eating

Summary

Top Publications

  1. ncbi Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
  2. ncbi Effects of the obese gene product on body weight regulation in ob/ob mice
    M A Pelleymounter
    Department of Neurobiology, Amgen, Inc, Thousand Oaks, CA 91320, USA
    Science 269:540-3. 1995
  3. ncbi A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    D E Cummings
    University of Washington, VA Puget Sound Health Care System and Harborview Medical Center, Seattle, Washington 98108, USA
    Diabetes 50:1714-9. 2001
  4. ncbi Stress, eating and the reward system
    Tanja C Adam
    University of California, San Francisco, Department of Psychiatry, United States
    Physiol Behav 91:449-58. 2007
  5. ncbi Entrainment of the circadian clock in the liver by feeding
    K A Stokkan
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
    Science 291:490-3. 2001
  6. ncbi Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
    L A Campfield
    Department of Metabolic Diseases, Hoffmann La Roche Incorporated, Nutley, NJ 07110, USA
    Science 269:546-9. 1995
  7. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
  8. pmc Diet-induced obese mice develop peripheral, but not central, resistance to leptin
    M van Heek
    Department of CNS and Cardiovascular Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Clin Invest 99:385-90. 1997
  9. ncbi Divergence of melanocortin pathways in the control of food intake and energy expenditure
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell 123:493-505. 2005
  10. ncbi Trophic action of leptin on hypothalamic neurons that regulate feeding
    Sebastien G Bouret
    Division of Neuroscience, Oregon National Primate Research Center and Oregon Health and Science University, Beaverton, OR 97006, USA
    Science 304:108-10. 2004

Detail Information

Publications371 found, 100 shown here

  1. ncbi Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
    ..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores...
  2. ncbi Effects of the obese gene product on body weight regulation in ob/ob mice
    M A Pelleymounter
    Department of Neurobiology, Amgen, Inc, Thousand Oaks, CA 91320, USA
    Science 269:540-3. 1995
    ..These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite...
  3. ncbi A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    D E Cummings
    University of Washington, VA Puget Sound Health Care System and Harborview Medical Center, Seattle, Washington 98108, USA
    Diabetes 50:1714-9. 2001
    ..ghrelin levels increased nearly twofold immediately before each meal and fell to trough levels within 1 h after eating, a pattern reciprocal to that of insulin...
  4. ncbi Stress, eating and the reward system
    Tanja C Adam
    University of California, San Francisco, Department of Psychiatry, United States
    Physiol Behav 91:449-58. 2007
    ..we attempt to link animal and human literatures to tease apart how different types of psychological stress affect eating. We propose a theoretical model of Reward Based Stress Eating...
  5. ncbi Entrainment of the circadian clock in the liver by feeding
    K A Stokkan
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
    Science 291:490-3. 2001
    ..They also raise the possibility that peripheral circadian oscillators like those in the liver may be coupled to the SCN primarily through rhythmic behavior, such as feeding...
  6. ncbi Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
    L A Campfield
    Department of Metabolic Diseases, Hoffmann La Roche Incorporated, Nutley, NJ 07110, USA
    Science 269:546-9. 1995
    ..The behavioral effects after brain administration suggest that OB protein can act directly on neuronal networks that control feeding and energy balance...
  7. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake...
  8. pmc Diet-induced obese mice develop peripheral, but not central, resistance to leptin
    M van Heek
    Department of CNS and Cardiovascular Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Clin Invest 99:385-90. 1997
    ..These data demonstrate that, in a diet-induced obesity model, mice exhibit resistance to peripherally administered leptin, while retaining sensitivity to centrally administered leptin...
  9. ncbi Divergence of melanocortin pathways in the control of food intake and energy expenditure
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell 123:493-505. 2005
    ..Disassociation of food intake and energy expenditure reveals unexpected divergence in melanocortin pathways controlling energy balance...
  10. ncbi Trophic action of leptin on hypothalamic neurons that regulate feeding
    Sebastien G Bouret
    Division of Neuroscience, Oregon National Primate Research Center and Oregon Health and Science University, Beaverton, OR 97006, USA
    Science 304:108-10. 2004
    ..These results suggest that leptin plays a neurotrophic role during the development of the hypothalamus and that this activity is restricted to a neonatal critical period that precedes leptin's acute regulation of food intake in adults...
  11. pmc Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    Qingchun Tong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave, Boston, Massachusetts 02215, USA
    Nat Neurosci 11:998-1000. 2008
    ..These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance...
  12. pmc The contribution of expanding portion sizes to the US obesity epidemic
    Lisa R Young
    Department of Nutrition and Food Studies, New York University, New York City, 10012 1172, USA
    Am J Public Health 92:246-9. 2002
    ....
  13. ncbi Confirmatory factor analysis of the Child Feeding Questionnaire: a measure of parental attitudes, beliefs and practices about child feeding and obesity proneness
    L L Birch
    Department of Human Development and Family Studies and Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
    Appetite 36:201-10. 2001
    ..The CFQ is designed for use with parents of children ranging in age from about 2 to 11 years of age...
  14. ncbi Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA
    Neuron 42:983-91. 2004
    ..In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis...
  15. pmc Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
    Michael J Krashes
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 121:1424-8. 2011
    ..Due to its ease of use and suitability for both acute and chronic regulation, DREADD technology is ideally suited for investigating the neural circuits hypothesized to regulate energy balance...
  16. ncbi Ghrelin enhances appetite and increases food intake in humans
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 86:5992. 2001
    ..Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man. Endogenous ghrelin is a potentially important new regulator of the complex systems controlling food intake and body weight...
  17. pmc The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    Thomas Gerken
    Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
    Science 318:1469-72. 2007
    ..Studies can now be directed toward determining the physiologically relevant FTO substrate and how nucleic acid methylation status is linked to increased fat mass...
  18. ncbi Development of the Healthy Eating Index-2005
    Patricia M Guenther
    Center for Nutrition Policy and Promotion, US Department of Agriculture, 3101 Park Center Drive, Suite 1034, Alexandria, VA 22302, USA
    J Am Diet Assoc 108:1896-901. 2008
    The Healthy Eating Index (HEI) is a measure of diet quality as specified by Federal dietary guidance, and publication of the Dietary Guidelines for Americans 2005 necessitated its revision...
  19. pmc Influence of peers and friends on children's and adolescents' eating and activity behaviors
    Sarah Jeanne Salvy
    RAND Corporation, Santa Monica, CA 90407 2138, USA
    Physiol Behav 106:369-78. 2012
    ..have been theoretically and empirically related to the "Big Two" contributors to the obesity epidemic, unhealthy eating and physical inactivity...
  20. ncbi Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    Heike Munzberg
    Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 145:4880-9. 2004
    ..Defects in leptin action in the ARC may play a role in the pathogenesis of leptin-resistant obesity...
  21. pmc Circadian timing of food intake contributes to weight gain
    Deanna M Arble
    Center for Sleep and Circadian Biology, Northwestern University, Evanston, Illinois, USA
    Obesity (Silver Spring) 17:2100-2. 2009
    ..A better understanding of the role of the circadian system for weight gain could have important implications for developing new therapeutic strategies for combating the obesity epidemic facing the human population today...
  22. ncbi Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    D Huszar
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Cell 88:131-41. 1997
    ..Our data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R...
  23. ncbi Rapid rewiring of arcuate nucleus feeding circuits by leptin
    Shirly Pinto
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 304:110-5. 2004
    ..These data suggest that leptin-mediated plasticity in the ob/ob hypothalamus may underlie some of the hormone's behavioral effects...
  24. pmc Heat or insulation: behavioral titration of mouse preference for warmth or access to a nest
    Brianna N Gaskill
    Department of Animal Science, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 7:e32799. 2012
    ..Our results suggest that under normal laboratory temperatures, mice should be provided with no less than 6 grams of nesting material, but up to 10 grams may be needed to alleviate thermal distress under typical temperatures...
  25. pmc Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake
    Amanda M Dossat
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4301, USA
    J Neurosci 31:14453-7. 2011
    ..We conclude that that GLP-1Rs in the NAc play a physiologic role in food intake control, and suggest that the GLP-1 projection to NAc core may link satiation signal processing in the hindbrain with forebrain processing of food reward...
  26. pmc Eating patterns and type 2 diabetes risk in men: breakfast omission, eating frequency, and snacking
    Rania A Mekary
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 95:1182-9. 2012
    Little is known about the association between eating patterns and type 2 diabetes (T2D) risk.
  27. ncbi Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003
    ..However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigated whether obese subjects were also resistant to the anorectic effects of PYY...
  28. ncbi Psychometric properties and factor structure of the Three-Factor Eating Questionnaire (TFEQ) in obese men and women. Results from the Swedish Obese Subjects (SOS) study
    J Karlsson
    Health Care Research Unit, Sahlgrenska University Hospital, University of Goteborg, Sweden
    Int J Obes Relat Metab Disord 24:1715-25. 2000
    To evaluate the construct validity of the Three-Factor Eating Questionnaire (TFEQ) in obese men and women.
  29. ncbi Breakfast skipping and health-compromising behaviors in adolescents and adults
    A Keski-Rahkonen
    Department of Public Health, PO Box 41, University of Helsinki, Helsinki 00014, Finland
    Eur J Clin Nutr 57:842-53. 2003
    ..To investigate which sociodemographic factors and behaviors are associated with breakfast skipping in adolescents and adults...
  30. ncbi Phenotypic and genetic parameters for different measures of feed efficiency in different breeds of Irish performance-tested beef bulls
    J J Crowley
    Teagasc, Moorepark Dairy Production Research Centre, Fermoy, Co Cork, Ireland
    J Anim Sci 88:885-94. 2010
    ..Results from this study indicate significant genetic differences in performance and some measures of feed efficiency among performance-tested beef bulls...
  31. ncbi Fine mapping quantitative trait loci for feed intake and feed efficiency in beef cattle
    E L Sherman
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
    J Anim Sci 87:37-45. 2009
    ..The identification of these QTL provides a starting point to identify genes affecting feed intake and efficiency for use in marker-assisted selection and management...
  32. pmc Appetite control: methodological aspects of the evaluation of foods
    J Blundell
    Institute of Psychological Sciences, University of Leeds, Leeds
    Obes Rev 11:251-70. 2010
    ..One main objective of the report has been to produce guidance on good practice in carrying out appetite research, and not to set down a series of commandments that must be followed...
  33. pmc The lipid messenger OEA links dietary fat intake to satiety
    Gary J Schwartz
    Diabetes Research Center, Departments of Medicine and Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    Cell Metab 8:281-8. 2008
    ..The results suggest that activation of small-intestinal OEA mobilization, enabled by CD36-mediated uptake of dietary oleic acid, serves as a molecular sensor linking fat ingestion to satiety...
  34. ncbi Relationship between stress, eating behavior, and obesity
    Susan J Torres
    Centre for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
    Nutrition 23:887-94. 2007
    Stress is thought to influence human eating behavior and has been examined in animal and human studies...
  35. pmc The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin
    Douglas A Velásquez
    Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    Diabetes 60:1177-85. 2011
    ..We tested the hypothesis that the central SIRT1/p53 pathway might be mediating the orexigenic action of ghrelin...
  36. pmc The hormonal control of food intake
    Anthony P Coll
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, United Kingdom
    Cell 129:251-62. 2007
    ..These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas. In this Review we provide a synthesis of recent evidence concerning the actions of these hormones on food intake...
  37. pmc Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
    Jari Rossi
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 13:195-204. 2011
    ..Our results also provide further evidence of the dissociation in pathways mediating the effects of melanocortins on energy balance and glucose homeostasis...
  38. ncbi A role for glucagon-like peptide-1 in the central regulation of feeding
    M D Turton
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nature 379:69-72. 1996
    ..Both of these regions of the brain are of primary importance in the regulation of feeding. These findings suggest that central GLP-1 is a new physiological mediator of satiety...
  39. pmc Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1898-908. 2012
    ..The relationships between oxytocin, food-motivation neurocircuitry, and disordered eating psychopathology have not been investigated in humans.
  40. ncbi A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
    Raquel Gomez
    University Institute of Drug Dependencies, Department of Psychobiology, University Complutense of Madrid, Madrid 28223, Spain
    J Neurosci 22:9612-7. 2002
    ..Pretreatment with SR141716A enhanced the inhibition of feeding induced by intraperitoneal administration of oleoylethanolamide. The results reveal an unexpected role for peripheral CB1 receptors in the regulation of feeding...
  41. ncbi Association between eating patterns and obesity in a free-living US adult population
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Epidemiol 158:85-92. 2003
    Some studies have suggested that eating patterns, which describe eating frequency, the temporal distribution of eating events across the day, breakfast skipping, and the frequency of eating meals away from home, may be related to obesity...
  42. pmc Metabolic and hedonic drives in the neural control of appetite: who is the boss?
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Curr Opin Neurobiol 21:888-96. 2011
    ..in the identification of neural circuits that represent the interface between the metabolic and hedonic drives of eating. We will cover these new findings by focusing first on the capacity of metabolic signals to modulate processing of ..
  43. pmc Energy density, portion size, and eating occasions: contributions to increased energy intake in the United States, 1977-2006
    Kiyah J Duffey
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA
    PLoS Med 8:e1001050. 2011
    ..Our objective was to examine the relative contribution of energy density (ED), portion size (PS), and the number of eating/drinking occasions (EOs) to changes in daily TE.
  44. ncbi Associations of marker panel scores with feed intake and efficiency traits in beef cattle using preselected single nucleotide polymorphisms
    F D N Mujibi
    Department of Agriculture, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada
    J Anim Sci 89:3362-71. 2011
    ....
  45. ncbi Inactivation of the Fto gene protects from obesity
    Julia Fischer
    Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitatsstr 1, D 40225 Dusseldorf, Germany
    Nature 458:894-8. 2009
    ..Taken together, these experiments provide, to our knowledge, the first direct demonstration that Fto is functionally involved in energy homeostasis by the control of energy expenditure...
  46. ncbi Central administration of oleic acid inhibits glucose production and food intake
    Silvana Obici
    Departments of Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 51:271-5. 2002
    ..This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation...
  47. pmc Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure
    Linda Rinaman
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Brain Res 1350:18-34. 2010
    ..e., hypophagic) responses to stress...
  48. pmc Enhanced striatal dopamine release during food stimulation in binge eating disorder
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Obesity (Silver Spring) 19:1601-8. 2011
    Subjects with binge eating disorder (BED) regularly consume large amounts of food in short time periods. The neurobiology of BED is poorly understood. Brain dopamine, which regulates motivation for food intake, is likely to be involved...
  49. pmc De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance
    Andrew A Pierce
    Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:723-30. 2010
    ..It further suggests that de novo neurogenesis might serve as a compensatory mechanism contributing to the plastic control of energy balance in response to environmental and physiologic insults...
  50. pmc Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
    E Stice
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    Science 322:449-52. 2008
    ....
  51. pmc Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    Baoji Xu
    Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    Nat Neurosci 6:736-42. 2003
    ..These results show that MC4R signaling controls BDNF expression in the VMH and support the hypothesis that BDNF is an important effector through which MC4R signaling controls energy balance...
  52. ncbi The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors
    Suzanne L Dickson
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, SE 405 30 Gothenburg, Sweden
    J Neurosci 32:4812-20. 2012
    ....
  53. pmc Television-viewing characteristics of adults: correlations to eating practices and overweight and health status
    Shanthy A Bowman
    Agricultural Research Service, Community Nutrition Research Group, Beltsville Human Nutrition Research Center, United States Department of Agriculture, BARC West, Beltsville, MD 20705 2350, USA
    Prev Chronic Dis 3:A38. 2006
    The purpose of this study was to examine the associations among television viewing, eating practices, and overweight and health status of a nationally representative sample of adults in the United States.
  54. ncbi A review of family and social determinants of children's eating patterns and diet quality
    Heather Patrick
    Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Coll Nutr 24:83-92. 2005
    ..problem of childhood obesity, recent research has begun to focus on family and social influences on children's eating patterns...
  55. ncbi Partial-genome evaluation of postweaning feed intake and efficiency of crossbred beef cattle
    W M Snelling
    USDA, ARS, US Meat Animal Research Center, PO Box 166, Clay Center, NE 68933, USA
    J Anim Sci 89:1731-41. 2011
    ....
  56. pmc Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms
    Elisabeth B Rüttimann
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, 8603 Schwerzenbach, Switzerland
    Endocrinology 150:1174-81. 2009
    ..The findings suggest that iv GLP-1 infusions do not inhibit eating via hepatic portal or hepatic GLP-1 receptors but may act directly on the brain.
  57. ncbi Leptin receptor signaling in midbrain dopamine neurons regulates feeding
    Jonathan D Hommel
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Neuron 51:801-10. 2006
    ..These data support a critical role for VTA Lepr in regulating feeding behavior and provide functional evidence for direct action of a peripheral metabolic signal on VTA dopamine neurons...
  58. ncbi Ghrelin modulates brain activity in areas that control appetitive behavior
    Saima Malik
    Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
    Cell Metab 7:400-9. 2008
    ..This demonstrates that metabolic signals such as ghrelin may favor food consumption by enhancing the hedonic and incentive responses to food-related cues...
  59. pmc Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
    Kelly A Posey
    Vanderbilt Medical Center, Nashville TN 37232, USA
    Am J Physiol Endocrinol Metab 296:E1003-12. 2009
    ....
  60. ncbi Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
    James E Blevins
    VA Puget Sound Health Care System, Research Service 151 1660 S Columbian Wy, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 287:R87-96. 2004
    ....
  61. pmc Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats
    Stanislav Shklyaev
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610 0266, USA
    Proc Natl Acad Sci U S A 100:14217-22. 2003
    ..These data show successful peripheral therapy in a clinically relevant model for human obesity and insulin resistance...
  62. ncbi Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat
    Myrtha Arnold
    Institute of Animal Sciences, Swiss Federal Institute of Technology Zurich, Schwerzenbach 8603, Switzerland
    J Neurosci 26:11052-60. 2006
    ..is unique among gut peptides in that its plasma level increases during fasts and its administration stimulates eating. Although ghrelin physiology has been intensively studied, whether its eating-stimulatory effect arises from ..
  63. ncbi The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
    Bruce M King
    Department of Psychology, University of New Orleans, New Orleans, LA 70148, USA
    Physiol Behav 87:221-44. 2006
    ....
  64. ncbi Human distribution and release of a putative new gut hormone, peptide YY
    T E Adrian
    Gastroenterology 89:1070-7. 1985
    ..The known potent biologic actions of PYY, its high concentrations in gut endocrine cells, and its release into the circulation after a normal meal suggest that this peptide may function physiologically as a circulating gut hormone...
  65. ncbi Interleukin-6-deficient mice develop mature-onset obesity
    Ville Wallenius
    Research Center for Endocrinology and Metabolism, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    Nat Med 8:75-9. 2002
    ..Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents...
  66. pmc Insulin, leptin, and food reward: update 2008
    Dianne P Figlewicz
    Metabolism Endocrinology 151 VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 296:R9-R19. 2009
    ..The understanding of neuroendocrine modulation of food reward, as well as food reward modulation by diet and obesity, may point to new directions for therapeutic approaches to overeating or eating disorders.
  67. ncbi Ghrelin causes hyperphagia and obesity in rats
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Diabetes 50:2540-7. 2001
    ..saline 2.2 +/- 3.8 g, P < 0.05) and adiposity. These data provide evidence that ghrelin is important in long-term control of food intake and body weight and that circulating ghrelin at fasting concentrations may stimulate food intake...
  68. ncbi Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake
    Naoto Kubota
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cell Metab 6:55-68. 2007
    ..We conclude that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system...
  69. ncbi Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior
    E Epel
    UCSF Health Psychology Program, 3333 California St, Suite 465, San Francisco, CA 94118, USA
    Psychoneuroendocrinology 26:37-49. 2001
    To date, there are few known predictors of stress-induced eating. The purpose of this study was to identify whether physiological and psychological variables are related to eating after stress...
  70. ncbi School food environments and practices affect dietary behaviors of US public school children
    Ronette R Briefel
    Mathematica Policy Research, Inc, PO Box 2393, Princeton, NJ 08543 2393, USA
    J Am Diet Assoc 109:S91-107. 2009
    ..Changes to school food environments and practices that lead to improved dietary behavior are a powerful strategy to reverse the childhood obesity epidemic...
  71. ncbi Whole genome single nucleotide polymorphism associations with feed intake and feed efficiency in beef cattle
    E L Sherman
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
    J Anim Sci 88:16-22. 2010
    ....
  72. ncbi Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects
    Rosa Morínigo
    Obesity Unit, Hospital Clinic Universitari, Villarroel 170, 08036 Barcelona, Spain
    J Clin Endocrinol Metab 91:1735-40. 2006
    ..The mechanisms underlying weight loss after Roux-en-Y gastric bypass (RYGBP) are not well understood...
  73. ncbi Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
    J Kamegai
    Department of Medicine, Nippon Medical School, Tokyo, Japan
    Diabetes 50:2438-43. 2001
    ..0 +/- 22.5% of saline-treated controls; P < 0.05) in the arcuate nucleus. Thus, the primary hypothalamic targets of ghrelin are NPY/AGRP-containing neurons, and ghrelin is a newly discovered orexigenic peptide in the brain and stomach...
  74. ncbi Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work
    Roberto Salgado-Delgado
    Departamento de Anatomia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF 04510, Mexico
    Endocrinology 151:1019-29. 2010
    ..These observations demonstrate that feeding habits may prevent or induce internal desynchrony and obesity...
  75. ncbi Modifying the Healthy Eating Index to assess diet quality in children and adolescents
    Diane Feskanich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    J Am Diet Assoc 104:1375-83. 2004
    The Healthy Eating Index (HEI) is a scoring system used by the US government to assess adherence to the Dietary Guidelines for Americans. We examined the ability of the HEI to monitor diet quality among youth.
  76. ncbi Agouti-related peptide-expressing neurons are mandatory for feeding
    Eva Gropp
    Institute for Genetics and Center for Molecular Medicine CMMC, Department of Mouse Genetics and Metabolism, University of Cologne, Zülpicher Str 47, 50674 Koln, Germany
    Nat Neurosci 8:1289-91. 2005
    ....
  77. pmc Ghrelin action in the brain controls adipocyte metabolism
    Claudia Theander-Carrillo
    Laboratory of Metabolism, Division of Endocrinology, Diabetology, and Nutrition, Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Clin Invest 116:1983-93. 2006
    ..These results unravel the existence of what we believe to be a new CNS-based neuroendocrine circuit regulating metabolic homeostasis of adipose tissue...
  78. pmc Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats
    Adam P Chambers
    Obesity Research Center and the Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Gastroenterology 141:950-8. 2011
    ..We investigated alterations in glucose metabolism in rats following RYGB or VSG...
  79. ncbi Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating
    Wolfgang Langhans
    Physiology and Behaviour Laboratory, Institute of Food Nutrition and Health, Zurich, Schwerzenbach, Switzerland
    Am J Physiol Regul Integr Comp Physiol 300:R554-65. 2011
    ..TAG-derived energy by translating enterocyte fatty acid oxidation (FAO) into vagal afferent signals controlling eating. Peripheral FAO has long been implicated in the control of eating (141)...
  80. ncbi Food neophobia and 'picky/fussy' eating in children: a review
    Terence M Dovey
    Department of Psychology, Staffordshire University, College Road, Stoke on Trent, Staffordshire ST4 2DE, UK
    Appetite 50:181-93. 2008
    ..been shown to contribute to rejection or acceptance of fruits and vegetables: food neophobia and 'picky/fussy' eating. Food neophobia is generally regarded as the reluctance to eat, or the avoidance of, new foods...
  81. ncbi Normative influences on food intake
    C Peter Herman
    Department of Psychology, University of Toronto, Toronto, ON, Canada M5S 3G3
    Physiol Behav 86:762-72. 2005
    Hunger and satiety have conventionally provided the framework for understanding eating and overeating. We argue that hunger and satiety play a relatively small role in everyday eating...
  82. pmc Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase
    Pablo B Martínez de Morentin
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Diabetes 61:807-17. 2012
    ..Overall these data demonstrate that the effects of nicotine on energy balance involve specific modulation of the hypothalamic AMPK-BAT axis. These targets may be relevant for the development of new therapies for human obesity...
  83. ncbi Residual intake and body weight gain: a new measure of efficiency in growing cattle
    D P Berry
    Animal and Grassland Research and Innovation Centre, Teagasc, Moorepark, Fermoy, Co Cork, Ireland
    J Anim Sci 90:109-15. 2012
    ..The advantages of both reduced daily DMI and greater ADG in animals superior for RIG are demonstrated compared with animals superior for either RFI or RG...
  84. pmc The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide
    Scott E Kanoski
    Department of Psychology, School of Art and Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 62:1916-27. 2012
    ....
  85. pmc GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake
    Amber L Alhadeff
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 153:647-58. 2012
    ..Current data highlight these nuclei within the MRS as novel sites for GLP-1R-mediated control of food intake and body weight...
  86. ncbi The importance of exposure for healthy eating in childhood: a review
    L Cooke
    Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, Gower Street, London, UK
    J Hum Nutr Diet 20:294-301. 2007
    ..If future large-scale interventions prove to be successful, training could be offered to health professionals or directly to parents themselves...
  87. pmc Effects of food form and timing of ingestion on appetite and energy intake in lean young adults and in young adults with obesity
    Richard D Mattes
    Department of Foods and Nutrition, Purdue University, 212 Stone Hall, 700 W State St, West Lafayette, IN 47907 2059, USA
    J Am Diet Assoc 109:430-7. 2009
    Overweight and obesity have been attributed to increased eating frequency and the size of eating events. This study explored the influence of the timing of eating events and food form on appetite and daily energy intake.
  88. pmc An obligate role of oxytocin neurons in diet induced energy expenditure
    Zhaofei Wu
    Brown Foundation Institute of Molecular Medicine, University of Texas Medical School at Houston, Houston, Texas, USA
    PLoS ONE 7:e45167. 2012
    ..Thus, our study suggests that oxytocin neurons are required to resist the obesity associated with a high fat diet; but their role in feeding is permissive and can be compensated for by redundant pathways...
  89. pmc Psychological determinants of emotional eating in adolescence
    Selena T Nguyen-Rodriguez
    Institute for Health Promotion and Disease Prevention, Keck School of Medicine, University of Southern California, 1000 S Freemont Ave, Unit 8, BldgA4, Rm 4102, Alhambra, CA 91803, USA
    Eat Disord 17:211-24. 2009
    Emotional eating is conceptualized as eating in response to negative affect. Data from a larger study of physical activity was employed to examine the associations among specific emotions/moods and emotional eating in an adolescent sample...
  90. pmc Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice
    Sun Ju Choi
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Diabetes and Obesity Center of Excellence, Seattle, WA 98109, USA
    Am J Physiol Endocrinol Metab 300:E1031-7. 2011
    ..2 g vs. WT: -1.6 ± 0.1, P < 0.05) were increased in myostatin-deficient mice compared with WT controls. We conclude that increased EE, together with increased leptin sensitivity, contributes to low fat mass in mice lacking myostatin...
  91. ncbi Serotonin reciprocally regulates melanocortin neurons to modulate food intake
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom
    Neuron 51:239-49. 2006
    ....
  92. ncbi The histamine H3 receptor and eating behavior
    Maria Beatrice Passani
    Dip Farmacologia preclinica e clinica, V le G Pieraccini 6, 50139 Firenze, Italy
    J Pharmacol Exp Ther 336:24-9. 2011
    ..b>Eating behavior is regulated by a complex interplay of central neurotransmitter systems, peripheral endocrine stimuli, ..
  93. pmc Role of the glucagon-like-peptide-1 receptor in the control of energy balance
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Physiol Behav 100:503-10. 2010
    ..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009...
  94. ncbi Signals that regulate food intake and energy homeostasis
    S C Woods
    Department of Psychiatry, University of Cincinnati Medical Center, Post Office Box 670559, Cincinnati, OH 45267 0559, USA
    Science 280:1378-83. 1998
    ..This review focuses on the molecular signals that modulate food intake while integrating the body's immediate and long-term energy needs...
  95. ncbi Situational effects on meal intake: A comparison of eating alone and eating with others
    Marion M Hetherington
    Department of Psychology, Glasgow Caledonian University, Glasgow, Scotland, UK
    Physiol Behav 88:498-505. 2006
    b>Eating in competition with other tasks has been shown to increase food intake, particularly when tasks are cognitively demanding...
  96. ncbi A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans
    C Verdich
    Research Department of Human Nutrition, Centre for Food, The Royal Veterinary and Agricultural University, DK-1958 Frederiksberg C, Denmark
    J Clin Endocrinol Metab 86:4382-9. 2001
    ..Glucagon-like peptide-1 infusion reduces energy intake dose dependently in both lean and overweight subjects. A reduced gastric emptying rate may contribute to the increased satiety induced by glucagon-like peptide-1...
  97. ncbi Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit
    A Sainsbury
    Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia
    Mol Cell Endocrinol 316:109-19. 2010
    ....
  98. pmc Leptin regulates striatal regions and human eating behavior
    I Sadaf Farooqi
    University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Science 317:1355. 2007
    ....
  99. ncbi The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy
    Mark H Vickers
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Endocrinology 149:1906-13. 2008
    ..These data further reinforce the importance of leptin in determining long-term energy homeostasis, and suggest that leptin's effects are modulated by gender and both prenatal and postnatal nutritional status...
  100. pmc Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling
    Christa M Patterson
    Neurology Service 127C VA Medical Center, 385 Tremont Ave, E Orange, NJ 07018 1095, USA
    Am J Physiol Regul Integr Comp Physiol 296:R537-48. 2009
    ..These data suggest that brief postweaning exercise in DIO rats that are inherently leptin resistant causes a sustained resistance to obesity on HE diet, which is, in part, due to increased central leptin sensitivity...
  101. ncbi The regulation of seasonal changes in food intake and body weight
    F J P Ebling
    School of Biomedical Sciences and Institute of Neuroscience, University of Nottingham Medical School, Nottingham, UK
    J Neuroendocrinol 20:827-33. 2008
    ....

Research Grants80

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..The pill should be taken in the morning (at least 4 hours after eating and at least 30 minutes before eating)...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..The pill should be taken in the morning (at least 4 hours after eating and at least 30 minutes before eating)...
  3. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..She is experienced in measuring children's eating behaviour and has published on genetic influences, including effects of the FTO gene...
  4. Neurobehavioral Correlates of Familial/genetic obesity risk in adolescents
    Susan Carnell; Fiscal Year: 2013
    ..She is experienced in measuring children's eating behaviour and has published on genetic influences, including effects of the FTO gene...
  5. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..A considerable body of literature has developed that suggests that eating the majority of calories as fat results in the development of insulin resistance and type II diabetes mellitus...
  6. Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome Risk
    PEI AN SHIH; Fiscal Year: 2013
    ..Plasma NPY and PYY levels associate with eating and metabolic disorders, yet precise mechanisms underlying associations are difficult to identify due to the ..
  7. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
    ..effects on energy homeostasis and changes in these rhythms can result in metabolic syndrome or in disordered eating patterns associated with obesity like binge eating or night eating...
  8. Diet Quality and CVD Risk Factors in a Family Based Weight Management Study
    Alice H Lichtenstein; Fiscal Year: 2013
    ..The Control Intervention group will receive a booklet with targets for healthy eating behaviors, a handout on how to increase physical activity, and quarterly visits that will include a brief review ..
  9. Leptin function &resistance in midbrain VTA &SN in reward eating &obesity
    YI NONE ZHANG; Fiscal Year: 2013
    ..to validate the newly proposed leptin physiological function in the SN on energy homeostasis and/or reward eating. Potential effects of leptin in the SN will be compared to those in the VTA...
  10. Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2013
    ..food search and consumption, such as exploration, anxiety, aggressiveness, bulimic like behaviors versus slow eating, and the hedonistic influence of food...
  11. Regulation of Metabolism by Dietary Sterols
    SHAILENDRA BHANUBHAI PATEL; Fiscal Year: 2013
    ..that can amplify effects of plant sterols in the diet, which may shed light on potential issues with humans eating functional foods...
  12. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..Because melanopsin is involved in a variety of physiological functions including sleep, mental alertness, eating habits, and hormonal levels, as well potentially involved in a variety of disorders including sleep disorders, ..
  13. The Role of Estradiol and Sex in the Effects of Ghrelin on Meal Patterns and Fos-
    PETER BUTERA; Fiscal Year: 2009
    ..The actions of estradiol on neural systems that regulate eating may also account in part for sex differences in food intake and eating disorders, which occur much more frequently ..
  14. Appetite-regulating Hormones and Neurocircuitry in Anorexia Nervosa
    ELIZABETH AUSTEN LAWSON; Fiscal Year: 2013
    ..a novel, multidisciplinary approach to understanding endocrine factors and neurocircuitry underlying appetite and eating behavior in anorexia nervosa (AN)...
  15. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..for AN and BN have been elusive, and there is little understanding of puzzling symptoms such as extremes of eating behaviors...
  16. Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk
    Sheila Gahagan; Fiscal Year: 2012
    ..At 16 to 17 years, the youth will participate in study of activity, sleep and eating patterns using actigraphic recording and laboratory assessment of eating behavior...
  17. Novel High Affinity and Long-Acting Bovine FSH Analogs for Veterinary Superovulat
    BRUCE DALE WEINTRAUB; Fiscal Year: 2012
    ..possible contamination by a protein infectious agent which causes a 100% fatal brain disease in humans after eating such infected meat...
  18. The role of acyl-CoA binding proteins in selective autophagy
    Taras Y Nazarko; Fiscal Year: 2013
    ..to correct lipid metabolism in humans by modulating lipophagy, the selective autophagy (or the cell's "self-eating") of LDs...
  19. Transforming Women's Health: Discovery, Development, and Delivery
    Ellen M Daley; Fiscal Year: 2012
    ..affect women include various infectious (HIV/AIDS), chronic (cardiovascular disease), behavioral (eating disorders), psychosocial (stress) and socio-economic health conditions (poverty)...
  20. A Mindfulness-Based Approach to the Treatment of Obesity and Diabetes
    Carla K Miller; Fiscal Year: 2010
    ..interactions such that hyperglycemia may adversely affect mood, and depressed mood may contribute to poor eating habits, physical inactivity, and further weight gain...
  21. Neonatal Programming of Growth and Maturation in Rhesus Monkeys
    Andrew Muir; Fiscal Year: 2013
    ..We will evaluate eating, physical activity, growth, maturation, insulin sensitivity, and inflammation in infants programmed by maternal ..
  22. DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASE
    Frank B Hu; Fiscal Year: 2013
    ..we will evaluate the long-term relationship between changes in diet quality indices (such as the alternate Healthy Eating Index [aHEI], alternate Mediterranean Diet [aMED], Dietary Approaches to Stop Hypertension [DASH], Food Quality ..
  23. Mother Sibling Interactions
    Julie A Thompson; Fiscal Year: 2010
    ..1] The day-to-day routines and structure are altered, including peer-play activities, family activities, and eating and bedtime routines...
  24. A twin study of ovarian hormones and disordered eating
    Kelly L Klump; Fiscal Year: 2012
    ..are to examine: 1) phenotypic relationships between changes in ovarian hormone levels and changes in disordered eating across the menstrual cycle in a large sample of female twins;and 2) whether a common set of genetic factors ..
  25. Evaluating Economic Subsidies To Improve Dietary Intake Among Low Income Families
    Marian L Fitzgibbon; Fiscal Year: 2010
    ..a rare opportunity to evaluate the impact of a national policy shift in food assistance to support healthy eating in low- income families...
  26. Creation of Eating/Activity Environments by New Mothers
    Deborah Young Hyman; Fiscal Year: 2010
    ..New first time mothers create the eating and physical activity (PA) environment for themselves and their baby, thereby increasing the risk for or ..
  27. Social Networks &Breast Cancer Prognosis in the Chinese and US Evaluation Study
    Candyce H Kroenke; Fiscal Year: 2013
    ..CAUSE) Cohort which includes women from the Life After Cancer Epidemiology (LACE), the Women's Healthy Eating and Living (WHEL) and the Shanghai Breast Cancer Cohort (SBCC) studies...
  28. Diet, Insulin, Dopamine, and Reward.
    Margaret E Rice; Fiscal Year: 2013
    ..The increasing prevalence of insulin resistance and obesity and the high comorbidity of disordered eating and substance abuse indicate that understanding the connections among diet, insulin, DA and reward will have ..
  29. Improving Outcomes for Women with GDM and Their Infants
    Alison M Stuebe; Fiscal Year: 2013
    ..Promoting Lifestyle Profile II, Adult Health Behavior Survey, and Accelerometry for 7 days);and self-efficacy (Eating Self-Efficacy, Exercise Self-Efficacy Scale, and Breastfeeding Self-Efficacy Scale)...
  30. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    DIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2013
    ..Our experiments thus model one aspect of the eating habits of people in 'Westernized'societies such as the U.S...
  31. GAS Switch from Colonizing Bacterium to Invasive Pathogen
    Victor Nizet; Fiscal Year: 2012
    ..in humans of all ages, from simple [unreadable]strep throat[unreadable] to life-threatening [unreadable]flesh-eating[unreadable] infections and shock...
  32. Endocannabinoid Discrimination
    Jenny L Wiley; Fiscal Year: 2013
    ..in the pathophysiology of a variety of health problems related to these processes, including substance abuse, eating disorders, other types of addictive behavior, and psychiatric disorders...
  33. INTERACTIONS OF LEPTIN AND CENTRAL SEROTONIN SYSTEMS
    Joel K Elmquist; Fiscal Year: 2013
    ..This may lead to effective strategies to combat the incidence of obesity, diabetes and eating disorders...
  34. The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty
    Kelly L Klump; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eating disorders are significant mental health problems that affect over 5 million women in the United States...
  35. Novel interventions to reduce stress induced non-homeostatic eating
    Barbara A Laraia; Fiscal Year: 2012
    ..to test novel interventions based on the physiology by which stress and reward from palatable food influence eating behaviors and abdominal fat deposition...
  36. Dietary Patterns, Diet Quality + Cancer Risk
    Frank B Hu; Fiscal Year: 2012
    ..We will examine both pre- and post-diagnostic dietary patterns (including low-carbohydrate scores and the Healthy Eating Index) in relation to survival rates of patients with breast, colon, or prostate cancer...
  37. Gene-Environment Interplay in the Comorbidity of PTSD and Disordered Eating
    Karen S Mitchell; Fiscal Year: 2013
    ..my K01 application, The Interplay of Genetic and Environmental Factors in the Comorbidity of PTSD and Disordered Eating, would greatly enhance my predoctoral training in psychology, behavioral genetics, and eating disorders...
  38. Dietary patterns and root caries risk
    ELIZABETH A KAYE; Fiscal Year: 2010
    ..The findings may help to define healthy eating patterns that reduce the risk of root decay.
  39. Human CYP1A1, diet and dioxin-induced hypertension
    Mary K Walker; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The American Heart Association recognizes that eating fish provides significant protection from developing cardiovascular disease and these benefits are derived from ..
  40. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2012
    ..voice commands, tongue-touch keypads, or chin- operated joysticks, can be awkward and can interfere with talking, eating, and normal social interaction...
  41. Inflammatory Cytokine regulation of POMC and Orexin neurons in cachexia.
    AARON GROSSBERG; Fiscal Year: 2012
    ..This research is designed to understand how disease causes these devastating reductions in eating and activity level as a means to develop new therapies.
  42. Analysis of associations between anemia correction in CKD and mortality: CHOIR
    LYNDA ANNE MARIE SZCZECH; Fiscal Year: 2010
    ..improves most quality of life parameters including energy and activity level, functional ability, sleep and eating behavior, health status, satisfaction with health, sex life, well- being, psychological effect, life satisfaction, ..
  43. Intestinal satiation in Roux-en-Y gastric bypass rats: brain mechanisms and sex d
    Thomas Alexander Lutz; Fiscal Year: 2013
    ..The mechanisms through which RYGB increases satiation and reduces eating and body adiposity are poorly understood...
  44. Phosphodiesterase-3B signaling in the Hypothalamus and Obesity
    Abhiram Sahu; Fiscal Year: 2013
    ..resistance and obesity, and therefore will be relevant to the development of therapeutic approaches to obesity and eating disorders...
  45. Melanin-Concentrating Hormone: Ancestral Role in Feeding & Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2010
    ..slow eating, and the hedonistic influence of food...
  46. IL12 Gene Therapy For Enhancing Therapeutic Efficacy of Bleomycin Against Oral Tu
    Shulin Li; Fiscal Year: 2013
    ..affects patient quality of life by removing essential organs, tissues, and nerves which affect breathing, eating, communicating, and social activity...
  47. Effect of Circulating Glucose on Eating Behavior and Brain Activation in Diabetes
    RENATA D BELFORT DE AGUIAR; Fiscal Year: 2013
    ..Sherwin's supervision, involved the use of the insulin clamp technique, eating behavior questionnaires (modified from the addiction research field), and measurement of brain activation by ..
  48. Changes in neural response to eating after bariatric surgery: MRI results
    Thomas A Wadden; Fiscal Year: 2013
    ..In addition, we will serially measure postprandial changes in appetite-regulating hormones and examine the relationships between neural and endocrine response to food consumption. ..
  49. Translational Research on Addiction to Palatable Food
    Nicole M Avena; Fiscal Year: 2013
    ..been using preclinical models to study the unique theory that overeating of palatable foods, in the form of binge eating, can resemble an "addiction" to food, with concomitant behaviors and neurochemical changes that are like those ..
  50. Regulation of Brain Signaling After Bariatric Surgery
    Jonathan Q Purnell; Fiscal Year: 2010
    ..Finally, subgroups with polymorphisms of the dopamine D2 receptor and those with persistent binge eating behavior are hypothesized to be less responsive to effects of hormonal manipulation on brain fMRI response, to ..
  51. Anorexia Nervosa: Regional Brain Abnormalites and Relationship to Outcome
    LAURIE MAY MCCORMICK; Fiscal Year: 2013
    ..The University of Iowa Hospitals and Clinics has a well established eating disorders program for recruiting potential subjects as well as the neuroimaging resources and excellent mentors ..
  52. A Novel Therapy for Radiation-Induced Xerostomia Using Human Salivary Stem Cells
    QUYNH THU XUAN LE; Fiscal Year: 2012
    ..aims to spare one parotid gland, has resulted in some improvement of stimulatory salivary function, such as with eating. However, IMRT cannot spare the SMG glands, which are crucial for resting salivary function throughout the day, ..
  53. Dietary control of angiogenesis in retinopathy models
    Lois Smith; Fiscal Year: 2013
    ..SUMMARY: These studies will determine for retinopathy: i) the relative importance of ?3 vs. ?6 PUFA in diet (is eating ?3PUFA (fish) better than not eating ?6 PUFA (meat)?) ii) the positive and negative contributions of enzymatic ..
  54. Dendritic Spines on AgRP Neurons as Communication Hubs Controlling Feeding
    Dong Kong; Fiscal Year: 2013
    ..This is unfortunate because defective synaptic transmission on these neurons could also contribute to eating disorders...
  55. Placebo Effects in the Treatment of Depression: Cognitive and Neural Mechanisms
    Bret R Rutherford; Fiscal Year: 2013
    ..New York City and has active research programs in a variety of areas, including anxiety and depressive disorders, eating disorders, schizophrenia, suicide, personality disorders, brain imaging, molecular genetics, developmental ..
  56. Endogenous G-Protein Coupled Receptor Antagonists
    Carrie Haskell-Luevano; Fiscal Year: 2012
    ..This research project proposes to generate knowledge for the rational design of molecules as potential therapeutic agents to prevent or treat the diseases associated with over or under eating.
  57. Distress Tolerance Treatment for Weight Concern in Smoking Cessation Among Women
    Erika Litvin Bloom; Fiscal Year: 2013
    ..will include distress tolerance, self-efficacy for smoking cessation, weight and body image concern, affect, and eating in response to cognitive and affective triggers...
  58. Mothers in Motion Program to Prevent Weight Gain in Overweight/Obese WIC Mothers
    Mei Wei Chang; Fiscal Year: 2013
    ..gain among African American (AA) and white overweight/obese WIC mothers18- 39 years old by promoting healthy eating, physical activity, and stress management...
  59. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ..S. population, and the fundamental issue of obesity is a regulation disorder of eating and energy output, which is largely controlled by the central nervous system...
  60. Acceptance-based Group Intervention for Binge Eating
    Niloofar Afari; Fiscal Year: 2012
    ..Obesity and binge eating are independently related to a number of physical and mental health co-morbidities such as diabetes, coronary ..
  61. Environmental Triggers of Eating Seizures in Nodding Syndrome
    Peter S Spencer; Fiscal Year: 2013
    ..uncontrollable, rhythmic nodding of the head shortly after beginning to eat their local diet, a phenomenon termed "eating seizures/epilepsy"...
  62. Modifying Physical Activity and Sedentary Behavior via Mobile Phone Technology
    Abby C King; Fiscal Year: 2010
    ..g., body weight, resting blood pressure and heart rate) and other relevant health behaviors (TV-related eating) will be assessed...
  63. Family Therapy for Adolescent Bulimia Nervosa
    Daniel le Grange; Fiscal Year: 2005
    Bulimia nervosa (BN) is a disabling eating disorder and affects as many as 2% of young women. It is a major source of psychiatric and medical morbidity that often impairs several areas of functioning...
  64. Adapting a web-based eating disorder program for oral health training
    Herbert H Severson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Adapting a web-based eating disorder program for oral health training Abstract This application addresses broad Challenge Area (01): Behavior, Behavioral Change, and Prevention, and specific Challenge ..
  65. APPETITE FOCUSED CBWL FOR BINGE EATING DISORDERS
    Linda Craighead; Fiscal Year: 2001
    ..in Community samples, and 30% of those in hospital-affiliated weight loss programs, meet Criteria for binge eating disorder (BED)...
  66. Prenatal Testosterone and Risk for Disordered Eating During Puberty
    KRISTEN CULBERT; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Eating disorders are significant mental health problems that disproportionally affect girls...
  67. Web-Based Training in Eating Disorder Prevention for Dental Professionals
    Herbert Severson; Fiscal Year: 2007
    ..viewed as an early warning system of potential systemic and mental health issues, such as oral manifestations of eating disorders...
  68. GENETIC EPIDEMIOLOGY--ALCOHOL ABUSE IN EATING DISORDERS
    Walter Kaye; Fiscal Year: 1993
    Alcohol abuse or dependency has been reported to occur frequently in patients with eating disorders and in their family members...
  69. Development of a Self-Help Program to Treat Binge Eating in Mexican Americans
    FARY MAHAMEDI CACHELIN; Fiscal Year: 2010
    Women of ethnic minority groups are the most likely to suffer from unmet mental health needs including eating disorders such as binge eating and associated obesity...
  70. Treatment Response in Ethnic Minority Individuals With Binge Eating Disorder
    Heather Thompson Brenner; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Binge eating disorder (BED) is prevalent in the United States and is associated with serious distress and impairment...
  71. Cognitive Therapy via CD ROM for Binge Eating Disorder
    Cynthia Bulik; Fiscal Year: 2003
    DESCRIPTION: Although eating and weight-related disorders are treatable, most afflicted individuals never receive proper treatment...
  72. COGNITIVE RESPONSES TO MEALS IN EATING DISORDERS
    Katherine Halmi; Fiscal Year: 1991
    The overall purpose of this proposal is to investigate the psychological and behavioral responses to meal eating in eating disorder patients and control persons...
  73. Evaluating the Impact of Menu Labeling on Families. Food Choices and Intake
    CHRISTINA ANN ROBERTO; Fiscal Year: 2010
    ..the impact of calorie labels on restaurant menus on the food choices and intake of parents and their children eating a meal together...
  74. Social transition and risk for disordered eating
    Anne Becker; Fiscal Year: 2007
    ..Development Award with a focus on developing expertise in the investigation of sociocultural risk factors for eating disorders by combining perspectives from epidemiology, anthropology, and psychiatry...
  75. DEVELOPING IDENTITY: AN EATING DISORDERS NURSING THERAPY
    Karen Stein; Fiscal Year: 2005
    The eating disorders of anorexia nervosa (AN) and bulimia nervosa(BN) are life-threatening health problems that affect as many as 5 million American females each year...
  76. The Treatment of Binge Eating Disorder
    Scott Crow; Fiscal Year: 2004
    Research over the last few decades has shown that a sub-group of overweight individuals have an abnormal eating pattern best characterized by discrete binge eating episodes...
  77. The Treatment of Binge Eating Disorder
    James Mitchell; Fiscal Year: 2004
    Research over the last few decades has shown that a sub-group of overweight individuals have an abnormal eating pattern best characterized by discrete binge eating episodes...
  78. EATING DISORDERS--GENETIC EPIDEMIOLOGY
    Cynthia Bulik; Fiscal Year: 2000
    ..Kenneth Kendler, Describes a rigorous three year training program in genetic epidemiology with a focus on eating disorders...
  79. Neurochemistry of Stress-Induced Binge Eating
    MARY BOGGIANO; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Binge-eating is a central feature of bulimia nervosa and binge-eating disorder, which affect millions and renders many more susceptible to obesity and related diseases...
  80. Athletics & Eating Problems in Native & Caucasian Youth
    Wesley Lynch; Fiscal Year: 2003
    Current literature indicates that risk factors for eating disorders (ED) among native Americans are poorly understood...