fracture healing

Summary

Summary: The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.

Top Publications

  1. ncbi Fracture healing under healthy and inflammatory conditions
    Lutz Claes
    Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Helmholtzstraße 14, 89081 Ulm, Germany
    Nat Rev Rheumatol 8:133-43. 2012
  2. ncbi Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation
    Louis C Gerstenfeld
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118 2526, USA
    J Cell Biochem 88:873-84. 2003
  3. pmc Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis
    Z S Ai-Aql
    Orthopaedic Surgical Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118, USA
    J Dent Res 87:107-18. 2008
  4. pmc Regenerative effects of transplanted mesenchymal stem cells in fracture healing
    Froilan Granero-Molto
    Departments of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Stem Cells 27:1887-98. 2009
  5. pmc High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing
    Jazia Alblowi
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts, USA
    Am J Pathol 175:1574-85. 2009
  6. ncbi Low-magnitude high-frequency vibration treatment augments fracture healing in ovariectomy-induced osteoporotic bone
    Hong Fei Shi
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Bone 46:1299-305. 2010
  7. ncbi Current concepts of molecular aspects of bone healing
    Rozalia Dimitriou
    Academic Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, St James s University Hospital, Backett Street, LS9 7TF, UK
    Injury 36:1392-404. 2005
  8. ncbi Bone remodeling during fracture repair: The cellular picture
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    Semin Cell Dev Biol 19:459-66. 2008
  9. pmc Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration
    Celine Colnot
    Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco General Hospital, San Francisco, California 94110, USA
    J Bone Miner Res 24:274-82. 2009
  10. ncbi Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures
    Per Aspenberg
    Orthopaedics, Linkoping University, Linkoping, Sweden
    J Bone Miner Res 25:404-14. 2010

Detail Information

Publications330 found, 100 shown here

  1. ncbi Fracture healing under healthy and inflammatory conditions
    Lutz Claes
    Institute of Orthopedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Helmholtzstraße 14, 89081 Ulm, Germany
    Nat Rev Rheumatol 8:133-43. 2012
    ..as observed in patients with rheumatoid arthritis, diabetes mellitus, multiple trauma or sepsis, can increase fracture healing time and the rate of complications, including non-unions...
  2. ncbi Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation
    Louis C Gerstenfeld
    Department of Orthopaedic Surgery, Orthopaedic Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118 2526, USA
    J Cell Biochem 88:873-84. 2003
    b>Fracture healing is a specialized post-natal repair process that recapitulates aspects of embryological skeletal development...
  3. pmc Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis
    Z S Ai-Aql
    Orthopaedic Surgical Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118, USA
    J Dent Res 87:107-18. 2008
    b>Fracture healing and distraction osteogenesis have important applications in orthopedic, maxillofacial, and periodontal treatment...
  4. pmc Regenerative effects of transplanted mesenchymal stem cells in fracture healing
    Froilan Granero-Molto
    Departments of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Stem Cells 27:1887-98. 2009
    ..MSC improved the fracture healing affecting the callus biomechanical properties and such improvement correlated with an increase in cartilage ..
  5. pmc High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing
    Jazia Alblowi
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts, USA
    Am J Pathol 175:1574-85. 2009
    Diabetes interferes with fracture repair; therefore, we investigated mechanisms of impaired fracture healing in a model of multiple low-dose streptozotocin-induced diabetes...
  6. ncbi Low-magnitude high-frequency vibration treatment augments fracture healing in ovariectomy-induced osteoporotic bone
    Hong Fei Shi
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Bone 46:1299-305. 2010
    b>Fracture healing is impaired in osteoporotic bone. Low-magnitude high-frequency vibration (LMHFV) has recently been proven to be osteogenic in osteoporotic intact bone...
  7. ncbi Current concepts of molecular aspects of bone healing
    Rozalia Dimitriou
    Academic Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, St James s University Hospital, Backett Street, LS9 7TF, UK
    Injury 36:1392-404. 2005
    b>Fracture healing is a complex physiological process...
  8. ncbi Bone remodeling during fracture repair: The cellular picture
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    Semin Cell Dev Biol 19:459-66. 2008
    b>Fracture healing is a complex event that involves the coordination of a variety of different processes...
  9. pmc Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration
    Celine Colnot
    Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco General Hospital, San Francisco, California 94110, USA
    J Bone Miner Res 24:274-82. 2009
    ....
  10. ncbi Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures
    Per Aspenberg
    Orthopaedics, Linkoping University, Linkoping, Sweden
    J Bone Miner Res 25:404-14. 2010
    ..The shortened time to healing for teriparatide 20 microg compared with placebo still may suggest that fracture repair can be accelerated by teriparatide, but this result should be interpreted with caution and warrants further study...
  11. pmc The biology of fracture healing
    Richard Marsell
    Department of Orthopaedic Surgery, Uppsala University Hospital, Entrance 61, Uppsala SE 75185, Sweden
    Injury 42:551-5. 2011
    The biology of fracture healing is a complex biological process that follows specific regenerative patterns and involves changes in the expression of several thousand genes...
  12. pmc TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells
    Graeme E Glass
    The Kennedy Institute of Rheumatology, Imperial College, Hammersmith, London W6 8LH, United Kingdom
    Proc Natl Acad Sci U S A 108:1585-90. 2011
    ..of slow-healing fractures, we have previously shown that coverage of the fracture with muscle accelerated fracture healing and increased union strength...
  13. ncbi The effects of local insulin delivery on diabetic fracture healing
    Ankur Gandhi
    Department of Orthopaedics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, MSB G574, Newark, NJ 07103, USA
    Bone 37:482-90. 2005
    ..and late (mineralized tissue, cartilage content and mechanical strength) parameters of diabetic fracture healing without affecting the systemic parameters of blood glucose...
  14. ncbi Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats
    Niels Follak
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Ernst Moritz Arndt University, Greifswald, Germany
    Diabetes Metab Res Rev 21:288-96. 2005
    Type 1 diabetes mellitus (DM) has been shown to alter the properties of bone and impair fracture healing in both humans and animals...
  15. pmc Chemokine expression is upregulated in chondrocytes in diabetic fracture healing
    Jazia Alblowi
    Department of Oral Basic and Clinical Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
    Bone 53:294-300. 2013
    ..We investigated the impact of diabetes on chemokine expression in normal and diabetic fracture healing. Fracture of the femur was performed in streptozotocin-induced diabetic and matched normoglycemic control ..
  16. ncbi Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats
    T Onishi
    Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan
    Bone 22:605-12. 1998
    ..of BMP-2/-4, osteogenic protein-1 (OP-1, also termed BMP-7), and BMP type II receptor (BMPR-II) during rat fracture healing by immunostaining, and thereby elucidate the possible roles of the BMPs and BMPR-II in intramembranous ..
  17. ncbi Fracture healing is accelerated in the absence of the adaptive immune system
    Daniel Toben
    Julius Wolff Institut and Center for Muskuloskeletal Surgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Bone Miner Res 26:113-24. 2011
    b>Fracture healing is a unique biologic process starting with an initial inflammatory response. As in other regenerative processes, bone and the immune system interact closely during fracture healing...
  18. ncbi Effects of calcium supplements on fracture healing in a rat osteoporotic model
    Ahmad Nazrun Shuid
    Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 KL, Malaysia
    J Orthop Res 28:1651-6. 2010
    b>Fracture healing is a complex process, which is further complicated if the bone is osteoporotic...
  19. ncbi Angiogenesis and bone repair
    Richard A D Carano
    Department of Physiology, Genentech, 1 DNA Way MS 42, South San Francisco, CA 94080, USA
    Drug Discov Today 8:980-9. 2003
    ..In this review, the role of osteogenic factors in the adaptive response and interactive function of OB and EC during the multi-step process of bone repair will be discussed...
  20. pmc Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, New York 14642, USA
    J Clin Invest 109:1405-15. 2002
    ..These results provide a model whereby COX-2 regulates the induction of cbfa1 and osterix to mediate normal skeletal repair...
  21. pmc Variability in the assessment of fracture-healing in orthopaedic trauma studies
    Luis A Corrales
    Department of Orthopaedic Surgery, University of California at San Francisco School of Medicine, 500 Parnassus Avenue, MU 320W, San Francisco, CA 94143, USA
    J Bone Joint Surg Am 90:1862-8. 2008
    ..We conducted a systematic review of recent clinical studies of long-bone fracture care that were published in three major orthopaedic journals to identify current definitions of fracture-healing...
  22. ncbi Does adult fracture repair recapitulate embryonic skeletal formation?
    C Ferguson
    Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Ave, San Francisco, USA
    Mech Dev 87:57-66. 1999
    ..Taken together, these data suggest the genetic mechanisms regulating fetal skeletogenesis also regulate adult skeletal regeneration, and point to important regulators of angiogenesis and ossification in bone regeneration...
  23. ncbi Elastic stable intramedullary nailing versus nonoperative treatment of displaced midshaft clavicular fractures-a randomized, controlled, clinical trial
    Vinzenz Smekal
    From the Department of Trauma Surgery and Sports Medicine, Innsbruck Medical University, Innsbruck, Austria
    J Orthop Trauma 23:106-12. 2009
    ..To compare elastic stable intramedullary nailing (ESIN) with nonoperative treatment of fully displaced midshaft clavicular fractures in adults...
  24. ncbi Expression of angiogenic factors during distraction osteogenesis
    D M Pacicca
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, 715 Albany Street, R 205, Boston, MA 02118 2526, USA
    Bone 33:889-98. 2003
    ..A comparison between the patterns of gene expression in fracture healing and distraction osteogenesis revealed similarities; however, the expression of a number of genes showed ..
  25. ncbi The effects of local platelet rich plasma delivery on diabetic fracture healing
    Ankur Gandhi
    New Jersey Institute of Technology, Department of Biomedical Engineering, 323 Martin Luther King Jr Boulevard, Newark, New Jersey 07102, USA
    Bone 38:540-6. 2006
    ..and chondrogenesis) parameters while improving the late (mechanical strength) parameters of diabetic fracture healing. These results suggest a role for PRP in mediating diabetic fracture healing and potentially other high risk ..
  26. ncbi Mid-term outcomes after intramedullary fixation of peritrochanteric femoral fractures using the new proximal femoral nail antirotation (PFNA)
    Yake Liu
    Department of Orthopaedics, The Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong City, Jiangsu Province 226001, PR China
    Injury 41:810-7. 2010
    ..The purpose of the present study was to evaluate the mid-term outcomes of the newly developed implants - proximal femoral nail antirotation (PFNA) for the stabilisation of this type of fracture...
  27. ncbi BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
    Kunikazu Tsuji
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Nat Genet 38:1424-9. 2006
    ..In fact, in bones lacking BMP2, the earliest steps of fracture healing seem to be blocked...
  28. pmc Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Br J Pharmacol 159:1672-80. 2010
    ..a local RAS in bone has not yet been described and there is no information on whether the RAS is involved in fracture healing. Therefore, we studied the expression and function of the key RAS component, angiotensin-converting enzyme (..
  29. pmc TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1
    Rayyan A Kayal
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA, USA
    J Bone Miner Res 25:1604-15. 2010
    To gain insight into the effect of diabetes on fracture healing, experiments were carried out focusing on chondrocyte apoptosis during the transition from cartilage to bone...
  30. ncbi Autologous bone graft: properties and techniques
    Hans Christoph Pape
    Department of Orthopaedic Trauma Surgery, University of Aachen, Aachen, Germany
    J Orthop Trauma 24:S36-40. 2010
    ..This review article summarizes the biologic and mechanical properties of autologous bone grafts, differentiates various autologous bone graft types, and compares them with other bone substitutes...
  31. ncbi The effect of diabetes mellitus on osseous healing
    M Retzepi
    Periodontology Unit, Clinical Research Division, UCL Eastman Dental Institute, London, UK
    Clin Oral Implants Res 21:673-81. 2010
    ..of the present review is to discuss the clinical evidence supporting a higher rate of complications during fracture healing in diabetic patients and the histological evidence indicating impaired potential for intramembranous and ..
  32. ncbi The systemic angiogenic response during bone healing
    Stefan Weiss
    Department of Orthopaedics, University of Heidelberg, Heidelberg, Germany
    Arch Orthop Trauma Surg 129:989-97. 2009
    Angiogenesis is known to be a critical and closely regulated step during bone formation and fracture healing driven by a complex interaction of various cytokines...
  33. ncbi Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats
    Y F Li
    The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No 14, Section 3, Southern Renmin Road, Chendgu, 610041, China
    Osteoporos Int 21:1889-97. 2010
    ..Callus quality was assessed by radiographic, histological, micro-computerized tomography, and biomechanical examinations at 4 and 8 weeks after fracture. Results revealed that systemic applied SR promoted osteoporotic fracture healing.
  34. ncbi Delayed remodeling in the early period of fracture healing in spontaneously diabetic BB/OK rats depending on the diabetic metabolic state
    N Follak
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Ernst Moritz Arndt University, Greifswald, Germany
    Histol Histopathol 19:473-86. 2004
    Several clinical series, analyzing fracture healing in patients with insulin-dependent type 1 diabetes (IDDM) demonstrated significant incidence of delayed union, non-union, and pseudarthrosis...
  35. ncbi Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or -6 in equine osteotomy and ostectomy models
    Akikazu Ishihara
    Comparative Orthopedic Research Laboratories, Department of Veterinary Clinical Sciences, The Ohio State University, 601 Tharp Street, Columbus, Ohio 43210, USA
    J Orthop Res 26:764-71. 2008
    ....
  36. ncbi Overview of the fracture healing cascade
    A M Phillips
    Consultant Trauma and Orthopaedics, Kings Hospital London, Denmark Hill, London SE5 9RS, UK
    Injury 36:S5-7. 2005
    b>Fracture healing is a dynamic process being governed by a variety of cellular elements and stimulating agents...
  37. ncbi Low-magnitude high-frequency vibration accelerates callus formation, mineralization, and fracture healing in rats
    Kwok Sui Leung
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, People s Republic of China
    J Orthop Res 27:458-65. 2009
    b>Fracture healing is a biological regenerative process that follows a well-orchestrated sequence...
  38. pmc Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function
    Elise F Morgan
    Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Bone 44:335-44. 2009
    ..Although previous studies have used CT to quantify and predict fracture healing, it is unclear which of the many CT-derived metrics of callus structure and composition are the most ..
  39. ncbi Impact of smoking on fracture healing and risk of complications in limb-threatening open tibia fractures
    Renan C Castillo
    Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Orthop Trauma 19:151-7. 2005
    Current data show smoking is associated with a number of complications of the fracture healing process. A concern, however, is the potential confounding effect of covariates associated with smoking...
  40. ncbi The effects of low-intensity pulsed ultrasound upon diabetic fracture healing
    Michael Coords
    Department of Orthopaedics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA
    J Orthop Res 29:181-8. 2011
    ..Recent studies demonstrate the utility of pulsed low-intensity ultrasound (LIPUS) to facilitate fracture healing. The current study evaluated the effects of daily application of LIPUS on mid-diaphyseal femoral fracture ..
  41. ncbi Study of thermal effects of ultrasound stimulation on fracture healing
    Walter Hong Shong Chang
    Institute of Biomedical Engineering, Chung Yuan Christian University, Zhong Li, Tao Yuan, Taiwan
    Bioelectromagnetics 23:256-63. 2002
    Low intensity ultrasound stimulation has been used as a strategy to promote fracture healing. This study investigated the mechanism of ultrasound stimulation in enhancing fracture healing...
  42. ncbi Systemic inflammation and fracture healing
    Okan Bastian
    Departments of Surgery, University Medical Center Utrecht, The Netherlands
    J Leukoc Biol 89:669-73. 2011
    ..their pivotal role in the host defense against pathogens, leukocytes are also essential for bone repair, as fracture healing is initiated and directed by a physiological inflammatory response...
  43. ncbi Bone morphogenetic proteins in orthopaedic trauma surgery
    Evan Argintar
    Georgetown University, Dept Orthopedics, 3800 Reservoir Rd, Washington, DC 20007, United States
    Injury 42:730-4. 2011
    b>Fracture healing describes the normal post-traumatic physiologic process of bone regeneration...
  44. ncbi Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women
    Peter Peichl
    Department of Rheumatology, Evangelisches Krankenhaus, Hans Sachs Gasse 10 12, A 1180 Vienna, Austria
    J Bone Joint Surg Am 93:1583-7. 2011
    ..The purpose of the present prospective, randomized, controlled study was to evaluate the effect of PTH 1-84 on the course of pelvic fracture-healing and functional outcome in postmenopausal women...
  45. pmc Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing
    Alayna E Loiselle
    Division of Musculoskeletal Sciences, College of Medicine, Pennsylvania State University, 500 University Dr, Mail Code H089, Hershey, Pennsylvania 17033, USA
    J Orthop Res 31:147-54. 2013
    ..To determine the role of Cx43 in fracture healing, a closed femur fracture was induced in Osteocalcin-Cre+; Cx43(flox/flox) (Cx43cKO) and Cre-; Cx43(flox/flox) ..
  46. ncbi Fracture healing in mice under controlled rigid and flexible conditions using an adjustable external fixator
    Viktoria Röntgen
    Institute of Orthopaedic Research and Biomechanics, Center of Musculoskeletal Research, University of Ulm, Ulm, Germany
    J Orthop Res 28:1456-62. 2010
    Mice are increasingly used to investigate mechanobiology in fracture healing. The need exists for standardized models allowing for adjustment of the mechanical conditions in the fracture gap...
  47. ncbi Influence of internal fixator stiffness on murine fracture healing: two types of fracture healing lead to two distinct cellular events and FGF-2 expressions
    Masaki Ueno
    Department of Orthopaedic Surgery, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Exp Anim 60:79-87. 2011
    ..We compared two types of fracture healing with different callus formations and cellular events using MouseFix(TM) plate fixation systems for murine ..
  48. ncbi Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats
    Marina Komrakova
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch 40, 37075 Goettingen, Germany
    Bone 47:480-92. 2010
    ..the effect of intermittent administration of parathyroid hormone (PTH) (1-34) applied at different regimes on fracture healing and muscle in healthy and ovariectomized (Ovx at 3 months of age) rats...
  49. pmc Angiogenesis is required for stress fracture healing in rats
    Ryan E Tomlinson
    Department of Orthopaedic Surgery, Washington University in St Louis, Saint Louis, MO, USA
    Bone 52:212-9. 2013
    Although angiogenesis and osteogenesis are critically linked, the importance of angiogenesis for stress fracture healing is unknown...
  50. ncbi Trauma-induced inflammation and fracture healing
    Hans Christophe Pape
    Aachen University, Aachen, Germany
    J Orthop Trauma 24:522-5. 2010
    b>Fracture healing is an extremely complex interaction of cells, biologic pathways, and molecules. Certainly, the inflammatory response is one of the initiating factors for bone healing...
  51. ncbi Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage
    Chikara Ushiku
    Department of Orthopedic Surgery, New England Musculoskeletal Institute, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Orthop Res 28:1338-47. 2010
    ....
  52. ncbi Elastic stable intramedullary nailing is best for mid-shaft clavicular fractures without comminution: results in 60 patients
    Vinzenz Smekal
    Department of Trauma Surgery and Sports Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Injury 42:324-9. 2011
    ..Recent studies, however, also report on higher complication rates and specific problems with the use of this technique. This prospective study compares ESIN with non-operative treatment of displaced mid-shaft clavicular fractures...
  53. pmc Accelerated fracture healing in mice lacking the 5-lipoxygenase gene
    Michaele B Manigrasso
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School and Graduate School of Biological Sciences, Newark, USA
    Acta Orthop 81:748-55. 2010
    ..Inflammation is an early response to bone fracture, and ablation of COX-2 activity impairs fracture healing. Arachidonic acid is also converted into leukotrienes by 5-lipoxygenase (5-LO)...
  54. ncbi Platelet-rich plasma (PRP) enhances bone healing in non-united critical-sized defects: a preliminary study involving rabbit models
    S R Kanthan
    Tissue Engineering Group, NOCERAL, Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Injury 42:782-9. 2011
    ..To overcome this problem, the use of platelet-rich plasma (PRP) has been advocated albeit with varying success. To determine the true effectiveness of PRP in treating non-/delayed unions, a study was conducted using (n=12) rabbit models...
  55. ncbi Small animal bone healing models: standards, tips, and pitfalls results of a consensus meeting
    T Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Bone 49:591-9. 2011
    Small animal fracture models have gained increasing interest in fracture healing studies...
  56. ncbi Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model
    Toshiyuki Kitaori
    Kyoto University, Kyoto, Japan
    Arthritis Rheum 60:813-23. 2009
    ..However, its role in bone repair remains unknown. The purpose of this study was to investigate the role of SDF-1 and its receptor, CXCR4, in bone healing...
  57. ncbi The influence of fracture etiology and type on fracture healing: a review of 104 consecutive tibial shaft fractures
    A H Karladani
    Department of Orthopedics Surgery, Sahlgrenska University Hospital, Goteborg University, Sweden
    Arch Orthop Trauma Surg 121:325-8. 2001
    This study was conducted to determine retrospectively the factors which influence fracture healing and risk for nonunion in patients with tibial shaft fractures...
  58. ncbi Electrical stimulation for fracture healing: current evidence
    Christina Goldstein
    Division of Orthopaedics, Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Orthop Trauma 24:S62-5. 2010
    This article provides an overview of the biology behind the use of electrical stimulation in fracture healing and discusses the current methods of electrical bone growth stimulation...
  59. pmc Use and efficacy of bone morphogenetic proteins in fracture healing
    Suzanne N Lissenberg-Thunnissen
    Department of Surgery Traumatology, Leiden University Medical Center, Leiden, The Netherlands
    Int Orthop 35:1271-80. 2011
    ..Next to an overview of the role of the different BMPs, their antagonists and their current applications, special attention is focused on new scientific developments improving the effects of BMP-based therapy for bone repair...
  60. ncbi Effects of α-tocopherol on the early phase of osteoporotic fracture healing
    Ahmad Nazrun Shuid
    Faculty of Medicine, Department of Pharmacology, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300 KL, Malaysia
    J Orthop Res 29:1732-8. 2011
    b>Fracture healing is a complex process, which is more complicated if the bone is osteoporotic...
  61. ncbi The evidence of low-intensity pulsed ultrasound for in vitro, animal and human fracture healing
    Pilar Martínez de Albornoz
    Department of Trauma and Orthopaedic Surgery, FREMAP Hospital, Ctra de Pozuelo 61, 28220 Majadahonda, Madrid, Spain
    Br Med Bull 100:39-57. 2011
    Physical stimulation therapies are currently available to enhance fracture healing.
  62. ncbi The control of fracture healing and its therapeutic targeting: improving upon nature
    David E Komatsu
    InMotion Orthopaedic Research Center, Memphis, Tennessee, USA
    J Cell Biochem 109:302-11. 2010
    ..Consequently, there is a need for efficacious therapeutics for the intervention of fracture healing. Recent studies into the molecular control of fracture repair and advances in the understanding of the ..
  63. ncbi Role of bone morphogenetic proteins and their antagonists in healing of bone fracture
    D Brian Dean
    Department of Orthopaedic Surgery, Saint Louis University, 3635 Vista Avenue, St Louis MO 63110, USA
    Front Biosci (Landmark Ed) 14:2878-88. 2009
    ..Better understanding of the effects of such antagonists in the healing of fractures opens the possibility of enhancing those effects which are exerted solely by treatment with BMP...
  64. ncbi The use of bone-graft substitutes in large bone defects: any specific needs?
    G M Calori
    COR, Orthopaedic Institute, G Pini, University of Milan, Italy
    Injury 42:S56-63. 2011
    ..The purpose of this study was to evaluate the type of materials used and their efficacy for the treatment of large bone defects in traumatology and orthopaedic surgery...
  65. pmc Human early fracture hematoma is characterized by inflammation and hypoxia
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    Clin Orthop Relat Res 469:3118-26. 2011
    ..An effective immune system, especially during the inflammatory phase, putatively influences the quality and likelihood of bone healing. If and how this is reflected within the initial fracture hematoma is unclear...
  66. ncbi Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones
    Michael S Ominsky
    Metabolic Disorders, Amgen Inc, Thousand Oaks, CA 91320, USA
    J Bone Miner Res 26:1012-21. 2011
    Therapeutic enhancement of fracture healing would help to prevent the occurrence of orthopedic complications such as nonunion and revision surgery...
  67. ncbi Experimental osteoporosis induced by ovariectomy and vitamin D deficiency does not markedly affect fracture healing in rats
    Gunhild Melhus
    Institute of Pathology, University of Oslo, and the Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Acta Orthop 78:393-403. 2007
    The question of whether fracture healing and mechanical properties of the callus are influenced by osteoporosis (OP) is still not settled...
  68. ncbi VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis
    Hairong Peng
    Growth and Development Laboratory, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 20:2017-27. 2005
    ..Results indicate that VEGF antagonist inhibited BMP2-elicited bone formation, whereas the delivery of exogenous VEGF enhanced BMP2-induced bone formation and bone healing through modulation of angiogenesis...
  69. ncbi Nonunions treated with autologous preparation rich in growth factors
    Mikel Sanchez
    Unidad de Cirugia Artroscópica UCA, Clinica USP La Esperanza, Vitoria, Spain
    J Orthop Trauma 23:52-9. 2009
    ..To evaluate the clinical safety and efficacy of using a biologic technology known as preparation rich in growth factors (PRGF) for the treatment of nonhypertrophic nonunion...
  70. ncbi Quality of life related to fracture displacement among elderly patients with femoral neck fractures treated with internal fixation
    Jan Tidermark
    Department of Orthopaedics, Stockholm Soder Hospital, Stockholm, Sweden
    J Orthop Trauma 16:34-8. 2002
    ..To determine differences in outcome between undisplaced (Garden I and II) and displaced (Garden III and IV) femoral neck fractures in elderly patients treated with internal fixation...
  71. ncbi Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption
    L C Gerstenfeld
    Orthopaedics Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Bone Miner Res 18:1584-92. 2003
    ..The role of TNF-alpha during fracture healing was examined in wild-type and TNF-alpha receptor (p55(-/-)/p75(-/-))-deficient mice...
  72. pmc Implant-related complications in the treatment of unstable intertrochanteric fractures: meta-analysis of dynamic screw-plate versus dynamic screw-intramedullary nail devices
    L Audige
    AO Clinical Investigation and Documentation, AO ASIF Center, 7270 Davos Platz, Clavadelerstrasse, Switzerland
    Int Orthop 27:197-203. 2003
    ..Iatrogenic femoral fractures associated with the use of DSIN devices represent a rare, but persistent, risk. There was a tendency for less frequent cut-out with intramedullary devices compared with DSP devices...
  73. ncbi Shaft fractures of the clavicle: current concepts
    Vinzenz Smekal
    Department of Trauma Surgery and Sports Medicine, Innsbruck Medical University, Innsbruck, Austria
    Arch Orthop Trauma Surg 129:807-15. 2009
    ..Though, indications for operative management remain controversial. Further prospective randomized comparative clinical trials are necessary for a well-founded risk-benefit analysis...
  74. ncbi The challenge of establishing preclinical models for segmental bone defect research
    Johannes C Reichert
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, 60 Musk Avenue, Kelvin Grove, QLD 4059, Australia
    Biomaterials 30:2149-63. 2009
    ....
  75. ncbi Deficits following nonoperative treatment of displaced midshaft clavicular fractures
    Michael D McKee
    Division of Orthopaedics, Department of Surgery, St Michael s Hospital and the University of Toronto, 55 Queen Street East, Suite 800, Toronto, ON M5C 1R6, Canada
    J Bone Joint Surg Am 88:35-40. 2006
    ....
  76. ncbi Severely suppressed bone turnover: a potential complication of alendronate therapy
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 90:1294-301. 2005
    ..spontaneous nonspinal fractures while on alendronate therapy, six of whom displayed either delayed or absent fracture healing for 3 months to 2 yr during therapy...
  77. ncbi The role of growth factors in the repair of bone. Biology and clinical applications
    Jay R Lieberman
    Department of Orthopaedic Surgery, University of California at Los Angeles Medical Center, 90077, USA
    J Bone Joint Surg Am 84:1032-44. 2002
  78. ncbi The effect of micromovement on callus formation
    T Yamaji
    Department of Orthopaedic Surgery, Fujita Health University, 3-6-10 Otobashi, Nakagawa-ku, Nagoya 454-8509, Japan
    J Orthop Sci 6:571-5. 2001
    ..Large gaps showed the least new bone formation at the fracture site and the lowest flexural rigidity. From the histological analysis, it was found that the flexural rigidity correlated with the new bone area in the periosteal region...
  79. ncbi Operative treatment of midclavicular fractures in 62 elderly patients: knowles pin versus plate
    Yih Shiunn Lee
    Department of Orthopedic Surgery, Taipei City Hospital, Heping Branch, Taipei, Taiwan
    Orthopedics 30:959-64. 2007
    ..02), lower complication rate (P=0.04), and less symptomatic hardware (P=.015). If surgery of mid-third clavicular fractures is indicated, fixation with a Knowles pin has more advantages than plate fixation in elderly patients...
  80. ncbi The role of bone marrow-derived cells in bone fracture repair in a green fluorescent protein chimeric mouse model
    Kazuhiro Taguchi
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Biochem Biophys Res Commun 331:31-6. 2005
    ..We suggest that bone marrow cells migrated outside of the bone marrow and differentiated into osteoblasts to make up the calluses...
  81. ncbi Treatment of reverse oblique and transverse intertrochanteric fractures with use of an intramedullary nail or a 95 degrees screw-plate: a prospective, randomized study
    Christophe Sadowski
    Orthopaedic Service, University Hospital of Geneva, Switzerland
    J Bone Joint Surg Am 84:372-81. 2002
    ..The purpose of this study was to compare the results of intramedullary fixation with those of plate fixation for these intertrochanteric fractures in elderly patients...
  82. ncbi Fracture healing in osteoporotic fractures: is it really different? A basic science perspective
    Peter Giannoudis
    Academic Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, Leeds, UK
    Injury 38:S90-9. 2007
    ..Surprisingly, less importance has been given to investigating fracture healing in osteoporosis...
  83. ncbi Circulating endothelial/skeletal progenitor cells for bone regeneration and healing
    Tomoyuki Matsumoto
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan
    Bone 43:434-9. 2008
    ..Because failures in fracture healing are largely due to poor vascularization among many environmental factors, we highlight the first proof-of-..
  84. pmc Wnt signaling during fracture repair
    Frank J Secreto
    Departments of Orthopedic Surgery and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Curr Osteoporos Rep 7:64-9. 2009
    ..This article reviews recent data demonstrating that Wnt pathways are active during fracture repair and that increasing the activities of Wnt pathway components accelerates bone regeneration...
  85. ncbi The angiogenic peptide pleiotrophin (PTN/HB-GAM) is expressed in fracture healing: an immunohistochemical study in rats
    Wolf Petersen
    Department of Trauma, Hand and Reconstructive Surgery, University Hospital Munster, Germany
    Arch Orthop Trauma Surg 124:603-7. 2004
    Formation of new blood vessels is essential for the process of fracture healing.
  86. pmc Musculoskeletal response to whole-body vibration during fracture healing in intact and ovariectomized rats
    Ewa K Stuermer
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch St 40, 37075 Goettingen, Germany
    Calcif Tissue Int 87:168-80. 2010
    ..The chosen vibration regimen (90 Hz, 0.5 mm, 4 x g acceleration, 15 min twice a day) was effective in improving musculoskeletal tissues in ovariectomized rats but was not optimal for fracture healing.
  87. ncbi Bridging plate osteosynthesis of humeral shaft fractures
    Bruno Livani
    Department of Orthopedics and Traumatology, Faculty of Medical Sciences, State University of Campinas UNICAMP, P O Box 6111, 13070 170 Campinas, SP, Brazil
    Injury 35:587-95. 2004
    ..We had no major complications. All patients recovered good function of the limb without significant residual deformity...
  88. ncbi Locking plates for distal femur fractures: is there a problem with fracture healing?
    Christopher E Henderson
    Orthopaedic Surgery, University of Iowa Hospital and Clinics, Iowa City, IA, USA
    J Orthop Trauma 25:S8-14. 2011
    ..This article reviews the literature on distal femur fractures treated with locking plates to determine the reported rate of healing difficulties...
  89. pmc Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: analyses of MSCIGF autocrine and paracrine regenerative effects
    Froilan Granero-Molto
    Department of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Stem Cells 29:1537-48. 2011
    ..A callus that was basically absent in Irs1(-/-) left untransplanted or transplanted with MSCs. We provided evidence of effects and mechanisms for transplanted MSC(IGF) in fracture repair and potentially to treat nonunions...
  90. ncbi Recombinant human platelet-derived growth factor BB (rhPDGF-BB) and beta-tricalcium phosphate/collagen matrix enhance fracture healing in a diabetic rat model
    Loay Al-Zube
    UMDNJ New Jersey Medical School and Graduate School of Biomedical Sciences, Newark, New Jersey, USA
    J Orthop Res 27:1074-81. 2009
    Diabetes mellitus is a common systemic disease that has been associated with poor fracture healing outcomes. The mechanism through which diabetes impairs bone regeneration is unknown...
  91. ncbi Reverse LISS plates for unstable proximal femoral fractures
    Ching Hou Ma
    Department of Orthopaedics, E Da Hospital I Shou University, No 1, E Da Road, Jiau Shu Tsuen, Yan Chau Shiang, Kaohsiung 824, Taiwan
    Injury 41:827-33. 2010
    ..The surgical technique was simple and safe. We recommend considering the use of this locked-plate device as the alternative management of unstable proximal femoral fractures that are unsuitable for nailing procedures...
  92. ncbi Local transplantation of human multipotent adipose-derived stem cells accelerates fracture healing via enhanced osteogenesis and angiogenesis
    Taro Shoji
    Group of Vascular Regeneration Research, Institute of Biomedical Research and Innovation, Kobe, Hyogo, Japan
    Lab Invest 90:637-49. 2010
    ..On the basis of these evidences, we examined the therapeutic efficacy of hMADS cells for fracture healing in an immunodeficient rat femur non-union fracture model...
  93. pmc A comparison of the effects of ibuprofen and rofecoxib on rabbit fibula osteotomy healing
    J Patrick O'Connor
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA
    Acta Orthop 80:597-605. 2009
    ..to determine whether nominal, continuous inhibition of COX-2 with rofecoxib would differentially affect fracture healing more than cyclical inhibition of COX-2 using ibuprofen, which inhibits COX-1 and COX-2 and has a short half-..
  94. ncbi A hybrid bioregulatory model of angiogenesis during bone fracture healing
    Véronique Peiffer
    Division of Production Engineering, Machine Design and Automation, Department of Mechanical Engineering, Katholieke Universiteit Leuven, Celestijnenlaan 300B, 3001, Leuven, Belgium
    Biomech Model Mechanobiol 10:383-95. 2011
    Bone fracture healing is a complex process in which angiogenesis or the development of a blood vessel network plays a crucial role...
  95. ncbi A health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Germany, and France
    Volker Alt
    Department of Trauma Surgery Giessen University Hospital Giessen Marburg, Site Giessen, Rudolf Buchheim Str 7, 35385 Giessen, Germany
    Injury 40:1269-75. 2009
    ..Return-to-work time for estimation of productivity losses was assumed to correspond with the time of fracture healing. For calculation of secondary interventions costs and productivity losses the respective 2007/2008 national ..
  96. ncbi Promotion of fracture healing by vitamin E in rats
    Cy Turk
    Department of Orthopaedics and Traumatology, Medical Faculty, Erciyes University, Kayseri, Turkey
    J Int Med Res 32:507-12. 2004
    We investigated the effects of the antioxidant alphae-tocopherol on early- and late-phase fracture healing in a rat model. Sixty male Sprague-Dawley rats were randomized into two groups...
  97. ncbi Low-magnitude high-frequency vibration (LMHFV) enhances bone remodeling in osteoporotic rat femoral fracture healing
    Dick Ho Kiu Chow
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, 5 F, Clinical Science Building, Shatin, New Territories, Hong Kong SAR, People s Republic of China
    J Orthop Res 29:746-52. 2011
    Low-magnitude high-frequency vibration (LMHFV) (35 Hz, 0.3 g) accelerates fracture healing by enhancing callus formation and mineralization for both normal and osteoporotic rats in our previous studies...
  98. ncbi Extracorporeal shock wave therapy for nonunion of the tibia
    Eric A Elster
    Combat Wound Initiative, National Naval Medical Center, Bethesda, MD, USA
    J Orthop Trauma 24:133-41. 2010
    ..The objective of this study was to define disease-specific and treatment-related factors of prognostic significance in patients undergoing shock wave therapy for tibia nonunion...
  99. ncbi Remodeling of fracture callus in mice is consistent with mechanical loading and bone remodeling theory
    Hanna Isaksson
    AO Research Institute, Davos, Switzerland
    J Orthop Res 27:664-72. 2009
    During the remodeling phase of fracture healing in mice, the callus gradually transforms into a double cortex, which thereafter merges into one cortex. In large animals, a double cortex normally does not form...
  100. pmc Functional treatment of closed humeral shaft fractures
    J A K Toivanen
    Division of Orthopaedics and Traumatology, Department of Surgery, Tampere University Hospital, PO Box 2000, 33521 Tampere, Finland
    Int Orthop 29:10-3. 2005
    ..Logistic regression analysis revealed the only predictive factor in respect to successful brace treatment was fracture location. No significant difference was found in respect to healing between different AO-type fractures...
  101. ncbi Comparison of intramedullary nailing versus plate-screw fixation of extra-articular metacarpal fractures
    Kagan Ozer
    Department of Orthopedics, Denver Health Medical Center, University of Colorado School of Medicine, Denver, CO, USA
    J Hand Surg Am 33:1724-31. 2008
    ..To compare the clinical and radiographic outcomes of intramedullary nail (IMN) fixation of metacarpal fractures with those of plate-screw (PS) fixation...

Research Grants64

  1. BBP (Bone Morphogenetic Protein Binding Peptide) and Bone Healing
    SAMUEL SCOTT MURRAY; Fiscal Year: 2013
    ..Cortical bone contains the tiny amount of BMP required to initiate fracture healing, but the amount of rhBMP required to induce bone formation is much greater. Wozney, et al...
  2. The Electricidal Effect, a Novel Anti-Biofilm Strategy
    Robin Patel; Fiscal Year: 2013
    ..Notably, direct current has a precedent of being safely used in clinical practice (e.g., to accelerate fracture healing)...
  3. Pharmacological Method to Accelerate Bone Fracture Healing
    J PATRICK O apos CONNOR; Fiscal Year: 2010
    ..Advancing age and other co-morbid conditions, such as diabetes, can greatly increase fracture healing times and reduce overall rates for successful healing...
  4. Correlating and Quantifying Mechanically-induced Bone Cell Microdamage
    Marnie M Saunders; Fiscal Year: 2012
    ..at the cellular level to mechanical loading is critical to eradicating these conditions, as well as improving fracture healing and distraction osteogenesis outcomes, developing bone substitutes for tissue engineering, and improving ..
  5. ADULT STEM CELL SUPPRESSION DUE TO ALCOHOL INDUCED MICROENVIRONMENT ALTERATIONS
    Mandi J Lopez; Fiscal Year: 2010
    ..Chronic alcohol exposure inhibits fracture healing and results in a significantly higher incidence of spinal fusion failures...
  6. Translational Optimization of Bone Regeneration in the Irradiated Mandible
    Steven R Buchman; Fiscal Year: 2013
    ..XRT drastically impairs fracture healing, however, precluding the utilization of DO as a durable reconstructive method for HNC...
  7. Optimizing Normal Collagen Replacement in Osteogenesis Imperfecta
    Sarah L Dallas; Fiscal Year: 2013
    ..However, recent concerns over the potential of these drugs to inhibit bone remodeling and impair fracture healing, as well as the lack of knowledge about the long term consequences of bisphosphonate treatment in children ..
  8. TRAINING IN TRAUMA AND BURN RESEARCH
    RICHARD LOUIS GAMELLI; Fiscal Year: 2013
    ..in aging, 4) wound healing and vascular repair, 5) alcohol induced changes in bone mineral metabolism and fracture healing and 6) ubiquitin- proteosome system in trauma biology...
  9. Enhancement of Fracture Repair by Hematopoietic Stem Cells
    Amanda C LaRue; Fiscal Year: 2013
    ..The contribution of HSC-derived cells to fracture healing will be examined histochemically, biochemically and quantitatively using micro-computed tomography (micro-CT),..
  10. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Fracture healing of a weight bearing bone is unique in that loading of the injured bone is required for effective healing of the bone...
  11. Effects of Aging on Macrophages and Bone Regeneration
    Mary C Nakamura; Fiscal Year: 2013
    ..morbidity and mortality in our aging population particularly because delayed healing and non-union during fracture healing is more common in the elderly...
  12. A Systems Genetics Approach to Fracture Healing
    LOUIS CHARLES GERSTENFELD; Fiscal Year: 2013
    ..b>Fracture healing can be considered a complex trait that is defined by the regain in mechanical competence that allows ..
  13. Mechanisms Underlying Hormonal Regulation of Fracture Repair
    Dolores M Shoback; Fiscal Year: 2013
    ..the communication between chondrocytes, osteoblasts, and osteoclasts during the sequential process of fracture healing, looking first at specific deletions of IGF-I and its receptor in these different cells to determine if and ..
  14. Mechanism of Mitochondrial Dysfunction in Mesenchymal Stem Cells During Aging
    Roman Eliseev; Fiscal Year: 2013
    ..viability due to the MPT disrupt osteogenic potential of aged MSCs, leading to osteoporosis and delayed fracture healing that can be reversed by inhibition of the MPT...
  15. Directing mesenchymal stem cells to bone to augment bone formation
    Wei Yao; Fiscal Year: 2013
    ..in directing the transplanted MSCs in augmenting bone formation in animal models of osteoporosis and fracture healing. We hypothesize that LLP2A-Ale will direct the transplanted MSCs to the bone surfaces and facilitate new bone ..
  16. Defining a myofibroblast/pericyte as a mesenchymal progenitor cell
    Ivo Kalajzic; Fiscal Year: 2013
    ..SMA-CreERT2 mouse crossed with a Rosa26(cag-tdTomato) reporter line in models of tissue repair that include fracture healing and induction of osteogenic potential using ectopic bone formation induced by BMP2, we will evaluate the ..
  17. OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADING
    Matthew J Silva; Fiscal Year: 2013
    ..Bone formation in many contexts (e.g., development, fracture healing) depends critically on the formation of new blood vessels (angiogenesis), yet the role of angiogenesis in ..
  18. BMP-3 Signaling in the Formation and Regulation of Bone
    Vicki Rosen; Fiscal Year: 2009
    ..second reason for our interest in BMP3 are recent reports that correlate changes in BMP3 levels in vivo with fracture healing, mechanical loading of the skeleton, and the loss of bone formation that occurs with aging...
  19. Nanotechnology-based Theranostic Technology for Bone Tissue Engineering
    Balaji Sitharaman; Fiscal Year: 2010
    ..g., frail elderly, spinal cord injury, confined to wheelchairs or bed-rest, experience space travel) during treatment for osteo-integration, fracture healing, osteoporosis and similar diseases.
  20. Genetic Mouse Models of Cartilage Healing
    LINDA J contact SANDELL; Fiscal Year: 2010
    ..In the Department of Orthopaedic Surgery, we have established mouse models of fracture healing, cartilage healing and ligament healing and will perform full thickness cartilage wounds in the test animals...
  21. Notch signaling and bone fracture healing
    MICHAEL IRVING DISHOWITZ; Fiscal Year: 2012
    ..apos;For the first specific aim we will characterize Notch signaling during calvarial defect and tibial bone fracture healing. Notch reporter mice will undergo a 3 mm diameter calvarial defect or bilateral tibial fractures...
  22. Novel Formulations for Injectable Growth Factors
    Bruce Lamb; Fiscal Year: 2010
    ..bone morphogenetic proteins (BMPs) are employed for a range of indications including spinal fusion and fracture healing due to their potent osteogenic activity (Mont et al. 2004)...
  23. The effects of acute binge alcohol exposure on the canonical Wnt signaling pathwa
    KRISTEN LEIGH LAUING; Fiscal Year: 2011
    ..alcohol consumption is a risk factor for osteopenia and fracture-related complications such as delayed fracture healing and fracture nonunion...
  24. The Effects of Alcohol-Induced Oxidative Stress on Bone Fracture Repair
    PHILIP ROPER; Fiscal Year: 2013
    ..bone health, and our laboratory has shown that acute and chronic EtOH administration significantly impairs fracture healing in rodent models. However, the exact mechanism behind these effects of EtOH remains unknown...
  25. Is impaired fracture healing in smokers related to CO exposure?
    John Wixted; Fiscal Year: 2013
    ..widely recognized from both a basic science and a clinical perspective that smoking tobacco adversely affects fracture healing. While this association between poor healing and smoking is clear, the underlying cause of the toxicity in ..
  26. Prevention of Biofilm Related Infections Using a Novel, Broad Spectrum Antimicrob
    ROY DRAKE BLOEBAUM; Fiscal Year: 2013
    ..By scintillation counting and histological analysis, the effects of CSA-13 on tissue and fracture healing will be determined...
  27. Role of osteogenic stem cells in bone regeneration and repair in vivo
    Dongsu Park; Fiscal Year: 2013
    ..a perivascular origin, migrate efficiently to sites of injury, and supply the majority of new osteoblasts in fracture healing. Further, they overlap with a subset of perivascular nestin[unreadable] MSCs...
  28. The role of connective Tissue Growth Factor on BMP9-Induced Osteogenesis
    HUE HAN LUU; Fiscal Year: 2011
    ..formation is a well orchestrated cascade of events that is necessary for normal bone development and repair/fracture healing. The objective of this application is to characterize the role of Connective Tissue Growth Factor (CTGF) on ..
  29. The Role of BMP2 in the Regenerative Effects of MSC in Fracture Repair
    TIMOTHY JOSEPH MYERS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The fracture healing process is impaired in 10-20% of the 6.2 million fractures occurring annually in the United States...
  30. Rapid mobilization of endogenous progenitor cells for bone healing
    CLARE E YELLOWLEY-GENETOS; Fiscal Year: 2013
    ..We propose to mobilize cells during the first three days of fracture healing, at a time when inflammatory cytokines and chemoattractant molecules are released, and cells are thought to ..
  31. ACADEMIC TRAINING IN TRAUMA AND BURNS
    David M Young; Fiscal Year: 2012
    ..Their interests span wound and fracture healing, and angiogenesis and stem cell sciences in tissues including liver and brain...
  32. Repair of large osteoporotic rat calvarial defects with autologous adipose stem c
    Ming Pei; Fiscal Year: 2012
    ..Osteoporosis contributes to decreased bone mass and bone mineral density (BMD) as well as compromised fracture healing rates and bone repair quality...
  33. Adult Multipotent Mesenchymal Stromal Cells for Fracture Repair
    Anna Spagnoli; Fiscal Year: 2013
    ..insulin- like growth factor-I (IGF-I) differentiate into bone cells within the fracture callus and promote fracture healing by inducing more new bone formation than MSC alone...
  34. Osteogenic Repair from Human Pluripotent Stem Cells
    Dan S Kaufman; Fiscal Year: 2013
    ..Stem Cells (iPSCs) offer specific advantages for development of new therapies to improve bone formation and fracture healing. This proposal is designed to test the hypothesis that cells derived from hESCs and iPSCs serve as mesoderm ..
  35. Bone Cell Growth Regulation by Runx2/Cbfa1
    Andre J Van Wijnen; Fiscal Year: 2013
    ..by applicant): Skeletal regenerative medicine promises to mitigate age-related bone loss and support fracture healing but requires manipulation of biological properties of osteogenic progenitor cells...
  36. Self-Applied Wearable Ultrasound Therapy for Osteoarthritis Management in Rural C
    GEORGE KENNETH LEWIS; Fiscal Year: 2013
    ..the mechanical and thermal mechanisms of action in ultrasound have been shown to facilitate wound and bone fracture healing, to promote the penetration of topical ointments into the skin and found to enhance a variety healthcare ..
  37. The Role of COX2 in the Progression of Calcific Aortic Valve Disease
    ELAINE EMILY WIRRIG; Fiscal Year: 2013
    ..COX2-/- mice have delayed fracture healing and defects in osteoblastogenesis...
  38. Cyclooxygenases in Skeletal Repair
    Xinping Zhang; Fiscal Year: 2013
    ..The role of COX-2 extends to fracture healing in aging...
  39. Diabetic Fracture Healing
    Dana T Graves; Fiscal Year: 2013
    ..This points to a previously unrecognized catabolic defect in diabetic fracture healing and suggests that rapid removal of cartilage may reduce the anlage for endochondral bone formation...
  40. The Role of periostin in Bone Formation
    Robyn K Fuchs; Fiscal Year: 2012
    ..from periostin null and wild-type mice challenged with fluid shear stress and PTH, and;4) determine the fracture healing response in periostin null and wild-type mice subject to experimentally-induced long-bone fractures...
  41. Advanced Plate Osteosynthesis Technology to Promote Healing of Bone Fractures
    Michael Bottlang; Fiscal Year: 2012
    ..Research has confirmed that deficient fracture healing observed with locking plates is largely due to their inherent stiffness, which suppresses interfragmentary ..
  42. ELECTROSTATIC SURFACE OPTIMIZATION FOR OSSEOINTEGRATION
    Michele Marcolongo; Fiscal Year: 2000
    ..b>Fracture healing and bony fusion (for example, in the treatment of degenerative disease) can be facilitated by the use of ..
  43. Role of Notch signaling in fracture healing as a function of aging
    KURT DAVID HANKENSON; Fiscal Year: 2012
    ..several lines of evidence suggesting that Notch signaling is an important determinant in bone formation and fracture healing. Additionally, studies have shown that decreased Notch signaling with aging is responsible for reduced muscle ..
  44. Runx1 Control of Bone Resorption during Fracture Repair
    Joseph A Lorenzo; Fiscal Year: 2013
    ..in vivo and (ii) if conditional deletion of Rux1 in precursors but not mature osteoclasts will impair fracture healing. 2. Define the mechanisms underlying Runx1-mediated inhibition of osteoclastogenesis. (Aim 2)...
  45. Enhancement of antimicrobics by electrical current
    Robin Patel; Fiscal Year: 2007
    ..Direct electrical current has already been safely used in humans for fracture healing. Application of direct electric current with antimicrobial chemotherapy in humans has the potential to ..
  46. TRPV4: Mechanosensitivity and Skeletal Dysplasia
    Ching Kung; Fiscal Year: 2013
    ..This work aims towards understanding how ARD mutations can lead to two disparate diseases. In collaboration, we will also use trpV4-/- knock-out mice to test the role of TRPV4 in fracture healing.
  47. Indian Hedgehog Signaling in Osteoblast Differentiation
    Fanxin Long; Fiscal Year: 2013
    ..In addition, we will test the potential roles of Hh signaling in bone homeostasis and fracture healing in adult mice. PUBLIC HEALTH RELEVANCE: Tremendous unmet clinical needs exist in musculoskeletal medicine...
  48. Sun Valley Workshop on Skeletal Biology
    David B Burr; Fiscal Year: 2011
    ..such as rheumatoid arthritis, as well as mechanisms of cartilage and bone repair, the latter including fracture healing. Other sessions involve cellular signaling mechanisms that are important to prevention of bone and cartilage ..
  49. BIOPHYSICAL REGULATION OF CHONDROCYTE DIFFERENTIATION
    Qian Chen; Fiscal Year: 2010
    ..During skeletal development and fracture healing, mechanical load-induced matrix deformation induces the process of chondrocyte proliferation and ..
  50. BioMEMs Sensor for Monitoring Fracture Healing
    Christian Puttlitz; Fiscal Year: 2011
    ..Unfortunately, the course of aberrant fracture healing is not easily diagnosed in the early time period when standard radiographic information of the fracture site ..
  51. OPTIMIZATION FIXATOR STIFFNESS DURING FRACTURE HEALING
    ALFRED BEHRENS; Fiscal Year: 1993
    ..times than the use of stiffer external fixators, and that (2) optimal fixator rigidity in the early part of fracture healing is different from optimal rigidity in the latter part of the healing process...
  52. Engineering Vascularized Bone Tissues By Microfabrication And Scaffolding
    Yunzhi Yang; Fiscal Year: 2013
    ..Often bone grafts are required for reconstructive skeletal procedures to aid fracture healing, bone fusion, implant integration and repair of skeletal defects, but the use of allograft bone is limited by ..
  53. MECHANISM FOR BONE SIALOPROTEIN TO NUCLEATE BIOAPATITE
    RONALD MIDURA; Fiscal Year: 2002
    ..Our understanding of skeletal development, fracture healing, and bone remodeling will be enhanced by insights into the anabolic processes of bone matrix formation and ..
  54. MECHANICAL FACTORS IN CARTILAGE REPAIR
    SHAWN O DRISCOLL; Fiscal Year: 2004
    ..It is felt that these findings will have relevance to other important area of orthopedics, including fracture healing, and have significant potential to impact the care of patients.
  55. INTERFRAGMENTARY STRAIN HYPOTHESIS AND FRACTURE HEALING
    EDWARD CHEAL; Fiscal Year: 1992
    ..known about how the local strain environment influences the vascular and cellular processes that constitute fracture healing. Perren and co-workers provided a comprehensive "interfragmentary strain" hypothesis describing the influence ..
  56. Injectable BMP-2 Formulation for Fracture Healing
    Paul Hamilton; Fiscal Year: 2006
    ..BMP's), rhBMP-2 and rhBMP-7, are currently used in clinical applications to promote spinal fusion and fracture healing (Mont, Ragland et al. 2004). Over 6...
  57. Improving BMP retention and healing in engineered bone
    ELSA BROCHMANN MURRAY; Fiscal Year: 2007
    ..BMPs promote fracture healing, but their use is limited by high cost, rapid diffusion, and short retention times...
  58. Anti-Resorptives for Dysregulated Bone Remodeling in Ol
    Nancy Pleshko Camacho; Fiscal Year: 2005
    ..In addition, it is not known if fracture healing, a biological process that requires extensive resorptive activity, would be compromised in patients treated ..
  59. MODULATION OF OSTEOGENESIS IN AGED RATS--FGF 2
    James Aronson; Fiscal Year: 1999
    ..DO is a variant of fracture healing that stretches the biological process to its natural limits...
  60. Microengineered Osteons for Bone Tissue Engineering
    Yunzhi Yang; Fiscal Year: 2013
    ..Often bone grafts are required for reconstructive skeletal procedures to aid fracture healing, bone fusion, implant integration and repair of skeletal defects, but the use of allograft bone is limited by ..
  61. Lead Toxicity in the Skeleton & Its Role in Osteoporosis
    J Puzas; Fiscal Year: 2007
    ..metal on bone and cartilage function contribute to diseases such as osteoporosis and hinder osteoporotic fracture healing. The program is made up of four projects, two of which are cellular and molecular in nature, one is animal ..
  62. Mechanism of Nicotine Action in the Healing Skeleton
    Michael Zuscik; Fiscal Year: 2009
    ..the effects of nicotine and cigarette smoke on endochondral bone formation using the in vivo model of femur fracture healing in mice...
  63. Role of Musculo-Dynamics in Bone Fluid Flow, Circulation and Adaptation
    Yi Xian Qin; Fiscal Year: 2009
    ..to devise a biomechanically based intervention for treating osteoporosis, muscle atrophy, and accelerating fracture healing or promoting bony ingrowth into prostheses...
  64. Bone Fluid Flow and its Regulatory Role in Adaptation
    Yi Xian Qin; Fiscal Year: 2006
    ..remodeling may help to devise a biomechanically based intervention for treating osteoporosis, accelerating fracture healing or promoting bony ingrowth into prostheses...