immunocompetence

Summary

Summary: The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.

Top Publications

  1. pmc Diet effects on honeybee immunocompetence
    Cedric Alaux
    INRA, UMR 406 Abeilles et Environnement, Laboratoire Biologie et Protection de l abeille, Domaine Saint Paul, Avignon, France
    Biol Lett 6:562-5. 2010
  2. pmc Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review
    Petros I Rafailidis
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Virol J 5:47. 2008
  3. pmc Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice
    Jane E Dalton
    Centre for Immunology and Infection, Hull York Medical School and Department of Biology, University of York, United Kingdom
    J Clin Invest 120:1204-16. 2010
  4. pmc Exposure of immunocompetent adult mice to Pneumocystis carinii f. sp. muris by cohousing: growth of P. carinii f. sp. muris and host immune response
    Chun Li An
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Infect Immun 71:2065-70. 2003
  5. ncbi Immunocompetence and alterations in hepatic gene expression in rainbow trout exposed to CdS/CdTe quantum dots
    F Gagne
    Fluvial Ecosystem Research, Aquatic Ecosystem Research Protection, Water Science and Technology, Environment Canada, Montreal, Quebec, Canada
    J Environ Monit 12:1556-65. 2010
  6. ncbi Cytomegalovirus retinitis in an immunocompetent patient
    Michael W Stewart
    Department of Ophthalmology, Mayo Clinic, Jacksonville, FL 32224, USA
    Arch Ophthalmol 123:572-4. 2005
  7. pmc Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence
    Woelsung Yi
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Clin Invest 120:1324-36. 2010
  8. pmc Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rgammanull mice
    Deepika Rajesh
    Department of Surgery, Transplant Division, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Hum Immunol 71:551-9. 2010
  9. pmc Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
  10. ncbi Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study
    Michael L Jackson
    Group Health Center for Health Studies, Seattle, WA 98101 1448, USA
    Lancet 372:398-405. 2008

Detail Information

Publications264 found, 100 shown here

  1. pmc Diet effects on honeybee immunocompetence
    Cedric Alaux
    INRA, UMR 406 Abeilles et Environnement, Laboratoire Biologie et Protection de l abeille, Domaine Saint Paul, Avignon, France
    Biol Lett 6:562-5. 2010
    ..dietary protein quantity (monofloral pollen) and diet diversity (polyfloral pollen) can shape baseline immunocompetence (IC) by measuring parameters of individual immunity (haemocyte concentration, fat body content and ..
  2. pmc Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review
    Petros I Rafailidis
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Virol J 5:47. 2008
    ..In contrast, relatively little attention has been paid to the morbidity and mortality that CMV infection may cause in immunocompetent patients...
  3. pmc Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice
    Jane E Dalton
    Centre for Immunology and Infection, Hull York Medical School and Department of Biology, University of York, United Kingdom
    J Clin Invest 120:1204-16. 2010
    ....
  4. pmc Exposure of immunocompetent adult mice to Pneumocystis carinii f. sp. muris by cohousing: growth of P. carinii f. sp. muris and host immune response
    Chun Li An
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Infect Immun 71:2065-70. 2003
    ..Once an acquired immune response was initiated, the P. carinii f. sp. muris organisms were quickly eliminated without clinical signs of disease...
  5. ncbi Immunocompetence and alterations in hepatic gene expression in rainbow trout exposed to CdS/CdTe quantum dots
    F Gagne
    Fluvial Ecosystem Research, Aquatic Ecosystem Research Protection, Water Science and Technology, Environment Canada, Montreal, Quebec, Canada
    J Environ Monit 12:1556-65. 2010
    ..On a mass concentration basis, QDs were more potent than dissolved Cd in suppressing immunocompetence in rainbow trout...
  6. ncbi Cytomegalovirus retinitis in an immunocompetent patient
    Michael W Stewart
    Department of Ophthalmology, Mayo Clinic, Jacksonville, FL 32224, USA
    Arch Ophthalmol 123:572-4. 2005
  7. pmc Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence
    Woelsung Yi
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Clin Invest 120:1324-36. 2010
    ..These studies show that DO expression can shape the overall MHCII self-peptide repertoire to promote T cell tolerance...
  8. pmc Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rgammanull mice
    Deepika Rajesh
    Department of Surgery, Transplant Division, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    Hum Immunol 71:551-9. 2010
    We evaluated the immunocompetence of human T cells in humanized NOD-SCID interleukin (IL)-2r-gamma-null (hu-NSG) mice bearing a human thymic organoid, after multilineage reconstitution with isogeneic human leukocytes...
  9. pmc Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
    ....
  10. ncbi Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study
    Michael L Jackson
    Group Health Center for Health Studies, Seattle, WA 98101 1448, USA
    Lancet 372:398-405. 2008
    ..We therefore assessed whether influenza vaccination is associated with a reduced risk of community-acquired pneumonia in immunocompetent elderly people after controlling for health status indicators...
  11. ncbi The combined effect of lead exposure and high or low dietary calcium on health and immunocompetence in the zebra finch (Taeniopygia guttata)
    Tinne Snoeijs
    Behaviour and Ecology Research Group, Department of Biology, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Environ Pollut 134:123-32. 2005
    ..This effect was not found in males, suggesting sexual differences in susceptibility of humoral immunity to lead treatment in zebra finches...
  12. ncbi Effects of heavy metals on immunocompetence of white-footed mice (Peromyscus leucopus)
    Jennifer A Biser
    Department of Biological Sciences, Campus Box 4120, Illinois State University, Normal, Illinois 61790 4120, USA
    J Wildl Dis 40:173-84. 2004
    ..Exposure to contaminants may impair immunocompetence, thereby increasing disease susceptibility...
  13. ncbi Support for the immunocompetence handicap hypothesis in the wild: hormonal manipulation decreases survival in sick damselflies
    Daniel M González-Tokman
    Departamento de Ecologia Evolutiva, Instituto de Ecologia, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 275, Ciudad Universitaria, 04510, Mexico, DF, Mexico
    Evolution 66:3294-301. 2012
    The immunocompetence handicap hypothesis (ICHH) states that hormones enhance sexual trait expression but impair immunity. Previous tests of the ICHH have been hampered by experimental design problems...
  14. ncbi The perils and prospects of using phytohaemagglutinin in evolutionary ecology
    Malcolm W Kennedy
    Division of Ecology and Evolutionary Biology, Institute of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow, UK, G12 8QQ
    Trends Ecol Evol 21:653-5. 2006
    ....
  15. ncbi Effect of selenium on the immunocompetence of patients with head and neck cancer and on adoptive immunotherapy of early and established lesions
    L Kiremidjian-Schumacher
    Division of Biological Sciences, Medicine, and Surgery, New York University College of Dentistry, New York, NY 10010, USA
    Biofactors 14:161-8. 2001
    ..The combined data suggested that local immunotherapy with IL-2 in hosts supplemented with Se may represent an effective modality of treatment for the prevention of recurrences at the site of conventionally treated primary tumors...
  16. ncbi Optimization of an orthotopic murine model of head and neck squamous cell carcinoma in fully immunocompetent mice--role of toll-like-receptor 4 expressed on host cells
    Anne Kristin Vahle
    Department of Otorhinolaryngology, University Hospital Essen, Essen, Germany
    Cancer Lett 317:199-206. 2012
    ..Our data suggest that TLR-4 expressed by host cells is involved in the regulation of tumor-related cachexia and tumor control...
  17. ncbi Infected bronchogenic cyst due to Mycobacterium avium in an immunocompetent patient
    Sheng Hsiang Lin
    Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei County, Taiwan, ROC
    J Infect 51:e131-3. 2005
    ..This is the first reported case of infected bronchogenic cyst caused by M. avium in humans...
  18. ncbi Differential fitness effects of immunocompetence and neighbourhood density in alternative female lizard morphs
    Ryan Calsbeek
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Anim Ecol 77:103-9. 2008
    ..Furthermore, natural selection differentially acted on combinations of female morph and immunocompetence, favouring high levels of immune function in one morph and low levels of immune function in the other. 5...
  19. ncbi Meta-analysis of outcome of cytomegalovirus colitis in immunocompetent hosts
    Polymnia Galiatsatos
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Dig Dis Sci 50:609-16. 2005
    ..A literature search was performed from 1980 to 2003 looking for immunocompetent patients with CMV colitis. Immunocompetence was defined as absence of congenital or acquired immune deficiency, transplant, or immunosuppressive ..
  20. pmc Wolbachia mediate variation of host immunocompetence
    Christine Braquart-Varnier
    Universite de Poitiers, Laboratoire Ecologie, Evolution, Symbiose, UMR CNRS 6556, Poitiers, France
    PLoS ONE 3:e3286. 2008
    ..present paper, we addressed the effect of Wolbachia, the most prevalent endosymbiont in arthropods, on host immunocompetence. To this end, we chose the A...
  21. ncbi Development of immunocompetence: role of micronutrients and microorganisms
    Susanna Cunningham-Rundles
    Department of Pediatrics, Cornell University Weill Medical College, NY, NY, USA
    Nutr Rev 60:S68-72. 2002
    ....
  22. ncbi Enhanced immunocompetence by garlic: role in bladder cancer and other malignancies
    D L Lamm
    Department of Urology, Robert C Byrd Health Science Center West Virginia University, Morgantown, WV 26506 9251, USA
    J Nutr 131:1067S-70S. 2001
    ..Clinical trials should be initiated to test the hypothesis that the immune stimulation and other beneficial effects of garlic are able to reduce the incidence of cancer...
  23. pmc The PHA test reflects acquired T-cell mediated immunocompetence in birds
    Jose L Tella
    Department of Conservation Biology, Estacion Biologica de Donana, Consejo Superior de Investigaciones Cientificas, Sevilla, Spain
    PLoS ONE 3:e3295. 2008
    cological immunology requires techniques to reliably measure immunocompetence in wild vertebrates...
  24. ncbi Female house wrens (Troglodytes aedon) increase the size, but not immunocompetence, of their offspring through extra-pair mating
    Anna M Forsman
    Department of Biological Sciences, Illinois State University, Normal, IL 61790, USA
    Mol Ecol 17:3697-706. 2008
    ..mates, we tested the hypothesis that female house wrens derive indirect genetic benefits, such as enhanced immunocompetence (cutaneous immune activity, humoral immunity, and plasma bactericidal activity) and condition (size and ..
  25. ncbi Clinical and radiographic presentations of pulmonary cryptococcosis in immunocompetent patients
    Chih Jen Yang
    Division of Pulmonary and Critical Care Medicine, Kaohsiung, Taiwan
    Scand J Infect Dis 38:788-93. 2006
    ....
  26. ncbi Bilateral adrenal histoplasmosis in immunocompetent patients
    Chanchal Rana
    Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Diagn Cytopathol 39:294-6. 2011
    ..Adrenal histoplasmosis can occur in immunocompetent individuals and should be considered in differential diagnosis of bilateral adrenal masses in immunocompetent individuals...
  27. ncbi Stress and immunity in wild vertebrates: timing is everything
    Lynn B Martin
    University of South Florida, Department of Integrative Biology, Tampa, FL 33620, USA
    Gen Comp Endocrinol 163:70-6. 2009
    ..When, how and why stressors affect immunity in wild animals remains practically unstudied...
  28. pmc Misidentification and diagnostic delay Caused by a false-positive amplified Mycobacterium tuberculosis direct test in an immunocompetent patient with a Mycobacterium celatum infection
    J H Tjhie
    Department of Medical Microbiology, University Hospital Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands
    J Clin Microbiol 39:2311-2. 2001
    ....
  29. ncbi Primary and secondary immunocompetence in mixed allogeneic chimeras
    Matthew A Williams
    Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, GA, 30322, USA
    J Immunol 170:2382-9. 2003
    ..Our results suggest that while pre-existing T cell memory and primary immunocompetence to acute infection are preserved in mixed allogeneic chimeras, MHC class I and/or class II tissue matching ..
  30. ncbi [Histoplasmosis 45 years after infection in an immunocompetent man]
    Josep M Torres-Rodríguez
    Unitat de Recerca en Malalties Infeccioses i Micologia, Unidad Docente del IMAS, Facultad de Medicina, Universitat Autonoma de Barcelona, Barcelona, Espana
    Rev Iberoam Micol 26:244-6. 2009
    ..capsulatum. Treatment with oral itraconazol during three months leaded to a complete clinical cure, and antibodies disappeared after four years of follow up...
  31. ncbi Granulomatous interstitial nephritis associated with disseminated histoplasmosis in an immunocompetent patient
    Qi Qian
    Division of Hypertension and Nephrology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 58:1018-21. 2011
    ..This report emphasizes the importance of diagnosing histoplasmosis early. A high degree of suspicion is required to make the diagnosis of histoplasmosis in a case of granulomatous interstitial nephritis...
  32. ncbi A case report and literature review of portal vein thrombosis associated with cytomegalovirus infection in immunocompetent patients
    A Squizzato
    Department of Clinical Medicine, University of Insubria, Varese, 21100, Italy
    Clin Infect Dis 44:e13-6. 2007
    ..Published data suggest that CMV hepatitis and, possibly, other types of acute viral hepatitis could be a local risk factor for acute PVT...
  33. ncbi Varicella-zoster meningoencephaloradiculoneuropathy in an immunocompetent young woman
    Vittorio Mantero
    Department of Neurosciences, Niguarda Ca Granda Hospital, Milan, Italy
    J Clin Virol 57:361-2. 2013
    ..Only 5% of patients with zoster develop cranial and peripheral nerve palsies. Diagnosis is imperative in order to initiate prompt antiviral therapy so as to minimize morbidity and the risk of death. ..
  34. pmc Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence
    M Vogel
    Department of Internal Medicine I, Bonn University, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Med Res 16:101-7. 2011
    ..To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy...
  35. ncbi all-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression
    Daiana Martire-Greco
    Laboratorio de Fisiologia de los Procesos Inflamatorios, Instituto de Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM, Buenos Aires, Argentina
    Clin Sci (Lond) 126:355-65. 2014
    ..Our results demonstrate that ATRA restores immunocompetence by modulating the number of leucocytes and the survival of MDSCs, and thus represents an additional potential ..
  36. pmc Differential effects of the mottled yellow and pseudoagouti phenotypes on immunocompetence in Avy/a mice
    D W Roberts
    Proc Natl Acad Sci U S A 81:2152-6. 1984
    ..distinct (mottled yellow and pseudoagouti) mice as well as congeneic (a/a) black mice to evaluate immunocompetence as a function of genotype and phenotype...
  37. ncbi Disseminated cutaneous histoplasmosis in an immunocompetent child, relapsed with itraconazole, successfully treated with voriconazole
    Jyoti Dhawan
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
    Pediatr Dermatol 27:549-51. 2010
    ..We present a rare case of disseminated cutaneous histoplasmosis in an immunocompetent child who relapsed after treatment with amphotericin B followed by itraconazole and was successfully treated with voriconazole...
  38. ncbi Atypical presentation of varicella-zoster virus encephalitis in an immunocompetent adult
    Maria Mpaka
    Intensive Care Unit, University of Thessaly, Larissa, Greece
    Heart Lung 37:61-6. 2008
    ..Varicella-zoster virus encephalitis is uncommon, but not rare, in immunocompetent adults. Typically, patients develop stroke with hemiplegia caused by large vessel vasculopathy days to weeks after herpes zoster ophthalmicus...
  39. ncbi The correlation between immunocompetence and an ornament trait changes over lifetime in Panorpa vulgaris scorpionflies
    Joachim Kurtz
    Institute for Evolutionary Biology and Ecology, University of Bonn, An der Immenburg 1, D 53121, Bonn, Germany
    Zoology (Jena) 110:336-43. 2007
    The immunocompetence-handicap hypothesis posits that costly male ornament traits might function to signal superior heritable immunocompetence to females. Quite a number of studies have aimed at testing this hypothesis...
  40. pmc Unusual clinical presentation of Mycobacterium fortuitum infection in an immunocompetent woman
    Corrado Serra
    Departimento de Scienze e Tecnologie Biomediche, Policlinico Universitario Monserrato, Universita degli Studi di Cagliari, Cagliari, Italy
    J Clin Microbiol 45:1663-5. 2007
    ..We describe a case of nephritis due to M. fortuitum in an immunocompetent woman with a clinical and radiological diagnosis of renal tuberculosis...
  41. ncbi The influence of photoperiod and sex on lipopolysaccharide-induced hypoactivity and behavioral tolerance development in meadow voles (Microtus pennsylvanicus)
    Christopher G Engeland
    Neuroscience Program, University of Western Ontario, Ontario, N6A 5C2 London, Canada
    Psychoneuroendocrinology 28:970-91. 2003
    ....
  42. ncbi Reduced immunocompetence and cost of reproduction in common eiders
    Sveinn Are Hanssen
    Biology Department, Faculty of Science, University of Tromsø, 9037 Tromsø, Norway
    Oecologia 136:457-64. 2003
    b>Immunocompetence may be especially important in long-lived species where infectious organisms may have detrimental effects upon future reproductive value of hosts...
  43. ncbi [Cytomegalovirus myelitis in immunocompetent adult]
    N Ben Abdelhafidh
    Service de Medecine Interne, Hopital Militaire de Tunis, 1008 Mont fleury Tunis, Tunisie
    Rev Med Interne 27:883-5. 2006
    ..Cytomegalovirus (CMV) infection occurs in 40 to 100% of general population. It is often asymptomatic in immunocompetent subject but may induce neurological syndromes such as encephalitis and myelitis...
  44. pmc Immune activation suppresses plasma testosterone level: a meta-analysis
    Jelle J Boonekamp
    Behavioural Biology, University of Groningen, PO Box 14, 9750 AA Haren, The Netherlands
    Biol Lett 4:741-4. 2008
    ..The immunocompetence handicap hypothesis (ICHH) provides a mechanistic explanation of these costs, by proposing a trade-off ..
  45. ncbi Esophageal candidiasis in non-immune suppressed patients in a semi-urban town, southern India
    G Badarinarayanan
    Department of Gastroenterology and Hepatology, AVB Clinic, Perumal East Car Street, Tirunelveli 627 001, India
    Mycopathologia 149:1-4. 2000
    ..Prevalence of Esophageal Candidiasis in non-immune compromised patients in a semi-urban town, was investigated. Further, various investigation procedures to detect the candidal pathogen were compared...
  46. ncbi Cytomegalovirus-associated transverse myelitis in a non-immunocompromised patient
    D Karacostas
    B Department of Neurology, AHEPA Hospital, Aristoteleian University School of Medicine, Thessaloniki, Greece
    Spinal Cord 40:145-9. 2002
    ..Single case report...
  47. ncbi Phenotypes including immunocompetence in scavenging local chicken ecotypes in Tanzania
    P L Msoffe
    Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania
    Trop Anim Health Prod 33:341-54. 2001
    A study was conducted to determine the variations in physical characters and immunocompetence among scavenging local chicken ecotypes in Tanzania...
  48. ncbi Human IgG subclasses and their relation to carbohydrate antigen immunocompetence
    M G Scott
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Diagn Clin Immunol 5:241-8. 1988
    ....
  49. ncbi Safety of revaccination with pneumococcal polysaccharide vaccine
    L A Jackson
    Immunization Studies Program, Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA, USA
    JAMA 281:243-8. 1999
    ..The risk of adverse events associated with revaccination of elderly and chronically ill persons 5 or more years after first vaccination, as is currently recommended, has not been well defined...
  50. pmc Song predicts immunocompetence in male European starlings (Sturnus vulgaris)
    Deborah L Duffy
    Department of Psychology, Behavioral Neuroendocrinology Group, Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Biol Sci 269:847-52. 2002
    According to the immunocompetence handicap hypothesis, sexually selected characteristics predict immune function and this relationship is mediated by testosterone...
  51. ncbi Differences in the peritumoural inflammatory skin infiltrate between squamous cell carcinomas in organ transplant recipients and immunocompetent patients
    Britta Krynitz
    Department of Pathology and Cytology, Karolinska University Laboratories, Stockholm, Sweden
    Acta Derm Venereol 90:379-85. 2010
    ..However, cellular densities were equal, suggesting deviating cellular functionality in OTR...
  52. pmc Incubation temperature affects multiple measures of immunocompetence in young wood ducks (Aix Sponsa)
    Sarah E DuRant
    Department of Fish and Wildlife Conservation, Virginia Tech, Blacksburg, VA 24061, USA
    Biol Lett 8:108-11. 2012
    ..Our results show that incubation temperatures can be an important driver of phenotypic variation in avian populations...
  53. ncbi Atypical transverse myelitis due to cytomegalovirus in an immunocompetent patient
    A Rigamonti
    National Neurological Institute C Besta, Via Celoria 11, I 20133 Milan, Italy
    Neurol Sci 26:351-4. 2005
    ..High CSF anti- CMV IgG index with normal CSF IgG index indicated intact blood-brain barrier, and supported the diagnosis of CMV-induced myelitis in an immunocompetent patient...
  54. ncbi Effects of different levels of zinc on the performance and immunocompetence of broilers under heat stress
    J R Bartlett
    Department of Animal Science, The University of Tennessee, Knoxville, Tennessee 37996 4500, USA
    Poult Sci 82:1580-8. 2003
    ..These results indicate that the immune response of broilers can be influenced by the level of zinc in the diet and by environmental conditions...
  55. ncbi Chronic interstitial lung disease with lung fibrosis in a girl: uncommon sequelae of Epstein-Barr virus infection
    Tobias Ankermann
    Department of Pediatrics, Christian Albrechts University of Kiel, Schwanenweg, Kiel, Germany
    Pediatr Pulmonol 35:234-8. 2003
    ..Treatment with combined inhaled and oral steroids seems to be a treatment option in these patients...
  56. ncbi Normal levels of immunocompetence in possums (Trichosurus vulpecula) exposed to different laboratory housing conditions post capture
    Douglas Begg
    Disease Research Laboratory, Microbiology Department, University of Otago, Dunedin, New Zealand
    Immunol Cell Biol 82:253-6. 2004
    ..The results infer that wild possums adapt quickly post-capture to novel housing conditions and produce representative patterns of immunity when held in housing conditions and fed ad libitum...
  57. ncbi P16 and p53 expression in (pre)malignant epidermal tumors of renal transplant recipients and immunocompetent individuals
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Mod Pathol 16:869-78. 2003
    ..Furthermore, HKIN lesions express significantly more p16 than LKINs and SCCs...
  58. ncbi Zoledronic acid and interleukin-2 treatment improves immunocompetence in HIV-infected persons by activating Vgamma9Vdelta2 T cells
    Fabrizio Poccia
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases, LazzaroSpallanzani I R C C S, Rome 00149, Italy
    AIDS 23:555-65. 2009
    ....
  59. ncbi Unusual presentation of central nervous system cryptococcal infection in an immunocompetent patient
    Gaurav Saigal
    Department of Radiology, Jackson Memorial Hospital, University of Miami, Miami, FL 33136, USA
    AJNR Am J Neuroradiol 26:2522-6. 2005
    ..We report a case of an extremely unusual MR appearance of central nervous system cryptococcosis in a 49-year-old immunocompetent man...
  60. ncbi Microsatellite variability and its relationship with growth, egg production, and immunocompetence traits in chickens
    Rudranath Chatterjee
    Project Directorate on Poultry, Rajendranagar, Hyderabad, Andhra Pradesh, India
    Biochem Genet 48:71-82. 2010
    Variability of microsatellites and a possible relationship with growth, egg production, and immunocompetence traits were estimated for six crossbred chicken populations of White Leghorn...
  61. ncbi Iron, copper and immunocompetence
    Carlos Munoz
    INTA, University of Chile, Santiago, Chile
    Br J Nutr 98:S24-8. 2007
    ..Thus, microminerals contribute to the maintenance of the balance between immunity and health in humans...
  62. pmc Testosterone, ticks and travels: a test of the immunocompetence-handicap hypothesis in free-ranging male sand lizards
    M Olsson
    Department of Zoology, University of Gothenburg, Box 463, 413 90 Gothenburg, Sweden
    Proc Biol Sci 267:2339-43. 2000
    The immunocompetence-handicap hypothesis suggests that androgen-dependent male characters constitute honest signals of mate and/or rival quality because of the imposed costs through immune suppression associated with elevated testosterone ..
  63. ncbi An experimental test of the immunocompetence handicap hypothesis in a teleost fish: 11-ketotestosterone suppresses innate immunity in three-spined sticklebacks
    Joachim Kurtz
    Department of Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, August Thienemann Strasse 2, D 24306 Plon, Germany
    Am Nat 170:509-19. 2007
    The immunocompetence handicap hypothesis (ICHH) provides a functional explanation for how sexual ornaments can provide honest signals of male quality...
  64. ncbi Effects of testosterone and corticosterone on immunocompetence in the zebra finch
    Mark L Roberts
    Centre for Ecology and Conservation, School of Biosciences, University of Exeter, Cornwall Campus, Penryn, Cornwall TR10 9EZ, UK
    Horm Behav 51:126-34. 2007
    The original immunocompetence handicap hypothesis (ICHH) suggested that testosterone has a handicapping effect in males by both promoting the development of sexual signals and suppressing immune function...
  65. pmc Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment
    A Wald
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Clin Invest 99:1092-7. 1997
    ..HSV-2 shedding in the genital mucosa occurs much more frequently than previously appreciated. This frequent reactivation likely plays a role in the epidemic spread of genital herpes worldwide...
  66. ncbi The immunocompetence of Schwann cells
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Muscle Nerve 37:3-13. 2008
    ..b>Immunocompetence, however, has only recently been recognized as an important feature of Schwann cells...
  67. ncbi Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients
    Lonneke A A van Boxtel
    Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Ophthalmology 114:1358-62. 2007
    ....
  68. pmc Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo
    D A Leib
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 189:663-72. 1999
    ..The phenotypes of mutant viruses therefore cannot be interpreted based solely upon studies in cell culture but must be considered carefully in the context of host factors that may define the in vivo phenotype...
  69. ncbi Lymphocyte activation and hepatic cellular infiltration in immunocompetent mice infected by dengue virus
    Hsuen Chin Chen
    Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taiwan
    J Med Virol 73:419-31. 2004
    ..The kinetics of liver enzyme elevation also correlated with that of T cell activation. These data suggest a relationship between T cell infiltration and elevation of liver enzymes...
  70. ncbi Cytomegalovirus meningoencephalitis with paroxysmal course in immunocompetent adults: a new nosographical entity. Clinical, diagnostic and therapeutic correlations, and pathogenetic hypothesis
    F C Devetag
    Department of Neurology and Clinical Neurophysiology, Ospedale S Maria del Prato, ULSS 2, Feltre, Italy
    Eur Neurol 44:242-7. 2000
    ..The clinical, diagnostic and therapeutic aspects of the two types will be analysed, and a pathogenetic hypothesis for the paroxysmal type will be proposed...
  71. ncbi Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals
    C A Harwood
    Department of Academic Dermatology, Royal Hospitals NHS Trust, London, United Kingdom
    J Med Virol 61:289-97. 2000
    ..These data have important implications for future investigation of the role of HPV in cutaneous carcinogenesis at a functional level...
  72. ncbi Enhancement of tumor radioresponse by docetaxel: Involvement of immune system
    K Mason
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Oncol 18:599-606. 2001
    ..Thus, our results showed that docetaxel stimulates tumor infiltration with immune cells, which then participate in antitumor action of docetaxel alone or when combined with radiotherapy...
  73. ncbi Management of Candida species infections in critically ill patients
    Philippe Eggimann
    Medical Clinic II and Intensive Care Unit, and the Infection Control Programme, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland
    Lancet Infect Dis 3:772-85. 2003
    ..Among critically ill patients, azole prophylaxis is effective and is not associated with acquisition of resistance; it must be restricted to highly selected groups of patients at high risk only...
  74. ncbi Adverse events of desirable gain in immunocompetence: the Immune Restoration Inflammatory Syndromes
    Matthias Stoll
    Department of Clinical Immunology, Medical School Hannover, Carl Neuberg Str 1, D 30625 Hannover, Federal Republic of Germany
    Autoimmun Rev 3:243-9. 2004
    ..Therefore, awareness for IRIS is of increasing importance from a clinical point of view. However, diagnostic criteria and standards of treatment still have to be defined...
  75. ncbi Immunocompetence and allergy
    Stephen J McGeady
    Division of Allergy and Clinical Immunology, Nemours Children s Clinic Wilmington, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
    Pediatrics 113:1107-13. 2004
    ..This latter theory has been designated the "hygiene hypothesis." Although there is evidence both for and against both hypotheses, evidence for hypothesis 2 is stronger and more convincing...
  76. ncbi Carotenoid-based bill colour as an indicator of immunocompetence and sperm performance in male mallards
    A Peters
    Reproductive Biology and Behaviour Group, Max Planck Institute for Ornithology, Seewiesen, Starnberg, Germany
    J Evol Biol 17:1111-20. 2004
    ..Our data provide support for current theories that females could use carotenoid-based sexual signals to detect immune vigour and fertilizing ability of prospective mates...
  77. ncbi Interactions between immunocompetence, somatic condition and parasitism in the chub Leuciscus cephalus in early spring
    T Poisot
    Universite Montpellier 2, CNRS, Institut des Sciences de l Evolution, CC 065, Place Eugene Bataillon, 34095 Montpellier Cedex 05, France
    J Fish Biol 75:1667-82. 2009
    Relationships between immunocompetence, somatic condition, parasitism and water temperature in a wild population of chub Leuciscus cephalus were investigated...
  78. ncbi Obesity and immunocompetence
    O Lamas
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Eur J Clin Nutr 56:S42-5. 2002
    ..Limited and often controversial information exists comparing immunocompetence in obese and nonobese subjects as well as the cellular and molecular mechanisms involved, although much ..
  79. ncbi Contrasts in tick innate immune responses to Borrelia burgdorferi challenge: immunotolerance in Ixodes scapularis versus immunocompetence in Dermacentor variabilis (Acari: Ixodidae)
    R Johns
    Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA
    J Med Entomol 38:99-107. 2001
    ..In contrast, D. variabilis is highly immunocompetent (i.e., innate immunity), using plasma borreliacidal factors and a rapid increase in phagocytic cells to clear the infection and limit tissue invasion...
  80. ncbi Transcutaneous immunization and immunostimulant strategies: capitalizing on the immunocompetence of the skin
    Gregory M Glenn
    IOMAI Corporation, Gaithersburg, MD 20878, USA
    Expert Rev Vaccines 2:253-67. 2003
    ..These observations have moved into the clinic, highlighting the likelihood that skin delivery of vaccines will play an important future role in vaccine applications...
  81. pmc Combination effect of oncolytic adenovirotherapy and TRAIL gene therapy in syngeneic murine breast cancer models
    W Guo
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Gene Ther 13:82-90. 2006
    ..These findings provide important considerations in the development and preclinical assessments of oncolytic virotherapy...
  82. ncbi Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and alpha-keto acid homeostasis or immunocompetence
    J Muhling
    Clinic of Anaesthesiology, University Hospital Giessen and Marburg, Justus Liebig University Giessen, Giessen, Federal Republic of Germany
    Amino Acids 33:511-24. 2007
    ....
  83. ncbi Vascular thrombosis and acute cytomegalovirus infection in immunocompetent patients: report of 2 cases and literature review
    Pierre Abgueguen
    Department of Infectious Diseases, Centre Hospitalo Universitaire, Angers, France
    Clin Infect Dis 36:E134-9. 2003
    ..We also review previously reported cases of vascular thrombosis and discuss the propensity of CMV to induce vascular damage with associated thrombosis...
  84. ncbi Pneumocystis jirovecii colonisation in patients with interstitial lung disease
    S Vidal
    Department of Pneumology, Virgen del Rocio University Hospital, Seville, Spain
    Clin Microbiol Infect 12:231-5. 2006
    ..The high prevalence of P. jirovecii carriers found among immunocompetent patients with ILDs in Spain suggests a possible role of P. jirovecii in the natural history of these diseases...
  85. pmc Characterization of transmission of Pneumocystis carinii f. sp. muris through immunocompetent BALB/c mice
    F Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 71:3852-6. 2003
    ..We speculate, based on these results, that transmission from normal host to normal host, as an asymptomatic or minimally symptomatic infection, could be a way to maintain this opportunistic pathogen in the environment...
  86. ncbi [Severe CMV infection: not only in immunocompromised patients]
    O Giroud
    Departement de Medecine, CHCVs Sion
    Rev Med Suisse 6:1918-21. 2010
    ..In these situations antiviral therapy is indicated and the clinical and biological response is very rapidly good. We describe a clinical case and present a review of the literature...
  87. ncbi Preservation of splenic immunocompetence after splenic artery angioembolization for blunt splenic injury
    Ajai K Malhotra
    Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA
    J Trauma 69:1126-30; discussion 1130-1. 2010
    ..However, little is known about splenic immunocompetence after SAE. This study aims at assessing splenic immunocompetence after SAE for BSI.
  88. pmc Pneumocystis carinii f. sp. hominis DNA in immunocompetent health care workers in contact with patients with P. carinii pneumonia
    R F Miller
    Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London, United Kingdom
    J Clin Microbiol 39:3877-82. 2001
    ..The results suggested that HCW in close occupational contact with patients who had P. carinii pneumonia may have become colonized with P. carinii. Carriage was asymptomatic and did not result in the development of clinical disease...
  89. ncbi Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice
    Abdulkadir Omer
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 52:69-75. 2003
    ..In conclusion, NPCCs encapsulated with simple barium alginate can differentiate into beta-cells and reverse high blood glucose levels in immunocompetent mice without immunosuppression for >20 weeks...
  90. ncbi Stress, immunocompetence and leukocyte profiles of pied flycatchers in relation to brood size manipulation
    Petteri Ilmonen
    Section of Ecology, Department of Biology, University of Turku, 20014, Turku, Finland
    Oecologia 136:148-54. 2003
    ..Recently, it has been suggested that these trade-offs may be mediated by stress-induced reduction in immunocompetence. To test the hypothesis that stress reduces immune function, we investigated the effects of brood size ..
  91. pmc The development of IgE-suppressive immunocompetence in young animals: influence of exposure to antigen in the presence or absence of maternal immunity
    E E Jarrett
    Immunology 53:365-73. 1984
    ..The results of feeding antigen to the progeny of (IgG-transmitting) immune mothers indicated that passive and active immunity in the young rat, although both suppressing IgE-responsiveness, do not have additive depressive effects...
  92. ncbi Where are the parasites in the PHA response?
    Jeb P Owen
    Trends Ecol Evol 22:228-9. 2007
  93. ncbi Pneumocystis jiroveci isolates with dihydropteroate synthase mutations in patients with chronic bronchitis
    E Calderon
    Department of Internal Medicine, Virgen del Rocio University Hospital, Seville, Spain
    Eur J Clin Microbiol Infect Dis 23:545-9. 2004
    ....
  94. ncbi Androgen control of immunocompetence in the male house finch, Carpodacus mexicanus Müller
    Pierre Deviche
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    J Exp Biol 208:1287-95. 2005
    The immunocompetence handicap (ICH) hypothesis predicts that elevated levels of the gonadal androgen testosterone (T) entail obligatory costs, such as immunosuppression, but evidence supporting this immunosuppressive influence is ..
  95. pmc Genetic covariance between indices of body condition and immunocompetence in a passerine bird
    Deborah J Gleeson
    School of Integrative Biology, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    BMC Evol Biol 5:61. 2005
    ..Such explanations require a genetic link between immunocompetence and body condition, but existing evidence is limited to phenotypic associations...
  96. ncbi Genetic differences in Pneumocystis isolates recovered from immunocompetent infants and from adults with AIDS: Epidemiological Implications
    Charles B Beard
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention CDC, Fort Collins, CO 80521, USA
    J Infect Dis 192:1815-8. 2005
    ..0001). The observation of different strains circulating in immunocompetent infants and HIV-infected adults suggests independent transmission cycles that warrant further study...
  97. ncbi Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation
    L F Porrata
    Division of Hematology, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Exp Med 4:78-85. 2004
    ....
  98. ncbi Thrombocytopenia due to cytomegalovirus infection in an immunocompetent adult
    Kenichi Nomura
    Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kyoto, Japan
    Hematology 10:405-6. 2005
    ..Recognition for CMV-induced thrombocytopenia is important for early diagnosis...
  99. pmc Pulmonary cytomegalovirus reactivation causes pathology in immunocompetent mice
    Charles H Cook
    Department of Surgery, The Ohio State University, Columbus, USA
    Crit Care Med 34:842-9. 2006
    ..Using an animal model of latency/reactivation, we studied the pathobiology of CMV reactivation in the immunocompetent host...
  100. ncbi Cytomegalovirus enteritis in an immunocompetent host
    Constantinos L Petrogiannopoulos
    2nd Department of Internal Medicine, Hellenic Red Cross Hospital, Athens, Greece
    Chemotherapy 50:276-8. 2004
    ..Histological analysis and high titer of anti-CMV IgM confirmed the diagnosis. A 2-year follow-up was uneventful. CMV enterocolitis is frequent in immunocompromised patients, but rare in immunocompetent subjects...
  101. ncbi Androgens and the immunocompetence handicap hypothesis: unraveling direct and indirect pathways of immunosuppression in song sparrows
    Noah T Owen-Ashley
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    Am Nat 164:490-505. 2004
    The immunocompetence handicap hypothesis proposes that testosterone (T)-dependent sexual signals are honest indicators of male health or genetic quality because only high-quality males are able to withstand the obligate effects of T-..

Research Grants62

  1. OLIGOCLONAL T CELL EXPANSION AND RHEUMATOID ARTHRITIS
    Cornelia M Weyand; Fiscal Year: 2012
    ..question as to what extent defective induction of telomerase and impaired survival of CD4 T cells compromise immunocompetence in RA patients and weaken their anti-microbial immune protection...
  2. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..2) Immune Monitoring, Immunopathology and Immunocompetence: a) to determine if serial monitoring of intracellular cytokine expression including IL-4, IL-10 IFN-?, and ..
  3. Targeting the oral cavity epithelium for inducing mucosal immunity against HIV
    Harvinder Singh Gill; Fiscal Year: 2012
    ..To achieve this goal we will exploit the natural immunocompetence of the oral cavity (OC)...
  4. Genetic control of quantitative traits associated with the metabolic syndrome
    Maria De Luca; Fiscal Year: 2013
    ..variability in skeletal muscle-specific mitochondrial coupling efficiency, whole-body energy metabolism, immunocompetence, and organismal life-history traits...
  5. Developing small molecule therapeutics for lupus
    Thomas R Coleman; Fiscal Year: 2012
    ..and back-up lead in terms of tissue distribution, pharmacokinetics, immunogenicity, as well as residual host immunocompetence, using acute and chronic treatment. 3...
  6. Lipoproteins and Microbial Immunity
    HOBART WHITAKER HARRIS; Fiscal Year: 2013
    ..Yet, precisely how these non-traditional elements of the immune system contribute to host immunocompetence is unclear...
  7. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2013
    ..focal stroke leads to early splenic activation, cytokine-mediated splenic apoptosis and loss of cell-mediated immunocompetence and b) estrogen deficiency exacerbates this pathology; 2) determine if peripheral T lymphocytes play a ..
  8. Stress, Cellular Aging and Susceptibility to Infectious Disease
    Sheldon A Cohen; Fiscal Year: 2010
    ..particularly in CD8 cells), as indicated by decreases in telomere length, may be an important new marker of immunocompetence and, in turn, host resistance to infectious agents...
  9. Drugs of Abuse Affecting AIDS Pathogenesis
    Thomas J Rogers; Fiscal Year: 2012
    ..This application also includes administrative, animal, flow cytometry, and immunohistopathology cores to support the four research projects. PROGRAM PROJECT CHARACTERISTICS ..
  10. Cell Biology of Mycobacterium tuberculosis Infection
    David G Russell; Fiscal Year: 2010
    ..for HIV infection, such as SubSaharan Africa, tuberculosis is invariably the first infection to emerge as immunocompetence wanes...
  11. The MHC of wild chimpanzees: genetic variation, disease and reproductive success
    EMILY ELIZABETH WROBLEWSKI; Fiscal Year: 2012
    ..of disease resistance as studies suggest MHC allelic composition and diversity are directly related to immunocompetence. Furthermore, it will contribute to the understanding of infertility and failed pregnancy due to particular ..
  12. Biological Rhythms and Immune Function
    Brian J Prendergast; Fiscal Year: 2013
    ..of the hypothalamic circadian pacemaker on daily rhythms in the immune system and on organismal-level immunocompetence, and (4) identify the output mechanisms that mediate coupling between the circadian clock and the immune ..
  13. Genetic Modifiers of Immune Evasion by Cytomegalovirus in Glioblastoma
    Janardan P Pandey; Fiscal Year: 2013
    ..Results from the proposed investigation are likely to open a new avenue of investigation in a malignancy that kills approximately 13000 people every year in the U.S. alone. ..
  14. Supplementation of cord blood transplants with limphoid progenitors
    Britte C Beaudette Zlatanova; Fiscal Year: 2010
    ..are the low number of HSC in CB and the high rate of infection due to delayed establishment of immunocompetence. It is hypothesized that supplementing CB transplants with ex vivo- expanded lymphoid progenitors will ..
  15. A+PSA Assay for Improved Prostate Cancer Diagnosis and Risk Assessment
    Gang Zeng; Fiscal Year: 2013
    ..autoantibodies (autoAb) against tumor-associated antigens (TAA) provide critical information about the immunocompetence of the host and the immunogenicity of the endogenously arising tumor...
  16. MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDREN
    Sherwood Gorbach; Fiscal Year: 2005
    ..HIV infection is common, and how infection is related to HIV activity as measured by plasma HIV RNA, or host immunocompetence, as determined by CD4 counts...
  17. MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDREN
    MICHAEL BENNISH; Fiscal Year: 2002
    ..HIV infection is common, and how infection is related to HIV activity as measured by plasma HIV RNA, or host immunocompetence, as determined by CD4 counts...
  18. SELECTION OF THE T CELL RECEPTOR REPERTOIRE
    Pamela J Fink; Fiscal Year: 2011
    ..Aim 1: To assess the immunocompetence and homeostasis of CD4+ T cells expressing revised TCRs...
  19. BLACK FLY IMMUNITY TO ONCHOCERCA SPP
    EDDIE CUPP; Fiscal Year: 1993
    ..We will also evaluate the genetic basis for immunocompetence to filarial infection in Simulium vittalum by electing inbred strains exhibiting a high degree of ..
  20. MicroRNAs and myeloid cell development during sepsis
    MOHAMED A ELGAZZAR; Fiscal Year: 2013
    ..have failed and most deaths now occur during late/chronic sepsis, emerging investigations seek to restore immunocompetence and hasten resolution...
  21. Tolerance and Autoimmunity
    Andrew D Robertson; Fiscal Year: 2010
    ..However, these studies also remind us that some autoreactive cells do mature to immunocompetence in all individuals...
  22. Mixed Chimerism in Haploidentical Non-human Primates
    Bernhard Hering; Fiscal Year: 2006
    ..chimerism confers tolerance to subsequent same donor islet and skin allografts without compromising the immunocompetence of nonhuman primate recipients of peripheral blood stem cell transplants...
  23. ENERGY EXPENDITURE IN BURNED PATIENTS
    Robert Wolfe; Fiscal Year: 1991
    ..Insufficient nutritional support can decrease immunocompetence and wound healing, whereas an excessive caloric burden can cause liver abnormalities and ventilatory distress...
  24. ROLE OF CYTOKINE METABOLISM IN OZONE IMMUNOTOXICITY
    Judith Zelikoff; Fiscal Year: 2001
    ..However, local immune cell populations within the lungs may play a pivotal role in immunocompetence and are likely targets for toxicity from inhaled pollutants...
  25. FACILITATING CELL INDUCED TOLERANCE IN ORGAN TRANSPLANTS
    Yolonda Colson; Fiscal Year: 2001
    The major goal in organ transplantation is to prevent rejection yet preserce recipient immunocompetence. Bone marrow (BM) chimerism, resulting from engraftment of the donor BM stem cell (SC), is associated with long-term donor-specific ..
  26. PATHOGENESIS AND THERAPY OF B19-INDUCED HYDROPS FETALIS
    Cathy Carlson; Fiscal Year: 2000
    ..Monkey fetuses will be inoculated with SPV on days 55 or 85 of gestation, i.e., before or after onset of immunocompetence (which occurs on gestation day 70), respectively...
  27. MECHANISM(S) OF TOXICITY OF THE CHLORINATED P-DIOXINS
    Robert Neal; Fiscal Year: 1980
    ..oxidative phosphorylation, glycolysis, the action of the thyroid or glucocorticoid hormones or decreased immunocompetence as the cause of the acute lethal effects of TCDD...
  28. DRUG SELF ADMINISTRATION IN MOUSE MODELS OF NEUROAIDS
    Lisa Gold; Fiscal Year: 1999
    ..Direct neurotoxic effects of drugs, in addition to their effects on immunocompetence, may contribute to an enhancement of NeuroAIDS disease or accelerate its onset...
  29. Mechanism and Therapies for HAART Induced Diarrhea
    Tibor Sipos; Fiscal Year: 2001
    ..vitamins and nutrients, reduces the absorption of exogenously administered drugs, and leads to reduced immunocompetence. The technical approach for establishing the scientific rationale for the use of a bicarbonate-buffered and ..
  30. ALLOGENEIC LEUKOCYTE INFUSIONS FOR BREAST CANCER
    SCOTT BEARMAN; Fiscal Year: 2000
    ..FISH or short tandem repeat assays in circulating leukocytes, marrow and progenitor cells, (2) evaluation of immunocompetence pre- and post-infusion by both immunophenotyping peripheral blood leukocytes and by specific immune function ..
  31. IMMUNOLOGICAL ASPECTS OF RETINOIDS IN HUMAN CANCER
    Neil Sidell; Fiscal Year: 1993
    ..molecular, and electrophysiologic mechanisms by which retinoids induce the differentiation and modulate the immunocompetence of human lymphocytes...
  32. Ethanol Effects on Human Astroglial Chemokine Expression
    Randall Davis; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Recruitment of leukocytes and microglia is important to immunocompetence in the central nervous system (CMS)...
  33. CARDIOVASCULAR SURGICAL STUDIES OF OMEGA-3 FATTY ACIDS
    D Miller; Fiscal Year: 1991
    ..3) Graft arteriosclerosis and rejection in a rat heterotopic cardiac ALLOGRAFT model. 4) Immunocompetence in rats (humoral and cellular components) using in vivo and in vitro methods...
  34. OBESITY AND INFERTILITY IN THE LETHAL YELLOW MOUSE
    Maureen Diggins; Fiscal Year: 1991
    ..for this study is the heterozygous (Ay/-) female mouse of the C57BL/6J strain which exhibits decreased immunocompetence, obesity and loss of fertility at a relatively early age (approx. 200 days)...
  35. IMMUNOPATHOLOGY X-LINKED LYMPHOPROLIFERATIVE SYNDROME
    DAVID PURTILO; Fiscal Year: 1980
    ..2) Patients with the XLP will be evaluated for general immunocompetence using clinical, hematopathological and immunological and virological techniques...
  36. IMMUNE-RESPONSE CHANGES WITH BLOOD PUMP USE
    Gregory Burns; Fiscal Year: 1991
    ..use of the total artificial heart as either a bridge to cardiac transplantation or as a long-term device, the immunocompetence of recipients becomes critically important...
  37. FIV-MD AS A MODEL FOR AGE-DEPENDENT NEURO-AIDS
    Michael Podell; Fiscal Year: 1999
    ..is that FIV-MD induces age- dependent neurologic impairment in cats that is influenced by changes in immunocompetence and blood-brain barrier (BBB) integrity...
  38. Mechanism of Facilitating Cell-Mediated Tx Tolerance
    Yolonda Colson; Fiscal Year: 2007
    The major goal in solid organ transplantation is to prevent rejection yet preserve recipient immunocompetence. Bone marrow (BM)-induced tolerance for solid organ and cellular grafts has been demonstrated in neonatal and adult models in ..
  39. IMMUNOMODIFIER ACTIVITIES OF PSEUDOMONAS EXOTOXIN A
    Michael Misfeldt; Fiscal Year: 1990
    ..Depending on the immunocompetence of the host, exotoxin A may exert its effect through different immune cell populations...
  40. MUCOSAL IMMUNITY OF THE GENITAL TRACT
    Peggy Crowley Nowick; Fiscal Year: 1999
    ..genital tract; 2) establish a model of normal immune competence in cycling women; and 3) evaluate changes in immunocompetence induced by the introduction of exogenous factors into the vagina...
  41. The Psychoneuroimmunology of Insomnia: Response to a Vaccine Challenge
    WILFRED PIGEON; Fiscal Year: 2009
    ..In addition to the specific assessment of immunocompetence, sleep continuity will be assessed daily with sleep diaries;health status will be assessed weekly with ..
  42. IMMUNE RESPONSE TO THERAPEUTIC TOUCH DURING STRESS
    Melodie Olson; Fiscal Year: 1993
    ..is to evaluate the effectiveness of Therapeutic Touch in reduction of selected stress-related decrements in immunocompetence (thereby improving immunocompetence) in a sample of highly stressed students facing their professional board ..
  43. REGULATION OF MUCOSAL IMMUNOCOMPETENCE IN THE AGING RAT
    Christopher Daniels; Fiscal Year: 1991
    ..population, the increased incidence of gastrointestinal infections and diseases ad the age-related decline in immunocompetence demonstrated the need for a comprehensive, quantitative analysis of the mucosal immune system as a function ..
  44. ENVIRONMENTAL TOBACCO SMOKE AND POSTNATAL INFECTIONS
    SHASHIBHUSHAN SINGH; Fiscal Year: 2000
    ..To our knowledge, none of the studies to date has evaluated the immunocompetence of animals exposed prenatally/postnatally to SS...
  45. CHILDHOOD VICTIMIZATION AND LIFETIME REVICTIMIZATION
    Cathy Spatz Widom; Fiscal Year: 2003
    ..with victimization and revictimization, measured in terms of HPA reactivity (cortisol) and cell mediated immunocompetence (EBV-VCA) using new procedures developed for biological data collection in the field; and (4) to test ..
  46. Endocrine Role of OFQ/N: Studies with Knock-out Mice
    Phyllis Callahan; Fiscal Year: 2002
    ..It is involved in reproduction, as well as being important in mediating the stress response, immunocompetence and maintaining homeostasis...
  47. HOST-RESISTANCE & VIRULENCE IN NAEGLERIA INFECTIONS
    David John; Fiscal Year: 1980
    ..the natural host resistance factors that limit Naegleria infections in the laboratory mouse; for example, immunocompetence; (c) to develop procedures for immunizing mice against fatal disease and; (d) to determine the immunologic ..
  48. ALVEOLAR MACROPHAGES AND DEFENSE OF THE LUNG IN AIDS
    David Weissman; Fiscal Year: 1991
    ..explanation for the high frequency of respiratory tract involvement in AIDS would be localized impairment of immunocompetence. The demonstrated susceptibility of alveolar macrophages to infection with human immunodeficiency virus (HIV),..
  49. OPIOID MODULATION OF IMMUNOCOMPETENCE
    Jean Bidlack; Fiscal Year: 2003
    ..These studies will lay the foundation for determining the cellular mechanisms by which opioids alter immune function and immunological responses to viral infection, including AIDS. ..
  50. IMMUNOLOGIC AND TOXIC MECHANISMS IN BERYLLIUM DISEASE
    Lee Newman; Fiscal Year: 1991
    ..Aim 2, will will test the hypothesis that the toxic effects of beryllium may cause alterations in normal immunocompetence in vitro and in vivo...
  51. CNS EFFECTS ON IFN PRODUCTION AND NK CELL ACTIVITY
    RAYMOND HIRAMOTO; Fiscal Year: 1993
    ..for the benefit of the health of the individual, instead of always being a liability (in terms of suppressed immunocompetence when challenged by adverse circumstances)...
  52. GENETIC ANALYSIS OF B CELL LEUKEMIA
    John Cowell; Fiscal Year: 2001
    ..Morbidity and mortality result from slow progression of the disease which often results in reduced immunocompetence and bone marrow failure...
  53. Steroid Involvement in OFQ/N-Induced Prolactin Secretion
    James Janik; Fiscal Year: 2005
    ..Furthermore, it is important in mediating the stress response, maintaining immunocompetence and even maintaining homeostasis...
  54. DNA-Based Vaccines for Oral Carcnoma
    Theresa Whiteside; Fiscal Year: 2005
    ..b>Immunocompetence of patients will also be monitored...
  55. Stress/Immune Response Effects on HPV-linked Oral Cancer
    Eric Sherman; Fiscal Year: 2004
    ..g.,T-cell proliferative response to HPV16, a specific marker of immunocompetence shown to be associated with viral clearance and disease regression) and quantitative (e.g...
  56. STRUCTURE AND GENETICS OF ANTIBODY VARIABLE REGIONS
    LOVICK CANNON; Fiscal Year: 1980
    ..analyses of anti-streptococcal group A carbohydrate antibodies elicited in strain A mice at three levels of immunocompetence: (1) Early in ontologic development (neonates), (2) Primary immunized (single antigenic stimulus) adults, and ..
  57. Dietary supplementation with glucan enhances immune fn
    David Williams; Fiscal Year: 2002
    ..The development of a dietary supplement which could increase immunocompetence and enhance resistance to common infections would be of significant benefit to human health...
  58. SIGNALING AND AFFECTIVE FUNCTIONS IN CONDITIONING
    HARRY FOWLER; Fiscal Year: 1991
    ..that psychological stress in the form of conditioned fear or frustration can modulate pain sensitivity and immunocompetence. That, in turn, can foster the development of clinically relevant psychological practices for reducing pain ..
  59. NUTRITIONAL REQUIREMENTS FOR IMMUNITY IN THE AGED
    RICHARD WINCHURCH; Fiscal Year: 1993
    ..In previous studies we have shown that supplemental zinc restores a large measure of immunocompetence to aging mice...
  60. IMMUNE FUNCTION IN EXPERIMENTAL DIABETES MELLITUS
    Barry Handwerger; Fiscal Year: 1980
    ..2. To further define the exact nature of the in vivo and in vitro immunological alterations occuring in diabetic mice...
  61. EXERCISE INDUCED IMMUNOMODULATION IN AGING
    ZOHER KAPASI; Fiscal Year: 2000
    ..A long-term goal is to develop therapeutic exercise protocols that enhance immunocompetence with aging.
  62. SOCIAL CONFLICT: IMMUNOLOGICAL & ENDOCRINOLOGICAL CONSEQ
    Mark Lyte; Fiscal Year: 1992
    ....