antibody formation

Summary

Summary: The proliferation and differentiation of B-LYMPHOCYTES into PLASMA CELLS or memory cells. On stimulation by ANTIGENS, those cells then produce ANTIBODIES.

Top Publications

  1. pmc Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    Robert J Johnston
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology LIAI, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 325:1006-10. 2009
  2. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
  3. ncbi TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    T R Mosmann
    DNAX Research Institute, Palo Alto, California 94304
    Annu Rev Immunol 7:145-73. 1989
  4. ncbi Duration of humoral immunity to common viral and vaccine antigens
    Ian J Amanna
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    N Engl J Med 357:1903-15. 2007
  5. ncbi Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004
  6. pmc Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    D Breitfeld
    Molecular Tumor and Immunogenetics, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Exp Med 192:1545-52. 2000
  7. ncbi Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study
    David Goldblatt
    Immunobiology Unit, Institute of Child Health, University College London, UK
    J Infect Dis 192:387-93. 2005
  8. ncbi T follicular helper (TFH) cells in normal and dysregulated immune responses
    Cecile King
    Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Annu Rev Immunol 26:741-66. 2008
  9. pmc Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery
    D Huw Davies
    Center for Virus Research, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:547-52. 2005
  10. pmc Relationship between exposure to vector bites and antibody responses to mosquito salivary gland extracts
    Albin Fontaine
    Unite de Parasitologie, Antenne Marseille de l Institut de Recherche Biomédicale des Armées, Marseille, France
    PLoS ONE 6:e29107. 2011

Detail Information

Publications298 found, 100 shown here

  1. pmc Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    Robert J Johnston
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology LIAI, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 325:1006-10. 2009
    ..These findings demonstrate that T(FH) cells are required for proper B cell responses in vivo and that Bcl6 and Blimp-1 play central but opposing roles in T(FH) differentiation...
  2. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
    ..Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation...
  3. ncbi TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    T R Mosmann
    DNAX Research Institute, Palo Alto, California 94304
    Annu Rev Immunol 7:145-73. 1989
  4. ncbi Duration of humoral immunity to common viral and vaccine antigens
    Ian J Amanna
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    N Engl J Med 357:1903-15. 2007
    ..Maintenance of long-term antibody responses is critical for protective immunity against many pathogens. However, the duration of humoral immunity and the role played by memory B cells remain poorly defined...
  5. ncbi Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004
    ..Recent studies have provided important clues about the mechanisms of TLR-mediated control of adaptive immunity orchestrated by dendritic cell populations in distinct anatomical locations...
  6. pmc Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    D Breitfeld
    Molecular Tumor and Immunogenetics, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Exp Med 192:1545-52. 2000
    ..Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells "follicular B helper T cells" (T(FH))...
  7. ncbi Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study
    David Goldblatt
    Immunobiology Unit, Institute of Child Health, University College London, UK
    J Infect Dis 192:387-93. 2005
    ..pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S. pneumoniae have been conducted using sophisticated immunological laboratory techniques...
  8. ncbi T follicular helper (TFH) cells in normal and dysregulated immune responses
    Cecile King
    Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Annu Rev Immunol 26:741-66. 2008
    ..Consequently, dysregulation of T(FH) cell function, and over- or under-expression of T(FH) cell-associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies...
  9. pmc Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery
    D Huw Davies
    Center for Virus Research, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:547-52. 2005
    ..These results verify this platform as a rapid way to comprehensively scan humoral immunity from vaccinated or infected humans and animals...
  10. pmc Relationship between exposure to vector bites and antibody responses to mosquito salivary gland extracts
    Albin Fontaine
    Unite de Parasitologie, Antenne Marseille de l Institut de Recherche Biomédicale des Armées, Marseille, France
    PLoS ONE 6:e29107. 2011
    ..caspius density. Characterisation of such immunological-markers may allow the evaluation of the effectiveness of vector-control strategies or estimation of the risk of vector-borne disease transmission...
  11. ncbi Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    Nicholas Simpson
    Australian National University, Canberra, ACT, Australia
    Arthritis Rheum 62:234-44. 2010
    ..The purpose of this study was to examine the hypothesis that this pathway could account for a subset of patients with systemic lupus erythematosus (SLE)...
  12. ncbi Immunogenicity and safety in adults of one dose of influenza A H1N1v 2009 vaccine formulated with and without AS03A-adjuvant: preliminary report of an observer-blind, randomised trial
    Francois Roman
    GlaxoSmithKline Biologicals, Avenue Fleming 20, 1300 Wavre, Belgium
    Vaccine 28:1740-5. 2010
    ....
  13. ncbi BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
    Felix M Wensveen
    Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Blood 119:1440-9. 2012
    ..Manipulation of this process may alter the breadth of antibody responses after immunization...
  14. pmc Rapid evolution of the neutralizing antibody response to HIV type 1 infection
    Douglas D Richman
    Department of Pathology, Veterans Affairs San Diego Healthcare System and the University of California at San Diego, La Jolla, CA 92093 0679, USA
    Proc Natl Acad Sci U S A 100:4144-9. 2003
    ..These data argue that neutralizing antibody responses account for the extensive variation in the envelope gene that is observed in the early months after primary HIV infection...
  15. pmc Cytokine-secreting follicular T cells shape the antibody repertoire
    R Lee Reinhardt
    Howard Hughes Medical Institute and Departments of Medicine and Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:385-93. 2009
    ..Our findings support a model in which B cells compete for cytokines produced by follicular helper T cells that shape the affinity and isotype of the antibody response...
  16. ncbi Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL
    Micah J Benson
    Department of Microbiology and Immunology, Dartmouth Medical School, The Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Immunol 180:3655-9. 2008
    ..These data define the BAFF/APRIL-dependent and -independent components of long-lived humoral immunity...
  17. pmc Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response
    Cristina L Swanson
    Integrated Department of Immunology, University of Colorado, Denver, CO 80206, USA
    J Exp Med 207:1485-500. 2010
    ..Thus, innate signals have the capacity to enhance TI-2 antibody responses by promoting participation of FO B cells, which then elaborate effective IgG anti-pathogen antibodies...
  18. pmc Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses
    Steven G Deeks
    Department of Medicine, University of California at San Francisco, San Francisco General Hospital, CA 94110, USA
    J Virol 80:6155-64. 2006
    ..These observations also suggest that the neutralizing antibody response may contribute to the long-term control of HIV in some patients while protecting against HIV superinfection in most patients...
  19. pmc B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    Danielle T Avery
    Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    J Exp Med 207:155-71. 2010
    ..STAT3-activating cytokines such as IL-21 thus underpin Ag-specific humoral immune responses and provide a mechanism for the functional antibody deficit in STAT3-deficient patients...
  20. pmc T follicular helper cells differentiate from Th2 cells in response to helminth antigens
    Arielle Glatman Zaretsky
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 206:991-9. 2009
    ..The relationship of TFH cells to the Th2 lineage was confirmed when TFH cells were found to develop from CXCR5(-) PD-1(-) IL-4/GFP(+) CD4(+) T cells after their transfer into naive mice and antigen challenge in vivo...
  21. ncbi Role of BCR affinity in T cell dependent antibody responses in vivo
    Tien An Yang Shih
    Laboratory of Molecular Immunology, The Rockefeller University New York, NY 10021, USA
    Nat Immunol 3:570-5. 2002
    ..We conclude that in addition to the selection that occurs in GCs, stringent selection for high-affinity clones is also imposed in the early stages of the T cell dependent immune response in vivo...
  22. pmc IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    Irah L King
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 206:1001-7. 2009
    ..Our report reveals the compartmentalization of Th2 priming and IL-4 production in the lymph nodes during infection, and identifies Tfh cells as the dominant source of IL-4 in vivo...
  23. ncbi Aging affects human B cell responses
    Daniela Frasca
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, RMSB 3146A, P O Box 016960 R 138, Miami, FL 33101, USA
    J Clin Immunol 31:430-5. 2011
    ..We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine...
  24. ncbi Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 450:110-4. 2007
    ....
  25. pmc Antibody responses of domestic animals to salivary antigens of Triatomainfestans as biomarkers for low-level infestation of triatomines
    Alexandra Schwarz
    School of Biological Sciences, Zoology Building, University of Aberdeen, Aberdeen, UK
    Int J Parasitol 39:1021-9. 2009
    ..These represent promising epidemiological markers for the detection of small numbers of feeding bugs and hence may be a new tool for vector surveillance in Chagas disease control programs...
  26. ncbi Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: results from the Liraglutide Effect and Action in Diabetes (LEAD) trials
    John B Buse
    Division of Endocrinology, University of North Carolina School of Medicine, CB 7172, 8027 Burnett Womack Building, Chapel Hill, North Carolina 27599, USA
    J Clin Endocrinol Metab 96:1695-702. 2011
    ..Therapeutic proteins/peptides can produce immunogenic responses that may increase the risk of adverse events or reduce efficacy...
  27. ncbi Maintenance of serological memory by polyclonal activation of human memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Science 298:2199-202. 2002
    ..Although antigen boosting leads to a transient increase in specific antibody levels, ongoing polyclonal activation of memory B cells offers a means to maintain serological memory for a human lifetime...
  28. pmc Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands
    J Exp Med 205:869-82. 2008
    ..These findings suggest that alum adjuvant is immunogenic by exploiting "nature's adjuvant," the inflammatory DC through induction of the endogenous danger signal uric acid...
  29. ncbi Defective B cell development and function in Btk-deficient mice
    W N Khan
    Howard Hughes Medical Institute, Childrens Hospital, Boston, Massachusetts 02115, USA
    Immunity 3:283-99. 1995
    ..These results prove that lack of Btk function results in an Xid phenotype and further suggest a differential requirement for Btk during the early stages of murine versus human B lymphocyte development...
  30. pmc Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced
    Joseph M Dal Porto
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Exp Med 195:1215-21. 2002
    ..The failure to observe such B cells normally in late primary responses and in memory B cell populations is the result of competition, rather than an intrinsic inability of low affinity B cells...
  31. ncbi The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation
    T Kawabe
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Immunity 1:167-78. 1994
    ..These results suggest that CD40 is essential for T cell-dependent immunoglobulin class switching and germinal center formation, but not for in vivo T cell-dependent IgM responses and T cell-independent antibody responses...
  32. pmc Batf coordinates multiple aspects of B and T cell function required for normal antibody responses
    Briana C Betz
    Department of Biological Sciences, Purdue University West Lafayette, IN 47907, USA
    J Exp Med 207:933-42. 2010
    ..We conclude that loss of Batf disrupts multiple components of the lymphocyte communication network that are required for a robust immune response...
  33. ncbi Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation
    Deepta Bhattacharya
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 179:6808-19. 2007
    ....
  34. ncbi Plasma cell differentiation requires the transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 412:300-7. 2001
    ..XBP-1 is the only transcription factor known to be selectively and specifically required for the terminal differentiation of B lymphocytes to plasma cells...
  35. pmc Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 202:321-31. 2005
    ..These results demonstrate a specific requirement for TLR9 in autoantibody formation in vivo and indicate a critical role for innate immune activation in autoimmunity...
  36. pmc Human antibody responses to the Anopheles salivary gSG6-P1 peptide: a novel tool for evaluating the efficacy of ITNs in malaria vector control
    Papa Makhtar Drame
    UR016 Contrôle et Caractérisation des Populations de Vecteurs, Institut de Recherche pour le Developpement, Cotonou, Benin
    PLoS ONE 5:e15596. 2010
    ....
  37. pmc Germinal-center organization and cellular dynamics
    Christopher D C Allen
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Immunity 27:190-202. 2007
    ....
  38. ncbi Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity
    James W Huleatt
    VaxInnate Corporation, New Haven, CT 06511, USA
    Vaccine 25:763-75. 2007
    ..Collectively our data demonstrate that PAMP:antigen fusion proteins offer significant promise for developing recombinant protein vaccines...
  39. pmc Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine
    Suresh Pallikkuth
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Blood 120:985-93. 2012
    ..Characterization of pTFH cells may provide additional insight into cellular determinants of vaccine-induced Ab response, which may have relevance for vaccine design...
  40. pmc Enhanced breadth of CD4 T-cell immunity by DNA prime and adenovirus boost immunization to human immunodeficiency virus Env and Gag immunogens
    Lan Wu
    Vaccine Research Center, NIAID, National Institutes of Health, Room 4502, Bldg 40, MSC 3005, 40 Convent Drive, Bethesda, MD 20892 3005, USA
    J Virol 79:8024-31. 2005
    ..These findings suggest that the diversity of the CD4 immune response is increased by DNA/ADV prime-boost vaccination and that these components work synergistically to enhance T-cell epitope recognition...
  41. pmc Reduced antibody responses to the pandemic (H1N1) 2009 vaccine after recent seasonal influenza vaccination
    Yoon Seok Choi
    Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, 335 Gwahangno, Daejeon, Republic of Korea 305 701
    Clin Vaccine Immunol 18:1519-23. 2011
    ..Our finding should be taken into account for future vaccination programs against pandemic influenza virus outbreaks...
  42. pmc Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine
    Lissette S Velasquez
    Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, PO Box 875001, Tempe, AZ 85287 5001, USA
    Vaccine 29:5221-31. 2011
    ..We conclude that in situ gelation of the GelVac dry powder formulation at nasal mucosal surfaces delays mucociliary clearance and thereby prolongs VLP antigen exposure to immune effector sites...
  43. ncbi Plasma cells require autophagy for sustainable immunoglobulin production
    Niccolò Pengo
    Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy
    Nat Immunol 14:298-305. 2013
    ..Thus, autophagy is specifically required for plasma cell homeostasis and long-lived humoral immunity...
  44. pmc Cellular and humoral immunity are synergistic in protection against types A and B Francisella tularensis
    Shite Sebastian
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Vaccine 27:597-605. 2009
    ..tularensis and provide important insight into the development of a safer vaccine effective against infections caused by clinical type A and B strains of F. tularensis...
  45. ncbi Oral intake of Lactobacillus fermentum CECT5716 enhances the effects of influenza vaccination
    Monica Olivares
    Immunology and Animal Science Department, Puleva Biotech S A, Granada, Spain
    Nutrition 23:254-60. 2007
    ..We studied the coadjuvant capability of oral consumption of the breast-milk-isolated strain Lactobacillus fermentum (CECT5716) for an anti-influenza vaccine...
  46. ncbi Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers
    S Han
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Immunol 155:556-67. 1995
    ..Once B cells have entered the differentiation pathway to Ab production, neither CD40L nor B7-2 is necessary for their continued differentiation and persistence...
  47. ncbi Major role of local immune responses in antibody formation to factor IX in AAV gene transfer
    L Wang
    Department of Pediatrics, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Gene Ther 12:1453-64. 2005
    ..IX. In summary, the data document substantial influence of target tissue, local antigen presentation, and antigen levels on lymphocyte responses to F.IX...
  48. pmc Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele
    Ashlesh K Murthy
    Department of Biology, University of Texas at San Antonio, 6900 North Loop 1604 West, San Antonio, TX 78249, USA
    Infect Immun 74:6722-9. 2006
    ....
  49. pmc A conserved multi-gene family induces cross-reactive antibodies effective in defense against Plasmodium falciparum
    Subhash Singh
    Bio medical Parasitology Unit, Institut Pasteur, Paris, France
    PLoS ONE 4:e5410. 2009
    ..Both MSP3 and MSP6 share a common characteristic small N-terminal signature amino-acid stretch (NLRNA/G), a feature similar to MSP3-like orthologs identified in other human and primate malaria parasites...
  50. ncbi Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses
    Steven M Jones
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    Nat Med 11:786-90. 2005
    ..No evidence of EBOV or MARV replication was detected in any of the protected animals after challenge. Our data suggest that these vaccine candidates are safe and highly efficacious in a relevant animal model...
  51. pmc Evaluation of the human IgG antibody response to Aedes albopictus saliva as a new specific biomarker of exposure to vector bites
    Souleymane Doucoure
    Laboratoire Maladies Infectieuses et Vecteurs Écologie, Genetique, Evolution et Contrôle, UMR 224 CNRS IRD UM1, Montpellier, France
    PLoS Negl Trop Dis 6:e1487. 2012
    ..Human antibody (Ab) responses to mosquito salivary proteins could represent a reliable biomarker for evaluating human-vector contact and the efficacy of control programs...
  52. ncbi B-1 cells: the lineage question revisited
    L A Herzenberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Immunol Rev 175:9-22. 2000
    ....
  53. ncbi Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice
    Irina Caminschi
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Mol Immunol 50:9-17. 2012
    ..However in normal mice most MHC II presentation of the Clec9A-targeted antigen was by the major CD8(+) DC population, the DC also responsible for presentation on MHC I...
  54. pmc Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA
    Vera V Pinto
    Department of International Health, Immunology and Microbiology, University of Copenhagen, Centre for Medical Parasitology, Copenhagen, Denmark
    PLoS ONE 6:e17942. 2011
    ..Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta...
  55. pmc Horizontal transmission of Candida albicans and evidence of a vaccine response in mice colonized with the fungus
    Jim E Cutler
    Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e22030. 2011
    ....
  56. pmc Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses
    Silvia B Boscardin
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:599-606. 2006
    ..We conclude that antigen targeting to DCs combined with a maturation stimulus produces broad-based and long-lived T cell help for humoral immune responses...
  57. pmc Immunodominance and functional activities of antibody responses to inactivated West Nile virus and recombinant subunit vaccines in mice
    Juergen Zlatkovic
    Department of Virology, Medical University of Vienna, A 1095 Vienna, Austria
    J Virol 85:1994-2003. 2011
    ..Despite its low potency for priming, DIII was an excellent boosting antigen, suggesting novel vaccination strategies that strengthen and focus the antibody response to critical neutralizing sites in DIII...
  58. ncbi Mice deficient for the CD40 ligand
    J Xu
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510
    Immunity 1:423-31. 1994
    ..In summary, our study confirms the important role of CD40-CD40L interactions in thymus-dependent humoral immune responses and germinal center formation...
  59. ncbi IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...
  60. ncbi IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells
    Nicolle H R Litjens
    Department of Internal Medicine, Division of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 181:3665-73. 2008
    ..Based on these findings, we conclude that the development of Ag-specific IL-2-producing memory T cells appears to be essential for the development of IgG-secreting plasma cells in humans...
  61. ncbi Impact of prior or concomitant seasonal influenza vaccination on MF59-adjuvanted H1N1v vaccine (Focetria) in adult and elderly subjects
    R Gasparini
    Department of Health Sciences, Genoa University, Genoa, Italy
    Int J Clin Pract 64:432-8. 2010
    ..We investigated prior seasonal vaccination in adult and elderly subjects, and concomitant vaccination with seasonal vaccine in adults, on the tolerability and immunogenicity of the Novartis MF59-adjuvanted H1N1v vaccine, Focetria...
  62. pmc Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses
    Rhonda M Curran
    The School of Pharmacy, The Queen s University of Belfast, Belfast, BT9 7BL, Northern Ireland, UK
    Vaccine 27:6791-8. 2009
    ..Vaginal administration to rabbits induced specific serum IgG, and IgG and IgA in genital tract secretions. The RSVs are a viable delivery modality for vaginal immunization...
  63. ncbi Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level
    Evelien M Bunnik
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Med 16:995-7. 2010
    ..The enhanced neutralization resistance of HIV-1 in contemporary seroconverters coincided with the poorer elicitation of neutralizing antibody responses, which may have implications for vaccine design...
  64. ncbi A single immunization with a minute dose of a lentiviral vector-based vaccine is highly effective at eliciting protective humoral immunity against West Nile virus
    Maria Candela Iglesias
    Groupe de Virologie Moléculaire et Vectorologie, Institut Pasteur, 28 rue du Dr Roux 75724 Paris Cedex 15, France
    J Gene Med 8:265-74. 2006
    ..WNV is a mosquito-borne flavivirus that emerged in North America and causes encephalitis in humans, birds and horses. Neutralizing anti-WNV antibodies have been shown to be crucial for protection against WNV encephalitis...
  65. pmc Discordant memory B cell and circulating anti-Env antibody responses in HIV-1 infection
    Yongjun Guan
    Division of Basic Science, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 106:3952-7. 2009
    ..These data suggest that plasma Ab repertoires can underestimate the breadth of humoral immunity, and analyses of B(Mem) should be included in studies correlating Ab specificity with protective immunity to HIV-1...
  66. ncbi The immunogenicity, safety, and efficacy of etanercept liquid administered once weekly in patients with rheumatoid arthritis
    R K Dore
    Robin K Dore, MD, Inc, Anaheim, CA 92801, USA
    Clin Exp Rheumatol 25:40-6. 2007
    ..To evaluate the immunogenicity, safety, and efficacy of 50 mg/mL liquid etanercept...
  67. pmc Th2-associated local reactions to the acellular diphtheria-tetanus-pertussis vaccine in 4- to 6-year-old children
    Julie Rowe
    Division of Cell Biology, Telethon Institute for Child Health Research, P O Box 855, West Perth WA 6872, Australia
    Infect Immun 73:8130-5. 2005
    ..The time course of these reactions suggests that the underlying mechanism involves reactivation of Th2-polarized cellular immune memory...
  68. pmc Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria
    Menna R Clatworthy
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 104:7169-74. 2007
    ....
  69. ncbi Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
    Floris A van Gaalen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:2113-21. 2004
    ..We undertook this study to investigate the relationship between HLA class II gene polymorphisms and RA-specific IgG antibodies against cyclic citrullinated peptides (anti-CCP antibodies)...
  70. ncbi Adjuvants and antibody production: dispelling the myths associated with Freund's complete and other adjuvants
    Harold F Stills
    Laboratory Animal Resources, School of Medicine, Wright State University, Dayton, OH, USA
    ILAR J 46:280-93. 2005
    ..In cases where the antigen is a weak immunogen or has a very limited availability, the type and role of adjuvant becomes a critical component in producing an acceptable immune response and humoral antibody response...
  71. ncbi A reappraisal of humoral immunity based on mechanisms of antibody-mediated protection against intracellular pathogens
    Arturo Casadevall
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefoire Medical Center, Bronx, New York, USA
    Adv Immunol 91:1-44. 2006
    ..Consequently, far from being understood, recent findings in AMI imply a system with unfathomable complexity and the field is poised for a long overdue renaissance...
  72. ncbi Boosting antibody responses by targeting antigens to dendritic cells
    Irina Caminschi
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    Trends Immunol 33:71-7. 2012
    ..Few other cells absorb the antigen-antibody construct, therefore, it persists in the bloodstream, allowing sustained antigen presentation, even by non-activated DCs...
  73. ncbi Vaccines: correlates of vaccine-induced immunity
    Stanley A Plotkin
    Sanofi Pasteur, Doylestown, Pennsylvania, USA
    Clin Infect Dis 47:401-9. 2008
    ..In situations where the true correlate of protection is unknown or difficult to measure, surrogate tests (usually antibody measurements) must suffice as predictors of protection by vaccines. Examples of each circumstance are given...
  74. pmc Influenza virus evades innate and adaptive immunity via the NS1 protein
    Ana Fernandez-Sesma
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 80:6295-304. 2006
    ..Our observations also support the potential use of NS1 mutant influenza viruses as live attenuated influenza virus vaccines...
  75. ncbi Function of mucosa-associated lymphoid tissue in antibody formation
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation, University of Oslo, Department and Institute of Pathology, Oslo University Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Immunol Invest 39:303-55. 2010
    ....
  76. pmc Antibody responses after intravaginal immunisation with trimeric HIV-1 CN54 clade C gp140 in Carbopol gel are augmented by systemic priming or boosting with an adjuvanted formulation
    Martin P Cranage
    Centre for Infection and Immunity, Division of Clinical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Vaccine 29:1421-30. 2011
    ..Virus neutralising activity was detected against clade C and clade B HIV-1 envelopes but was restricted to highly neutralisation sensitive pseudoviruses...
  77. ncbi B cell repertoire and ageing
    Deborah K Dunn-Walters
    Department of Immunobiology, King s College London School of Medicine, Guy s Campus, London SE1 9RT, UK
    Curr Opin Immunol 22:514-20. 2010
    ....
  78. ncbi Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection
    James F Cummings
    Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Vaccine 28:5135-44. 2010
    ....
  79. ncbi A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 27:1889-97. 2009
    ..In conclusion, our study shows that producing effective H7 pandemic vaccines is as challenging as has been observed for H5 vaccines...
  80. ncbi Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity
    Tomofumi Uto
    Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    J Immunol 178:2979-86. 2007
    ..These results suggest that Ag-carrying gamma-PGA NPs are capable of inducing strong cellular and humoral immune responses and might be potentially useful as effective vaccine adjuvants for the therapy of infectious diseases...
  81. pmc Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells
    Yoonkyung Do
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York 10065 6399, USA
    Eur J Immunol 38:20-9. 2008
    ..This study sets the stage for the analysis of functional roles of IFN-gamma-producing T cells in Y. pestis infection...
  82. ncbi Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
    Barton F Haynes
    Duke University Medical Center, Durham, NC 27710, USA
    Expert Rev Vaccines 5:579-95. 2006
    ....
  83. pmc Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease
    Baodong Sun
    Department of Pediatrics, Division of Medical Genetics, Duke University Medical Center, Durham, North Carolina, USA
    Mol Ther 18:353-60. 2010
    ..01; symptoms: P < 0.05). Ubiquitous GAA expression failed to prevent antibody formation. Thus, immunomodulatory gene therapy could provide adjunctive therapy in lysosomal storage disorders treated ..
  84. ncbi The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses
    Mireille H Lahoud
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 182:7587-94. 2009
    ..The potent Ab responses induced using microgram amounts of anti-Clec12A and minimal amounts of adjuvant demonstrate that this molecule can be used as an Ag-delivery target to enhance Ab responses to vaccines...
  85. pmc Effects of protein aggregates: an immunologic perspective
    Amy S Rosenberg
    Food and Drug Administration, Center for Drug Evaluation and Research, Building 29A, Room 2D 16, 8800 Rockville Pike, Bethesda, MD 20892, USA
    AAPS J 8:E501-7. 2006
    ....
  86. pmc Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization
    Tera L McCool
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    Infect Immun 72:5807-13. 2004
    ..These results demonstrate that antibody is not required for clearance of pneumococcal colonization in mice...
  87. pmc Phase 1 study of a combination AMA1 blood stage malaria vaccine in Malian children
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali
    PLoS ONE 3:e1563. 2008
    ..The aim of this study was to assess the safety and immunogenicity of this vaccine in young children in a malaria endemic area...
  88. pmc Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine
    Paul E Makidon
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e2954. 2008
    ..A new nasal hepatitis B vaccine composed of recombinant hepatitis B surface antigen (HBsAg) in a novel nanoemulsion (NE) adjuvant (HBsAg-NE) could be effective with fewer administrations...
  89. ncbi Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    F Kontgen
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Genes Dev 9:1965-77. 1995
    ..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
  90. pmc Repeated vaginal administration of trimeric HIV-1 clade C gp140 induces serum and mucosal antibody responses
    M P Cranage
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s University of London, London, UK
    Mucosal Immunol 3:57-68. 2010
    ..Our data prove the concept that repeated exposure of the female genital tract to HIV envelope can induce mucosally detectable antibody...
  91. pmc Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid
    David H Cribbs
    Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, USA
    Int Immunol 15:505-14. 2003
    ....
  92. ncbi Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design
    Juliana Bessa
    Cytos Biotechnology AG, Zurich Schlieren, Switzerland
    Eur J Immunol 38:114-26. 2008
    ..Taken together, these results suggest that effective antibody-based vaccines are achievable by i.n. administration of Qbeta-VLP displaying specific antigens...
  93. pmc Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses
    Sheri M Eaton
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    J Exp Med 200:1613-22. 2004
    ..Our results show that, in this model, age-related reductions in the cognate helper function of CD4 T cells contribute significantly to defects in humoral responses observed in aged individuals...
  94. ncbi Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help
    Svenja Hardtke
    Institute of Immunology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Blood 106:1924-31. 2005
    ..Thus, we demonstrate that the balanced expression of CCR7 and CXCR5 determines the positioning and proper function of follicular T helper cells...
  95. ncbi Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly
    Donna M Murasko
    Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine and Public Health, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Exp Gerontol 37:427-39. 2002
    ..This suggests that cell-mediated responses play a significant role in protection in at least a subset of elderly from influenza disease after immunization...
  96. pmc Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant
    Sylvia Adams
    Department of Medicine, Division of Medical Oncology, New York University Cancer Institute, School of Medicine, New York, NY 10016, USA
    J Immunol 181:776-84. 2008
    ..Imiquimod's adjuvant effects require further evaluation and likely need optimization of parameters such as formulation, dose, and timing relative to Ag exposure for maximal immunogenicity...
  97. pmc Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay
    Carmen Fernandez-Becerra
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Rosello 132, 08036 Barcelona, Spain
    Malar J 9:29. 2010
    ....
  98. pmc Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid
    Stefan Worgall
    Department of Pediatrics, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 115:1281-9. 2005
    ....
  99. ncbi CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles
    Maire F Quigley
    Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur J Immunol 37:3352-62. 2007
    ..The finding that a subset of early effector memory CD8 T cells use CXCR5 to locate to B cell follicles indicates that MHC class I-restricted CD8 T cells are part of the follicular T cell population...
  100. ncbi BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle
    R Baxter
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Roslin Biocentre, Midlothian, EH25 9PS, United Kingdom
    Vaccine 28:28-37. 2009
    ....
  101. ncbi Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria
    Maarten L van Roosmalen
    BiOMaDe Technology Foundation, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Methods 38:144-9. 2006
    ..The GEM-based vaccines do not require additional adjuvant for eliciting high levels of specific antibodies in mucosal and systemic compartments...

Research Grants63

  1. Novel Biomarkers Predictive of Heparin-Induced Thrombocytopenia
    Barbara A Konkle; Fiscal Year: 2010
    ..We hypothesize that a constellation of biomarkers and clinical factors will predict risk of heparin/PF4 antibody formation and HIT, and propose studies to evaluate this through Specific Aims: 1) To determine if novel platelet ..
  2. Immune Tolerance in Non-clonal Immune Systems
    David Nemazee; Fiscal Year: 2013
    ..this natural mutation process can lead to self reactivity, it is important to understand how self reactive antibody formation is avoided...
  3. In vivo lentiviral transduction of bone marrow cells for hemophilia gene therapy
    Carol H Miao; Fiscal Year: 2013
    ..therapy treatment that can achieve long-term phenotypic correction without the complication of anti-FVIII antibody formation is highly desired...
  4. Oral Therapy for Hemophilia A
    Kam W Leong; Fiscal Year: 2013
    ..to i) determine the ability of nanoparticle-based oral gene therapy to correct coagulation and suppress antibody formation to F.VIII in murine models of hemophilia;ii) generate F...
  5. Induction of Tolerance to Factor VIII in Hemophilia
    DAVID WILLIAM SCOTT; Fiscal Year: 2012
    ..Our goal is to develop and translate a novel gene therapy protocol which reverses this antibody formation by inducing tolerance to therapeutic factor VIII.
  6. Blocking the immune response to Helper-dependent adenovirus vector for Hemophilia
    Masataka Suzuki; Fiscal Year: 2011
    ..However, because of high cost, access to therapy, and inhibitory antibody formation, patients continue to suffer from significant long-term morbidity and mortality...
  7. Preclinical &Phase I/II Trials of AAV-AAT Vectors
    Terence R Flotte; Fiscal Year: 2013
    ..responses by measuring ELISPOT responses to AAV9 capsid proteins and to AAT transgene product as well as antibody formation against rAAV9 capsid...
  8. Development of a Highly Sensitive Cell-Based Assay for Botulinum Neurotoxin
    Eric A Johnson; Fiscal Year: 2010
    ..Currently, patients are not routinely monitored for antibody formation during their treatment regime since a sensitive assay that measures antibodies in human sera (and in other ..
  9. Blocking the immune response to HDAd for Hemophilia A gene therapy
    Masataka Suzuki; Fiscal Year: 2013
    ..However, because of high cost, access to therapy, and inhibitory antibody formation, patients continue to suffer from significant long-term morbidity and mortality...
  10. In vivo function and tolerance to Factor VIII variants
    BRENDAN HL LEE; Fiscal Year: 2011
    ..However, because of high cost, access to therapy, and inhibitory antibody formation, patients continue to suffer from significant long-term morbidity and mortality...
  11. Entry of antigen-presenting B cells into the follicle directed by IFNa and IL-17
    Hui Chen Hsu; Fiscal Year: 2013
    ..mediators in the secondary lymphoid organ facilitates specialized B cells that transport antigens into the antibody formation area called germinal centers in autoimmune BXD2 mice...
  12. Epitope-driven deimmunization of Factor VIII
    ANNE SEARLS DE GROOT; Fiscal Year: 2010
    ..Neutralizing antibody formation, the root cause of FVIII therapy failure, is a process dependent on antigen presenting cell signaling to ..
  13. An Autoimmune Basis for Pulmonary Hypertension.
    Mark Nicolls; Fiscal Year: 2009
    ..of this Aim will be to demonstrate that protection from PH correlates with prevention of anti-endothelial antibody formation. Specific Aim II will be to determine whether spleen cell protection of VEGFR blockade-induced PH in athymic ..
  14. Clinical Significance of protamine/heparin antibodies after CPB
    Gowthami M Arepally; Fiscal Year: 2012
    ..Preliminary data obtained from this R21 funded study will allow us to document the clinical relevance of PRT/H Antibodies in CPB and enable future prospective investigations of outcomes related to antibody formation.
  15. Improving Efficacy of RNase Cancer Therapy by Pharmacokinetics
    Laura E Strong; Fiscal Year: 2010
    ..for the Phase II grant include: determination of the optimal schedule, a dose response and comparison of antibody formation to an unmodified EVade Ribonuclease...
  16. BIOLOGIC AND IMMUNOLOGIC ASPECTS OF TRANSFUSION MEDICINE
    Sherrill Slichter; Fiscal Year: 2009
    ..S. Pratt and Thompson's project addresses issues related to the prevention or reversal of inhibitor antibody formation in patients with acquired or congenital hemophilia A...
  17. Restoration of Dopaminergic Function in Parkinson's Disease
    Greg Gerhardt; Fiscal Year: 2009
    ..in PD patients involving a Phase 2 clinical trial have yielded controversial data regarding potential GDNF antibody formation and preliminary toxicology studies in rhesus monkeys support a potential toxicity of GDNF to cerebellar ..
  18. Immune Mechanisms in Heparin-Induced Thrombocytopenia/T*
    Michael Reilly; Fiscal Year: 2004
    ..platelet activation and thrombosis, and a model to study how an exogenous molecule (heparin) induces antibody formation against a self protein (platelet factor 4; PF4)...
  19. CHILDHOOD VACCINES AND DENTAL CARIES IMMUNITY
    Daniel Smith; Fiscal Year: 2007
    ..gland[unreadable] tissue to function as inductive sites for potentially caries-protective[unreadable] antibody formation within the oral cavity...
  20. Diphtheria fusion protein therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..If successful, such measures may be tested in patients. In Specific Aim 2, anti- DT388GMCSF antibody formation and DT388GMCSF serum levels will continue to be measured and correlated with toxicity and response...
  21. ROLE OF A-INTERFERON RECEPTOR IN HUMAN IMMUNOREGULATION
    Sharon Evans; Fiscal Year: 1992
    ..the plasma membrane and subcellular level and to determine the effect of other lymphokines, known to effect antibody formation, on the expression of IFN receptors...
  22. FORMATION, STORAGE, AND RELEASE OF GASTRIC ACID
    E Ekblad; Fiscal Year: 1990
    ..Immunocytochemical electron microscopy will be used to visualize acidic intracellular compartments using DAMP, monoclonal antibodies directed towards DAMP and gold conjugated IgG as the second antibody...
  23. HUMAN HYBRIDOMAS IN THE ANALYSIS OF AUTOIMMUNE DISEASE
    BERNARD STOLLAR; Fiscal Year: 1990
    ..In addition, the hypothesis that auto-anti-idiotype antibody formation is important in these responses will be tested. B...
  24. PATHOPHYSIOLOGY OF ANTIPHOSPHOLIPID ANTIBODY SYNDROMES
    Thomas Ortel; Fiscal Year: 2003
    ..with a familial form of the antiphospholipid antibody syndrome, confirming an inherited tendency to antibody formation. In these patients, autoantibodies that bind to proteins involved in normal hemostasis (e.g...
  25. Jo-1-specific T Cell Responses in Polymyositis
    DANA ASCHERMAN; Fiscal Year: 2007
    ..of this proposal is that antigen-specific T cell responses directed against Jo-1 promote anti-Jo-1 antibody formation as well as T cell-mediated cytolysis/dysfunction of muscle cells in Jo-1+ polymyositis...
  26. LIPOPROTEINS IN BIOREGULATION OF THE IMMUNE RESPONSE
    Jane Morse; Fiscal Year: 1980
    ..including T and B cell rosette formation, the production of leucocyte migration inhibitory factor, antibody formation to T dependent and T independent antigens; the graft versus host reaction and the homograft reaction...
  27. STRUCTURAL STUDIES OF UNIQUE MYELOMA IMMUNOGLOBULINS
    FREDERICK GARVER; Fiscal Year: 1980
    ..The overall purpose of these studies is to help understand the (1) genetic basis of antibody formation, (2) the nature and origins of the deletions found in heavy chain disease proteins and (3) the localization ..
  28. EPIDERMIS-TARGETED GENE THERAPY FOR HEMOPHILIA A
    Steven Fakharzadeh; Fiscal Year: 2004
    ..Second, the humoral response (anti-factor VIII antibody formation and their inhibitory responses) are monitored in the immunocompetent ko model...
  29. GIF regulation of CD4 T-dependent immune responses
    Katsuji Sugie; Fiscal Year: 2001
    ..GIF inhibits IgG1 and IgE antibody formation when administered around the time of immunization with DNP-Ova...
  30. MECHANISM OF ANTIGEN-INDUCED ANTIBODY FORMATION
    FELIX HAUROWITZ; Fiscal Year: 1980
    Our views on antibody formation underwent recently a revolution initiated by the work of Tonegawa in Basel, (Switzerland) who found that the genes of antibody forming lymphoid cells of animal embryos undergo a drastic rearrangement of ..
  31. IGE AND IGG SUBCLASS FORMATION
    Hans Spiegelberg; Fiscal Year: 1991
    ..that the major cause of allergic diseases is an overproduction of IgE antibodies, the regulation of IgE antibody formation is still poorly understood...
  32. INHIBITOR FORMATION IN GENE THERAPY FOR HEMOPHILIA
    Katherine High; Fiscal Year: 2001
    ..In dogs with hemophilia B resulting from a missense mutation in the F.IX gene, antibody formation following AAV-mediated muscle-directed gene transfer has been either absent or transient and low-level...
  33. Role of CD45 in Hematopoiesis and Lymphomagenesis
    Michelle Hermiston; Fiscal Year: 2005
    ..A subset also develops stigmata of autoimmunity including anti-double stranded DNA antibody formation and immune complex-mediated glomerulonephritis...
  34. GENETICALLY DETERMINED DEFICIENCY OF C3
    Jerry Winkelstein; Fiscal Year: 1991
    ..3) We will determine if C3-deficient dogs have normal antibody formation in order to clarify the role of C3 in antibody formation in vivo...
  35. Lactoferrin as an Adjuvant for Cellular Immunity
    Jeffrey Actor; Fiscal Year: 2002
    ..The only adjuvant licensed for human use, alum, effectively enhances antibody formation, but is seldom effective for inducing CMI...
  36. Immune Mechanisms of Red Cell Alloimmunization
    SALLY CAMPBELL LEE; Fiscal Year: 2005
    ..In order to develop prevention or treatment for this problem, immune mechanisms regulating antibody formation must be better identified...
  37. REAGINIC ANTIBODY FORMATION TO BACTERIAL ANTIGENS
    Gabriel Michael; Fiscal Year: 1980
    In this project we are investigating reaginic (homocytotropic) antibody formation to antigens of gram-negative bacteria and we are attempting to determine whether these antibodies have any role in the development of microbial infections...
  38. ANTIBODY ACTION MECHANISM AGAINST CRYPTOCOCCUS NEOFORMAN
    Marta Feldmesser; Fiscal Year: 2000
    ..information is increasingly important given the ongoing development of a conjugate vaccine which elicits antibody formation. Preliminary data indicated that systemic antibody protects against a primary pulmonary C...
  39. TNFSF APC activators for HIV Vaccines
    RICHARD KORNBLUTH; Fiscal Year: 2003
    ..Vaccine responses will be measured using assays for antibody formation, lymphoproliferative responses, cytokine production, and cytotoxity...
  40. MECHANISMS IN HUMAN CANCER IMMUNOLOGY SYMPOSIUM
    J Saunders; Fiscal Year: 1980
    ..Similar symposia on histocompatibility testing, antibody formation and mediators of cellular immunity have in the past successfully met their goals of synthesizing information ..
  41. REGULATION OF B CELL MEMORY
    Jan Cerny; Fiscal Year: 2000
    ..a specialized pathway in the lymphoid germinal centers (GC) which is different from, and independent of the antibody formation and which includes somatic mutation and selections of cells with high affinity for the antigen...
  42. REGULATORY CELLS IN EXPERIMENTAL PERIODONTAL DISEASE
    Martin Taubman; Fiscal Year: 1999
    ..Other indicators will be antibody formation (ELISA procedure), cell proliferation, and phenotypic analyses using flow cytofluorometry...
  43. ACQUIRED IMMUNODEFICIENCY DISEASE IN HAITIAN CHILDREN
    Gwendolyn Scott; Fiscal Year: 1990
    ..Virus isolates will be characterized and antibody responses to HTLV-III will be measured to evaluate the respective roles of viral variation, antibody formation and clinical disease.
  44. Cytokine-Augmented DNA Vaccine-Elicited Immunity to HIV
    DAN BAROUCH; Fiscal Year: 2005
    ..Raphael Dolin, Dean for Clinical Programs, Harvard Medical School, will guide Dr. Barouch's development as an independent investigator. In addition, a committee of distinguished scientists will oversee his progress toward independence. ..
  45. Familial IgA Nephropathy: Genetic and Metabolic Studies
    Jiri Mestecky; Fiscal Year: 2006
    ..abstract_text> ..
  46. PERIODONTAL DISEASE:ROLE OF ABERRANT Ig GLYCOSYLATION
    Jiri Mestecky; Fiscal Year: 2006
    ..Results of these studies will generate information concerning previously unexplored inflammatory pathways that participate in the development of PD. ..
  47. Augmentation of DNA Vaccine-Elicited Immunity to HIV/SIV
    DAN BAROUCH; Fiscal Year: 2008
    ..The long-term objectives of these studies are to develop novel vaccine regimens that recruit APCs to the site of inoculation in animal models and to consider advancing the most promising strategies into clinical trials. ..
  48. Chemokine Potential in Cancer Immunotherapy
    Dean Johnston; Fiscal Year: 2002
    ..Chemokines that prove effective in these models could be directly translated to clinical trials under the direction of Dr. Jean-Claude Bystryn, the CoPI, at NYU Medical Center. ..
  49. Chimeric Adenovirus Vaccine Vectors for HIV/SIV
    DAN BAROUCH; Fiscal Year: 2005
    ..Within the two-year time frame of this award, sufficient data will be generated with candidate chimeric rAd vaccines to justify further vaccine/challenge studies in rhesus monkeys. ..
  50. Novel Adenovirus Vaccine Vectors for HIV/SIV
    Dan H Barouch; Fiscal Year: 2010
    ..abstract_text> ..
  51. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2009
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  52. Regulation of breast cancer growth by activation peptide
    Vaclav Vetvicka; Fiscal Year: 2006
    ..The overall goal is to generate a pharmacological agent for breast cancer based on blockage of the autocrine growth factor activity of pCD. ..
  53. Immune Response for Hemophilia After Replacement Therapy
    CAROL MIAO; Fiscal Year: 2008
    ..This cell population could potentially be utilized in the future for cellular therapy in this disease setting. ..
  54. Hepatitis C Virus, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2007
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. [unreadable] [unreadable]..
  55. Nonviral Gene Medicine for Hemophilia A
    Carol H Miao; Fiscal Year: 2010
    ..abstract_text> ..
  56. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2008
    ..The proposal addresses a significant issue in autoimmunity and will serve well as a training vehicle to obtain the stated goals by the PI. ..
  57. Mining slime mold for susceptibility genes to fungi
    Arturo Casadevall; Fiscal Year: 2005
    ..discoideum system will lead to the identification of genetic pathways that are not immediately obvious from standard fungal-macrophage experiments. ..
  58. Humoral immune response to acute hepatitis C
    Dale Netski; Fiscal Year: 2006
    ..We believe there is a high likelihood this research will be successful, but submit the work initially as an R21 to prove the feasibility of the pseudotype system. ..
  59. BABAA RECEPTORS IN AGING & ALZHEIMER'S DISEASE
    Samuel Gandy; Fiscal Year: 2002
    ....