antigen presentation

Summary

Summary: The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)

Top Publications

  1. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
  2. ncbi Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology, Friedrich Wilhelms Universität, Bonn, Germany
    Science 316:612-6. 2007
  3. ncbi Immunobiology of dendritic cells
    J Banchereau
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Annu Rev Immunol 18:767-811. 2000
  4. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
  5. doi Towards a systems understanding of MHC class I and MHC class II antigen presentation
    Jacques Neefjes
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nat Rev Immunol 11:823-36. 2011
  6. ncbi Mouse and human dendritic cell subtypes
    Ken Shortman
    Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    Nat Rev Immunol 2:151-61. 2002
  7. doi High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway
    Kosuke Yoshihara
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Cancer Res 18:1374-85. 2012
  8. pmc Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
    Dorothee Schmid
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Immunity 26:79-92. 2007
  9. pmc Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas
    Jackson G Egen
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:807-19. 2011
  10. pmc Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation
    Radhika Goenka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 187:1091-5. 2011

Research Grants

  1. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
  2. DHAN V KALVAKOLANU; Fiscal Year: 2014
  3. Roy Curtiss Iii; Fiscal Year: 2016
  4. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
  5. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
  6. Richard J Samulski; Fiscal Year: 2014
  7. Veena Taneja; Fiscal Year: 2014
  8. Frances M Brodsky; Fiscal Year: 2014
  9. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
  10. Michael D Cahalan; Fiscal Year: 2016

Detail Information

Publications397 found, 100 shown here

  1. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
    ..We conclude that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness...
  2. ncbi Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology, Friedrich Wilhelms Universität, Bonn, Germany
    Science 316:612-6. 2007
    ..These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis...
  3. ncbi Immunobiology of dendritic cells
    J Banchereau
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Annu Rev Immunol 18:767-811. 2000
    ..Although our understanding of DC biology is still in its infancy, we are now beginning to use DC-based immunotherapy protocols to elicit immunity against cancer and infectious diseases...
  4. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
    ....
  5. doi Towards a systems understanding of MHC class I and MHC class II antigen presentation
    Jacques Neefjes
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nat Rev Immunol 11:823-36. 2011
    ..Here we present a timely evaluation of the biology of antigen presentation and a survey of issues that are considered unresolved...
  6. ncbi Mouse and human dendritic cell subtypes
    Ken Shortman
    Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    Nat Rev Immunol 2:151-61. 2002
    ..Therefore, we must study the dynamics of the DC network in response to microbial invasion. Despite the difficulty of comparing the DC systems of humans and mice, recent work has revealed much common ground...
  7. doi High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway
    Kosuke Yoshihara
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Cancer Res 18:1374-85. 2012
    ..Our aim was to establish a novel risk classification system based on a gene expression signature for predicting overall survival, leading to suggesting novel therapeutic strategies for high-risk patients...
  8. pmc Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
    Dorothee Schmid
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Immunity 26:79-92. 2007
    ..We suggest that macroautophagy constitutively and efficiently delivers cytosolic proteins for MHC class II presentation and can be harnessed for improved helper T cell stimulation...
  9. pmc Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas
    Jackson G Egen
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:807-19. 2011
    ..Here we investigate relationships among antigen presentation, T cell motility, and local production of effector cytokines by CD4+ T cells within hepatic granulomas ..
  10. pmc Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation
    Radhika Goenka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 187:1091-5. 2011
    ....
  11. pmc Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors
    Clifford V Harding
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 7288, USA
    Nat Rev Microbiol 8:296-307. 2010
    ..TLR2)-dependent inhibition of MHC class II transactivator expression, MHC class II molecule expression and antigen presentation. This reduction of antigen presentation might reflect a general mechanism of negative-feedback regulation ..
  12. doi Cancer immunotherapy by dendritic cells
    Cornelis J M Melief
    Department of Immunohematology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands ISA Pharmaceuticals, 3723 MB Bilthoven, The Netherlands
    Immunity 29:372-83. 2008
    ..Here, I discuss the considerations for generating promising therapeutic antitumor vaccines that use DCs...
  13. pmc Mice completely lacking immunoproteasomes show major changes in antigen presentation
    Eleanor Z Kincaid
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 13:129-35. 2011
    The importance of immunoproteasomes to antigen presentation has been unclear because animals totally lacking immunoproteasomes had not been available...
  14. doi Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology, Friedrich Wilhelms University, 53105 Bonn, Germany
    Nat Immunol 9:558-66. 2008
    ..Thus, cross-presentation is spatially and mechanistically separated from endogenous MHC class I-restricted antigen presentation and is biased toward antigens containing microbial molecular patterns.
  15. doi Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Sammy Bedoui
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 10:488-95. 2009
    ..This indicates CD103(+) DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs...
  16. ncbi Tolerogenic dendritic cells
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021 6399, USA
    Annu Rev Immunol 21:685-711. 2003
    ..We suggest that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs...
  17. doi The CD8+ dendritic cell subset
    Ken Shortman
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Rev 234:18-31. 2010
    ..Targeting vaccine antigens to the CD8(+) DCs has proved an effective way to induce cytotoxic T lymphocytes and antibody responses...
  18. pmc Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    Elena Galkina
    Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 203:1273-82. 2006
    ..Atherosclerosis induces the recruitment of macrophages and dendritic cells that support antigen presentation.
  19. pmc In vivo requirement for Atg5 in antigen presentation by dendritic cells
    Heung Kyu Lee
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 32:227-39. 2010
    ..However, the role of autophagic process in antigen presentation in vivo is unclear...
  20. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
    ..These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity...
  21. ncbi Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    Casper Paludan
    Laboratory of Viral Immunobiology, Rockefeller University, New York, NY 10021, USA
    Science 307:593-6. 2005
    ..Thus, lysosomal processing after autophagy may contribute to MHC class II-restricted surveillance of long-lived endogenous antigens including nuclear proteins relevant to disease...
  22. pmc Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation
    Jarish N Cohen
    Department of Microbiology and Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Exp Med 207:681-8. 2010
    ..These results establish lymphatic endothelial cells, and potentially other LN-resident cells, as systemic mediators of peripheral immune tolerance...
  23. doi MHC class I antigen presentation: learning from viral evasion strategies
    Ted H Hansen
    Washington University School of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA
    Nat Rev Immunol 9:503-13. 2009
    ..However, in turn, viruses have evolved elegant strategies to inhibit various stages of the MHC class I antigen presentation pathway and prevent the display of viral peptides...
  24. ncbi Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
    Melanie Greter
    Neuroimmunology Unit, Department of Neurology, University Hospital Zurich, Frauenklinkstrasse 10, CH 8091 Switzerland
    Nat Med 11:328-34. 2005
    ..In mice, CD11c+ DCs alone are sufficient to present antigen in vivo to primed myelin-reactive T cells in order to mediate CNS inflammation and clinical disease development...
  25. pmc Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
    Eric A Reits
    Division of Tumor Biology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands
    J Exp Med 203:1259-71. 2006
    Radiotherapy is one of the most successful cancer therapies. Here the effect of irradiation on antigen presentation by MHC class I molecules was studied...
  26. doi NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    Rachel Cooney
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Headington, Oxford, UK
    Nat Med 16:90-7. 2010
    ..as a bacterial sensor in dendritic cells (DCs), but it is not clear how bacterial recognition links with antigen presentation after NOD2 stimulation...
  27. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
    ....
  28. doi Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients
    Carlos del Fresno
    Research Unit, Laboratory of Tumor Immunology, La Paz Hospital, Madrid, Spain
    J Immunol 182:6494-507. 2009
    ..Our results indicate that a tolerant phenotype interferes with timing, efficiency, and outcome of the innate immune responses against bacterial infections...
  29. doi Antigen presentation in the thymus for positive selection and central tolerance induction
    Ludger Klein
    Institute for Immunology, Ludwig Maximilians University, Goethestrasse 31, 80336 Munich, Germany
    Nat Rev Immunol 9:833-44. 2009
    ..cells and the intercellular transfer of self antigens have uncovered surprising and unique aspects of antigen presentation in the thymic microenvironment...
  30. pmc HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide
    Anne Kathrin Anders
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:54-61. 2011
    ..HLA-DM thus binds only to HLA-DR conformers in which a critical part of the binding site is already vacant because of spontaneous peptide motion...
  31. pmc The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes
    Brian A Walker
    Institute for Animal Health, Compton RG20 7NN, United Kingdom
    Proc Natl Acad Sci U S A 108:8396-401. 2011
    ..polymorphic and determine the specificity of peptide presentation, whereas the transporter associated with antigen presentation (TAP) heterodimers are functionally monomorphic...
  32. pmc The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice
    Santiago Zelenay
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK
    J Clin Invest 122:1615-27. 2012
    ..The identification of specialized receptors that regulate antigenicity of virus-infected cells reveals determinants of antiviral immunity that might underlie the human response to infection and vaccination...
  33. pmc Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation
    Laura K Mackay
    Department of Microbiology and Immunology, University of Melbourne, Melbourne 3010, Australia
    Proc Natl Acad Sci U S A 109:7037-42. 2012
    ..The results demonstrate that peripheral T(RM) cells can be generated and survive in the absence of local antigen presentation and provide a powerful means of achieving immune protection against peripheral infection.
  34. doi CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation
    Andreas J Müller
    Dynamics of Immune Responses, Institut Pasteur, Paris, France
    Immunity 37:147-57. 2012
    ..that this effector bystander activity extends via a gradient of IFN-γ more than 80 μm beyond the site of antigen presentation, promoting pathogen clearance in the absence of immunological synapse formation...
  35. ncbi B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node
    Yolanda R Carrasco
    Lymphocyte Interaction Laboratory, Cancer Research United Kingdom London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 27:160-71. 2007
    ..These observations not only provide evidence of a B cell role as antigen transporters into the follicle, but also highlight the boundary between the follicle and the SCS as a site for initiation of B cell responses...
  36. pmc Conduits mediate transport of low-molecular-weight antigen to lymph node follicles
    Ramon Roozendaal
    Departments of Pediatrics and Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 30:264-76. 2009
    ..This pathway could be used for enhancing delivery of vaccines or small molecules for improvement of humoral immunity...
  37. doi Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance
    Maria Hinterberger
    Institute for Immunology, Ludwig Maximilians Universitat, Munich, Germany
    Nat Immunol 11:512-9. 2010
    ..Our data document an autonomous contribution of mTECs to both dominant and recessive mechanisms of CD4(+) T cell tolerance and support an avidity model of T(reg) cell development versus deletion...
  38. ncbi Reversal of the TCR stop signal by CTLA-4
    Helga Schneider
    Cell Signalling Section, Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    Science 313:1972-5. 2006
    ..These results suggest a fundamentally different model of reverse stop signaling, by which CTLA-4 modulates the threshold for T cell activation and protects against autoimmunity...
  39. pmc Respiratory syncytial virus-induced activation and migration of respiratory dendritic cells and subsequent antigen presentation in the lung-draining lymph node
    Michael V Lukens
    Department of Pediatrics, the Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    J Virol 83:7235-43. 2009
    ..We also tracked the migration of respiratory DC to the lymph nodes and studied antigen presentation by lung-derived and lymph node-resident DC to CD4(+) and CD8(+) T cells...
  40. pmc Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells
    Lynette Beattie
    Department of Biology, Centre for Immunology and Infection, Hull York Medical School, University of York, York, United Kingdom
    PLoS Pathog 6:e1000805. 2010
    ..This restriction of antigen presentation to KCs within the Leishmania granuloma has important implications for the identification of new candidate ..
  41. doi Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress
    Ulrike Seifert
    Institut für Biochemie CC2, Charite Universitatsmedizin Berlin, Oudenarder Strasse 16, D 13347 Berlin, Germany
    Cell 142:613-24. 2010
    ..findings suggest that rather than having a specific role in the production of class I antigens, i-proteasomes increase the peptide supply for antigen presentation as part of a more general role in the maintenance of protein homeostasis.
  42. ncbi The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    Koichi Tabeta
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 7:156-64. 2006
    ..Innate responses to nucleic acids and exogenous antigen presentation, which both initiate in endosomes, thus seem to depend on an endoplasmic reticulum-resident protein, which ..
  43. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo...
  44. ncbi Characterization of human blood dendritic cell subsets
    Kelli P A MacDonald
    Dendritic Cell Laboratory, Mater Medical Research Institute, Mater Misericordiae Hospitals, South Brisbane, Australia
    Blood 100:4512-20. 2002
    ..These data provide an opportunity to standardize the DC populations used for future molecular, functional and possibly even therapeutic studies...
  45. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
    ..Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response...
  46. ncbi The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
    ..to a multivesicular endosomal compartment that resembles the MHC class II-containing vesicles implicated in antigen presentation. Rabbit antibodies that bind DEC-205 are presented to reactive T-cell hybridomas 100-fold more efficiently ..
  47. doi Viral evasion of T cell immunity: ancient mechanisms offering new applications
    Danielle Horst
    Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Immunol 23:96-103. 2011
    ..Moreover, viral immune evasion proteins constitute extremely useful tools to block defined stages of the MHC class I presentation pathway, not only for research purposes, but also for clinical applications...
  48. doi Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells
    Louise J Young
    The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria 3050, Australia
    Nat Immunol 9:1244-52. 2008
    ..As the antigen-presenting abilities of cDCs and pDCs are fundamentally distinct, these two cell types may activate largely nonoverlapping repertoires of CD4(+) T cells...
  49. pmc Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA
    Science 328:102-6. 2010
    ..of CD8+ T cell immunity by virally encoded inhibitors of major histocompatibility complex class I (MHC-I) antigen presentation, particularly the homologs of human CMV US2, 3, 6, and 11...
  50. ncbi Toward an understanding of NKT cell biology: progress and paradoxes
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Annu Rev Immunol 23:877-900. 2005
    ..Despite this uncertainty, many investigators are hopeful that immune therapies can be developed based on NKT cell stimulation...
  51. ncbi MHC class I expression in mice lacking the proteasome subunit LMP-7
    H J Fehling
    Basel Institute for Immunology, Switzerland
    Science 265:1234-7. 1994
    ..encoded in a region of the major histocompatibility complex (MHC) that is critical for class I-restricted antigen presentation. Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface ..
  52. ncbi Antigen presentation and T cell development in H2-M-deficient mice
    W P Fung-Leung
    R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    Science 271:1278-81. 1996
    ..Their CD4+ cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells...
  53. ncbi The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 168:2118-26. 2002
    ..These data point to a novel function of the adhesion receptor DC-SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity...
  54. pmc The Toxoplasma gondii peptide AS15 elicits CD4 T cells that can control parasite burden
    Harshita Satija Grover
    Division of Immunology and Pathogenesis, Department of Molecular and Cellular Biology, University of California, Berkeley, California, USA
    Infect Immun 80:3279-88. 2012
    ....
  55. ncbi Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing
    Britta Strehl
    Institut fur Biochemie, Charite, Berlin University Berlin, Germany
    Immunol Rev 207:19-30. 2005
    ..proteolytic cascade generates larger amounts of appropriate antigenic peptides, assuring more peptides to overcome the proteolytic restrictions of the constitutive system, thereby enhancing MHC class I antigen presentation.
  56. doi Antigen processing and presentation: TAPping into ABC transporters
    Erik Procko
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Immunol 21:84-91. 2009
    ....
  57. doi Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions
    Erietta Stelekati
    Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    Immunity 31:665-76. 2009
    ..Thus, MCs are important players in antigen-specific regulation of CD8(+) T cells...
  58. ncbi Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells
    Giuseppe Gerna
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    J Gen Virol 86:275-84. 2005
    ..DC incubated with inactivated crude whole viral antigen preparations were only capable of eliciting a significant CD4+-mediated immune response...
  59. pmc Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence
    Woelsung Yi
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Clin Invest 120:1324-36. 2010
    ..These studies show that DO expression can shape the overall MHCII self-peptide repertoire to promote T cell tolerance...
  60. doi Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing
    Loredana Cifaldi
    Oncohaematology Department, IRCCS, Ospedale Pediatrico Bambino Gesu, Rome, Italy
    Cancer Res 71:1597-606. 2011
    ..Because a large fraction of human tumors express high levels of the homologous ERAP1 and/or ERAP2, the present findings highlight a convenient, novel target for cancer immunotherapy...
  61. pmc Immunosuppressive strategies that are mediated by tumor cells
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Buenos Aires, Argentina
    Annu Rev Immunol 25:267-96. 2007
    ..different strategies employed by tumors to thwart immune responses, including tumor-induced impairment of antigen presentation, the activation of negative costimulatory signals, and the elaboration of immunosuppressive factors...
  62. ncbi The interaction of HIV with dendritic cells: outcomes and pathways
    Vincent Piguet
    Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland
    Trends Immunol 28:503-10. 2007
    ..Here we review the literature covering these areas, including current knowledge of underlying mechanisms or pathways...
  63. doi Direct antigen presentation and gap junction mediated cross-presentation during apoptosis
    Baoxu Pang
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Immunol 183:1083-90. 2009
    ..We thus define a novel phase in classical Ag presentation and cross-presentation by MHC class I molecules: presentation of Ags created by caspase activities in cells in apoptosis...
  64. ncbi Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway
    T Miyazaki
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, France
    Cell 84:531-41. 1996
    ..Peripheral T cells reacted strongly to splenocytes from syngeneic wild-type mice, no doubt reflecting the unique peptide complement carried by class II molecules in mutant animals...
  65. ncbi Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival
    P Bertolino
    Ecole Normale Superieure de Lyon, UMR 49, France
    Eur J Immunol 28:221-36. 1998
    ..The importance of these findings for the understanding of peripheral tolerance and the ability of liver grafts to be accepted is discussed...
  66. doi Endocytosis mechanisms and the cell biology of antigen presentation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology IMMEI, Friedrich Wilhelms Universität, Bonn, Germany
    Curr Opin Immunol 20:89-95. 2008
    ....
  67. doi Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity
    Nadia R Cohen
    Harvard Division of Medical Sciences, Graduate Program in Immunology, Boston, Massachusetts, USA
    Adv Immunol 102:1-94. 2009
    ..In this review, we describe the pathways and mechanisms of lipid antigen binding and presentation by CD1 in detail, as well as the diverse roles played by CD1-restricted T cells in the context of microbial infection...
  68. ncbi Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:575-85. 2000
    ..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
  69. ncbi Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate
    Lelia Delamarre
    Department of Cell Biology and Department of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520 8002, USA
    Science 307:1630-4. 2005
    ..Limited lysosomal proteolysis also favored antigen presentation. These results help explain why DCs are able to efficiently accumulate, process, and disseminate antigens ..
  70. doi Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells
    Marcus Gereke
    Immune Regulation Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Am J Respir Crit Care Med 179:344-55. 2009
    ....
  71. pmc Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens
    W Chen
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 193:1319-26. 2001
    ..These findings indicate that in addition to their effects on the presentation of foreign antigens, immunoproteasomes influence T(CD8+) responses by modifying the repertoire of responding T(CD8+)...
  72. pmc Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo
    Joke M M den Haan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 7370, USA
    J Exp Med 196:817-27. 2002
    ..Cross-presentation of immune complexes may play an important role in autoimmune diseases and the therapeutic effect of antitumor antibodies...
  73. ncbi An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
    Tomo Saric
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 3:1169-76. 2002
    ..Like other proteins involved in antigen presentation, ERAP1 is induced by interferon-gamma...
  74. ncbi Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo
    Lianjun Shen
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Immunity 21:155-65. 2004
    ..Therefore, cathepsin S plays a major role in generating presented peptides for the vacuolar pathway of crosspresentation, and this mechanism is active in vivo...
  75. ncbi Cell surface recycling of internalized antigen permits dendritic cell priming of B cells
    Amy Bergtold
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Immunity 23:503-14. 2005
    ..Thus dendritic cells are equipped with both non-degradative and degradative antigen uptake pathways to facilitate antigen presentation to both B and T cells.
  76. ncbi B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
    Veronique Angeli
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Immunity 24:203-15. 2006
    ..Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination...
  77. ncbi Immature, but not inactive: the tolerogenic function of immature dendritic cells
    Karsten Mahnke
    Department of Dermatology and Institute of Immunology, University of Mainz, Germany
    Immunol Cell Biol 80:477-83. 2002
    ..This review summarizes the current knowledge about the immunoregulatory role of immature DC that might act as guardians for the induction and maintenance of T cell tolerance in the periphery...
  78. pmc Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I
    Tiziana Di Pucchio
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, Texas 75204, USA
    Nat Immunol 9:551-7. 2008
    ..Our data demonstrate that pDCs use 'ready-made' stores of MHC class I to rapidly present exogenous antigen to CD8+ T cells...
  79. doi Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance
    Stefan Tenzer
    Institute of Immunology, University of Mainz, Mainz, Germany
    Nat Immunol 10:636-46. 2009
    ..Our analyses show that antigen processing shapes CTL response hierarchies and that viral evolution modifies cleavage patterns and suggest strategies for in vitro vaccine optimization...
  80. ncbi The nature of the MHC class I peptide loading complex
    P Cresswell
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Immunol Rev 172:21-8. 1999
    ..These include the two subunits of the transporter associated with antigen presentation (TAP1 and TAP2), which are essential for introducing peptides into the ER from the cytosol, and tapasin, an ..
  81. ncbi ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
    Thomas Serwold
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    Nature 419:480-3. 2002
    ..Thus, ERAAP is the missing link between the products of cytosolic processing and the final peptides presented by MHC class I molecules on the cell surface...
  82. ncbi DC-SIGN: escape mechanism for pathogens
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology Vrije Universiteit Medical Center Amsterdam, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Nat Rev Immunol 3:697-709. 2003
    ..This implies that adaptation of pathogens to target DC-SIGN might support pathogen survival...
  83. ncbi Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum
    Loredana Saveanu
    Institut National de la Sante et Recherche Médicale Unité 580, Universite Rene Descartes Paris 5, 75015 Paris, France
    Nat Immunol 6:689-97. 2005
    ..required the concerted action of both ERAP1 and ERAP2, both for in vitro digestion and in vivo for cellular antigen presentation. ERAP1 and ERAP2 localized together in vivo and associated physically in complexes that were most likely ..
  84. doi TLR signalling regulated antigen presentation in dendritic cells
    Colin Watts
    Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Curr Opin Immunol 22:124-30. 2010
    ..These rapid changes require activation of the MAP kinases, PI3-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC...
  85. pmc Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
    Corrie A Painter
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 10655, USA
    Proc Natl Acad Sci U S A 108:19329-34. 2011
    ....
  86. doi CD169+ macrophages at the crossroads of antigen presentation
    Luisa Martinez-Pomares
    School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Trends Immunol 33:66-70. 2012
    ..Understanding the role of CD169(+) macrophages in the activation of acquired immunity could benefit the design of vaccination strategies, for example those aimed at eliciting cytotoxic T cells...
  87. pmc Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro
    Tirth R Ghimire
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom
    Immunol Lett 147:55-62. 2012
    ..Using a novel approach to tracking antigen and antigen presentation, we demonstrate that alum induces higher antigen accumulation and increased antigen presentation by ..
  88. pmc Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells
    Alexey V Tkach
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1686-90. 2013
    ..In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines...
  89. ncbi Altered antigen presentation in mice lacking H2-O
    M Liljedahl
    The R W Johnson Pharmaceutical Research Institute, San Diego, California 92121, USA
    Immunity 8:233-43. 1998
    ..Analysis of antigen presentation by B cells from mice lacking H2-O (the mouse equivalent of HLA-DO), together with biochemical analysis ..
  90. pmc Lentiviral vectors transduce proliferating dendritic cell precursors leading to persistent antigen presentation and immunization
    Frederick Arce
    Division of Infection and Immunity, University College London, London, UK
    Mol Ther 17:1643-50. 2009
    ..These results show that LVs transduce DC precursors, which maintain transduced DCs in spleen for at least 2 months, leading to prolonged antigen presentation and effective T-cell memory.
  91. doi Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells
    Ignacio Cebrian
    Institut Curie, INSERM U932, Immunité et Cancer, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Cell 147:1355-68. 2011
    ..Our findings provide insight into an intracellular traffic pathway required for crosspresentation and show that Sec22b-dependent recruitment of ER proteins to Phgs critically influences phagosomal functions in DCs...
  92. pmc A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation
    L Coscoy
    Howard Hughes Medical Institute and Departments of Microbiology and Medicine, University of California Medical Center, San Francisco, California 94143-0414, USA
    J Clin Invest 107:1599-606. 2001
    ..We propose that its expression reduces T cell responses to KSHV-infected B cells early in infection, thereby diminishing antiviral cytokine release and the production of stimulatory signals for CTL generation...
  93. pmc Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination
    Wolfgang Kastenmuller
    Institute of Molecular Virology, Antigen specific Immunotherapy Clinical Cooperation Group, National Research Center for Environment and Health, 81675 Munich, Germany
    J Exp Med 204:2187-98. 2007
    ..Our findings provide a basis for novel strategies for how boost vaccination to defined antigens can be selectively improved. They give important new insights into the design of more efficient poxviral vectors for immunotherapy...
  94. pmc A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression
    Xiao Tong Song
    Center for Cell and Gene Therapy, Baylor College of Medicine BCM, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Med 14:258-65. 2008
    ..Hence, this study identifies A20 as an antigen presentation attenuator in control of antitumor immune responses during both the priming and the effector phases and ..
  95. doi Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation
    Katrin Birkholz
    Department of Dermatology, University Hospital Erlangen, Hartmannstrasse 14, Erlangen, Germany
    Blood 116:2277-85. 2010
    ..We measured antigen presentation with specific autologous CD4(+) T cells, generated by TCR-RNA transfection...
  96. pmc DRiPs solidify: progress in understanding endogenous MHC class I antigen processing
    Jonathan W Yewdell
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Trends Immunol 32:548-58. 2011
    ..DRiPs enable the immune system to rapidly detect alterations in cellular gene expression with great sensitivity...
  97. ncbi Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses
    Ken C Pang
    T Cell Laboratory, Melbourne Centre for Clinical Sciences, Ludwig Institute for Cancer Research, Austin Health, Heidelberg, Victoria 3084, Australia
    J Immunol 177:7680-8. 2006
    ..Together, these results provide a clearer understanding of how immunodominance hierarchies are established...
  98. ncbi Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
    Tri Giang Phan
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Nat Immunol 8:992-1000. 2007
    ....
  99. pmc Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin
    James B McLachlan
    Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunity 30:277-88. 2009
    ..Therefore, balanced production of microbicidal and suppressive cytokines in inflamed skin is achieved by simultaneous dendritic cell antigen presentation to Teff and Treg cells.
  100. doi Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens
    Chun Hong Qiu
    RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    J Immunol 182:4127-36. 2009
    ..Transient ablation of this DC subset by cytochrome c injection resulted in a failure of tolerance induction to cell-associated Ags, indicating that this DC subset is essential for tolerance induction by apoptotic cell clearance...
  101. pmc Mycobacteria exploit p38 signaling to affect CD1 expression and lipid antigen presentation by human dendritic cells
    Maria Cristina Gagliardi
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Roma, Italy
    Infect Immun 77:4947-52. 2009
    ..In conclusion, we propose that p38 signaling is a novel pathway exploited by mycobacteria to affect the expression of CD1 antigen-presenting cells and avoid immune recognition...

Research Grants79

  1. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..the body for surveillance, and interact with T cells and dendritic cells within lymphoid tissue for antigen presentation. All these events are associated with dynamic morphological and compositional reorganization of the B cell ..
  2. DHAN V KALVAKOLANU; Fiscal Year: 2014
    ..form of death), which is critical for the removal of damaged organelle, fighting intracellular pathogens, antigen presentation and tumor suppression. Interestingly, the loss of C/EBP-2 gene in mice causes many of these defects...
  3. Roy Curtiss Iii; Fiscal Year: 2016
    ..secretion and/or by regulated delayed lysis in vivo with lysis occurring in cell compartments to enhance antigen presentation either by MHC Class I or Class II and by regulated delayed lysis in vivo in the cytoplasmic compartment to ..
  4. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ..a structural modularity, with which HEV recombinant capsid proteins interplay between VLP assembly and antigen presentation. By carrying insertion of 15 amino acids at an antibody-binding site, the chimeric VLP reduces the ..
  5. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..Cell-to-cell contact between an HIV-infected macrophage or DC and a T cell during antigen presentation can lead to infection of T cells by HIV-1, either by the secretion of newly- synthesized virus across the ..
  6. Richard J Samulski; Fiscal Year: 2014
    ..demonstrated that the AAV2 capsid can induce a cytotoxic T lymphocyte (CTL) response via both classical antigen presentation and cross-presentation pathways, thereby raising concerns associated with immune response to AAV vectors...
  7. Veena Taneja; Fiscal Year: 2014
    ..We hypothesize that antigen presentation by DQ8 molecule leads to production of high levels of pro- inflammatory IL-17 while polymorphism in DR4 ..
  8. Frances M Brodsky; Fiscal Year: 2014
    ..nutrient and cholesterol uptake, glucose transporter and insulin targeting, immune receptor traffic during antigen presentation and synaptic vesicle protein recapture...
  9. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..experiments will be performed with the following specific aims: Specific Aim 1: HIFU-enhanced tumor antigen presentation. To optimize the treatment parameters and determine the HIFU treatment sequence ("Low" Energy HIFU + "High" ..
  10. Michael D Cahalan; Fiscal Year: 2016
    ..immune system, STIM1 and Orai1 mediate antigen-induced Ca2+ signaling, motility inhibition at the site of antigen presentation, secretion of cytolytic granules by CD8+ T cells and NK cells, and gene expression responses that lead to ..
  11. Protective orthopox immunization in normals and patients with cancer or eczema
    Ellis Reinherz; Fiscal Year: 2009
    ..These advances include details of immune recognition at a structural level, antigen presentation, cell migration and T cell memory...
  12. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ..e., decreased T cell and macrophage (MO) antigen presentation function and increased lethality from subsequent sepsis, in young males;but not in proestrus females ..
  13. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012
    ..Our preliminary results suggest that phagosome maturation and consequent MHC-II antigen presentation are altered in DCs from a mouse model of the genetic disease, Hermansky-Pudlak syndrome (HPS) type 2 (HPS2)...
  14. Souheil El-Chemaly; Fiscal Year: 2014
    ..g. by promoting efficient inflammatory cell clearance) or detrimental (e.g. by promoting antigen presentation within draining lymph nodes and stimulating alloimmune responses)...
  15. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2013
    ..The genesis (antigen presentation and costimulation), priming (normal or defective), and quality (effector versus exhausted) of this ..
  16. Polymicrobial interactions in the lung.
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2010
    ..with Antigen Processing), which my recent preliminary studies reveal, suppresses influenza A virus antigen presentation by class I MHC molecules and the ability of cytotoxic T lymphocytes (CTL) to clear viral infections...
  17. Functional analysis of Phospholipase D4
    David Nemazee; Fiscal Year: 2010
    ..We hypothesize that PLD4 plays a role in antigen presentation through the regulation of endosomal function...
  18. Timothy W Schacker; Fiscal Year: 2014
    ..critical structures of the paracortical T cell zone (TZ) of secondary lymphatic tissues important for antigen presentation and T cell homeostasis...
  19. Chetan Seshadri; Fiscal Year: 2014
    ..He studied basic T-cell immunology at the NIH as a Howard Hughes Research Scholar and lipid antigen presentation by CD1 molecules as a research fellow at Harvard...
  20. Role of Surfactant in Innate and Adaptive Immunity
    Jo Rae Wright; Fiscal Year: 2010
    ..the roles of SP-A and SP-D and their receptors in regulating antigen uptake, intracellular targeting, and antigen presentation by bone marrow derived dendritic cells and mast cells...
  21. Antigen presentation by epithelial stem cells to promote life long immunity
    MARIE CLAIRE ELISABETH GAUDUIN; Fiscal Year: 2013
    ....
  22. Functional consequences of autophagy mutations in Crohn's disease.
    David L Boone; Fiscal Year: 2012
    ..Autophagy is also involved in the turnover of large proteins or protein complexes, cell death and antigen presentation. Innate immune signals regulate autophagy and conversely, autophagy can regulate the response of cells to ..
  23. Stephen D Miller; Fiscal Year: 2014
    ..Innate immune responses (expression of cytokines;chemokines;and antigen presentation molecules);and functional ability of CNS-derived DCs, MUs and microglia from TMEV-infected mice to activate ..
  24. Henry Daniell; Fiscal Year: 2016
    ..or mitigates pathogenic antibody responses (including anaphylaxis);to dissect the underlying mechanisms of antigen presentation and immune regulation;to find alternative transmucosal carriers for effective antigen delivery;to test the ..
  25. HCV in Alcoholics
    Jack R Wands; Fiscal Year: 2011
    ..us to characterize ethanol's effect on DCs with respect to cell surface markers, cytokine profiles, antigen presentation ability, and endocytosis capacity...
  26. Effects of Ethanol on Proteasome-HCV Core Protein Interactions
    NATALIA ALEKSANDR OSNA; Fiscal Year: 2010
    ..This enzyme degrades oxidatively modified proteins, signal transduction factors and processes peptides for antigen presentation. We hypothesize that HCV core protein enhances proteasome activity by directly interacting with the enzyme ..
  27. Polymicrobial Interactions in the Lung
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2013
    ..with Antigen Processing), which my recent preliminary studies reveal, suppresses influenza A virus antigen presentation by class I MHC molecules and the ability of cytotoxic T lymphocytes (CTL) to clear viral infections...
  28. The Contribution of Protein Methylation in Systemic Lupus Erythematosus
    Hester A Doyle; Fiscal Year: 2011
    ..We will determine how protein methylated self-antigens are processed for antigen presentation by digesting the known modified lupus autoantigens snRNP, histone H2B, and symmetrical dimethylarginine Sm ..
  29. KAREN TARASZKA HASTINGS; Fiscal Year: 2015
    ..of cutaneous autoimmunity to demonstrate the clinical significance and broad applicability of altered antigen presentation in Treg cell development...
  30. Modulation of T cell Homeostasis in Myelodysplastic Syndrome (MDS)
    Javier Pinilla; Fiscal Year: 2012
    ..to produce clinical responses in MDS and in cancer patients, appropriate antigen selection, intact antigen presentation, and T-cell function are all critical...
  31. MICHAEL VAN WILES; Fiscal Year: 2016
    ..receptor (FcRn) has four major functions: catabolic protection of IgG and albumin, transcytosis of IgG and antigen presentation. FcRn functions across many tissues and is critical for neonatal acquisition of maternal IgG via colostrum ..
  32. TRACY RUTH DANIELS-WELLS; Fiscal Year: 2014
    ..are expressed on key effector cells that are involved in the acute inflammatory response and antigen presentation. Moreover, the endogenous serum levels of IgE are very low in contrast to IgG...
  33. HS1 Function in Dendritic Cells
    Janis K Burkhardt; Fiscal Year: 2011
    ..HS1 is also expressed in dendritic cells, and our preliminary data show that HS1 is required for efficient antigen presentation. In addition, we find that HS1 is required for organization of podosomes, structures required for adhesion ..
  34. Structural Immunology of CD1 and CD1-TCR Complexes
    Dirk M Zajonc; Fiscal Year: 2013
    ..Structural insights into the differences of self vs. microbial antigen presentation will help understand the role of microbial lipids and lipid-reactive T cells in host defense and autoimmune ..
  35. Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice
    Veena Taneja; Fiscal Year: 2012
    ..However, the exact role of B cells in antigen presentation and their regulation in susceptible versus resistant strains of transgenic mice remains unclear...
  36. Nikon TiE Motorized Microscope System For 3D Image Acquisition, Deconvolution, Li
    Robert S Fuller; Fiscal Year: 2010
    ..have shown that one way this is accomplished is via the activity of the HIV- 1 Nef protein, which disrupts antigen presentation by altering the intracellular trafficking of MHC- I...
  37. PPAR-gamma-mediated neuroprotection against HIV-1 and alcohol CNS injury
    Yuri Persidsky; Fiscal Year: 2009
    ..We have previously shown that ethanol affects macrophage function (antigen presentation) and the blood brain barrier (BBS) by enhancing monocyte infiltration via disruption of tight junctions...
  38. Klaus F Ley; Fiscal Year: 2016
    ..Here, we propose to test which subsets are responsible for inflammatory cytokine production, antigen presentation, and foam cell formation, and how these processes are modulated by platelet factor 4 (Pf4, also known as ..
  39. Fatty Acid Binding Proteins in Macrophage Function
    Jill Suttles; Fiscal Year: 2013
    ..proinflammatory cytokines and are inefficient in the promotion of proinflammatory T cells responses during antigen presentation. FABP-deficient mice are protected from development of experimental autoimmune encephalomyelitis (EAE)...
  40. Transfusion Induced BMT Rejection
    James C Zimring; Fiscal Year: 2013
    ..Specific Aim 3: Analysis of Antigen Presentation Cells in Transfusion-Induced BMT Rejection...
  41. Host defense against influenza virus in the lungs of neonatal mice
    Beth A Garvy; Fiscal Year: 2010
    ..which have been attributed to an immature and naive immune system that is characterized by suboptimal antigen presentation and a T helper cell bias toward Th2-type cytokines...
  42. PATHOGENIC MECHANISMS OF CUTANEOUS LEISHMANIASIS
    Lynn Soong; Fiscal Year: 2012
    ....
  43. Judith M Phillips; Fiscal Year: 2016
    ..and functional assays to confirm tha JHM infection activates bone marrow-derived dendritic cells (DCs) for antigen presentation. Next, I will infect C57BL/6 mice adoptively transferred with lymphochoriomeningitis virus (LCMV) gp33 ..
  44. DANIELLE RENNER; Fiscal Year: 2014
    ..This proposal aims to address the hypothesis that enhancing effective antigen presentation and killer T cell recruitment into the CNS will result in the clearance of established gliomas...
  45. The role of complement system in alloimmune responses
    Qing Ma; Fiscal Year: 2013
    ..and lymphocytes: (1) C3 production by DCs is essential for their maturation, differentiation and effective antigen presentation to T cells;(2) Complement proteins also have an autocrine effect on APCs and T cells;(3) T cells also ..
  46. Chronic alcohol abuse disrupts CD8+T cell function
    Annette J Schlueter; Fiscal Year: 2013
    ..are affected by chronic ethanol;b) that these changes are irreversible;and c) that the defect is not one of antigen presentation in vivo...
  47. Modulation of Rab7-Dependent Degradative Pathways by Novel Adenovirus Protein
    Cathleen R Carlin; Fiscal Year: 2012
    ..regulation of cell surface receptor expression and signal transduction, maintenance of cell polarity, and antigen presentation. Many intracellular pathogens hijack endocytic pathways in order to invade cells, proliferate, and ensure ..
  48. Norovirus P Particle, A Multifunctional Platform For Vaccine Development
    Ming Tan; Fiscal Year: 2012
    ..This study will gather further evidence on the usefulness of the P particle platform for antigen presentation. The proposed research herein that base logically on our prior work combines the strengths of three labs of ..
  49. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan R Weiss; Fiscal Year: 2013
    ..compared with RA59 as far as spread of viral antigen into the cervical lymph nodes (CLN) and its impact on antigen presentation. These studies will add to the understanding of how closely related viruses may have very different ..
  50. Role of Elastolytic Cathepsins in Emphysema
    Harold A Chapman; Fiscal Year: 2010
    ..potent extracellular elastase stable at neutral pH and also a key endosomal acidic protease in MHC class II antigen presentation. Cathepsin S expression is higher in lungs of cigarette smokers and is induced in numerous cell types by ..
  51. CYTOKINE REGULATION IN EXPERIMENTAL ARTHRITIS
    Alison Finnegan; Fiscal Year: 2013
    ..These findings suggest that antigen presentation changes the early events in T cell polarization and that the innate microenvironment at these different ..
  52. Role of fascin1 in dendritic cell-mediated immunity against listeria infection
    Shigeko Yamashiro; Fiscal Year: 2013
    ..This resistance to Lm is thought to be crucial for the DCs primary function of antigen presentation: DCs must survive infection at the periphery and then move to draining lymph nodes for transferring antigen ..
  53. Astrid E Cardona; Fiscal Year: 2016
    ..The specific aims are: 1. to determine the role of CX3CR1 for the initiation of EAE via modulation of antigen presentation and T cell priming...
  54. Mapping the functional major histocompatibility complex genes in zebrafish
    JILL L DE JONG; Fiscal Year: 2012
    ..In addition, immunology experiments studying antigen presentation, activation of lymphocytes and natural killer cells, and infectious disease models in the zebrafish would ..
  55. KARIN L GAENSLER; Fiscal Year: 2014
    ..Previous efforts to improve antigen presentation of AML cells by in vitro differentiation into AML-derived dendritic cells were unsuccessful...
  56. Down-regulation of MHC class l molecules by HCMV US2
    Domenico Tortorella; Fiscal Year: 2009
    ..A full understanding of how HCMV US2 manipulates the cellular machinery of the host to prevent MHC class I and class II antigen presentation may permit the design of pharmaceutical agents that block US2 function.
  57. Role of IL-15 in CD8 T Cell Development and Response
    Leo Lefrancois; Fiscal Year: 2011
    ..that IL-15 andIL-15R play opposing roles in regulation of memory CD8 T cells responding to chronic antigen presentation. Aim 1...
  58. ASSEMBLY OF MHC CLASS I MOLECULES IN VITRO AND IN VIVO
    Hidde L Ploegh; Fiscal Year: 2012
    ..Combined, the proposed experiments will shed light on aspects of Class I MHC restricted antigen presentation that are poorly understood from a biochemical and cell biological perspective...
  59. GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2016
    ..that the achievement of such goals involves optimizing three distinct signals during vaccination, which are antigen presentation, co-stimulation and inflammation...
  60. Steven M Dubinett; Fiscal Year: 2016
    ..By altering the tumor microenvironment at the primary site, our investigations focus on restoring tumor antigen presentation and antitumor effector activities that can induce systemic antitumor immune responses and reduce metastatic ..
  61. HS1 Function in Dendritic Cells
    Deborah A Klos Dehring; Fiscal Year: 2010
    ..We have found that HS1 is required for efficient antigen presentation by DCs, specifically in receptor- mediated endocytosis of soluble antigen...
  62. Peripheral blood dendritic cells and periodontitis
    CHRISTOPHER WILLIAM CUTLER; Fiscal Year: 2012
    ..of microbes in the periphery, trafficking through the lymphatics to the secondary lymphoid organs, and antigen presentation to naive T cells...
  63. PEPTIDE BASED DELIVERY OF HIV IMMUNOGEN
    Lee Riley; Fiscal Year: 1999
    ..project using gp120 to study the efficiency of protein delivery, intracellular processing, and antigen presentation mediated by a 22-amino acid peptide derived from a surface protein of Mycobacterium tuberculosis...
  64. HEAT SHOCK PROTEIN GP96 AND IMMUNITY
    Nicholas Cohen; Fiscal Year: 2003
    This project addresses the hypothesis that gp96, a heat shock protein that has been implicated in antigen presentation in mammals, is part of an ancestral pathway that is antecedent to, and independent of, the antigen presentation pathway ..
  65. IRRITANTS EFFECTS ON EPIDERMAL ANTIGEN PRESENTATION
    Anthony Gaspari; Fiscal Year: 2002
    ..b>Antigen presentation by normal or irritant-treated epidermal KC or LC-like DC cells to skin homing T-lymphocyte populations will ..
  66. PEPTIDE-PULSED DENDRITIC CELL THERAPY FOR MELANOMA
    Frank Haluska; Fiscal Year: 2000
    ..cytokines that support the development of catalytic lymphocyte (CTL) responses, DCs are uniquely capable of antigen presentation. They appear to be ideal vehicles for delivery of antigen in tumor vaccination strategies...
  67. Innate Resistance to Mucosal HSV Infection in Humans
    Christine M Posavad; Fiscal Year: 2010
    ..have an effective innate immune response that results in an abortive infection and insufficient viral antigen presentation to generate a T cell response to HSV-2 ...
  68. ANTIGEN PRESENTATION BY CD1 MOLECULES
    Agustin Melian; Fiscal Year: 1999
    ..lesions from patients with mycobacterial infection correlates with resistance to disease, implies that antigen presentation by CD1 molecules may be playing a significant role in the host response against microbial infections...
  69. Development and evaluation of a novel SOCS1-silenced HIV vaccine
    Jerry Blackwell; Fiscal Year: 2009
    ..The relevance of such an improvement lies in the development and potential global impact of a vaccine that affords protection from HIV infection. ..
  70. Regulation of Antigen Presentation by APLP-2
    Joyce Solheim; Fiscal Year: 2005
    ..The long-range goal of our laboratory is to comprehend the regulation of antigen presentation by MHC class I molecules...
  71. REGULATION OF LANGERHANS CELL FUNCTION
    Richard Granstein; Fiscal Year: 1999
    The long-term goal of this application is to further understand the regulation of antigen presentation within the epidermis...
  72. INTRACELLULAR IA AND ANTIGEN PRESENTATION
    Jim Miller; Fiscal Year: 1999
    ..Third, the alternatively spliced p41 form of Ii is required for most Ii-dependent antigen presentation events...