Summary: Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.

Top Publications

  1. doi Diversity and dialogue in immunity to helminths
    Judith E Allen
    Institute for Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, UK
    Nat Rev Immunol 11:375-88. 2011
  2. ncbi A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
  3. doi STATs in cancer inflammation and immunity: a leading role for STAT3
    Hua Yu
    Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Nat Rev Cancer 9:798-809. 2009
  4. pmc The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
    Rimantas Sapranauskas
    Institute of Biotechnology, Vilnius University, Graiciuno 8, LT 02241 Vilnius, Lithuania
    Nucleic Acids Res 39:9275-82. 2011
  5. ncbi Neutrophils and immunity: challenges and opportunities
    Carl Nathan
    Department of Microbiology and Immunology, Weill Cornell Medical College, Weill Graduate School of Medical Sciences of Cornell University, Box 57, 1300 York Avenue, New York 10021, USA
    Nat Rev Immunol 6:173-82. 2006
  6. pmc Compartmentalized control of skin immunity by resident commensals
    Shruti Naik
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 337:1115-9. 2012
  7. pmc West Nile virus: immunity and pathogenesis
    Stephanie M Lim
    Department of Virology, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Viruses 3:811-28. 2011
  8. pmc MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity
    Jacqueline G Perrigoue
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Immunol 10:697-705. 2009
  9. doi How do plants achieve immunity? Defence without specialized immune cells
    Steven H Spoel
    Institute of Molecular Plant Sciences, University of Edinburgh, Edinburgh, EH9 3JR, UK
    Nat Rev Immunol 12:89-100. 2012
  10. doi The IRF family transcription factors in immunity and oncogenesis
    Tomohiko Tamura
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Annu Rev Immunol 26:535-84. 2008

Detail Information

Publications361 found, 100 shown here

  1. doi Diversity and dialogue in immunity to helminths
    Judith E Allen
    Institute for Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, UK
    Nat Rev Immunol 11:375-88. 2011
    ..The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to ..
  2. ncbi A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
    ..It has been proposed that their expression is controlled by the non-clonal, or innate, component of immunity that preceded in evolution the development of an adaptive immune system in vertebrates...
  3. doi STATs in cancer inflammation and immunity: a leading role for STAT3
    Hua Yu
    Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Nat Rev Cancer 9:798-809. 2009
    Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment ..
  4. pmc The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
    Rimantas Sapranauskas
    Institute of Biotechnology, Vilnius University, Graiciuno 8, LT 02241 Vilnius, Lithuania
    Nucleic Acids Res 39:9275-82. 2011
    ..In Streptococcus thermophilus, it was previously shown that the CRISPR1/Cas system can provide adaptive immunity against phages and plasmids by integrating novel spacers following exposure to these foreign genetic elements ..
  5. ncbi Neutrophils and immunity: challenges and opportunities
    Carl Nathan
    Department of Microbiology and Immunology, Weill Cornell Medical College, Weill Graduate School of Medical Sciences of Cornell University, Box 57, 1300 York Avenue, New York 10021, USA
    Nat Rev Immunol 6:173-82. 2006
  6. pmc Compartmentalized control of skin immunity by resident commensals
    Shruti Naik
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 337:1115-9. 2012
    ..However, the contribution of tissue-resident commensals to immunity and inflammation at other barrier sites has not been addressed...
  7. pmc West Nile virus: immunity and pathogenesis
    Stephanie M Lim
    Department of Virology, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Viruses 3:811-28. 2011
  8. pmc MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity
    Jacqueline G Perrigoue
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Immunol 10:697-705. 2009
    ..that dendritic cell-mediated priming was insufficient for the development of T helper type 2 cell-dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II ..
  9. doi How do plants achieve immunity? Defence without specialized immune cells
    Steven H Spoel
    Institute of Molecular Plant Sciences, University of Edinburgh, Edinburgh, EH9 3JR, UK
    Nat Rev Immunol 12:89-100. 2012
    ..So how do plants achieve specific, self-tolerant immunity and establish immune memory? Recent developments point towards a multilayered plant innate immune system ..
  10. doi The IRF family transcription factors in immunity and oncogenesis
    Tomohiko Tamura
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Annu Rev Immunol 26:535-84. 2008
    ..Moreover, the role of several IRF family members in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers...
  11. pmc The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems
    Krzysztof Chylinski
    The Laboratory for Molecular Infection Medicine Sweden MIMS, Umeå Centre for Microbial Research UCMR, Department of Molecular Biology, Umea University, Umea, Sweden
    RNA Biol 10:726-37. 2013
    ..The large panel of tracrRNA and Cas9 ortholog sequences should constitute a useful database to improve the design of RNA-programmable Cas9 as genome editing tool. ..
  12. pmc PAMPs and DAMPs: signal 0s that spur autophagy and immunity
    Daolin Tang
    Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Immunol Rev 249:158-75. 2012
    ..In contrast, damage-associated molecular pattern molecules (DAMPs) are cell-derived and initiate and perpetuate immunity in response to trauma, ischemia, and tissue damage, either in the absence or presence of pathogenic infection...
  13. pmc Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity
    Tao Ren
    Genetics Department, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 2:e18. 2006
    ..We identified mutants of L. pneumophila that evade macrophage innate immunity. All mutants were deficient in expression of flagellin, the primary flagellar subunit, and failed to induce ..
  14. pmc Nutritional immunity beyond iron: a role for manganese and zinc
    Thomas E Kehl-Fie
    Vanderbilt University Medical Center, Department of Microbiology and Immunology, USA
    Curr Opin Chem Biol 14:218-24. 2010
    ..Limiting the availability of zinc and manganese as a mechanism to defend against infection expands the spectrum of nutritional immunity and further establishes metal sequestration as a key defense against microbial invaders.
  15. pmc CD39 and CD73 in immunity and inflammation
    Luca Antonioli
    Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
    Trends Mol Med 19:355-67. 2013
  16. doi Oncology meets immunology: the cancer-immunity cycle
    Daniel S Chen
    Stanford Medical Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 39:1-10. 2013
    ..However, elimination of cancer by T cells is only one step in the Cancer-Immunity Cycle, which manages the delicate balance between the recognition of nonself and the prevention of autoimmunity...
  17. doi Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
    Francois Ghiringhelli
    Institut National de la Sante et de la Recherche Medicale, U805, Villejuif, France
    Nat Med 15:1170-8. 2009
    ..These results indicate that the NLRP3 inflammasome links the innate and adaptive immune responses against dying tumor cells...
  18. pmc The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities
    Zhi Huang
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Antioxid Redox Signal 16:705-43. 2012
    ..selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive ..
  19. pmc Activation of the indole-3-acetic acid-amido synthetase GH3-8 suppresses expansin expression and promotes salicylate- and jasmonate-independent basal immunity in rice
    Xinhua Ding
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Plant Cell 20:228-40. 2008
    ..Both enhanced resistance and abnormal development may be caused by inhibition of the expression of expansins via suppressed auxin signaling...
  20. doi MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation
    Eniko Sonkoly
    Molecular Dermatology Research Group, Unit of Dermatology and Venerology, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, SE 17176 Stockholm, Sweden
    Semin Cancer Biol 18:131-40. 2008
    ..Although we are still at a very early stage in understanding their impact on immunity, miRNAs are changing the way we think about the development of the immune system and regulation of immune ..
  21. pmc Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity
    Yiqi Guo
    1St Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA Laboratory of Human Genetics of Infectious Diseases, National Institute of Health and Medical Research, Paris, France Necker Medical School, Paris Descartes University, Paris 75015, France
    J Exp Med 208:2083-98. 2011
    ..These findings identify a new genetic etiology for childhood HSE, indicating that TLR3-mediated immunity is essential for protective immunity to HSV-1 in the central nervous system (CNS) during primary infection in ..
  22. ncbi Toll-like receptors: critical proteins linking innate and acquired immunity
    S Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 2:675-80. 2001
    ..However, evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses...
  23. doi Ubiquitylation in innate and adaptive immunity
    Vijay G Bhoj
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 458:430-7. 2009
    ..Recent work has shown that several ubiquitin ligases help to prevent the immune system from attacking self tissues. The dysfunction of several ubiquitin ligases has been linked to autoimmune diseases...
  24. pmc Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
    A Diefenbach
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley 94720, USA
    Nature 413:165-71. 2001
    Natural killer (NK) cells attack many tumour cell lines, and are thought to have a critical role in anti-tumour immunity; however, the interaction between NK cells and tumour targets is poorly understood...
  25. pmc Interleukin-2 receptor signaling: at the interface between tolerance and immunity
    Thomas R Malek
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, PO Box 01960, Miami, FL 33101, USA
    Immunity 33:153-65. 2010
    Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the contribution of IL-2 for T cell-dependent activity in ..
  26. pmc Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
    Donna L Mallery
    Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 107:19985-90. 2010
    Antibodies provide effective antiviral immunity despite the fact that viruses escape into cells when they infect...
  27. ncbi Interferons, immunity and cancer immunoediting
    Gavin P Dunn
    Washington University School of Medicine, Department of Pathology and Immunology, Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Rev Immunol 6:836-48. 2006
    ..More recently, type I IFNs have been found to have distinct functions in this process. In this Review, we discuss the roles of the IFNs, not only in cancer immunosurveillance but also in the broader process of cancer immunoediting...
  28. pmc The outs and the ins of sphingosine-1-phosphate in immunity
    Sarah Spiegel
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Nat Rev Immunol 11:403-15. 2011 two closely related kinases, sphingosine kinase 1 (SPHK1) and SPHK2, and has emerged as a crucial regulator of immunity. Many of the actions of S1P in innate and adaptive immunity are mediated by its binding to five G protein-coupled ..
  29. pmc Influenza virus-like particles containing M2 induce broadly cross protective immunity
    Jae Min Song
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 6:e14538. 2011
    ..An influenza vaccine that can confer cross-protection against antigenically different influenza A strains is highly desirable for improving public health...
  30. pmc Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution
    Peter Parham
    Department of Structural Biology, Stanford University, Stanford, California 94305, USA
    Nat Rev Immunol 13:133-44. 2013
    Natural killer (NK) cells have roles in immunity and reproduction that are controlled by variable receptors that recognize MHC class I molecules...
  31. pmc Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display
    Tim J Schuijt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e15926. 2011
    Repeated exposure of rabbits and other animals to ticks results in acquired resistance or immunity to subsequent tick bites and is partially elicited by antibodies directed against tick antigens...
  32. doi Immunity to salmonellosis
    Gordon Dougan
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Immunol Rev 240:196-210. 2011
    ..Both humoral and cellular responses can be detected and characterized, but full protective immunity is not always induced, even following natural infection...
  33. pmc Signaling of interleukin-17 family cytokines in immunity and inflammation
    Seon Hee Chang
    Department of Immunology and Center for Inflammation and Cancer, M D Anderson Cancer Center, Houston, TX, USA
    Cell Signal 23:1069-75. 2011
    IL-17 cytokine family, though still young since discovery, has recently emerged as critical players in immunity and inflammatory diseases. The prototype cytokine, IL-17A, plays essential roles in promoting inflammation and host defense...
  34. doi Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma
    Wendy Anne Boivin
    UBC James Hogg Research Laboratory, Providence Heart and Lung Institute at St Paul s Hospital, Vancouver, BC V6Z 1Y6, Canada
    Lab Invest 89:1195-220. 2009
    ..This review examines, for the first time, the multiple roles of GrB in disease pathogenesis...
  35. ncbi Evolutionary ecology of insect immune defenses
    Paul Schmid-Hempel
    Ecology and Evolution, ETH Zurich, ETH Zentrum NW, CH 8092 Zurich, Switzerland
    Annu Rev Entomol 50:529-51. 2005
    ..In addition, the field is now rapidly becoming revolutionized by molecular data and methods that allow unprecedented access to study evolution in action...
  36. pmc TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis
    Betsy C Taylor
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 206:655-67. 2009
    ..thymic stromal lymphopoietin (TSLP); however, the in vivo influence of TSLP-TSLP receptor (TSLPR) interactions on immunity and inflammation in the intestine remains unclear...
  37. ncbi Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter
    M Mohrs
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California, San Francisco 94143, USA
    Immunity 15:303-11. 2001
    Effector T cells mediate adaptive immunity and immunopathology, but methods for tracking such cells in vivo are limited...
  38. ncbi Chemokines and their receptors: drug targets in immunity and inflammation
    Antonella Viola
    Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
    Annu Rev Pharmacol Toxicol 48:171-97. 2008
    The chemokine system coordinates leukocyte migration in immunity and inflammation and is implicated in the pathogenesis of many human diseases...
  39. pmc Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
    Emma Slack
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada
    Science 325:617-20. 2009
    ..Spontaneous hyper-activation of adaptive immunity against the intestinal microbiota, secondary to innate immune deficiency, may clarify the underlying mechanisms ..
  40. pmc Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria
    Roberta Spaccapelo
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Am J Pathol 176:205-17. 2010
    ..Real-time in vivo parasite imaging and splenectomy experiments demonstrated that protective immunity acted through antibody-mediated parasite clearance in the spleen...
  41. pmc Immune pathways and defence mechanisms in honey bees Apis mellifera
    J D Evans
    USDA ARS Bee Research Laboratory, Beltsville, MD, USA
    Insect Mol Biol 15:645-56. 2006
    ..Here we focus on individual defences, by presenting a genome-wide analysis of immunity in a social insect, the honey bee Apis mellifera...
  42. doi The proPO-system: pros and cons for its role in invertebrate immunity
    Lage Cerenius
    Department of Comparative Physiology, Uppsala University, 752 36 Uppsala, Sweden
    Trends Immunol 29:263-71. 2008
    ..RNA interference against phenoloxidase or in specific host-pathogen interactions where the pathogen prevents melanin production by the host, convincing data have confirmed the importance of this cascade in invertebrate innate immunity.
  43. ncbi Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
    Curr Opin Immunol 12:64-76. 2000
    ..There is recent evidence for additional functions of these oxygen metabolites in innate and adaptive immunity; these functions include the modulation of the cytokine response of lymphocytes and the regulation of immune cell ..
  44. doi Paleovirology and virally derived immunity
    Amr Aswad
    Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK
    Trends Ecol Evol 27:627-36. 2012
    ..In this review, we consider the genes and processes involved in EVE-derived immunity (EDI), assess factors leading to its emergence, and outline how future work will benefit from incorporating ..
  45. pmc The population and evolutionary dynamics of phage and bacteria with CRISPR-mediated immunity
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Genet 9:e1003312. 2013
    ..of a BIM-CEM arms race than predicted from existing assumptions about phage infection and CRISPR-cas immunity. Among the unanticipated observations are: (i) the invasion of phage into populations of BIMs resistant by the ..
  46. pmc Susceptibility and immunity to helminth parasites
    Rick M Maizels
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    Curr Opin Immunol 24:459-66. 2012
    ..has been made in the last two years in determining the cells and cytokines involved in induction of Type 2 immunity, which is generally protective against helminth infection...
  47. doi Decoding cell death signals in inflammation and immunity
    Laurence Zitvogel
    INSERM, Villejuif, France
    Cell 140:798-804. 2010
    ..We speculate that combinations of these molecules determine the route by which dying cells are engulfed and the nature of the immune response that their death elicits...
  48. pmc Assessing the role of CD103 in immunity to an intestinal helminth parasite
    Sarah C Mullaly
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 6:e19580. 2011
    ..However, the role of CD103 during intestinal helminth infection has not been tested...
  49. pmc The neurology of the immune system: neural reflexes regulate immunity
    Mauricio Rosas-Ballina
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Neuron 64:28-32. 2009
    ..Like other physiological systems, the immune system--and the development of immunity--is modulated by neural reflexes...
  50. pmc IRF4: Immunity. Malignancy! Therapy?
    Arthur L Shaffer
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Clin Cancer Res 15:2954-61. 2009
    ..Interference with IRF4 expression is lethal to multiple myeloma cells, irrespective of their genetic etiology, making IRF4 an "Achilles' heel" that may be exploited therapeutically...
  51. doi Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:2076-82. 2009
    ..Here, we review our current understanding of CD4(+) T-cell lineage heterogeneity and flexibility, with emphasis on the human system, and propose an organization of effector and memory T cells based on distinct functional modules...
  52. pmc Interleukin-17A mediates acquired immunity to pneumococcal colonization
    Ying Jie Lu
    Department of Medicine, Division of Infectious Diseases, Children s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 4:e1000159. 2008
    Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability to clear colonization before these antibodies appear, suggesting involvement of other mechanisms...
  53. doi PD-1 and its ligands in tolerance and immunity
    Mary E Keir
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115 5727, USA
    Annu Rev Immunol 26:677-704. 2008
    ..The PD-1:PD-L pathway also has been usurped by microorganisms and tumors to attenuate antimicrobial or tumor immunity and facilitate chronic infection and tumor survival...
  54. ncbi Impaired immune and acute-phase responses in interleukin-6-deficient mice
    M Kopf
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Nature 368:339-42. 1994
    ..We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes...
  55. pmc The obligate mutualist Wigglesworthia glossinidia influences reproduction, digestion, and immunity processes of its host, the tsetse fly
    Roshan Pais
    Yale School of Public Heath, Department of Epidemiology of Microbial Diseases, New Haven, CT 06520, USA
    Appl Environ Microbiol 74:5965-74. 2008
    ..The ability to rear adult tsetse that lack the obligate Wigglesworthia endosymbionts will now enable functional investigations into this ancient symbiosis...
  56. doi Integrins in immunity
    Rachel Evans
    Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:215-25. 2009
    ..In this Commentary, we highlight, from a cell-biology point of view, the integrin-mediated immune-cell migration and cell-cell interactions that occur during the course of an immune response...
  57. pmc Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency
    Dusan Bogunovic
    St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
    Science 337:1684-8. 2012
    ..Its conjugation to various proteins (ISGylation) contributes to antiviral immunity in mice...
  58. pmc Follicular helper T cells in immunity and systemic autoimmunity
    Joseph E Craft
    Department of Internal Medicine, Yale University School of Medicine, PO Box 208031, 300 Cedar Street, New Haven, CT 06520 8031, USA
    Nat Rev Rheumatol 8:337-47. 2012
    ..Such information might improve our understanding of autoimmune diseases, such as SLE, and highlights the potential of T(FH) cells as therapeutic targets in these diseases...
  59. pmc CCR6 as a mediator of immunity in the lung and gut
    Toshihiro Ito
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Exp Cell Res 317:613-9. 2011
    ..CCR6 is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and ..
  60. doi Regulation of immunity and oncogenesis by the IRF transcription factor family
    David Savitsky
    Department of Immunology, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Immunol Immunother 59:489-510. 2010
    ..In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis...
  61. ncbi Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
    C S Lantz
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 392:90-3. 1998
    ..and function of tissue mast cells and blood basophils, which are thought to be important effector cells in immunity to parasites and other immunological responses, such as allergic reactions...
  62. pmc CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior
    Roy L Silverstein
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Sci Signal 2:re3. 2009
    ..Identification of the precise CD36 signaling pathways in specific cells elicited in response to specific ligands may yield novel targets for drug development...
  63. pmc RNA-based viral immunity initiated by the Dicer family of host immune receptors
    Roghiyh Aliyari
    Department of Plant Pathology and Microbiology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Immunol Rev 227:176-88. 2009
    ..This viral immunity begins with recognition of viral double-stranded or structured RNA by the Dicer nuclease family of host immune ..
  64. pmc Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model
    Regis Gomes
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, CEP 40296 710 Salvador, Brazil
    Proc Natl Acad Sci U S A 105:7845-50. 2008 the viscera of LJM19-immunized hamsters through direct parasite killing and/or priming of anti-Leishmania immunity. We have shown that immunity to a defined salivary protein (LJM19) confers powerful protection against the fatal ..
  65. doi The multiple faces of CXCL12 (SDF-1alpha) in the regulation of immunity during health and disease
    Nathan Karin
    Department of Immunology, Bruce Rappaport Faculty of Medicine and Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, 1 Efron St, Haifa 31096, Israel
    J Leukoc Biol 88:463-73. 2010
    ..The current review explores the different biological properties of CXCL12 and discusses the implications of CXCL12-based therapies for autoimmunity and cancer diseases...
  66. doi Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity
    Alejandro Gallardo-Soler
    Departamento de Bioquimica y Biologia Molecular y Genetica, Universidad de Extremadura Avenida de la Universidad s n, 10071 Caceres, Spain
    Mol Endocrinol 22:1394-402. 2008
    Macrophages are phagocytic cells that play essential roles in innate immunity and lipid homeostasis. The uptake of modified lipoproteins is an important early event in the development of atherosclerosis...
  67. pmc Review of the activation of TGF-beta in immunity
    Andrew W Taylor
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    J Leukoc Biol 85:29-33. 2009
    ..In immunity, TGF-beta has an important role in modulating immunity...
  68. doi Sirtuin deacylases: a molecular link between metabolism and immunity
    Nicolas Preyat
    Laboratory of Immunobiology, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, Gosselies, Belgium
    J Leukoc Biol 93:669-80. 2013
    ..These observations will be summarized herein and the possible strategies that may lead to the development of novel therapeutic approaches to treat inflammation briefly discussed...
  69. doi Strong bias in the bacterial CRISPR elements that confer immunity to phage
    David Páez-Espino
    Department of Earth and Planetary Science, University of California, Berkeley, Berkeley, California, USA
    Nat Commun 4:1430. 2013
    Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems provide adaptive immunity against phage via spacer-encoded CRISPR RNAs that are complementary to invasive nucleic acids...
  70. pmc Signaling by myeloid C-type lectin receptors in immunity and homeostasis
    David Sancho
    Department of Vascular Biology and Inflammation, CNIC, Centro Nacional de Investigaciones Cardiovasculares, E 28029, Madrid, Spain
    Annu Rev Immunol 30:491-529. 2012
    ..Here, we review the signaling properties of myeloid CLRs and how they impact the role of myeloid cells in innate and adaptive immunity.
  71. ncbi Tip of another iceberg: Drosophila serpins
    Jean Marc Reichhart
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 rue Rene Descartes, F67084 Strasbourg Cedex, France
    Trends Cell Biol 15:659-65. 2005
    ..Spn43Ac controls the Toll pathway during the immune response. In each case, Drosophila genetics has shed new light on the function of these serine protease inhibitors...
  72. doi Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms
    Pradipta R Rauta
    Department of Life Science, National Institute of Technology, Rourkela 769008, Odisha, India
    Immunol Lett 148:23-33. 2012
    ..basal position of fish in vertebrate phylogeny makes them very attractive for genomic and functional comparative immunity studies...
  73. pmc Immunity in a variable world
    Brian P Lazzaro
    Department of Entomology, Cornell University, Ithaca, NY 14850, USA
    Philos Trans R Soc Lond B Biol Sci 364:15-26. 2009
    ..Here, we review some of the literature emphasizing the complexity of natural selection on immunity. Our aim is to describe how environmental and genetic heterogeneities, often excluded from experimentation as '..
  74. pmc Sublingual immunization with M2-based vaccine induces broad protective immunity against influenza
    Byoung Shik Shim
    Laboratory Science Division, International Vaccine Institute, Seoul, Republic of Korea
    PLoS ONE 6:e27953. 2011
    ..The mechanism whereby s.l. immunization with M2e vaccine candidate induces broad protection against infection with different influenza virus subtypes was explored...
  75. doi Immunity to the respiratory pathogen Bordetella pertussis
    R Higgs
    Immunology Research Centre, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Dublin, Ireland
    Mucosal Immunol 5:485-500. 2012
    ..and antimicrobial peptides help to control the infection, while complete bacterial clearance requires cellular immunity mediated by T-helper type 1 (Th1) and Th17 cells...
  76. ncbi Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?
    Uwe Schonbeck
    Leducq Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 109:II18-26. 2004
    ..This overview addresses the controversy by reviewing in vitro and in vivo evidence regarding statins as antiinflammatory agents...
  77. pmc Evolutionary history of the cancer immunity antigen MAGE gene family
    Yukako Katsura
    Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies Sokendai, Hayama, Kanagawa, Japan
    PLoS ONE 6:e20365. 2011
    ..These findings are interpreted with consideration of the biological factors shaping recent human MAGE-A genes...
  78. pmc Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB)
    Anastasiya Yermakova
    Department of Biomedical Sciences, University at Albany School of Public Health, Albany, NY 12201, USA
    Vaccine 29:7925-35. 2011
    ..These data raise the possibility of using specific RTB sub-domains, rather than RTB itself, as antigens to more efficiently elicit neutralizing antibodies and protective immunity against ricin.
  79. doi Estrogen receptors in immunity and autoimmunity
    Melissa Cunningham
    Medical Research Service, Ralph H Johnson VAMC and the Department of Medicine, Division of Rheumatology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425, USA
    Clin Rev Allergy Immunol 40:66-73. 2011
    ..The protective effect of ERα in lupus is multifactoral. In arthritis models, ERα agonists appears to mediate a protective effect. The modulation of ERα function appears to be a potential target for therapy in autoimmunity...
  80. doi Mast cells as regulators of skin inflammation and immunity
    Ilkka T Harvima
    Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, P O Box 1777, FIN 70210 Kuopio, Finland
    Acta Derm Venereol 91:644-50. 2011
    ..allergy, but experimental evidence obtained during the last decade has revealed their role in innate and acquired immunity. Upon activation mast cells can undergo an anaphylactic or piecemeal degranulation or degranulation-independent ..
  81. doi Probiotics and immunity
    Andrea T Borchers
    Department of Nutrition, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA
    J Gastroenterol 44:26-46. 2009
    ..However, the findings are too variable to allow firm conclusions as to the effectiveness of specific probiotics in these conditions...
  82. doi The Ikaros gene family: transcriptional regulators of hematopoiesis and immunity
    Liza B John
    School of Medicine, Deakin University, Waurn Ponds, Victoria 3217, Australia
    Mol Immunol 48:1272-8. 2011
    ..This review describes the key roles of Ikaros proteins in development and disease, their mechanisms of action and gene targets, as well as explaining their evolutionary origins and role in the emergence of adaptive immunity.
  83. ncbi Effects of cigarette smoke on the lung and systemic immunity
    J Domagala-Kulawik
    Department of Internal Medicine, Pneumology and Allergology, Warsaw Medical University, Warsaw, Poland
    J Physiol Pharmacol 59:19-34. 2008
    ..Smoking cessation is the most effective method of prophylaxis and treatment of diseases related to tobacco smoking. However many immunological changes in smokers are not completely reversible after quitting smoking...
  84. pmc Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites
    Nathan W Schmidt
    Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Pathog 6:e1000998. 2010
    ..activation marker approach allowed us for the first time to evaluate CD8 T cell responses and protective immunity following RAS-immunization in outbred hosts...
  85. pmc Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype
    Norman Yeh
    Department of Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 185:2089-98. 2010
    ..IL-17-secreting CD8 T cells, termed Tc17 cells, were shown to promote inflammation and mediate immunity to influenza. However, most reports observed a lack of cytotoxic activity by Tc17 cells...
  86. doi Sero-immunity and serologic response to pandemic influenza A (H1N1) 2009 virus in Hong Kong
    Gannon C Mak
    Virology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Kowloon, Hong Kong
    J Med Virol 82:1809-15. 2010
    To study the serologic response to the new pandemic influenza A (H1N1) 2009 virus in Hong Kong, the level of immunity was measured before and after the occurrence of the outbreak, and the titer of antibody to the pandemic influenza A (..
  87. pmc Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells
    Habib Zaghouani
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Trends Immunol 30:585-91. 2009
    b>Immunity in the newborn is characterized by minimal T helper (Th)1 function but an excess of Th2 activity...
  88. doi Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule
    Toshio Hirano
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Adv Immunol 97:149-76. 2008
    ..We also review recent progress in uncovering the roles of Zn in the immune system...
  89. doi Primary immunodeficiencies of protective immunity to primary infections
    Aziz Bousfiha
    Clinical Immunology Unit, Department of Pediatrics, CHU Ibn Rochd, Casablanca, Morocco
    Clin Immunol 135:204-9. 2010
    ..predispose affected individuals to recurrent or chronic infectious diseases, because they affect protective immunity to both primary and secondary or latent infections...
  90. pmc A model 450 million years in the making: zebrafish and vertebrate immunity
    Stephen A Renshaw
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
    Dis Model Mech 5:38-47. 2012 an entire vertebrate organism, complemented by increasing recognition that zebrafish and vertebrate immunity have many aspects in common...
  91. pmc Inborn errors of immunity to infection: the rule rather than the exception
    Jean Laurent Casanova
    Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, Pediatric Hematology Immunology Unit, Necker Enfants Malades Hospital, Paris, France
    J Exp Med 202:197-201. 2005
    ..We argue here that most individuals retain a natural vulnerability to infectious diseases, reflecting a great diversity of inborn errors of immunity.
  92. pmc Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans
    Violeta Chavez
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Genetics 176:1567-77. 2007
    ..Because insulin-signaling mutants overproduce oxidative stress response enzymes, the model provides an explanation for their increased resistance to pathogens...
  93. pmc OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
    Silvia Piconese
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
    J Exp Med 205:825-39. 2008
    ..In addition, the known OX40-dependent delivery of fitness signals to activated T cells is boosted by concurrent T reg cell inhibition. OX40 triggering thus has multiple effects that converge to mediate tumor rejection...
  94. ncbi Synergism of nutrition, infection, and immunity: an overview
    N S Scrimshaw
    Food and Nutrition Programme for Human and Social Development, United Nations University Program Office, Boston, MA 02114 0500, USA
    Am J Clin Nutr 66:464S-477S. 1997
    ..The effects observed with single or multiple nutrient deficiencies are due to some combination of these responses. In general, cell-mediated and nonspecific immunity are more sensitive than humoral immunity.
  95. ncbi Fc-receptors as regulators of immunity
    Falk Nimmerjahn
    Laboratory for Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Erlangen 91054, Germany
    Adv Immunol 96:179-204. 2007
    ..Moreover, we will focus on exogenous factors that can influence the balanced triggering of activating and inhibitory FcRs, such as the cytokine milieu and the role of differential antibody glycosylation...
  96. ncbi Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo
    Robert C Alaniz
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 179:7692-701. 2007
    ..inflammatory properties as well as B and T cell Ags known to influence the development of Salmonella-specific immunity to infection in vivo...
  97. doi Fungal LysM effectors: extinguishers of host immunity?
    Ronnie de Jonge
    Laboratory of Phytopathology, Wageningen University, 6709 PD Wageningen, The Netherlands
    Trends Microbiol 17:151-7. 2009
    ..that these putative LysM effectors might have a role in sequestration of chitin oligosaccharides - breakdown products of fungal cell walls that are released during invasion and act as triggers of host immunity - to dampen host defence.
  98. ncbi Mini-review: defense strategies and immunity-related genes
    John Trowsdale
    Department of Pathology, and Cambridge Institute for Medical Research, University of Cambridge, Cambridge, GB
    Eur J Immunol 34:7-17. 2004
    ..Key examples are MHC and KIR genes, where features such as polygeny and polymorphism facilitate the comprehensive logistics needed to counteract infection...
  99. doi The NF-kappaB-independent functions of IKK subunits in immunity and cancer
    Alain Chariot
    Interdisciplinary Cluster for Applied Genoproteomics GIGA R, GIGA Signal Transduction, Laboratory of Medical Chemistry, CHU, Sart Tilman, University of Liege, Belgium
    Trends Cell Biol 19:404-13. 2009
    ..Here, I describe how IKK subunits can have crucial roles in allergy, inflammation and immunity by targeting proteins such as SNAP23 and IRF7, but also in cancer by phosphorylating key molecules such as p53, ..
  100. pmc Protective immunity to Schistosoma haematobium infection is primarily an anti-fecundity response stimulated by the death of adult worms
    Kate M Mitchell
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 109:13347-52. 2012
    Protective immunity against human schistosome infection develops slowly, for reasons that are not yet fully understood...
  101. pmc mTOR, linking metabolism and immunity
    Xiaojin Xu
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Immunol 24:429-35. 2012
    ..recent advances in the field, with a focus on the mechanisms through which mTOR regulates cellular and humoral immunity. Further understanding will enable the manipulation of mTOR signaling to direct the biological functions of ..

Research Grants74

    Linda Saif; Fiscal Year: 2006
    ..outer capsid VP4, VP7, and NSP4 sero/genotypes) have hindered identification of the determinants of protective immunity. Both the complexity of RV and the need to induce intestinal immunity in infants have impeded development of ..
  2. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  3. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  4. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Pathogens are transmitted by blood transfusion, and altered host immunity from hypersplenism and iron overload contribute to the morbidity...
  5. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..This proposal seeks to develop biomaterials that promote a life-long immunity protection against infections of long-term indwelling biomedical devices...
  6. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..substrate for CPB and providing a novel molecular link between hemostasis/thrombosis and tissue inflammation and immunity. Aim 1. To determine the biology of OPN-R and OPN-L in human glioblastoma (GBM)...
  7. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..1: To compare the role of antigen specific IgA, IgG and IgM immune responses in macaques with different levels of immunity to SIV/SHIV infection...
  8. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..could be applied towards a broader understanding of the dynamics of other immune cells during infection and immunity. Ultimately, our research will facilitate better comprehension of immunological disorders that result from ..
  9. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..A wide variety of approaches are now being tried to stimulate tumor immunity by 12 T cells using tumor-specific peptide antigens...
  10. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..Because virtually all of the limited information available concerning the determinants of protective mucosal immunity comes from studies in adults, we will also focus some efforts in exploring the responses to oral immunization ..
  11. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..MSC are being utilized experimentally and clinically to mediate inflammation and immunity in a variety of settings;however, the impact of MSC MHC in relation to the recipient and to the cellular or solid ..
    Chella David; Fiscal Year: 2009
    ..of association of DR/DQ with arthritis by studying its interaction with receptors involved in innate and adaptive immunity via 1) binding to calreticulin, an established innate immunity receptor, and triggering signaling, 2) by ..
  13. Trichothecene Toxicity and the Ribotoxic Stress Response
    James J Pestka; Fiscal Year: 2012
    ..include: 1) improved understanding of the molecular basis by which trichothecenes and other ribotoxins disrupt immunity, 2) enhanced capacity to assess and manage risks associated with exposure to trichothecenes and other ribotoxins, ..
  14. Cellular &Molecular Defects in Human B Cell Development
    Charlotte Cunningham-Rundles; Fiscal Year: 2013
    ..Aside from these pathways, the genetic factors that promote anti-bacterial immunity in humans are largely unknown, thus we have also undertaken a genome-wide approach, investigating patients with ..
  15. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..hypotheses: Specific Aim 1: Assess the relationships between chronic sleep restriction and the SNS in enhancing immunity to the autoantigen CII and worsening of arthritis severity in the CIA model...
  16. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..cellular proliferation and fibrosis during the wound healing response and effector cells of T helper type 2 (TH2) immunity. Schistosoma mansoni is a major human pathogen affecting 108 people worldwide that causes fibrotic granulomatous ..
  17. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..scientific barriers: 1) increasing the versatility and efficacy of current vaccines by enhancing cell-mediated immunity through targeting of the epidermal Langerhans cells (LCs), and 2) enabling existing vaccine antigens to be co-..
  18. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..within diverse locations in the host and respond by appropriately altering their cell surface structures to avoid immunity and promote colonization...
  19. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ..Project 3 will analyze heterologous immunity in flavivirus infections, defining the effects of amino acid variations on cross-reactive T-cell responses in ..
  20. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..It is anticipated the outcome of this project will identify key central components of innate and adaptive immunity within the CNS and peripheral tissues (including sensory ganglia and cornea) that are critical for viral ..
  21. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    ..TLRs recognize components derived from microbial pathogens and play a central role in innate immunity. However, abnormal TLR activation can modulate human immunodeficiency or autoimmunity...
  22. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..Objective 2. To determine the role of complement proteins in the activation of innate and adaptive immunity in human emphysema/COPD...
  23. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ..provide sufficient protection of DNA plasmid during transportation, as wel as low- responses to any existing self-immunity. Deficient viral particles, such as adenoviruses or retroviruses, offer an attractive option with great benefits ..
  24. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..attenuated Salmonella vaccine vector systems for animals and humans that are capable of inducing cross-protective immunity to enteric pathogens and of delivering genus- or species-specific protective antigens to further enhance ..
  25. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..We have developed a cardiotropic chimeric of AAV that specifically targets the heart and escapes the inherent immunity in patients and it is this new cardiotropic vector when combined with a novel well validated target that will ..
  26. Development of Vaccines against Clostridium difficile Infection
    SAUL R TZIPORI; Fiscal Year: 2013 to design a vaccine that targets both TcdA and TcdB, with a view to elicit strong systemic and mucosal immunity to prevent CDI, reduce the severity, or eliminate an ongoing chronic disease...
  27. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..PDC have recently been shown to play a role in induction of Th1 immunity against influenza and HSV-1 and are recruited in mouse infection models to lymph nodes to stimulate antiviral ..
    Rafi Ahmed; Fiscal Year: 2013
    ..YFV-17D and smallpox, (ii) innate immune mechamisms by which YFV-17D acts to launch a broad and robust T cell immunity, (iii) genomic signatures capable of predicting the T cell immunogenicity of YFV-17D in humans and (iv) ..
  29. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..that will provide diagnostic and prognostic insight into chronic lung disease, and its impact on innate immunity and secondary infections commonly associated with these disorders...
  30. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..These specialized antigen-presenting cells (APCs) mediate innate immunity, subsequent activation of the adaptive immune system and in the development of immune tolerance...
  31. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..pylori colonization and gastritis;B) GMac phenotype and function;and C) Adaptive immunity in gastric tissues, splenocytes, and lymphocytes. 2...
  32. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..sequelae that links the generalized innate immune response with more specific immunological systems (adaptive immunity)...
  33. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..elaboration have recently been approved for the treatment of psoriasis;however this drug can also suppress Th1 immunity and theoretically increase the risk of infection with intracellular pathogens...
  34. Mechanisms of Neutralizing Antibody Resistance in Chronic HCV and HIV Infection
    JUSTIN RICHARD BAILEY; Fiscal Year: 2013
    ..Diseases Division at Johns Hopkins Hospital and an internationally- recognized expert in HCV virology, humoral immunity, and computational biology and Dr. James E. Crowe, Jr...
  35. Characterizing TLR Function of Human Dendritic Cells in the Elderly
    Alexander Panda; Fiscal Year: 2012
    ..focus his research on understanding age-associated changes in human immune responses, with an emphasis on innate immunity. His long-term career goal is to obtain a tenure-track position at an academic institution with a majority of his ..
  36. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..Understanding how commensal bacteria shape our immune system, both innate and adaptive immunity, is critical to explain how inflammatory diseases including autoimmune disease, develop and to design new ..
  37. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..In addition, the current alum-based vaccine does not induce the type of cell-mediated immunity necessary to treat patients who cannot clear HBV...
  38. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ..both of these organs harbor resident immune cells for providing host defense in these tissues, this indigenous immunity is not sufficient to protect against succumbing to illness and even mortality from prevalent respiratory and ..
  39. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..We and others have shown that vaccine immunity to this and other fungal infections is mediated by a dominant T1-cell response...
  40. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..These adaptations have been well described in many cases, but generating protective immunity in humans has so far proven an insurmountable challenge...
  41. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    ..proteome-based identification of antigens that have a high probability of inducing protective cellular immunity when formulated and administered as a vaccine...
  42. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ..on defects associated with TRAF6 deficiency that impinge on hematopoiesis and osteoclastogenesis (Aim 1), innate immunity versus pathologic inflammation (Aim 2), and adaptive immunity (Aim 3)...
  43. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..In other studies, we will test the hypothesis that adaptive immunity and in particular T cells and the cytokine IL-17 contribute to arterial stiffening...
  44. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..Understanding the impact of VAD on gut immunity is critical to improve oral vaccine efficacy in VAD infants in developing countries...
  45. Knockdown of Gene Expression in Immune Cells in Humanized Mice
    Judy Lieberman; Fiscal Year: 2010
    ..mice transplanted with human bone marrow, fetal liver and thymus (BLT mice) and use it to manipulate human immunity in vivo...
  46. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..pathogenesis of chlamydial genital infection;and 3) to determine if the neurogenic inflammatory pathway affects immunity to reinfection in the genital tract...
  47. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..readout of passively acquired autoimmunity, provides an exceptional opportunity to examine the effector arm of immunity and define the mechanism whereby an Ab mediates fibrosis, which is particularly aberrant in fetal wounding...
  48. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    ..antgiotensin 1 converting enzyme 2 (ACE2) in the prevention of acute lung injury and by the induction of innate immunity and complement. We will identify the genetic factors in the virus and host that regulate SARS-CoV pathogenesis...
  49. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..Mtb-infected alveolar macrophages (AMF) and slow to deliver bacilli to the thoracic lymph nodes (TLN) where immunity is primed...
  50. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    ..In this manner, DDB1 regulates diverse cellular functions such as DNA replication, cell cycle, innate immunity, and damaged DNA repair...
  51. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..the same animals, we will be able to carry out secondary analyses to uncover additional correlations between immunity and neuro- endocrine function in the aged primate...
  52. Immune Development: Role of Milk Cell Transfer and Recipient Gender
    Ameae M Walker; Fiscal Year: 2013
    ..susceptibility to immune disease and the efficacy of immunization, and c) to the possibility of safely enhancing immunity in young children...
  53. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    ..Furthermore, these specific aims may subsequently lead to improved risk stratification, resource utilization, and the development of novel anti-complement therapies to protect against hyperglycemic cardiovascular complications. ..
  54. Moffitt Skin Cancer SPORE
    Jeffrey S Weber; Fiscal Year: 2013
    ..In this Skin SPORE application, the melanoma projects will focus on research in melanoma biology, immunity and signaling that create opportunities to potentiate current and developing clinical approaches to the treatment ..
  55. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    ..Thus, decreased B lymphopoiesis may be causal in the aging- associated decline in humoral immunity to newly encountered pathogens...
  56. The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    KATHERINE YUDEH KING; Fiscal Year: 2013
    ..avium infection, and that the process is dependent on interferon-3 (IFN3) and its downstream effector Irgm1 (Immunity-related GTPase M). I propose to delineate the role of IFN3 in the HSC response to infection by conducting M...
  57. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
  58. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ..We believe that a possible additional candidate affecting mucosal immunity in health and disease is FPR...
  59. Regulation of IFN-beta induction by P2X7 purinergic receptor signaling
    JUDITH ANNE SMITH; Fiscal Year: 2011
    ..Type I IFNs play important roles in diverse aspects of innate and adaptive immunity. As both IFN- [unreadable] and purinergic receptor signaling have been implicated in bacterial sepsis and bone ..
  60. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..The search for protective immunity against invasive S. aureus disease has been a goal since the discovery of this microbe...
  61. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    ..maturation phase of the immune system, and there is evidence that farm exposures enhance development of innate immunity and T regulatory (Treg) cell function...
  62. Validation of microRNAs as therapeutic targets in hematological malignancies
    Natarajan Muthusamy; Fiscal Year: 2013
    ..gene silencing and miR-181a in tumor suppressor activity by modulating pathways involved in mechanisms of innate immunity, regulating Toll like receptor 4, IL-[unreadable] and miR155 expression in AML cell lines and primary blasts...
  63. Evolution of the Immune Response to Cytomegalovirus Transmitted via Breast Milk
    Lynn Puddington; Fiscal Year: 2010
    ..Define how breast milk-mediated transmission of MCMV impacts the development of antiviral immunity in offspring and AIM 2...
  64. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..airway surface liquid (ASL) that contains many antibacterial peptides which play an important role in innate immunity. The antibacterial activity of ASL is NaCI (salt) sensitive...
  65. Mucosal Immunity and Influenza Vaccines: Phenotype and Role of Activated B Cells
    HARRY BERNARD GREENBERG; Fiscal Year: 2010
    ..Although B cell responses are considered a critical component of the influenza mucosal immunity, traditional analyses of B cell immunity after influenza vaccination have been largely limited to studies of ..
    Reginald Valdez; Fiscal Year: 1999
    ..Davis (a professor who has interests in immunity to lentiviruses and hemoparasites and developed the specific anti-lymphocyte monoclonal antibodies described in ..
  67. Characterization of Innate immune receptors
    Detlef Schuppan; Fiscal Year: 2009
    ..This results in intestinal Th1 T cell activation and mucosal destruction (adaptive immunity)...
    JONATHAN RAVDIN; Fiscal Year: 1999
    ..before work can proceed on development of an amebiasis vaccine we must gain a further understanding of natural immunity to this parasite...
  69. Immunity to Oral Candidiasis
    SARAH GAFFEN; Fiscal Year: 2009
    ..The defense mechanisms that limit oral Candida in normal individuals cover the spectrum of innate and acquired immunity. Of late, much emphasis has been on CD4+ T cells due to the strikingly high incidence of OPC in HIV+ individuals...
    Danuta Kozbor; Fiscal Year: 2001
    ..An important area of induction of cellular immunity to HIV that has not been much studied is the ability to induce CTL and humoral responses at mucosal surfaces...
  71. GM-CSF secreting tumor cell vaccines to enhance post-transplant anti-CLL immunity
    Catherine Wu; Fiscal Year: 2009
    ..From these observations, we hypothesize that anti-CLL immunity can be further boosted by immunizing post-transplant patients with leukemia antigens combined with an adjuvant...
  72. Chronic alcohol and pulmonary immunity
    Kevin L Legge; Fiscal Year: 2010
    ..lesions within the pulmonary adaptive immune response in chronic alcoholics could lead to methodologies to boost immunity to this Important human pathogen...
    Sara Lustigman; Fiscal Year: 2001
    ..Previous studies have provided evidence that naturally acquired immunity against O. volvulus infection can occur in humans...
    Harry Greenberg; Fiscal Year: 2003
    ..rotavirus gene structure and function, we still do not have a clear understanding of the basis of rotavirus immunity, virulence or host tropism...