liver regeneration

Summary

Summary: Repair or renewal of hepatic tissue.

Top Publications

  1. ncbi Liver regeneration: from myth to mechanism
    Rebecca Taub
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19004, USA
    Nat Rev Mol Cell Biol 5:836-47. 2004
  2. pmc Liver regeneration
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Cell Physiol 213:286-300. 2007
  3. ncbi Liver regeneration
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
    Hepatology 43:S45-53. 2006
  4. pmc Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
    Bi Sen Ding
    Howard Hughes Medical Institute, Ansary Stem Cell Institute, and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 468:310-5. 2010
  5. ncbi Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999
  6. pmc Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas
    George K Michalopoulos
    University of Pittsburgh, Department of Pathology, School of Medicine, S 410 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Pathol 176:2-13. 2010
  7. ncbi Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    D E Cressman
    Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
    Science 274:1379-83. 1996
  8. pmc Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
    Chang Goo Huh
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4262, Building 37, Room 4146A, Bethesda, MD 20892 4262, USA
    Proc Natl Acad Sci U S A 101:4477-82. 2004
  9. pmc Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells
    Tom K Kuo
    Institute of Biopharmaceutical Science, National Yang Ming University, Taipei, Taiwan
    Gastroenterology 134:2111-21, 2121.e1-3. 2008
  10. pmc Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad
    Kari Nichole Nejak-Bowen
    Department of Pathology, University of Pittsburgh, SOM, Pittsburgh, PA 15261, United States
    Semin Cancer Biol 21:44-58. 2011

Detail Information

Publications371 found, 100 shown here

  1. ncbi Liver regeneration: from myth to mechanism
    Rebecca Taub
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19004, USA
    Nat Rev Mol Cell Biol 5:836-47. 2004
    ..The numerous cytokine- and growth-factor-mediated pathways that are involved in regulating liver regeneration are being successfully dissected using molecular and genetic approaches...
  2. pmc Liver regeneration
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Cell Physiol 213:286-300. 2007
    b>Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types...
  3. ncbi Liver regeneration
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
    Hepatology 43:S45-53. 2006
    During liver regeneration after partial hepatectomy, normally quiescent hepatocytes undergo one or two rounds of replication to restore the liver mass by a process of compensatory hyperplasia...
  4. pmc Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
    Bi Sen Ding
    Howard Hughes Medical Institute, Ansary Stem Cell Institute, and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 468:310-5. 2010
    ..endothelial cells, which through the release of angiocrine trophogens initiate and sustain liver regeneration induced by 70% partial hepatectomy...
  5. ncbi Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999
    ..but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the ..
  6. pmc Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas
    George K Michalopoulos
    University of Pittsburgh, Department of Pathology, School of Medicine, S 410 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Pathol 176:2-13. 2010
    b>Liver regeneration after partial hepatectomy is one of the most studied models of cell, organ, and tissue regeneration...
  7. ncbi Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    D E Cressman
    Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
    Science 274:1379-83. 1996
    b>Liver regeneration stimulated by a loss of liver mass leads to hepatocyte and nonparenchymal cell proliferation and rapid restoration of liver parenchyma...
  8. pmc Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
    Chang Goo Huh
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4262, Building 37, Room 4146A, Bethesda, MD 20892 4262, USA
    Proc Natl Acad Sci U S A 101:4477-82. 2004
    ..These studies provide direct genetic evidence in support of the critical role of c-met in efficient liver regeneration and suggest that disruption of c-met affects primarily hepatocyte survival and tissue remodeling.
  9. pmc Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells
    Tom K Kuo
    Institute of Biopharmaceutical Science, National Yang Ming University, Taipei, Taiwan
    Gastroenterology 134:2111-21, 2121.e1-3. 2008
    ..The aim of this study was to critically analyze the various parameters governing the success of bone marrow-derived mesenchymal stem cell-based therapy for treatment of liver diseases...
  10. pmc Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad
    Kari Nichole Nejak-Bowen
    Department of Pathology, University of Pittsburgh, SOM, Pittsburgh, PA 15261, United States
    Semin Cancer Biol 21:44-58. 2011
    ..Could β-catenin signaling be one such pathway that may be redundant in regeneration and indispensible in HCC in a subset of cases?..
  11. ncbi Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells
    Wen Yang
    International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, PR China
    Cancer Res 68:4287-95. 2008
    ....
  12. ncbi Isolation and characterization of a stem cell population from adult human liver
    Maria Beatriz Herrera
    Department of Internal Medicine, University of Torino, Torino, Italy
    Stem Cells 24:2840-50. 2006
    ..In conclusion, we here identified a pluripotent progenitor population in adult human liver that could provide a basis for cell therapy strategies...
  13. pmc Liver stem cells and hepatocellular carcinoma
    Lopa Mishra
    Laboratory of Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Hepatology 49:318-29. 2009
    ..This review provides a rationale for detecting and analyzing tumor stem cells as one of the most effective ways to treat cancers such as HCC...
  14. pmc Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
    Stefan Hoehme
    Interdisciplinary Centre for Bioinformatics IZBI, University of Leipzig, Härtelstrasse 16 18, D 04107 Leipzig, Germany
    Proc Natl Acad Sci U S A 107:10371-6. 2010
    ..As a proof of principle, we reconstructed and modeled liver regeneration in mice after damage by CCl(4), a prototypical inducer of pericentral liver damage...
  15. pmc A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration
    Raymond Ng
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, California 94143, USA
    J Clin Invest 122:1097-108. 2012
    ..Recently, it has been found that miR-21 expression is rapidly induced in rodent hepatocytes during liver regeneration after two-thirds partial hepatectomy (2/3 PH)...
  16. ncbi miRNA regulation of liver growth after 50% partial hepatectomy and small size grafts in rats
    Xiaoli Chen
    Department of Internal Medicine, Transplant Research Program, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Transplantation 91:293-9. 2011
    ..The aim of this study is to identify critical miRNA species that modulate the growth of small grafts and the remaining livers after partial hepatectomy (PH)...
  17. pmc MicroRNAs control hepatocyte proliferation during liver regeneration
    Guisheng Song
    Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA
    Hepatology 51:1735-43. 2010
    ..However, whether miRNAs regulate hepatocyte proliferation during liver regeneration is unknown...
  18. ncbi Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration
    Yuichiro Miyaoka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Curr Biol 22:1166-75. 2012
    ..for about 80% of liver weight, so we investigate how the number and size of hepatocytes contribute to liver regeneration in mice...
  19. ncbi MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration
    Qinggong Yuan
    Cluster of Excellence REBIRTH, Hannover Medical School, Hannover, Germany
    Hepatology 57:299-310. 2013
    The tightly controlled replication of hepatocytes in liver regeneration and uncontrolled proliferation of tumor cells in hepatocellular carcinoma (HCC) are often modulated by common regulatory pathways...
  20. ncbi Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 312:233-6. 2006
    ..Here, we identify a role for nuclear receptor-dependent bile acid signaling in normal liver regeneration. Elevated bile acid levels accelerate regeneration, and decreased levels inhibit liver regrowth, as does the ..
  21. pmc Mir-34a is upregulated during liver regeneration in rats and is associated with the suppression of hepatocyte proliferation
    Huan Chen
    Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China
    PLoS ONE 6:e20238. 2011
    ..This study aims to explore the effect of miR-34a in hepatocyte proliferation and its potential role in liver regeneration termination.
  22. pmc Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration
    J C Hsu
    Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104 6145
    Mol Cell Biol 12:4654-65. 1992
    ..Thus, through complex interactions among LRF-1, JunB, c-Jun, and c-Fos, control of delayed gene expression may be established for extended times during the G1 phase of hepatic growth...
  23. pmc Stem cells and liver regeneration
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Gastroenterology 137:466-81. 2009
    ..The extent to which liver stem cells mediate liver regeneration has been hotly debated...
  24. pmc Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance
    Tobias A Beyer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO J 27:212-23. 2008
    ..To determine the effect of oxidative stress on liver regeneration and to identify the underlying signaling pathways, we studied liver repair in mice lacking the Nrf2 ..
  25. pmc The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas
    S L Feng
    Department of Vascular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    Am J Pathol 156:1253-61. 2000
    ..Furthermore, the murine Fn14 gene is rapidly induced during liver regeneration in vivo and is expressed at high levels in the hepatocellular carcinoma nodules that develop in the c-myc/..
  26. pmc Met provides essential signals for liver regeneration
    Malgorzata Borowiak
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin Buch, Germany
    Proc Natl Acad Sci U S A 101:10608-13. 2004
    ..Here, we use conditional mutagenesis in mice to analyze the function of Met during liver regeneration, using the Mx-cre transgene to introduce the mutation in the adult...
  27. ncbi Caveolin-1 is essential for liver regeneration
    Manuel A Fernandez
    Departament de Biologia Cellular, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
    Science 313:1628-32. 2006
    b>Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division...
  28. pmc Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
    Bi Sen Ding
    1 Ansary Stem Cell Institute, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA 2
    Nature 505:97-102. 2014
    ..or traumatic damage to the liver is frequently associated with aberrant healing (fibrosis) that overrides liver regeneration. The mechanism by which hepatic niche cells differentially modulate regeneration and fibrosis during liver ..
  29. ncbi Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice
    Run Zhe Shu
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Lab Invest 89:1043-52. 2009
    b>Liver regeneration is a very complex and well-orchestrated process associated with signaling cascades involving cytokines, growth factors, and metabolic pathways...
  30. pmc Robust cellular reprogramming occurs spontaneously during liver regeneration
    Kilangsungla Yanger
    Department of Medicine, Gastroenterology Division
    Genes Dev 27:719-24. 2013
    ..These results provide direct evidence that mammalian regeneration prompts extensive and dramatic changes in cellular identity under injury conditions...
  31. pmc Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
    John P Iredale
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 117:539-48. 2007
    ..This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ...
  32. ncbi MicroRNA profiling in murine liver after partial hepatectomy
    Ioannis Chaveles
    Surgical Department, Medical School, University of Patras, 26504 Patras, Greece
    Int J Mol Med 29:747-55. 2012
    ..control mice (L0) and compared them with the corresponding levels in liver tissue 12 h after liver regeneration induced by 2/3 partial hepatectomy (L12)...
  33. pmc Hepatic stellate cells' involvement in progenitor-mediated liver regeneration
    Dana G Pintilie
    Department of Pathology, Immunology and Laboratory Medicine, Program for Stem Cell Biology and Regenerative Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0275, USA
    Lab Invest 90:1199-208. 2010
    ..7-fold in the L-cysteine-treated animals. These data indicate that the activation of hepatic stellate cells is required for an appropriate oval cell response to 2AAF/PH...
  34. pmc Transforming growth factor-beta1 protein, proliferation and apoptosis of oval cells in acetylaminofluorene-induced rat liver regeneration
    D Y Park
    Department of Pathology, College of Medicine, Pusan National University, Korea
    J Korean Med Sci 14:531-8. 1999
    ..that TGF-beta1 produced by HSCs is intimately associated with proliferation and apoptosis of oval cells, and plays a role in the cessation of oval cell activation and remodeling of liver parenchyma in 2-AAF induced liver regeneration.
  35. ncbi Activation of human liver sinusoidal endothelial cell by human platelets induces hepatocyte proliferation
    Takuya Kawasaki
    Department of Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    J Hepatol 53:648-54. 2010
    We previously reported that platelets promote hepatocyte proliferation. In this study, we focused on the role of platelets in liver sinusoidal endothelial cells (LSECs) in addition to their role in hepatocyte in liver regeneration.
  36. pmc Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid
    Rui E Castro
    Research Institute for Medicines and Pharmaceutical Sciences, Univ of Lisbon, Portugal
    Am J Physiol Gastrointest Liver Physiol 299:G887-97. 2010
    ..In addition, we have previously shown that ursodeoxycholic acid (UDCA) modulates mRNA levels during liver regeneration. Bile acids are also homeotrophic sensors of functional hepatic capacity...
  37. ncbi Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Hepatology 39:1477-87. 2004
  38. ncbi Progenitor cells in liver regeneration: molecular responses controlling their activation and expansion
    Eric Santoni-Rugiu
    Department of Pathology, Herlev University Hospital, Denmark
    APMIS 113:876-902. 2005
    ....
  39. pmc The EGF receptor is required for efficient liver regeneration
    Anuradha Natarajan
    Department of Dermatology, Division of Immunology, Allergy, and Infectious Diseases, and Institute for Cancer Research, Department of Medicine 1, Vienna Competence Center, Medical University of Vienna, Lazarettgasse 19, A 1090 Vienna, Austria
    Proc Natl Acad Sci U S A 104:17081-6. 2007
    ..b>Liver regeneration was delayed in the mutants because of reduced hepatocyte proliferation...
  40. ncbi Annexin A3 expression increases in hepatocytes and is regulated by hepatocyte growth factor in rat liver regeneration
    Mizuho Harashima
    Department of Nutrition and Physiology, Nihon University College of Bioresource Sciences, Kameino Fujisawa, Japan
    J Biochem 143:537-45. 2008
    ..However, no information is available on its expression and role in rat liver regeneration. In the present study, AnxA3 expression was investigated to determine whether it also plays a role in the ..
  41. pmc Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
    Y Yamada
    Department of Pathology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 94:1441-6. 1997
    The mechanisms that initiate liver regeneration after resection of liver tissue are not known...
  42. pmc Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration
    Jingmin Shu
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Hepatology 54:609-19. 2011
    ..We carried out genomewide microRNA (miRNA) microarray studies during liver regeneration in rats after 70% partial hepatectomy (PH) at early and mid time points to more thoroughly understand their ..
  43. ncbi Down-regulation of miR-23b may contribute to activation of the TGF-β1/Smad3 signalling pathway during the termination stage of liver regeneration
    Bin Yuan
    Department of Biochemistry and Molecular Biology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    FEBS Lett 585:927-34. 2011
    MicroRNAs (miRNAs) are known to play important roles in liver regeneration, although the role of miRNAs associated with the termination of liver regeneration is not as well studied...
  44. ncbi Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury
    Isabelle A Leclercq
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, NSW, Australia
    Gastroenterology 124:1451-64. 2003
    Profound impairment of liver regeneration in rodents with dysfunctional leptin signaling has been attributed to non-alcohol-induced fatty liver disorders (NAFLD)...
  45. ncbi Hematopoietic stem cells convert into liver cells within days without fusion
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Nat Cell Biol 6:532-9. 2004
    ..Notably, liver function was restored 2-7 d after transplantation. We conclude that HSCs contribute to the regeneration of injured liver by converting into functional hepatocytes without fusion...
  46. ncbi Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    E Lagasse
    StemCells, 525 Del Rey Avenue, Suite C, Sunnyvale, California 94085, USA
    Nat Med 6:1229-34. 2000
    ....
  47. ncbi Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration
    Shuk Pik Lam
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 16:1195-206. 2010
    ..In conclusion, transplantation of MSCs promotes cell proliferation and organ repair, and activation of IL-6/gp130-mediated STAT3 signaling pathway via soluble IL-6 receptor is crucial in hepatic differentiation of MSCs...
  48. pmc Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice
    Silvia Espejel
    Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California 94143, USA
    J Clin Invest 120:3120-6. 2010
    ..whether iPS cell-derived hepatocytes have both the functional and proliferative capabilities needed for liver regeneration in mice with fumarylacetoacetate hydrolase deficiency...
  49. ncbi Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy
    T Sakamoto
    Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 29:403-11. 1999
    ..However, this robust response generates superfluous hepatocytes, which are eliminated via apoptosis, similar to many other processes involving organ growth...
  50. pmc MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-kappaB signaling
    Rebecca T Marquez
    University of Iowa School of Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 298:G535-41. 2010
    During liver regeneration, normally quiescent liver cells reenter the cell cycle, nonparenchymal and parenchymal cells divide, and proper liver architecture is restored...
  51. ncbi Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
    Ahmed Zaid
    Laboratorie of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, affiliated to the University of Montreal, Montreal, Quebec, Canada
    Hepatology 48:646-54. 2008
    ..However, lipid accumulation in hepatocytes of these mice was markedly reduced under both chow and high-cholesterol diets, revealing that PCSK9 deficiency confers resistance to liver steatosis...
  52. pmc Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1
    Kirsten C Sadler
    Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:1570-5. 2007
    ..By developing a methodology to perform PH on adult zebrafish, we found that liver regeneration inuhrf1+/- adult animals is impaired...
  53. ncbi Cytokines, STATs and liver disease
    Bin Gao
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 2:92-100. 2005
    ..This article reviews the biological significance of STAT1, 2, 3, 4, 5, 6 in hepatic functions and diseases...
  54. ncbi The role of hepatocytes and oval cells in liver regeneration and repopulation
    Nelson Fausto
    Department of Pathology, University of Washington, Seattle, WA, USA
    Mech Dev 120:117-30. 2003
    ..This growth process, as well as that following acute chemical injury is known as liver regeneration, although growth takes place by compensatory hyperplasia rather than true regeneration...
  55. ncbi Advances in the regulation of liver regeneration
    Changku Jia
    Department of Hepatobiliary Surgery, Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, China
    Expert Rev Gastroenterol Hepatol 5:105-21. 2011
    b>Liver regeneration is known to be a process involving highly organized and ordered tissue growth triggered by the loss of liver tissue, and remains a fascinating topic...
  56. pmc Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase
    Udayan Apte
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 50:844-51. 2009
    Following liver regeneration after partial hepatectomy, liver grows back precisely to its original mass and does not exceed it. The mechanism regulating this "hepatostat" is not clear and no exceptions have been found to date...
  57. ncbi Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
    Daan van Poll
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA, USA
    Hepatology 47:1634-43. 2008
    ..FHF is usually accompanied by massive hepatocellular death with compensatory liver regeneration that fails to meet the cellular losses...
  58. pmc Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
    M Kasim Diril
    Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research ASTAR, Republic of Singapore 138673
    Proc Natl Acad Sci U S A 109:3826-31. 2012
    ..Interestingly, liver-specific deletion of Cdk1 is well tolerated, and liver regeneration after partial hepatectomy is not impaired, indicating that regeneration can be driven by cell growth without ..
  59. pmc New concepts in liver regeneration
    Kimberly J Riehle
    Department of Surgery, University of Washington, Seattle, USA
    J Gastroenterol Hepatol 26:203-12. 2011
    ..This review traces the path that has been taken over the last few decades in the study of liver regeneration, highlights new concepts in the field, and discusses the challenges that still stand between us and clinical ..
  60. ncbi Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly
    M R Alison
    Centre for Diabetes and Metabolic Medicine, St Bartholomew s Hospital and the London School of Medicine and Dentistry, London, UK
    J Pathol 217:282-98. 2009
    ..HCC may have its origins in either hepatocytes or HPCs, and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells...
  61. ncbi The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis
    Pei Chun Tsai
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Liver Transpl 15:484-95. 2009
    ..Our findings suggest that xenogeneic transplantation of HUMSCs is a novel approach for treating liver fibrosis and may be a promising therapeutic intervention in the future...
  62. pmc A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice
    Songqing He
    Department of Microbiology and Immunology, Darby Children s Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Clin Invest 119:2304-16. 2009
    ..an inhibitor of C3 activation) provided protection from hepatic IRI, and while C3 deficiency also impaired liver regeneration following partial hepatectomy (PHx), the effect of CR2-Crry in this context was dose dependent...
  63. ncbi Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London
    Juliana Puppi
    Institute of Liver Studies, King s College London School of Medicine at King s College Hospital, London, UK
    Cell Transplant 21:1-10. 2012
    ....
  64. pmc LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis
    Jennifer Dahan
    Unité d Oncogenèse et Virologie Moléculaire, Institut Pasteur, Paris, France
    Mol Cell Biol 33:3299-308. 2013
    ..TNF and IL-6 are the key cytokines that prime liver regeneration after hepatic injury...
  65. pmc Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration
    Nian Ling Zhu
    Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis and Department of Pathology, Keck School of Medicine, The University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 287:10355-67. 2012
    ..These results suggest novel roles of HSC-derived DLK1 in activating HSCs via epigenetic Pparγ repression and participating in liver regeneration and development in a manner involving the mesenchymal-epithelial interaction.
  66. ncbi Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury
    Cornelia S Viebahn
    School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Australia
    J Hepatol 53:500-7. 2010
    ..A number of pro-inflammatory factors were identified in cytokine knockout mice in which the LPC response was attenuated but neither the mechanism nor the producing cells are known...
  67. pmc Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice
    Tsuyoshi Ishikawa
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4262, USA
    Hepatology 55:1215-26. 2012
    ..Here, we directly addressed the role of c-Met in stem-cell-mediated liver regeneration by utilizing mice harboring c-met floxed alleles and Alb-Cre or Mx1-Cre transgenes...
  68. pmc Down-regulation of microRNA-26a promotes mouse hepatocyte proliferation during liver regeneration
    Jian Zhou
    Organ Transplant Center, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e33577. 2012
    Inadequate liver regeneration (LR) is still an unsolved problem in major liver resection and small-for-size syndrome post-living donor liver transplantation...
  69. ncbi Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice
    Iker Uriarte
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, Clinic University of Navarra and CIBERehd, Pamplona, Spain
    Gut 62:899-910. 2013
    ..and morbidity after partial hepatectomy (PH), yet bile acids (BAs) are emerging as important mediators of liver regeneration. Fibroblast growth factor 15 (Fgf15, human FGF19) is a BA-induced ileum-derived enterokine that governs BA ..
  70. ncbi Secreted factors of human liver-derived mesenchymal stem cells promote liver regeneration early after partial hepatectomy
    Suomi M G Fouraschen
    Laboratory of Experimental Transplantation and Intestinal Surgery, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stem Cells Dev 21:2410-9. 2012
    Rapid liver regeneration is required after living-donor liver transplantation and oncologic liver resections to warrant sufficient liver function and prevent small-for-size syndrome...
  71. pmc The hepatic stem cell niche: identification by label-retaining cell assay
    Reiichiro Kuwahara
    Department of Medicine, Division of Digestive Diseases, Beth Israel Medical Center Albert Einstein College of Medicine, New York, NY 10003, USA
    Hepatology 47:1994-2002. 2008
    ....
  72. ncbi Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases
    Lorenzo Capussotti
    Divisione Chirurgia Oncologica, Istituto per la Ricerca e la Cura del Cancro, Strada Provinciale 142 km 3, 95, 10060 Candiolo, Italy
    Arch Surg 143:978-82; discussion 982. 2008
    ..Portal vein ligation has been suggested to be less effective than embolization in inducing hypertrophy of the remnant liver...
  73. pmc Analysis of the role of hepatic PPARγ expression during mouse liver regeneration
    Vered Gazit
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hepatology 56:1489-98. 2012
    ..These observations suggest that alterations in metabolism in response to hepatic insufficiency promote liver regeneration. Hepatic expression of the peroxisome proliferator-activated receptor gamma (PPARγ) influences fat ..
  74. pmc Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference
    Shirish Paranjpe
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 45:1471-7. 2007
    Hepatocyte growth factor (HGF) and its receptor c-Met are involved in liver regeneration. The role of HGF and c-Met in liver regeneration in rat following two-thirds partial hepatectomy (PHx) was investigated using RNA interference to ..
  75. ncbi Progenitor cells in diseased human liver
    Tania A Roskams
    Laboratory of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Semin Liver Dis 23:385-96. 2003
    ..The factors that govern human hepatic progenitor cell activation and differentiation are beginning to be identified...
  76. ncbi Mesenchymal stem cells showed the highest potential for the regeneration of injured liver tissue compared with other subpopulations of the bone marrow
    Kyung Ah Cho
    Department of Microbiology, Ewha Womans University College of Medicine, Ewha Medical Research Center, Seoul, Republic of Korea
    Cell Biol Int 33:772-7. 2009
    ....
  77. pmc Chronic ethanol feeding alters miRNA expression dynamics during liver regeneration
    Rachael P Dippold
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Alcohol Clin Exp Res 37:E59-69. 2013
    ..Adaptation to chronic ethanol (EtOH) treatment of rats results in a changed functional state of the liver and greatly inhibits its regenerative ability, which may contribute to the progression of alcoholic liver disease...
  78. pmc Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats
    Lin Wang
    Division of Gastrointestinal and Liver Disease and University of Southern California Research Center for Liver Disease, Los Angeles, California 90033, USA
    J Clin Invest 122:1567-73. 2012
    ..in hepatocyte growth factor (HGF) in liver sinusoidal endothelial cells (LSECs) are thought to drive liver regeneration. However, in contrast to endothelial progenitor cells, mature LSECs express little HGF...
  79. ncbi Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration
    Z Z Huang
    Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, USC School of Medicine, Los Angeles, California 90033, USA
    FASEB J 15:19-21. 2001
    Increased glutathione (GSH) level occurs early during liver regeneration and in many drug and/or radiation-resistant tumors. Whether GSH level is elevated in liver cancer is unknown...
  80. ncbi Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
    C Yu
    Department of Biochemistry and Biophysics, Texas A and M University, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030 3303, USA
    J Biol Chem 275:15482-9. 2000
    ....
  81. pmc Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver
    Axel Behrens
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    EMBO J 21:1782-90. 2002
    ..After partial hepatectomy, half of the mutants died and liver regeneration was impaired. This phenotype was not present in mice lacking the N-terminal phosphorylation sites of c-Jun...
  82. pmc Immortalization of a primate bipotent epithelial liver stem cell
    Jean Etienne Allain
    Equipe Mixte INSERM 00 20, Laboratoire de Transfert de Gènes dans le Foie Applications Thérapeutiques, Hopital Antoine Beclere, 157 rue de la Porte de Trivaux, 92141 Clamart, France
    Proc Natl Acad Sci U S A 99:3639-44. 2002
    b>Liver regeneration after partial hepatectomy results primarily from the simple division of mature hepatocytes...
  83. ncbi Molecular process in acute liver injury and regeneration induced by carbon tetrachloride
    Makoto Taniguchi
    Division of Molecular Biology, Department of Molecular and Cellular Biology, School of Life Sciences, Tottori University Faculty of Medicine, 86 Nishimachi, Yonago 683 8503, Japan
    Life Sci 75:1539-49. 2004
    ..Interestingly, ERK2 was transiently activated at 3 h CCl4-treatment. These observations suggested that hepatotoxin by CCl4-injection concomitantly induces both processes in acute injury and liver regeneration.
  84. ncbi Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury
    Hiroyuki Yoneyama
    Laboratory of Stem Cell Dynamism, Stelic Institute of Regenerative Medicine, Stelic Institute and Co, 1 9 15 Higashi azabu, Mihato ku, Tokyo, Japan
    Med Mol Morphol 40:191-7. 2007
    ..Thus, CXCL10 can be a novel therapeutic target for acute hepatocellular damage by regulating liver tissue remodeling...
  85. ncbi Comparison of gene expression in hepatocellular carcinoma, liver development, and liver regeneration
    Tingting Li
    Department of Biomedical Informatics, Peking University Health Science Center, 38 Xueyuan Rd, Beijing, 100191, China
    Mol Genet Genomics 283:485-92. 2010
    ..of liver cells can be observed in hepatocarcinogenesis, at different stages of liver development, and during liver regeneration after an injury...
  86. pmc Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old
    Dilek Colak
    Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Mol Cancer 9:146. 2010
    ..To identify distinct molecular mechanisms for early HCC we developed a rat model of liver regeneration post-hepatectomy, as well as liver cells undergoing malignant transformation and compared them to normal ..
  87. pmc Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice
    Bowen Liu
    Division of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hepatology 52:1060-7. 2010
    ..in comparison with their nontransgenic littermates but had a suppressed rate of hepatocyte proliferation and liver regeneration after partial hepatectomy...
  88. ncbi Role of peroxisome proliferator-activated receptor-gamma (PPARgamma) during liver regeneration in rats
    Yoshio Yamamoto
    Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, Enyacho, Izumo, Japan
    J Gastroenterol Hepatol 23:930-7. 2008
    ..Several reports have shown that PPARgamma activation induced cell-cycle arrest and apoptosis in tumor cells. We investigated the role of the PPARgamma/ligand system and the effect of the PPARgamma agonist during liver regeneration.
  89. ncbi Vitamin D3 up-regulated protein 1 deficiency accelerates liver regeneration after partial hepatectomy in mice
    Hyo Jung Kwon
    Biomedical Mouse Resource Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea
    J Hepatol 54:1168-76. 2011
    b>Liver regeneration is a complicated process involving a variety of interacting factors...
  90. ncbi Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis
    M Shimizu
    Department of Pathology, Gifu University School of Medicine, Gifu, Japan
    Hepatology 33:569-76. 2001
    ..a delay in the expression of both mature HGF and phosphorylated c-Met, accompanying a normal rate of liver regeneration. In contrast, PAI-1(-/-) mice showed accelerated liver regeneration; mature HGF emerged as early as 3 hours, ..
  91. ncbi Interleukin 6 is important for survival after partial hepatectomy in mice
    Alex Blindenbacher
    Department of Research, University Hospital Basel, Basel, Switzerland
    Hepatology 38:674-82. 2003
    ..When we analyzed these mice, we found an intact liver regeneration and no indication of a block in cell cycle reentry...
  92. ncbi Liver regeneration
    Leonidas G Koniaris
    Department of Surgery, University of Rochester School of Medicine, Rochester, NY, USA
    J Am Coll Surg 197:634-59. 2003
  93. ncbi Regulation of mammalian cell cycle progression in the regenerating liver
    Anuradha Chauhan
    Institute for Theoretical Biology, Humboldt University, Invalidenstrasse 43, 10115 Berlin, Germany
    J Theor Biol 283:103-12. 2011
    ..hepatocytes), which undergo one or two rounds of synchronous circadian-clock gated cell divisions during liver regeneration, after partial hepatectomy (PH)...
  94. ncbi Nutritional modulation of liver regeneration by carbohydrates, lipids, and amino acids: a review
    M Holecek
    Department of Physiology, Charles University School of Medicine, Hradec Kralove, Czech Republic
    Nutrition 15:784-8. 1999
    ..that glucose administration inhibits, whereas infusion of a lipid emulsion can enhance, the rate of liver regeneration. However, the inhibitory effect of glucose on liver regeneration is not observed when glucose is ..
  95. ncbi Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration
    Manuel Alejandro Fernández-Rojo
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
    Hepatology 55:1574-84. 2012
    ..conditions CAV1 expression in mouse tissues is necessary to guarantee an efficient progression of liver regeneration and mouse survival after partial hepatectomy...
  96. ncbi The effects of hyperbaric oxygen treatment on oxidant and antioxidants levels during liver regeneration in rats
    Tülin Ayşe Ozden
    Institute of Child Health, Trace Element Unit, Istanbul University, Capa, Turkey
    Tohoku J Exp Med 203:253-65. 2004
    ..study, we investigated a possible beneficial effect of HBO therapy on oxidant and antioxidants levels during liver regeneration. To conduct this study, seventy percent hepatectomy was performed on forty-eight Spraggue-Dawley rats and ..
  97. pmc Liver regeneration: alternative epithelial pathways
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Biochem Cell Biol 43:173-9. 2011
    ..Mechanistic analysis of these pathways has implications for liver biology and for potential therapeutic modalities in human liver disease...
  98. pmc Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice
    Sonya V Iverson
    Department of Immunology and Infectious Disease, Animal Resources Center, Montana State University, Bozeman, MT 59718, USA
    Hepatology 54:655-63. 2011
    ..In comparison with resting adult livers, the relative abundance of these newborn hepatocytes was elevated 3.7-fold in the growing livers of juveniles and 8.6-fold during liver regeneration after partial hepatectomy in adults.
  99. pmc Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts
    Zhi Zhong
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Liver Transpl 16:181-90. 2010
    ..Together, these data show that TGF-beta is responsible, at least in part, for the defective liver regeneration in small-for-size grafts by activating the Smad signaling pathway.
  100. ncbi Liver cancer stem cells: implications for a new therapeutic target
    Terence Kin Wah Lee
    Liver Cancer and Hepatitis Research Laboratory and S H Ho Foundation Research Laboratories, Department of Pathology, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    Liver Int 29:955-65. 2009
    ..We will also summarize the current CSC markers in HCC and discuss their relevance to the treatment of this deadly disease...
  101. ncbi Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice
    Hisao Ezaki
    Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2 2, K1, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 378:68-72. 2009
    ..However, its role in liver regeneration remains unclear. The aim of this study was to determine the role of adiponectin in liver regeneration...

Research Grants79

  1. microRNA Uncoupling of Protein and Transcript Expression in Liver Regeneration
    CLIFFORD JOHN STEER; Fiscal Year: 2010
    ..Our hypothesis is that microRNAs are required for liver regeneration and primarily responsible for the observed uncoupling of protein and transcript expression after PH...
  2. Med1 in Liver Metabolism, Regeneration and Cancer
    Janardan K Reddy; Fiscal Year: 2013
    ..Med1 also controls liver regeneration and the development of hepatocellular carcinoma (HCC), in that hepatocytes lacking Med1 fail to regenerate ..
  3. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..ask: How does the absence of hepatic retinoid stores influence alcohol-induced liver disease development and liver regeneration? These investigations will involve the use of Lrat-/- mice to explore the role that hepatic retinoid stores ..
  4. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..identifies areas such as understanding cellular and molecular processes of normal liver cell functioning;liver regeneration and development;and hepatic fibrosis;to make an overall impact on liver health...
  5. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
    ..In a best-case scenario, such therapeutics will accelerate liver regeneration and preclude the need for transplantation;in the most severe cases, they will serve as a "hepatic bridge" ..
  6. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    DESCRIPTION (provided by the applicant): Incomplete liver regeneration is an obstacle to recovery from liver disease and for patients who receive grafts through living-donor liver transplantation...
  7. IKKbeta:Bi-Functional Regulator of Hepatocyte Proliferation
    Hyam L Leffert; Fiscal Year: 2010
    ..by applicant): The long-term goals of this proposal are directed towards understanding mechanisms of liver regeneration and hepatocarcinogenesis...
  8. USC Research Center for Liver Disease
    Neil Kaplowitz; Fiscal Year: 2013
    ..Current projects include studies of: a) farnesoid X receptor, bile acids and liver regeneration;b) the role of Myc-max and Mnt-max in regulation of p53 and cyclin D1 by toxic bile acid;c) salvage of short ..
  9. Role of Hepatitis B virus X protein in HBV replication
    Michael J Bouchard; Fiscal Year: 2011
    ..Although continual immune-mediated destruction of HBV-infected hepatocytes and concomitant liver regeneration are important factors in the development of HBV-associated HCC, HBV proteins such as the HBV X protein (HBx) ..
  10. Hepatitis B virus X protein modulation of calcium signaling in HCC development
    JESSICA GARNER; Fiscal Year: 2013
    ..are thought to involve the immune-mediated destruction of HBV-infected hepatocytes and compensatory liver regeneration as well as activities of the multifunctional HBV X protein (HBx)...
  11. Mechanisms of oval cell activation and differentiation
    Bryon E Petersen; Fiscal Year: 2013
    ..The overarching question of this research proposal is;which systemic signals regulate stem cell mediated liver regeneration and what molecular mechanisms underlie this regulation? The proposed research will identify the role and ..
  12. C/EBP beta SIGNALS HEPATOCYTE PROLIFERATION AND SURVIVAL
    Mario Chojkier; Fiscal Year: 2012
    ..These studies are relevant to the hepatocyte proliferation and survival characteristic of many physiological and pathological conditions, including hepatocellular injury, liver regeneration and hepatocellular carcinoma.
  13. ROLE OF WNT SIGNALING IN CHRONIC ALCOHOLIC LIVER DISEASE
    Miran Kim; Fiscal Year: 2013
    ..of hepatic insulin/IGF resistance is, in large measure, responsible for ethanol-mediated impairments in liver regeneration and repair following injury...
  14. Molecular mechanisms of C/EBP alpha mediated growth arrest
    Nikolai A Timchenko; Fiscal Year: 2013
    ..the inhibitory activity of C/EBP1 when livers proliferate;and the role of C/EBP1 in termination of liver regeneration when liver reaches original size...
  15. Role of Uhrf1 in Liver Development, Regeneration and Carciogenesis
    Chinweike Ukomadu; Fiscal Year: 2013
    ..By forward genetic screening in zebrafish embryos combined with functional studies on liver regeneration in adults and expression analysis of human HCC samples, we have found that the ubiquitin-like, containing ..
  16. Investigation of the liver progenitor cell niche using CK19 lineage tracing
    EUGENE SCOTT SWENSON; Fiscal Year: 2011
    ..Aim 2: Determine the role of intrahepatic CK19+ hepatic progenitor cells during liver regeneration after injury by 1) partial hepatectomy and 2) acute acetaminophen injury...
  17. Trafficking of the EGF receptor to the nucleus: Mechanisms and Effects
    Michael H Nathanson; Fiscal Year: 2013
    ..Chronic hepatocellular damage can lead to impaired regulation of liver regeneration, which results in hepatocellular carcinoma, one of the most common malignancies in the world...
  18. Complement and cytokine network in liver regeneration
    John D Lambris; Fiscal Year: 2011
    ..Recent studies in our laboratory have demonstrated the involvement of complement in the priming phase of liver regeneration. The regenerative response is impaired after partial hepatectomy (PHx) and carbon tetrachloride (CCI4) ..
  19. ENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESIS
    NICHOLAS DAVIDSON; Fiscal Year: 2013
    ..susceptibility?" Germline deletion of Acf is embryonic lethal and heterozygous Acf mice demonstrate delayed liver regeneration following partial hepatectomy (PH)...
  20. Function of metal transporter ZIP14 as regulated by proinflammatory stimuli
    Robert J Cousins; Fiscal Year: 2013
    ..2. Evaluate the involvement of ZIP14 in murine liver regeneration and during inflammatory responses. 3...
  21. Systems analysis of TGFbeta signaling and SnoN function in liver
    Kunxin Luo; Fiscal Year: 2013
    ..is known to be a potent inhibitor of hepatocyte proliferation and is also the critical negative regulator of liver regeneration. In primary hepatocytes, TGF2 signals through Smad2 and Smad4 proteins...
  22. Ah Receptor Anatomy: Implications for Dioxin Toxicity
    CORNELIS JOHAN ELFERINK; Fiscal Year: 2011
    ..of cyclin-dependent kinase 2 (CDK2) inhibi- ion and plasminogen activator inhibitor-1 (PAI-1) expression on liver regeneration. TCDD alters CDK2 activity and PAI-1 expression during liver regeneration, representing distinct ..
  23. Multifunctional Printed Scaffolds for Enhancing Hepatocyte Viability and Function
    Ramille N Shah; Fiscal Year: 2013
    ..Ramille Shah, is to become an independent investigator and leader at the forefront of the liver regeneration field...
  24. A20 Gene Polymorphisms in LDLT
    Christiane Ferran; Fiscal Year: 2012
    ..anti- apoptotic, and anti-oxidant response to injury, and promotes hepatocyte proliferation and liver regeneration. In experimental animal models, we have shown that overexpression of A20 in the liver is protective ..
  25. Role of Bile Acids in the Initiation of Liver Regeneration
    Willscott E Naugler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This research focuses on liver regeneration and the initial triggers of this phenomenon...
  26. Matrix Metalloproteinases in Hepatic Ischemia and Reperfusion Injury
    Ana J Coito; Fiscal Year: 2013
    ..steatotic liver IRI by determining the impact of TIMP-1 deficiency on (i) liver function/preservation, (ii) liver regeneration and apoptosis, (iii) MMP activation, and on (iii) leukocyte recruitment and pro-inflammatory networks...
  27. The transcriptional basis of tumor promotion
    Joseph D Locker; Fiscal Year: 2013
    ..induced by the tumor promoter, TCPOBOP;(2) antipromotional hyperplasia induced by thyroid hormone;(3) rapid liver regeneration after partial hepatectomy (PH) in the rat; and (4) more protracted regeneration after PH in the mouse...
  28. LDLT: Diagnostic Markers of Liver Regeneration to Predict Outcomes
    Elizabeth A Pomfret; Fiscal Year: 2013
    ....
  29. Histone methyltransferase EZH2 in liver pathophysiology and carcinogenesis
    Hong Lu; Fiscal Year: 2012
    ..We found that EZH2 was markedly induced during liver regeneration, suggesting its importance for the regeneration of liver...
  30. cPLA2alpha, COX-2 and TGF-beta in Liver Cancer
    Tong Wu; Fiscal Year: 2011
    ..COX-2 transgenic and knockout mice will be crossed with the TGF-?receptor type II knockout mice to determine liver regeneration and DEN-induced hepatocarcinogenesis...
  31. The Cell-autonomous Contributions of UHRF1 to Liver Development and Regeneration
    Vinitha Jacob; Fiscal Year: 2013
    ..Thus, uhrf1 is required for hepatocyte proliferation during liver development and liver regeneration. However, it is not clear whether the failure of hepatocyte proliferation during the above processes is due ..
  32. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2013
    ..In stem cell-aided liver regeneration, progeny of the stem cells multiply in an amplification compartment composed of hepatic oval cells...
  33. Hhex-a Homeobox Gene Necessary for Liver Development
    Clifford W Bogue; Fiscal Year: 2010
    ..will also identify new genetic pathways operative in liver development, which has important implications for liver regeneration and repair...
  34. Matrix Metalloproteinases in Hepatic Ischemia and Reperfusion Injury
    Ana J Coito; Fiscal Year: 2010
    ..steatotic liver IRI by determining the impact of TIMP-1 deficiency on (i) liver function/preservation, (ii) liver regeneration and apoptosis, (iii) MMP activation, and on (iii) leukocyte recruitment and pro-inflammatory networks...
  35. Ah receptor transcriptional regulation through a novel DNA binding site
    SHELLY RENEE WILSON; Fiscal Year: 2012
    ..Preliminary evidence examining TCDD induction of plasminogen activator inhibitor-1 (PAI-1), a key protein in liver regeneration, exposed a novel AhR-dependent regulatory mechanism involving DNA binding to a non- consensus XRE (NC-XRE) ..
  36. Carbohydrate-mediated platelet clearance
    KARIN MARIA HOFFMEISTER; Fiscal Year: 2013
    ..b>Liver regeneration depends on the delivery of factors to hepatocytes by platelets and on the expression of the Asgr1/2...
  37. Treatment for alcoholic liver disease
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..of evidence implicating a requirement for All Trans Retinoic Acid (ATRA) for normal liver function and in liver regeneration. ATRA administration can prevent and reverse the course of liver fibrosis in animal models...
  38. Role of Sensory Neuropeptides in the Regulation of Biliary Function
    Fanyin Meng; Fiscal Year: 2013
    ..by applicant): Human liver is innervated by a dense network of extrinsic and intrinsic nerves that regulate liver regeneration. Cholangiocyte differentiation and biliary remodeling are critical for the maintenance of biliary mass, and ..
  39. Retinoids, Nuclear Receptors, and Hepatocyte Proliferation
    Yu Jui Yvonne Wan; Fiscal Year: 2013
    ..there has been speculation that RA-mediated signaling likely is involved in hepatocyte proliferation during liver regeneration, direct evidence is lacking...
  40. Alcohol-induced changes in hepatic microtubules: mechanisms and consequences
    Pamela L Tuma; Fiscal Year: 2012
    ..However, both of these ligands are also known to promote hepatoprotective activities and are required for liver regeneration. Why are the hepatoprotective and hepatomitogenic effects of TNF-1 and IL-6 selectively lost in alcohol-..
  41. Epigenetic Control of SMC Transitions to a Multi-Potential Stem Cell-Like State
    Gary K Owens; Fiscal Year: 2013
    ..lung epithelial (Clara) cells, myocardial infarction (MI) where they become myofibroblasts (MFs), and liver regeneration where they give rise to Kupfer cells and other hepatic cells yet to be identified...
  42. p53-Regulation in Liver Regeneration
    MICHELLE ANN BARTON; Fiscal Year: 2012
    ..function and regulation in normal hepatic cells and to determine how these functions may be altered during liver regeneration. The proposed research will address how p53 functions in normal, differentiated cells, an area generally ..
  43. Role of FGF10 in liver organogenesis and alcohol-impaired regeneration
    KASPER SAONUN WANG; Fiscal Year: 2010
    ..proposal focuses on the potential role of reduced FGF10 signaling in the setting of ethanol (EtOH) impaired liver regeneration. FgflO, expressed in the embryonic foregut mesoderm, normally interacts with the adjacent endoderm through ..
  44. Role of Wnt/Beta-Catenin Signaling in Liver Development
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..We identified its role in liver regeneration &showed activation of the Wnt/[unreadable]-catenin signaling immediately after partial-hepatectomy (PHx)...
  45. Chemokine regulation of liver injury and recovery
    Alex B Lentsch; Fiscal Year: 2013
    ..Much of our current knowledge regarding liver regeneration has been obtained using animal models of hepatectomy...
  46. Hematopoietic Stem Cell Differentiation and Commitment
    Margaret Goodell; Fiscal Year: 2010
    ..Here, using liver regeneration as a model, we propose to examine the mechanisms of this non-autochthonous cell incorporation in much more ..
  47. Mechanisms of Liver Regeneration After Acetaminophen-Induced Acute Liver Failure
    Udayan Apte; Fiscal Year: 2013
    ..Recent studies in animal models and patients have demonstrated that timely stimulation of innate liver regeneration is associated with better outcomes including transplant free survival in APAP-induced ALF...
  48. HGF and Signaling Pathways in Hepatic Tissue Assembly
    George K Michalopoulos; Fiscal Year: 2013
    ..knock down (KD) of either HGF/Met or EGFR by ShRNA and demonstrated that both have inhibitory effects on liver regeneration, that the one signal cannot compensate totally for the other, and that the effects are different in scope ..
  49. Adult-to-Adult Living Donor Liver Transplantation Study Data Coordinating Center
    Robert M Merion; Fiscal Year: 2013
    ..In addition, we will gain insight into liver regeneration and other biological processes through study of this unique procedure...
  50. Human Pharmacogenetics and Human Liver Regeneration
    GARY A PELTZ; Fiscal Year: 2013
    ..abstract_text> ..
  51. Flavoproteins in Oxidative Protein Folding
    Colin Thorpe; Fiscal Year: 2013
    ..family of flavoproteins, and a representative of the smaller single-domain Erv-like oxidases, augmenter of liver regeneration (ALR)...
  52. Identification of vascular inductive signals in liver regeneration
    Shahin Rafii; Fiscal Year: 2013
    ..of the molecular and cellular pathways that allow expansion and engraftment of hepatocytes and augment liver regeneration will have significant therapeutic impact...
  53. A2ALL Cohort Study: Pyschosocial and Surgical Outcomes
    Abhinav Humar; Fiscal Year: 2013
    ..no intervention on liver regeneration and risk for developing SFSS in recipients identified to have elevated portal pressure post reperfusion of ..
  54. Tumor Necrosis Superfamily Ligands and Lymphocytes Role in Liver Regeneration
    Robert A Anders; Fiscal Year: 2013
    ..Specifically, we are examining the mechanisms by which this potent molecule contributes to liver regeneration. We are focusing upon the interactions between the lymphotoxin receptor on hepatocytes and lymphotoxin ..
  55. Mechanisms of Alcoholic Liver Disease
    Chandrashekhar R Gandhi; Fiscal Year: 2013
    ..Our work using a mouse model of hepatic deficiency of a protein named augmenter of liver regeneration (ALR) indicates that the defects in ALR gene and serum ALR levels could be reliable diagnostic indicators of ..
  56. Stem cell niche and Wnt in liver injury and regeneration.
    BRUCE MAO ZHENG WANG; Fiscal Year: 2013
    ..provided by applicant): Oval cells are adult liver progenitor cells that play a physiologic role in liver regeneration and have attractive therapeutic potential...
  57. Nrf2, Hepatocyte Proliferation, and Liver Regeneration
    Guoli Dai; Fiscal Year: 2013
    ..Remarkably, hepatocyte proliferation constitutes the fundamental process of liver regeneration. Timely and/or enhanced hepatocyte proliferation leads to recovery from liver injury and survival, whereas ..
  58. Regeneration, Repair and Remodeling of the Lower Urinary Tract
    GEORGE JOSEPH CHRIST; Fiscal Year: 2013
    ..contribution and composition of tumor formation, as well as the role of stem cells and gene therapy in liver regeneration and hematopoiesis...
  59. Transcriptional Coactivators in Liver Function
    Janardan K Reddy; Fiscal Year: 2013
    ..of coactivators in liver cells interferes with multiple signaling pathways that regulate energy metabolism, liver regeneration, and liver carcinogenesis...
  60. Gene Expression Pattern of Liver Stem/Progenitor Cells
    Mariana Dabeva; Fiscal Year: 2009
    ..Such factor/s must be different from normal liver regeneration, as OC do not proliferate in the liver when hepatocyte proliferation is not compromised...
  61. The MicroRNA Network and the Deregulation of Liver Regeneration by Ethanol
    Rajanikanth Vadigepalli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Liver regeneration is a clinically important tissue repair mechanism that facilitates the recovery of liver mass after acute damage through proliferation of fully differentiated hepatocytes...
  62. GENE EXPRESSION IN REGENERATING AND NEOPLASTIC LIVERS
    Nelson Fausto; Fiscal Year: 2009
    b>Liver regeneration is a unique biological response in which normally quiescent, differentiated hepatocytes regain proliferate activity...
  63. METABOLIC HOMEOSTASIS IN LIVER REGENERATION
    LINDA GREENBAUM; Fiscal Year: 1999
    b>Liver regeneration following partial hepatectomy is one of the few models in which it is possible to study cellular proliferation in the intact animal...
  64. MOLECULAR CONTROL OF LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    DESCRIPTION: Liver regeneration following partial hepatectomy provides one of the few examples of a physiologic growth response occurring in the intact animal...
  65. Naturally Occurring Agent for Alcohol Liver Diseases
    YUE WEI LEE; Fiscal Year: 2003
    ..adversely affect the hepatocyte proliferative response, as well as those survival mechanisms critical for liver regeneration. The objective of this STTR Phase I and II fast track application is to develop a naturally occurring agent, ..
  66. MOLECULAR REGULATION OF LIVER REGENERATION
    Clifford Steer; Fiscal Year: 1999
    ..novel concept that the methylation status of the genomic DNAs regulate their transcript half-lives during liver regeneration. This will be done using Southern blot and PCR analysis, chimeric gene constructs, and in vitro methylation ..
  67. GENE EXPRESSION IN REGENERATING AND NEOPLASTIC LIVERS
    Nelson Fausto; Fiscal Year: 2000
    During liver regeneration after partial hepatectomy (PH), normally quiescent hepatocytes enter the cell cycle and replicate...
  68. METABLASTIN AND THE CONTROL OF CELL DIVISION
    ULRICH SCHUBART; Fiscal Year: 1999
    ..It is strongly induced in lymphocytes after exposure to mitogens and in hepatocytes during liver regeneration. Metablastin undergoes serine phosphorylation in response to a variety of extracellular factors and during ..
  69. Hepatobiliary Pathophysiology of Liver Regeneration
    DAVID RUDNICK; Fiscal Year: 2009
    ..These observations suggest that this adipogenic program is regulated during and essential for normal liver regeneration. One of the genes identified as induced as part of this response in regenerating liver is adipsin...
  70. The Role of Complement in Liver Regeneration
    John Lambris; Fiscal Year: 2005
    The long-term goal of this research is to define the mechanism(s) by which complement (C') contributes to liver regeneration. The liver has the capacity to regulate its size and growth and to regenerate after partial hepatectomy or toxic ..
  71. Chronic Alcohol Effects on Transcriptional Regulation in Liver Regeneration
    Rajanikanth Vadigepalli; Fiscal Year: 2009
    ..of transcriptional regulatory mechanisms underlying the effects of chronic alcohol exposure on the onset of liver regeneration regeneration...
  72. Increasing Functional Liver Mass in Health and Disease
    Leonidas Koniaris; Fiscal Year: 2005
    Failure of liver regeneration after toxic injury or after resection will result in death. Current treatment options are supportive therapy or liver transplantation...
  73. Liver Regeneration in Man--Effects or Adjuvant Therapy
    Yuman Fong; Fiscal Year: 2005
    ..The current submission examines the cellular alterations underlying liver regeneration and the resultant biological determinants for the optional timing of adjuvant therapy after resection of ..
  74. Spleen regulation of beta-cell regeneration
    Anita Chong; Fiscal Year: 2007
    ..Published results have suggested that the signals triggering liver regeneration also trigger [unreadable]-cell proliferation and regeneration...
  75. FoxM1B Protein in Stimulating Proliferation during Aging
    LESTER LAU; Fiscal Year: 2007
    ..We recently performed liver regeneration studies to demonstrate that maintaining hepatocyte expression of FoxMIB in 12-month old (old-aged) ..
  76. In Vitro Reconstitution of Alpha Fetroprotein Regulation
    Michelle Barton; Fiscal Year: 2007
    ..is re-activated in adult liver in response to renewed cellular proliferation during liver tumorigenesis and liver regeneration. Our proposed studies will test the hypotheses that (Specific Aim I) aberrant loss of regulated AFP ..
  77. REGULATION OF PAI I AND LIVER PATHOLOGY IN THE AGED
    CAROLYN BRUZDZINSKI; Fiscal Year: 1999
    Hepatic compensatory growth (HCG), or liver regeneration, is a critical physiological response to liver injury, disease or liver resection...
  78. ISOLATION AND ACTION OF ADULT HEPATOCYTE MITOGENS
    Hyam Leffert; Fiscal Year: 1991
    The long term objective of this research is to understand how blood-borne substances control liver regeneration. To accomplish this goal, hepatic mitogens will be isolated and purified, characterized structurally, and analyzed for their ..
  79. MOLECULAR REGUL OF HUMAN COLON CANCER LIVER METASTASIS
    Robert Radinsky; Fiscal Year: 1999
    ..also respond to specific mitogenic signals produced by tissue undergoing repair (hepatectomy followed by liver regeneration) demonstrating that physiological signals can be utilized by neoplastic cells...