histocompatibility

Summary

Summary: The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.

Top Publications

  1. ncbi HLA matching in allogeneic stem cell transplantation
    Effie W Petersdorf
    University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Division of Clinical Research, Seattle, Washington 98109, USA
    Curr Opin Hematol 11:386-91. 2004
  2. ncbi Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genes
    John A Hansen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Ave N, D2 100, P O Box 19024, Seattle, WA 98109 1024, USA
    Immunol Res 41:56-78. 2008
  3. ncbi Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation
    Dao Pei Lu
    Peking University Institute of Hematology, 11 Xizhimen South Street, Beijing 100044, China
    Blood 107:3065-73. 2006
  4. ncbi Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome
    Neal Flomenberg
    Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 104:1923-30. 2004
  5. pmc Risk assessment in haematopoietic stem cell transplantation: histocompatibility
    Effie W Petersdorf
    Department of Medicine, University of Washington, 1959 Northeast Pacific, Seattle, WA 98195, USA
    Best Pract Res Clin Haematol 20:155-70. 2007
  6. ncbi Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide
    L Luznik
    Division of Hematopoiesis, Hematologic Malignancies, and Pediatric Oncology, Johns Hopkins Oncology Center, Baltimore, MD, USA
    Blood 98:3456-64. 2001
  7. ncbi Histocompatibility reaction in tissue and cells of the marine sponge Suberites domuncula in vitro and in vivo: central role of the allograft inflammatory factor 1
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, 55099 Mainz, Germany
    Immunogenetics 54:48-58. 2002
  8. doi The relevance of minor histocompatibility antigens in solid organ transplantation
    Miranda Dierselhuis
    Department of Immunohematology and Bloodtranfusion, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Organ Transplant 14:419-25. 2009
  9. pmc Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes
    Yishai Ofran
    Division of Hematologic Malignancies, Cancer Vaccine Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 16:1642-51. 2010
  10. ncbi Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenes
    Z Jiang
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    Blood 98:390-7. 2001

Research Grants

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  2. Tibor T Glant; Fiscal Year: 2016
  3. Tibor T Glant; Fiscal Year: 2014
  4. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
  5. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
  6. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2013
  7. Jakub Tolar; Fiscal Year: 2016
  8. Matthew B Grisham; Fiscal Year: 2015
  9. Irritable bowel syndrome-diarrhea: the role of gluten intolerance and HLA-DQ2
    MICHAEL L CAMILLERI; Fiscal Year: 2010
  10. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013

Detail Information

Publications275 found, 100 shown here

  1. ncbi HLA matching in allogeneic stem cell transplantation
    Effie W Petersdorf
    University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Division of Clinical Research, Seattle, Washington 98109, USA
    Curr Opin Hematol 11:386-91. 2004
    ..The goal of this review is to summarize new findings in the field of immunogenetics and HCT from unrelated donors using myeloablative conditioning regimens...
  2. ncbi Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genes
    John A Hansen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Ave N, D2 100, P O Box 19024, Seattle, WA 98109 1024, USA
    Immunol Res 41:56-78. 2008
    ....
  3. ncbi Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation
    Dao Pei Lu
    Peking University Institute of Hematology, 11 Xizhimen South Street, Beijing 100044, China
    Blood 107:3065-73. 2006
    ..In summary, HCT performed with related HLA-mismatched donors is a feasible approach with acceptable outcomes...
  4. ncbi Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome
    Neal Flomenberg
    Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 104:1923-30. 2004
    ..When clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome...
  5. pmc Risk assessment in haematopoietic stem cell transplantation: histocompatibility
    Effie W Petersdorf
    Department of Medicine, University of Washington, 1959 Northeast Pacific, Seattle, WA 98195, USA
    Best Pract Res Clin Haematol 20:155-70. 2007
    ..Increased availability of HCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of NK-KIR genes in transplantation...
  6. ncbi Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide
    L Luznik
    Division of Hematopoiesis, Hematologic Malignancies, and Pediatric Oncology, Johns Hopkins Oncology Center, Baltimore, MD, USA
    Blood 98:3456-64. 2001
    Treatment of leukemia by myeloablative conditioning and transplantation of major histocompatibility complex (MHC)-mismatched stem cells is generally avoided because of the high risk of graft rejection or lethal graft-versus-host disease (..
  7. ncbi Histocompatibility reaction in tissue and cells of the marine sponge Suberites domuncula in vitro and in vivo: central role of the allograft inflammatory factor 1
    Werner E G Muller
    Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, 55099 Mainz, Germany
    Immunogenetics 54:48-58. 2002
    ....
  8. doi The relevance of minor histocompatibility antigens in solid organ transplantation
    Miranda Dierselhuis
    Department of Immunohematology and Bloodtranfusion, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Organ Transplant 14:419-25. 2009
    Disparities in minor histocompatibility antigens between HLA-matched organ and hematopoietic stem cell donors and recipients create the risks of graft failure and graft-versus-host disease (GvHD) respectively...
  9. pmc Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes
    Yishai Ofran
    Division of Hematologic Malignancies, Cancer Vaccine Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 16:1642-51. 2010
    Donor T cells respond to minor histocompatibility antigens (mHA), resulting in both graft-versus-host disease and graft versus leukemia after allogeneic hematopoietic stem cell transplantation...
  10. ncbi Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenes
    Z Jiang
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    Blood 98:390-7. 2001
    ..the role of CD4-mediated antihost cytotoxicity in a GVH response is further examined across a complete major histocompatibility complex class I/II mismatch...
  11. pmc Isolation and characterization of a protochordate histocompatibility locus
    Anthony W De Tomaso
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 438:454-9. 2005
    b>Histocompatibility--the ability of an organism to distinguish its own cells and tissue from those of another--is a universal phenomenon in the Metazoa...
  12. ncbi The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies
    S P Cobbold
    Division of Immunology, University of Cambridge, GB
    Eur J Immunol 20:2747-55. 1990
    ..Where donor and recipient were incompatible across the whole major histocompatibility complex, specific tolerance could be achieved by using a combination of depleting followed by non-depleting ..
  13. ncbi Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes
    D W Bailey
    Transplantation 11:325-7. 1971
  14. ncbi Recognition and rejection of self in plant self-incompatibility: comparisons to animal histocompatibility
    June B Nasrallah
    Department of Plant Biology, Cornell University, Ithaca, NY 14850, USA
    Trends Immunol 26:412-8. 2005
    ....
  15. ncbi Comparing morbidity and mortality of HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative and myeloablative conditioning: influence of pretransplantation comorbidities
    Mohamed L Sorror
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109, USA
    Blood 104:961-8. 2004
    ..After adjustment for pretransplantation differences between the 2 patient groups, the hazard ratio was 3.0 (P=.04). Multivariate analyses showed higher pretransplantation comorbidity scores to result in increased toxicity and mortality...
  16. ncbi Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: implications for stem cell transplantation and immunotherapy
    Rob M Verdijk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Blood 103:1961-4. 2004
    ..We analyzed whether pregnancy primes for minor histocompatibility (H) antigens...
  17. pmc Invertebrate allorecognition: the origins of histocompatibility
    Larry J Dishaw
    Department of Pediatrics, University of South Florida, 830 First Street South, St Petersburg, FL 33701, USA
    Curr Biol 19:R286-8. 2009
    Alloimmune specificity and histocompatibility, driven by genetic polymorphism, are ancient determinants of self-/non-self-recognition...
  18. ncbi Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation
    Tuna Mutis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Blood 100:547-52. 2002
    ..We investigated the feasibility of this strategy using the hematopoietic system-specific minor histocompatibility antigen HA-1, which is known to induce HLA-A2-restricted CTLs...
  19. ncbi A significant role for histocompatibility in human islet transplantation
    T Mohanakumar
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 82:180-7. 2006
    ..The purpose of this study was to determine the role of pretransplant sensitization to human leukocyte antigen (HLA) in islet transplantation...
  20. ncbi Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers
    M C Bittencourt
    , , , France
    Blood 98:224-30. 2001
    ..Such a simple approach could be of interest in BM transplantation settings involving an important HLA donor/recipient disparity, a T-cell-depleted graft, or reduced conditioning regimen intensity...
  21. ncbi Cell adhesion and histocompatibility in sponges
    X Fernandez-Busquets
    Friedrich Miescher Institut, Basel, Switzerland
    Microsc Res Tech 44:204-18. 1999
    ..Important cases of cell adhesion are the phenomena involved in histocompatibility reactions...
  22. pmc Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts
    Ping Yu
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1457, USA
    Immunology 127:500-11. 2009
    Mixed chimerism has been shown to lead to prolonged major histocompatibility complex (MHC) disparate allograft survival and immune-specific tolerance; however, traditional conditioning regimes often involve myeloablation, which may pose a ..
  23. doi Definitions of histocompatibility typing terms: Harmonization of Histocompatibility Typing Terms Working Group
    Eduardo Nunes
    AABB, Bethesda, Maryland, USA
    Hum Immunol 72:1214-6. 2011
    b>Histocompatibility testing for stem cell and solid organ transplantation has become increasingly complex as newly discovered human leukocyte antigen (HLA) alleles are described...
  24. doi Definitions of histocompatibility typing terms
    Eduardo Nunes
    American Association of Blood Banks, Bethesda, MD, USA
    Blood 118:e180-3. 2011
    b>Histocompatibility testing for stem cell and solid organ transplantation has become increasingly complex as newly discovered HLA alleles are described...
  25. pmc Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations
    A Sanchez-Mazas
    University of Geneva, Geneva, Switzerland
    Int J Immunogenet 39:459-72; quiz 473-6. 2012
    ..All HLA-NET guidelines and tools are available through its website http://hla-net.eu...
  26. ncbi Major histocompatibility antigen expression on the bovine placenta: its relationship to abnormal pregnancies and retained placenta
    C J Davies
    Department of Veterinary Microbiology and Pathology and Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, P O Box 647040, Pullman, WA 99164 7040, USA
    Anim Reprod Sci 82:267-80. 2004
    In viviparous animals, regulation of expression of major histocompatibility complex (MHC) class I antigens by the trophoblast cells, which constitute the outermost layer of the placenta, seems to be critical for maternal immunological ..
  27. ncbi Treatment of streptozotocin-induced diabetes mellitus in rats by transplantation of islet cells from two major histocompatibility complex disparate rats in combination with intra bone marrow injection of allogeneic bone marrow cells
    Mitsuru Taira
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Transplantation 79:680-7. 2005
    ....
  28. doi Histocompatibility methods
    Kathryn Tinckam
    Departments of Laboratory Medicine and Pathobiology and Medicine, University of Toronto, Toronto ON, Canada M5G 1L5
    Transplant Rev (Orlando) 23:80-93. 2009
    Predicting humoral alloimmune potential in transplant recipients is the objective of histocompatibility testing and depends upon accurate donor typing and sensitive and specific testing for antibodies to human leukocyte antigen...
  29. doi Female-versus-male alloreactivity as a model for minor histocompatibility antigens in hematopoietic stem cell transplantation
    M Stern
    Department of Hematology, University Hospital, Basel, Switzerland
    Am J Transplant 8:2149-57. 2008
    H-Y encoded gene products were the first to be recognized as clinically relevant minor histocompatibility antigens...
  30. doi Xenogeneic immunosuppression of human umbilical cord mesenchymal stem cells in a major histocompatibility complex-mismatched allogeneic acute graft-versus-host disease murine model
    Juan Guo
    Department of Hematology, Shanghai Sixth People s Hospital, Shanghai, China
    Eur J Haematol 87:235-43. 2011
    ..Our study suggests that in vitro expanded HUCMSCs might be used to inhibit severe aGVHD effectively in allogeneic hematopoietic cell transplantation clinically...
  31. pmc Effects of histocompatibility and host immune responses on the tumorigenicity of pluripotent stem cells
    Ralf Dressel
    Department of Cellular and Molecular Immunology, University of Gottingen, Humboldtallee 34, 37073, Gottingen, Germany
    Semin Immunopathol 33:573-91. 2011
    ..This has to be considered when the results of experimental transplantation models are interpreted and even more when translation into clinics is planned...
  32. ncbi The role of major histocompatibility complex class I chain-related gene A antibodies in organ transplantation
    Yizhou Zou
    Transplantation Immunology Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390 8886, USA
    Curr Opin Organ Transplant 14:414-8. 2009
    Major histocompatibility complex class I chain-related gene A (MICA) antigens are expressed on the endothelium, they are polymorphic and have been shown to be recognized by antibodies produced by transplant recipients...
  33. ncbi fester, A candidate allorecognition receptor from a primitive chordate
    Spencer V Nyholm
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 25:163-73. 2006
    b>Histocompatibility in the primitive chordate, Botryllus schlosseri, is controlled by a single, highly polymorphic locus, the FuHC...
  34. pmc A hypervariable invertebrate allodeterminant
    Matthew L Nicotra
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511, USA
    Curr Biol 19:583-9. 2009
    ..Such encounters typically lead to a natural histocompatibility response in which colonies either fuse to become a single, chimeric colony or reject and aggressively ..
  35. pmc Impact of ABO-incompatible listing on wait-list outcomes among infants listed for heart transplantation in the United States: a propensity analysis
    Christopher S Almond
    Department of Cardiology, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Circulation 121:1926-33. 2010
    ..We sought to describe recent trends in ABO-I listing for US infants and to determine the impact of ABO-I listing on wait times and wait-list mortality...
  36. ncbi ABO-incompatible heart transplantation in infants
    L J West
    Department of Paediatrics, Hospital for Sick Children and University of Toronto, ON, Canada
    N Engl J Med 344:793-800. 2001
    ..This contraindication may not apply to newborn infants, who do not yet produce antibodies to T-cell-independent antigens, including the major blood-group antigens...
  37. pmc Identification of a colonial chordate histocompatibility gene
    Ayelet Voskoboynik
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 341:384-7. 2013
    b>Histocompatibility is the basis by which multicellular organisms of the same species distinguish self from nonself. Relatively little is known about the mechanisms underlying histocompatibility reactions in lower organisms...
  38. doi The candidate Fu/HC gene in Botryllusschlosseri (Urochordata) and ascidians' historecognition--an oxymoron?
    Buki Rinkevich
    Israel Oceanographic and Limnological Research, National Institute of Oceanography, Tel Shikmona, P O Box 8030, Haifa 31080, Israel
    Dev Comp Immunol 36:718-27. 2012
    ..Botryllus schlosseri this historecognition is governed at a single genetic locus, Fu/HC (for fusibility/histocompatibility), with hundreds of co-dominantly expressed alleles. Several years ago, De Tomaso et al...
  39. pmc The candidate histocompatibility locus of a Basal chordate encodes two highly polymorphic proteins
    Marie L Nydam
    Department of MCD Biology, University of California Santa Barbara, Santa Barbara, California, USA
    PLoS ONE 8:e65980. 2013
    ..Both genes are highly polymorphic and co-expressed on tissues involved in histocompatibility. In addition, polymorphisms on both genes correlate with outcome, although we have found a case in which it ..
  40. doi Molecular evolution of a polymorphic HSP40-like protein encoded in the histocompatibility locus of an invertebrate chordate
    Marie L Nydam
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Dev Comp Immunol 41:128-36. 2013
    ..While the majority of the Hsp40-L protein appears to evolve under purifying selection, a section of the C-terminal region likely experiences balancing/directional selection, characteristic of other allorecognition proteins. ..
  41. pmc 16th IHIW: international histocompatibility working group in hematopoietic cell transplantation
    E W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Int J Immunogenet 40:2-10. 2013
    The International Histocompatibility Working Group is a collaborative international effort to understand the HLA and non-HLA genetics of the transplantation barrier...
  42. doi Organ procurement and transplantation network/united network for organ sharing histocompatibility committee collaborative study to evaluate prediction of crossmatch results in highly sensitized patients
    Afzal Nikaein
    OPTN UNOS Histocompatibility Committee, Richmond, VA, USA
    Transplantation 87:557-62. 2009
    ..undertaken by the Organ Procurement and Transplantation Network/United Network for Organ Sharing (OPTN/UNOS) Histocompatibility Committee to evaluate the accuracy with which the detection of unacceptable human leukocyte antigen (HLA) ..
  43. pmc Genetics of graft-versus-host disease: the major histocompatibility complex
    Effie W Petersdorf
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States
    Blood Rev 27:1-12. 2013
    ..are presumed to be involved in GVHD, but the best characterized genetic system is that of the human major histocompatibility complex (MHC) located on chromosome 6...
  44. pmc The fester locus in Botryllus schlosseri experiences selection
    Marie L Nydam
    Division of Science and Mathematics, Centre College, Danville, KY 40422, USA
    BMC Evol Biol 12:249. 2012
    ..the genetic basis of allorecognition has rarely been characterized outside the well-known MHC (Major Histocompatibility Complex) in vertebrates and SI (Self-Incompatibility) in plants...
  45. ncbi Chronic spontaneous urticaria: epidemiological characteristics focusing on the histocompatibility profile and presence of antibodies
    Zamir Calamita
    Division of Allergy and Clinical Immunology of Marília Medical School FAMEMA, Marilia, Sao Paulo, Brazil
    Inflamm Allergy Drug Targets 12:8-11. 2013
    Understanding the etiopathogenesis of chronic spontaneous urticaria (CSU) remains a challenge. The clinical and laboratory characteristics relating to its histocompatibility profile and autoimmunity are constant research topics.
  46. doi Sea squirts and immune tolerance
    Anthony W De Tomaso
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Dis Model Mech 2:440-5. 2009
    ..reaction, which is controlled by a single, highly polymorphic locus called fuhc, reminiscent of major histocompatibility complex (MHC)-based allorecognition...
  47. doi Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation
    Eric Spierings
    Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Blood Marrow Transplant 19:1244-53. 2013
    ..Yet, the International Histocompatibility and Immunogenetics Workshops (IHIW) provide a collaborative platform to execute crucial large studies...
  48. ncbi Minor histocompatibility antigen HA-8 mismatch and clinical outcome after HLA-identical sibling donor allogeneic stem cell transplantation
    Arianne Perez-Garcia
    Haematologica 90:1723-4. 2005
    ..The presence of an HA-8 mismatch was associated with an increased risk of severe acute graft-versus-host disease and with a worse overall survival...
  49. doi Role of antithymocyte globulin and granulocyte-colony stimulating factor-mobilized bone marrow in allogeneic transplantation for patients with hematologic malignancies
    Xing Hua Chen
    Department of Hematology, Internal of Field Battle, Xinqiao Hospital, The Third Military Medical University, Chongqing, 400037, PR China
    Biol Blood Marrow Transplant 15:266-73. 2009
    ..In conclusion, it is a feasible approach with acceptable outcomes for patients undergoing HLA-haploidentical related HSCT by the combination of G-PBSCs and G-BM with conditioning regimens including ATG...
  50. ncbi Simultaneous deletion of MyD88 and Trif delays major histocompatibility and minor antigen mismatch allograft rejection
    Dianne McKay
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Immunol 36:1994-2002. 2006
    ..TLR) signaling influenced skin allograft rejection across a complete donor/recipient mismatch of major histocompatibility and minor antigens...
  51. ncbi Limits of HLA mismatching in unrelated hematopoietic cell transplantation
    Effie W Petersdorf
    Division of Clinical Research, D4 100 Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Blood 104:2976-80. 2004
    ..Whenever possible, HLA-C mismatches should be avoided for patients with early stage CML, and HLA-DQB1 mismatches should be avoided for patients with multiple mismatches...
  52. ncbi Allele assignment for HLA-A, -B, and -C genes to the Tenth International Histocompatibility Workshop cell lines
    V K Prasad
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, USA
    Tissue Antigens 47:538-46. 1996
    ..the allelic typing of HLA-A, -B, and -C genes for the B-lymphoblastoid reference cell lines from the Tenth International Histocompatibility Workshop. We also describe some common associations of the C alleles with HLA-A and HLA-B alleles.
  53. ncbi Posttransplantation cyclophosphamide facilitates engraftment of major histocompatibility complex-identical allogeneic marrow in mice conditioned with low-dose total body irradiation
    Leo Luznik
    Division of Immunology Hematopoiesis, Johns Hopkins Oncology Center, Baltimore, Maryland, USA
    Biol Blood Marrow Transplant 8:131-8. 2002
    ..reduced the dose of TBI required from 500 cGy to < or = 200 cGy for the engraftment of 10 million major histocompatibility complex (MHC)-identical marrow cells in 100% of recipients...
  54. ncbi A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation
    Leslie S Kean
    Division of Hematology, Oncology Blood and Marrow Transplantation, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 99:1840-9. 2002
    ..blockade (CTLA4-Ig and anti-CD40L) to produce mixed chimerism and transplantation tolerance to fully major histocompatibility complex-mismatched donor marrow...
  55. ncbi Stem cell medicine encounters the immune system
    J Andrew Bradley
    Department of Surgery, Cambridge University Clinical School, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Nat Rev Immunol 2:859-71. 2002
    ..We evaluate the probable efficacy of these approaches with a view to facilitating the use of hES cells in clinical practice...
  56. ncbi Duffy and Kidd blood group antigens: minor histocompatibility antigens involved in renal allograft rejection?
    Evelyne Lerut
    Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
    Transfusion 47:28-40. 2007
    Minor histocompatibility antigens have been poorly defined...
  57. ncbi Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease
    Eun Young Choi
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 100:4259-65. 2002
    ..Using a mouse model in which donor and recipient were incompatible at many minor histocompatibility antigens (minor H Ags), the CD8 T-cell response was tracked temporally and spatially through the course of ..
  58. ncbi Influence of one human leukocyte antigen mismatch on outcome of allogeneic bone marrow transplantation from related donors
    Wanda Hasegawa
    Bone Marrow Transplant Service, Princess Margaret Hospital University Health Network, Toronto, Ont, M5G 2M9, Canada
    Hematology 8:27-33. 2003
    ..There was an increase in mortality related to infections occurring in the setting of an increased frequency of graft failure in these patients...
  59. ncbi Rapamycin and T cell costimulatory blockade as post-transplant treatment promote fully MHC-mismatched allogeneic bone marrow engraftment under irradiation-free conditioning therapy
    T Wu
    Diabetes Institute for Immunology and Transplantation, and Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 29:949-56. 2002
    ..Rapamycin and T cell costimulatory blockade as post-transplant treatment promote bone marrow engraftment...
  60. ncbi Impact of human leucocyte antigen mismatch on graft-versus-host disease and graft failure after reduced intensity conditioning allogeneic haematopoietic stem cell transplantation from related donors
    Takanori Teshima
    Centre for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
    Br J Haematol 130:575-87. 2005
    ..RICT from a one-locus-mismatched donor may represent an effective alternative approach in patients with high-risk malignancies who lack HLA-matched related donors...
  61. ncbi Unmanipulated HLA 2-3 antigen-mismatched (haploidentical) stem cell transplantation using nonmyeloablative conditioning
    Hiroyasu Ogawa
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Biol Blood Marrow Transplant 12:1073-84. 2006
    ....
  62. doi Allogeneic stem cell transplantation from related and unrelated donors for aplastic anaemia in adults--a single-centre experience
    S Buchholz
    Zentrum Innere Medizin, Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzeltransplantation, Carl Neuberg Strasse 1, 30623, Hannover, Germany
    Ann Hematol 87:551-6. 2008
    ..Studies with greater cohorts of patients are warranted to better determine indication and timing of SCT especially from unrelated donors in AA...
  63. ncbi Comparable outcomes of matched-related and alternative donor stem cell transplantation for pediatric severe aplastic anemia
    Alana A Kennedy-Nasser
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, Texas 77030, USA
    Biol Blood Marrow Transplant 12:1277-84. 2006
    ..We conclude that, for children with SAA, AD transplantation is as effective as MSD transplantation. Further, compared with ATG, preparatory regimens containing Campath may be associated with a lower incidence of extensive, chronic GHVD...
  64. ncbi [Treatment of acquired a plastic anemia: an update]
    Seiji Kojima
    Rinsho Ketsueki 45:202-8. 2004
  65. ncbi [Current status and issues in hematopoietic stem cell transplantation]
    Mine Harada
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
    Fukuoka Igaku Zasshi 98:35-47. 2007
  66. ncbi A fludarabine-based dose-reduced conditioning regimen followed by allogeneic stem cell transplantation from related or unrelated donors in patients with myelodysplastic syndrome
    N Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Bone Marrow Transplant 28:643-7. 2001
    ....
  67. ncbi Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases: a single-center comparative analysis of genoidentical, haploidentical or unrelated donors
    S Caillat-Zucman
    Laboratory of Immunology, Hopital Necker, Paris, France
    Bone Marrow Transplant 33:1089-95. 2004
    ..The low success of HSCT using more disparate donors suggests reserving them for patients with very poor prognosis...
  68. ncbi Second allografts for relapsed hematologic malignancies: feasibility of using a different donor
    J E Duus
    Bone Marrow Transplant Program, Department of Internal Medicine, Loyola University Medical Center, Stritch School of Medicine, Maywood, IL 60153, USA
    Bone Marrow Transplant 35:261-4. 2005
    ..There were no cases of transplant-related mortality. We conclude that a second allogeneic HSCT using a different donor is a viable option for selected patients relapsing after an allograft if the original donor is not available...
  69. ncbi Reconstitution of T cell subset repertoire diversity following multiple antigen-mismatched bone marrow transplantation
    Thea M Friedman
    Biol Blood Marrow Transplant 12:1092-5. 2006
  70. ncbi Allogeneic bone marrow transplantation with non-T-cell-depleted marrow from two HLA-antigen-mismatched related donors
    Hiroyasu Ogawa
    Haematologica 89:373-5. 2004
    ..No rejection or acute GVHD >or= grade III was observed. This preliminary result is very promising...
  71. ncbi Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly human leukocyte antigen-disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishin
    William R Drobyski
    Bone Marrow Transplant Program, Froedtert Memorial Lutheran Hospital, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Blood 99:806-14. 2002
    ..There is no apparent advantage to using a mismatched unrelated versus a highly HLA-disparate family donor...
  72. ncbi Outcome of transplantation with unrelated donor bone marrow in children with severe thalassaemia
    S Hongeng
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Bone Marrow Transplant 33:377-9. 2004
    ..This study lends support to consideration of unrelated donor BMT as an acceptable therapy to cure severe thalassaemia especially in patients who are young and do not yet show irreversible severe complications of iron overload...
  73. ncbi [Recent progress in hematopoietic stem cell transplantation]
    Katsuji Shinagawa
    Division of Hematology Oncology, Okayama University Graduate School
    Gan To Kagaku Ryoho 33:727-35. 2006
    ..Further investigations of the therapy of chronic GVHD and other posttransplant problems are warranted to improve the outcome and quality of life of the patients...
  74. ncbi Successful reduced-intensity stem cell transplant from one-locus HLA-mismatched unrelated cord blood after rejection of unrelated bone marrow in an infant with myelogenous leukemia
    Atsushi Shibuya
    Department of Pediatrics, Saitama Medical School, Iruma gun Saitama, Japan
    Hematology 7:101-3. 2002
    ..In this case, it seems that remission was induced by an adequate graft-versus-leukemia effect and mild chronic graft-versus-disease due to the HLA-A difference more than DRB1 matched between the patient and the cord blood stem cells...
  75. ncbi Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce dura
    Dietger Niederwieser
    Division of Hematology and Oncology, University of Leipzig, Germany
    Blood 101:1620-9. 2003
    ..HCT from HLA-matched or mismatched unrelated donors can be performed with a reduced intensity conditioning regimen in patients ineligible for conventional HCT...
  76. ncbi Which donor should be chosen for hematopoietic stem cell transplantation among unrelated HLA-A, -B, and -DRB1 genomically identical volunteers?
    Olle Ringden
    Centre for Allogeneic Stem Cell Transplantation, Division of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Biol Blood Marrow Transplant 10:128-34. 2004
    ..The 5-year survival was 72%, 48%, and 30% with 0, 1, and 2 risk factors, respectively. We concluded that unrelated hematopoietic stem cell transplantation may be improved if an optimal donor and immunosuppression are chosen...
  77. ncbi Allogeneic hemopoietic stem cell transplantation (HSCT) for Wiskott-Aldrich syndrome: a report of the Spanish Working Party for Blood and Marrow Transplantation in Children (GETMON)
    A Munoz
    Department of Pediatrics, Hospital Ramon y Cajal University of Alcala, Madrid, Spain
    Pediatr Hematol Oncol 24:393-402. 2007
    ..Allogeneic hemopoietic stem cell transplantation must be utilized in all patients with severe Wisckott-Aldrich syndrome, using the most suitable graft variant for each patient...
  78. ncbi [Allogeneic hematopoietic stem cell transplantation for solid tumors]
    Yoshinobu Kanda
    Rinsho Ketsueki 45:189-94. 2004
  79. ncbi [Treatment outcome of hematopoietic stem cell transplantation for aplastic anemia]
    Shinichiro Okamoto
    Nihon Naika Gakkai Zasshi 94:1309-15. 2005
  80. ncbi Value of chemotherapy before allogeneic hematopoietic stem cell transplantation from an HLA-identical sibling donor for myelodysplastic syndrome
    K Nakai
    First Department of Internal Medicine, Kansai Medical University, Japan
    Leukemia 19:396-401. 2005
    ..44). Although only a randomized controlled trial will be able to establish a definite conclusion, these results do not support the administration of induction chemotherapy for patients with RAEB-t or secondary AML before allo-SCT...
  81. ncbi Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors
    Sebastian Giebel
    Department of Haematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland
    Blood 102:814-9. 2003
    ..These data indicate that natural killer (NK) cell alloreactivity is associated with better outcome after URD-HSC transplantation when ATG is used as part of GVHD prophylaxis...
  82. ncbi [Successful second transplant from one-locus HLA-mismatched unrelated donor for graft rejection following initial transplant from another unrelated donor in a patient with chronic myelogenous leukemia]
    M Tanaka
    First Department of Internal Medicine, Yokohama City University School of Medicine
    Rinsho Ketsueki 42:656-8. 2001
    ..Engraftment was obtained on day 27, and no graft failure was occurred at the time of writing. This case suggests that strong immunosuppression may have prevented rejection of the second bone marrow graft...
  83. ncbi Feasibility and results of bone marrow transplantation from an HLA-mismatched unrelated donor for children and young adults with acquired severe aplastic anemia
    Hiroshi Yagasaki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 85:437-42. 2007
    ..All patients are alive at 9 to 56 months after transplantation (median, 33 months). Considering our encouraging results, HLA-mismatched unrelated-donor BMT for SAA is feasible as a salvage therapy for nonresponders to IST...
  84. ncbi Cyclosporine A and mycophenolate mofetil vs cyclosporine A and methotrexate for graft-versus-host disease prophylaxis after stem cell transplantation from HLA-identical siblings
    F Neumann
    Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Duesseldorf, Germany, Moorenstrasse 5, Duesseldorf, Germany
    Bone Marrow Transplant 35:1089-93. 2005
    ..We conclude that the combination of CSA/MMF appears equivalent to CSA/MTX for GVHD prophylaxis in patients receiving conventional-intensity SCT from HLA-identical siblings...
  85. doi Hematopoietic stem cell transplantation: 40 years of continuous progress and evolution
    Fulvio Porta
    Haematologica 93:1607-10. 2008
  86. ncbi [Hematopoietic stem cell transplantation: is it an immunologic therapy?]
    Alberto Olaya Vargas
    Programa de Progenitores Hematopoyéticos, Instituto Nacional de Pediatria, Av Insurgentes Sur 3700 C, Col Insurgentes Cuicuilco, CP 04530, Mexico, DF
    Rev Alerg Mex 50:192-7. 2003
    ..Recent advances in our understanding of the immunobiology of stem-cell engraftment, tolerance and tumor eradication are allowing clinicians to better harness this powerful effect...
  87. ncbi Rapid hematopoietic engraftment following fractionated TBI conditioning and transplantation with CD34(+) enriched hematopoietic progenitor cells from partially mismatched related donors
    I Redei
    Emory University School of Medicine, Winship Cancer Institute, Department of Hematology and Oncology, Bone Marrow and Stem Cell Transplant Center, Emory University, Atlanta, GA, USA
    Bone Marrow Transplant 30:335-40. 2002
    ..Combination of stringent ex vivo TCD and pre-transplant ATG is effective GVHD prophylaxis...
  88. doi Comparison of two doses of antithymocyte globulin in patients undergoing matched unrelated donor allogeneic stem cell transplantation
    Francis Ayuk
    Department of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany
    Biol Blood Marrow Transplant 14:913-9. 2008
    ..A prospective randomized study comparing these 2 doses of ATG-F is warranted...
  89. ncbi Successful application of nonmyeloablative transplantation for paroxysmal nocturnal hemoglobinuria
    K Suenaga
    Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan
    Exp Hematol 29:639-42. 2001
    ..CONCLUSIONS: NST may become a safe and curative approach in patients with PNH. Further studies are needed to establish the role of NST for treatment of PNH...
  90. ncbi Allogeneic hematopoietic cell transplantation for paroxysmal nocturnal hemoglobinuria
    Jae Lyun Lee
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Eur J Haematol 71:114-8. 2003
    ..Although allogeneic hematopoietic cell transplantation (HCT) has a potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), appropriate indication and conditioning regimen for HCT have not been established...
  91. ncbi Effects of extending the duration of postgrafting immunosuppression and substituting granulocyte-colony-stimulating factor-mobilized peripheral blood mononuclear cells for marrow in allogeneic engraftment in a nonmyeloablative canine transplantation model
    J M Zaucha
    Clinical Research Division, Fred Hutchinson Cancer Research Center Washington, Seattle 98109-1024, USA
    Biol Blood Marrow Transplant 7:513-6. 2001
    ..11). However, increasing the duration of posttransplantation immunosuppression with CSP from 35 to 100 days favorably influenced stable donor engraftment (P = .06)...
  92. ncbi Allogeneic bone marrow transplantation from partially mismatched related donors as therapy for primary induction failure acute myeloid leukemia
    K Y Chiang
    Division of Transplantation Medicine, South Carolina Cancer Center, Palmetto Richland Memorial Hospital, Columbia, SC 29203, USA
    Bone Marrow Transplant 27:507-10. 2001
    ..54 and 0.19, respectively. We concluded that a PMRD graft is a viable option, comparable to the use of matched related or unrelated donors, in patients with PIF AML in whom time is of the essence...
  93. doi Recovery from established graft-vs-host disease achieved by bone marrow transplantation from a third-party allogeneic donor
    Yuki Taniguchi
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Exp Hematol 36:1216-25. 2008
    ..We investigated whether established graft-vs-host disease (GVHD) could be successfully treated by a second allogeneic bone marrow transplantation (BMT) through elimination of first donor-derived lymphocytes responsible for GVHD...
  94. ncbi Recent advances in allogeneic hematopoietic stem-cell transplantation
    Steven M Devine
    Division of Oncology, Section of Bone Marrow Transplantation and Leukemia, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine
    J Lab Clin Med 141:7-32. 2003
  95. ncbi Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling
    Jon J van Rood
    Leiden University Medical Center, The Netherlands
    Blood 99:1572-7. 2002
    ....
  96. ncbi Impact of CD31 mismatches on the outcome of hematopoeitic stem cell transplant of HLA-identical sibling
    Farha A el-Chennawi
    Clinical Immunology Unit, Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura, Egypt
    Hematology 11:227-34. 2006
    ..allogeneic hematopoeitic stem cell transplantation (HSCT) is often attributed to mismatching of minor histocompatibility antigens (mHags), which are poorly defined in humans...
  97. ncbi Allogeneic bone marrow transplantation for chronic myelogenous leukemia: comparative analysis of unrelated versus matched sibling donor transplantation
    Daniel J Weisdorf
    University of Minnesota Mayo Mail Code 480, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 99:1971-7. 2002
    ..63% of URDs were matched at HLA-A, -B, and at -DRB1 alleles; all MSDs were genotypically identical at major histocompatibility loci. URD recipients were younger (median 36 vs 39, P =...
  98. ncbi [Present status in hematopoietic stem cell transplantation (discussion)]
    Shunichi Kato
    Nihon Naika Gakkai Zasshi 94:1369-86. 2005
  99. pmc HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide
    Leo Luznik
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Biol Blood Marrow Transplant 14:641-50. 2008
    ..02). Nonmyeloablative HLA-haploidentical BMT with posttransplantation Cy is associated with acceptable rates of fatal graft failure and severe aGVHD or cGVHD...
  100. ncbi [Present status and future prospects in reduced intensity stem cell transplantation]
    Yoichi Takaue
    Nihon Naika Gakkai Zasshi 94:1421-7. 2005
  101. ncbi [Treatment outcome of hematopoietic stem cell transplantation for myelodysplastic syndrome]
    Arinobu Tojyo
    Nihon Naika Gakkai Zasshi 94:1316-21. 2005

Research Grants73

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Tibor T Glant; Fiscal Year: 2016
    ..The major genetic contributor is the major histocompatibility complex (MHC)-encoded (human leukocyte antigen) HLA-B27 first described in 1973...
  3. Tibor T Glant; Fiscal Year: 2014
    ..development and severity, and recessive inheritance of disease susceptibility, dictated by both the major histocompatibility complex (MHC)- and non-MHC-associated genes are additional characteristics that make this model an ideal ..
  4. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..of allogeneic stem cell transplantation (allo-SCT) mediated by donor T cells that recognize minor and major histocompatibility complex (MHC) differences in the host...
  5. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..Specific Aim 2: to evaluate and validate a putative b2-M receptor, a non-classical major histocompatibility complex (MHC)-like molecule, the hereditary hemochromatosis associated gene, HFE...
  6. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2013
    ..sex-specific neuroendocrine responses, permit the discrimination of scents based on differences in major histocompatibility alleles, and sex-dependently activate regions of the hypothalamus involved in reproduction...
  7. Jakub Tolar; Fiscal Year: 2016
    ..In this application, we are proposing to use novel models to address the remaining issues of histocompatibility, tumorigenicity, and genetic stability of iPSC-derived cells We have also designed a ZFN-mediated strategy ..
  8. Matthew B Grisham; Fiscal Year: 2015
    ..immunosuppressive activity of MSCs in different mouse models of autoimmunity is not restricted to the major histocompatibility complex suggesting that MSCs are "immune-privileged"...
  9. Irritable bowel syndrome-diarrhea: the role of gluten intolerance and HLA-DQ2
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..The genotype of interest is the mixed histocompatibility complex, HLA...
  10. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
    ..Using the tight- skin mouse that spontaneously develops skin fibrosis;a minor histocompatibility model of GVHD that also results in skin fibrosis as well as fibrosis of internal organs;and bleomycin ..
  11. Laurence J N Cooper; Fiscal Year: 2014
    ..specificity of T cells to the B-cell lineage-restricted cell-surface molecule CD19 independent of major histocompatibility complex (MHC)...
  12. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..1) placental trophoblast cells of SCNT fetuses, in contrast to control fetuses, express classical major histocompatibility complex class I (MHC-I) antigens early in pregnancy, (2) T lymphocytes accumulate in the uterine stroma of ..
  13. Jay Reddy; Fiscal Year: 2016
    ..Using major histocompatibility complex (MHC) class II dextramers for cardiac myosin heavy chain (Myhc)-[unreadable] 334-352, the team has ..
  14. ROCK inhibitor suppression of GVHD with retention of GVL response
    Sujatha Iyengar; Fiscal Year: 2012
    ..Three small molecule ROCK inhibitors will be tested in MHC and minor histocompatibility antigen (miHA) disparate BMT mouse models...
  15. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012
    ..antigens from phagocytosed bacteria - such as Listeria monocytogenes - are processed and presented by major histocompatibility complex (MHC) class I (MHC-I) and class II (MHC-II) molecules to activate naove pathogen-specific CD8+ and ..
  16. Identification of Inhibitors that Stabilize ER Degradation Substrates
    Domenico Tortorella; Fiscal Year: 2012
    ..and US11 gene products have co-opted ERAD to mediate the destruction of the immunological protein major histocompatibility complex (MHC) class I heavy chain to limit viral clearance by cytotoxic T cells...
  17. Kristin A Hogquist; Fiscal Year: 2016
    ..despite the production of CD4+ T cells expressing T cell receptors (TCR) specific for self peptide (p):major histocompatibility complex II (MHCII) ligands...
  18. Hunting for Endogenous Ligands for Invariant Natural Killer T Cells
    Peng George Wang; Fiscal Year: 2010
    ..Conventional CD4+ and CD8+ T cells of the immune system recognize specific peptide antigens bound to major histocompatibility complex (MHC) class II or MHC class I molecules, respectively...
  19. Gad Shaulsky; Fiscal Year: 2015
    ..In mammals, allorecognition is mediated by the Major Histocompatibility Complex (MHC), which is part of the immune system...
  20. Irving L Weissman; Fiscal Year: 2016
    ..We will study the role of the innate histocompatibility system in allogeneic HCT in protochordates mice and humans...
  21. Study of the HFE Transferrin Receptor interaction in mammalian iron homeostasis
    Paul Schmidt; Fiscal Year: 2010
    ..HFE is a major histocompatibility complex (MHC) class l-like gene that forms a protein-protein complex with TFR soon after synthesis and is ..
  22. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..by highly polymorphic interactions between killer cell immunoglobulin-like receptors (KIR) and major histocompatibility complex (MHC) I ligands...
  23. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..During the last funding period we developed a sensitive new technique to detect polyclonal peptide-major histocompatibility complex class II molecule (pMHCII)-specific CD4+ T cells and used it to track CD4+ T cells expressing ..
  24. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael J Bevan; Fiscal Year: 2012
    ..Vaccination against infectious disease is the most cost-effective strategy in promoting human health. Our research is aimed at discovering the conditions that make long-term protection possible following vaccine delivery. ..
  25. MAX DALE COOPER; Fiscal Year: 2016
    ..A long term goal is to identify the lamprey histocompatibility antigens to test the hypothesis that VLRA and VLRC recognize these to achieve self versus non-self ..
  26. Genome-wide Identification of Minor Histocompatibility Antigens
    Shoudan Liang; Fiscal Year: 2012
    ..GVL is mediated by cytotoxic T lymphocytes (CTLs) that recognize the minor histocompatibility antigens (mHAs) derived from the genetic differences in the donor and recipient, particularly single ..
  27. Leslie S Kean; Fiscal Year: 2016
    ..aGVHD arises due to the activation and proliferation of engrafting donor T cells, triggered by histocompatibility disparities between donor and recipient...
  28. Transfusion Induced BMT Rejection
    James C Zimring; Fiscal Year: 2013
    ..Since BMT in this setting is MHC matched, these antigens would be minor histocompatibility antigens (mHAs)...
  29. EMBRYONIC STEM CELLS INDUCE SPECIFIC GRAFT TOLERANCE
    Nicholas Zavazava; Fiscal Year: 2012
    ..to form hematopoietic precursor cells (HPCs) that can safely be used to induce mixed chimerism across major histocompatibility barriers with minimal requirement for immunosuppression...
  30. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    REBECCA CYNTHIA OBENG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Major histocompatibility complex (MHC) class I molecules display peptides derived from endogenous proteins that have been degraded within the cell...
  31. Development & Characterization of Tyrosinase Epitope Specific TCR Transgenic Mice
    Shikhar Mehrotra; Fiscal Year: 2010
    ..that are widely expressed by cells of the melanocyte lineage and naturally presented by class I major histocompatibility complex molecules provide targets for vaccination-induced, cytotoxic T lymphocyte (CTL)-based immunotherapy ..
  32. Stat5b in Lymphomagenesis: Mechanistic and Therapeutic Implications
    John A Kelly; Fiscal Year: 2012
    ..we investigated the mechanism of Stat5-mediated lymphomagenesis by exploring the contributions of major histocompatibility complex (MHC)/T-cell receptor (TCR) and pre-TCR signals...
  33. Complete genomic DNA sequence of the sooty mangabey MHC
    Daniel E Geraghty; Fiscal Year: 2012
    ..out the following specific aims: (1) To derive complete and high quality genomic sequences of the major histocompatibility complex (MHC) and killer Ig-like receptor (KIR) regions from the sooty mangabey...
  34. Mapping the functional major histocompatibility complex genes in zebrafish
    JILL L DE JONG; Fiscal Year: 2012
    ..methods have been lagging in the zebrafish due to lack of knowledge about the zebrafish Major Histocompatibility Complex (MHC) genes...
  35. Down-regulation of MHC class l molecules by HCMV US2
    Domenico Tortorella; Fiscal Year: 2009
    ..and US11 interfere with CTL recognition of HCMV-infected cells by preventing the surface expression of major histocompatibility complex (MHC) class I molecules...
  36. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
    CD74 is a cell surface receptor, but is better known as the human histocompatibility leukocyte antigen (HLA) class ll-assoociated invariant chain that transports class II from the endoplasmic reticulum to vesicles which fuse with ..
  37. T Cell Modulation by NKG2D
    Thomas Spies; Fiscal Year: 2013
    ..Ligands of NKG2D in humans include the major histocompatibility complex class I-related chain A (MICA), which is frequently expressed in epithelial tumors and certain ..
  38. JOHN ANDREW HANSEN; Fiscal Year: 2014
    ..to test for association with GVHD, relapse and mortality, and ii) identifying non-MHC loci encoding minor histocompatibility antigens that serve as the targets for GVHD and the graft-vs-leukemia (GVL) effect...
  39. Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral
    Ann F Cheung; Fiscal Year: 2010
    ..Utilizing a proteomics approach, major histocompatibility complex (MHC) class I- presented peptides will be extracted and sequenced from HLA-A2+ ovarian cancer cell ..
  40. Donor Stem Cells, Campath, T/B Cell Regulation In HLA-Identical Renal Transplants
    Joshua Miller; Fiscal Year: 2010
    ..The polymorphisms encode minor histocompatibility antigens (mHAgs), and also what we designate herein as "new immune response genes" ('nIR'genes)...
  41. DOUGLAS FREDERICK LEVINSON; Fiscal Year: 2015
    ..The strongest common- SNP signal spans the Major Histocompatibility Complex (MHC, chromosome 6p21) which includes the human leukocyte antigen (HLA) loci...
  42. From destructive to protective: altering the fate of a diabetogenic T cell using
    JENNIFER DIANNA HOOD; Fiscal Year: 2012
    ..amino acids that contact the T cell receptor, we propose that by changing amino acids that contact the major histocompatibility complex (MHC) we can alter T cell fate without the disadvantages of APLs...
  43. Marco Colonna; Fiscal Year: 2014
    ..2) development of endodermal lineages including (-cells, 3) processing &presentation of antigens by histocompatibility molecules in Type 1 diabetes, 4) immune tolerance &autoimmunity in Type 1 diabetes, 5) KATP channels &..
  44. Maturation of Human Lymphocytes for Transplantation
    Gerald J Spangrude; Fiscal Year: 2010
    ..One of the major obstacles facing tissue transplantation is the issue of histocompatibility between donor and recipient...
  45. Malini Raghavan; Fiscal Year: 2016
    Assembly of major histocompatibility complex (MHC) class I molecules occurs within the endoplasmic reticulum (ER) of cells...
  46. DAIVA MARIA MATTIS; Fiscal Year: 2014
    ..provided by applicant): T cell receptors recognize peptide antigens bound to and presented by the major histocompatibility complex (MHC) in a highly specific manner...
  47. Mechanisms of Acceptance in Mouse Renal Allografts
    Robert B Colvin; Fiscal Year: 2013
    ..We will test for strain differences in DC function, cytokine/chemokine/complement mediators, minor histocompatibility antigens and ability to generate Foxp3 cells...
  48. PETER R PARHAM; Fiscal Year: 2016
    ..in immunity and reproduction are variable receptors that recognize polymorphic determinants of major histocompatibility complex (MHC) class I molecules...
  49. Joyce C Solheim; Fiscal Year: 2014
    ..by this cancer are poorly understood, although there have been reports of down-regulated expression of major histocompatibility complex (MHC) class I molecules, and correlation of decreased MHC class I expression and poor survival...
  50. Function of a novel subset of dendritic cells in EAE
    Estelle Bettelli; Fiscal Year: 2013
    ..The interactions between CD4+ T cells and major histocompatibility class II (MHCII)+ antigen presenting cells (APCs) are necessary in both the periphery and central nervous ..
  51. JAMES TILFORD ELDER; Fiscal Year: 2016
    ..We have mapped PSORS1, the major psoriasis susceptibility gene in the major histocompatibility complex (MHC), to within or very near HLA-Cw6 by DNA sequencing and recombinant ancestral haplotype mapping...
  52. The Immunogenetics of Macaques Used in Biodefense Research
    ALESSANDRO D SETTE; Fiscal Year: 2011
    ..Our strategy relies on the identification of common major histocompatibility (MHC) class I alleles, determining their peptide binding motifs, developing bioinformatic tools to predict ..
  53. Oliver W Press; Fiscal Year: 2015
    ..TBI) and allogeneic HCT in patients with AML in remission (Aim 1), extend the approach to patients lacking histocompatibility locus antigen (HLA)-matched donors by investigating 131l-BCS in the setting of haplo-identical ..
  54. Peter Cresswell; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Major Histocompatibility Complex (MHC) class I glycoproteins, the products of HLA-A, B and C genes in humans, are critical for T cell mediated immune responses to viruses and intracellular pathogens...
  55. Richard S Blumberg; Fiscal Year: 2014
    CDId is a major histocompatibility complex (MHC) class 1-related molecule that is expressed by intestinal epithelial cells (lEC), hepatocytes and professional antigen presenting cejls (APCs) including dendritic cells (DC), monocytes and B ..
  56. Luc Teyton; Fiscal Year: 2015
    ..for both conditions, we have decided to study the mechanisms underlying their association to the same Major Histocompatibility Complex (MHC) class II molecules, HLA-DQ8...
  57. Carla J Shatz; Fiscal Year: 2016
    ..experience-dependent synaptic plasticity in visual cortex? In the immune system PirB is a receptor for Major Histocompatibility Class I molecules, famous ligands for T-cell receptors...
  58. Carole Ober; Fiscal Year: 2016
    ..underlie chronic airway inflammation with a clear focus on one immune tolerance molecule, the class I major histocompatibility complex protein human leukocyte antigen (HLA)-G, that we believe has an important role in modulating airway ..
  59. Drug Delivery to CNS Endothelial Cells by Targeting Peptide-MHC Complexes
    Ulrich Bickel; Fiscal Year: 2009
    ..The objective of this particular application is to establish specific peptide- major histocompatibility (MHC) class I complexes on brain vascular endothelium as viable portals for drug delivery...
  60. Bioengineered siRNA/Nanoparticles to Prevent Human Transplant Rejection
    George Tellides; Fiscal Year: 2013
    ..rodents, have circulating effector memory T cells capable of directly recognizing non-self-major histocompatibility complex (MHC) molecules and, upon activation, causing graft rejection...
  61. OLGA AFANASIEV; Fiscal Year: 2014
    ..The mechanisms and reversibility of Major Histocompatibility Complex class I (MHC-I) down-regulation will be explored in Aim 3...
  62. Warren D Shlomchik; Fiscal Year: 2016
    ..In MHC-matched alloSCT, GVL-inducing T cells target minor histocompatibility antigens (miHAs)...
  63. Cytokine Induced CD26 Modulation of Adult Hematopoietic Stem Cell Trafficking
    Kent Christopherson; Fiscal Year: 2009
    ..Given that CB is readily available, has a lower histocompatibility requirement, and carries a reduced risk of graft vs...
  64. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the applicant's abstract) - The major histocompatibility complex (MHC) is an important susceptibility locus for many human autoimmune diseases...
  65. NKT Cells Immunotherapy: Targeting Dendritic Cells with Glycolipid Liposomes
    Peng Wang; Fiscal Year: 2007
    ..Conventional CD4+ and CD8+ T cells of the immune system recognize specific peptide antigens bound to major histocompatibility complex (MHC) class II or MHC class I molecules, respectively...
  66. Replication of Association Signals Identified in Ulcerative Colitis GWAS
    Richard H Duerr; Fiscal Year: 2010
    ..Variants in IL23R and the major histocompatibility complex are associated with both ulcerative colitis and Crohn's disease, but most of the identified ..
  67. GM-CSF secreting tumor cell vaccines to enhance post-transplant anti-CLL immunity
    Catherine Wu; Fiscal Year: 2009
    ..in CLL and that mostly had perfect sequence identity between host and donor (and hence are not minor histocompatibility antigens)...
  68. HOST GENETIC DETERMINANTS OF HIV PATHOGENESIS
    Sunil Ahuja; Fiscal Year: 1999
    ..the genes encoding critical HIV entry cofactors (chemokine receptors) and their ligands, as well the major histocompatibility (MHC) proteins strongly influence HIV-1 transmission and AIDS pathogenesis...
  69. REGULATION OF MHC GENES IN TROPHOBLAST
    DOUGLAS ANTCZAK; Fiscal Year: 1999
    ..mechanism that ensures maternal tolerance of the fetal allograft is the regulation of expression of Major Histocompatibility Complex (MHC) class I and class II antigens on the trophoblast cells that comprise the physical barrier ..
  70. LMP POLYMORPHISMS IN B27-ASSOCIATED JUVENILE ARTHRITIS
    Robert Colbert; Fiscal Year: 2001
    ..One genetic factor encoded in the class I region of the major histocompatibility complex (MHC), and associated with late onset particular JRA, is HLA-B27...
  71. Mixed Chimerism in Haploidentical Non-human Primates
    Bernhard Hering; Fiscal Year: 2006
    ..this project is to improve the safety and efficacy of mixed hematopoietic chimerism protocols across major histocompatibility (MHC) barriers such that this approach can be more widely applied for the induction of robust graft ..