autoimmunity

Summary

Summary: Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.

Top Publications

  1. doi CTLA-4 control over Foxp3+ regulatory T cell function
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:271-5. 2008
  2. ncbi The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    Arlene H Sharpe
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Immunol 8:239-45. 2007
  3. ncbi Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    Estelle Bettelli
    Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 441:235-8. 2006
  4. doi Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Nat Immunol 11:7-13. 2010
  5. doi Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
    Janet G M Markle
    Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Science 339:1084-8. 2013
  6. pmc IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
  7. pmc Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
    Xuyu Zhou
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:1983-91. 2008
  8. ncbi Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
  9. pmc 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A
    Sneha Joshi
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Mol Cell Biol 31:3653-69. 2011
  10. doi IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
    Markus F Neurath
    1st Medical Clinic, University of Erlangen Nurnberg, Germany
    Cytokine Growth Factor Rev 22:83-9. 2011

Detail Information

Publications398 found, 100 shown here

  1. doi CTLA-4 control over Foxp3+ regulatory T cell function
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:271-5. 2008
    ..Thus, natural Tregs may critically require CTLA-4 to suppress immune responses by affecting the potency of antigen-presenting cells to activate other T cells...
  2. ncbi The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    Arlene H Sharpe
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Immunol 8:239-45. 2007
    ..Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway...
  3. ncbi Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    Estelle Bettelli
    Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 441:235-8. 2006
    ..In contrast, CD4+CD25+Foxp3+ regulatory T (T(reg)) cells inhibit autoimmunity and protect against tissue injury...
  4. doi Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Nat Immunol 11:7-13. 2010
    ..anomalies or environmental agents that specifically or predominantly affect T(reg) cells cause or predispose to autoimmunity. With recent advances in our understanding of T(reg) cell development in the thymus and periphery and the ..
  5. doi Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
    Janet G M Markle
    Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Science 339:1084-8. 2013
    ..We demonstrate that early-life microbial exposures determine sex hormone levels and modify progression to autoimmunity in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D)...
  6. pmc IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
    ..Using passive transfer studies, we confirm that these IL-23-dependent CD4(+) T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity.
  7. pmc Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity
    Xuyu Zhou
    Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:1983-91. 2008
    ..These results support a central role for miRNAs in maintaining the stability of differentiated T reg cell function in vivo and homeostasis of the adaptive immune system...
  8. ncbi Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
    ..We used aire- deficient mice to test the hypothesis that this transcription factor regulates autoimmunity by promoting the ectopic expression of peripheral tissue- restricted antigens in medullary epithelial cells of ..
  9. pmc 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A
    Sneha Joshi
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Mol Cell Biol 31:3653-69. 2011
    ..Our results describe novel mechanisms and new concepts with regard to vitamin D and the immune system and suggest therapeutic targets for the control of autoimmune diseases...
  10. doi IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
    Markus F Neurath
    1st Medical Clinic, University of Erlangen Nurnberg, Germany
    Cytokine Growth Factor Rev 22:83-9. 2011
    ..In this review article, we discuss the latest findings on the role of IL-6 in experimental models of autoimmunity and cancer, as well as clinical perspectives.
  11. pmc The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 104:17040-5. 2007
    Type 1 diabetes (T1D) results from progressive loss of pancreatic islet mass through autoimmunity targeted at a diverse, yet limited, series of molecules that are expressed in the pancreatic beta cell...
  12. pmc Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions
    Ayumi Yoshizaki
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 491:264-8. 2012
    ..The ex vivo expansion and reinfusion of autologous B10 cells may provide a novel and effective in vivo treatment for severe autoimmune diseases that are resistant to current therapies...
  13. pmc Autoimmune T cell responses in the central nervous system
    Joan Goverman
    Department of Immunology, University of Washington, Seattle, Washington 98195 7650, USA
    Nat Rev Immunol 9:393-407. 2009
    ..Recent data indicate that CNS autoimmunity can be mediated by two distinct lineages of CD4+ T cells that are defined by the production of either ..
  14. doi TLR-dependent T cell activation in autoimmunity
    Kingston H G Mills
    Immunology Research Centre and School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Nat Rev Immunol 11:807-22. 2011
    ..This leads to pro-inflammatory cytokine production and T cell activation, which are now considered to be major factors in the development of autoimmunity.
  15. pmc The PD-1 pathway in tolerance and autoimmunity
    Loise M Francisco
    Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunol Rev 236:219-42. 2010
    ..Elimination of either can result in the breakdown of tolerance and the development of autoimmunity. The PD-1: PD-L pathway can thwart self-reactive T cells and protect against autoimmunity in many ways...
  16. pmc Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 234:142-62. 2010
    ..Furthermore, while activated pDCs promote immunity and autoimmunity, resting or alternatively activated pDCs may be tolerogenic...
  17. doi MicroRNAs in autoimmunity and inflammatory bowel disease: crucial regulators in immune response
    Marisa Iborra
    Fundacion Hospital Universitari La Fe, Department of Gastroenterology, Hospital Universitari La Fe, Valencia, Spain
    Autoimmun Rev 11:305-14. 2012
    ..Furthermore, it is possible that some miRNAs are specific to IBD and could serve as biomarkers with clinical applications for the diagnosis or assessment of disease activity...
  18. doi IL-23: one cytokine in control of autoimmunity
    Andrew L Croxford
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Eur J Immunol 42:2263-73. 2012
    ..its pathogenic role has been mostly scrutinized in the context of Th17 cells, which were thought to mediate autoimmunity by secretion of IL-17 family cytokines...
  19. pmc Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand
    Laura A Solt
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA
    Nature 472:491-4. 2011
    ....
  20. doi Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity
    Takumi Kawasaki
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Immunol Rev 243:61-73. 2011
    ..In this review, we discuss the roles of nucleic acid-sensing receptors in guarding against pathogen invasion, discriminating between self and non-self, and contributing to autoimmunity and autoinflammatory diseases.
  21. pmc A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand
    Avijit Ray
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Immunol 188:3188-98. 2012
    ..Because Treg suppress autoimmune responses, we asked whether B cells control autoimmunity by maintenance of Treg numbers...
  22. pmc miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
    Mark P Boldin
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Med 208:1189-201. 2011
    ..Collectively, our findings suggest that miR-146a plays a key role as a molecular brake on inflammation, myeloid cell proliferation, and oncogenic transformation...
  23. ncbi Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    Prapaporn Pisitkun
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases NIAID, NIH, Rockville, MD 20852, USA
    Science 312:1669-72. 2006
    Antibodies against nuclear self-antigens are characteristic of systemic autoimmunity, although mechanisms promoting their generation and selection are unclear...
  24. doi Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    Caroline E Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Immunity 31:331-41. 2009
    ..Our findings demonstrate that gammadelta T cells activated by IL-1beta and IL-23 are an important source of innate IL-17 and IL-21 and provide an alternative mechanism whereby IL-1 and IL-23 may mediate autoimmune inflammation...
  25. ncbi B cells regulate autoimmunity by provision of IL-10
    Simon Fillatreau
    University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
    Nat Immunol 3:944-50. 2002
    ..In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover. These data show that B cell-derived IL-10 plays a key role in controlling autoimmunity.
  26. doi The role of defective clearance of apoptotic cells in systemic autoimmunity
    Luis E Munoz
    Department of Internal Medicine, Erlangen University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Nat Rev Rheumatol 6:280-9. 2010
    ..defect that can cause the permanent presence of cellular debris responsible for the initiation of systemic autoimmunity in diseases such as systemic lupus erythematosus (SLE)...
  27. pmc Cytokine-producing B lymphocytes-key regulators of immunity
    Frances E Lund
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Curr Opin Immunol 20:332-8. 2008
    ....
  28. ncbi Multiple sclerosis: a complicated picture of autoimmunity
    Henry F McFarland
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:913-9. 2007
    ..Careful analysis of the alterations in immune processes should further advance knowledge of the relationship between the inflammatory component of this disease and the more diffuse degeneration of progressive multiple sclerosis...
  29. doi Autoimmune disease and gender: plausible mechanisms for the female predominance of autoimmunity
    Olga L Quintero
    Center for Autoimmune Diseases Research CREA, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia
    J Autoimmun 38:J109-19. 2012
    ..These hormonal changes as well as the genetic factors that could explain why women are more prone to develop ADs are herein reviewed...
  30. pmc FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
    Manuela Fanciulli
    Physiological Genomics and Medicine Group, UK Medical Research Council MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nat Genet 39:721-3. 2007
    ..Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity.
  31. ncbi Interleukin-21: basic biology and implications for cancer and autoimmunity
    Rosanne Spolski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1674, USA
    Annu Rev Immunol 26:57-79. 2008
    ..The key to harnessing the power of IL-21 will depend on better understanding its range of biological actions, its mechanism of action, and the molecular basis of regulation of expression of IL-21 and its receptor...
  32. pmc Toll-like receptor driven B cell activation in the induction of systemic autoimmunity
    Nathaniel M Green
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    Semin Immunol 23:106-12. 2011
    ..Further understanding of the role of specific receptors, cell subsets, and inhibitory signals that govern these TLR-associated pathways will enable future therapeutics to be tailored to specific categories of autoimmune disease...
  33. pmc Follicular helper T cells are required for systemic autoimmunity
    Michelle A Linterman
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Exp Med 206:561-76. 2009
    ..We postulated a positive selection defect in GCs to account for autoantibodies. We first demonstrate that autoimmunity in Roquin(san/san) (sanroque) mice is GC dependent: deletion of one allele of Bcl6 specifically reduces the ..
  34. doi Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease
    M Schwartz
    The Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Psychiatry 15:342-54. 2010
    ..Accordingly, the brain's 'privilege' is its acquisition of a private peripheral immunological niche under its own control, which supports brain function. Immune malfunction may comprise a missing link between a healthy and diseased mind...
  35. pmc Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    Alevtina Gall
    Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
    Immunity 36:120-31. 2012
    ..These findings reveal a stepwise progression of autoimmune disease in Trex1-deficient mice, with implications for the treatment of AGS and related disorders...
  36. doi Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice
    Jean Claude Souberbielle
    Laboratoire de Physiologie, CHU Necker, Paris, France
    Autoimmun Rev 9:709-15. 2010
    ..In addition, where data were limited to smaller clinical trials or epidemiologic studies, the panel made expert-opinion based recommendations...
  37. pmc Self-targeting by CRISPR: gene regulation or autoimmunity?
    Adi Stern
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Trends Genet 26:335-40. 2010
    ..with abundance of degraded repeats near self-targeting spacers, suggests that self-targeting is a form of autoimmunity rather than a regulatory mechanism...
  38. pmc Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity
    Diane L Kamen
    Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
    J Mol Med (Berl) 88:441-50. 2010
    ..The purpose of this manuscript is to review the molecular and clinical evidence for vitamin D as a modulator of the innate and adaptive immune system...
  39. pmc Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines
    Kai Kisand
    Molecular Pathology Group, Institute of General and Molecular Pathology, University of Tartu, 50411 Tartu, Estonia
    J Exp Med 207:299-308. 2010
    ..The autoantibodies preceded the CMC in all informative cases. We conclude that IL-22 and IL-17F are key natural defenders against CMC and that the immunodeficiency underlying CMC in both patient groups has an autoimmune basis...
  40. ncbi A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    Carola G Vinuesa
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Nature 435:452-8. 2005
    ..The Roquin protein is distinguished by the presence of a CCCH zinc-finger found in RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating messenger RNA translation and stability...
  41. doi Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    Nicholas Simpson
    Australian National University, Canberra, ACT, Australia
    Arthritis Rheum 62:234-44. 2010
    ..The purpose of this study was to examine the hypothesis that this pathway could account for a subset of patients with systemic lupus erythematosus (SLE)...
  42. ncbi Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    Jeong M Kim
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 8:191-7. 2007
    ..We suggest that self-reactive T cells are continuously suppressed by T(reg) cells and that when suppression is relieved, self-reactive T cells become activated and facilitate accelerated maturation of dendritic cells...
  43. pmc How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets
    Markus Feuerer
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 31:654-64. 2009
    ..Thus, Treg cells regulate pancreatic autoimmunity in situ through control of a central innate immune system player, NK cells.
  44. doi B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer
    David J DiLillo
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 1183:38-57. 2010
    ..Remarkably, B10 cells are potent negative regulators of inflammation and autoimmunity in mouse models of disease in vivo...
  45. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  46. ncbi beta-Cell death during progression to diabetes
    D Mathis
    Section on Immunology and Immunogenetics, Joslin Diabetes Centre, One Joslin Place, Boston, Massachusetts 02215, USA
    Nature 414:792-8. 2001
    ..beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes...
  47. pmc Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity
    Elizabeth R Walsh
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 109:16276-81. 2012
    ..7 (Tlr7) has been linked to systemic lupus disease incidence in humans and mice, but how TLR7 potentiates autoimmunity is unclear...
  48. pmc A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
    E S Huseby
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    J Exp Med 194:669-76. 2001
    ..Here, we demonstrate that myelin-specific CD8(+) T cells induce severe CNS autoimmunity in mice...
  49. pmc Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity
    Mauritius Menges
    Department of Dermatology, University of Erlangen, Erlangen 91052, Germany
    J Exp Med 195:15-21. 2002
    ..In conclusion, this study describes that stimulation by TNF-alpha results in incompletely matured DCs (semi-mature DCs) which induce peptide-specific IL-10-producing T cells in vivo and prevent EAE...
  50. doi Precipitating and perpetuating factors of rheumatoid arthritis immunopathology: linking the triad of genetic predisposition, environmental risk factors and autoimmunity to disease pathogenesis
    I C Scott
    Department of Rheumatology, Guy s Hospital, Great Maze Pond, London, UK
    Best Pract Res Clin Rheumatol 25:447-68. 2011
    ..outlining the specific gene-environment and gene-gene interactions that may occur to precipitate and perpetuate autoimmunity and RA...
  51. pmc The epigenetics of autoimmunity
    Francesca Meda
    Department of Medicine and Hepatobiliary Immunopathology Unit, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Cell Mol Immunol 8:226-36. 2011
    ..support other complementary mechanisms involved in the regulation of genes expression ultimately causing overt autoimmunity. Alterations in the post-translational modification of histones and DNA methylation are the two major ..
  52. doi The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells
    Huai Chia Chuang
    Immunology Research Center, National Health Research Institutes, Zhunan, Taiwan
    Nat Immunol 12:1113-8. 2011
    ..Thus, GLK is a direct activator of PKC-θ, and activation of GLK-PKC-θ-IKK could be used as new diagnostic biomarkers and therapeutic targets for systemic lupus erythematosus...
  53. doi Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
    Brian T Fife
    Department of Medicine, UCSF Diabetes Center, University of California, San Francisco, CA 94113, USA
    Immunol Rev 224:166-82. 2008
    ....
  54. doi Hydroxychloroquine: from malaria to autoimmunity
    Ilan Ben-Zvi
    Rheumatology Unit, Zabludowicz Center for Autoimmune Diseases and Department of Internal Medicine F, Sheba Medical Center, Tel Hashomer, Israel
    Clin Rev Allergy Immunol 42:145-53. 2012
    ..In this review, we discuss the known various immunomodulatory mechanisms of antimalarials and the current evidence for their beneficial effects in various diseases and in potential novel applications...
  55. ncbi How TCRs bind MHCs, peptides, and coreceptors
    Markus G Rudolph
    Department of Molecular Structural Biology, University of Gottingen, 37077 Gottingen, Germany
    Annu Rev Immunol 24:419-66. 2006
    ..Notwithstanding, the impressive array of self, foreign (microbial), and autoimmune TCR complexes have uncovered the diverse ways in which antigens can be specifically recognized by TCRs...
  56. pmc Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    Peter Attia
    Surgery Branch, National Cancer Institute, National Institutes of Health, CRC, Room 3W 3940, 10 Center Dr, Bethesda, MD 20892 1201, USA
    J Clin Oncol 23:6043-53. 2005
    ..We have now treated 56 patients to evaluate two different dose schedules of anti-CTLA-4 and to explore the relationship between autoimmunity and tumor regression.
  57. pmc Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
    Ira Surolia
    Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 466:243-7. 2010
    ..9 in subjects with type I diabetes. Functionally defective SIAE rare and polymorphic variants represent a strong genetic link to susceptibility in relatively common human autoimmune disorders...
  58. doi Th17 cells in immunity and autoimmunity
    M Oukka
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Rheum Dis 67:iii26-9. 2008
    ....
  59. pmc Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity
    Santhakumar Manicassamy
    Emory Vaccine Center, and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA
    Nat Med 15:401-9. 2009
    ..These data define a new mechanism for the systemic induction of retinoic acid and immune suppression against autoimmunity.
  60. pmc The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity
    Rita M Tavares
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Immunity 33:181-91. 2010
    ..These findings show that A20 can restrict B cell survival, whereas A20 protects other cells from TNF-induced cell death. Our studies demonstrate how reduced A20 expression predisposes to autoimmunity.
  61. doi Oxidative stress in Egyptian children with autism: relation to autoimmunity
    Gehan A Mostafa
    Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    J Neuroimmunol 219:114-8. 2010
    ..F2-isoprostane, as a marker of lipid peroxidation, and glutathione peroxidase, as an antioxidant enzyme) and autoimmunity (as indicated by serum antineuronal antibodies) in a group of 44 Egyptian autistic children and 44 healthy ..
  62. doi Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis
    Hiba Mahdi
    Rheumatology Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
    Nat Genet 41:1319-24. 2009
    ..Here, we test the hypothesis that a subset of the anti-CCP response, with specific autoimmunity to citrullinated alpha-enolase, accounts for an important portion of these associations...
  63. pmc Defining the role of the MHC in autoimmunity: a review and pooled analysis
    Michelle M A Fernando
    Section of Molecular Genetics and Rheumatology, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS Genet 4:e1000024. 2008
    ..Furthermore, we find a number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity.
  64. doi Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss?
    Adriano Fontana
    Institute of Experimental Immunology, University Hospital Zurich, Haeldeliweg 4, CH 8044 Zurich, Switzerland
    Brain 133:1300-11. 2010
    ..Activation of microglia and macrophages may lead to the release of neurotoxic molecules such as quinolinic acid, which has been shown to cause selective destruction of hypocretin neurons in the hypothalamus...
  65. doi Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    Marco Prinz
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    Immunity 28:675-86. 2008
    The action of type I interferons in the central nervous system (CNS) during autoimmunity is largely unknown...
  66. doi Cracking the BAFF code
    Fabienne Mackay
    Department of Immunology, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Nat Rev Immunol 9:491-502. 2009
    ..In this Review, we consider the possibility that in mice autoimmunity induced by BAFF is linked to T cell-independent B cell activation rather than to a severe breakdown of B cell ..
  67. doi Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells
    Natalie A Carter
    Division of Medicine, Centre for Rheumatology Research, University College London, London W1T 4JF, United Kingdom
    J Immunol 186:5569-79. 2011
    IL-10-producing B cells, also known as regulatory B cells (Bregs), play a key role in controlling autoimmunity. In this study, we report that chimeric mice specifically lacking IL-10-producing B cells (IL-10(-/-)B cell) developed an ..
  68. pmc The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games
    Thomas Hehlgans
    Institute of Medical Microbiology, University of Dusseldorf, Germany
    Immunology 115:1-20. 2005
    ..Molecular and cellular mechanisms that demonstrate a therapeutic potential by targeting individual receptors or ligands for the treatment of chronic inflammatory or autoimmune diseases are discussed...
  69. doi The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Nature 453:106-9. 2008
    ..AHR ligands may therefore represent co-factors in the development of autoimmune diseases...
  70. pmc Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity
    Caspar Ohnmacht
    Institute for Immunology, Department of Medicine, University of Munich, 80336 Munich, Germany
    J Exp Med 206:549-59. 2009
    Lack of immunological tolerance against self-antigens results in autoimmune disorders. During onset of autoimmunity, dendritic cells (DCs) are thought to be critical for priming of self-reactive T cells that have escaped tolerance ..
  71. doi Role of microRNA-155 in autoimmunity
    Rui Xue Leng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China
    Cytokine Growth Factor Rev 22:141-7. 2011
    ..Since pathogenic immune cells play a pivotal role in pathogenesis of human autoimmune diseases, miR-155 might be a versatile therapeutic target. This review will discuss the current understandings for the role of miR-155 in autoimmunity.
  72. pmc Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity
    Yanick J Crow
    Academic Unit of Medical Genetics, Manchester Academic Health Science Centre, Central Manchester Foundation Trust, St Mary s Hospital, University of Manchester, Oxford Road, Manchester M13 9WL, UK
    Hum Mol Genet 18:R130-6. 2009
    ..These studies provide important insights into the pathogenesis of SLE and beg urgent questions about the development and use of immunosuppressive therapies in AGS and related phenotypes...
  73. ncbi Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity
    A Stofkova
    Department of Normal, Pathological, and Clinical Physiology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Endocr Regul 43:157-68. 2009
    ..This review discusses the main biological activities of leptin and adiponectin as well as their contribution to inflammatory and autoimmune processes with particular focus on rheumatoid arthritis and its experimental models...
  74. ncbi Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity
    Ilia J Elenkov
    Division of Rheumatology, Immunology and Allergy, Georgetown University Medical Center, Washington, DC 20007, USA
    Ann N Y Acad Sci 966:290-303. 2002
    ....
  75. pmc Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
    ..Bcl2l11(-/-)Fas(lpr/lpr) mice developed remarkably enhanced and accelerated fatal lymphadenopathy and autoimmunity compared to mice lacking only one of these apoptosis inducers...
  76. pmc Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome
    Joanna Groom
    The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, NSW, Australia
    J Clin Invest 109:59-68. 2002
    ..We conclude that altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis...
  77. ncbi T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
    Vijay K Kuchroo
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 20:101-23. 2002
    ..which activation with foreign antigens can result in the generation of pathogenic memory T cells that mediate autoimmunity. We also outline circumstances under which activation of self-reactive T cells with foreign antigens can ..
  78. pmc Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    Thomas Korn
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 13:423-31. 2007
    ..However, the dynamics and function of T-reg in autoimmunity are not well understood. Thus, we developed Foxp3gfp knock-in (Foxp3gfp...
  79. ncbi Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes
    Nicole A Sherry
    Section of Immunobiology, Yale University, 300 Cedar St, Room S155B, New Haven, CT 06520, USA
    Diabetes 55:3238-45. 2006
    ..Correction of the beta-cell loss in type 1 diabetes will, therefore, require strategies that target both the immunologic and cellular mechanisms that destroy and maintain beta-cell mass...
  80. ncbi IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    Matthew A Burchill
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 178:280-90. 2007
    IL-2(-/-) mice develop autoimmunity despite having relatively normal numbers of regulatory T cells (Tregs). In contrast, we demonstrate that IL-2(-/-) x IL-15(-/-) and IL-2Rbeta(-/-) mice have a significant decrease in Treg numbers...
  81. doi Effects of tobacco smoke on immunity, inflammation and autoimmunity
    Yoav Arnson
    Department of Medicine D, Meir Medical Center, Kfar Saba, Israel
    J Autoimmun 34:J258-65. 2010
    ..The current review underlines the importance of smoking prevention and eradication not only in respiratory disorders but also in autoimmune conditions as well...
  82. pmc A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
    Srividya Subramanian
    Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 103:9970-5. 2006
    ....
  83. pmc Follicular helper T cells in immunity and systemic autoimmunity
    Joseph E Craft
    Department of Internal Medicine, Yale University School of Medicine, PO Box 208031, 300 Cedar Street, New Haven, CT 06520 8031, USA
    Nat Rev Rheumatol 8:337-47. 2012
    ..As such, our understanding of the genesis of T(FH) cells in humans and their role in the development of autoimmunity remains incomplete...
  84. ncbi Microglial cell activation and proliferation precedes the onset of CNS autoimmunity
    Eugene D Ponomarev
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53201 2178, USA
    J Neurosci Res 81:374-89. 2005
    ....
  85. ncbi CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    Thomas R Malek
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA
    Immunity 17:167-78. 2002
    Lethal autoimmunity associated with IL-2Rbeta-deficient mice is prevented after thymic transgenic expression of wild-type IL-2Rbeta in IL-2Rbeta(-/-) mice (Tg -/- mice)...
  86. pmc Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation
    A Jager
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Scand J Immunol 72:173-84. 2010
    ..and Th9 cells, and regulatory T cells, like Tregs and Tr1 cells, has changed the way we view and understand autoimmunity at cellular and molecular levels...
  87. ncbi A blast from the past: clearance of apoptotic cells regulates immune responses
    John Savill
    MRC University of Edinburgh Centre for Inflammation Research, Department of Clinical and Surgical Sciences Internal Medicine, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK
    Nat Rev Immunol 2:965-75. 2002
    ..Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future...
  88. pmc Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    Mark E Dudley
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20902, USA
    Science 298:850-4. 2002
    ..This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases...
  89. doi Immune cell crosstalk in type 1 diabetes
    Agnes Lehuen
    Institut National de la Santé et de la Recherche Médicale INSERM U986, Hopital Saint Vincent de Paul, Bâtiment Petit, 82 avenue Denfert Rochereau, 75014 Paris, France
    Nat Rev Immunol 10:501-13. 2010
    ..cell populations and T cells have highlighted how these different cell populations can influence the onset of autoimmunity. There is evidence that infection can have either a potentiating or inhibitory role in the development of type ..
  90. pmc TLR8 deficiency leads to autoimmunity in mice
    Olivier Demaria
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    J Clin Invest 120:3651-62. 2010
    ..These data provide evidence for a pivotal role for mouse TLR8 in the regulation of mouse TLR7 expression and prevention of spontaneous autoimmunity.
  91. pmc Antiviral immune responses: triggers of or triggered by autoimmunity?
    CHRISTIAN MUNZ
    Viral Immunobiology, Institute of Experimental Immunology, University Hospital Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Immunol 9:246-58. 2009
    ..Among these environmental factors, infections have been implicated in the onset and/or promotion of autoimmunity. In this Review, we outline the mechanisms by which viral infection can trigger autoimmune disease and describe ..
  92. pmc CD40 and autoimmunity: the dark side of a great activator
    Anna L Peters
    Immunology Graduate Program and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Semin Immunol 21:293-300. 2009
    ..This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40:CD154 interactions as an autoimmune ..
  93. pmc MicroRNA in autoimmunity and autoimmune diseases
    Kaleb M Pauley
    Department of Oral Surgery and Diagnostic Sciences, University of Florida, Gainesville, FL 32610 0424, USA
    J Autoimmun 32:189-94. 2009
    ..demonstrated that miRNAs play a vital role in the regulation of immunological functions and the prevention of autoimmunity. Here we review the many newly discovered roles of miRNA regulation in immune functions and in the development ..
  94. pmc IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
    Ivan D Mascanfroni
    1 Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA 2
    Nat Immunol 14:1054-63. 2013
    ..Finally, therapeutic vaccination with IL-27-conditioned DCs suppressed established relapsing-remitting EAE. Thus, IL-27 signaling in DCs limited pathogenic T cell responses and the development of autoimmunity.
  95. doi SERPINB3, apoptosis and autoimmunity
    Laura Vidalino
    Clinica Medica 5, Department of Clinical and Experimental Medicine, University of Padua, Italy
    Autoimmun Rev 9:108-12. 2009
    ..Since defective programmed cell death represents a critical feature of autoimmunity, the involvement of SERPINB3 in this pathological field deserves further studies.
  96. pmc Triggers and drivers of autoimmunity: lessons from coeliac disease
    Ludvig M Sollid
    Centre for Immune Regulation and the Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, N 0372 Oslo, Norway
    Nat Rev Immunol 13:294-302. 2013
    ..These observations challenge the notion that autoimmunity requires adaptive immune activation towards self antigens...
  97. doi The role of miRNA in inflammation and autoimmunity
    Ram Pyare Singh
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA Electronic address
    Autoimmun Rev 12:1160-5. 2013
    ..We believe that understanding the role of miRNAs could shed light on the cause and progression of many inflammatory and autoimmune diseases and eventually lay the groundwork for therapeutic options. ..
  98. pmc The role of dendritic cells in autoimmunity
    Dipyaman Ganguly
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA
    Nat Rev Immunol 13:566-77. 2013
    ..However, fundamental questions remain unanswered concerning the actual roles of DCs in autoimmunity, both in general and, in particular, in specific diseases...
  99. pmc A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models
    Xuezhi Dai
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
    J Clin Invest 123:2024-36. 2013
    ..germinal center, and age-related B cell expansion as well as the development of autoantibodies and systemic autoimmunity. Further, PEP-R619W affected B cell selection and B lineage-restricted variant expression and was sufficient to ..
  100. pmc Genetic and hormonal factors in female-biased autoimmunity
    Anatoly V Rubtsov
    Howard Hughes Medical Institute and Department of Immunology, National Jewish Health and University of Colorado Health Sciences Center, Denver, 80206, USA
    Autoimmun Rev 9:494-8. 2010
    b>Autoimmunity is controlled both by the environment and by genetic factors...
  101. pmc WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
    Shirly Becker-Herman
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA Seattle Children s Research Institute, Seattle, WA, USA
    J Exp Med 208:2033-42. 2011
    Patients with the immunodeficiency Wiskott-Aldrich syndrome (WAS) frequently develop systemic autoimmunity. Here, we demonstrate that mutation of the WAS gene results in B cells that are hyperresponsive to B cell receptor and Toll-like ..

Research Grants67

  1. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..Mgat5 deficient 129/Sv mice develop late onset spontaneous kidney autoimmunity and are more susceptible to experimental autoimmune encephalomyelitis (EAE), an animal model of MS...
  2. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2013
    ..deficient mice have shown that Cbl-b is critical in T cell activation, and loss of Cbl-b results in increased autoimmunity. Cbl-b functions as RING-type E3 ubiquitin ligase to promote ubiquitin conjugation to critical signaling ..
  3. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..2) We previously found autoimmunity to the 11(V) collagen chain to predispose patients to obliterative bronchiolitis(OB), the fibroproliferative ..
  4. Cellular &Molecular Defects in Human B Cell Development
    Charlotte Cunningham-Rundles; Fiscal Year: 2013
    ..especially in heterozygous form are significantly more likely to develop striking lymphoid hyperplasia and autoimmunity. Using human B cells and transfectants with TACI mutations, we will investigate TACI receptor function in ..
  5. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..as unique patient registries, repositories and core technologies provide a solid foundation for the Oklahoma Autoimmunity Center of Excellence (ACE) application to which we have added a multidisciplinary team of clinical and basic ..
  6. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    ..The proposed novel translational and analytic approaches can lead to methodological advances in the field of autoimmunity and can address a significant knowledge gap in SSc clinical care and clinical trial design...
  7. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    ..of BOS the first goal of this application is to test the hypothesis that down regulation of pre-existing autoimmunity to self-Ags prior to LTx will abrogate interactions between pre-existing Abs to self-Ags and their determinants ..
  8. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..and hematin, a leucine-zipper (bZip) transcription factor, a regulator of TNF-1- activated kinase-mediator of autoimmunity and activator of NF-:B...
  9. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..Although these findings support a role for VD3 in autoimmunity, its mechanism(s) is largely unknown...
  10. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    ..However, abnormal TLR activation can modulate human immunodeficiency or autoimmunity. My overall hypothesis is that abnormal innate and adaptive immune responses resulting from the disease-..
  11. Interdisciplinary Research Training in Reproduction for Indian Fellows
    John C Herr; Fiscal Year: 2010
    ..neuroendocrine control of mechanisms in reproduction, molecular control of spermatogenesis and oogenesis, autoimmunity to sperm antigens;sperm maturation in the epididymis, and circadian rhythms...
  12. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..an initial step in the path to predicting how n-3 PUFA consumption might prevent or ameliorate acceleration of autoimmunity by silica and other toxicants...
  13. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..a key component of cardiovascular diseases and related pathophysiological processes, including atherosclerosis, autoimmunity, allograft rejection, the diabetes-metabolic syndrome, hemostasis and thrombosis, and wound healing...
  14. Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    Clifford A Lowell; Fiscal Year: 2013
    ..As a result, SHP-1 deficient animals (motheaten (me/me) or motheaten viable (mev/mev)) develop dramatic autoimmunity, inflammation and early mortality due to lung inflammation (~4 weeks for complete SHP-1 loss in me/me mice and ~..
  15. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..The major theme of the Stanford Autoimmunity Center of Excellence (the Center) is the study of the regulation of CD4 T cells in pathogenesis and treatment ..
  16. Molecular Mechanism of Immune Therapy for Bone Marrow Failures
    Pearlie K Epling-Burnette; Fiscal Year: 2013
    ..In the Progress Report, our data strongly suggests that a multi-step model of autoimmunity for this disease process based on work during the last funding period...
  17. Epigenetic downregulation of the antibody response and inhibition of autoimmunity
    Paolo Casali; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Epigenetic downregulation of the antibody response and inhibition of autoimmunity Epigenetic marks (including histone modifications, DNA methylation and microRNAs) "interact" with genetic programs to ..
  18. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..CHB, a pathologic readout of passively acquired autoimmunity, provides an exceptional opportunity to examine the effector arm of immunity and define the mechanism whereby ..
  19. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..In this application we will test the central hypothesis that elastin-specific autoimmunity characterized by the presence of activated T helper subsets, is linked to the pathological and physiological ..
  20. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..Interestingly, characterization of YYAA mice has led me to a new research interest --autoimmunity and immune tolerance...
  21. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    ..Until now the population in whom to address this essential clue to autoimmunity, children with autoimmune disease who are progressing through puberty, has not been available in sufficient ..
  22. Regulation of Chronic Colitis by Mesenchymal Stem Cells
    Matthew B Grisham; Fiscal Year: 2013
    ..addition, recent investigations show that the immunosuppressive activity of MSCs in different mouse models of autoimmunity is not restricted to the major histocompatibility complex suggesting that MSCs are "immune-privileged"...
  23. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2012
    ..be in a position to (1) determine the role of CD5 in the development of B1a B-cells and its contribution to autoimmunity, (2) elucidate how CD5 regulates B-cell responses to T-independent antigens and T-dependent antigens and (3) ..
  24. Impact of smoking on immune response and arthritis in humanized mice
    Veena Taneja; Fiscal Year: 2011
    ..Clinical studies have suggested that ACPA precede onset of clinical symptoms of RA suggesting autoimmunity starts much earlier that the actual onset of clinical disease...
  25. Gene Transcription in SLE
    George C Tsokos; Fiscal Year: 2012
    ..completion will introduce additional mechanisms that lead to the generation of autoantigens that drive autoimmunity. PUBLIC HEALTH RELEVANCE - PROJECT NARRATIVE: Systemic lupus erythematosus (SLE) afflicts more than one million ..
  26. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..of B cells and T cells with effector functions (to protect against pathogens) and regulatory functions to avoid autoimmunity. The overarching theme of this competitive renewal of the University of Rochester Autoimmunity Center of ..
  27. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..autoantibody formation in mouse models of arthritis and the definition of the relative roles of IL-17-driven autoimmunity and inflammation would both suggest novel therapeutic targets for arthritis and other autoimmune diseases and ..
  28. Yale Autoimmunity Center of Excellence
    Kevan C Herold; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We propose to establish an Autoimmunity Center of Excellence at Yale University that will serve the southern New England region...
  29. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..Our strategy is to selectively target voltage-gated Kv1.3 potassium channels in effector memory T cells that are important mediators of autoimmune diseases. ..
  30. A XENOPUS LAEVIS RESEARCH RESOURCE FOR IMMUNOBIOLOGY
    Jacques Robert; Fiscal Year: 2013
    ..expression of class I and other adult-specific antigens allows one to address questions about MHC restriction, autoimmunity, and the development of self-tolerance that can not be easily studied in other animal models. Studies with X...
  31. CNS Demyelinating Autoimmunity Targeting Water Channel Complexes
    SEAN JOSEPH PITTOCK; Fiscal Year: 2013
    ..as the potential basis of NMO in apparently seronegative patients. Knowledge of the frequency of AQP4 autoimmunity, correlation with ethnicity and frequency of MS misdiagnosis will impact health care delivery and economics...
  32. The molecular mechanism of Aire: partnering with DNA-PK
    Diane J Mathis; Fiscal Year: 2013
    ..Mutation of the locus encoding murine Aire also resulted in multi-organ autoimmunity. Studies on this model revealed Aire to operate primarily within a rare population of thymic stromal cells by ..
  33. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
    ..auto antibodies and TSHR T cell epitopes in mice and possibly also into the pathogenesis of human thyroid autoimmunity. 3. Induced tolerance to prevent or treat experimental Graves'disease...
  34. Autoimmunity in the Mediation of Infectious Myocarditis
    Jay Reddy; Fiscal Year: 2013
    ..patients show antibodies to coxsackievirus B3 (CVB) and cardiac antigens, suggesting a role for CVB-mediated autoimmunity in the disease pathogenesis, but a direct causal link remains to be determined clinically...
  35. The Role of Sex in Self Antigen Generation in SLE
    David Stephen Pisetsky; Fiscal Year: 2010
    ..including the expression of fetal Y chromosome DNA in the blood of pregnant mice to determine the impact of autoimmunity on the generation and clearance of DNA from the blood...
  36. The relative roled of sex and genes during development of systemic autoimmunity
    TRINE NORGAARD JORGENSEN; Fiscal Year: 2010
    ..This is particularly evident in Sjvgren's Syndrome, systemic lupus erythromatosis (SLE) and thyroid autoimmunity, where the ratio of females to males ranges from 20:1 to 8:1...
  37. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
    ..Persistent NF-kB activation may lead to pathologic consequences such as chronic inflammation, autoimmunity or malignancy...
  38. HLA-D Region in Systemic Lupus Erythematosus Pathogenesis
    Shu Man Fu; Fiscal Year: 2013
    ..Our hypothesis states that lupus susceptibility genes exert their effect on either autoimmunity or resistance to end organ damage...
  39. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic 04-AR-101 Autoimmunity for Diseases of Skin, Joints, Muscles and Other Tissues...
  40. Autoimmunity Against Novel Antigens in Neuropsychiatric Dysfunction
    Josep O Dalmau; Fiscal Year: 2013
    ....
  41. Ligands and cofactors required for RORgt function in the immune system
    Dan Littman; Fiscal Year: 2013
    ..Th17 cells have recently been shown to be major mediators of disease in several models for autoimmunity in the mouse, and there is accumulating evidence that they have similar roles in humans...
  42. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    ..such comparisons are expected to yield critical insights into sex-based differences in normal immunity and autoimmunity. An attractive hypothesis is that differences in sex hormone levels or signaling through their receptors shift ..
  43. Rapid Analysis of Single T Cell Immunity Signatures in Tuberculosis
    Sanjay Tyagi; Fiscal Year: 2013
    ..and disease staging of any pathology with T cell involvement, including other infectious diseases, cancer, autoimmunity, and transplantation...
  44. A Systems Biology Approach for Pediatric and Adult Autoimmune Diseases
    MARIA VIRGINIA PASCUAL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We propose to create an Autoimmunity Center of Excellence that will incorporate the efforts of clinicians, human immunologists (both basic and translational), physician-scientists with clinical ..
  45. SEX EFFECTS ON CHEMOKINE MEDIATED CNS AUTOIMMUNITY
    Lillian Cruz-Orengo; Fiscal Year: 2012
    ..receptor, S1PR2, might be a more specific target for manipulation of BBB biology during brain and spinal cord autoimmunity. In addition, our data reveals that white matter expression of this receptor exhibits sexual dimorphism, which ..
  46. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2013
    ..It is hoped that the results of this study will allow safer application of this curative therapy to a greater number of patients and aid in improving tolerogenic therapy for autoimmunity and solid organ transplantation as well.
  47. Synaptic autoimmunity in disorders of memory, behavior, cognition and psychosis
    Josep Dalmau; Fiscal Year: 2010
    ....
  48. Identification of stromal responses during castration-induced thymic regrowth.
    Howard T Petrie; Fiscal Year: 2013
    ..to infectious disease, decreased response to vaccines, decreased anti-tumor surveillance, increased autoimmunity, and other related disorders...
  49. Mechanisms of Peripheral Induction of T-Cell Tolerance
    MATTHEW FRANKLIN MESCHER; Fiscal Year: 2013
    ..in vivo Project Leader: Marc Jenkins DESCRIPTION (provided by applicant): Most people do not suffer from autoimmunity despite the production of CD4+ T cells expressing T cell receptors (TCR) specific for self peptide (p):major ..
  50. Viral suppression of CNS autoimmunity
    Stephen A Stohlman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Autoimmunity is an attack on the host carried out by its own immune system. Genetic and environmental agents, i.e...
  51. Role of ABCG1 in lipid homeostasis, inflammation and innate immunity
    ELIZABETH JOANNA TARLING; Fiscal Year: 2013
    ..Inflammation is a hallmark characteristic of diseases such as atherosclerosis, autoimmunity, obesity and cancer. Inflammation is a stereotypical response of the innate (inborn) immune system to pathogens...
  52. Inflammation and T Lymphocyte Immunoregulation
    Ann B Hill; Fiscal Year: 2013
    ..vaccine design, immune evasion by viruses or bacteria, tumor immunology, immunopathology, transplantation, and autoimmunity benefit from learning about methods of investigation and advances in the other areas as part of this ..
  53. The Role of CRACM1 in the Pathogenesis of Systemic Lupus Erythematosus
    Peter C Chien; Fiscal Year: 2013
    ..residency in at NYU School of Medicine and is currently a research fellow in the Training Program in Autoimmunity at Beth Israel Deaconess Medical Center (BIDMC)...
  54. AUTOIMMUNITY CENTER OF EXCELLENCE
    David Wofsy; Fiscal Year: 2013
    ..Project 1 - Genetically-Engineered Antigen-Specific Treqs to Treat Autoimmunity (Jeffrey Bluestone, PI): The principal goals of this project are: (i) to develop engineered antigen-specific ..
  55. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    ..e. hepatitis C virus), but also in other T cell-mediated pathological conditions such as autoimmunity, graft rejection or cancer...
  56. Targeting Sirtuin-1 to enhance Foxp3+ regulatory T-cell function
    Ulf Beier; Fiscal Year: 2013
    ..Therefore, our central hypothesis is that targeting Sirt1 may have therapeutic value in autoimmunity and transplantation...
  57. MECHANISMS OF AUTOIMMUNITY IN SLE
    David Stephen Pisetsky; Fiscal Year: 2013
    ..Successful completion of these experiments will provide new insights in the pathogenic role in SLE of nuclear molecules in the form of microparticles as well as provide new biomarkers and potential targets of therapy. ..
  58. Suppression of Collagen Induced Arthritis with Altered Peptide Ligands
    Andrew H Kang; Fiscal Year: 2010
    ..We have used the animal model of CIA to develop a specific immunotherapy capable of selectively blocking autoimmunity without interfering with the beneficial functions of the immune system...
  59. Antibody Mediated Autoimmunity in Neuromyelitis Optica
    HANS CHRISTIAN VON BUEDINGEN; Fiscal Year: 2013
    ..Thus, NMO can be considered a model disease for CNS directed B cell and antibody autoimmunity. AQP4 is a water channel protein, which is expressed in astrocytes of the CNS...
  60. T CELL RESPONSE TO MYELIN PROTEOLIPID PROTEIN
    Vijay K Kuchroo; Fiscal Year: 2013
    ..by the innate immune system dictate the balance between pathogenic/regulatory T cells and the development of autoimmunity. In addition to IL-6, we have now observed that IL-4 can also suppress induction of Fox-P3 and together with ..
  61. The Effects of C-Reactive Protein on Autoimmunity
    Terry W Du Clos; Fiscal Year: 2013
    ..Therefore, understanding the role this protein plays in the risk for SLE will aid in understanding the cause and treatment of this and other autoimmune diseases in Veterans. ..
  62. The role of neutrophil extracellular traps and NADPH oxidase in SLE pathogenesis
    ALLISON MARIE CAMPBELL; Fiscal Year: 2012
    ..Our mechanistic studies into the role of NADPH oxidase in autoimmunity will not only provide insight into the predisposition to SLE that has been noted in patients with CGD, but will ..
  63. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..First, progenitor strains of recombinant inbred mice which do and do not develop peptide induced autoimmunity will be ascertained...
  64. MECHANISMS OF ALLOGENEIC STEM CELL EDUCATION IN SCID
    Rebecca H Buckley; Fiscal Year: 2010
    ..telomere length in the T cells of the various molecular types of transplants, 3) reducing the incidence of autoimmunity, and 4) contributing to their overall successful immune transplantation may be beneficial to these chimeras by ..
  65. Immune Tolerance and Autoimmunity
    Abul K Abbas; Fiscal Year: 2010
    The objectives of this PPG are to understand what controls the choice between tolerance and autoimmunity. Using established experimental models, the component projects will explore the molecular pathways and genetic modifiers of central ..
  66. Recurrence of T1D in Pancreas Transplantation
    George Burke; Fiscal Year: 2009
    ..The observed frequency of autoimmunity in association with increased risk of hyperglycemia is higher than previously reported in smaller and earlier ..
  67. The 5th International Leukocyte Signal Transduction Workshop
    Amnon Altman; Fiscal Year: 2009
    ..Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by the genetic manipulation of mice, which led to significant insights ..