Sao Paulo, Brazil
    Ann Rheum Dis 70:1068-73. 2011
  66. ncbi Epidemiology, outcomes, and costs of invasive aspergillosis in immunocompromised children in the United States, 2000
    Theoklis E Zaoutis
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 117:e711-6. 2006
    ..IA in adults has been well characterized; however, only a few small studies of IA in children have been reported. Therefore, the objective of this study was to describe the incidence and outcomes of children with IA...
  67. pmc An immunocompromised murine model of chronic Bartonella infection
    Lucius Chiaraviglio
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Pathol 176:2753-63. 2010
    ..We believe that this new model will provide an important new tool for investigation of Bartonella-host interaction...
  68. ncbi Trichodysplasia spinulosa--a rare complication in immunosuppressed patients
    Agnes Schwieger-Briel
    Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada
    Pediatr Dermatol 27:509-13. 2010
    ..Treatment trials included reduction of immunosuppression combined with topical and oral retinoids, topical acyclovir, and oral valganciclovir with limited success...
  69. ncbi Infectious complications of biological therapy
    Nigil Haroon
    Toronto Western Research Institute, University of Toronto, Ontario, Canada
    Curr Opin Rheumatol 21:397-403. 2009
    ..Here we review the latest publications on infectious complications of biological therapy in rheumatic diseases...
  70. ncbi Viral-associated trichodysplasia of immunosuppression: report of a pediatric patient with response to oral valganciclovir
    Taylor Benoit
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, 135 Rutledge Ave, Charleston, SC 29425, USA
    Arch Dermatol 146:871-4. 2010
    ..It is associated with distinctive histologic features such as dilated anagen hair follicles, absent hair papillae, and abrupt cornification of the inner root sheath...
  71. ncbi Performance of tests for latent tuberculosis in different groups of immunocompromised patients
    Luca Richeldi
    Section of Respiratory Diseases, Department of Oncology, Hematology and Respiratory Diseases, University of Modena and Reggio Emilia, Italy
    Chest 136:198-204. 2009
  72. pmc The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia
    Jean Pierre Van Geertruyden
    Unit International Health, Epidemiology and Social Medicine, Antwerp University, Belgium
    Malar J 8:258. 2009
    ..This study reports the impact of HIV-1 infection and other variables on the level of malaria humeral immunity in adults with clinical malaria and whether humeral immune suppression was a risk factor for treatment failure...
  73. pmc Rapid selection of a transmissible multidrug-resistant influenza A/H3N2 virus in an immunocompromised host
    Matthew J Memoli
    Respiratory Virus Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MSC 3203 33 North Dr, Bethesda, MD 20892 3203, USA
    J Infect Dis 201:1397-403. 2010
    ..Antigenic drift and genetic variations during prolonged influenza infection have been demonstrated. In this report we describe a multidrug-resistant H3N2 influenza virus isolated from an immunocompromised patient after 5 days of therapy...
  74. ncbi A double-blind, randomized, controlled trial of amphotericin B colloidal dispersion versus amphotericin B for treatment of invasive aspergillosis in immunocompromised patients
    Raleigh Bowden
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Clin Infect Dis 35:359-66. 2002
    ..However, infusion-related chills and fever occurred more frequently in patients receiving ABCD than in those receiving AmB...
  75. ncbi Functional analysis of polyomavirus BK non-coding control region quasispecies from kidney transplant recipients
    Gunn Hege Olsen
    Department of Microbiology and Virology, Institute for Medical Biology, University of Tromsø, Tromsø N 9038, Norway
    J Med Virol 81:1959-67. 2009
  76. ncbi Aspergillus fumigatus: contours of an opportunistic human pathogen
    Allison McCormick
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munich, Germany
    Cell Microbiol 12:1535-43. 2010
    ..fumigatus that are relevant during infection and may distinguish it from non-pathogenic Aspergillus species and (ii) interactions of the pathogen with the innate and adaptive immune systems...
  77. ncbi Sepsis associated with immunosuppressive medications: an evidence-based review
    Juan C Gea-Banacloche
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 32:S578-90. 2004
  78. ncbi A comparative study of clinical manifestations caused by tuberculosis in immunocompromised and non-immunocompromised patients
    Changzhou Shao
    Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Chin Med J (Engl) 116:1717-22. 2003
    ..To characterize the differences between clinical manifestations in immunocompromised patients (ICPs) and non-immunocompromised patients (non-ICPs) with tuberculosis...
  79. ncbi Vibrio vulnificus infection: diagnosis and treatment
    Michael H Bross
    Corpus Christi Family Practice Residency Program, Corpus Christi, Texas 78405, USA
    Am Fam Physician 76:539-44. 2007
    ..Physician awareness of risk factors for V. vulnificus infection combined with prompt diagnosis and treatment can significantly improve patient outcomes. (Am Fam Physic..
  80. pmc Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts
    Rutger Jan Swijnenburg
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:12991-6. 2008
    ..This process can be mitigated by a combined immunosuppressive regimen as assessed by molecular imaging approaches...
  81. ncbi Impact of stage differentiation on diagnosis of toxoplasmosis
    Uwe Gross
    Department of Bacteriology, University Hospital of Gottingen, Gottingen, Germany
    Ann Ist Super Sanita 40:65-70. 2004
    ..This short review focuses on the impact of stage differentiation and discusses the potential of stage-specifically expressed antigens that might be useful in a recombinant form in order to improve future serodiagnostical approaches...
  82. ncbi [Erythema nodoso in reactivation of Chagas' disease after cardiac transplantation]
    Solange Corrêa Garcia Pires d'Avila
    Departamento de Patologia e Medicina Legal, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP
    Rev Soc Bras Med Trop 38:61-3. 2005
    ..This is an unusual presentation of Chagas' disease...
  83. ncbi Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses
    Gil Y Melmed
    Department of Medicine, Division of Gastroenterology, Cedars Sinai Medical Center Los Angeles, California 90048, USA
    Am J Gastroenterol 101:1834-40. 2006
    ..We aimed to assess exposure risk and immunization status among patients receiving care in an IBD specialty clinic...
  84. ncbi Recovery of drug-resistant influenza virus from immunocompromised patients: a case series
    Michael G Ison
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
    J Infect Dis 193:760-4. 2006
    ..We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir...
  85. ncbi Humoral response to the influenza A H1N1/09 monovalent AS03-adjuvanted vaccine in immunocompromised patients
    Oriol Manuel
    Transplantation Center, Infectious Diseases Service, University Hospital of Lausanne CHUV and University of Lausanne, Switzerland
    Clin Infect Dis 52:248-56. 2011
    ..We evaluated the humoral response to the influenza A H1N1/09 vaccine in solid-organ transplant (SOT) recipients, in patients with human immunodeficiency virus (HIV) infection, and in healthy individuals...
  86. ncbi [Usefulness of galactomannan detection in the diagnosis and follow-up of hematological patients with invasive aspergillosis]
    María Dolores Moragues
    Departamento de Enfermería I, EUE, Universidad del Pais Vasco, Vizcaya, Spain
    Rev Iberoam Micol 20:103-10. 2003
  87. ncbi Managing cryptococcosis in the immunocompromised host
    Joseph N Jarvis
    Centre for Infection, Department of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London, UK
    Curr Opin Infect Dis 21:596-603. 2008
    ..In this context, this review summarizes urgently needed recent work aimed at improving the acute management of cryptococcal infection in immunocompromised hosts...
  88. ncbi Trichodysplasia spinulosa associated with chemotherapy for acute lymphocytic leukaemia
    Genevieve M Sadler
    Department of Dermatology, Princess Margaret Hospital, Subiaco, WA, Australia
    Australas J Dermatol 48:110-4. 2007
    ..In case 2, the eruption spontaneously resolved after 9 months. This case report discusses the characteristic clinicopathological features of trichodysplasia spinulosa and, for the first time, follows the condition's natural history...
  89. ncbi Nontyphoidal salmonellosis
    E L Hohmann
    Infectious Diseases Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 32:263-9. 2001
    ..The current report presents a brief overview of the problems and trends associated with salmonellosis that are of interest to the infectious diseases clinician...
  90. ncbi Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients
    F Roblot
    Infectious Diseases Unit, Department of Internal Medicine, La Miletrie, University Hospital, 86021 Poitiers Cedex, France
    Eur J Clin Microbiol Infect Dis 21:523-31. 2002
    ..The diagnosis of PCP should be considered more frequently and advocated earlier in immunocompromised HIV-negative patients, since prompt diagnosis may improve the prognosis of these patients...
  91. ncbi Detection of BK virus and JC virus DNA in urine samples from immunocompromised (HIV-infected) and immunocompetent (HIV-non-infected) patients using polymerase chain reaction and microplate hybridisation
    A Behzad-Behbahani
    Clinical Virology Section, Organ Transplant Research Center OTRC, Shiraz University of Medical Sciences, Shiraz, Iran
    J Clin Virol 29:224-9. 2004
    ..After initial infection both viruses persist within renal system. Reactivation of both viruses may be linked with immunodeficiency or immunosuppressive therapy...
  92. ncbi Progressive trichodysplasia spinulosa in a patient with chronic lymphocytic leukaemia in remission
    Joyce S S Lee
    Skin and Cancer Foundation Australia, Darlinghurst, NSW, Australia
    Australas J Dermatol 49:57-60. 2008
    ..We also describe a painless pull-test where spicules can be easily plucked and assessed microscopically for inner root sheath keratinization, or observed with surface microscopy in a clinic setting...
  93. ncbi Treatment with caspofungin in immunocompromised paediatric patients: a multicentre survey
    Andreas H Groll
    Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Paediatric Haematology Oncology, Children s University Hospital, Muenster, Germany
    J Antimicrob Chemother 57:527-35. 2006
    ..We conducted a multicentre retrospective survey to obtain data on immunocompromised paediatric patients considered to require caspofungin therapy...
  94. pmc Nocardia cyriacigeorgica septicemia
    Sameer Elsayed
    Department of Pathology and Laboratory Medicine, University of Calgary, Alberta, Canada
    J Clin Microbiol 44:280-2. 2006
    ..In both instances, diagnosis was rapidly facilitated by 16S rRNA gene sequencing of blood culture isolates. These constitute the first confirmed reports of Nocardia cyriacigeorgica bloodstream infection in humans...
  95. pmc Brain abscess caused by Nocardia cyriacigeorgica in a patient with human immunodeficiency virus infection
    G Barnaud
    Service de Microbiologie, Hopital Louis Mourier, Colombes, France
    J Clin Microbiol 43:4895-7. 2005
    ..This case confirms that isolation of Nocardia in sputum is associated with a high risk of disseminated infection in immunocompromised patients...
  96. ncbi Influenza vaccination and chemotherapy: a shot in the dark?
    Alistair Ring
    Department of Medical Oncology, Level 03, Department of Medical Oncology, Thomas Guy House, Guys Hospital, London SE1 9RT, England
    Support Care Cancer 10:462-5. 2002
    ..However, the degree of clinical protection afforded may be inferior to that experienced by healthy individuals. Further trials are warranted to assess the magnitude of benefit and optimal schedules of vaccination...
  97. ncbi Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients
    Florencia Pereyra
    Division of Infectious Disease, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Infect Dis 17:357-61. 2004
  98. ncbi The First European Conference on Infections in Leukaemia - ECIL1: a current perspective
    Francoise Meunier
    EORTC, Avenue E Mounier 83 b11, 1200 Brussels, Belgium
    Eur J Cancer 44:2112-7. 2008
    ..Transplantation (EBMT), the Supportive Care Group of the European LeukaemiaNet (ELN) and the International Immunocompromised Host Society (ICHS)...
  99. ncbi Influenza vaccination in children with chronic rheumatic diseases and long-term immunosuppressive therapy
    F Kanakoudi-Tsakalidou
    A Department of Pediatrics, Influenza Reference Center, Aristotle University, Thessaloniki, Greece
    Clin Exp Rheumatol 19:589-94. 2001
    ..To study the immunogenicity, safety and efficacy of influenza vaccine in children with chronic rheumatic diseases (CRD) receiving long-term immunosuppressive therapy...
  100. ncbi PCR diagnosis of Pneumocystis carinii on sputum and bronchoalveolar lavage samples in immuno-compromised patients
    Somchai Pinlaor
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Parasitol Res 94:213-8. 2004
    ..62 and 98.41 percent, respectively. The specificity of PCR was 90% and 98.41% for BAL and sputum samples, respectively. We suggest PCR is an important tool for the epidemiological study of P. carinii in high-risk individuals...
  101. ncbi Comparison between real-time PCR, conventional PCR and different staining techniques for diagnosing Pneumocystis jiroveci pneumonia from bronchoalveolar lavage specimens
    Pierre Flori
    Laboratory of Parasitology and Mycology, Hopital Nord, University Hospital of Saint Etienne, 42055 Saint Etienne, France
    J Med Microbiol 53:603-7. 2004

Research Grants62

  1. Genetics and visualization of innate host response to C. albicans infection in vi
    Robert T Wheeler; Fiscal Year: 2012
    ..A long-term goal of this investigation involves leveraging basic information about host-pathogen interaction to develop therapeutics to treat fungal disease. ..
  2. Transcriptional control of chemokine receptors and naive T cell trafficking
    Eric Sebzda; Fiscal Year: 2013 the cell-intrinsic level (anergy versus intact T cell effector functions) as well as at a host level (immunocompromised host versus effective pathogen clearance versus autoimmunity)...
  3. Phenotypic Switching in Candida albicans and its Role in Pathogenesis
    RICHARD JOHN BENNETT; Fiscal Year: 2010
    ..with emphasis on the role of switching in promoting colonization and infection of distinct sites in the immunocompromised host. Phenotypic switching refers to an epigenetic phenomenon in which cells undergo a reversible and heritable ..
  4. Signal transduction in C. neoformans
    Jennifer K Lodge; Fiscal Year: 2012
  5. Transcriptional regulation of A. fumigatus virulence
    Scott G Filler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Invasive aspergillosis is one of the most feared diseases in the immunocompromised host, and its incidence is steadily increasing...
  6. Modulation of adenovirus pathogenesis by prostaglandin E2
    JASON BRICE WEINBERG; Fiscal Year: 2013
    ..We anticipate that our research will contribute to the development of antiviral treatment strategies based on drugs that modulate prostaglandin production. ..
  7. Novel Methylenecyclopropane Analogues as Anti-Human Herpesvirus 6 and 8 Agents
    Terry L Bowlin; Fiscal Year: 2013
  8. Chitosan in Cryptococcus
    Jennifer K Lodge; Fiscal Year: 2011
  9. NK cells in host defense against invasive aspergillosis
    Borna Mehrad; Fiscal Year: 2013
    ..understanding of the components of the immune response to invasive aspergillosis in the context of an immunocompromised host is important, because it may lead to the development of new treatments aimed at improving the host defense ..
  10. Role of gammaHV68 M1 antigen in Vbeta4+ T cell expansion and fibrosis
    Samuel H Speck; Fiscal Year: 2012
    ..through expression of IFN-?, and the role such T cells might play in mediating chronic disease in an immunocompromised host. The following 3 aims are proposed: Aim 1: Characterize M1 transcript structure(s) and regulation of M1 ..
    ANNECLAIRE DEROOS; Fiscal Year: 2009
    ..After carefully characterizing this pathway, these data will become a useful resource for future studies of NHL in the WHI. ..
  12. The oral mucosal proteome: perturbation in HIV infection and Candida co infection
    Stephen J Challacombe; Fiscal Year: 2010
    ..The long-term objective is to understand the basis of copathogenicity in the immunocompromised host leading to the delivery of more effective therapies...
  13. Intersection of HSV latency and reactivation with the neuronal apoptotic pathway
    ANNA RUTH CLIFFE; Fiscal Year: 2013
    ..periodic reactivation of the vius results in significant morbidity and mortality, particularly in the immunocompromised host. However, the unique characteristics of neurons and molecular events that allow viral persistence and its ..
  14. The role of gammaherpesvirus protein kinase in lytic and latent infection
    Vera L Tarakanova; Fiscal Year: 2010
    ..KSHV) are associated with the development of both solid and lymphoid malignancies, many arising in the immunocompromised host. Unfortunately, the exquisite species specificity of EBV and KSHV limits investigations of primary ..
  15. Pediatric Pharmacology Research Unit Network
    Jeffrey Barrett; Fiscal Year: 2009
    ..The CHOP PPRU will continue to emphasize clinical pharmacologic trials in the immunocompromised host, the critically ill infant and child, and in pediatric pain management...
    JUDITH RHODES; Fiscal Year: 1990
    ..From these studies, a better understanding of a virulence mechanism used by the opportunistic fungus Aspergillus in the pathogenesis of an important clinical problem, invasive aspergillosis, will emerge...
  17. Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG
    Barbara D Alexander; Fiscal Year: 2013
    ..ID: Duke University Hospital is a major transplant and cancer care center with an active Transplant/Immunocompromised Host ID Service, ACGME-accredited Training Programs in ID and Medical Microbiology, and a highly qualified ..
    DON GRAVES; Fiscal Year: 1993
    ..carinii is an opportunistic pathogen that has emerged as an important cause of pneumonia in the immunocompromised host and is particularly important in patients with acquired immune deficiency syndrome (AIDS). Studies on P...
  19. 16th Symposium on Infections in the Immunocompromised Host
    ROBERT WILLIAM FINBERG; Fiscal Year: 2010
    ..Abstract PI: FINBERG, ROBERT WILLIAM Project: 1R13AI091001-01 Title: 16th Symposium on Infections in the Immunocompromised Host Accession Number: 3249194 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS ..
  20. 17th International Symposium on Infections in the Immunocompromised Host
    ROBERT WILLIAM FINBERG; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This application seeks support for the Immunocompromised Host Society's (ICHS) 17th International Symposium on Infections in the Immunocompromised Host...
    David Williams; Fiscal Year: 2001
    ..are increasingly common as opportunistic pathogens which cause significant morbidity and mortality in the immunocompromised host. Despite the growing significance of fungal pathogens there is much that is not known about their ..
  22. Genetic Analysis of Echinocandin Sensitivity
    Santosh Katiyar; Fiscal Year: 2004
  23. IL-17 and Klebsiella Pneumonia
    JUDD SHELLITO; Fiscal Year: 2007
    ..results of these experiments will provide new information on how IL-17 participates in host defense against bacterial pneumonia and may lead to novel approaches to augment immune function in the immunocompromised host.
    Steven Gill; Fiscal Year: 1999
    ..Infections caused by S. aureus are often acute and, in the case of highly invasive strains and/or an immunocompromised host, S...
    Mark Kuhlenschmidt; Fiscal Year: 2000
    ..parvum infection and resultant diarrheal disease. ..
  26. Novel Azole Resistance Mechanisms in Candida albicans
    P Rogers; Fiscal Year: 2004
    ..abstract_text> ..
  27. Microbiology of Stenotrophomonas maltophilia infection
    JOANNA BROOKE; Fiscal Year: 2005
    ..abstract_text> ..
    Martin Myers; Fiscal Year: 1980
    ..In the immunocompromised host with progressive VZV infection, cell-associated viremia occurs in conjunction with exanthem...
    Peter Walzer; Fiscal Year: 2004
    ..least in part by alveolar macrophages; SP-A delays the development and reduces the severity of PcP in the immunocompromised host; SP-A down regulates the host immune/inflammatory response to Pc...
  30. Pathogenesis of Oropharyngeal HHV-8 Infection
    Andrew Johnson; Fiscal Year: 2005
    ..This award will support the pursuit of my long-term career goal, which is to become a proficient independent clinical investigator focusing on infections in the immunocompromised host.
  31. A TB Vaccine for AIDS Patients
    MARCUS AARON HORWITZ; Fiscal Year: 2010
    ..Yet the strains will be safe in the immunocompromised host either because their growth can be easily controlled by the host and immediately stopped if necessary ..
    William Nichols; Fiscal Year: 2004
    ..This award will support my first step towards obtaining my long-term career goal, which is to be a proficient clinical investigator for infections in the immunocompromised host.
    THOMAS FRITSCHE; Fiscal Year: 1991
    ..Details of the pathogenesis of this disease in the immunocompromised host are unclear...
    CONSTANTINE HAIDARIS; Fiscal Year: 2000
    ..caused by the opportunistic fungus Pneumocystis carinii is a major cause of morbidity and mortality in the immunocompromised host, including those with AIDS...
  35. Characterization of Respiratory Pathogens in Transplant Patients
    Mark Poritz; Fiscal Year: 2009
    ..We will test the idea that FilmArray can aid in the diagnosis of respiratory symptoms in transplant patients and thus lead to improved treatment. ..
    Julie Djeu; Fiscal Year: 1991
    ..albicans infections in normal individuals and allow us to begin to identify which component of the PMN-lymphocyte linkage is missing or defective in certain diseases of the immunocompromised host that leads to persistent candidiasis.
    David Bentley; Fiscal Year: 1990
    ..and Infection that will take place during the next biannual International Symposium on Infections in the Immunocompromised Host (ISIIH), Peebles, Scotland, UK, June 3-6, 1990...
    Ann Campbell; Fiscal Year: 2007
    ..or those resulting from reactivation of latent virus causes severe morbidity and mortality in the immunocompromised host, including bone marrow transplant recipients inflicted with various forms of leukemia...
    Edward Mocarski; Fiscal Year: 2000
    ..survival in the immunocompetent host as well as for the generation of acute and chronic diseases in the immunocompromised host. The recent generation of microarrays with thousands of human cDNAs makes it possible to comprehensively ..
    EDMUND DUNKEL; Fiscal Year: 1993
    SO TSANG; Fiscal Year: 1991
    ..carcinoma, African Burkitt's lymphoma, monoclonal and polyclonal lymphoproliferative disorders in immunocompromised host. EBV preferentially infects normal B lymphocytes and results in rapid and efficient transformation of B ..
    John Hay; Fiscal Year: 2000
    ..infection is a major cause of morbidity in children and older adults and may be life threatening in the immunocompromised host. Over 90% of the adult population is seropositive for VZV and are thus candidates for zoster and its ..
  43. Adenoviral vectors to target cells
    Patricia Yotnda; Fiscal Year: 2006
    ..Virus (EBV), since this virus contributes both to Hodgkin Disease and to immunoblastic lymphomas in the immunocompromised host. We have already infected EBV specific-CTLs with a Moloney derived retrovirus containing the adenovirus E1 ..
    William Britt; Fiscal Year: 2001
    Human cytomegalovirus (HCMV) is a major cause of disease in the immunocompromised host. Infection of the central nervous system (CNS) is unusual in allograft recipients but is very common in patients with AIDS and in the newborn infant...
    Randolph Noelle; Fiscal Year: 1991
    ..We extend the hypothesis that mature donor-derived, membrane (m) Ig+ beta cells stably engraft in the immunocompromised host and influence the immune competence of the host...
  46. Detection & Viral Load Monitoring of Adenovirus
    STEVEN KLEIBOEKER; Fiscal Year: 2005
    ..The goal is to show total viral load from optimized specimens correlates with severity and progression of the clinical picture. ..
    Betsy Herold; Fiscal Year: 1993
    ..role of viruses in oncogenesis and means of preventing the devastating effects of viral infections in the immunocompromised host. The specific training program planned includes course work in virology, molecular biology, and immunology ..
  48. Xenogen IVIS-200 Bioluminescent Imaging System
    Alan Pollack; Fiscal Year: 2007
    ..luminescent animals, or tumors derived from cell lines transfected with luminescent genes grown in immunocompromised host animals will be imaged to study molecular changes in animals in response to treatment, detect small ..
  49. Respiratory Syncytial Virus Escape from Immunization
    Wayne Sullender; Fiscal Year: 2004
    ..will define the extent to which RSV becomes resistant to antibodies during prolonged replication in immunocompromised host. In addition, the likelihood that resistant viruses derived in cell culture will maintain normal fitness ..
    George Kemble; Fiscal Year: 2000
    ..or HIV infection may also prevent the morbidity and mortality of severe HCMV disease in the immunocompromised host. The goal of the research proposed in the Phase l SBIR application is to apply recent innovative advances ..
  51. C. Neoformans Infection in Organ Transplant Recipients
    Nina Singh; Fiscal Year: 2005
    ..Finally, the data regarding reactivation or primary infection has implications relevant for the prevention of C. neoformans infection in transplant recipients. ..
  52. Transplant Associated Infection Surveillance Network
    Peter Pappas; Fiscal Year: 2008
    ..Finally, the establishment of a bank will be invaluable in the development and validation of newer diagnostic assays. ..
    Joseph Berger; Fiscal Year: 2002
    ..Dr. Brian Wigdahl, international co-chair of the ISNV, is a co-investigator on this grant. ..
  54. HIV Neuroprotection Workshop
    Joseph Berger; Fiscal Year: 2004
    ..The proposed conference is the first of its kind to highlight neuroprotection in HIV CNS and PNS disorders. By coupling this meeting with the International Symposium on Neurovirology this synergy can be exploited. ..
  55. JCV Virus Expression in Oropharynx and HIV
    Joseph Berger; Fiscal Year: 2004
    ..This line of investigation would add credence to an oropharyngeal mechanism of JCV transmission and may ultimately lead to the clinical identification of an acute illness attributable to this pathogen. ..
    Joseph Berger; Fiscal Year: 2004
    ..It will also open novel avenues for exploring the differential sensitivities of these pathways to HAART, and suggest unique therapeutic options. ..
  57. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..
  58. Pneumocystis in Pathogenesis of HIV-associated Emphysema
    Alison Morris; Fiscal Year: 2009
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from this disease. ..
  59. Respiratory Viruses and Airflow Obstruction after HCT
    Michael Boeckh; Fiscal Year: 2008
    ..These studies will improve our understanding of the interaction between respiratory viruses and late pulmonary complications after HCT, which will ultimately enable us to formulate more rational treatment strategies. ..
    John Wingard; Fiscal Year: 2001
    ..This information is essential to subsequent planning and implementation of relevant, well-aimed interventions to minimize psychosocial disruption and enhance growth in future BMT recipients and their loved ones. ..