transplantation immunology

Summary

Summary: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.

Top Publications

  1. ncbi Efficacy and safety of inhaled tacrolimus in rat lung transplantation
    Noboru Ide
    Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Thorac Cardiovasc Surg 133:548-53. 2007
  2. pmc HLA-mismatched renal transplantation without maintenance immunosuppression
    Tatsuo Kawai
    Transplantation Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 358:353-61. 2008
  3. ncbi Tolerance versus immune response -- microRNAs as important elements in the regulation of the HLA-G gene expression
    T D Veit
    Genetics Department, Post Graduation Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Transpl Immunol 20:229-31. 2009
  4. ncbi A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression
    C P Larsen
    Emory Transplant Center, Department of Surgery, School of Medicine, Emory University Atlanta, GA, USA
    Am J Transplant 6:876-83. 2006
  5. ncbi Dendritic cells: tools and targets for transplant tolerance
    S M Barratt-Boyes
    Department of Infectious Diseases and Microbiology, University of Pittsburgh, PA, USA
    Am J Transplant 5:2807-13. 2005
  6. ncbi Soluble HLA-G expression and renal graft acceptance
    J Qiu
    Terasaki Foundation Laboratory, Los Angeles, California, USA
    Am J Transplant 6:2152-6. 2006
  7. ncbi Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    B Salomon
    The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 19:225-52. 2001
  8. pmc Tolerance: of mice and men
    David H Sachs
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Clin Invest 111:1819-21. 2003
  9. ncbi Lack of donor hyporesponsiveness and donor chimerism after clinical transplantation of the hand
    Darla K Granger
    Department of Surgery, University of Louisville, Louisville, KY, USA
    Transplantation 74:1624-30. 2002
  10. ncbi Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management
    Richard Kowalski
    Cylex Incorporated 8980 I, Columbia, MD 21045, USA
    Clin Transplant 17:77-88. 2003

Research Grants

  1. RESEARCH TRAINING IN RESPIRATORY BIOLOGY
    Anne I Sperling; Fiscal Year: 2013
  2. VIRAL INFECTION INFLUENCE ON TRANSPLANTATION TOLERANCE
    DALE LESLIE GREINER; Fiscal Year: 2013
  3. MicroRNA regulation of human T and B cell activation
    Daniel R Salomon; Fiscal Year: 2013
  4. Vascular Endothelium Directs the Development of Regulatory T Cells
    Daniel Kreisel; Fiscal Year: 2010
  5. Training Grant in Academic Nephrology
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2013
  6. TRAINING IN TRANSPLANTATION BIOLOGY
    David H Sachs; Fiscal Year: 2012
  7. CAREER DEVELOPMENT IN PEDIATRIC AND MEDICAL ONCOLOGY
    Irwin D Bernstein; Fiscal Year: 2013
  8. Montagna Symposium on the Biology of Skin
    Molly F Kulesz-Martin; Fiscal Year: 2013
  9. Lymphocyte Activation and Gene Expression
    Andrew D Robertson; Fiscal Year: 2010
  10. IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGY
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2013

Detail Information

Publications251 found, 100 shown here

  1. ncbi Efficacy and safety of inhaled tacrolimus in rat lung transplantation
    Noboru Ide
    Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Thorac Cardiovasc Surg 133:548-53. 2007
    ..The aim of this study was to investigate the efficacy and safety of inhaled tacrolimus for preventing acute rejection of rat lung allografts...
  2. pmc HLA-mismatched renal transplantation without maintenance immunosuppression
    Tatsuo Kawai
    Transplantation Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 358:353-61. 2008
    ....
  3. ncbi Tolerance versus immune response -- microRNAs as important elements in the regulation of the HLA-G gene expression
    T D Veit
    Genetics Department, Post Graduation Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Transpl Immunol 20:229-31. 2009
    ....
  4. ncbi A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression
    C P Larsen
    Emory Transplant Center, Department of Surgery, School of Medicine, Emory University Atlanta, GA, USA
    Am J Transplant 6:876-83. 2006
    ..Recent clinical data using the selective costimulation blocker, belatacept (LEA29Y), as a part of a CNI-free maintenance immunosuppressive regimen in renal transplantation is highlighted...
  5. ncbi Dendritic cells: tools and targets for transplant tolerance
    S M Barratt-Boyes
    Department of Infectious Diseases and Microbiology, University of Pittsburgh, PA, USA
    Am J Transplant 5:2807-13. 2005
    ..This minireview highlights recent developments in the field that are leading to new avenues for exploiting DC in the promotion of transplant tolerance...
  6. ncbi Soluble HLA-G expression and renal graft acceptance
    J Qiu
    Terasaki Foundation Laboratory, Los Angeles, California, USA
    Am J Transplant 6:2152-6. 2006
    ..sHLA-G had a negative association with allograft failure from chronic rejection, and a negative relationship with the production of HLA IgG antibodies. The significance of sHLA-G in renal transplants remains to be determined...
  7. ncbi Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    B Salomon
    The Committee on Immunology, Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 19:225-52. 2001
    ..The implications of these complexities and the potential for use of these therapies in clinical immune intervention are discussed...
  8. pmc Tolerance: of mice and men
    David H Sachs
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Clin Invest 111:1819-21. 2003
    ..An important study now reveals that individuals harboring virally-induced memory T cells that are cross reactive with donor alloantigen are resistant to conventional strategies designed to induce transplant tolerance...
  9. ncbi Lack of donor hyporesponsiveness and donor chimerism after clinical transplantation of the hand
    Darla K Granger
    Department of Surgery, University of Louisville, Louisville, KY, USA
    Transplantation 74:1624-30. 2002
    ..We have followed two hand transplant recipients for more than 1 year to determine the level of chimerism and possible donor-specific tolerance, in addition to possible GVHD...
  10. ncbi Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management
    Richard Kowalski
    Cylex Incorporated 8980 I, Columbia, MD 21045, USA
    Clin Transplant 17:77-88. 2003
    ..This cross-sectional study was designed to establish ranges for reactivity of this bioassay in the assessment of functional immunity for an individual solid organ recipient at any point in time...
  11. ncbi Tolerance and chimerism after renal and hematopoietic-cell transplantation
    John D Scandling
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    N Engl J Med 358:362-8. 2008
    ..Adverse events requiring hospitalization were limited to a 2-day episode of fever with neutropenia. The patient has had neither rejection episodes nor clinical manifestations of graft-versus-host disease...
  12. ncbi Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation
    Katarina Le Blanc
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Biol Blood Marrow Transplant 11:321-34. 2005
    ..They are also of potential use in the treatment of organ transplant rejection and in autoimmune inflammatory bowel disorders where immunomodulation and tissue repair are needed...
  13. pmc Inhibitory KIR-HLA receptor-ligand mismatch in autologous haematopoietic stem cell transplantation for solid tumour and lymphoma
    W Leung
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Br J Cancer 97:539-42. 2007
    ..01). The potential applicability of the receptor-ligand mismatch model to autologous HCTs and to patients with lymphoma or solid tumour is clinically significant because of the prevalence of the HCT procedure...
  14. pmc Transplantation immunology: solid organ and bone marrow
    Javier Chinen
    Department of Pediatrics, Allergy Immunology, Baylor College of Medicine, Houston, USA
    J Allergy Clin Immunol 125:S324-35. 2010
    ....
  15. ncbi Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it
    David C Neujahr
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 176:4632-9. 2006
    ..These data have clinically relevant implications related to the development of novel strategies to overcome resistance to tolerance...
  16. ncbi Absence of innate MyD88 signaling promotes inducible allograft acceptance
    Wendy E Walker
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 177:5307-16. 2006
    ..Therefore, this study provides evidence that absence of MyD88 promotes inducible allograft acceptance and implies that inhibiting innate immunity may be a potential, clinically relevant strategy to facilitate transplantation tolerance...
  17. pmc Chimerism and tolerance in transplantation
    Thomas E Starzl
    Transplantation Institute, University of Pittsburgh Medical Center, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 101:14607-14. 2004
    ..The insight was then applied to improve the timing and dosage of immunosuppression of current human transplant recipients...
  18. ncbi HLA-G molecules: from maternal-fetal tolerance to tissue acceptance
    Edgardo D Carosella
    Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, CEA Commissariat à l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    Adv Immunol 81:199-252. 2003
    ..We review these points, with special emphasis on the role of HLA-G in human pathologies, such as cancer, viral infection, and inflammatory diseases, as well as in organ transplantation...
  19. ncbi Tolerance to limb tissue allografts between swine matched for major histocompatibility complex antigens
    W P Lee
    Plastic Surgery Research Laboratory and Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Plast Reconstr Surg 107:1482-90; discussion 1491-2. 2001
    ..Demonstration of limb tissue allograft survival in a large animal model without long-term immunosuppression represents an important step toward clinical transplantation...
  20. ncbi Composite tissue allograft extends a helping hand to transplant immunologists
    O Thaunat
    Institut National de la Santé et de la Recherche Médicale U681, Institut Biomedical des Cordeliers, Universite Pierre et Marie Curie Paris VI, Paris, France
    Am J Transplant 6:2238-42. 2006
    ..In this sense, composite tissue allografts extend a helping hand to transplant immunologists...
  21. ncbi Memory T-cell predominance following T-cell depletional therapy derives from homeostatic expansion of naive T cells
    A Sener
    Division of Transplantation, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Transplant 9:2615-23. 2009
    ....
  22. pmc Composite tissue transplantation: a rapidly advancing field
    K V Ravindra
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    Transplant Proc 40:1237-48. 2008
    ..Additionally, some important hurdles that must be overcome in using bone marrow chimerism to induce tolerance to CTA are also discussed...
  23. ncbi Transplantation immunology and the central nervous system
    Anat R Tambur
    Department of Neurosurgery, University of Illinois at Chicago, Chicago 60612, USA
    Neurol Res 26:243-55. 2004
    ..This, in turn, should have significant importance in the choice of anti-rejection drugs to be used...
  24. ncbi Induction of transplant tolerance with immunodominant allopeptide-pulsed host lymphoid and myeloid dendritic cells
    M Garrovillo
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Am J Transplant 1:129-37. 2001
    ..This study suggests that intravenous administration of genetically engineered dendritic cells expressing donor MHC molecules has the potential of inducing transplant tolerance...
  25. ncbi The role of toll-like receptors in solid organ transplantation
    Jagdeep Obhrai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Transplantation 81:497-502. 2006
    ..Further investigation of how innate immunity impacts solid organ transplantation will likely lead to improved therapeutics for transplant recipients...
  26. ncbi Costimulation blockade and its possible future use in clinical transplantation
    Renaud Snanoudj
    Service de Nephrologie et Transplantation Renale, Hôpital du Kremlin Bicêtre, Le Kremlin Bicetre, INSERM U542, Villejuif, France
    Transpl Int 19:693-704. 2006
    ..Given the diversity of the different costimulation molecules, future strategies for human transplantation may involve the simultaneous blockade of several selected pathways or the simultaneous use of conventional immunosuppressants...
  27. ncbi The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning
    E Simpson
    Medical Research Council Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Annu Rev Immunol 15:39-61. 1997
    ..Each of the Hya genes in mice is ubiquitously expressed but of unknown function. Their X chromosome homologues do not undergo X inactivation...
  28. pmc Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs)
    Barbara Savoldo
    Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, 6621 Fannin St, MC 3 3320, Houston, TX 77030, USA
    Blood 108:2942-9. 2006
    ..These data are consistent with an expansion and persistence of adoptively transferred EBV-CTLs that is limited in the presence of continued immunosuppression but that nonetheless produces clinically useful antiviral activity...
  29. ncbi Age and immune response in organ transplantation
    Paulo N A Martins
    Department of General and Transplantation Surgery, Charite Virchow Clinic, Humboldt University, Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Transplantation 79:127-32. 2005
    ..Here, we are going to review the immunologic changes associated with the aging process relevant for transplantation and their impact on immunosuppressive protocols, organ allocation policies, and transplantation outcome...
  30. ncbi The role of innate immunity in acute allograft rejection after lung transplantation
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Respir Crit Care Med 168:628-32. 2003
    ..Therapies directed at inhibition of innate immune responses mediated by TLR4 may represent a novel and effective means to prevent acute rejection after lung transplantation...
  31. ncbi Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice
    M Yamazaki
    Department of Medicine, Division of Diabetes, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Transplant 7:1710-21. 2007
    ..In contrast, chimerism is lost, but skin allografts survive following naïve T-cell injection. We conclude that hematopoietic chimerism and peripheral tolerance may be maintained by different mechanisms in mixed hematopoietic chimeras...
  32. ncbi Impact of donor bone marrow on survival of composite tissue allografts
    Maria Siemionow
    Department of Plastic and Reconstructive Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Plast Surg 60:455-62. 2008
    ..In this review, bone marrow-based therapy protocols of experimental and clinical models are presented in composite tissue transplantation...
  33. ncbi Immunobiology of rejection and adaptation
    H L Trivedi
    Institute of Kidney Diseases and Transplantation Sciences, Gulabben Rasiklal Doshi and Kamlaben Mafatlal Mehta Institute, Research Center and Institute of Civil Hospital Campus, Asarwa Ahmedabad, Gujarat, India
    Transplant Proc 39:647-52. 2007
    ..Adaptation and tolerance are based on the principle of exhaustion of donor-specific immune responses by an activation-deletion-exhaustion pathway...
  34. ncbi Transplantation immunology: what the clinician needs to know for immunotherapy
    Hugo R Rosen
    Division of Gastroenterology and Hepatology, Liver Transplantation, Hepatitis C Center, Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Gastroenterology 134:1789-801. 2008
    ....
  35. pmc Continuous engagement of a self-specific activation receptor induces NK cell tolerance
    Sandeep K Tripathy
    Gastroenterology Division, Department of Medicine, Washington University School of Medicine and Howard Hughes Medical Institute, St Louis, MO 63110, USA
    J Exp Med 205:1829-41. 2008
    ..Thus, engagement of self-specific activation receptors in vivo induces an NK cell tolerance effect that is not affected by self-MHC-specific inhibitory receptors...
  36. ncbi 27. Transplantation immunology: organ and bone marrow
    Rebecca H Buckley
    Department of Pediatrics, Allergy Immunology, Duke University Medical Center, 362 Jones Building Campus Box 2898, Durham, NC 27710 0001, USA
    J Allergy Clin Immunol 111:S733-44. 2003
    ..The major obstacle to the performance of solid organ transplantation currently is the shortage of donor organs...
  37. pmc Heterologous immunity provides a potent barrier to transplantation tolerance
    Andrew B Adams
    Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 111:1887-95. 2003
    ..These data offer a potential explanation for the difficulty encountered when inducing tolerance in nonhuman primates and human patients and provide insight into the signaling pathways essential for memory T cell activation and function...
  38. ncbi Transplant capillaropathy and transplant glomerulopathy: ultrastructural markers of chronic renal allograft rejection
    Bela Ivanyi
    Department of Pathology, University of Szeged, Szeged, Hungary
    Nephrol Dial Transplant 18:655-60. 2003
  39. ncbi The immunological monitoring of alloreactive responses in liver transplant recipients: a review
    Raymond Reding
    Pediatric Liver Transplant Program, Saint Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
    Liver Transpl 12:373-83. 2006
    ..A conceptual framework for the development of tolerance assays in clinical liver transplantation is also proposed...
  40. ncbi Induction of tolerance in clinical organ transplantation
    F Fandrich
    Nephrol Dial Transplant 21:1170-3. 2006
  41. ncbi Tolerance and the "Holy Grail" of transplantation
    Rebecca A Schroeder
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Surg Res 111:109-19. 2003
    ..In this paper, advances in transplant immunology are reviewed and their potential relevance to achieving the "Holy Grail" of transplantation are discussed...
  42. ncbi Composite tissue allografting (CTA)
    Harry J Buncke
    The Buncke Clinic, California Pacific Medical Center, Davies Campus, San Francisco, California, USA
    Surg Technol Int 11:292-302. 2003
    ..The skin, one of the most strongly antigenic organs, has required such high levels of immunosuppressive drugs to date, that elective transplants of skin and other composite tissues have received little attention...
  43. ncbi Is clinical tolerance realistic in the next decade?
    Joanna Ashton-Chess
    INSERM U643 ITERT, Nantes, France
    Transpl Int 19:539-48. 2006
    ..Here, we review this progress made in the quest to achieve clinical tolerance...
  44. ncbi Composite vascularized skin/bone transplantation models for bone marrow-based tolerance studies
    Selahattin Ozmen
    Cleveland Clinic Foundation, Department of Plastic Surgery, OH 44195, USA
    Ann Plast Surg 56:295-300. 2006
    ....
  45. ncbi Use of capecitabine after renal allograft transplantation in dog erythrocyte antigen-matched dogs
    Chad Schmiedt
    Department of Surgical Sciences, College of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706 1102, USA
    Vet Surg 35:113-24. 2006
    ..To investigate the use of a capecitabine (CAP)-based regimen after renal transplantation in dogs...
  46. ncbi Immunosuppression and immune monitoring after renal transplantation
    Martin S Zand
    Nephrology Unit, Kidney and Pancreas Transplant Programs, University of Rochester Medical Center, Rochester, New York 14642, USA
    Semin Dial 18:511-9. 2005
    ..Monitoring assays are discussed, as well as the frequency of monitoring and patient visits. Finally, we discuss several common clinical scenarios that often require adjustment of immunosuppression medications or regimens...
  47. ncbi Steroid-free immunosuppression in organ transplantation
    Gaoxing Luo
    Radiation and Combat Injury Department Code 33, Combat Casualty Care Directorate, Naval Medical Research Center, Silver Spring, MD 20910 6500, USA
    Curr Diab Rep 5:305-10. 2005
    ..In this review, we address the feasibility and benefits of steroid-free and steroid avoidance protocols in kidney, pancreas, liver, and heart transplantation...
  48. ncbi Exploiting tolerance processes in transplantation
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX13RE, UK
    Science 305:209-12. 2004
    ..This would allow the minimization of immunosuppressive treatment and offers the prospect of eventually weaning transplant recipients off their drugs...
  49. ncbi Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol
    Christoph Domenig
    Transplantation Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 175:51-60. 2005
    ..In this model, both deletional and immunoregulatory mechanisms are active during the induction and/or maintenance of allograft tolerance through creation of MC using a potentially clinically applicable regimen...
  50. ncbi JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants
    Dominic C Borie
    Transplantation Immunology Laboratory, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Trends Mol Med 10:532-41. 2004
    ..The recent demonstration in stringent preclinical models that JAK3 inhibition results in efficacy for the prevention of allograft rejection with a narrow side-effect profile might lead to a new era in the field of immunosuppression...
  51. ncbi Chronic induction. What's new in the pipeline
    Flavio Vincenti
    University of California, San Francisco, Calif 94143 0780, USA
    Contrib Nephrol 146:22-9. 2005
    ....
  52. ncbi Steroid or calcineurin inhibitor-sparing immunosuppressive protocols
    Josep M Grinyo
    Servei de Nefrologia, Hospital Universitari de Bellvitge, University of Barcelona, c Feixa Llarga s n, L Hospitalet, Barcelona, Spain
    Contrib Nephrol 146:30-42. 2005
    ....
  53. ncbi Steroid-free lymphocyte depletion protocols. The potential for partial tolerance?
    Jerry McCauley
    Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15215, USA
    Contrib Nephrol 146:43-53. 2005
    ..Despite these limitations, steroid-free lymphocyte depletion may offer an exciting new treatment paradigm...
  54. ncbi Transplantation tolerance. A complex scenario awaiting clinical applicability
    Mohamed H Sayegh
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Mass, USA
    Contrib Nephrol 146:95-104. 2005
    ..immunetolerance.org). In this review we will highlight the promise and challenges of making transplantation tolerance a clinical reality...
  55. ncbi Dendritic cells,tolerance and therapy of organ allograft rejection
    Giorgio Raimondi
    Thomas E Starzl Transplantation Institute and Department of Surgery and Immunology, University of Pittsburgh, PA, USA
    Contrib Nephrol 146:105-20. 2005
    ..Recently identified molecular signaling pathways that play key roles in the outcome of DC-T cell interaction are likely to become novel targets for manipulation of allograft immunity and for the promotion of transplant tolerance...
  56. ncbi Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure
    Kazuo Mizutani
    Terasaki Foundation Laboratory, Los Angeles, California, USA
    Am J Transplant 5:2265-72. 2005
    ..These antibodies found in the peripheral circulation, were not necessarily donor-specific, but their association with failure is consistent with a causality hypothesis...
  57. ncbi Immunosuppression: practice and trends
    Dixon B Kaufman
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Am J Transplant 4:38-53. 2004
    ..Short-term outcomes have improved, based on the observation that rates of rejection within the first year post-transplant have diminished...
  58. ncbi Results of clinical renal transplantation in 15 dogs using triple drug immunosuppressive therapy
    Clare R Gregory
    Comparative Transplantation Laboratory, Department of Surgical and Radiological Sciences and Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 8475, USA
    Vet Surg 35:105-12. 2006
    ..To evaluate outcome of renal transplantation in dogs administered cyclosporine, azathioprine, and prednisolone immunosuppression...
  59. ncbi Individuality: the barrier to optimal immunosuppression
    Barry D Kahan
    Division of Immunology and Organ Transplantation, Department of Surgery, University of Texas Medical School at Houston, Suite 6 240, 6431 Fannin, Houston, Texas 77030, USA
    Nat Rev Immunol 3:831-8. 2003
    ..Approaches presently under investigation aim to alter cell trafficking, or selectively deviate the maturation of antigen-presenting cells or inhibit lymphocyte-activation cascades - events that are crucial to rejection responses...
  60. ncbi Transplantation 50 years later--progress, challenges, and promises
    Mohamed H Sayegh
    Transplantation Research Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 351:2761-6. 2004
  61. ncbi Low circulating regulatory T-cell levels after acute rejection in liver transplantation
    Ahmet Demirkiran
    Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Liver Transpl 12:277-84. 2006
    ..Despite these quantitative differences between rejectors and nonrejectors, the suppressive quality of CD4+CD25+ Tregs is identical in both groups...
  62. ncbi Expression of the chemokine receptor CXCR3 in human renal allografts--a prospective study
    Ute Hoffmann
    Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, Germany
    Nephrol Dial Transplant 21:1373-81. 2006
    ..Since chemokines play pivotal roles in this process, our prospective study was performed to evaluate further the role of the chemokine receptor CXCR3...
  63. ncbi Monitoring of immunosuppressive therapy in renal transplanted patients
    S Chiaramonte
    Department of Nephrology, Dialysis and Transplantation, St Bortolo Hospital, Vicenza, Italy
    Contrib Nephrol 146:73-86. 2005
    ....
  64. pmc Transplant-related immunosuppression: a review of immunosuppression and pulmonary infections
    Michael D Duncan
    Department of Medicine, Indiana University School of Medicine, Van Nuys Medical Sciences Building MS224, 635 Barnhill Dr, Indianapolis, IN 46202 5120, USA
    Proc Am Thorac Soc 2:449-55. 2005
    ..The immunosuppressants involve many classes of drugs, including antibody therapies that eliminate specific groups of cells or alter signaling pathways used by effector cells. The article reviews the agents and associated infections...
  65. ncbi Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients
    Giovanni Stallone
    Department of Biomedical Sciences, Division of Nephrology, University of Foggia, Foggia, Italy
    J Am Soc Nephrol 16:3755-62. 2005
    ..005). This study demonstrates that rapamycin introduction/CNI withdrawal improves graft survival and reduces interstitial and vascular alpha-SMA expression, slowing down the progression of allograft injury in patients with CAN...
  66. ncbi Therapeutic apheresis therapy for ABO-incompatible renal transplantations
    Hideki Ishida
    Department of Urology, Division of Blood Purification, Tokyo Women s Medical University, Tokyo, Japan
    Ther Apher Dial 7:520-8. 2003
    ..In this article, we describe the historical background, the current therapeutic strategies including apheresis therapy for the ABO-incompatible transplantations, and the experiences at our institution...
  67. ncbi Reviewing the mechanism of peripheral tolerance in clinical transplantation
    Nicole Suciu-Foca
    Columbia University, Department of Pathology, New York, NY 10032, USA
    Contrib Nephrol 146:132-42. 2005
  68. ncbi Tolerance assays: measuring the unknown
    Kenneth A Newell
    The Emory Transplant Center and Department of Surgery, Emory University, Atlanta, Georgia 30345, USA
    Transplantation 81:1503-9. 2006
    ..Validation of "tolerance" assays will be critical for the safe development of tolerance regimens in humans...
  69. ncbi Risk factors for late renal allograft dysfunction: effects of baseline glomerular size
    Mingxi Li
    Department of Nephrology, Peking Union Medical College Hospital, Beijing, China
    J Nephrol 15:620-5. 2002
    ..We hypothesized that glomerular hypertrophy is a risk factor for deterioration of allograft function. The goal of this study was to examine the role of glomerular size in predicting late allograft dysfunction...
  70. ncbi Cyclosporine reduction in the presence of everolimus: 3-month data from a Canadian pilot study of maintenance cardiac allograft recipients
    Heather Ross
    Department of Cardiology, Toronto General Hospital, Toronto, Ontario, Canada
    J Heart Lung Transplant 27:197-202. 2008
    ..Data are lacking regarding everolimus with reduced-dose CsA in maintenance cardiac transplant patients...
  71. ncbi Renal transplantation after previous pediatric heart transplantation
    Jyoti Gupta
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Heart Lung Transplant 27:217-21. 2008
    ..An understanding of this strategy is important as many centers are advocating various renal-sparing immunosuppressive regimens-potentially at the cost of increasing heart allograft rejection...
  72. ncbi Mixed chimerism achieved by a nonlethal conditioning regimen induces donor-specific tolerance to lung allografts
    Sen Li
    Department of Surgery, Division of Cardiothoracic Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Surg Res 146:289-97. 2008
    ..The aim of this study was to develop a nonlethal conditioning regimen to induce tolerance to lung allografts...
  73. ncbi Impact of human leucocyte antigen mismatch on graft-versus-host disease and graft failure after reduced intensity conditioning allogeneic haematopoietic stem cell transplantation from related donors
    Takanori Teshima
    Centre for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
    Br J Haematol 130:575-87. 2005
    ..RICT from a one-locus-mismatched donor may represent an effective alternative approach in patients with high-risk malignancies who lack HLA-matched related donors...
  74. ncbi Failure of immunosuppressive drug levels to predict T-cell reactivity in pediatric transplant patients
    Valerie B Sampson
    Nemours Biomedical Research, Molecular Genetics, Cellular and Tissue Transplantation, Wilmington, DE 19803, USA
    J Pediatr Surg 43:1134-41. 2008
    ..Using a Food and Drug Administration-approved test for T-cell response, T-cell activation in vitro can be measured to monitor the immune response...
  75. ncbi The role of mast cells after solid organ transplantation
    Jama Jahanyar
    Michael E DeBakey Department of Surgery, Division of Transplant and Assist Devices, Baylor College of Medicine, Houston, TX 77030, USA
    Transplantation 85:1365-71. 2008
    ..The following review of the literature serves to further define the role of mast cells in the immunologic reactions affecting transplanted solid organ grafts...
  76. ncbi Allorecognition
    I Cote
    Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Transfus Clin Biol 8:318-23. 2001
    ..Consequently, the future challenge in the induction of allograft tolerance is to design interventions that will target the cells involved in the indirect pathway, especially the T cells with indirect allospecificity...
  77. ncbi Transplantation of newborn esophagus: an experimental study
    A Yamataka
    Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan
    J Pediatr Surg 36:1255-7. 2001
    ..These observations suggest that the authors' procedure has the potential to produce viable esophageal tissue that could be a new option for treating long gap esophageal atresia...
  78. pmc Marking a path to transplant tolerance
    Vicki Seyfert-Margolis
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    J Clin Invest 118:2684-6. 2008
    ....
  79. ncbi Hand transplantation in the United States: experience with 3 patients
    Kadiyala V Ravindra
    Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Surgery 144:638-43; discussion 643-4. 2008
    ..Hand transplantation, the most widely recognized form of CTA, aims to improve function and the quality of life of upper limb amputees...
  80. ncbi Humoral responses directed against non-human leukocyte antigens in solid-organ transplantation
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 86:1019-25. 2008
    ....
  81. ncbi Immune cells and immunosuppression in a porcine bronchial model of obliterative bronchiolitis
    P K Maasilta
    Department of Pulmonary Medicine, University of Helsinki, Finland
    Transplantation 72:998-1005. 2001
    ..These results support OB being T-cell mediated. RAD may have additional important effects on growth factors and proliferation in prevention of OB...
  82. pmc Allopeptides and the alloimmune response
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, Box 8109 3328 CSRB, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell Immunol 248:31-43. 2007
    ..In addition, we speculate on the potential of regulatory T cells to modulate alloimmune responses...
  83. ncbi Novelties in diagnostics and therapy of antibody mediated rejection
    Duska Dragun
    Department of Nephrology and Intensive Care Medicine, Charite Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Nephrol Dial Transplant 22:viii50-viii53. 2007
    ..The analysis of the subtle mechanistic and diagnostic differences among rejection subtypes will help to identify patients at particular risk and improve outcome of AMR...
  84. ncbi Advances in composite tissue allograft transplantation as related to the hand and upper extremity
    Maria Siemionow
    Department of Plastic Surgery, The Cleveland Clinic Foundation, A60, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Hand Surg Am 27:565-80. 2002
    ..It is clear that there is a substantial demand for routine use of CTAs but the treatment protocols need to be optimized and the functional outcomes need to be improved...
  85. ncbi CTLA4-Ig-based conditioning regimen to induce tolerance to cardiac allografts
    Sen Li
    Division of Cardiothoracic Surgery, University of Miami School of Medicine, Miami, Florida 33156, USA
    J Surg Res 136:238-46. 2006
    ..In this study, we investigated a non-toxic CTLA4-Ig-based protocol to induce donor-specific tolerance to cardiac allografts in rats...
  86. ncbi Pharmacologic approaches to composite tissue allograft
    Julio A Clavijo-Alvarez
    School of Medicine, University of Pittsburgh, Pittsburgh, PA 05261, USA
    J Hand Surg Am 32:104-18. 2007
    ..There is still a need, however, to reproduce these findings in species phylogenetically closer to humans. This may be the target of future research efforts, which may overcome the challenge of limb and face transplant rejection...
  87. ncbi Anti-CD45RB monoclonal antibody prolongs renal allograft survival in cynomolgus monkeys
    G Chen
    Department of Surgery, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Am J Transplant 7:27-37. 2007
    ..Induction with an anti-CD45RB mAb improves the efficacy of tacrolimus in the prevention of rejection. These encouraging results indicate that an anti-CD45RB mAb may be valuable in future clinical transplantation...
  88. ncbi Xenotransplantation and ABO incompatible transplantation: the similarities they share
    Uri Galili
    Department of Medicine, University of Massachusetts Medical School, LRB, Worcester, MA 01605, USA
    Transfus Apher Sci 35:45-58. 2006
    ..Such tolerance is perpetuated indefinitely by the subsequent transplantation of the organ expressing the incompatible blood group antigen...
  89. ncbi Role of naturally arising regulatory T cells in hematopoietic cell transplantation
    Vu H Nguyen
    Center for Clinical Science Research, Department of Medicine, Division of Bone Marrow Transplantation, Stanford University, Stanford, CA 94305, USA
    Biol Blood Marrow Transplant 12:995-1009. 2006
    ..In this review, we discuss the current knowledge of Treg biology and the potential therapeutic strategies and barriers of Treg immunotherapy in human hematopoietic cell transplantation...
  90. ncbi STEALTH in transplantation tolerance
    Anne Hutchings
    Department of Surgery, University of Alabama at Birmingham, 35294 0012, USA
    Immunol Res 26:143-52. 2002
    ..5% at 3 yr), with some primate recipients remaining in good health more than 6 yr posttransplant, in the complete absence of chronic pharmacologic immunosuppression...
  91. ncbi The spectrum of complications of immunosuppression: is the time right for hand transplantation?
    Michael J Brenner
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Joint Surg Am 84:1861-70. 2002
  92. ncbi Late deterioration of organ transplants: a problem in injury and homeostasis
    Sita Gourishankar
    Division of Nephrology and Immunology, University of Alberta, Edmonton, T6G 2S2, Canada
    Curr Opin Immunol 14:576-83. 2002
    ..The most important recent advance has been the emergence of potent immunosuppressive drug combinations that have greatly reduced rejection...
  93. ncbi WOFIE stimulates regulatory T cells: a 2-year follow-up of renal transplant recipients
    Bettina Dresske
    Department of General and Thoracic Surgery, University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplantation 81:1549-57. 2006
    ..Initial interruption of immunosuppression for 72 hr was analyzed in renal transplant recipients according to Calne et al.'s "window of opportunity for immunologic engagement" (WOFIE) concept...
  94. ncbi Large antigenic skin load in total abdominal wall transplants permits chimerism induction
    Serdar Nasir
    Department of Plastic and Reconstructive Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Plast Surg 61:572-9. 2008
    ..reconstruction is parallel with extended knowledge of anatomy, microsurgical skills and development of transplantation immunology. CTAs are composed of multiple tissues, some of which such as skin are highly immunogenic and cause ..
  95. ncbi A study of HLA-G polymorphism and linkage disequilibrium in renal transplant patients and their donors
    Alessandro Pirri
    Laboratory of Immunogenetics and Histocompatibility LIGH, Department of Genetics, Universidade Federal do Parana, Brazil
    Transpl Immunol 20:143-9. 2009
    The role of the Major Histocompatibility Complex (MHC) in transplantation immunology is widely known...
  96. ncbi Expression of chemokine receptors CCR3, CCR5 and CXCR3 on CD4(+) T cells in CBA/JxDBA/2 mouse model, selectively induced by IL-4 and IL-10, regulates the embryo resorption rate
    Pei juan Jiang
    Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Chin Med J (Engl) 122:1917-21. 2009
    Chemokines and their receptors have been a research focus in transplantation immunology. Chemokines and their receptors play a role in lymphocyte recruitment and differentiation process...
  97. ncbi Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology
    J H Lai
    Department of Medicine, Tri Service General Hospital, Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Transplantation 68:1383-92. 1999
    ..Here, we examined its effects on several CD28-costimulated T-cell activities. In addition, such effects were readily compared with the effects of three tetrandrine analogs...
  98. ncbi [Studies on the induction of transplantation tolerance and immune reconstitution through combined strategies]
    Shusheng Xie
    Department of Immunology, Peking University School of Basic Medical Sciences, Beijing 100083, China
    Beijing Da Xue Xue Bao 39:547-9. 2007
    ..bone marrow transplantation are the main research fields in the clinic organ transplantation and transplantation immunology. Over the past 5 years serial studies have been performed in our lab to induce robust transplantation ..
  99. ncbi [Basic and clinical research in the field of burn wound healing]
    Shu liang Lu
    Department of Burns, Ruijin Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200025, P R China
    Zhonghua Shao Shang Za Zhi 24:359-61. 2008
    ..The induction of local immune tolerance has now become the research hot subject of skin transplantation immunology. Stem cell research in the field of wound healing has been extensively carried out...
  100. ncbi Themes of liver transplantation
    Thomas E Starzl
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 51:1869-84. 2010
    ..and the acquired tolerance of bone marrow transplantation and eventually clarified the relationship of transplantation immunology to the immunology of infections, neoplasms, and autoimmune disorders...
  101. ncbi Manipulation of CD45 antigen in transplantation tolerance
    Saiho Ko
    First Department of Surgery, Nara Medical University, Kashihara, Japan
    Curr Mol Med 2:249-55. 2002
    ..is not only a target molecule for tolerance induction, but also an useful tool for experimental models in transplantation immunology. In this review, we introduce basic properties of CD45 and recent results with manipulation of CD45.

Research Grants62

  1. RESEARCH TRAINING IN RESPIRATORY BIOLOGY
    Anne I Sperling; Fiscal Year: 2013
    ..Fibrosis/Luna Transplantation that focuses on cellular and molecular mechanisms of fibrosis and on transplantation immunology. Studies in Critical Illness continue to address subcellular determinants of oxygen sensing and ..
  2. VIRAL INFECTION INFLUENCE ON TRANSPLANTATION TOLERANCE
    DALE LESLIE GREINER; Fiscal Year: 2013
    ..Project 4 will bridge between murine studies of Projects 1-3 and human transplantation immunology. The project will study common human viruses known to affect human allograft survival using "humanized ..
  3. MicroRNA regulation of human T and B cell activation
    Daniel R Salomon; Fiscal Year: 2013
    ..When this evolution is accomplished, we will have a new understanding of transplantation immunology, discover a new generation of biomarkers and identify the next generation of potential drug targets.
  4. Vascular Endothelium Directs the Development of Regulatory T Cells
    Daniel Kreisel; Fiscal Year: 2010
    ..The candidate has learned skills in basic immunological research with a special focus on transplantation immunology. This award will provide support needed to develop the foundation of knowledge and skills required for ..
  5. Training Grant in Academic Nephrology
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2013
    ..In addition, there is a large program in clinical and translational transplantation immunology. Clinical research opportunities include epidemiological and patient-oriented investigations in chronic ..
  6. TRAINING IN TRANSPLANTATION BIOLOGY
    David H Sachs; Fiscal Year: 2012
    ..training young investigators, have been assembled to provide trainees with exposure to topics related to transplantation immunology including immunogenetics, tolerance induction, antigen processing and presentation, gene therapy, ..
  7. CAREER DEVELOPMENT IN PEDIATRIC AND MEDICAL ONCOLOGY
    Irwin D Bernstein; Fiscal Year: 2013
    ..abstract_text> ..
  8. Montagna Symposium on the Biology of Skin
    Molly F Kulesz-Martin; Fiscal Year: 2013
    ..Topics planned include "High Impact Science from Studies of the Skin (cancer;transplantation immunology;intermediate filaments;stem cells, tissue engineering and artificial organs)", "Skin Cytoskeleton in ..
  9. Lymphocyte Activation and Gene Expression
    Andrew D Robertson; Fiscal Year: 2010
    ..relevance to a number of clinically important areas, including autoimmunity, immunodeficiency diseases, transplantation immunology, tumor immunology, infectious diseases, and chronic inflammation...
  10. IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGY
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2013
    ..models of immune function;immunogenetics;host responses to infectious diseases, mucosal immunology, transplantation immunology, neuroimmunology, and bioinformatics...
  11. Genomics for Transplantation: Discovery and Biomarkers
    Daniel R Salomon; Fiscal Year: 2013
    ..proteomics and genetics and applying these tools rigorously and critically to the major challenges of transplantation immunology and biology...
  12. Mechanisms of TLR-mediated prevention of transplantation tolerance
    Maria Luisa Alegre; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): One major goal in transplantation immunology is to develop new immunosuppressive agents with the potential to induce donor-specific tolerance and thus avoid increased risk of infection and cancer in ..
  13. Lymphoid Structure in Tolerance: Role of Stromal Cells
    Jonathan S Bromberg; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Achieving tolerance remains the most important goal in transplantation immunology. Models of tolerance employing co-stimulatory blockade are among the most robust and clinically relevant approaches...
  14. 2012 ASN Advances in Research Conference: Auto and Alloimmunity
    Fadi G Lakkis; Fiscal Year: 2013
    ..will have the chance to interact with world leaders in fundamental immunology, autoimmunity, and transplantation immunology and will be exposed to state-of-the-art research...
  15. RESEARCH TRAINING IN TRANSFUSION MEDICINE
    II WHITE; Fiscal Year: 2012
    ..trainees are expected to pursue academic careers in transfusion science or a closely related discipline such as immunohematology, transplantation immunology, vascular biology, hemostasis/thrombosis or stem cell biology.
  16. Training Program in Transplantation
    Haval Shirwan; Fiscal Year: 2013
    ..by applicant): This is a resubmission of a competing renewal for a highly successful training program in transplantation immunology and stem cell biology...
  17. MOLECULAR AND BIOCHEMICAL ANALYSIS OF THE CANINE MHC
    John Wagner; Fiscal Year: 2001
    ..Of paramount importance to comprehending immune-related diseases and transplantation immunology is an understanding of the MHC...
  18. P-glycoprotein Function in Allograft Rejection
    Markus Frank; Fiscal Year: 2004
    ..an ideal environment to accomplish the aims of this project because of their strong background in transplantation immunology, their collaborative momentum and their exemplary didactic and ethical curricula...
  19. Transplantation Immunology Conference
    Angus Thomson; Fiscal Year: 2002
    This is an application for partial funding of a conference on "Transplantation Immunology" that will be held under the auspices of FASEB at Vermont Academy, Saxton's River, Vermont, June 15-20, 2002...
  20. DIFFERENTIAL SCREENING OF TRYPANOSOMA CRUZI ANTIGENS
    JOHN DONELSON; Fiscal Year: 2001
    ..These patients have been studied in the Transplantation Immunology Laboratory of the Sao Paulo University Hospital since 1990...
  21. Complement C1q Function in Allogeneic Transplantation
    Kenneth Christopher; Fiscal Year: 2009
    ..the investigator resources to expand his research skills to develop into an independent investigator in transplantation immunology. David L. Perkins, M.D., Ph.D. will mentor the principal investigator's scientific development. Dr...
  22. Conference Proposal: Transplantation Immunology
    Angus Thomson; Fiscal Year: 2004
    This is an application for partial funding of a conference on "Transplantation Immunology" that will be held under the auspices of FASEB at Snowmass Village, Colorado June 19-24, 2004...
  23. The CD40-CD154 pathway in chronic allograft rejection
    Anil Chandraker; Fiscal Year: 2005
    ..The applicant will utilize his background in the field of transplantation immunology and build o previous studies carried by the applicant and others...
  24. SIXTH BASIC SCIENCE SYMPOSIUM OF TRANSPLANTATION
    SHERI KRAMS; Fiscal Year: 1999
    ..Symposium is to promote scientific interaction and the informal exchange of recent developments in transplantation immunology among investigators in scientific disciplines that impact clinical and experimental transplantation...
  25. CANCER AND LEUKEMIA GROUP B--MINNESOTA ONCOLOGY GROUP
    Bruce Peterson; Fiscal Year: 2002
    ..The objective of this research program is to participate in inter-institutional clinical research to resolve unanswered and important questions in the therapy and biology of malignant diseases. ..
  26. SKIN-SPECIFIC ALLOANTIGENS
    DAVID STEINMULLER; Fiscal Year: 1991
    ..The first long-term objective of this project is to further elucidate the immunogenetics and transplantation immunology of Epa alloantigens, including: (1) mapping the Epa-1 gene locus with a new set of recombinant-inbred ..
  27. The Cytoskeleton, Rafts and the Interleukin-2 Receptor
    Jens Goebel; Fiscal Year: 2005
    ..The applicant's training towards becoming an independent scientist with a focus in transplantation immunology will be fostered in the process through continued mentoring by two established immunologists and ..
  28. Stem Cell-Derived Immunotherapy: Proof of Principle
    Daniel Kraft; Fiscal Year: 2009
    ..program will promote the development of skills in hematopoietic stem cell biology as applied towards transplantation immunology and development of a novel strategy of hematopoietic stem cell (HSC) derived immunotherapy. Dr...
  29. Training in Transplantation Immunology
    Kenneth Christopher; Fiscal Year: 2003
    ..In AIM 2, we will analyze the lymph node dependent immune activation of recipient T cells following transplantation. ..
  30. CELLULAR CARDIAC ALLOGRAFT REJECTION
    Biagio Pietra; Fiscal Year: 2000
    ....
  31. REGULATORY ABNORMALITIES IN IMMUNOLOGIC DISEASES
    Robert Rich; Fiscal Year: 1991
    ..and scientific expertise in human and murine immunogenetics, immunochemistry, cellular immunology, transplantation immunology and viral immunology...
  32. TRAINING PROGRAM IN PEDIATRIC IMMUNOLOGY
    ANTHONY HAYWARD; Fiscal Year: 1999
    ..There are correlated seminars in autoimmunity, immunopathology, immunodeficiency, immunity to an infectious agent, and transplantation immunology.
  33. PHARMACOLOGY OF CYCLOSPORINE BASED IMMUNOSUPPRESSION
    Barry Kahan; Fiscal Year: 2004
    ....
  34. CD8+ Memory T Cell Subsets in Transplantation
    Geetha Chalasani; Fiscal Year: 2007
    ..The candidate is committed to a physician-scientist career in transplantation immunology and nephrology and to pursuing fundamental immunology questions in memory T cell biology. ..
  35. SNPs in Lung Cancer Risk and Therapeutic Response
    Effie Petersdorf; Fiscal Year: 2004
    ..abstract_text> ..
  36. OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORS
    Effie Petersdorf; Fiscal Year: 2003
    ....
  37. Immunosupression-Resistant Gene Modified Donor T Cells
    George Georges; Fiscal Year: 2009
    ..Results from these studies have the strong potential to be directly translated to future gene therapy clinical trials. ..
  38. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  39. Improving Platelet Recovery After Radiation
    George Georges; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. TRANSPLANTATION IMMUNOLOGY
    Anita Chong; Fiscal Year: 2008
    ..provided by applicant): [unreadable] This is an application for partial funding of a conference on "Transplantation Immunology" that will be held under the auspices of FASEB in New Haven, Connecticut, July 13-18, 2008...
  41. Gene Modified Donor T Cell Infusion into Mixed Chimeras
    George Georges; Fiscal Year: 2003
    ..If successful, this study could translate into improved control of the GVH reaction and improved survival after allogeneic HCT. ..
  42. PREVENTING ANTI-GAL PRODUCTION AGAINST XENOGRAFTS
    Uri Galili; Fiscal Year: 2003
    ..Success in these studies will help in planning effective treatments for preventing anti-Gal response in primate xenografts recipients. | ..
  43. ORTHOTOPIC LIVER TRANSPLANTATION
    Thomas Starzl; Fiscal Year: 2001
    ..Moreover, the investigators will attempt to develop novel techniques to modify the number and character of the donor cells that ultimately reside in the recipient and promote tolerance to the allograft. ..
  44. GENE MODIFIED T-CELLS FOR ENGRAFTMENT AND GVHD CONTROL
    George Georges; Fiscal Year: 2003
    ..We will test if donor CTL specific for host minor histocompatibility antigens can convert mixed to complete donor chimerism. If successful this would make MHC-matched stem cell transplantation less toxic. ..
  45. Improving Gastrointestinal Recovery after Radiation
    George Georges; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  46. INCREASE/gp120 IMMUNOGENICITY/LINKED ALPHA-GAL EPITOPES
    Uri Galili; Fiscal Year: 2005
    ..We will then also collaborate with a group studying immune responses in monkeys to determine the efficacy of this vaccine in a primate model. ..
  47. Cytokines for Immune Protection from Acute Irradiation
    George Georges; Fiscal Year: 2005
    ..The secondary endpoint is immune reconstitution. Upon study completion, we will have identified the optimal cytokine treatment and the highest dose of TBI that can be reliably survived without HSC support. ..
  48. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006
    ..This work has important implications for the selective inactivation of gene function in allografts through ex vivo gene transfer. ..
  49. Defining Biomarkers in Pediatric Renal Transplantation
    Minnie Sarwal; Fiscal Year: 2007
    ..The genomic and tissue microarray databases will be made publicly available for the academic community to facilitate future large-scale collaborative studies. [unreadable] [unreadable] [unreadable] [unreadable]..
  50. MOLECULAR MODEL FOR T-CELL RECEPTOR LIGAND INTERACTIONS
    Nilabh Shastri; Fiscal Year: 2007
    ..We expect the findings to reveal new insights into the nature of endogenous peptides presented by MHC class II and MHC class I molecules in normal cells as well as fundamental issues in transplantation immunology.
  51. Graft Tolerance with Apoptotic Cells and Dendritic Cells
    ADRIAN MORELLI; Fiscal Year: 2008
    ..Aim 3; To optimize the therapeutic effect of donor apoptotic cells on heart allograft survival. To investigate the mechanism(s) of action of donor apoptotic cells in graft recipients. ..
  52. Dendritic Cells with Galectin-1 to Enhance Islet Grafts
    ADRIAN MORELLI; Fiscal Year: 2003
    ..The results may have an important impact on regulation of beta-cell autoimmunity and in other areas of transplantation. ..
  53. MIXED CHIMERISM IN MINIATURE SWINE
    David Sachs; Fiscal Year: 2002
    ..abstract_text> ..
  54. ISLET-KIDNEY TRANSPLANTS FOR TREATMENT OF DIABETIC ESRD
    David Sachs; Fiscal Year: 2003
    ..We anticipate that the use of pre-vascularized islets as part of a composite islet-kidney transplant may provide a new and effective treatment modality for patients with class I diabetes and end-stage renal disease. ..
  55. Role of Innate Immunity in Transplantation Tolerance
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2010
    ..g., MyD88 blockade at the time of tolerance induction). ..