antigen antibody reactions


Top Publications

  1. ncbi Application of impedance spectroscopy for monitoring colloid Au-enhanced antibody immobilization and antibody-antigen reactions
    Meijia Wang
    College of Chemistry, Jilin University, Changchun 130021, PR China
    Biosens Bioelectron 19:575-82. 2004
  2. ncbi Human monoclonal antibody against Hepatitis B virus surface antigen (HBsAg)
    Yong Won Shin
    Antibody Engineering Laboratory, Research Center, Green Cross Corporation, 341 Bojeong dong, Giheung gu, Yongin City, Gyunggi do 446 799, Republic of Korea
    Antiviral Res 75:113-20. 2007
  3. ncbi Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes
    Salit Tzaban
    Department of Molecular Biology, The Hebrew University Hadassah Medical School, and Hadassah University Hospital, Jerusalem 91120, Israel
    Biochemistry 41:12868-75. 2002
  4. ncbi Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance
    Mitchell R Smith
    Lymphoma Service, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Oncogene 22:7359-68. 2003
  5. ncbi Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis
    C T Ravirajan
    Department of Medicine, University College London, GB
    Eur J Immunol 28:339-50. 1998
  6. ncbi Mechanisms of transfusion-related acute lung injury (TRALI): anti-leukocyte antibodies
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI, USA
    Crit Care Med 34:S118-23. 2006
  7. ncbi Biosensor immunosurface engineering inspired by B-cell membrane-bound antibodies: modeling and analysis of multivalent antigen capture by immobilized antibodies
    Yanan Zheng
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    IEEE Trans Nanobioscience 2:14-25. 2003
  8. ncbi Isolation of human anti-idiotypes broadly cross reactive with anti-dsDNA antibodies from patients with Systemic lupus erythematosus
    W Zhang
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA
    Scand J Immunol 53:192-7. 2001
  9. ncbi [Specific and nonspecific interactions of antibodies and immunoglobulins with antigens and the methods of analysis of these interactions]
    S A Bobrovnik
    Ukr Biokhim Zh 76:132-9. 2004
  10. ncbi Differential interactions of phytochrome A (Pr vs. Pfr) with monoclonal antibodies probed by a surface plasmon resonance technique
    Chihoko Natori
    Hitachi Advanced Research Laboratory, Hatoyama, Saitama 350 0395, Japan
    Photochem Photobiol Sci 6:83-9. 2007

Detail Information

Publications229 found, 100 shown here

  1. ncbi Application of impedance spectroscopy for monitoring colloid Au-enhanced antibody immobilization and antibody-antigen reactions
    Meijia Wang
    College of Chemistry, Jilin University, Changchun 130021, PR China
    Biosens Bioelectron 19:575-82. 2004
    ..The results show that this method has good correlation for detection of Hepatitis B virus surface antigen in the range of 0.5-200 microg/l and a detection limit of about 50 ng/l...
  2. ncbi Human monoclonal antibody against Hepatitis B virus surface antigen (HBsAg)
    Yong Won Shin
    Antibody Engineering Laboratory, Research Center, Green Cross Corporation, 341 Bojeong dong, Giheung gu, Yongin City, Gyunggi do 446 799, Republic of Korea
    Antiviral Res 75:113-20. 2007
    ..The HB-C7A binds to HBV-infected human liver tissue but does not bind to normal human tissues. This HB-C7A has several advantages compared to plasma-derived Hepabig such as activity, safety and availability...
  3. ncbi Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes
    Salit Tzaban
    Department of Molecular Biology, The Hebrew University Hadassah Medical School, and Hadassah University Hospital, Jerusalem 91120, Israel
    Biochemistry 41:12868-75. 2002
    ..Whether these new PrP(Sc) species play a role in the biogenesis or the pathogenesis of prions remains to be established...
  4. ncbi Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance
    Mitchell R Smith
    Lymphoma Service, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Oncogene 22:7359-68. 2003
    ..As the first of an expanding class of anticancer agents, lessons learned regarding the mechanism of rituximab action and resistance will be of increasing importance...
  5. ncbi Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis
    C T Ravirajan
    Department of Medicine, University College London, GB
    Eur J Immunol 28:339-50. 1998
    ..In this study we have shown for the first time using electron microscopy that a human IgG anti-dsDNA mAb, RH-14, is nephritogenic and that deposition of such an antibody alone is sufficient to induce renal damage...
  6. ncbi Mechanisms of transfusion-related acute lung injury (TRALI): anti-leukocyte antibodies
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI, USA
    Crit Care Med 34:S118-23. 2006
    ..Genotyping for class I and II HLA and for a limited number of neutrophil antigens may also be helpful in establishing antibody-antigen concordance...
  7. ncbi Biosensor immunosurface engineering inspired by B-cell membrane-bound antibodies: modeling and analysis of multivalent antigen capture by immobilized antibodies
    Yanan Zheng
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    IEEE Trans Nanobioscience 2:14-25. 2003
    ..An analysis of the derived model provides insight into the design of biosensor immunosurfaces to enhance pathogen capture capability...
  8. ncbi Isolation of human anti-idiotypes broadly cross reactive with anti-dsDNA antibodies from patients with Systemic lupus erythematosus
    W Zhang
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA
    Scand J Immunol 53:192-7. 2001
    ..Such anti-idiotypic antibodies could play a significant role in the regulation of anti-dsDNA antibody levels in SLE...
  9. ncbi [Specific and nonspecific interactions of antibodies and immunoglobulins with antigens and the methods of analysis of these interactions]
    S A Bobrovnik
    Ukr Biokhim Zh 76:132-9. 2004
    ..The methods of the diminishing the non-specific interaction are suggested...
  10. ncbi Differential interactions of phytochrome A (Pr vs. Pfr) with monoclonal antibodies probed by a surface plasmon resonance technique
    Chihoko Natori
    Hitachi Advanced Research Laboratory, Hatoyama, Saitama 350 0395, Japan
    Photochem Photobiol Sci 6:83-9. 2007
  11. ncbi Outer membrane protein-specific monoclonal antibodies protect SCID mice from fatal infection by the obligate intracellular bacterial pathogen Ehrlichia chaffeensis
    J S Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 166:1855-62. 2001
  12. ncbi Immunoglobulin M efficacy against Cryptococcus neoformans: mechanism, dose dependence, and prozone-like effects in passive protection experiments
    C P Taborda
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 166:2100-7. 2001
  13. ncbi Investigating specific antigen/antibody binding with the atomic force microscope
    O Ouerghi
    Laboratoire de Physique des Interfaces, Faculté des Science de Monastir, Monastir, Tunisia
    Biomol Eng 19:183-8. 2002
    ..The analysis using the height histograms reveals many interesting features. We propose a general framework for interpreting these analysis, which enables the discrimination between specific and non-specific complexes...
  14. ncbi Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody
    Roberto De Pascalis
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:3076-84. 2002
    ..The final variant of the HuCOL-1, which retains its Ag-binding reactivity and shows significantly lower serum reactivity than that of the parental Ab, can serve as a prototype for the development of a potentially useful clinical reagent...
  15. ncbi Structural basis for recognition of CD20 by therapeutic antibody Rituximab
    Jiamu Du
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 282:15073-80. 2007
    ..These results provide a molecular basis for the specific recognition of CD20 by Rituximab as well as valuable information for development of improved antibody drugs with better specificity and higher affinity...
  16. ncbi Detection of 2,4,6-trinitrotoluene in seawater using a reversed-displacement immunosensor
    Tiffanee M Green
    Center for Bio Molecular Science and Engineering, US Naval Research Laboratory, CBMSE Code 6900, 4555 Overlook Ave SW, Washington, DC 20375 5320, USA
    Anal Biochem 310:36-41. 2002
  17. ncbi Production of monoclonal antibodies for detection of a secreted aspartyl proteinase from Candida spp. in biologic specimens
    Janaina Aparecida De Oliveira Rodrigues
    Area de Microbiologia e Imunologia, Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, UNICAMP, SP, Brazil
    Hybridoma (Larchmt) 26:201-10. 2007
    ..albicans and C. dubliniensis extracts. The results herein obtained allow for the prediction of how this set of antibodies can be useful for SAP detection in biologic specimens...
  18. ncbi Antibody nanoarrays with a pitch of approximately 20 nanometers
    Yu He
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    J Am Chem Soc 128:12664-5. 2006
    ..In the resulting tetragonal antibody arrays, each spot is a similarly orientated, individual antibody molecule (IgG). The separation between two adjacent IgG molecules is only approximately 20 nm...
  19. ncbi Stereoselective recognition of monolayers of cholesterol, ent-cholesterol, and epicholesterol by an antibody
    M Geva
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, 76100 Israel
    Chembiochem 2:265-71. 2001
    ..The lack of chiral discrimination by the antibody is thus correlated to the level at which the chirality is exposed at the surface of the monolayers...
  20. ncbi Hemagglutinin linear epitope presentation on monolayer-protected clusters elicits strong antibody binding
    Aren E Gerdon
    Department of Chemistry, Vanderbilt University, VU Station B, Nashville, Tennessee 37235 1822, USA
    Biomacromolecules 6:3419-24. 2005
    ..Water-soluble nanoparticles that present known neutralizing peptide epitopes of protein antigens might be used in antiviral influenza vaccines...
  21. ncbi Specificity of antibodies: unexpected cross-reactivity of antibodies directed against the excitatory amino acid transporter 3 (EAAT3)
    S Holmseth
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, P O Box 1105, Blindern, N 0317 Oslo, Norway
    Neuroscience 136:649-60. 2005
    ..The specificity of an antibody is hard to predict because cross-reactivity can be specific and to unrelated molecules. The antigen preabsorption test is of little value in testing the specificity of affinity purified antibodies...
  22. ncbi Epitope mapping of the protective antigen of B. anthracis by using nanoclusters presenting conformational peptide epitopes
    Aren E Gerdon
    Department of Chemistry, Vanderbilt University, Station B 351822, Nashville, TN 37235, USA
    Angew Chem Int Ed Engl 45:594-8. 2006
  23. ncbi [Dissection of specificity and affinity of an antibody for its specific antigen]
    Kouhei Tsumoto
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan
    Seikagaku 78:93-109. 2006
  24. ncbi Characterization of an anti-MUC1 monoclonal antibody with potential as a cancer vaccine
    W Qi
    AltaRex Corp, Edmonton, AB, Canada
    Hybrid Hybridomics 20:313-24. 2001
    ..5, but not in mice treated with control murine antibody or PBS (p < 0.001 and p < 0.05, respectively). An anti-tumor effect could also be demonstrated in a CB6F1 mouse model with the MUC1 transfectoma 413BCR...
  25. ncbi Oxidation of beta2-glycoprotein I (beta2GPI) by the hydroxyl radical alters phospholipid binding and modulates recognition by anti-beta2GPI autoantibodies
    J Arvieux
    Laboratoire d Immunologie, Institut de Synergie des Sciences et de la Sante, CHU Brest, France
    Thromb Haemost 86:1070-6. 2001
    ..These findings may be of clinical relevance for the generation and/or reactivity of anti-beta2GPI antibodies...
  26. ncbi A novel tumor-associated mucin of gastrointestinal carcinoma
    K M Hong
    Department of Biochemistry, Wonkwang University College of Medicine, Iksan, Korea
    J Cancer Res Clin Oncol 127:551-8. 2001
    ..Therefore, SC142 may become a valuable tool for the immunohistochemical diagnosis and tumor immunoscintigraphy of the gastrointestinal cancer patients...
  27. pmc Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies
    Kausik Chakraborty
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India
    Biochem J 399:483-91. 2006
    ..The data suggest that because of the low accessibility of the V3 loop on primary isolates such as JRFL, it will be difficult to elicit a V3-specific, 447-52D-like antibody response to effectively neutralize such isolates...
  28. ncbi Analysis of the binding of bispecific monoclonal antibodies with immobilized antigens (human IgG and horseradish peroxidase) using a resonant mirror biosensor
    Dmitriy A Dmitriev
    Division of Chemical Enzymology, Department of Chemistry, Moscow State University, Moscow, Russian Federation
    J Immunol Methods 261:103-18. 2002
    ..On the other hand, these data demonstrate that real-time analysis of antibody binding parameters in IAsys biosensor is valuable for the selection of mAbs and bAbs with desired features, for different fields of application...
  29. ncbi Generation of a humanised single chain Fv (Scfv) derived from the monoclonal Eric-1 recognising the human neural cell adhesion molecule
    H A Whittington
    Division of Oncology, University of Bristol, United Kingdom
    Med Pediatr Oncol 36:243-6. 2001
    ..CONCLUSIONS: The humanised scFv may prove to be a useful reagents in the treatment and diagnosis of a variety of neuroectodermal tumours and can clearly form a suitable template for the generation of a fully humanised ERIC-1 MoAb...
  30. ncbi Section 1A: Rh serology. Coordinator's report
    M Scott
    International Blood Group Reference Laboratory, Southmead Road, Bristol, BS10 5ND, UK
    Transfus Clin Biol 9:23-9. 2002
    ..No patterns of reactivity corresponding to the epitope groups could be observed with the different types of weak D tested. Anti-E Mabs were sorted into 14 groups, and the E variant cells into seven groups...
  31. ncbi Mutations of an epitope hot-spot residue alter rate limiting steps of antigen-antibody protein-protein associations
    Y Li
    Basic Research Laboratory, Program in Structural Biology, National Cancer Institute, Frederick Cancer Research and Development Center, P.O. Box B, Building 469, Room 206, Frederick, Maryland 21702-1201, USA
    Biochemistry 40:2011-22. 2001
    ..Our results are consistent with the interpretation that the free energy barriers to conformational rearrangement are highest in H26, especially with mutant antigen...
  32. ncbi Production of anti-digoxigenin antibody HRP conjugate for PCR-ELISA DIG detection system
    Pooria Gill
    Department of Medical Biotechnology, Tarbiat Modarres University, Tehran, Iran
    J Immunoassay Immunochem 27:303-18. 2006
    ..Several biochemical protocols and modifications were applied to increase the sensitivity and specificity of this conjugate for an efficient and cost-effective product...
  33. ncbi Preparation and characterization of anti-anti-idiotypic monoclonal antibody ("Ab1-like Ab3") in relation to carcinoembryonic antigen
    Masayuki Tsujisaki
    Department of Internal Medicine Section 1, Sapporo Medical University, School of Medicine, Sapporo, Japan
    J Clin Lab Anal 16:279-89. 2002
    ..These results indicate that anti-anti-Id MoAb 11B2 is "Ab1-like Ab3." Therefore, it is suggested that anti-Id MoAb M315 bears an "internal image" of the MoAb P1-356-defined epitope on CEA...
  34. pmc Combinatorial experimental protocols for Erbicin-derived immunoagents and Herceptin
    C De Lorenzo
    Dipartimento di Biologia Strutturale e Funzionale, Universita di Napoli Federico II, Via Cinthia, Napoli 80126, Italy
    Br J Cancer 97:1354-60. 2007
  35. ncbi Identification of the epitope of a monoclonal antibody to DJ-1
    David W Miller
    Laboratory of Neurogenetics, National Institute on Aging, Bldg 35, Rm 1A 1002, 35 Convent Drive, Bethesda, MD 20892, USA
    Neurosci Lett 374:203-6. 2005
    ..Moreover, the loss of immunoreactivity due to such a small substitution demonstrates the remarkable sensitivity of the monoclonal antibody 3E8 to DJ-1...
  36. ncbi Expression and functional activity of isotype and subclass switched human monoclonal antibody reactive with the base of the V3 loop of HIV-1 gp120
    Fangbing Liu
    Beth Israel Deaconess Medical Center, Massachusetts 02215, USA
    AIDS Res Hum Retroviruses 19:597-607. 2003
  37. pmc Interaction between the antigen and antibody is controlled by the constant domains: normal mode dynamics of the HEL-HyHEL-10 complex
    Masaaki Adachi
    School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Protein Sci 12:2125-31. 2003
    ..UL2-CL could play an important role and could be attractive for modification in protein engineering...
  38. ncbi Serological studies of monoclonal RH antibodies with RH1 (D), RH2 (C), RH3 (E) and RH5 (e) variant RBCs
    F Noizat-Pirenne
    Etablissement Français du Sang, Site Henri Mondor, 56, avenue du Maréchal de Lattre de Tasssigny, 94010 Creteil, France
    Transfus Clin Biol 10:319-23. 2003
    ..Therefore, we drew parallels between our procedures and results obtained with the 2001 workshop antibodies...
  39. pmc Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin
    D A Schafer
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    J Cell Biol 126:403-12. 1994
  40. ncbi Studies on experimental iodine allergy: 1. Antigen recognition of guinea pig anti-iodine antibody
    Hiroshi Shionoya
    Department of Drug Safety Research, Eisai Kawashima Research Laboratories, Eisai Co, Ltd, 1 Takehaya cho, Kawashima cho, Hashima gun, Gifu 501 0061, Japan
    J Toxicol Sci 29:131-6. 2004
  41. ncbi Screening for epitope specificity directly on culture supernatants in the early phase of monoclonal antibody production by an ELISA with biotin-labeled antigen
    Ditte C Andersen
    Department of Immunology and Microbiology, University of Southern Denmark, Odense C, Denmark
    J Immunoassay Immunochem 25:147-57. 2004
    ..Moreover, the bonus effect, i.e., a signal in excess of the reference signal when sets of monoclonal antibodies with different epitope specificity are compared, gives a relative measure of affinity...
  42. ncbi A new approach for fluorescence correlation spectroscopy (FCS) based immunoassays
    Oleg A Mayboroda
    Department of Parasitology, Leiden University Medical Centre LUMC, The Netherlands
    J Biotechnol 107:185-92. 2004
    ..We have evaluated the feasibility of this approach in a model system consisting of mouse monoclonal IgG directed against the Lewis X antigen, and Protein A as a low molecular weight tag...
  43. ncbi Studies with Synthetic Peptides of 80 kDa Human Sperm Antigen (80 kDa HSA)
    Vandana J Vernekar
    National Institute for Research, in Reproductive Health, J M Street, Parel, Mumbai, India
    Am J Reprod Immunol 51:106-11. 2004
    ..These sequenced peptides were synthesized and conjugated to key hole limpet haemocyanin (KLH) and evaluated for its antifertility effects. The present communication describes the characterization of these peptides and their antibodies...
  44. ncbi Characterization of a single-chain intrabody directed against the human receptor tyrosine kinase Ron
    Paola Secco
    Department of Medical Sciences and Interdisciplinary Research Center of Autoimmune Diseases IRCAD, University of Eastern Piedmont A Avogadro, Via Solaroli 17, 28100 Novara, Italy
    J Immunol Methods 285:99-109. 2004
    ..We demonstrate that the isolated antibody fragment interacts in vivo with the intracellular domain of Ron in mammalian cells...
  45. ncbi Polyreactivity of antibody molecules
    Abner Louis Notkins
    Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research NIH, Bethesda, MD 20892 4322, USA
    Trends Immunol 25:174-9. 2004
  46. ncbi Quantification of the major allergen from cypress (Cupressus arizonica) pollen, Cup a 1, by monoclonal antibody-based ELISA
    M C Arilla
    Research and Development Department, Bial Aristegui, Bilbao, Spain
    Int Arch Allergy Immunol 134:10-6. 2004
    ..The aim of this study is to develop a sandwich ELISA for the quantification of Cup a 1, the major allergen of cypress (Cupressus arizonica) pollen extract...
  47. ncbi Determination of the binding parameters for a pre-existing antigen-antibody mixture
    S A Bobrovnik
    Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv
    Ukr Biokhim Zh 75:107-14. 2003
    ..Such a method could be useful for characterization of infection and autoimmune processes when the antigen and antibodies circulate together in the bloodstream...
  48. ncbi Antibody therapy for Alzheimer's disease
    Dave Morgan
    Dept of Pharmacology, University of South Florida, Tampa, FC 33612 4799, USA
    Expert Rev Vaccines 2:53-9. 2003
    ..This review summarizes the rationale, progress and setbacks regarding the use of antibody-based therapies to treat Alzheimer's disease and discusses future directions for this approach in Alzheimer's and other disorders...
  49. ncbi Antibody multispecificity mediated by conformational diversity
    Leo C James
    Centre for Protein Engineering, Medical Research Council Centre, Hills Road, Cambridge CB2 2HQ, UK
    Science 299:1362-7. 2003
    ..Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy...
  50. ncbi Monoclonal antibodies as a probe for the unfolding of porcine growth hormone
    Vitaliano Borromeo
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Biochimica e Fisiologia Veterinaria, University of Milan, Via Celoria 10, Italy
    J Immunol Methods 272:107-15. 2003
    ..e. immunoblotting and immunohistochemistry; 3) the performances of the other eight mAbs differed significantly in the competitive and non-competitive ELISA...
  51. ncbi A hypoallergenic vaccine obtained by tail-to-head restructuring of timothy grass pollen profilin, Phl p 12, for the treatment of cross-sensitization to profilin
    Kerstin Westritschnig
    Christian Doppler Laboratory for Allergy Research, Division of Immunopathology, Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Immunol 179:7624-34. 2007
    ..The strategy of tail-to-head reassembly of hypoallergenic allergen fragments within one molecule represents a generally applicable strategy for the generation of allergy vaccines...
  52. ncbi Four different clones of mouse anti-acetyllysine monoclonal antibodies having different recognition properties share a common immunoglobulin framework structure
    Yasuhiko Komatsu
    CREST Research Project, Japan Science and Technology Corporation, Kawaguchi Center Building, 4 1 8 Hon cho, Saitama 332 0012, Japan
    J Immunol Methods 272:161-75. 2003
  53. pmc Use of monoclonal antibodies that recognize p60 for identification of Listeria monocytogenes
    Kang Y Yu
    KOMED Institute for Life Science, Graduate School of Biotechnology, Korea University, Rm 640, 1, 5 Ka, Anam Dong, Sungbuk Ku, Seoul 136 701, Korea
    Clin Diagn Lab Immunol 11:446-51. 2004
    ..Appl. Environ. Microbiol. 60:3120-3127, 1997). To our best knowledge, this is the first example of an immunological identification system that uses p60-recognizing MAbs...
  54. ncbi On molecular recognition of an uranyl chelate by monoclonal antibodies
    Jean Marie Teulon
    CEA VALRHO, DSV iBEB SBTN, BP 17171, 30207 Bagnols sur Ceze, France
    J Mol Recognit 20:508-15. 2007
    ..In addition, the unbinding process goes through two steps; the first weakens the bonding of the central metal with AspL50 of the antibody and the second breaks other non-bonded interactions of the compound with the antibody...
  55. pmc Critical contribution of VH-VL interaction to reshaping of an antibody: the case of humanization of anti-lysozyme antibody, HyHEL-10
    Takeshi Nakanishi
    Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai 980 8579, Japan
    Protein Sci 17:261-70. 2008
  56. ncbi A direct antigen-binding assay for detection of antibodies against native epitopes using alkaline phosphatase-tagged proteins
    Konstantin Baranov
    Laboratory of Immunogenetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Lavrentyev ave 10, Novosibirsk 630090, Russia
    J Immunol Methods 332:73-81. 2008
    ..The results obtained show that AP-tagged proteins are useful tools for discrimination of antibodies against native epitopes when production of antigen in its native conformation is laborious and expensive...
  57. ncbi A rapid and efficient strategy to generate antigen-specific human monoclonal antibody by in vitro immunization and the phage display method
    Shin ei Matsumoto
    Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Immunol Methods 332:2-9. 2008
    ..We thus established a rapid, efficient method to obtain antigen-specific human antibody genes and produce human monoclonal IgG antibody using the phage antibody library generated from in vitro immunized PBMCs...
  58. ncbi Prostate-specific antigen detection by using a reusable amperometric immunosensor based on reversible binding and leasing of HRP-anti-PSA from phenylboronic acid modified electrode
    Songqin Liu
    Jiangsu Provincial Key Laboratory of Biomaterials and Biodevices, Southeast University, Nanjing, 210096, People s Republic of China
    Clin Chim Acta 395:51-6. 2008
    ..It is important to develop reusable immunologically-sensitive elements for prostate-specific antigen (PSA) detection...
  59. ncbi Analysis of bispecific monoclonal antibody binding to immobilized antigens using an optical biosensor
    D A Dmitriev
    Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, 119992 Russia
    Biochemistry (Mosc) 67:1356-65. 2002
    ..In general, the data obtained indicate that Babs bearing an enzyme-binding site may not be efficiently used instead of traditional antibody-enzyme conjugates in the case of binding of bivalent Mabs...
  60. ncbi Antibodies elicited by the secretions from schistosome cercariae and eggs are predominantly against glycan epitopes
    T M Kariuki
    Institute of Primate Research, National Museums of Kenya, Nairobi
    Parasite Immunol 30:554-62. 2008
    ..Our data further support the hypothesis that antiglycan responses are a smokescreen with negligible protective potential...
  61. ncbi Immunology. Isomeric antibodies
    Jefferson Foote
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 299:1327-8. 2003
  62. ncbi TNT detection using multiplexed liquid array displacement immunoassays
    George P Anderson
    Center for Bio Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA
    Anal Chem 78:2279-85. 2006
    ..Seawater required dilution with two parts buffer to avoid loss of microspheres, while the acetone extracts were diluted 100-fold or more to minimize solvent affects...
  63. pmc Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease
    Aristo Vojdani
    Section of Neuroimmunology, Immunosciences Lab, Inc, 8693 Wilshire Blvd, Suite 200, Beverly Hills, CA 90211, USA
    Clin Diagn Lab Immunol 11:515-24. 2004
    ..Dysfunctional membrane peptidases and autoantibody production may result in neuroimmune dysregulation and autoimmunity...
  64. ncbi Airway biofilms: implications for pathogenesis and therapy of respiratory tract infections
    Hiroyuki Kobayashi
    First Department of Internal Medicine, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo, Japan
    Treat Respir Med 4:241-53. 2005
    ..The harmful reactions are mediated by alginate, which induces antigen antibody reactions around the airways, as well as formation of circulating immune complexes that are deposited on lung ..
  65. pmc Real-time label-free detection of complement activation products in human serum by white light reflectance spectroscopy
    Panagiota S Petrou
    Institute of Radioisotopes and Radiodiagnostic Products, NCSR Demokritos, GR 15310 Aghia Paraskevi, Greece
    Biosens Bioelectron 24:3359-64. 2009
    ..Thus, this novel assay method can be used to monitor serum C3b produced as a result of complement activation in a variety of normal and pathologic conditions...
  66. ncbi [Pharmacological and clinical properties of levocabastine hydrochloride (eye drop and nasal spray), a selective H1 antagonist]
    Megumi Akiyoshi
    Nonclinical Group, Janssen Pharmaceutical K K, 1 5 Higashi gotanda 3 chome, Shinagawa ku, Tokyo 141 8633, Japan
    Nihon Yakurigaku Zasshi 119:175-84. 2002
    ..With these pharmacological effects and topical usage, levocabastine was shown to be useful for allergic conjunctive and rhinitis in both seasonal and perennial clinical use...
  67. ncbi Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast cells activated with specific antigen-antibody reactions
    J Y Ro
    Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea
    J Pharmacol Exp Ther 292:114-21. 2000
  68. ncbi Terpenoids and glycolipids from euphorbiaceae
    F Cateni
    Department of Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy
    Mini Rev Med Chem 3:425-37. 2003
    ..These molecules may function as endogenous modulators of cell function and possibly as second messengers...
  69. ncbi ABO reverse grouping: effect of varying concentrations of the enzyme bromelain
    L E Rookard
    Donor Testing Centre, National Blood Service, Brentwood, Essex, UK
    Br J Biomed Sci 66:93-7. 2009
    ..This study identified limitations and problems with the methods used and presents recommendations for future research which may assist in the clarification of the role of proteolytic enzymes in ABO reverse grouping...
  70. ncbi Capacitive monitoring of protein immobilization and antigen-antibody reactions on monomolecular alkylthiol films on gold electrodes
    V M Mirsky
    University of Regensburg, Institute of Analytical Chemistry, Chemo and Biosensors, Regensburg, Germany
    Biosens Bioelectron 12:977-89. 1997
    ..Specifically, antibodies to human serum albumin were immobilized on the alkylthiol mono-layer. Binding of the antigen led to a decrease of the electrode capacitance. The detection limit of the immunosensor is as low as 15 nM (1 mg/l)...
  71. ncbi Inhibitory effect of levocabastine on experimental allergic conjunctivitis in guinea pigs
    C Kamei
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    J Pharmacobiodyn 14:467-73. 1991
    ..Furthermore, levocabastine prevented an increase in the vascular permeability elicited by both Hi and antigen instillation...
  72. ncbi Inhibitory effect of ginsenoside on the mediator release in the guinea pig lung mast cells activated by specific antigen-antibody reactions
    J Y Ro
    Department of Pharmacology, Yonsei University, College of Medicine, Seoul, Korea
    Int J Immunopharmacol 20:625-41. 1998
    ..Furthermore, Rb1 reduces the phosphatidylcholine production by inhibiting the methyl-transferase I and II, and the reduction of phosphatidylcholine production inhibits leukotriene release...
  73. ncbi Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissues
    Eva Maria Fabricius
    Charite Universitatsmedizin, Campus Virchow Hospital, Clinic for Oral and Maxillofacial Surgery, Berlin, Germany
    Int J Oncol 35:1377-94. 2009
    ..Finally, we compared the hTERT expression in BCC tissues with the hTERT scores in HNSCC tissues from our previous study. Only one anti-hTERT antibody (our Ab 7) yielded significantly higher scores in BCC than in HNSCC...
  74. ncbi A new concept of accommodation in ABO-incompatible kidney transplantation
    Kota Takahashi
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Clin Transplant 19:76-85. 2005
    ..In other words, bone marrow-derived histo-blood type regulates the histo-blood type of the organs...
  75. ncbi [Severe adverse event following iv administration of 10 ml 6% Dextran60 (0.6 g) in a healthy volunteer]
    G Lehmann
    Institut für Experimentelle Anästhesiologie der Johann Wolfgang Goethe Universität Frankfurt, Germany
    Anaesthesist 51:820-4. 2002
    ..e. 0.6 g) are infused. This is becoming more and more important due to the increasing use of "small volume resuscitation", solutions containing dextran (RescueFlow((R)), Biophausia AB, Uppsala, Schweden) or cryoconservation with dextran...
  76. ncbi Membrane-associated carbonic anhydrase IV in skeletal muscle: subcellular localization
    B Decker
    Abteilung Zellbiologie und Elektronenmikroskopie, Medizinische Hochschule Hannover, Germany
    Histochem Cell Biol 106:405-11. 1996
    ..Conceivably, the presence of SR staining in ultrathin sections and its absence in semithin sections reflect a problem of accessibility of the antigenic sites...
  77. ncbi Immunohistochemical study on the chicken adenohypophysis using monoclonal mouse anti-human FSH as a primary antibody
    H Erdost
    Department of Histology and Embryology, Uludağ University School of Veterinary, Bursa, Turkey
    Anat Histol Embryol 33:49-52. 2004
    ..Secondly, the incubation with the primary antibody (dilution 1/100 for anti-FSH) at 37 degrees C for 90 min...
  78. ncbi Current issues in species identification for forensic science and the validity of using the cytochrome oxidase I (COI) gene
    Linzi Wilson-Wilde
    ANZPAA National Institute of Forensic Science, Melbourne, Vic, Australia
    Forensic Sci Med Pathol 6:233-41. 2010
    ..techniques commonly utilized in Australian Forensic Science laboratories are gel immunodifussion antigen antibody reactions and hair comparison analysis...
  79. ncbi Protamine-associated hypotension in patients on hemodialysis: retrospective study and prevalence of antiprotamine antibodies
    Y T Tsai
    Division of Cardiovascular Surgery, Department of Surgery, Tri Service General Hospital, Taipei, Taiwan, ROC
    Clin Nephrol 72:122-8. 2009
    ..The objective of this study is to investigate whether patients on hemodialysis are more susceptible to the protamine adverse effects...
  80. ncbi Operation of acoustic plate mode immunosensors in complex biological media
    R Dahint
    Angewandte Physikalische Chemie, Universitaet Heidelberg, Germany
    Anal Chem 71:3150-6. 1999
    ..While the observed frequency shifts are comparable to those measured in pure buffer solutions, the binding process is accompanied by additional acoustic loss, indicating changes in the viscoelastic properties of the interfacial layer...
  81. ncbi RNA aptamer-based optical nanostructured sensor for highly sensitive and label-free detection of antigen-antibody reactions
    Ha Minh Hiep
    Department of Applied Physics, Graduate School of Engineering, Osaka University, Suita, Osaka 565 0871, Japan
    Anal Bioanal Chem 396:2575-81. 2010
    ..1 ng/mL. These nanostructured sensor-based models will open a way to display numerous immunosensors as well as to develop other functionally similar sensors which could then be expanded into multi-arrays assay systems...
  82. ncbi [Advances in identification of semen stains]
    Guang Yao Fan
    School of Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan 471003, China
    Zhonghua Nan Ke Xue 16:735-40. 2010
    ..Further more, studies on tis-sue-specific differential DNA methylation will provide a scrumptious way of identifying difficult samples...
  83. ncbi Capacitive monitoring of the antigen-antibody reactions enhanced by nanogold
    X S Guo
    Biosensor National Special Laboratory, Department of Biomedical Engineering Department of Biosystems Engineering, Zhejiang University, Hang Zhou 310027, P R China E mail Fax 86 571 87951676
    Conf Proc IEEE Eng Med Biol Soc 2:1260-3. 2005
    ..The result showed the capacity of the electrical double layer by nanogold enhancement was largely increased compared to that in traditional capacitive immunosensor. The detection sensitivity is up to 10nF / &#956;g/ml...
  84. ncbi Loop mediated isothermal amplification combined with nucleic acid lateral flow strip for diagnosis of cyprinid herpes virus-3
    Hatem Soliman
    Fish Medicine and Livestock Management, University of Veterinary Medicine, Vienna, Austria
    Mol Cell Probes 24:38-43. 2010
  85. ncbi Immunohistological evaluation of immune cell infiltrate in cutaneous Kaposi's sarcoma
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut, Egypt
    Cell Biol Int 32:157-62. 2008
    ..However, these issues should be tested by further studies...
  86. ncbi Comparison of blocking agents for an ELISA for LPS
    Z Peterfi
    Department of Medical Microbiology and Immunology, University Medical School of Pecs, Hungary
    J Immunoassay 21:341-54. 2000
    ..This modification increases the sensitivity of ELISA. This method is useful for detection of LPS (S, R form) and anti-LPS antibody reaction in serological cross-reaction studies...
  87. pmc Development of an ultrasound-emitting device for performing rapid immunostaining procedures
    Hideki Hatta
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Histochem Cytochem 58:421-8. 2010
    ..Finally, we tried immunostaining with the ultrasonic generator using frozen specimens to simulate intraoperative rapid diagnosis. We report herein that ultrasound enables immunostaining of frozen specimens in approximately 10 min...
  88. ncbi Characterization of the epitope recognized by a monoclonal antibody highly specific for blood group M antigen
    E Jaskiewicz
    Department of Immunochemistry, Polish Academy of Sciences, Wroclaw
    Transfusion 30:230-5. 1990
    ..The reaction of the antibody with blood group N antigen was not detectable in any of the assays used...
  89. ncbi Antigen-antibody binding kinetics for biosensor applications. A dual-fractal analysis
    A Sadana
    Chemical Engineering Department, University of Mississippi 38677 9740, USA
    Appl Biochem Biotechnol 62:275-90. 1997
  90. ncbi Multichannel wireless-electrodeless quartz-crystal microbalance immunosensor
    Hirotsugu Ogi
    Graduate School of Engineering Science, Osaka University, Machikaneyama 1 3, Toyonaka, Osaka 560 8531, Japan
    Anal Chem 82:3957-62. 2010
    ..The exponential coefficient of the frequency change, rather than the amount of the frequency decrease, is found to be useful for distinguishing between specific and nonspecific binding reactions...
  91. ncbi Nephritogenicity and immunocytochemical localization of the 70-kilodalton glycoprotein subunit (gp70) of Heymann antigen
    A K Singh
    Department of Nephrology, Rush Medical College, Chicago, Illinois 60612
    Clin Immunol Immunopathol 48:61-77. 1988
    ..The presence of gp70 on the endothelial side of the GBM is consistent with a role for in situ antigen-antibody reactions at sites other than the subepithelial region in the pathogenesis of HN...
  92. ncbi A classification of drug substances according to their mechanism of action
    P Imming
    Fachbereich Pharmazie, Philipps Universitat, Marburg, Germany
    Pharmazie 59:579-89. 2004
    ..This target-oriented approach may be particularly useful in teaching advanced medicinal chemistry...
  93. ncbi Use of a 203 alphaalpha fragment of Tc-PDI to detect IgA activity during infection by Teladorsagia circumcincta in sheep
    M Martinez-Valladares
    Departamento de Sanidad Animal, Parasitologia, Facultad de Veterinaria, Universidad de Leon, 24071 Leon, Spain
    Parasitol Res 100:1213-20. 2007
    ..Nevertheless, the ELISA technique using the somatic antigen cannot be standardized, and the antigen-antibody reactions are more unspecific; therefore, the recombinant Tc-PDI could be a better option...
  94. ncbi Design and simulation of active biochip system
    Wenwei Zhu
    Institute of Genetic Diagnosis, The Fourth Military Medical University, Xi an 710032, PR China
    Biomed Microdevices 7:157-60. 2005
    ..Computational simulation demonstrated that this system is a rapid, stable, robust and practical system that may enhance the efficiency of antigen-antibody reactions and improve the repeatability and accuracy of biochip analysis...
  95. ncbi Antimitochondrial antibodies and reactivity to N. aromaticivorans proteins in Icelandic patients with primary biliary cirrhosis and their relatives
    Sigurdur Olafsson
    Department of Internal Medicine, Landspitali University Hospital, Reykjavik, Iceland
    Am J Gastroenterol 99:2143-6. 2004
    ..aromaticivorans might be the trigger of autoimmunity in PBC. No data are available on the specificity and crossreactivity of AMA in a genetically homogenous group of patients, such as the Icelandic population...
  96. ncbi A novel competitive fluorescence immunoassay for the determination of dibutyl phthalate
    Ming Cui Zhang
    College of Environmental Science and Engineering, Donghua University, Shanghai 201620, People s Republic of China
    Anal Bioanal Chem 386:1401-6. 2006
  97. ncbi Characterization of antibody-antigen interactions by fluorescence spectroscopy
    Sotiris Missailidis
    Department of Chemistry, The Open University, Milton Keynes, UK
    Methods Mol Biol 248:431-41. 2004
  98. pmc Label-free biomarker detection from whole blood
    Eric Stern
    Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven, Connecticut 06511, USA
    Nat Nanotechnol 5:138-42. 2010
    ..This study marks the first use of label-free nanosensors with physiological solutions, positioning this technology for rapid translation to clinical settings...
  99. ncbi Perspectives on the neutralization of interferons by antibody
    Sidney E Grossberg
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurology 61:S21-3. 2003
  100. ncbi Antibodies use heme as a cofactor to extend their pathogen elimination activity and to acquire new effector functions
    Jordan D Dimitrov
    Department of Immunology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Bonchev Street, 1113 Sofia, Bulgaria
    J Biol Chem 282:26696-706. 2007
    ..The potentiation of the antibacterial activity of IgG after contact with heme may represent a novel and inducible innate-type defense mechanism against invading pathogens...
  101. ncbi Effective antigen-retrieval method for immunohistochemical detection of abnormal isoform of prion proteins in animals
    Hidefumi Furuoka
    Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine, 080 8555, Obihiro, Japan
    Acta Neuropathol 109:263-71. 2005
    ..Based on the differences of reaction among the antibodies, we also discuss the mechanisms of the hydrated autoclaving methods to retrieve PrP(Sc) immunoreactivity...

Research Grants66

  1. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
  2. Alloimmunization to mHAs by RBC Transfusion
    JAMES ZIMRING; Fiscal Year: 2007
    ..By analyzing transfusion patients at Emory, we will determine the extent to which females receiving leukoreduced RBC from male donors are immunized to H-Y antigens. [unreadable] [unreadable] [unreadable]..
  3. CD8 + CD75s + regulatory T cells in anti-tumor immunity
    JAMES ZIMRING; Fiscal Year: 2007
    ..These aims propose to investigate the role that negative regulatory T cells play in the establishment of immunological tolerance to tumor antigens and the fashion in which their elimination can result in tumor rejection. ..
  4. Induction of Immunological Tolerance for Gene Therapy
    JAMES ZIMRING; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  5. Selective depletion of alloreactive T cells in BMT
    JAMES ZIMRING; Fiscal Year: 2005
    ..In keeping with the stated purpose of this RFA, these studies represent the "development and application of cell engineering methods to predictably induce tolerance..." ..
  6. The role of Ach in CD8+ Cytolytic T cell development
    JAMES ZIMRING; Fiscal Year: 2005
    ..abstract_text> ..
  7. Enhancing axon regeneration by multi-inhibitor blocking
    RONALD SCHNAAR; Fiscal Year: 2005
    ..The resulting data may provide insight on the relative contributions of the different ARI's in an in vivo model, and may support evaluation of new approaches to enhance axon regeneration after CNS injury. ..
  8. The reversal of multidrug resistance by an anti-CD19 ab.
    Ellen Vitetta; Fiscal Year: 2006
    ..abstract_text> ..
  9. Brugia Infections in Mice: Role of Eosinophils
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
    ..We believe that the studies proposed herein will help us understand the mechanisms by which mammalian hosts combat infectious agents that are far larger than their own effector cells. ..
  10. Technology for DNA Damage Analysis and Biomarkers
    X Le; Fiscal Year: 2004
    ..The technology will also be useful for monitoring DNA damage induced by anticancer agents and for studying DNA repair, which is an essential protection mechanism against cancer initiation. ..
  11. Novel HIV Neutralizing Human MAbs from Transgenic Mice
    Abraham Pinter; Fiscal Year: 2006
  12. Plant Viruses as Platforms for Biomaterials
    John Johnson; Fiscal Year: 2006
  13. Rare Antigens in Neonatal Alloimmune Thrombocytopenia
    Julie Peterson; Fiscal Year: 2006
    ..4. Generate soluble recombinant platelet glycoproteins carrying "rare" platelet alloantigens to provide a tool for rapid detection and identification of antibodies in mothers who are immunized against these antigens ..
  14. Vaccine-elicited genital and neuronal T cell responses
    Gregg Milligan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  15. Complement-fixing Bi-Specific Antibodies Against HIV-1
    ROBERT BOACKLE; Fiscal Year: 2007
    ..Our third objective is to evaluate the complement-mediated neutralization of infectious HIV-1 particles by paired combinations of the truncated bi-specific antibodies. [unreadable] [unreadable] [unreadable]..
  16. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
    Ellen Vitetta; Fiscal Year: 2009
    ..Doses of 1, 10 and 100 micrograms - each with 0.5 mg Alhydrogel, will be given at weeks 0, 6, and 26 and serum will be assessed for anti-vaccine and neutralizing titers. ..
  18. Desferrithiocin Analogue Actinide Decorporation Agents
    RAYMOND BERGERON; Fiscal Year: 2008
    ..abstract_text> ..
  19. Using Nanotechnology to Regulate Integrin Clustering and Tensin Localization
    Gang yu Liu; Fiscal Year: 2008
    ..This nanoengineering approach should provide a new paradigm for controlling cell signaling and behavior, which enables new methods be developed for cancer therapy. [unreadable] [unreadable] [unreadable]..
  20. Minor H Antigen Regulatory Networks as an Alternative to Calcineurin Inhibitors i
    WILLIAM BURLINGHAM; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. Helical Rosette Nanotubes for Treating Osteoporotic Bone
    Thomas Webster; Fiscal Year: 2008
    ..abstract_text> ..
  22. Targeting myeloma via dendritic cells
    Madhav Dhodapkar; Fiscal Year: 2009
    ..abstract_text> ..
    THIRUCHANDURAI RAJAN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
    Abraham Pinter; Fiscal Year: 2010
    Xiaohong Xu; Fiscal Year: 2001
    ..The associated cellular signaling pathways (e.g., hydrolysis of inositol phospholipids in the plasma membrane, increase in intracellular second messenger levels) will be monitored in real-time using SM chemical microscopy. ..
    MICHAEL LAMM; Fiscal Year: 2002
  27. IgA1-Regulation of Complement in Periodontal Disease
    ROBERT BOACKLE; Fiscal Year: 2002
    Ellen Vitetta; Fiscal Year: 2001
    ..These tumors will be used as targets for therapy. To this end, she has initiated collaborations at her institution and at two other institutions for the acquisition of fresh lymphomas. ..
    Gregory Spear; Fiscal Year: 2003
    ..3. Utilize inhibitors of glycosylation to enhance biological effects of MBL. Exarnine the interaction of MBL with anti-viral antibodies in mediating anti-viral effects. Deterrnine the interaction of HIV-1 with MBL in vivo. ..
    Uri Galili; Fiscal Year: 2003
    ..Success in these studies will help in planning effective treatments for preventing anti-Gal response in primate xenografts recipients. | ..
  31. Peroxisome Membrane Biogenesis
    Stephen Gould; Fiscal Year: 2004
    ..abstract_text> ..
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to develop a working model of how donor-derived leukocytes and the antigens they release contribute to a tonic equilibrium between host T regulator and effector cells in human allograft acceptance. ..
  33. Age-related structural alterations in loss of self-tolerance to a3(IV) collagen
    Dorin Bogdan Borza; Fiscal Year: 2007
    ..New targets for prevention or therapeutic intervention may be identified as a result. [unreadable] [unreadable] [unreadable] [unreadable]..
    RONALD SCHNAAR; Fiscal Year: 2004
    John Johnson; Fiscal Year: 2002
    ..We also seek to encourage unconventional aspects of virology as represented at our last meeting by presentations describing plant viruses as bio materials and nano reaction vessels. ..
  36. Phosphorylatable Monoclonal Antibodies for Tumor Therapy
    William Clark; Fiscal Year: 2003
    ..The extensive advantages of PBL's phosphorylation technology can be exploited for virtually any anticancer MAb in development, in clinical trials, or already in use, including MAbs designed to treat human melanoma...
  37. Deciphering toxin neutralization by oligoclonal antibody
    James Marks; Fiscal Year: 2003
    ..In addition, this approach would be applicable to four of the other Class A agents (anthrax, smallpox, plague, and hemorrhagic fever viruses). ..
  38. Nanocapillary Electrophoresis for Profiling Cancer
    Arunava Majumdar; Fiscal Year: 2003
    ..This technology would directly address this important public health issue. ..
    John Johnson; Fiscal Year: 2001
  40. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2008
    ..abstract_text> ..
  41. Recombinant Sendai Virus as a Novel HIV Vaccine Vector
    KAREN SLOBOD; Fiscal Year: 2004
    ..Studies described in this application may ultimately identify rSV as an effective intranasal vaccine vehicle useful in the prevention of HIV. ..
  42. Enhancement of targeting HIV vaccine to dendritic cell
    Sang Moo Kang; Fiscal Year: 2004
    ..As a long-term objective, the efficacy of targeting VLPs to DCs will be tested in a non-human primate model for designing a more effective AIDS vaccine. ..
    THIRUCHANDURAI RAJAN; Fiscal Year: 2005
    Gregg N Milligan; Fiscal Year: 2010
    ..The results of these studies should be important for the rational development of HSV vaccines as well as understanding the cellular interactions and specific molecular mechanisms required for resolution of HSV lesions. ..
    Michael Zwick; Fiscal Year: 2005
    ..A panel of mAbs against the described epitopes on gp41 will provide valuable tools to aid in HIV-1 vaccine design. ..
  46. Assessing Protein Interactions in Cells by Fluorescence
    William Clark; Fiscal Year: 2003
    THIRUCHANDURAI RAJAN; Fiscal Year: 2001
    ..Identification of the molecule(s) involved in the interaction could help us formulate a rationale approach to immunoprophylaxis, as well as pharmacology of lymphatic filarial parasites. ..
    Uri Galili; Fiscal Year: 2005
    ..We will then also collaborate with a group studying immune responses in monkeys to determine the efficacy of this vaccine in a primate model. ..
    Ellen Vitetta; Fiscal Year: 2003
    ..This is a preclinical study to evaluate a new therapeutic modality. Our results should determine the feasibility of a future clinical trial. ..
  50. Nanoassay for Realtime Molecular Probing ABC Transporter
    X NANCY XU; Fiscal Year: 2010
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to establish the basis for a rational approach to HLA-matching and selective NIMA mismatching to achieve the goal of clinical kidney transplantation tolerance. ..
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..
  53. Development of botulinum neurotoxin immunotherapy
    James Marks; Fiscal Year: 2007
    ..Such information will be invaluable for vaccine development as well as diagnostic testing and microbial forensics. ..
  54. Oral Delivery of DNA Vaccines
    FRANK ORSON; Fiscal Year: 2003
  55. Development & Manufacture of an MDR Tuberculosis Vaccine
    Steven Reed; Fiscal Year: 2005
    ..This will enable us to immediately proceed to human clinical trials after the end of the funding period. ..
  56. Microbial Fingerprinting Chip and Automated Analysis
    DON DALY; Fiscal Year: 2003
    ..Because the method and DNA chip is "universal", it may be applicable for the identification of other microorganism, as demonstrated in our preliminary studies with Salmonella, Xanthomonas and E. coli pathogens. ..
  57. A Novel Recombinant Protein Vaccine Against Ricin Toxin
    Ellen Vitetta; Fiscal Year: 2006
    ..When these three aims are completed, the vaccine should be ready for acute toxicology studies in two species and scale-up for Phase 1 clinical trials in humans. [unreadable] [unreadable]..
  58. Exacerbation of Atherosclerosis
    Guangming Zhong; Fiscal Year: 2004
    ..pneumoniae exacerbation of atherosclerosis will be evaluated. These studies may provide the essential information on designing effective approaches for preventing and controlling C. pneumoniae-exacerbated atherosclerosis. ..
  59. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
  60. Immunotoxin-Induced Vascular Leak Syndrome
    Ellen Vitetta; Fiscal Year: 2005
    ..3) whether there are correlations between PKs, changes in cytokines, toxicity, and response. Our data will be compared with those obtained in the past clinical trials with the second generation IT, RFB4-dgRTA. ..
    RAYMOND BERGERON; Fiscal Year: 2004
  62. TCRb CDR3 and Susceptibility to Autoimmune Disease
    Harry Schroeder; Fiscal Year: 2003
    ..These experiments will also shed light on the role of potentially abnormal TCR sequence in promoting lupus and other autoimmune diseases. ..
    Pojen Chen; Fiscal Year: 2007
    ..abstract_text> ..
    Harry Schroeder; Fiscal Year: 2005
    ..Finally, the effect that alteration of HCDR3 has on the development of the natural autoantibody repertoire and on the progression of autoimmune disease in the MRL-lpr/lpr mouse will be examined. ..