graft survival

Summary

Summary: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.

Top Publications

  1. ncbi Improved graft survival after renal transplantation in the United States, 1988 to 1996
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
    N Engl J Med 342:605-12. 2000
  2. ncbi Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    Herwig Ulf Meier-Kriesche
    University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
    Am J Transplant 4:378-83. 2004
  3. ncbi Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
  4. ncbi Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence
    J Sellares
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:388-99. 2012
  5. ncbi Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    Amelia Bartholomew
    University of Illinois, Chicago 60607, USA
    Exp Hematol 30:42-8. 2002
  6. ncbi Delayed graft function in kidney transplantation
    Norberto Perico
    Department of Medicine and Transplantation, Ospedali Riuniti di Bergamo Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Lancet 364:1814-27. 2004
  7. ncbi Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials
    Dongming Hou
    Indiana University School of Medicine, Indianapolis, IN, USA
    Circulation 112:I150-6. 2005
  8. ncbi Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice
    Willy A Noort
    Department of Hematology, Leiden University Medical Center, Leiden University Medical Center, The Netherlands
    Exp Hematol 30:870-8. 2002
  9. ncbi Long-term renal allograft survival in the United States: a critical reappraisal
    K E Lamb
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Am J Transplant 11:450-62. 2011
  10. ncbi Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    B Salomon
    The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 19:225-52. 2001

Detail Information

Publications298 found, 100 shown here

  1. ncbi Improved graft survival after renal transplantation in the United States, 1988 to 1996
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
    N Engl J Med 342:605-12. 2000
    ..The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known...
  2. ncbi Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    Herwig Ulf Meier-Kriesche
    University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
    Am J Transplant 4:378-83. 2004
    Acute rejection is known to have a strong impact on graft survival. Many studies suggest that very low acute rejection rates can be achieved with current immunosuppressive protocols...
  3. ncbi Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
    ....
  4. ncbi Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence
    J Sellares
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:388-99. 2012
    ..This prospective cohort indicates that many actual failures after indication biopsies manifest phenotypic features of antibody-mediated or mixed rejection and also underscores the major role of nonadherence...
  5. ncbi Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    Amelia Bartholomew
    University of Illinois, Chicago 60607, USA
    Exp Hematol 30:42-8. 2002
    ..We hypothesized that the activities of MSCs in the bone marrow microenvironment might also include immunomodulatory effects on lymphocytes...
  6. ncbi Delayed graft function in kidney transplantation
    Norberto Perico
    Department of Medicine and Transplantation, Ospedali Riuniti di Bergamo Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Lancet 364:1814-27. 2004
    ....
  7. ncbi Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials
    Dongming Hou
    Indiana University School of Medicine, Indianapolis, IN, USA
    Circulation 112:I150-6. 2005
    ..We evaluated the short-term fate of peripheral blood mononuclear cells (PBMNCs) after intramyocardial (IM), intracoronary (IC), and interstitial retrograde coronary venous (IRV) delivery in an ischemic swine model...
  8. ncbi Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice
    Willy A Noort
    Department of Hematology, Leiden University Medical Center, Leiden University Medical Center, The Netherlands
    Exp Hematol 30:870-8. 2002
    ..In cotransplantation experiments, we examined the homing of MSC as well as the effect on engraftment of human umbilical cord blood (UCB)-derived CD34(+) cells in NOD/SCID mice...
  9. ncbi Long-term renal allograft survival in the United States: a critical reappraisal
    K E Lamb
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Am J Transplant 11:450-62. 2011
    ..progress that has occurred over the last two decades in renal transplantation is mostly driven by improvements in short-term graft survival but long-term attrition is slowly improving and could lead to bigger advances in the future.
  10. ncbi Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    B Salomon
    The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 19:225-52. 2001
    ..The implications of these complexities and the potential for use of these therapies in clinical immune intervention are discussed...
  11. ncbi A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)
    A Durrbach
    Bicetre Hospital, Kremlin Bicetre, IFRNT, Universite Paris Sud, France
    Am J Transplant 10:547-57. 2010
    ..The co-primary endpoints at 12 months were composite patient/graft survival and a composite renal impairment endpoint...
  12. ncbi Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
    Z X Zhang
    Department of Laboratory of Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada
    Nat Med 6:782-9. 2000
    ..These findings provide a novel mechanism of regulatory T-cell-mediated, antigen-specific suppression...
  13. ncbi Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function
    Taihei Ito
    Southern California Islet Cell Resources Center, Department of Diabetes, Endocrinology, and Metabolism, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Transplantation 89:1438-45. 2010
    ..Bone marrow-derived mesenchymal stem cells (MSCs) are known to produce vascular endothelial growth factor. We hypothesize that co-transplantation of MSCs and islets promotes revascularization and improves islet graft function...
  14. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
    ....
  15. ncbi Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
    ..C4d-negative SAMR patients displayed an intermediate course between the no-SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR...
  16. ncbi Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining
    Banu Sis
    Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 9:2312-23. 2009
    ..94%) than C4d. The results were validated in independent set of 82 kidneys. High renal endothelial transcript expression in patients with alloantibody is indicator of active antibody-mediated allograft damage and poor graft outcome...
  17. ncbi KIR-ligand mismatches are associated with reduced long-term graft survival in HLA-compatible kidney transplantation
    J van Bergen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 11:1959-64. 2011
    ..minimized, KIR-ligand mismatches were associated with an approximately 25% reduction in 10-year death-censored graft survival (p = 0.043)...
  18. ncbi Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts
    Neal R Barshes
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin, Suite 1628, Houston, TX 77030, USA
    J Leukoc Biol 77:587-97. 2005
    ....
  19. ncbi Interventional strategies to prevent beta-cell apoptosis in islet transplantation
    Juliet A Emamaullee
    Surgical Medical Research Institute, University of Alberta, Edmonton, AB T6G 2N8
    Diabetes 55:1907-14. 2006
    ..In addition, XIAP has enhanced long-term murine islet allograft survival. The complexities of both intrinsic and extrinsic apoptotic pathway inhibition are discussed in depth...
  20. ncbi Solid organ allograft survival improvement in the United States: the long-term does not mirror the dramatic short-term success
    S A Lodhi
    Division of Nephrology, Hypertension and Renal Transplantation, Department of Medicine, University of Florida, FL, USA
    Am J Transplant 11:1226-35. 2011
    ..Long-term graft survival was analyzed using data on adult solid organ transplant recipients from the UNOS/SRTR database and is reported ..
  21. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    ..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases...
  22. ncbi The technique for heterotopic cardiac transplantation in mice: experience of 3000 operations by one surgeon
    M Niimi
    Department of Surgery, Teikyo University, Tokyo, Japan
    J Heart Lung Transplant 20:1123-8. 2001
    ..The mouse heterotopic fully vascularized cardiac transplantation model has come into widespread use. However, the technique is still difficult. Therefore, simple anastomosis was introduced...
  23. ncbi Corneal graft outcome study
    M Sit
    Faculty of Medicine, University of Toronto, Canada
    Cornea 20:129-33. 2001
    PURPOSE: To determine overall 2- and 5-year corneal graft survival rates and to identify risk factors for corneal graft failure in our patient population...
  24. ncbi Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:2666-73. 2004
    To evaluate the occurrence and time course of hem- and lymphangiogenesis after normal-risk corneal transplantation in the mouse model and to test whether pharmacologic strategies inhibiting both processes improve long-term graft survival.
  25. ncbi Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure
    G Einecke
    Alberta Transplant Applied Genomics Centre, Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 9:2520-31. 2009
    ..We analyzed histopathology, HLA antibodies and death-censored graft survival in 234 consecutive biopsies from 173 patients, taken 6 days to 31 years posttransplant...
  26. ncbi Antibodies against MICA antigens and kidney-transplant rejection
    Yizhou Zou
    Transplantation Immunology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8886, USA
    N Engl J Med 357:1293-300. 2007
    ..We sought to determine whether an immune response to MICA antigens might play a role in the failure of kidney allografts...
  27. ncbi Three-year outcomes from BENEFIT, a randomized, active-controlled, parallel-group study in adult kidney transplant recipients
    F Vincenti
    University of California, San Francisco, Kidney Transplant Service, San Francisco, CA, USA
    Am J Transplant 12:210-7. 2012
    ..Belatacept-treated patients maintained a high rate of patient and graft survival that was comparable to cyclosporine-treated patients, despite an early increased occurrence of acute rejection ..
  28. pmc Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responses
    Michele Carvello
    Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:155-65. 2012
    ..Islet graft survival was significantly prolonged in B-cell-depleted mice compared with control groups in transplants of islets from ..
  29. ncbi Once-daily extended-release versus twice-daily standard-release tacrolimus in kidney transplant recipients: a systematic review
    Elaine T L Ho
    Centre for Transplant and Renal Research, Westmead Hospital, Westmead, New South Wales, Australia 2145
    Transplantation 95:1120-8. 2013
    ..We aimed to identify, appraise, and synthesize the current evidence comparing the relative safety and efficacy of the recently introduced daily versus standard twice-daily tacrolimus administration...
  30. ncbi Long-term renal allograft survival: have we made significant progress or is it time to rethink our analytic and therapeutic strategies?
    Herwig Ulf Meier-Kriesche
    Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Transplant 4:1289-95. 2004
    ..The improvement seems to be driven primarily by the improvement in graft survival of re-transplants. First transplants showed a cumulative increase in graft survival of less than 6 months...
  31. pmc Access and outcomes among minority transplant patients, 1999-2008, with a focus on determinants of kidney graft survival
    P Y Fan
    Division of Renal Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Transplant 10:1090-107. 2010
    ..Age and duration of pretransplant dialysis exposure emerge as the most important determinants of survival in an investigation of the relative impact of center-related versus patient-related variables on kidney graft outcomes...
  32. ncbi The Donor-Risk-Index, ECD-Score and D-MELD-Score all fail to predict short-term outcome after liver transplantation with acceptable sensitivity and specificity
    Harald Schrem
    General, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany
    Ann Transplant 17:5-13. 2012
    ..This study investigates the ability of the Donor-Risk-Index (DRI), the Extended-Criteria-Donor-Score (ECD-score) and the D-MELD-score to predict early outcome after liver transplantation...
  33. ncbi Immunosuppression: evolution in practice and trends, 1994-2004
    H U Meier-Kriesche
    University of Florida, Gainesville, FL, USA
    Am J Transplant 6:1111-31. 2006
    ..The percentage of patients treated for acute rejection during the first year following transplantation has continued to decline, reaching 13% for those who received a kidney in 2003, 48% of which cases were treated with antibodies...
  34. ncbi De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure
    L G Hidalgo
    Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 9:2532-41. 2009
    ..De novo DSA correlated with reduced graft survival after the biopsy...
  35. pmc Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin-17 secreting cell in renal allograft biopsies with acute T-cell-mediated rejection
    Byung H Chung
    Convergent Research Consortium for Immunological Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Immunology 136:344-51. 2012
    ..The FOXP3/IL-17 ratio is a useful indicator for representing the severity of tissue injury, allograft dysfunction and for predicting the clinical outcome of ATCMR...
  36. ncbi De novo DQ donor-specific antibodies are associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy
    Michelle Willicombe
    Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, UK
    Transplantation 94:172-7. 2012
    ..The aim of this study was to establish the incidence and outcomes after the development of DQ DSAbs along with the impact of class II HLA mismatch on their development...
  37. pmc B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months
    M M Mohiuddin
    Cardiothoracic Surgery Research Program, National Heart Lung and Blood Institute NIH, Bethesda, MD, USA
    Am J Transplant 12:763-71. 2012
    ..hCD46Tg graft survival for up to 236 days (n = 9, median survival 71 days and mean survival 94 days)...
  38. pmc IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients
    Paloma Riquelme
    Department of Surgery, Laboratory for Transplantation Research, University Hospital Regensburg, Regensburg, Germany
    Mol Ther 21:409-22. 2013
    ..Clinical applications of M reg therapy as an adjunct immunosuppressive therapy are currently being investigated within The ONE Study...
  39. ncbi Effect of obesity on the outcome of kidney transplantation: a 20-year follow-up
    Ellen K Hoogeveen
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 91:869-74. 2011
    ..Cardiovascular disease is both a major threat to the life expectancy of kidney transplant recipients and an important determinant of late allograft loss. Obesity is an important risk factor for cardiovascular disease...
  40. pmc 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival
    Sarah S Zaher
    Department of Immunology, Division of Medicine, Imperial College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:2640-8. 2011
    ..This study was conducted to examine the effect of kynurenines, the products of tryptophan breakdown and known to act directly on T lymphocytes, on corneal graft survival.
  41. ncbi Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies
    Gerhard Opelz
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Lancet 365:1570-6. 2005
    ..Transplants from HLA-identical sibling donors do not provide a target for antibodies to HLA antigens and should therefore not be affected by PRA...
  42. ncbi Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival
    P I Terasaki
    Terasaki Foundation Laboratory, Los Angeles, CA, USA
    Am J Transplant 7:408-15. 2007
    ..Four years after testing, deceased donor graft survival among 806 patients not having antibodies in 2002 was 81% compared to 58% for 158 patients with HLA antibodies (..
  43. ncbi Ten-year survival of second kidney transplants: impact of immunologic factors and renal function at 12 months
    Stephanie Coupel
    Institut de Transplantation et de Recherche en Transplantation and INSERM U437, Immunointervention en Allo et Xénotransplantations, Nantes, France
    Kidney Int 64:674-80. 2003
    ..The aim of the present study was to assess long-term survival of cadaveric second kidney allografts performed in our center and to determine risk factors predictive of long-term graft outcome...
  44. ncbi CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates
    Tatsuo Kawai
    Department of Surgery, Transplantation Unit, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 4:1391-8. 2004
    ..Modification of the original mixed chimerism approach, by the addition of costimulatory blockade, has been shown to enhance mixed chimerism and induce renal allograft tolerance with less morbidity in nonhuman primates...
  45. ncbi High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response
    Lihua Duan
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Lab Invest 91:43-53. 2011
    ....
  46. ncbi Relationship between the interleukin-28b gene polymorphism and the histological severity of hepatitis C virus-induced graft inflammation and the response to antiviral therapy after liver transplantation
    Dennis Eurich
    Department of General, Visceral, and Transplant Surgery, Charite, Campus Virchow, Berlin, Germany
    Liver Transpl 17:289-98. 2011
    ..G-allele might serve as a marker for graft inflammation and as a predictor for unfavorable antiviral therapy outcome in HCV-re-infected LT-population...
  47. pmc Flt23k nanoparticles offer additive benefit in graft survival and anti-angiogenic effects when combined with triamcinolone
    Yang Kyung Cho
    Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah 84132, USA
    Invest Ophthalmol Vis Sci 53:2328-36. 2012
    ..To determine if nanoparticles delivering plasmids expressing Flt23k (an anti-VEGF intraceptor) can enhance murine cornea transplant survival and whether their effect is synergistic with steroid therapy...
  48. doi Effect on kidney graft survival of reducing or discontinuing maintenance immunosuppression after the first year posttransplant
    Gerhard Opelz
    Transplantation 86:371-6. 2008
    ..Data are scarce concerning the impact of maintenance immunosuppression dose reductions posttransplant...
  49. ncbi C4d-negative antibody-mediated rejection in renal allografts: evidence for its existence and effect on graft survival
    M Haas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Clin Nephrol 75:271-8. 2011
    ....
  50. pmc Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates
    Y Yamada
    Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:330-40. 2012
    ..Using this modified approach, mixed chimerism was induced successfully in 11 of 13 recipients of previously placed renal allografts and long-term survival without immunosuppression could be achieved in at least 6 of these 11 animals...
  51. pmc LFA-1-specific therapy prolongs allograft survival in rhesus macaques
    Idelberto R Badell
    Emory Transplant Center, Emory University, Atlanta, Georgia, USA
    J Clin Invest 120:4520-31. 2010
    Outcomes in transplantation have been limited by suboptimal long-term graft survival and toxicities associated with current immunosuppressive approaches...
  52. ncbi Treatment with plerixafor in non-Hodgkin's lymphoma and multiple myeloma patients to increase the number of peripheral blood stem cells when given a mobilizing regimen of G-CSF: implications for the heavily pretreated patient
    Patrick Stiff
    BMT Program, Loyola University Stritch School of Medicine, Maywood, Illinois, USA
    Biol Blood Marrow Transplant 15:249-56. 2009
    ..Plerixafor and G-CSF increased circulating CD34 cells/microL and led to the adequate collection of stem cells for autotransplant in 96% of the patients. This combination may have particular value in heavily pretreated patients...
  53. ncbi Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation
    S H Huang
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Diabetologia 53:2389-400. 2010
    ..We investigated whether transgenic expression of Ho-1 (also known as Hmox1) in pancreatic beta cells would protect NOD mice from autoimmune damage and prolong graft survival following islet transplantation.
  54. ncbi Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture
    Christian Toso
    Clinical Islet Transplant Program, Department of Surgery, University of Alberta, Edmonton, AB, Canada
    Transpl Int 23:259-65. 2010
    ..Overall, these data demonstrate the beneficial effect of liraglutide on cultured human islets, preserving islet mass. They support the design of clinical studies looking at the effect of liraglutide in clinical islet transplantation...
  55. ncbi Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patients
    Ella M van den Berg-Loonen
    University Hospital Maastricht, The Netherlands
    Transplantation 85:1086-90. 2008
    ..The standard crossmatch in the AM program is based on complement-dependent cytotoxicity...
  56. ncbi Incidence and cost of new onset diabetes mellitus among U.S. wait-listed and transplanted renal allograft recipients
    Robert S Woodward
    Department of Health Management and Policy, University of New Hampshire, Durham, NH, USA
    Am J Transplant 3:590-8. 2003
    ..We estimated the cost of diabetes attributable to maintenance immunosuppression regimens to be $2025 and $3308 for each tacrolimus patient and $1137 and $1611 for each cyclosporine patient at 1 and 2 years post-transplant, respectively...
  57. ncbi Messenger RNA for FOXP3 in the urine of renal-allograft recipients
    Thangamani Muthukumar
    Division of Nephrology, Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 353:2342-51. 2005
    ..The outcome of renal transplantation after an episode of acute rejection is difficult to predict, even with an allograft biopsy...
  58. ncbi AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data
    G Calandra
    AnorMED Corp of Genzyme Corp, Langley, British Columbia, Canada
    Bone Marrow Transplant 41:331-8. 2008
    ..AMD3100 plus G-CSF offers a new treatment to collect CD34+ cells for autologous transplant from poor mobilizers, with a high success rate...
  59. ncbi Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome
    Judith E Worthington
    Transplantation Laboratory, Manchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    Transplantation 75:1034-40. 2003
    ..This study aimed to determine whether the production, in renal transplant recipients, of antibodies directed against donor HLA mismatches is predictive of transplant failure...
  60. pmc Current status of xenotransplantation and prospects for clinical application
    Richard N Pierson
    Division of Cardiac Surgery, Department of Surgery, University of Maryland, Baltimore VAMC, Baltimore, MD 21201, USA
    Xenotransplantation 16:263-80. 2009
    ..This review offers a comprehensive overview of known mechanisms of xenograft injury, a contemporary assessment of preclinical progress and residual barriers, and our opinions regarding where breakthroughs are likely to occur...
  61. ncbi Major effects of delayed graft function and cold ischaemia time on renal allograft survival
    Isabel Quiroga
    Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, OX3 7LJ, UK
    Nephrol Dial Transplant 21:1689-96. 2006
    ..The aim of this study is to investigate the influence of donor factors on renal allograft outcome in a homogeneous cohort of 518 patients transplanted in a single centre over a 9 year period...
  62. ncbi Corticosteroid-free immunosuppression with tacrolimus, mycophenolate mofetil, and daclizumab induction in renal transplantation
    Lionel Rostaing
    Multiorgan Transplant Unit, Rangueil University Hospital, 31059 Toulouse, France
    Transplantation 79:807-14. 2005
    ..We investigated whether a corticosteroid-free tacrolimus (Tac)/mycophenolate mofetil (MMF) regimen, in combination with daclizumab (Dac) induction therapy, provides adequate immunosuppression after renal transplantation...
  63. ncbi Development and validation of an immunosuppressant therapy adherence barrier instrument
    Marie A Chisholm
    University of Georgia College of Pharmacy, Medical College of Georgia School of Medicine, Augusta, GA 30912, USA
    Nephrol Dial Transplant 20:181-8. 2005
    ..To decrease allograft rejection as a result of non-adherence to immunosuppressant therapy (IST), a valid and reliable instrument that measures solid organ transplant patients' adherence barriers is needed...
  64. ncbi Autologous fat transfer for facial recontouring: is there science behind the art?
    Matthew R Kaufman
    Division of Plastic and Reconstructive Surgery, University of California, Los Angeles, CA 90095, USA
    Plast Reconstr Surg 119:2287-96. 2007
    ..Clinical use of autologous fat grafts for facial soft-tissue augmentation has grown in popularity in the plastic surgery community, despite a perceived drawback of unpredictable results...
  65. ncbi Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response
    Maria Koulmanda
    Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:525-30. 2004
    ....
  66. ncbi Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival
    Jianping Li
    Centre Hospitalier Universitaire Vaudois, BH10, Lausanne 1011, Switzerland
    Am J Physiol Heart Circ Physiol 293:H3415-23. 2007
    ..IDO gene transfer into the donor heart attenuates acute cardiac allograft rejection. Regulation of tryptophan catabolism by means of IDO overexpression may be a useful approach in heart transplantation...
  67. ncbi Development and evaluation of a novel decellularized vascular xenograft
    B S Conklin
    School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30322, USA
    Med Eng Phys 24:173-83. 2002
    ..This study provides a new strategy to develop a small-caliber vascular graft with excellent mechanical properties, antithrombogeneity, and tissue compatibility...
  68. ncbi Contribution of donor age to the recent decrease in patient survival among HCV-infected liver transplant recipients
    Marina Berenguer
    Hepatogastroenterology Service, Hospital Universitario La Fe, Avenida Campanar 21, 46009 Valencia, Spain
    Hepatology 36:202-10. 2002
    ..In conclusion, patient survival is lower among HCV+ recipients than among HCV- ones and has been decreasing in recent years. The aging of donors is a major contributor to this worse outcome...
  69. ncbi The introduction of MELD-based organ allocation impacts 3-month survival after liver transplantation by influencing pretransplant patient characteristics
    Tobias J Weismüller
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Transpl Int 22:970-8. 2009
    ..Reduced 3-month survival was associated with longer surgery duration, higher creatinine and urea likely reflecting higher recipient morbidity. Survival probability should be incorporated into MELD-based graft allocation...
  70. pmc Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants
    Andrew M Cameron
    Dumont UCLA Liver Transplant Center, and Department of Surgery, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Ann Surg 243:748-53; discussion 753-5. 2006
    ..This work aimed to identify factors that impact survival outcomes for extended criteria donors (ECD) and developed an ECD scoring system to facilitate graft-recipient matching and optimize utilization of ECDs...
  71. pmc New insights on OX40 in the control of T cell immunity and immune tolerance in vivo
    Xiang Xiao
    Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 188:892-901. 2012
    ..Our data reveal a novel role for OX40 in promoting immune tolerance and may have important clinical implications...
  72. ncbi Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery
    Michael S Conte
    Division of Vascular Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Vasc Surg 43:742-751; discussion 751. 2006
    ....
  73. ncbi Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)
    Martin J Hoogduijn
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Transplantation 90:124-6. 2010
    ..Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway...
  74. pmc Tolerogenic dendritic cells and their role in transplantation
    Mohamed Ezzelarab
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1540, Pittsburgh, PA 15261, USA
    Semin Immunol 23:252-63. 2011
    ..Evaluation of technical and therapeutic logistic issues is an important next step prior to the application of tolerogenic DC in clinical organ transplantation...
  75. pmc Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts
    Ping Yu
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1457, USA
    Immunology 127:500-11. 2009
    ....
  76. ncbi Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection
    Benjamin D Ehst
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA
    Am J Transplant 3:1355-62. 2003
    ....
  77. ncbi alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months
    Yau Lin Tseng
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Transplantation 80:1493-500. 2005
    ..The recent generation of alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs has allowed investigation of the survival of GalT-KO pig organs in nonhuman primates...
  78. ncbi The T helper 17-regulatory T cell axis in transplant rejection and tolerance
    Peter Mitchell
    Department of Nephrology and Transplantation, King s College London, Guy s Hospital, London, UK
    Curr Opin Organ Transplant 14:326-31. 2009
    ..However, Tregs can be subverted by inflammatory conditions, resulting in a T helper 17 (Th17) cell response. This review looks at the relationship between Tregs and Th17 cells...
  79. ncbi Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation
    Vincenzo Mirenda
    Departments of Immunology, Histopatology, and Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    J Am Soc Nephrol 15:987-97. 2004
    ..Similarly treated AUG DC had no effect, confirming the privileged status of F1 cells in the induction of indirect pathway regulation...
  80. pmc The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin
    M Halberstadt
    Department of Ophthalmolgy, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Br J Ophthalmol 86:646-52. 2002
    ..To evaluate the outcome of corneal grafting in patients with stromal keratitis of herpetic (HSK) and non-herpetic origin, using predefined diagnostic criteria and standardised postoperative therapeutic strategies...
  81. pmc Increased numbers of low-oxygenated pancreatic islets after intraportal islet transplantation
    Richard Olsson
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    Diabetes 60:2350-3. 2011
    ..No previous study has measured the oxygenation of intraportally transplanted islets, although recent data suggest that insufficient engraftment may result in hypoxia and loss of islet cells...
  82. ncbi High dose of antithrombin III induces indefinite survival of fully allogeneic cardiac grafts and generates regulatory cells
    Osamu Aramaki
    Department of Surgery, Nihon University, Tokyo, Japan
    Transplantation 75:217-20. 2003
    ..The authors investigated whether antithrombin III (AT-III) could induce unresponsiveness to alloantigens...
  83. ncbi Comparison of short tandem repeat and variable number tandem repeat genetic markers for quantitative determination of allogeneic bone marrow transplant engraftment
    S A Schichman
    Pathology and Laboratory Medicine Service, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Bone Marrow Transplant 29:243-8. 2002
    ..This study demonstrates that STR-based human identity testing kits are well suited for engraftment analysis...
  84. ncbi Factors contributing to acute rejection in renal transplantation: the role of noncompliance
    P E Morrissey
    Division of Organ Transplantation and Medical Statistics, Rhode Island Hospital, Brown Medical School, 593 Eddy Street APC 921, Providence, RI 02903, USA
    Transplant Proc 37:2044-7. 2005
    ..Future strategies to improve compliance, including increased vigilance in high-risk patient groups, frequent medication review, and laboratory testing, should be encouraged...
  85. pmc Overexpression of thioredoxin in islets transduced by a lentiviral vector prolongs graft survival in autoimmune diabetic NOD mice
    Feng Cheng Chou
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Biomed Sci 16:71. 2009
    ..We hypothesized that the overexpression of TRX in islets would prolong islet graft survival when transplanted into diabetic non-obese diabetic (NOD) mice.
  86. pmc Liver graft exposure to carbon monoxide during cold storage protects sinusoidal endothelial cells and ameliorates reperfusion injury in rats
    Atsushi Ikeda
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Liver Transpl 15:1458-68. 2009
    ..In conclusion, CO delivery to excised liver grafts during cold preservation efficiently ameliorates SEC damage and hepatic I/R injury...
  87. pmc Focal C4d+ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival
    R L Kedainis
    Department of Internal Medicine, Renal Division, Washington University, St Louis, MO, USA
    Am J Transplant 9:812-9. 2009
    ..014), but not when compared to the focal C4d+ group. There was a clear trend toward worse graft survival in patients with focal C4d+ in this time interval, but focal C4d+ compared to both diffuse C4d+ and C4d-groups ..
  88. ncbi Melatonin prolongs islet graft survival in diabetic NOD mice
    Gu Jiun Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Pineal Res 47:284-92. 2009
    ..The mean islet graft survival time was 7.33 +/- 1.51 and 7.75 +/- 2...
  89. ncbi Selective cyclooxygenase 2 inhibitor induces indefinite survival of fully allogeneic cardiac grafts and generates CD4+ regulatory cells
    Takeshi Yokoyama
    Department of Surgery of Nihon University School of Medicine, Tokyo, Japan
    J Thorac Cardiovasc Surg 130:1167-74. 2005
    ..We investigated ability of a cyclooxygenase 2 inhibitor to inhibit alloimmune response in a murine cardiac transplantation model...
  90. ncbi Do mesenchymal stem cells play a role in vocal fold fat graft survival?
    V Lo Cicero
    Cell Factory, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, Milan, Italy
    Cell Prolif 41:460-73. 2008
    ....
  91. ncbi Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation
    Sanja Cabric
    Division of Clinical Immunology, Department of Oncology, Radiology, and Clinical Immunology, The Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Diabetes 56:2008-15. 2007
    ..To avoid systemic treatment, the aim of the present study was to render the islet graft blood biocompatible by applying a continuous heparin coating to the islet surface...
  92. ncbi Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice
    Udo Bartsch
    Department of Ophthalmology, University Medical Centre Hamburg Eppendorf, 20246 Hamburg, Germany
    Exp Eye Res 86:691-700. 2008
    ....
  93. ncbi Risk factors for corneal graft failure and rejection in penetrating keratoplasty
    K Inoue
    Department of Ophthalmology, University of Tokyo, School of Medicine, Tokyo, Japan
    Acta Ophthalmol Scand 79:251-5. 2001
    ..To evaluate risk factors for graft failure and allograft rejection after penetrating keratoplasty (PK)...
  94. ncbi Clinical islet transplantation: advances and immunological challenges
    Camillo Ricordi
    University of Miami School of Medicine, Diabetes Research Institute, Miami, Florida 33136, USA
    Nat Rev Immunol 4:259-68. 2004
  95. ncbi Transplants of human mesenchymal stem cells improve functional recovery after spinal cord injury in the rat
    Dasa Cizkova
    Institute of Neurobiology, Center of Excellence, SAS, Soltesovej 4, Kosice, 04001, Slovakia
    Cell Mol Neurobiol 26:1167-80. 2006
    ..In addition, low immunogenicity of hMSCs was confirmed by survival of donor cells without immunosuppressive treatment...
  96. pmc Therapeutic targeting of classical and lectin pathways of complement protects from ischemia-reperfusion-induced renal damage
    Giuseppe Castellano
    Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari, Italy
    Am J Pathol 176:1648-59. 2010
    ..Therefore, inhibition of these two pathways might represent a novel therapeutic approach in the prevention of delayed graft function in kidney transplant recipients...
  97. ncbi Dendritic cell physiology and function in the eye
    John V Forrester
    Section of Immunology and Infection, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Immunol Rev 234:282-304. 2010
    ..This approach has considerable potential for use in translational clinical therapy to prevent sight-threatening disease caused by ocular inflammation...
  98. pmc Revascularization of transplanted islets: can it be improved?
    Marcela Brissova
    Department of Medicine, Division of Diabetes, Endocrinology, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 57:2269-71. 2008
  99. ncbi Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival
    Timucin Taner
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, PA, USA
    Am J Transplant 5:228-36. 2005
    ..When infused 1 week before transplantation, these Rapa-DC significantly prolonged alloAg-specific heart graft survival. This effect was reversed by systemic IL-2 administration but enhanced by either repeated infusion of the ..
  100. ncbi Mesenchymal stem cells are present in peripheral blood and can engraft after allogeneic hematopoietic stem cell transplantation
    Eva Maria Villarón
    Hematology Dept, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
    Haematologica 89:1421-7. 2004
    ..In the present study we have analyzed whether, within the allogeneic transplantation setting, MSC are of host or donor origin...
  101. ncbi Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Neurosci Res 69:966-75. 2002
    ..This being the case, they may constitute appropriate vectors for cell-based remyelination strategies...

Research Grants66

  1. LIVER PRESERVATION FOR TRANSPLANTATION
    John J Lemasters; Fiscal Year: 2012
    ..after liver transplantation and that pharmacological inhibition of JNK decreases graft injury and improves graft survival. Two JNK isoforms, JNK1 and JNK2, are expressed in liver...
  2. Towards Induction of Cell Transplant Tolerance
    Lina Lu; Fiscal Year: 2013
    ..involved, we have created a HSC/islet co-transplantation model in chemically-induced diabetic mice, in which graft survival can be simply monitored by serum glucose levels...
  3. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..in DM and provide tools to measure responsiveness to new therapies and evaluate efficiency of islet graft survival. PHS 398/2590 (Rev...
  4. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..With improved immunosuppression and surgical technique, graft survival has significantly increased...
  5. ACTIVATION OF XENOGENEIC ENDOTHELIUM TO RESIST INJURY
    Agustin P Dalmasso; Fiscal Year: 2010
    ..carrying the IL-4 gene, or an irrelevant gene as control, and then transplanted into rats for studies of graft survival, histology, and gene expression and activation...
  6. GRAFT REJECTION AND DIRECT VERSUS INDIRECT RECOGNITION
    PETER SCOTT HEEGER; Fiscal Year: 2013
    ..We will gain new information that has the potential to guide therapeutic inventions aimed a prolonging graft survival, first in animal models and ultimately in humans...
  7. Sphingosine 1 phosphate receptors 1 and 3 as novel targets in transplantation
    Amandeep Bajwa; Fiscal Year: 2013
    ..DCs lacking the S1P3 are unable to induce an innate immune response after kidney IRI and lack of S1P3 prolongs graft survival in skin and heart transplantation studies...
  8. VIRAL INFECTION INFLUENCE ON TRANSPLANTATION TOLERANCE
    DALE LESLIE GREINER; Fiscal Year: 2013
    ..The goal of these studies is to discover mechanisms that determine graft survival in the face of infection and innate immune activation...
  9. Measurement of Renal Viscoelastic Properties with Ultrasound
    MATTHEW WILLIAM URBAN; Fiscal Year: 2013
    ..Patient and renal graft survival rates have increased over the past five decades, but long-term survival of grafts is still an issue...
  10. Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection
    Anupam Agarwal; Fiscal Year: 2010
    ..inflammation and neointimal proliferation would effectively ameliorate chronic vascular rejection and prolong graft survival, limiting the need for subsequent retransplantation or the return to dialysis...
  11. EMBRYONIC STEM CELLS INDUCE SPECIFIC GRAFT TOLERANCE
    Nicholas Zavazava; Fiscal Year: 2012
    ..Although first year graft survival rates are 90 %, this initial high success rate drastically declines to less than 50 % within 10 years...
  12. NPY,Neurovascular Niches and Stress-Induced Remodeling of Adipose Tissue
    John W Osborn; Fiscal Year: 2013
    ..In human Y2Rpositive fat grafted into nude mice, elevated NPY induces vascularization and long-lasting graft survival. These and new data of epigenetic regulation of NPY, prompted us to hypothesize that stress epigenetically ..
  13. RAGE Mediated Mechanisms of Islet Amyloid Polypeptide Cytotoxicity in Type 2 Diab
    Andisheh Abedini; Fiscal Year: 2011
    ..transplantation, and we have recently shown that prevention of islet amyloid can contribute significantly to graft survival. My goals are to define the nature of the toxic species produced during amyloid formation by h-amylin and to ..
  14. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    ..in heart, kidney, and liver transplantation, where HLA-G expression is associated with graft survival. However, the role of HLA-G in lung transplant survival has never been studied, and the relationship between ..
  15. Delayed Tolerance Induction in Living Related Donor Renal Transplant Recipients
    Suzanne T Ildstad; Fiscal Year: 2012
    ..drugs in clinical transplantation is expensive and results in significant morbidity and limitation in graft survival. Donor specific transplant tolerance would eliminate the need for drug- based immunosuppression, but has been ..
  16. Anti-HLA Antibody Activation of Endothelial Cells in Cardiac Transplantation
    Elaine F Reed; Fiscal Year: 2010
    ..This suggests that lower levels of anti-HLA antibody binding to HLA may be beneficial to graft survival by activating survival signaling pathways that promote graft accommodation...
  17. Molecular pathways leading to chronic graft dysfunction
    VALERIA RAQUEL MAS; Fiscal Year: 2012
    ..initial molecular events that predispose and trigger CAN represents the best design for improving long-term graft survival rates...
  18. The Role of Heme Oxygenase-1 in the Immune Response
    James F George; Fiscal Year: 2013
    ..expression in DCs for kidney allografts by testing the hypothesis that HO-1 overexpressing DC will prolong graft survival, improve renal function and alleviate histological features of CAN...
  19. BK Virus Receptor and polyomavirus nephropathy
    Andrey Sorokin; Fiscal Year: 2012
    ..provide the basis for a novel strategy for therapeutical intervention in BKN, ultimately improving long-term graft survival after renal transplantation...
  20. Donor Stem Cells, Campath, T/B Cell Regulation In HLA-Identical Renal Transplants
    Joshua Miller; Fiscal Year: 2010
    ..immunity, in 20 HLAgi sibling donor / recipient renal transplant pairs [current nation-wide 10-year graft survival is between 65-70% including 20% (immunosuppression-related) mortality]...
  21. ATF3 and iNOS in Islet Distruction and Graft Rejection
    Tsonwin Hai; Fiscal Year: 2010
    ..be used to determine whether the lack of ATF3 and/or iNOS alleviate(s) any of the main obstacles for islet graft survival: primary non-function (by syngeneic model), allo-immunity (by allogeneic model) andauto-immunity (by auto-..
  22. Treatment of Transplant Reperfusion with CD47 antibody
    PAMELA ANN TOY-MANNING; Fiscal Year: 2013
    ..and is responsible for delayed graft function, initial graft failure and contribtes to poor long-term graft survival, thus representing an area of significant unmet medical need...
  23. Role of T Regulatory Cells in Preventing Human BOS
    Aric L Gregson; Fiscal Year: 2013
    ..The research plan is focused on lymphocytes, chemokines, cytokines and long-term graft survival. Lung transplantation is a therapeutic option for end-stage lung disorders...
  24. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn J Pelletier; Fiscal Year: 2010
    ..number of organs transplanted per donor (OTPD), decreased kidney DGF rates (8%) and liver recipient and graft survival rates similar to DBD donors...
  25. Anti-MHC Effects on Endothelium
    Elaine F Reed; Fiscal Year: 2013
    ..On the other hand, high levels of antibody binding may have a detrimental effect on graft survival by upregulating FGFR expression, stimulating cell proliferation and increasing risk for development of ..
  26. Novel Urinary Proteomic Biomarkers for Acute Renal Transplant Rejection
    Minnie M Sarwal; Fiscal Year: 2010
    ..b>Graft survival after kidney transplantation, the treatment of choice for children with end stage kidney disease, is ..
  27. Urinary Proteome Monitoring for Transplant Injury
    Minnie M Sarwal; Fiscal Year: 2013
    ..Kidney transplantation is the treatment of choice for children with end stage kidney disease. Graft survival is limited by the accrual of different injuries such as acute rejection (AR), chronic allograft nephropathy (..
  28. Solid Organ Transplantation in HIV: Multi-Site Study
    Peter G Stock; Fiscal Year: 2010
    ..that is powered to test the hypothesis that HIV+ liver and kidney transplant recipients will have patient and graft survival rates equivalent to other patient groups without HIV infection currently considered acceptable transplant ..
  29. Improving Primordial Follicle Survival After Transplantation of Cryopreserved Hum
    Kutluk H Oktay; Fiscal Year: 2012
    ..We will determine whether S1P improves graft survival and neovascularization by primordial follicle survival, histological and molecular assessment of ..
  30. Individualizing Therapy for Kidney and Heart Transplant Recipients
    PETER SCOTT HEEGER; Fiscal Year: 2013
    ..will lower PRA, diminish the waiting time to heart transplantation and result in acceptable 1 year graft survival and function...
  31. Right Lobe Living Donor Liver Transplantation in Adults
    PAUL HIDEYO HAYASHI; Fiscal Year: 2010
    ..Overall one-year patient and graft survival for both CADLT and LDLT are 90-95% and 77-85% respectively...
  32. Imaging of Cardiac Transplant Rejection
    Matthias Nahrendorf; Fiscal Year: 2013
    ..To monitor graft survival, recipients endure frequent invasive endomyocardial biopsies which carry a significant risk of complication ..
  33. THE IMMUNOBIOLOGY OF CORNEAL ALLOGRAFTS
    Jerry Niederkorn; Fiscal Year: 2013
    ..In the case of MHC + multiple minor histocompatibility (H)-mismatched grafts, IFN-y is required for graft survival. By contrast, in MHC-matched, minor H mismatched grafts IFN-y promotes corneal allograft rejection...
  34. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2013
    ..Molecular blockade of the lymphatic factors promotes HR graft survival. This proposal is based on the most recent advances in technology and lymphatic research, and a large amount ..
  35. Novel Costimulation Blockers in Islet Transplantation
    Scott M Krummey; Fiscal Year: 2013
    ..been extensively utilized in our lab, we will investigate the cellular mechanisms of induction of long-term graft survival by these dAbs...
  36. NK Cell Interactions in Transplantation
    SHERI KRAMS; Fiscal Year: 2009
    ..Furthermore, depletion of NK cells results in decreased levels of IFN-y and prolonged graft survival. Based on these data we suggest a model in which surgical stress and ischemia/reperfusion injury stimulate the ..
  37. Studies of Pediatric Liver Transplantation
    Anne S Lindblad; Fiscal Year: 2010
    ..and follow trends and indications for transplant, transplantation techniques, and outcomes such as patient and graft survival, rejection incidence, growth parameters, immunosuppressive therapy and complications...
  38. Consequences of Aging on Immune Response and Transplant Outcome
    STEFAN GUNTHER TULLIUS; Fiscal Year: 2013
    ..clinical study that older renal transplant recipients had less acute rejections and a better (death censored) graft survival. In contrast, engraftment of older organs had been linked with significantly more acute rejections...
  39. Treg suppression of islet allograft rejection
    Ramakrishna Vankayalapati; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Despite extensive studies on Treg cells related to graft survival in many animal models, adoptive transfer of Treg cells alone remains ineffective in inducing long-term graft ..
  40. Composite Allografting for Promoting Survival of Corneal Transplants
    DANIEL RAPHAEL SABAN; Fiscal Year: 2010
    ..I therefore hypothesize that this strategy will diminish allosensitization to graft endothelium and promote graft survival in a model of high-risk transplantation...
  41. Use of Discarded Organs for Preparation of Liver Grafts
    BASAK ELIF UYGUN; Fiscal Year: 2012
    ..or >16hrs cold ischemia) is known to lead to complications in the long term with significantly reduced graft survival at 6 months...
  42. University Health Network's Application to Join the A2ALL Consortium
    David R Grant; Fiscal Year: 2013
    ..Our 5-year graft survival rates are >80% comparable to the results of deceased donor transplantation at our center We have been ..
  43. TIM molecules and the innate: adaptive interface in alloimmunity
    Nader Najafian; Fiscal Year: 2013
    ..The relative contribution of these functions to the marked effect of anti-TIM-4 on graft survival is unknown and is the central focus of this proposal...
  44. THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTION
    Daniel Kreisel; Fiscal Year: 2013
    ..A major obstacle to the success of lung transplantation is ischemia reperfusion injury. We propose to study how ischemia reperfusion injury impacts lung graft survival utilizing a novel mouse model.
  45. Dendritic Cells, Rapamycin and Transplant Tolerance
    Angus W Thomson; Fiscal Year: 2010
    ..MHC-mismatched organ graft recipients with host-derived RAPA-DC, pulsed with donor Ag, promotes donor-specific graft survival. Repeated infusion, or a short course of minimal immunosuppression, enhances long-term transplant survival, ..
  46. Lipid Mediators in Pancreatic Islet Dysfunction
    Jerry L Nadler; Fiscal Year: 2010
    ..3) Effect of 12LO gene targeting on improving islet graft survival will be studied utilizing spontaneously diabetic NOD mice as recipients...
  47. Constitutive and Agent-Based Multiscale Models to Improve Vein Graft Survival
    Rongling Wu; Fiscal Year: 2013
    ..will move forward into a large animal validation model and translated into a therapeutic tool to improve vein graft survival. Approach: Packaging a lentivirus delivery vehicle with a siRNA construct, we will utilize a rabbit vein ..
  48. Intragraft expression to Predict Future GFR Decline in Kidney Transplantation
    Mark D Stegall; Fiscal Year: 2013
    ..lead to the development of innovative management protocols after transplantation that will improve long-term graft survival. RELEVANCE: The reasons why kidney transplants do not last indefinitely is unclear...
  49. Role of complement in brain death induced injury to donor hearts
    Stephen Tomlinson; Fiscal Year: 2010
    ..recipient) will provide protection from inflammation and injury, and as a consequence, will improve long-term graft survival due to decreased graft immunogenicity and host alloresponsiveness...
  50. Indoleamine 2,3-dioxygenase protective role in lung transplantation
    Gary A Visner; Fiscal Year: 2010
    ..metabolism with immune modulating and potentially anti-fibrotic properties that may provide long-term graft survival effects...
  51. Immune tolerance in humanized translational models to cure diabetes
    Brian T Fife; Fiscal Year: 2013
    ..two-photon imaging, and 3) Characterize and determine the functional and biological immune response against transplanted islets following antigen specific tolerance induction in the humanized model for long term islet graft survival.
  52. Perfusion preservation solution for recovery of Donation by Cardiac Death livers
    Charles Y Lee; Fiscal Year: 2012
    ..Studies show that HMP can improve graft survival in animal models...
  53. Renal transplant and subclinical herpesvirus infection
    Jodi Smith; Fiscal Year: 2009
    ..of CAN, these studies may be instrumental in developing preventive and/or treatment measures that can improve graft survival thereby greatly decreasing morbidity and mortality in renal transplant patients...
  54. Effects of Lymphangiogenesis Blockade on Skin Allograft Rejection
    GILLES A BENICHOU; Fiscal Year: 2013
    ..prevents donor passenger leukocyte trafficking, reduced the anti-donor immune response and prolonged alloskin graft survival for up to 50 days (while non-treated mice rejected their grafts after 10 days)...
  55. Therapeutic Targets for Chronic Allograft Rejection
    D Keith Bishop; Fiscal Year: 2013
    ..will be performed in the mouse cardiac allograft model where transient depletion of CD4+ cells prolongs graft survival yet all manifestations of CR develop. Aim 1 will test the role of recipient vs...
  56. Ex Vivo Expansion of Human Limbal Stem Cells for Transplantation
    Sophie Deng; Fiscal Year: 2013
    ..expansion efficiency of the stem/progenitor cell population in culture corresponds to a better long-term graft survival. The most efficient expansion method requires mouse 3T3 feeder cells which are grown using calf serum and are ..
  57. Chemokines and T Cell Recruitment in High Risk Corneal Allograft Rejection
    Victor L Perez; Fiscal Year: 2013
    ..Although the in vivo neutralization of CXCL1/KC results in increased graft survival, our recent data shows that neutralization of CXCL10/IP10 causes a faster and robust rejection...
  58. Migration and Trafficking in Tolerance 10/07
    Jonathan S Bromberg; Fiscal Year: 2012
    ..The ability to define these interactions and achieve tolerance is important for achieving good graft survival and patient survival for transplant recipients.
  59. Induction and Migration of Regulatory T Cells
    Jonathan S Bromberg; Fiscal Year: 2013
    ..The ability to define these interactions and achieve tolerance is important for achieving good graft survival and patient survival for transplant recipients.
  60. ENDOSCOPIC BIOPSY OF ISLET TRANSPLANTS IN THE GASTRIC SUBMUCOSAL SPACE IN PIGS
    Hidetaka Hara; Fiscal Year: 2012
    ..g., blood glucose level, insulin requirement). This information will allow steps to be taken to enhance islet graft survival (e.g...
  61. Potential to Immunocloak Renal Allografts
    Lauren Brasile; Fiscal Year: 2010
    ..protective mechanism(s) will help to develop treatment strategies that could one day lead to enhanced graft survival without the traditional need for chronic systemic immunosuppression...
  62. Foxp3+ Treg Cells &Primary Graft Dysfunction in Clinical Lung Tx Recipients
    WAYNE WILLIAM HANCOCK; Fiscal Year: 2013
    ..liver, but unfortunately the results of lung transplantation have lagged considerably in terms of patient and graft survival rates...
  63. Enhanced Cryoprecipiate in Wound Healing
    Edward Shanbrom; Fiscal Year: 2007
    ..Adhesion, revascularization and reepithelialization of these grafts are of great importance for graft survival and are the focus of the proposed study...
  64. Improving Kidney Transplant Outcome with a Novel Complement Inhibitor
    SHELLEY MAVES; Fiscal Year: 2007
    ..Commonly used immuno-suppressants that are required for long term graft survival are nephrotoxic and actually exacerbate DGF, underscoring the need for a new approach...
  65. SEQUESTER HYALURONAN--LIMIT CHRONIC ALLOGRAFT REJECTION
    RASHMIN SAVANI; Fiscal Year: 1999
    ..development of vascular stenosis and organ fibrosis, is one of the major impediments to successful long-term graft survival. Thus, given that the half life of a cadeveric kidney transplant is eight years, children receiving ..
  66. Outcomes of Hepatitis C Following Liver Transplantation
    A Shakil; Fiscal Year: 2004
    ..With the continued shortage of donor organs, it is crucial to develop strategies to promote long-term graft survival. We hypothesize that in the immune suppressed transplant recipient, HCV genetic features play a dominant role ..