immune tolerance

Summary

Summary: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.

Top Publications

  1. pmc Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1875-86. 2003
  2. ncbi CTLA-4 control over Foxp3+ regulatory T cell function
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:271-5. 2008
  3. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
  4. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
  5. ncbi Mechanisms of foxp3+ T regulatory cell-mediated suppression
    Ethan M Shevach
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:636-45. 2009
  6. ncbi Endotoxin tolerance: new mechanisms, molecules and clinical significance
    Subhra K Biswas
    Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, 04 01 Immunos, 8A Biomedical Drive, 138648 Singapore
    Trends Immunol 30:475-87. 2009
  7. pmc Myeloid-derived suppressor cells as regulators of the immune system
    Dmitry I Gabrilovich
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Nat Rev Immunol 9:162-74. 2009
  8. pmc The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 332:974-7. 2011
  9. ncbi Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
  10. ncbi Induced CD4+Foxp3+ regulatory T cells in immune tolerance
    Angelina M Bilate
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Annu Rev Immunol 30:733-58. 2012

Research Grants

  1. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2013
  2. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
  3. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
  4. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
  5. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
  6. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
  7. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
  8. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
  9. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
  10. Mechanisms of Peripheral Induction of T-Cell Tolerance
    MATTHEW FRANKLIN MESCHER; Fiscal Year: 2013

Detail Information

Publications327 found, 100 shown here

  1. pmc Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1875-86. 2003
    ..Finally, in a murine asthma model, coadministration of these TGF-beta-induced suppressor T cells prevented house dust mite-induced allergic pathogenesis in lungs...
  2. ncbi CTLA-4 control over Foxp3+ regulatory T cell function
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:271-5. 2008
    ..Thus, natural Tregs may critically require CTLA-4 to suppress immune responses by affecting the potency of antigen-presenting cells to activate other T cells...
  3. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  4. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
    ..These studies identify a specific mechanism of T-cell exhaustion and define a potentially effective immunological strategy for the treatment of chronic viral infections...
  5. ncbi Mechanisms of foxp3+ T regulatory cell-mediated suppression
    Ethan M Shevach
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:636-45. 2009
    ..An increase in our understanding of Treg cell suppressor mechanisms will offer an insight into how Treg cell function can be manipulated either positively or negatively in vivo...
  6. ncbi Endotoxin tolerance: new mechanisms, molecules and clinical significance
    Subhra K Biswas
    Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, 04 01 Immunos, 8A Biomedical Drive, 138648 Singapore
    Trends Immunol 30:475-87. 2009
    ..This review integrates these new findings into an up-to-date account of endotoxin tolerance, its molecular basis and clinical implications in different pathologies...
  7. pmc Myeloid-derived suppressor cells as regulators of the immune system
    Dmitry I Gabrilovich
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Nat Rev Immunol 9:162-74. 2009
    ..In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit...
  8. pmc The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    June L Round
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 332:974-7. 2011
    ..We propose that the immune system can discriminate between pathogens and the microbiota through recognition of symbiotic bacterial molecules in a process that engenders commensal colonization...
  9. ncbi Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
    ..This study reveals pleiotropic functions of TGF-beta signaling in T cells that may ensure a diverse and self-tolerant T cell repertoire in vivo...
  10. ncbi Induced CD4+Foxp3+ regulatory T cells in immune tolerance
    Angelina M Bilate
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Annu Rev Immunol 30:733-58. 2012
    ..Here we review how iTreg cells develop and how they participate in immunological tolerance, contrasting, when possible, iTreg cells with nTreg cells...
  11. pmc How tolerogenic dendritic cells induce regulatory T cells
    Roberto A Maldonado
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Adv Immunol 108:111-65. 2010
    ..Here, we review recent advances in our understanding of the relationship between tolerogenic DCs and Tregs...
  12. ncbi Regulatory T cells mediate maternal tolerance to the fetus
    Varuna R Aluvihare
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Nat Immunol 5:266-71. 2004
    ..Their absence led to a failure of gestation due to immunological rejection of the fetus...
  13. pmc Oral tolerance
    Howard L Weiner
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Immunol Rev 241:241-59. 2011
    ..A major avenue being investigated for the treatment of autoimmunity is the induction of Tregs and mucosal tolerance represents a non-toxic, physiologic approach to reach this goal...
  14. ncbi The NOD mouse: a model of immune dysregulation
    Mark S Anderson
    Diabetes Center, University of California, San Francisco, California 94143, USA
    Annu Rev Immunol 23:447-85. 2005
    ..The information gained from this highly relevant model of human disease will lead to potential therapies that may alter the development of the disease and its progression in patients with T1D...
  15. ncbi Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?
    Manfred B Lutz
    University of Erlangen, Department of Dermatology, Hartmannstr 14, 91052 Erlangen, Germany
    Trends Immunol 23:445-9. 2002
    ..Moreover, the semi-mature DC phenotype is comparable to steady-state migratory veiled DCs within the lymphatics, which seem to continuously tolerize lymph node T cells against tissue-derived self-antigens or apoptotic cells...
  16. ncbi Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
    Usriansyah Hadis
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    Immunity 34:237-46. 2011
    ..We propose a model of stepwise oral tolerance induction comprising the generation of Treg cells in the gut-draining lymph nodes, followed by migration into the gut and subsequent expansion of Treg cells driven by intestinal macrophages...
  17. ncbi CTLA-4-Ig regulates tryptophan catabolism in vivo
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 3:1097-101. 2002
    ..These data suggest that modulation of tryptophan catabolism is a means by which CTLA-4 functions in vivo and that CTLA-4 acts as a ligand for B7 receptor molecules that transduce intracellular signals...
  18. ncbi Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    H Pircher
    Department of Experimental Pathology, University Hospital, Zurich, Switzerland
    Nature 342:559-61. 1989
    ..Thus the same transgenic TCR-expressing T cells may be tolerized at different stages of their maturation and at different locations in the thymus depending on the antigen involved...
  19. ncbi Role of LAG-3 in regulatory T cells
    Ching Tai Huang
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Immunity 21:503-13. 2004
    ..We propose that LAG-3 marks regulatory T cell populations and contributes to their suppressor activity...
  20. ncbi Prevention of allogeneic fetal rejection by tryptophan catabolism
    D H Munn
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 281:1191-3. 1998
    ..Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection...
  21. ncbi Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases
    David S Schneider
    Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA
    Nat Rev Immunol 8:889-95. 2008
    ..An increased understanding of tolerance to pathogen infection could lead to more efficient treatments for infectious diseases and a better description of host-pathogen interactions...
  22. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  23. pmc Indoleamine 2,3-dioxygenase and tumor-induced tolerance
    David H Munn
    Immunotherapy Program, Department of Pediatrics, MCG Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Clin Invest 117:1147-54. 2007
    ..It can also function as an antagonist to other activators of antitumor immunity. Therefore, strategies to block IDO might enhance the effectiveness of tumor immunotherapy...
  24. ncbi Modulation of tryptophan catabolism by regulatory T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 4:1206-12. 2003
    ..Thus, regulation of immunosuppressive tryptophan catabolism in dendritic cells might represent a major mechanism of action of T(R) cells...
  25. pmc The PD-1 pathway in tolerance and autoimmunity
    Loise M Francisco
    Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunol Rev 236:219-42. 2010
    ..Thus, this review also discusses how the PD-1 pathway regulates a number of autoimmune diseases and the therapeutic potential of PD-1: PD-L modulation...
  26. pmc Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance
    Mathias Oertli
    Institute of Molecular Cancer Research, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:3047-52. 2013
    ..In conclusion, our results reveal the molecular players and mechanistic basis for H. pylori-induced immunomodulation, promoting persistent infection and conferring protection against allergic asthma...
  27. ncbi Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    H Nishimura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:141-51. 1999
    ..Collectively, it is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses...
  28. ncbi Tolerogenic dendritic cells: cytokine modulation comes of age
    Sergio Rutella
    Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo Agostino Gemelli, 800168 Rome, Italy
    Blood 108:1435-40. 2006
    ..From a therapeutic standpoint, cytokine-modulated TDCs might be beneficial for prevention and/or treatment of posttransplantation graft-versus-host disease (GVHD) and autoimmunity...
  29. ncbi Tolerogenic dendritic cells
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021 6399, USA
    Annu Rev Immunol 21:685-711. 2003
    ..We suggest that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs...
  30. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
    ..Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation...
  31. ncbi Myeloid-derived suppressor cell heterogeneity and subset definition
    Elisa Peranzoni
    Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
    Curr Opin Immunol 22:238-44. 2010
    ..Moreover, this dichotomy holds true for human MDSCs. We attempt here to summarize conflicting findings in the field and provide some possible, unifying explanations...
  32. pmc Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives
    Paulo C Rodriguez
    Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Immunol Rev 222:180-91. 2008
    ....
  33. ncbi Inflammatory signals in dendritic cell activation and the induction of adaptive immunity
    Olivier Joffre
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
    Immunol Rev 227:234-47. 2009
    ..Here, we review the differences between PRR-triggered and cytokine-induced DC activation and speculate on a potential role for DCs activated by inflammatory signals in tolerance induction rather than immunity...
  34. pmc Differential NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance
    Peter van Baarlen
    Top Institute Food and Nutrition, PO Box 557, 6700 AN, Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 106:2371-6. 2009
    How do we acquire immune tolerance against food microorganisms and commensal bacteria that constitute the intestinal microbiota? We investigated this by stimulating the immune system of adults with commensal Lactobacillus plantarum ..
  35. ncbi A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells
    Bastian Hoechst
    Medizinische Hochschule Hannover, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany
    Gastroenterology 135:234-43. 2008
    ..In this study, we have investigated the frequency and function of a new population of MDSC denoted here as CD14(+)HLA-DR(-/low) in HCC patients. We have also identified a novel, MDSC-mediated immune regulatory pathway in these patients...
  36. pmc Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
    Srinivas Nagaraj
    H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33647, USA
    Nat Med 13:828-35. 2007
    ..These data identify a previously unknown mechanism of T-cell tolerance in cancer that is also pertinent to many pathological conditions associated with accumulation of MDSCs...
  37. pmc Oral tolerance in the absence of naturally occurring Tregs
    Daniel Mucida
    Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Clin Invest 115:1923-33. 2005
    ..However, unlike oral administration of antigen, which induced Tregs but not effector T cells, i.p. immunization led to the simultaneous induction of Tregs and effector Th2 cells displaying the same antigen specificity...
  38. ncbi Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428, Ciudad de Buenos Aires, Argentina
    Nat Rev Immunol 9:338-52. 2009
    ....
  39. pmc Arginase: an emerging key player in the mammalian immune system
    Markus Munder
    Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany
    Br J Pharmacol 158:638-51. 2009
    ..Pharmacological interference with L-arginine metabolism is a novel promising strategy in the treatment of cancer, autoimmunity or unwanted immune deviation...
  40. ncbi Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF
    Luigi Dolcetti
    Istituto Oncologico Veneto, Padova, Italy
    Eur J Immunol 40:22-35. 2010
    ..These data unveil a hierarchy of immunoregulatory activity among MDSC subsets that is controlled by tumor-released GM-CSF...
  41. ncbi Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Semin Cancer Biol 16:53-65. 2006
    ..The present article summarizes recent findings on the interaction between developing cancers and these recently described "myeloid suppressor cells"...
  42. ncbi Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
    O Akbari
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 94305-5208, USA
    Nat Immunol 2:725-31. 2001
    ..These studies show that IL-10 production by DCs is critical for the induction of tolerance, and that phenotypically mature pulmonary DCs mediate tolerance induced by respiratory exposure to antigen...
  43. ncbi Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients
    Carlos del Fresno
    Research Unit, Laboratory of Tumor Immunology, La Paz Hospital, Madrid, Spain
    J Immunol 182:6494-507. 2009
    ..Our results indicate that a tolerant phenotype interferes with timing, efficiency, and outcome of the innate immune responses against bacterial infections...
  44. ncbi Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA
    Stem Cells 27:1954-62. 2009
    ..These findings provide critical information about the immunosuppression of MSCs and for better application of MSCs in treating immune disorders...
  45. pmc MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    Matthew J Delano
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 204:1463-74. 2007
    ..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization...
  46. pmc Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity
    Mauritius Menges
    Department of Dermatology, University of Erlangen, Erlangen 91052, Germany
    J Exp Med 195:15-21. 2002
    ..In conclusion, this study describes that stimulation by TNF-alpha results in incompletely matured DCs (semi-mature DCs) which induce peptide-specific IL-10-producing T cells in vivo and prevent EAE...
  47. ncbi Plasmacytoid dendritic cells in immunity
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 5:1219-26. 2004
    ..Here we review recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases...
  48. ncbi Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice
    Tomoko Shima
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    J Reprod Immunol 85:121-9. 2010
    ....
  49. pmc Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    Paolo Serafini
    Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, University of Miami, School of Medicine, Miami, Florida 33136, USA
    Cancer Res 68:5439-49. 2008
    ....
  50. pmc In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    Flurina Meiler
    Swiss Institute of Allergy and Asthma Research, University of Zurich, 7270 Davos, Switzerland
    J Exp Med 205:2887-98. 2008
    ..Thus, rapid switch and expansion of IL-10-producing Tr1 cells and the use of multiple suppressive factors represent essential mechanisms in immune tolerance to a high dose of allergens in nonallergic individuals.
  51. ncbi Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation
    Maria A Curotto de Lafaille
    Program of Molecular Pathogenesis, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Immunity 29:114-26. 2008
    ..Thus, whereas adaptive Foxp3(+) Treg cells regulate sensitization to allergens and the severity of chronic inflammation, IFN-gamma-producing cells can play a beneficial role in inflammatory conditions involving eosinophils...
  52. ncbi Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance
    Maria Hinterberger
    Institute for Immunology, Ludwig Maximilians Universitat, Munich, Germany
    Nat Immunol 11:512-9. 2010
    ..Our data document an autonomous contribution of mTECs to both dominant and recessive mechanisms of CD4(+) T cell tolerance and support an avidity model of T(reg) cell development versus deletion...
  53. ncbi Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 10:981-91. 2009
    ..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
  54. pmc Dicer-dependent microRNA pathway safeguards regulatory T cell function
    Adrian Liston
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Exp Med 205:1993-2004. 2008
    ..However, in diseased mice, Dicer-deficient T reg cells completely lost suppressor capacity. Thus, miRNA preserve the T reg cell functional program under inflammatory conditions...
  55. ncbi Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?
    Michael D Rosenblum
    Department of Pediatrics, Medical College of Wisonsin, Milwaukee, Wisconsin, USA
    J Invest Dermatol 123:880-7. 2004
    ..immunoregulatory signal through the CD200 receptor (CD200R) to attenuate inflammatory reactions and promote immune tolerance. CD200 expression in the skin has not been described previously...
  56. pmc Tolerogenic plasmacytoid DC
    Benjamin M Matta
    Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Eur J Immunol 40:2667-76. 2010
    ....
  57. ncbi Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
    Brian T Fife
    Department of Medicine, UCSF Diabetes Center, University of California, San Francisco, CA 94113, USA
    Immunol Rev 224:166-82. 2008
    ....
  58. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    ..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases...
  59. ncbi Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells
    Honorio Torres-Aguilar
    Department of Molecular Biomedicine, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico City, Mexico
    J Immunol 184:1765-75. 2010
    ..CD39 was highly expressed only in tDC-TGF, which correlated with increased adenosine production. We propose that these molecules, together with IL-10 and prostanoids, are key factors to induce Ag-specific tolerance in memory T cells...
  60. ncbi Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
    Alberto Sanchez-Fueyo
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Immunol 4:1093-101. 2003
    ..Our data indicate that the Tim-3 pathway provides an important mechanism to down-regulate T(H)1-dependent immune responses and to facilitate the development of immunological tolerance...
  61. pmc Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset
    David A Somerset
    Department of Fetal Medicine, Division of Reproduction and Child Health, University of Birmingham, Birmingham Women s Hospital, Birmingham, United Kingdom
    Immunology 112:38-43. 2004
    ..These data support the concept that normal pregnancy is associated with an elevation in the number of TReg cells which may be important in maintaining materno-fetal tolerance...
  62. ncbi Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    Catherine A Sabatos
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1102-10. 2003
    ..These data indicate that interaction of Tim-3 with Tim-3 ligand may serve to inhibit effector T(H)1 cells during a normal immune response and may be crucial for the induction of peripheral tolerance...
  63. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002
    ..These findings demonstrate an important mechanism of immune regulation...
  64. pmc Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome
    Joanna Groom
    The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, NSW, Australia
    J Clin Invest 109:59-68. 2002
    ..We conclude that altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis...
  65. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
    ..Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens...
  66. ncbi PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling
    Nouara Lhocine
    CNRS, Centre de Genetique Moleculaire, UPR2167, Gif sur Yvette, F 91198, France
    Cell Host Microbe 4:147-58. 2008
    ..Therefore, PIMS is required to establish immune tolerance to commensal bacteria and to maintain a balanced Imd response following exposure to bacterial infections.
  67. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  68. ncbi Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes
    Ian C Boulton
    Department of Medical Genetics and Microbiology, University of Toronto, Medical Sciences Building Rm 4381, 1 Kings College Circle, Toronto, Ontario M5S1A8, Canada
    Nat Immunol 3:229-36. 2002
    ..CEACAM1 bound by gonococcal Opa52 associated with the tyrosine phosphatases SHP-1 and SHP-2, which implicates the receptor's ITIM (immunoreceptor tyrosine-based inhibitory motif) in this effect...
  69. ncbi IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction--a comparative study of human clinical-applicable DC
    Martine A Boks
    Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Clin Immunol 142:332-42. 2012
    ..Moreover, in a functional suppression assay only IL-10 DC induced Treg that strongly suppressed T cell reactivity. Thus, clinical-grade IL-10 DC show functional characteristics that make them best suited for tolerance-inducing therapies...
  70. pmc Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    Thomas Condamine
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Trends Immunol 32:19-25. 2011
    ..Here, we discuss recent findings that describe the molecular mechanisms that regulate the expansion and function of MDSCs, as well as recent attempts to use MDSCs in cell therapy for different pathologic conditions...
  71. ncbi Programming dendritic cells to induce T(H)2 and tolerogenic responses
    Bali Pulendran
    Emory Vaccine Center, Atlanta, Georgia, USA
    Nat Immunol 11:647-55. 2010
    ....
  72. ncbi The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
    Lucy S K Walker
    MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK
    Nat Rev Immunol 11:852-63. 2011
    ..Here, we discuss the data for and against the T cell-intrinsic and -extrinsic functions of CTLA4...
  73. pmc Dendritic cell control of tolerogenic responses
    Santhakumar Manicassamy
    Emory Vaccine Center, Yerkes National Primate Research Center, Department of Pathology, Emory University School of Medicine, Atlanta, GA 30329, USA
    Immunol Rev 241:206-27. 2011
    ....
  74. pmc Control of central and peripheral tolerance by Aire
    Todd C Metzger
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunol Rev 241:89-103. 2011
    ..Furthermore, transgenic antigen expression in extrathymic Aire-expressing cells (eTACs) can mediate deletional tolerance, but the immunological relevance of Aire-dependent, endogenous tissue-specific antigens remains to be determined...
  75. pmc Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis
    Rachel A Harry
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Ann Rheum Dis 69:2042-50. 2010
    ....
  76. ncbi Subsets, expansion and activation of myeloid-derived suppressor cells
    Eliana Ribechini
    Institute of Virology and Immunobiology, University of Wurzburg, Versbacherstrasse 7, Wurzburg, Germany
    Med Microbiol Immunol 199:273-81. 2010
    ..In the present review, we summarize some early work leading to recent findings on these two MDSC subsets, the factors supporting MDSC expansion and activation, as well as novel insights on Gr-1 antibody functions...
  77. pmc Epigenetic mechanisms of regulation of Foxp3 expression
    Girdhari Lal
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Blood 114:3727-35. 2009
    ....
  78. pmc Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance
    Sangeeta Khare
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 7:e42127. 2012
    ..paratuberculosis (MAP) in the intestinal mucosa is associated with host immune tolerance. However, the initial events during MAP interaction with its host that lead to pathogen survival, ..
  79. ncbi Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    Maria A Curotto de Lafaille
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 30:626-35. 2009
    ..iTreg cells are essential in mucosal immune tolerance and in the control of severe chronic allergic inflammation, and most likely are one of the main barriers to ..
  80. ncbi Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    Chandrashekhar Pasare
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 299:1033-6. 2003
    ..This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products...
  81. ncbi Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancer
    Sana Intidhar Labidi-Galy
    Departments of Medical Oncology, Centre de Recherche en Cancérologie de Lyon, Centre Leon Berard, Lyon, France
    Cancer Res 71:5423-34. 2011
    In ovarian cancer, the immune system fails to eradicate established tumors partly due to the induction of immune tolerance within tumor microenvironment...
  82. ncbi Immune tolerance: what is unique about the liver
    Gisa Tiegs
    Division of Experimental Immunology and Hepatology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Autoimmun 34:1-6. 2010
    ..Finally, hepatocytes also contribute to the 'liver tolerance effect' by expression of MHC class II molecules, probably low levels of co-stimulatory molecules and high levels of the co-inhibitory molecule PD-L1...
  83. pmc Tryptophan hydroxylase-1 regulates immune tolerance and inflammation
    Elizabeth C Nowak
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Exp Med 209:2127-35. 2012
    ..acids by catabolic enzymes in the microenvironment is a critical means to control inflammatory responses and immune tolerance. Here we report the novel finding that Tph-1 (tryptophan hydroxylase-1), a synthase which catalyses the ..
  84. ncbi Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite
    Michael Platten
    Department of Neurology and Neurological Sciences, Beckman Center for Molecular Medicine, Stanford University, Stanford, CA 94305, USA
    Science 310:850-5. 2005
    ..Trp catabolites and their derivatives offer a new strategy for treating T(H)1-mediated autoimmune diseases such as MS...
  85. ncbi Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    S Sakaguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Immunol Rev 182:18-32. 2001
    ..They play critical roles not only in preventing autoimmunity but also in controlling tumor immunity and transplantation tolerance...
  86. ncbi Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
    Jessica B Katz
    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    Immunol Rev 222:206-21. 2008
    ..Broad evidence implicates IDO and the tryptophan catabolic pathway in generation of immune tolerance to foreign antigens in tissue microenvironments...
  87. pmc Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells
    Paul L Bollyky
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Leukoc Biol 86:567-72. 2009
    ..Our data suggest that HMW-HA actively promotes immune tolerance by augmenting CD4+CD25+ T(Reg) function, and LMW-HA does not...
  88. ncbi VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics
    Amanda W Lund
    Institute of Bioengineering IBI, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne 1015, Switzerland
    Cell Rep 1:191-9. 2012
    ..Here, we demonstrate that VEGF-C promotes immune tolerance in murine melanoma...
  89. pmc Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice
    Barbara Cassani
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 141:2109-18. 2011
    Induction of oral immune tolerance (OT) blocks proinflammatory responses to orally administered antigens and might be used to treat autoimmune conditions...
  90. ncbi Therapeutic manipulation of immune tolerance in allergic disease
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Obere Strasse 22, Davos Platz, Switzerland
    Nat Rev Drug Discov 8:645-60. 2009
    b>Immune tolerance - the adaptation of the immune system to external antigens or allergens - might be therapeutically manipulated to restore normal immunity in conditions such as allergy, asthma and autoimmune diseases...
  91. ncbi The pathophysiology and treatment of sepsis
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 348:138-50. 2003
  92. ncbi Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    Timothy L Denning
    Vaccine Research Center and Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Nat Immunol 8:1086-94. 2007
    ..This IL-17 production was suppressed by lamina propria macrophages, indicating that a dynamic interaction between these subsets may influence the balance between immune activation and tolerance...
  93. ncbi Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
    Z X Zhang
    Department of Laboratory of Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada
    Nat Med 6:782-9. 2000
    ..These findings provide a novel mechanism of regulatory T-cell-mediated, antigen-specific suppression...
  94. ncbi A function for interleukin 2 in Foxp3-expressing regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1142-51. 2005
    ..T(reg) cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant immune tolerance to self...
  95. ncbi Transforming growth factor-beta: recent advances on its role in immune tolerance
    Pierre Yves Mantel
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard University, Boston, MA, USA
    Methods Mol Biol 677:303-38. 2011
    ..This review summarizes the progresses that have been accomplished on the understanding of TGF-β's signaling in the immune homeostasis and its role in pathogenesis...
  96. pmc Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection
    Tanner M Johanns
    Department of Pediatrics, University of Minnesota School of Medicine, Center for Microbiology and Infectious Disease Translational Research, Minneapolis, Minnesota, United States of America
    PLoS Pathog 6:e1001043. 2010
    ..Together, these results demonstrate that dynamic regulation of Treg suppressive potency dictates the course of persistent bacterial infection...
  97. ncbi Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
    Karin Loser
    Department of Dermatology, University of Munster, D 48149 Munster, Germany
    Nat Med 12:1372-9. 2006
    ..Therefore, environmental stimuli at the skin can rewire the local and systemic immune system by means of RANKL...
  98. pmc Plasmacytoid dendritic cells mediate oral tolerance
    Anne Goubier
    INSERM, U851, 21 Avenue Tony Garnier, Lyon F 69007, France
    Immunity 29:464-75. 2008
    ..These data demonstrate that oral tolerance relies on Ag presentation by pDC to T cells and suggest that pDC could represent a key therapeutic target for intestinal and systemic inflammatory diseases...
  99. pmc Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis
    Jean Marc Cavaillon
    Cytokines and Inflammation Unit, Institut Pasteur, rue Dr Roux, 75015 Paris, France
    Crit Care 10:233. 2006
    ..The term 'cellular reprogramming', which has been proposed to qualify the process of endotoxin tolerance, defines well the immune status of circulating leukocytes in septic and SIRS patients...
  100. ncbi miR-146a mediates protective innate immune tolerance in the neonate intestine
    Cecilia Chassin
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany
    Cell Host Microbe 8:358-68. 2010
    ..interleukin 1 receptor associated kinase 1 (IRAK1) is sufficient to induce intestinal epithelial innate immune tolerance and provide protection from bacteria-induced epithelial damage in neonates...
  101. pmc Oral tolerance: therapeutic implications for autoimmune diseases
    Ana M C Faria
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Belo Horizonte, MG 31270 901, Brazil
    Clin Dev Immunol 13:143-57. 2006
    ....

Research Grants78

  1. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2013
    ..The mechanisms governing immune tolerance are not clear. This proposal will study the mechanisms by which the immune responses are properly controlled...
  2. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..col(V) autioimmunity is causal in the pathogenesis of atherosclerosis, and whether induction of col(V) immune tolerance can ameliorate the morbidity of atherosclerosis...
  3. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..APCs) mediate innate immunity, subsequent activation of the adaptive immune system and in the development of immune tolerance. Perturbation of the balance between defense against pathogens and tolerance of the semi-allogeneic embryo in ..
  4. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..Therapeutics (RTX) is developing a novel soluble receptor decoy receptor fusion protein (hR-421) that induces immune tolerance in antigen (Ag)-specific activated T-cells...
  5. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..This work may lead to novel therapy to inhibit the spread, morbidity, and mortality of cancer in our Veteran population. ..
  6. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..Interestingly, characterization of YYAA mice has led me to a new research interest --autoimmunity and immune tolerance. By comparing two ZAP-70 mutants in the SKG and YYAA mice, I have defined a threshold for autoimmunity versus ..
  7. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
    ..These studies will demonstrate the feasibility of antigen-specific immune tolerance and, if successful, could be adapted for use in humans to more intractable aspects of Graves'disease, ..
  8. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..Therapeutics is developing a novel soluble receptor decoy receptor fusion protein (hR-421) that induces immune tolerance in antigen (Ag)-specific activated T- cells...
  9. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..is less than satisfactory because it is difficult to induce protective immunity against tumor antigens due to immune tolerance to "self" antigens and an immunosuppressive environment induced by the tumor...
  10. Mechanisms of Peripheral Induction of T-Cell Tolerance
    MATTHEW FRANKLIN MESCHER; Fiscal Year: 2013
    ..RELEVANCE: This project focuses on the mechanisms of immune tolerance that prevent CD4+ T cells from causing autoimmunity...
  11. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..centrally-important in the maintenance of pregnancy because their immunosuppressive function allows maternal immune tolerance to the semi-allogeneic fetus. Depletion of Tregs is associated with reproductive failure...
  12. Immune Tolerance and Autoimmunity
    Abul K Abbas; Fiscal Year: 2010
    ..The results are not only of biological significance, but will also provide valuable leads for strategies to induce tolerance as a therapeutic modality. ..
  13. Development of Breast Cancer Vaccines
    WEI ZEN NONE WEI; Fiscal Year: 2013
    PROJECT SUMMARY/ABSTRACT The goal is to use novel, yet straightforward DNA vaccines to overcome immune tolerance to tumor associated antigens, thus inducing anti-tumor immunity to provide long-term protection...
  14. Post Translational Modifications in Tolerance and Autoimmunity
    Mark J Mamula; Fiscal Year: 2012
    ..The goal of this work is to determine the importance of spontaneous protein modification in B and T cell immune tolerance and autoimmune pathology.
  15. Host Factors in Fungal Allergy and Fibrosis
    Anuradha Ray; Fiscal Year: 2010
    ..Allergic Bronchopulmonary Aspergillosis (ABPA) and a basic science project that uses a novel rodent model of immune tolerance or allergy to define the role of the local pulmonary immune system and surfactant proteins in the development ..
  16. MOLECULAR AND CELLULAR REGULATION OF TOLERANCE
    Yongwon Choi; Fiscal Year: 2010
    ..Program Project that seeks to elucidate the molecular mechanisms involved in the induction and maintenance of immune tolerance and the counter-regulation of ongoing immune responses...
  17. Intracellular Targeting of Proinflammatory Pathways to Ameliorate Type 1 Diabetes
    Daniel J Moore; Fiscal Year: 2010
    ..These receptors have been implicated in diabetes pathogenesis and their activation can break immune tolerance. Signaling through these receptors depends on two key adaptor proteins, MyD88 and TRIP...
  18. Immune Tolerance in Non-clonal Immune Systems
    David Nemazee; Fiscal Year: 2013
    This is an R01 renewal application to study the mechanisms and genetics of immune tolerance in mice expressing B cell receptor-reactive superantigens...
  19. Bacterial peptidylarginine deiminase, a link between gums and joint disease
    JAN S POTEMPA; Fiscal Year: 2013
    ..As inflammatory conditions in the lungs of cigarette smokers contributes to the breakdown of immune tolerance to citrullinated epitopes, chronic exposure to citrullinated proteins at periodontitis sites may also ..
  20. Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy
    Matthias Gromeier; Fiscal Year: 2010
    ..cancer vaccines may require combined responses directed against the tumor itself and mechanisms of immune tolerance. We generated a new immunization platform based on Coxsackievirus A21 (CAV21), a common- cold causing ..
  21. NUCLEAR RECEPTOR SIGNALING PATHWAYS IN ATHEROGENESIS
    PETER J TONTONOZ; Fiscal Year: 2013
    ..evidence that the LXR signaling pathway is an important determinant of atherosclerosis susceptibility and immune tolerance. Finally, we identified a novel mechanism whereby LXR activation regulates cholesterol uptake through the LDL ..
  22. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    ..may translate into an earlier, more certain diagnosis of BOS and lead to be better understanding of immune tolerance in lung transplantation...
  23. Durable CD4+ T-cell Tumor Immunity Following Gene-modified HPSC
    Christopher E Touloukian; Fiscal Year: 2013
    ..These treatments, however, have been consistently hampered by poor immunogenicity, limited immune durability, immune tolerance and tumor escape...
  24. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2013
    ..Our initial work shows that in settings of rampant breakdown of immune tolerance, control of autoimmunity is achieved by only a fraction of the available Treg TCR repertoire that was ..
  25. B7-based, CD28 or CTLA-4-specific agonists and antagonists for tolerance inductio
    Roland K Strong; Fiscal Year: 2013
    ..Therefore, efforts at promoting immune tolerance without compromising immune competence are needed to improve outcomes in HCT...
  26. Pathogenesis of HCV in a Novel Mouse Model
    Lishan Su; Fiscal Year: 2010
    ..study the infection and immuno- pathogenesis of HCV, and to test novel immune-based therapeutics to overcome immune tolerance, inflammation, fibrosis and HCC...
  27. Transplacental stem cell transplantation and evaluation of therapeutic effect
    COY HELDERMON; Fiscal Year: 2013
    ..describes a 5 year mentored program to develop scientific expertise in microchimerism, stem cell biology, immune tolerance, and the treatment of inherited diseases...
  28. Mechanisms of Tolerance to Renal Maternal Microchimerism
    ANNE MARGUERITE STEVENS; Fiscal Year: 2011
    ..Long-term persistence to MMc implies immune tolerance, and loss of tolerance to MMc may lead to chronic inflammation within target organs harboring maternal cells...
  29. CELL BIOLOGIC APPROACHES TO DIABETES RESEARCH
    Marco Colonna; Fiscal Year: 2013
    ..cells, 3) processing &presentation of antigens by histocompatibility molecules in Type 1 diabetes, 4) immune tolerance &autoimmunity in Type 1 diabetes, 5) KATP channels &neonatal diabetes, 6) Ca[unreadable]+-independent ..
  30. VSL for Asthma
    Alessio Fasano; Fiscal Year: 2010
    ..Aim 3: To determine that VSL#3 in asthmatic subjects leads to immune tolerance. We will gather data on immune cell subsets using FACS analysis and spontaneous and activated peripheral ..
  31. A Novel Therapy for Restricted Induction of Tolerance to Treat Diabetes Mellitus
    Kanneganti Murthy; Fiscal Year: 2013
    ..We are developing a novel immunomodulatory approach to arrest pancreatic islet injury and restore specific immune tolerance in new-onset Type 1 diabetes mellitus (T1D)...
  32. Antigen Identification in a Novel Model of Spontaneous Autoimmune Ovarian Disease
    Mickie H Cheng; Fiscal Year: 2012
    ..ovarian component that initiates attack of self, I will better understand the common mechanisms that maintain immune tolerance and normally protect our tissues from many forms of autoimmune disease...
  33. Dendritic Cells in the Breaking of Peripheral Tolerance in Type 1 Diabetes
    JONATHAN DAVID KATZ; Fiscal Year: 2012
    ..CD11c+ DC subset responsible for the priming of diabetogenic T cells and cause the functional break in immune tolerance to islet antigen, and (ii) a major reservoir of type 1 interferon needed to drive T1D in NOD mice...
  34. TIM recognition of phosphatidylserine regulates innate and adaptive immunity
    Dale T Umetsu; Fiscal Year: 2013
    ..distinct compartments of mucosal immune responses by affecting cell activation, survival, death and immune tolerance. The results of these studies will greatly impact our understanding of immunity, and may lead to important ..
  35. Mechanisms and Antigen Identification in a Novel Model of Autoimmune Lung Disease
    Anthony Shum; Fiscal Year: 2013
    ..The primary mentor, Dr. Mark Anderson, is a leading expert in central immune tolerance, and co-mentor, Dr...
  36. Mucosal immune response of the anus in women to HPV, intercourse, smoking and OCs
    ANNA BARBARA NONE MOSCICKI; Fiscal Year: 2010
    ..for numerous reasons: 1) the anus has a complex microbiologic environment which requires a level of immune tolerance to commensal organisms, 2) there are often frequent exposures to simultaneous pathogens as well as trauma ..
  37. Paraptosis induction by BK channel activation to improve glioma cancer therapy
    Martin R Jadus; Fiscal Year: 2013
    ..Apoptotic or autophagic cells lead to immune tolerance, while paraptotic cells produce strong immunity...
  38. Oral Therapy for Hemophilia A
    Kam W Leong; Fiscal Year: 2013
    ..Clinical immune tolerance induction (ITI) protocols consist of frequent high-dose factor administrations for a long period of time and ..
  39. Molecular pathogenesis of anti-glomerular basement membrane nephritis
    Dorin Bogdan Borza; Fiscal Year: 2012
    ..Incompletely understood are the molecular mechanisms by which immune tolerance to collagen IV chains is normally established in health, broken in autoimmune anti-GBM disease, or ..
  40. Mucosal Adjuvants Targeting Dendritic Cells
    John G Nedrud; Fiscal Year: 2010
    ..membranes to most dietary and environmental antigens along with commensal micro-organisms leads to a state of immune tolerance rather than immunity...
  41. Restoration of Immune Tolerance in Type 1 Diabetes
    Daniel J Moore; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The failure of immune tolerance is an important underpinning of all human autoimmune diseases. When tolerance fails, autoimmune processes damage vital organs in tens of millions of patients worldwide...
  42. Mechanisms underlying T helper suppression by regulatory T cells
    AYANA JORDAN; Fiscal Year: 2009
    ..uncovering the mechanisms of Treg-mediated suppression of effector T cell function, novel therapies inducing immune tolerance can be developed against a host of autoimmune diseases and cancers...
  43. Th1 and Th17 Mediators in Experimental Emphysema
    Farrah Kheradmand; Fiscal Year: 2013
    ..Specifically ineffective APC function results in immune tolerance, chronic infections, or cancer, whereas aberrant processing of antigen can induce autoimmunity...
  44. Boosting anti-tumor immune responses by modulating genes with nanoparticles
    Jose R Conejo-Garcia; Fiscal Year: 2010
    ..the gateway for transmigrating anti-tumor lymphocytes and therefore emerge as critical orchestrators of immune tolerance in the ovarian cancer microenvironment...
  45. Airway inflammation and HLA-G in asthma
    Steven R White; Fiscal Year: 2013
    ..We concentrate on immune mechanisms that underlie chronic airway inflammation with a clear focus on one immune tolerance molecule, the class I major histocompatibility complex protein human leukocyte antigen (HLA)-G, that we ..
  46. Nuclear receptor mechanisms controlling macrophage function in health and disease
    Ajay Chawla; Fiscal Year: 2013
    ..pathogenic functions of macrophages are well appreciated, their homeostatic functions in tissue repair and immune tolerance remain poorly understood...
  47. Role of epididymal dendritic cells in male reproductive function
    Nicolas Da Silva; Fiscal Year: 2013
    ..that eDCs can interact with the luminal content, including spermatozoa, and regulate the balance between immune tolerance and inflammation...
  48. TREATMENT OF AUTOIMMUNITY WITH REGULATORY T LYMPHOCYTES
    Terrence L Geiger; Fiscal Year: 2013
    ..In Aim 2, we will determine how iTreg induce immune tolerance by diverting a pathologic immune response into a regulatory response, and the specific role of IL-10 in this...
  49. Tumor immunity and escape mechanisms in a UV- and virus-associated skin cancer
    OLGA AFANASIEV; Fiscal Year: 2013
    ..Studies in Aim 2 will investigate immune tolerance by antigen specific regulatory T cells (a subset of which may be UV-induced)...
  50. The roles of Sirt1, a deacetylase, in immune tolerance and autoimmunity
    Deyu Fang; Fiscal Year: 2013
    ....
  51. Training Program in Systemic Autoimmunity
    George C Tsokos; Fiscal Year: 2012
    ..human and animal T cells, B cells, NKT cells, macrophages, mast cells, costimulation, immune cell signaling, immune tolerance, control of cytokine expression and function, pertinent aspects of regional immunology and biology (kidney, ..
  52. Regulatory B cells in the liver
    Susan K Bliss; Fiscal Year: 2010
    ..require a better understanding of the mechanisms underlying the balance between immune responsiveness and immune tolerance within the liver...
  53. Optimizing Tolerance Induction in Peanut Allergy: The DEVIL Study
    Brian Vickery; Fiscal Year: 2013
    ..4) to achieve an independent research career conducting high-impact patient- oriented research focusing on immune tolerance-based therapies for allergic disorders. To accomplish these goals, Dr...
  54. Pathways that regulate monocyte/dendritic cell migration
    Gwendalyn J Randolph; Fiscal Year: 2011
    ..Mature DCs are thought to induce immune priming, but immature DCs are thought to be able to induce immune tolerance. Thus, our studies may be the first to uncover a pathway-initiated by activation of PPAR? in DCs-that could ..
  55. Immune tolerance in the therapy of rheumatoid arthritis
    Salvatore Albani; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): There are few published data concerning the induction and maintenance of immune tolerance based on concurrent clinical and mechanistic studies in rheumatoid arthritis (RA)...
  56. HIV vaccine development using humanized mice
    ROBERT THOMAS WOODLAND; Fiscal Year: 2013
    ..It has been hypothesized that the processes of immune tolerance normally anergizes or deletes such specificities explaining their absence following vaccination or infection...
  57. T Cell Signaling in Rheumatoid Arthritis
    Jorg J Goronzy; Fiscal Year: 2013
    ..module in T cells from RA patients have been reset to favor sustained signaling, thereby impairing peripheral immune tolerance. Our preliminary studies have identified several possible mechanisms causing this hyperresponsiveness ..
  58. Immune Recognition of Citrullinated Cartilage PG Aggrecan in Autoimmune Arthritis
    Katalin Mikecz; Fiscal Year: 2013
    ..ACPA with the severity of arthritis, and (iv) determine whether selective loss of citrullinated G1-specific immune tolerance can lead to arthritis development...
  59. Autogeneic Mitochondria: Surgical Cardioprotection
    James D McCully; Fiscal Year: 2013
    ..Most importantly difficulties over cell isolation, immune tolerance, cellular engraftment and integration remain...
  60. The IRF - type I interferon system in T cell-mediated immune tolerance
    Michael David; Fiscal Year: 2013
    ..The proposed studies will extend our understanding of the contributions of IRFs and type I interferons in the development of Treg cells that are essential in the maintenance of self-tolerance. ..
  61. ACR Basic Research Conference
    Bruce Neil Cronstein; Fiscal Year: 2013
    ..for the Autoimmunity Center of Excellence at Duke and is the Deputy Director of Clinical Affairs for the Immune Tolerance Network and is an expert on B-cells and autoimmune disease...
  62. Understanding Protective Immunoregulatory Mechanisms in the Infant Lung
    Prabir Ray; Fiscal Year: 2013
    ..we have shown the importance of regulatory T cells (Tregs) expressing (mTGF-[unreadable]) in maintaining immune tolerance in the airways of mice...
  63. ApoVax104-HPV as a Novel Vaccine for Cervical Cancer
    KATHRYN MACLEOD; Fiscal Year: 2009
    ..However, the weak antigenic nature of TAAs combined with possible immune tolerance and evasion mechanisms in cancer patients present major hurdles that require potent adjuvants to achieve ..
  64. Immune Tolerance; Sigma Receptor as a Therapeutic Target
    Vadivel Ganapathy; Fiscal Year: 2003
    The goal of this project is to gather evidence in support of a novel strategy for the induction of immune tolerance, namely to use sigma 1 receptor as a potential therapeutic target...
  65. Donor CD8+ cell facilitates mixed chimerism in NOD mice
    Defu Zeng; Fiscal Year: 2005
    ..Therefore, inducing immune tolerance to islet transplants remains an important goal...
  66. SEROLOGICAL EXPRESSION ANALYSIS OF VITILIGO AND ALOPECIA
    Vijayasaradhi Setaluri; Fiscal Year: 2001
    ..This suggests that immune tolerance to self-antigens on pigment producing melanocytes and cells in the hair follicles is broken relatively easily...
  67. Analysis of Human B Cell Tolerance in Humanized Mice
    Roberta Pelanda; Fiscal Year: 2009
    ..These studies reveal gaps in the methodology available to investigators for the analysis of the immune tolerance process in healthy and diseased human individuals, and that it would be useful to have an in vivo system in ..
  68. ApoFasL: a Novel Immunotherapeutic for T1D
    Rolf Huseby; Fiscal Year: 2007
    ..intervention for the treatment of Type 1 diabetes Given the important role played by Fas/FasL system in immune tolerance to self antigens, immune privilege, and lymphocyte homeostasis, and the extensive use of FasL to induce ..
  69. Ethical Issues in Living Donor Transplantation
    Lainie Ross; Fiscal Year: 2009
    ..examine the evolving role of vulnerable populations as living donors;6) to explore the risks and benefits of immune tolerance research performed on live donor transplants;and 7) to propose policy recommendations that achieve a moral ..
  70. Hepatitis B virus e antigen expression
    Shuping Tong; Fiscal Year: 2004
    ..The e antigen (HBeAg) is a secreted soluble protein that promotes immune tolerance during perinatal infection and buffers immunity against HBcAg...
  71. Early Life Exposure to Microbial Products and Asthma
    Joel Kline; Fiscal Year: 2005
    ..has been difficult to directly test in humans; it remains important to identify the pathways that promote immune tolerance among microbe-exposed children...
  72. FcgRIIB links CRP signals with ITGAM functions: a G x G x G model of SLE.
    Alexander J Szalai; Fiscal Year: 2010
    ..that a CRPxFCGR2BxITGAM pathway operates in vivo that dampens the activation state of DCs and fosters immune tolerance, such that inheritance of variants of one or more of these genes that perturbs this pathway increases SLE ..
  73. Fas Ligand Gene Transfer Apoptosis Synovial Fibroblasts
    Haidi Zhang; Fiscal Year: 2004
    ..A transient, localizable, immune tolerance and dose dependent gene transfer may be achieved by a direct intra-articular injection of the FasL gene ..
  74. Innovative Methods for Immune Tolerance in Lung Transpl*
    David Wilkes; Fiscal Year: 2003
    ..MMP expression and activity will be examined in the transplanted lungs of naive and tolerant allograft recipients. Addtionally, systemic and local production of col(V) peptide during allograft rejection ..
  75. Immune Tolerance Against Type I Diabetes in Mice
    Habib Zaghouani; Fiscal Year: 2007
    ..The NOD mouse, which develops spontaneous T1D, as well as mutant NOD strains, will be the animal model of choice for these investigations. ..
  76. Self-and Foreign-Lipids Presented by CD1 in Scleroderma
    Michael Vincent; Fiscal Year: 2003
    ..The physiologic function of CD1d is emerging and evidence exists supporting a role in host defense, immune tolerance, tumor immunity, and autoimmune disease such as systemic lupus, systemic sclerosis, and type I diabetes...
  77. New Approaches to the Biology and Treatment of Myelodysplastic Syndromes (MDS)
    Hagop Kantarjian; Fiscal Year: 2009
    ..normal tissue proteins can be autoantigens for cytotoxic T-lymphocytes (CTL) if peptide overexpression breaks immune tolerance. Preliminary data supporting this hypothesis and suggesting that vaccination with proteinase 3-derived ..
  78. Tolerance to the Nuclear Antigen La
    A Darise Farris; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): A primary knowledge of normal mechanisms of immune tolerance and the kind of determinants recognized by autoreactive T cells are required before the immunological events leading to autoimmunity may be ..