organ specificity

Summary

Summary: Restriction of a characteristic or response to a particular organ of the body; it usually refers to that property of the immune response which differentiates one organ from another on the basis of antigen recognition, but the concept is not limited to immunology.

Top Publications

  1. pmc Alternative isoform regulation in human tissue transcriptomes
    Eric T Wang
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 456:470-6. 2008
  2. ncbi Identification of tissue-specific microRNAs from mouse
    Mariana Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Curr Biol 12:735-9. 2002
  3. pmc Conserved role of intragenic DNA methylation in regulating alternative promoters
    Alika K Maunakea
    Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158, USA
    Nature 466:253-7. 2010
  4. ncbi Genome-wide atlas of gene expression in the adult mouse brain
    Ed S Lein
    Allen Institute for Brain Science, Seattle, Washington 98103, USA
    Nature 445:168-76. 2007
  5. ncbi Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    Lee P Lim
    Rosetta Inpharmatics, Merck and Co, 401 Terry Avenue N, Seattle, Washington 98109, USA
    Nature 433:769-73. 2005
  6. ncbi Identification of novel genes coding for small expressed RNAs
    M Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Science 294:853-8. 2001
  7. pmc A highly efficient recombineering-based method for generating conditional knockout mutations
    Pentao Liu
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Genome Res 13:476-84. 2003
  8. ncbi Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
    Bioinformatics 21:650-9. 2005
  9. pmc Tissue specificity and the human protein interaction network
    Alice Bossi
    EMBL CRG Systems Biology Unit, Centre for Genomic Regulation, UPF, Barcelona, Spain
    Mol Syst Biol 5:260. 2009
  10. ncbi A pancreatic islet-specific microRNA regulates insulin secretion
    Matthew N Poy
    Laboratory of Metabolic Diseases and Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 432:226-30. 2004

Detail Information

Publications311 found, 100 shown here

  1. pmc Alternative isoform regulation in human tissue transcriptomes
    Eric T Wang
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 456:470-6. 2008
    ....
  2. ncbi Identification of tissue-specific microRNAs from mouse
    Mariana Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Curr Biol 12:735-9. 2002
    ..Finally, a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA...
  3. pmc Conserved role of intragenic DNA methylation in regulating alternative promoters
    Alika K Maunakea
    Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158, USA
    Nature 466:253-7. 2010
    ..These results support a major role for intragenic methylation in regulating cell context-specific alternative promoters in gene bodies...
  4. ncbi Genome-wide atlas of gene expression in the adult mouse brain
    Ed S Lein
    Allen Institute for Brain Science, Seattle, Washington 98103, USA
    Nature 445:168-76. 2007
    ..This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function...
  5. ncbi Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    Lee P Lim
    Rosetta Inpharmatics, Merck and Co, 401 Terry Avenue N, Seattle, Washington 98109, USA
    Nature 433:769-73. 2005
    ..Moreover, miR-1 and miR-124, and presumably other tissue-specific miRNAs, seem to downregulate a far greater number of targets than previously appreciated, thereby helping to define tissue-specific gene expression in humans...
  6. ncbi Identification of novel genes coding for small expressed RNAs
    M Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Science 294:853-8. 2001
    ..This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated...
  7. pmc A highly efficient recombineering-based method for generating conditional knockout mutations
    Pentao Liu
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Genome Res 13:476-84. 2003
    ..This method should also facilitate the generation of knock-in mutations and transgene constructs, as well as expedite the analysis of regulatory elements and functional domains in or near genes...
  8. ncbi Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
    Bioinformatics 21:650-9. 2005
    ..Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of expression...
  9. pmc Tissue specificity and the human protein interaction network
    Alice Bossi
    EMBL CRG Systems Biology Unit, Centre for Genomic Regulation, UPF, Barcelona, Spain
    Mol Syst Biol 5:260. 2009
    ..These results suggest a model for the evolution of tissue-specific biology, and show that most, and possibly all, 'housekeeping' proteins actually have important tissue-specific molecular interactions...
  10. ncbi A pancreatic islet-specific microRNA regulates insulin secretion
    Matthew N Poy
    Laboratory of Metabolic Diseases and Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 432:226-30. 2004
    ..Thus, miR-375 is a regulator of insulin secretion and may thereby constitute a novel pharmacological target for the treatment of diabetes...
  11. pmc Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns
    Alicia Lundby
    Novo Nordisk Foundation Center for Protein Research, Department for Proteomics, Faculty of Health Sciences, University of Copenhagen, Denmark
    Cell Rep 2:419-31. 2012
    ..Furthermore, we illustrate that acetylation of fructose-bisphosphate aldolase and glycerol-3-phosphate dehydrogenase serves as a cellular mechanism to switch off enzymatic activity...
  12. ncbi MicroRNA expression in zebrafish embryonic development
    Erno Wienholds
    Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands
    Science 309:310-1. 2005
    ....
  13. ncbi Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    Nataliya Libina
    Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 115:489-502. 2003
    ..We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal...
  14. ncbi A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
    Georg Dietzl
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Nature 448:151-6. 2007
    ..Our transgenic RNAi library thus opens up the prospect of systematically analysing gene functions in any tissue and at any stage of the Drosophila lifespan...
  15. pmc TiGER: a database for tissue-specific gene expression and regulation
    Xiong Liu
    Wilmer Institute, Johns Hopkins University School of Medicine, Maumenee Building 844, 600 N, Wolfe Street, Baltimore, MD 21287, USA
    BMC Bioinformatics 9:271. 2008
    ..Understanding how genes are expressed and regulated in different tissues is a fundamental and challenging question. However, most of currently available biological databases do not focus on tissue-specific gene regulation...
  16. pmc Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent
    Joseph E Powell
    Queensland Institute of Medical Research, Herston, Brisbane, QLD 4006, Australia
    Genome Res 22:456-66. 2012
    ....
  17. ncbi A molecular signature of metastasis in primary solid tumors
    Sridhar Ramaswamy
    Whitehead Institute MIT Center for Genome Research, One Kendall Square, Building 300, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:49-54. 2003
    ..These results suggest that the metastatic potential of human tumors is encoded in the bulk of a primary tumor, thus challenging the notion that metastases arise from rare cells within a primary tumor that have the ability to metastasize...
  18. ncbi Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    Yong Zhao
    Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nature 436:214-20. 2005
    ..This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis...
  19. ncbi Tissue-specific demethylation in CpG-poor promoters during cellular differentiation
    Genta Nagae
    Genome Science Division, Research Center for Advanced Science and Technology and Department of Pathology, University of Tokyo, Tokyo, Japan
    Hum Mol Genet 20:2710-21. 2011
    ..These results illuminate tissue-specific methylation dynamics in CpG-poor promoters and provide more comprehensive views on spatiotemporal gene regulation in terminal differentiation...
  20. pmc A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes
    Kasper Lage
    Center for Biological Sequence Analysis, Kemitorvet building 208, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Proc Natl Acad Sci U S A 105:20870-5. 2008
    ..Our method represents a conceptual scaffold for organism-spanning analyses and reveals an extensive list of tissue-specific draft molecular pathways, both known and unexpected, that might be disrupted in disease...
  21. ncbi Developmental programming of CpG island methylation profiles in the human genome
    Ravid Straussman
    Department of Cellular Biochemistry and Human Genetics, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nat Struct Mol Biol 16:564-71. 2009
    ..In short, we show that UMRs are an important aspect of genome structure that have a dynamic role in development...
  22. pmc Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin
    Kevin Wilhelmsen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Cell Biol 171:799-810. 2005
    ....
  23. pmc Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
    Alexander Stark
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02140, USA
    Nature 450:219-32. 2007
    ..We also study how discovery power scales with the divergence and number of species compared, and we provide general guidelines for comparative studies...
  24. pmc Stars and symbiosis: microRNA- and microRNA*-mediated transcript cleavage involved in arbuscular mycorrhizal symbiosis
    Emanuel A Devers
    Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam Golm, Germany
    Plant Physiol 156:1990-2010. 2011
    ..In summary, the increased accumulation of specific miRNAs and the miRNA-mediated cleavage of symbiosis-relevant genes indicate that miRNAs are an important part of the regulatory network leading to symbiosis development...
  25. ncbi Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel
    Yuriy Kirichok
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital and Harvard Medical School Enders 1309, Boston, Massachusetts 02115, USA
    Nature 439:737-40. 2006
    ..Our results identify CatSper1 as a component of the key flagellar calcium channel, and suggest that intracellular alkalinization potentiates CatSper current to increase intraflagellar calcium and induce sperm hyperactivation...
  26. pmc Tissue-specific genetic control of splicing: implications for the study of complex traits
    Erin L Heinzen
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, USA
    PLoS Biol 6:e1. 2008
    ....
  27. pmc Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development
    Ping Liang
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada
    BMC Genomics 12:231. 2011
    ..It is necessary to identify these events so that we may understand how these changes affect normal development and how aberrant changes may impact disease...
  28. pmc Variation in tissue-specific gene expression among natural populations
    Andrew Whitehead
    Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA
    Genome Biol 6:R13. 2005
    ..To address this we examined the expression of a selected suite of 192 metabolic genes in brain, heart and liver in three populations of the teleost fish Fundulus heteroclitus using a highly replicated experimental design...
  29. ncbi TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta
    Fenghua Yi
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G 2M1, Canada
    J Biol Chem 280:1457-64. 2005
    ..We have therefore identified a unique mechanism that regulates glu expression in gut endocrine cells only. Tissue-specific expression of TCF factors thus may play a role in the diversity of the Wnt pathway...
  30. pmc The human keratins: biology and pathology
    Roland Moll
    Institute of Pathology, Philipps University, 35033, Marburg, Germany
    Histochem Cell Biol 129:705-33. 2008
    ..Future research might open further fields of clinical application for this remarkable protein family...
  31. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
    ..These findings establish that Peyer's patch dendritic cells imprint gut-homing specificity on T cells, and thus license effector/memory cells to access anatomical sites most likely to contain their cognate antigen...
  32. ncbi The widespread impact of mammalian MicroRNAs on mRNA repression and evolution
    Kyle Kai How Farh
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 310:1817-21. 2005
    ....
  33. ncbi Mammalian housekeeping genes evolve more slowly than tissue-specific genes
    Liqing Zhang
    Department of Ecology and Evolution, University of Chicago, USA
    Mol Biol Evol 21:236-9. 2004
    ..Therefore, the stronger selective constraints on housekeeping genes are not due to a lower degree of genetic redundancy...
  34. pmc miRNeye: a microRNA expression atlas of the mouse eye
    Marianthi Karali
    Telethon Institute for Genetics and Medicine, Via P Castellino 111, Naples, Italy
    BMC Genomics 11:715. 2010
    ..MicroRNAs (miRNAs) are key regulators of biological processes. To define miRNA function in the eye, it is essential to determine a high-resolution profile of their spatial and temporal distribution...
  35. ncbi The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
    Zhaohui Feng
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
    Cancer Res 67:3043-53. 2007
    ..Upon glucose starvation of E1A-transformed mouse embryo fibroblasts, a p53-mediated apoptosis ensues. Thus, there is a great deal of communication between the p53 pathway and the IGF-1-AKT and mTOR pathways...
  36. ncbi Phenotypic heterogeneity of the endothelium: II. Representative vascular beds
    William C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circ Res 100:174-90. 2007
    ....
  37. pmc Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila
    KyeongJin Kang
    National Center for Behavioral Genomics and Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 481:76-80. 2012
    ..These findings indicate that reducing thermosensitivity can be critical for TRP channel functional diversification, facilitating their use in contexts in which thermal sensitivity can be maladaptive...
  38. ncbi mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer
    P Tontonoz
    Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1224-34. 1994
    ....
  39. pmc DNA methylation profiling of human chromosomes 6, 20 and 22
    Florian Eckhardt
    Epigenomics AG, Kleine Präsidentstrasse 1, 10178 Berlin, Germany
    Nat Genet 38:1378-85. 2006
    ..Our data suggest DNA methylation to be ontogenetically more stable than previously thought...
  40. ncbi A novel multigene family may encode odorant receptors: a molecular basis for odor recognition
    L Buck
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 65:175-87. 1991
    ..The members of this novel gene family are likely to encode a diverse family of odorant receptors...
  41. ncbi Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes
    J P Silva
    Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Nat Genet 26:336-40. 2000
    ..This animal model reproduces the beta-cell pathology of human mitochondrial diabetes and provides genetic evidence for a critical role of the respiratory chain in insulin secretion...
  42. ncbi 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
    Jeremy W Tomlinson
    Endocrinology, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Endocr Rev 25:831-66. 2004
    ..Therapeutic inhibition of 11beta-HSD1 reductase activity in patients with obesity and the metabolic syndrome, as well as in glaucoma and osteoporosis, remains an exciting prospect...
  43. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
    ..As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases...
  44. ncbi Mechanisms of alternative pre-messenger RNA splicing
    Douglas L Black
    Department of Microbiology, Immunology, and Molecular Genetics, Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, California 90095 1662, USA
    Annu Rev Biochem 72:291-336. 2003
    ..How these regulators are combined into complex systems of tissue-specific splicing is discussed. In conclusion, very recent studies are presented that point to new directions for understanding alternative splicing and its mechanisms...
  45. ncbi A germline-specific class of small RNAs binds mammalian Piwi proteins
    Angelique Girard
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 442:199-202. 2006
    ..Although their function must still be resolved, the abundance of piRNAs in germline cells and the male sterility of Miwi mutants suggest a role in gametogenesis...
  46. ncbi Role for DNA methylation in the control of cell type specific maspin expression
    Bernard W Futscher
    Department of Pharmacology and Toxicology, Bone Marrow Transplant Program, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Nat Genet 31:175-9. 2002
    ..These findings indicate that cytosine methylation is important in the establishment and maintenance of cell type restricted gene expression...
  47. ncbi Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    Dae Sung Hwangbo
    Division of Biology and Medicine, Box G W, Brown University, Providence, Rhode Island 02912, USA
    Nature 429:562-6. 2004
    ..These findings suggest that autonomous and non-autonomous roles of insulin signalling combine to control ageing...
  48. ncbi Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues
    Q Zhang
    Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    J Cell Sci 114:4485-98. 2001
    ..These data and structural analogies with other proteins suggest that nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structural integrity...
  49. ncbi Entrainment of the circadian clock in the liver by feeding
    K A Stokkan
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
    Science 291:490-3. 2001
    ..They also raise the possibility that peripheral circadian oscillators like those in the liver may be coupled to the SCN primarily through rhythmic behavior, such as feeding...
  50. ncbi Extensive and divergent circadian gene expression in liver and heart
    Kai Florian Storch
    Department of Neurobiology, Harvard Medical School, Northeastern University, Boston, Massachusetts 02115, USA
    Nature 417:78-83. 2002
    ..A core set of 37 genes with similar circadian regulation in both tissues includes candidates for new clock genes and output genes, and it contains genes responsive to circulating factors with circadian or diurnal rhythms...
  51. ncbi The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
    Helen Skaletsky
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 423:825-37. 2003
    ..9% identity, which is maintained by frequent gene conversion (non-reciprocal transfer). The most prominent features here are eight massive palindromes, at least six of which contain testis genes...
  52. ncbi An extensive class of small RNAs in Caenorhabditis elegans
    R C Lee
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Science 294:862-4. 2001
    ..elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse...
  53. pmc Tissue-specific spatial organization of genomes
    Luis A Parada
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Genome Biol 5:R44. 2004
    ..It is unclear whether the nonrandom spatial arrangement of chromosomes is conserved among tissues or whether spatial genome organization is tissue-specific...
  54. pmc Making sense out of massive data by going beyond differential expression
    Patrick R Schmid
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge MA 02139, USA
    Proc Natl Acad Sci U S A 109:5594-9. 2012
    ..Finally, we provide an online resource (http://concordia.csail.mit.edu) for mapping users' gene expression samples onto the expression landscape of tissue and disease...
  55. ncbi Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis
    Laura Kennedy
    Division of Molecular Genetics, Faculty of Biomedical and Life Scienes, University of Glasgow, Anderson College Complex, 56 Dumbarton Road, Glasgow G11 6NU, UK
    Hum Mol Genet 12:3359-67. 2003
    ....
  56. pmc Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues
    Srimoyee Ghosh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Epigenetics 5:527-38. 2010
    ..Furthermore, there was an overall pattern of tissue specifically methylated CpG islands that distinguished neural tissues from non-neural...
  57. pmc Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein
    V Markovtsov
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles, California 90095, USA
    Mol Cell Biol 20:7463-79. 2000
    ....
  58. pmc Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
    Yukio Kawahara
    Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Science 315:1137-40. 2007
    ....
  59. pmc A CTCF-independent role for cohesin in tissue-specific transcription
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genome Res 20:578-88. 2010
    ....
  60. pmc The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells
    Linda Paavilainen
    Department of Genetics and Pathology, Uppsala University, Sweden
    J Histochem Cytochem 58:237-46. 2010
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  61. pmc Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
    Jian Liu
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 15:940-5. 2009
    ..Our results showing reduced obesity and diabetes in mice treated with clinically available mast cell-stabilizing agents suggest the potential of developing new therapies for these common human metabolic disorders...
  62. pmc New microRNAs from mouse and human
    Mariana Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 121, D 37077 Gottingen, Germany
    RNA 9:175-9. 2003
    ..A comprehensive collection of miRNAs is important for assisting bioinformatics target mRNA identification and comprehensive genome annotation...
  63. pmc Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts
    John A Calarco
    Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
    RNA 17:775-91. 2011
    ....
  64. ncbi Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
    Laura A Herndon
    Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, A232 Nelson Biological Laboratories, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nature 419:808-14. 2002
    ..Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals...
  65. pmc Probing microRNAs with microarrays: tissue specificity and functional inference
    Tomas Babak
    Banting and Best Department of Medical Research, 112 College St, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    RNA 10:1813-9. 2004
    ....
  66. pmc Genes duplicated by polyploidy show unequal contributions to the transcriptome and organ-specific reciprocal silencing
    Keith L Adams
    Department of Botany, Iowa State University, Ames, IA 50011, USA
    Proc Natl Acad Sci U S A 100:4649-54. 2003
    ..Both long-term and immediate responses to polyploidization were implicated. Data suggest that some silencing events are epigenetically induced during the allopolyploidization process...
  67. pmc Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice
    Ruey Sheng Wang
    Department of Pathology and Urology, George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endocr Rev 30:119-32. 2009
    ....
  68. ncbi Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    Sven Falk
    Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Stem Cell 2:472-83. 2008
    ..Thus, TGF-beta signaling controls the size of a specific brain area, the dorsal midbrain, by antagonizing canonical Wnt signaling and negatively regulating self-renewal of neuroepithelial stem cells...
  69. pmc Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues
    Thomas D Goldman
    Section of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 3:e216. 2007
    ..We show that dpr and dpr-expressing cells are required for the proper timing of male courtship behaviors...
  70. ncbi Expression and regulation of beta-defensin 11 in the oviduct in response to estrogen and in ovarian tumors of chickens
    Whasun Lim
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, 1 Gwanak ro, Gwanak Gu, Seoul 151 742, Republic of Korea
    Mol Cell Endocrinol 366:1-8. 2013
    ....
  71. pmc Sequence features that drive human promoter function and tissue specificity
    Jane M Landolin
    Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genome Res 20:890-8. 2010
    ..Our study underscores the importance of collecting functional information from complementary assays and conditions to understand biology in a systematic framework...
  72. ncbi Nodulation enhances dark CO₂ fixation and recycling in the model legume Lotus japonicus
    Mariangela N Fotelli
    Department of Agricultural Biotechnology, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece
    J Exp Bot 62:2959-71. 2011
    ..A potential mechanism is proposed for reducing carbon losses during SNF by the direct reincorporation of CO(2) respired by nodules and the transport and metabolism of C-containing metabolites in hypergeous organs...
  73. pmc Identification of reference genes across physiological states for qRT-PCR through microarray meta-analysis
    Wei Chung Cheng
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    PLoS ONE 6:e17347. 2011
    ..This study aimed to identify reference genes for clinical studies through microarray meta-analysis of human clinical samples...
  74. pmc Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans
    Genta Ohno
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS Genet 8:e1002991. 2012
    ....
  75. pmc The conserved transcriptome in human and rodent male gametogenesis
    Frederic Chalmel
    Biozentrum and Swiss Institute of Bioinformatics, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 104:8346-51. 2007
    ..Expression profiling data further identified numerous conserved genes of biological and clinical interest previously unassociated with the mammalian male germ line...
  76. ncbi An Arabidopsis T-DNA insertion mutant for galactokinase (AtGALK, At3g06580) hyperaccumulates free galactose and is insensitive to exogenous galactose
    Aurélie Egert
    Institute of Plant Biology, Molecular Plant Physiology, University of Zurich, Zollikerstrasse 107, Ch 8008 Zurich, Switzerland
    Plant Cell Physiol 53:921-9. 2012
    ..Collectively, these findings suggest a novel Gal detoxification pathway that targets free Gal to the vacuole and is active in the atgalk mutant background...
  77. pmc CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans
    Hidehito Kuroyanagi
    Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS Genet 9:e1003337. 2013
    ..Taken together, UNC-75 is the neuron-specific splicing factor and regulates both sets of the mutually exclusive exons of the unc-32 gene...
  78. pmc Poised RNA polymerase II changes over developmental time and prepares genes for future expression
    Bjoern Gaertner
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Cell Rep 2:1670-83. 2012
    ..We compare our data with findings in mammalian embryonic stem cells and discuss a framework for predicting developmental programs on the basis of the chromatin state...
  79. ncbi Insights into Populus XIP aquaporins: evolutionary expansion, protein functionality, and environmental regulation
    D Lopez
    Université Blaise Pascal UMRA 547 PIAF, Clermont Ferrand, France
    J Exp Bot 63:2217-30. 2012
    ..Unexpectedly, the PtXIPs displayed different abilities to alter water transport upon expression in Xenopus laevis oocytes. PtXIP2;1 and PtXIP3;3 transported water while other PtXIPs did not...
  80. pmc Construction of an oncolytic herpes simplex virus that precisely targets hepatocellular carcinoma cells
    Xinping Fu
    Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas 77204, USA
    Mol Ther 20:339-46. 2012
    ..Designated liver-cancer specific oncolytic virus (LCSOV), it was highly selective in killing HCC cells and in shrinking HCC xenografts. We conclude that LCSOV is a highly specific oncolytic virus that can precisely target HCC...
  81. pmc The glossyhead1 allele of ACC1 reveals a principal role for multidomain acetyl-coenzyme A carboxylase in the biosynthesis of cuticular waxes by Arabidopsis
    Shiyou Lü
    Center for Plant Stress Genomics and Technology, King Abdullah University of Science and Technology, Thuwal 23955 6900, Kingdom of Saudi Arabia
    Plant Physiol 157:1079-92. 2011
    ....
  82. pmc Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue
    Wei Xing
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:14210-5. 2011
    ..Furthermore, the CTMCs, which are constitutive, also show striking differences at these tissue sites, supporting the view that the differences in expression are tissue directed and not dependent on inflammation...
  83. pmc Functional integrative levels in the human interactome recapitulate organ organization
    Ouissem Souiai
    INSERM, U928, TAGC, Marseille, France
    PLoS ONE 6:e22051. 2011
    ..Given that several gradients have already been identified across interactomes, we propose that gradients may represent a general principle of protein-protein interaction network organization...
  84. ncbi Colorectal cancers choosing sides
    Cristina Albuquerque
    Centro de Investigacao de Patobiologia Molecular CIPM, Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Prof Lima Basto 1099 023 Lisboa, Portugal
    Biochim Biophys Acta 1816:219-31. 2011
    ..Combining this analysis with published data, we propose a mechanism underlying the side-related preferences of colorectal cancers, based on the specific acquired genetic defects in β-catenin signalling...
  85. pmc Identification of human housekeeping genes and tissue-selective genes by microarray meta-analysis
    Cheng Wei Chang
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    PLoS ONE 6:e22859. 2011
    ..Previous studies have been mainly based on a few data sets with limited samples in each tissue, which restrained the representativeness of their identified genes, and resulted in low consensus among them...
  86. ncbi Ancestral expression patterns and evolutionary diversification of YABBY genes in angiosperms
    Toshihiro Yamada
    Department of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    Plant J 67:26-36. 2011
    ..The expression data and phylogeny for YAB genes suggest that the ancestral YAB gene was expressed in proliferating tissues of lateral organs...
  87. pmc Differential expression of alpha 2 macroglobulin in response to dietylstilbestrol and in ovarian carcinomas in chickens
    Whasun Lim
    Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul 151 921, Korea
    Reprod Biol Endocrinol 9:137. 2011
    ..Therefore, we investigated estrogen regulation of A2M gene expression during development of the chicken oviduct, and its expression in normal and cancerous ovaries from chickens...
  88. pmc Exploring the transcriptome of ciliated cells using in silico dissection of human tissues
    Alexander E Ivliev
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    PLoS ONE 7:e35618. 2012
    ..Taken together, our large-scale analysis of gene coexpression networks identifies novel genes related to human cell cilia...
  89. pmc Overexpression of the epidermis-specific homeodomain-leucine zipper IV transcription factor Outer Cell Layer1 in maize identifies target genes involved in lipid metabolism and cuticle biosynthesis
    Marie Javelle
    Universite de Lyon, Ecole Normale Superieure de Lyon, Universite Lyon 1, Institut Fédératif de Recherche 128 BioSciences Lyon Gerland, Unité Reproduction et Développement des Plantes, F 69364 Lyon, France
    Plant Physiol 154:273-86. 2010
    ..Our data demonstrate that, in addition to AP2/EREBP and MYB-type transcription factors, members of the HD-ZIP IV family contribute to the transcriptional regulation of genes involved in cuticle biosynthesis...
  90. pmc Cell size is positively correlated between different tissues in passerine birds and amphibians, but not necessarily in mammals
    J Kozlowski
    Jagiellonian University, Institute of Environmental Sciences, Krakow, Poland
    Biol Lett 6:792-6. 2010
    ..We suggest that the assumptions in both models are not universal, and that such models need reformulation...
  91. ncbi Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS
    S Sakakibara
    Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Neurosci 21:8091-107. 2001
    ..These two RNA-binding proteins may exert common functions in neural precursor cells by regulating gene expression at the post-transcriptional level...
  92. pmc Effect of constitution on mass of individual organs and their association with metabolic rate in humans--a detailed view on allometric scaling
    Manfred J Muller
    Institut fur Humanernahrung und Lebensmittelkunde, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    PLoS ONE 6:e22732. 2011
    ..These data are the first evidence that constitution adds to the complexity of REE. Since organs scale differently as weight as well as height the "fit" of organ masses within constitution should be considered as a further trait...
  93. pmc Sequence and chromatin determinants of cell-type-specific transcription factor binding
    Aaron Arvey
    Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genome Res 22:1723-34. 2012
    ..Our results suggest that using a single motif for each TF and filtering for chromatin accessible loci is not always sufficient to accurately account for cell-type-specific binding profiles...
  94. pmc C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline
    Caroline Kumsta
    Program of Development and Aging, Sanford Burnham Medical Research Institute, Del E Webb Neuroscience, Aging and Stem Cell Research Center, La Jolla, California, United States of America
    PLoS ONE 7:e35428. 2012
    ....
  95. pmc The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14
    C Lloyd
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    J Cell Biol 129:1329-44. 1995
    ....
  96. pmc A comprehensive functional analysis of tissue specificity of human gene expression
    Zoltan Dezso
    GeneGo, Inc, Renaissance Drive, St, Joseph, MI 49085, USA
    BMC Biol 6:49. 2008
    ..We have performed a functional and topological analysis of housekeeping and tissue-specific networks to identify universally necessary biological processes, and those unique to or characteristic of particular tissues...
  97. ncbi Tissue-specific silencing of homoeologs in natural populations of the recent allopolyploid Tragopogon mirus
    Richard J A Buggs
    Department of Biology, University of Florida, Gainesville, FL 32611, USA
    New Phytol 186:175-83. 2010
    ..Our study shows that tissue-specific silencing, and even apparent subfunctionalization, can arise rapidly in the early generations of natural allopolyploidy...
  98. pmc Bioinformatic identification and characterization of human endothelial cell-restricted genes
    Manoj Bhasin
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    BMC Genomics 11:342. 2010
    ....
  99. pmc Genome-wide characterization of transcriptional start sites in humans by integrative transcriptome analysis
    Riu Yamashita
    Frontier Research Initiative, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genome Res 21:775-89. 2011
    ..The collected integrative information should provide a useful basis for future biological characterization of TSCs...
  100. ncbi When needles look like hay: how to find tissue-specific enhancers in model organism genomes
    Maximilian Haeussler
    U1126 MSNC INRA Group, UPR3294 NED, Institut Fessard, CNRS, Gif sur Yvette, France
    Dev Biol 350:239-54. 2011
    ..The review is accompanied by a list of general guidelines for such a project...
  101. pmc Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation
    Lieven Thorrez
    Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    Genome Res 21:95-105. 2011
    ..Together, we provide a systematic analysis of tissue-specific repression of housekeeping genes, a phenomenon that has not been studied so far on a genome-wide basis and, when perturbed, can lead to human disease...

Research Grants62

  1. PROFILING SYNOVIAL VASCULATURE IN ARTHRITIS-PRONE RATS
    KAMAL MOUDGIL; Fiscal Year: 2005
    ..abstract_text> ..
  2. Viral Gastroenteritis: Basis of Protection and Virulence
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    ..in vivo, which RV genes are responsible for the variation in systemic replication capacity and distinct organ specificity of different RV strains and investigate how the strain-dependent effects of NSP1 on IFN signaling affect ..
  3. IMAGING AUTOIMMUNE DISEASE
    Diane J Mathis; Fiscal Year: 2013
    ..The resulting cross-fertilization will almost certainly continue to result in novel solutions to the persisting problems posed by autoimmune disease. ..
  4. CBP Bromodomain Antagonists Block Androgen Receptor in Prostate Cancer
    SYED S MUJTABA; Fiscal Year: 2010
    ..Resultantly, AR remains a valuable therapeutic target due to this organ specificity. Although it is known that CBP/p300 (CREB binding protein) mediated lysine acetylation of AR (ARKac) plays a ..
  5. Functional Assays for Stress Biosensor Probes in the Nrf2-ARE System
    Shuji Kishi; Fiscal Year: 2013
    ..Validated chemical hits in the zebrafish embryo and larval screen can be further evaluated to determine organ specificity as the fish grow and for efficacy in preventing oxidative damage...
  6. Development of Novel Tools for Gene Targeting in Smooth Muscle
    Rosalyn M Adam; Fiscal Year: 2012
    ..We believe these additions to the genetic 'tool-kit'will greatly facilitate advancements in our understanding of SM biology. ..
  7. Bioengineering 3-D Models for Breast Cancer Therapy
    MINA JAHAN BISSELL; Fiscal Year: 2010
    ..Moreover, elucidating similarities and differences in breast and airway epithelium will facilitate discovery and design of novel tissue-specific therapies. ..
  8. Dendritic Block Copolymer Micelles as New Targeted Drug Delivery Systems
    Paula T Hammond; Fiscal Year: 2010
    ..with potential clinical interest, with a focus on pharmacokinetics, biodistribution as a function of time, organ specificity, accumulation of drug carriers, intratumor uptake, and tumor inhibition as well as cytotoxicity...
  9. MOLECULAR MECHANISMS OF ANTICARCINOGENESIS
    Thomas Kensler; Fiscal Year: 1991
    ..The effects of dietary antioxidants on: a) quantitative and qualitative patterns, organ specificity, and repair of aflatoxin-DNA adduct formation and removal, b) enzymologic basis for the altered balance ..
  10. ENDOTHELIAL GROWTH FACTOR IN PROSTATE CANCER METASTASIS
    Dan Theodorescu; Fiscal Year: 2005
    ..an important way which malignant cells employ to enhance their angiogenic potential and may explain the organ specificity of CaP metastasis...
  11. Vascular Targeting for Imaging and Treatment of Benign Prostatic Hyperplasia
    Michael Zwick; Fiscal Year: 2009
    ..validate by MR-imaging, both in vivo and ex vivo, and optical microscopic imaging of tissue specimens, the organ specificity and intra-organ distribution of the SPIO-StasixTM particles within the vascular network of the primary ..
  12. Biliary and Intestinal Cell Models of Drug Toxicity
    MARY KANZ; Fiscal Year: 2004
    ..Our specific aims are (1) validate the target organ specificity of biliary drug/ metabolites to BDC versus IEC in vitro by viability assays and functional indices of cell ..
  13. TRANSTHYRETIN DEPOSITION IN AGING TRANSGENIC MICE
    Joel Buxbaum; Fiscal Year: 2004
    ..This recapitulation of age, sex and target organ specificity, as is seen in humans, suggests that the transgenic model will be useful in allowing us to define the ..
  14. SPECIFICITY OF HUMAN AUTOANTIBODIES TO PROTEOGLYCANS
    Howard Fillit; Fiscal Year: 1992
    ..Finally, the investigators propose that cell-mediated immunity causes vascular injury via T-cell recognition of PHS sites which may differ from PHS epitopes recognized by autoantibody...
  15. CDX EXPRESSION IN THE GASTROINTESTINAL TRACT
    Debra Silberg; Fiscal Year: 1999
    ..and stomach in early embryogenesis or in weaned animals in order to further our understanding of some of the basic mechanisms involved in intestinal and gastric differentiation and the maintenance of organ specificity.
  16. Molecular Diversity in Bladder Cancer
    Wadih Arap; Fiscal Year: 2009
    ..Herein we propose to pursue candidate peptides with the ability to internalize into urothelial cells to develop therapeutic targeting strategies for the treatment of bladder cancer. ..
  17. The role of TOR in digestive tract development
    Alan Mayer; Fiscal Year: 2007
    ..to the digestive organs suggests that an additional common mechanism of control exists that provides organ specificity to the phenotype of these defects...
  18. FUNCTIONAL ROLE OF MULTIPLE THYROID HORMONE RECEPTORS
    RONALD KOENIG; Fiscal Year: 1991
    ..The objective of this proposal is to use the erb62 cDNA to rest the hypothesis that the organ specificity and developmental specificity of many T3 actions may be due to: a) differential expression of functionally ..
  19. EXTRACELLULAR MATRIX IN HEMATOPOIETIC MICROENVIRONMENT
    Michael Long; Fiscal Year: 1992
    ..This may have important implications in the understanding of disorders such a aplastic anemia, myelofibrosis, and leukemia...
  20. DEVELOPMENTAL GENETICS OF AN INDUCIBLE GENE SYSTEM
    Michael Freeling; Fiscal Year: 1990
    ..Further, we propose to apply our methods of cell immobilization, current microinjection (iontophoresis) and Mu1-vector construction to transforming maize cells in culture...
  21. DIFFERENTIAL ADHERENCE AND INVASION OF CELLS BY NOCARDIA
    Blaine Beaman; Fiscal Year: 2000
    ..involved in adherence to and invasion of host cells resulting in an understanding of mechanisms for organ specificity and dissemination. These studies should lead to improved diagnosis, treatment, and prevention of nocardiosis. ..
  22. Organ Specific Damage Assessment Biomarker Assays
    Thomas Brown; Fiscal Year: 2005
    ..The biomarkers evaluated to date in biological fluids with relatively non-invasive access generally lack organ specificity and are not sensitive enough to detect mild damage and/or damage that occurred in the past In Phase I we ..
  23. FACTORS INVOLVED IN MALIGNANT BEHAVIOR OF HUMAN TUMORS
    Liliana Ossowski; Fiscal Year: 2007
    ..will affect dormancy of cancer cells directly at the site of metastasis and whether uPAR contributes to organ specificity of metastases...
  24. Role of ADAMs in Heart Myocyte Development
    Wayne Carver; Fiscal Year: 2005
    ..These studies will elucidate the roles of members of this novel protein family in cardiomyocyte differentiation and organization in the developing heart. ..
  25. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..abstract_text> ..
  26. P53 AND DNA PLOIDY IN BARRETT'S METAPLASIA
    Mamoun Younes; Fiscal Year: 2005
    ..A cost analysis will be then performed to determine whether a molecular based surveillance program would be more cost-effective than current program which is based on morphologic grading of dysplasia. ..
  27. Estrogen Receptor-Selective Herbs for Menopause Symptoms
    Dale Leitman; Fiscal Year: 2006
    ..abstract_text> ..
  28. Leptin as a regular of bone mass
    Gerard Karsenty; Fiscal Year: 2010
    ..To determine, in vivo, the role of CREB as a transcriptional mediator of the leptin-dependent sympathetic regulation of bone mass. - To establish in vivo the role of c-myc as a mediator of the clock genes regulation of bone formation. ..
  29. COLLAGEN-ANNEXIN INTERACTIONS IN TISSUE MINERALIZATION
    Thorsten Kirsch; Fiscal Year: 2007
    ..abstract_text> ..
  30. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2005
    ..Evaluate the molecular mechanism by which NAC stimulates renal excretion of MeHg. IV. Test the hypothesis that urinary excretion of MeHg following an NAC oral challenge may be used as a new biomarker of MeHg exposure. ..
  31. Conference on Tumor Induction and Progression
    Mina Bissell; Fiscal Year: 2005
    ..We need to capture more brilliant minds to enter this area. In this first Keystone meeting on tumor microenvironment, we propose to unravel the excitement and the promise of the field. ..
  32. GENETIC ANALYSIS OF PSORIASIS
    Anne Bowcock; Fiscal Year: 2001
    ..When alterations are found, they will be screened for in 100 unrelated controls to determine the possibility of their contributing to the development of psoriasis. ..
  33. Effects of Tobacco Smoke on Airway Bactericidal Activity
    Yuan Pu Di; Fiscal Year: 2004
    ..Finally, the candidate may obtain a better understanding of the pathogenesis of bacterial infections in certain lung diseases under effects of tobacco smoke, and the development of new therapeutic strategies...
  34. REGULATION OF MINERALIZATION IN SKELETAL TISSUES
    Thorsten Kirsch; Fiscal Year: 2009
    ..Therefore, this proposal might provide a novel therapeutic target to prevent pathological mineralization. ..
  35. REGULATION OF ION CHANNELS BY APOPTOSIS TRIGGER PROTEINS
    Toshinori Hoshi; Fiscal Year: 2002
    ..abstract_text> ..
  36. Engineered Cell Lines for Regulatory Protein Analysis
    John Stamatoyannopoulos; Fiscal Year: 2004
    ..Fractionation over sucrose gradients has the added advantage of providing a clean reagent for downstream mass spectrometric studies. Such studies are envisioned to form the basis of a follow-on Phase II proposal. ..
  37. Tooth Eruption: Role of Dental Follicle & PTH Receptor
    Laurie McCauley; Fiscal Year: 2006
    ..Furthermore, these studies will enhance our basic knowledge as to the role of PTHrP and PTH-1R interactions in controlling mineralized tissue homeostasis. ..
  38. INTEGRATED ISOLATION & MOLECULAR ANALYSIS OF TUMOR CELLS
    Peter Gascoyne; Fiscal Year: 2003
    ..The technologies will then be tested and refined using clinically relevant samples. ..
  39. IMPROVED ALLOGRAFT HEART VALVE PRESERVATION
    Kelvin Brockbank; Fiscal Year: 2003
    ..It is anticipated that modification or reduction of ice formation in cryopreserved valves should decrease the need for reoperation due to structural deterioration and calcification in allograft recipients. ..
  40. In-Situ Sediment Remediation Using Benthic Waterjet Amendment Placement
    Joel G Burken; Fiscal Year: 2010
    ..This range of experiences and expertise is unique and will certainly help in making success in this research endeavor highly likely. ..
  41. CRYOPRESERVATION OF ARTICULAR CARTILAGE BY VITRIFICATION
    Kelvin Brockbank; Fiscal Year: 2003
    ..The U.S. market for cartilage repair products is predicted to exceed 90,000 units and $248 million in the near future. ..
  42. Sequenom MassARTRAY System
    Anne Bowcock; Fiscal Year: 2003
    ..At the end of the grant period it will be incorporated into a core genotyping facility within the Division of Human Genetics. ..
  43. Characterizing Mammalian Embryonic polyA Binding Protein
    Emre Seli; Fiscal Year: 2008
    ....
  44. THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    Jean Shih; Fiscal Year: 2008
    ..Co-regulators interacting with APJGR during agonist stimulated or basal state will be co-immuno-precipitated by AR or GR specific antibody. The validity and the function of identified protein(s) will be investigated. ..
  45. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
    ..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
  46. Genetic Risk Factors for Psoriasis
    Anne Bowcock; Fiscal Year: 2006
    ..Gene identification may be facilitated by the comprehensive gene expression data we have recently acquired in comparing involved and uninvolved psoriatic skin with normal skin. ..
  47. PEX7 AND IT'S ROLE IN THE PATHOGENESIS OF RCDP
    Nancy Braverman; Fiscal Year: 2005
    ..This information will contribute to understanding the pathophysiology of RCDP as well as the normal biology of peroxisome assembly and function in bone, lens and CNS development. ..
  48. TRANSCRIPTIONAL SILENCING MECHANISMS
    JEF BOEKE; Fiscal Year: 2005
    ..We will use the tools of molecular genetics, biochemistry and structural biology to carry out a comprehensive analysis of the molecular mechanisms involved in silencing. ..
  49. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2006
    ..abstract_text> ..
  50. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2007
    ..unreadable] [unreadable] These studies are important for both basic neuropharmacology and clinical[unreadable] research. ..
  51. Realistic Phantom Series for OLINDA/EXM Version 2
    Michael Stabin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  52. Commercial Feasibility Assessment of Pancreatic Islet Progenitor Cell Technology
    Kelvin Brockbank; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. Reconfigurable microfluidic assay platform for molecula*
    Peter Gascoyne; Fiscal Year: 2008
    ..The assay platform described in this proposal has the potential to accelerate the drug discovery process by enabling more efficient and cost-effective compound screening. ..
  54. Engineering and Analysis of T cell CD3 and IL2R Signals
    KARL WITTRUP; Fiscal Year: 2008
    ..These studies will provide insights into T cell regulation as well as develop CDS and IL-2 stimulatory molecules of potential therapeutic value. ..
  55. Vitamin D and Barrier Function
    Martin Hewison; Fiscal Year: 2008
    ..abstract_text> ..
  56. Biology and biochemistry of Jelly belly signaling
    Joseph Weiss; Fiscal Year: 2008
    ..Analysis of the phenotype of Ptn/Mk mutants in Drosophila will clarify the signaling function of these molecules both with respect to the pathways in which they participate and their functions in those pathways. [unreadable] [unreadable]..
  57. A Nucleosomal Biosensor for Identification and Isolation of Nuclear Hormone Recep
    Richard Steinman; Fiscal Year: 2008
    ..This biosensor should be more rapid and versatile than cell-based reporter gene assays and more informative than assays that measure only ligand/receptor binding. [unreadable] [unreadable] [unreadable]..
  58. Feasibility of Hypothermic Liver Perfusion
    Kelvin Brockbank; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..