wound healing

Summary

Summary: Restoration of integrity to traumatized tissue.

Top Publications

  1. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
  2. ncbi Wound repair and regeneration
    Geoffrey C Gurtner
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 257 Campus Drive, Stanford, California 94305 5148, USA
    Nature 453:314-21. 2008
  3. ncbi Regulation of wound healing by growth factors and cytokines
    Sabine Werner
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Physiol Rev 83:835-70. 2003
  4. ncbi Growth factors and cytokines in wound healing
    Stephan Barrientos
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Wound Repair Regen 16:585-601. 2008
  5. ncbi Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
  6. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
  7. ncbi Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2896-902. 2007
  8. pmc The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 204:3037-47. 2007
  9. ncbi TGF-beta signaling and the fibrotic response
    Andrew Leask
    Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill St, London, UK NW3 2PF
    FASEB J 18:816-27. 2004
  10. pmc Matrix metalloproteinases and the regulation of tissue remodelling
    Andrea Page-McCaw
    Department of Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Rev Mol Cell Biol 8:221-33. 2007

Detail Information

Publications374 found, 100 shown here

  1. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
    ....
  2. ncbi Wound repair and regeneration
    Geoffrey C Gurtner
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 257 Campus Drive, Stanford, California 94305 5148, USA
    Nature 453:314-21. 2008
    ..Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century...
  3. ncbi Regulation of wound healing by growth factors and cytokines
    Sabine Werner
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Physiol Rev 83:835-70. 2003
    Cutaneous wound healing is a complex process involving blood clotting, inflammation, new tissue formation, and finally tissue remodeling...
  4. ncbi Growth factors and cytokines in wound healing
    Stephan Barrientos
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Wound Repair Regen 16:585-601. 2008
    b>Wound healing is an evolutionarily conserved, complex, multicellular process that, in skin, aims at barrier restoration...
  5. ncbi Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
    ..contractile features, is essential for connective-tissue remodelling during normal and pathological wound healing. Yet the myofibroblast still remains one of the most enigmatic of cells, not least owing to its transient ..
  6. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
    ..This is the first observation, to our knowledge, of a tissue-scale H(2)O(2) pattern, and the first evidence that H(2)O(2) signals to leukocytes in tissues, in addition to its known antiseptic role...
  7. ncbi Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2896-902. 2007
    ..Additionally, we argue that this heterogeneity also provides a basis for the broad therapeutic efficacy of MSCs...
  8. pmc The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 204:3037-47. 2007
    ....
  9. ncbi TGF-beta signaling and the fibrotic response
    Andrew Leask
    Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill St, London, UK NW3 2PF
    FASEB J 18:816-27. 2004
    ....
  10. pmc Matrix metalloproteinases and the regulation of tissue remodelling
    Andrea Page-McCaw
    Department of Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Rev Mol Cell Biol 8:221-33. 2007
    ..Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated...
  11. pmc Factors affecting wound healing
    S Guo
    Center for Wound Healing and Tissue Regeneration, Department of Periodontics, College of Dentistry MC 859, University of Illinois at Chicago, 801 S Paulina Ave, Chicago, IL 60612, USA
    J Dent Res 89:219-29. 2010
    b>Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling...
  12. pmc Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    Liwen Chen
    Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e1886. 2008
    Bone marrow derived mesenchymal stem cells (BM-MSCs) have been shown to enhance wound healing; however, the mechanisms involved are barely understood...
  13. ncbi Inflammation in wound repair: molecular and cellular mechanisms
    Sabine A Eming
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:514-25. 2007
    ..In this paper, we review cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair and provide a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response...
  14. ncbi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    T Asahara
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 85:221-8. 1999
    ....
  15. ncbi TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays
    Tobias Gebäck
    Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Biotechniques 46:265-74. 2009
    ..a major role in development, physiology, and disease, and is frequently evaluated in vitro by the monolayer wound healing assay. The assay analysis, however, is a time-consuming task that is often performed manually...
  16. ncbi Epithelial stem cells, wound healing and cancer
    Esther N Arwert
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, UK
    Nat Rev Cancer 12:170-80. 2012
    ..However, the association between stem cells, wound healing and cancer is poorly understood...
  17. pmc Dynamic reciprocity in the wound microenvironment
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA
    Wound Repair Regen 19:134-48. 2011
    ..In this review, we posit that DR is especially meaningful during wound healing as the DR-driven biochemical, biophysical, and cellular responses to injury play pivotal roles in regulating ..
  18. ncbi Formation and function of the myofibroblast during tissue repair
    Boris Hinz
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Invest Dermatol 127:526-37. 2007
    It is generally accepted that fibroblast-to-myofibroblast differentiation represents a key event during wound healing and tissue repair...
  19. ncbi Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis
    Yaojiong Wu
    161 HMRC, University of Alberta, 113 Street and 87 Avenue, Edmonton, Alberta T6G 2E1, Canada
    Stem Cells 25:2648-59. 2007
    ..In this study, we examined the benefit of bone marrow-derived mesenchymal stem cells (BM-MSCs) in wound healing. Using an excisional wound splinting model, we showed that injection around the wound and application to the ..
  20. ncbi Inflammatory cells during wound repair: the good, the bad and the ugly
    Paul Martin
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK BS8 1TD
    Trends Cell Biol 15:599-607. 2005
    ....
  21. ncbi Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
    Mayumi Ito
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 447:316-20. 2007
    ..These findings suggest treatments for wounds, hair loss and other degenerative skin disorders...
  22. ncbi Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    Hugo J Snippert
    Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 327:1385-9. 2010
    ..Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell...
  23. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
    ..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring...
  24. pmc Human skin wounds: a major and snowballing threat to public health and the economy
    Chandan K Sen
    Department of Surgery, The Ohio State University Comprehensive Wound Center, Columbus, Ohio 43210, USA
    Wound Repair Regen 17:763-71. 2009
    ..An additional burden of wound healing is the problem of skin scarring, a $12 billion annual market...
  25. ncbi Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
    Mayumi Ito
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, M8 Stellar Chance Building, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:1351-4. 2005
    ..Our findings have implications for both gene therapy and developing treatments for wounds because it will be necessary to consider epidermal and hair follicle stem cells as distinct populations...
  26. ncbi Peripheral blood fibrocytes: differentiation pathway and migration to wound sites
    R Abe
    Laboratory of. Vascular Biology and Medical Biochemistry, The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 166:7556-62. 2001
    ..we demonstrate that TGF-beta1 (1-10 ng/ml), an important fibrogenic and growth-regulating cytokine involved in wound healing, increases the differentiation and functional activity of cultured fibrocytes...
  27. ncbi Wound healing: an overview of acute, fibrotic and delayed healing
    Robert F Diegelmann
    Department of Biochemistry, Anatomy, Emergency Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0614, USA
    Front Biosci 9:283-9. 2004
    ..By understanding the functional relationships of these biological processes of normal compared to abnormal wound healing, hopefully new strategies can be designed to treat the pathological conditions.
  28. ncbi Differential roles of macrophages in diverse phases of skin repair
    Tina Lucas
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Immunol 184:3964-77. 2010
    ..These results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events...
  29. ncbi Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds
    Vincent Falanga
    Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island 02908, USA
    Tissue Eng 13:1299-312. 2007
    ..These findings indicate that autologous bone marrow-derived MSC can be safely and effectively delivered to wounds using a fibrin spray system...
  30. pmc STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    Geethanjali Pickert
    Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
    J Exp Med 206:1465-72. 2009
    ..analysis indicated that STAT3 regulates the cellular stress response, apoptosis, and pathways associated with wound healing in IECs...
  31. ncbi Biofilms in chronic wounds
    Garth A James
    Center for Biofilm Engineering, Montana State University Bozeman, Bozeman, Montana 59717, USA
    Wound Repair Regen 16:37-44. 2008
    ..Bacterial biofilm prevalence in specimens from chronic wounds relative to acute wounds observed in this study provides evidence that biofilms may be abundant in chronic wounds...
  32. ncbi Macrophages in skin injury and repair
    Babak Mahdavian Delavary
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunobiology 216:753-62. 2011
    ..Macrophages play a central role in all stages of wound healing and orchestrate the wound healing process...
  33. pmc Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing
    Lucy V Norling
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 186:5543-7. 2011
    ..These findings indicate that humanized NPs, termed nano-proresolving medicines, are mimetics of endogenous resolving mechanisms, possess potent beneficial bioactions, can reduce nanotoxicity, and offer new therapeutic approaches...
  34. ncbi Molecular pathology of wound healing
    Toshikazu Kondo
    Department of Forensic Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Japan
    Forensic Sci Int 203:93-8. 2010
    Skin-wound healing is an orchestrated biological phenomena consisting of three sequential phases, inflammation, proliferation, and maturation...
  35. ncbi Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice
    Zi Qing Lin
    Faculty of Forensic Medicine, China Criminal Police College, Shenyang, China
    J Leukoc Biol 73:713-21. 2003
    To clarify interleukin (IL)-6 roles in wound healing, we prepared skin excisions in wild-type (WT) and IL-6-deficient BALB/c [knockout (KO)] mice. In WT mice, the wound area was reduced to 50% of original size at 6 days after injury...
  36. pmc Impaired wound healing in mouse models of diabetes is mediated by TNF-alpha dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1)
    M F Siqueira
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA, USA
    Diabetologia 53:378-88. 2010
    The role of TNF-alpha in impaired wound healing in diabetes was examined by focusing on fibroblasts.
  37. ncbi Keratinocyte-fibroblast interactions in wound healing
    Sabine Werner
    Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, Honggerberg, Zurich, Switzerland
    J Invest Dermatol 127:998-1008. 2007
    ..As the phenotype of fibroblasts from different tissues or body sites becomes better defined, we may understand their individual contribution in wound healing in more detail and possibly explain different clinical outcomes.
  38. pmc Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila
    Michelle T Juarez
    Section of Cell and Developmental Biology, Division of Biology, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 7:e1002424. 2011
    ..The Drosophila embryonic epidermis provides an excellent system to study genes that regulate wound healing processes...
  39. pmc Whey protein enhances normal inflammatory responses during cutaneous wound healing in diabetic rats
    Hossam Ebaid
    Department of Zoology, College of Science, King Saud University, P, O, Box 2455, Riyadh 11451, Saudi Arabia
    Lipids Health Dis 10:235. 2011
    Prolonged wound healing is a complication of diabetes that contributes to mortality. Impaired wound healing occurs as a consequence of excessive reactive oxygen species (ROS) production...
  40. pmc The phenotype of murine wound macrophages
    Jean M Daley
    Division of Surgical Research, Rhode Island Hospital, Providence, RI 02903, USA
    J Leukoc Biol 87:59-67. 2010
    ..Wound macrophages exhibit a complex phenotype,which includes traits associated with alternative and classical activation and changes as the wound matures.The wound macrophage phenotype does not require IL-4 or IL-13...
  41. pmc Selective and specific macrophage ablation is detrimental to wound healing in mice
    Rita Mirza
    Department of Kinesiology and Nutrition, Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Pathol 175:2454-62. 2009
    Macrophages are thought to play important roles during wound healing, but definition of these roles has been hampered by our technical inability to specifically eliminate macrophages during wound repair...
  42. pmc An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
    Anca Sindrilaru
    Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany
    J Clin Invest 121:985-97. 2011
    ..and induced a p16(INK4a)-dependent senescence program in resident fibroblasts, eventually leading to impaired wound healing. This study provides insight into the role of what we believe to be a previously undescribed iron-induced ..
  43. ncbi Quantitative and reproducible murine model of excisional wound healing
    Robert D Galiano
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Surgery, New York University Medical Center, 560 First Avenue, New York, NY 10016, USA
    Wound Repair Regen 12:485-92. 2004
    The goal of animal wound healing models is to replicate human physiology and predict therapeutic outcomes. There is currently no model of wound healing in rodents that closely parallels human wound healing...
  44. ncbi Parallels between tissue repair and embryo morphogenesis
    Paul Martin
    Department of Physiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Development 131:3021-34. 2004
    b>Wound healing involves a coordinated series of tissue movements that bears a striking resemblance to various embryonic morphogenetic episodes. There are several ways in which repair recapitulates morphogenesis...
  45. ncbi Pathophysiology of acute wound healing
    Jie Li
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Clin Dermatol 25:9-18. 2007
    b>Wound healing is a complex process that can be divided into at least 3 continuous and overlapping processes: an inflammatory reaction, a proliferative process leading to tissue restoration, and, eventually, tissue remodeling...
  46. pmc The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing
    R N Rashmi
    Institute of Biochemistry I, Medical Faculty, University of Cologne, Cologne, Germany
    Nucleus 3:172-86. 2012
    ..To elucidate its physiological role we studied wound healing in Nesprin-2 Giant deficient mice and found that a loss of the protein affected wound healing particularly at ..
  47. ncbi Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing
    Nobuyuki Ebihara
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:8549-57. 2011
    To investigate the role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing.
  48. pmc Cellular and molecular basis of wound healing in diabetes
    Harold Brem
    Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
    J Clin Invest 117:1219-22. 2007
    ..cell-derived factor-1alpha then recruits these EPCs to the cutaneous wound site, resulting in accelerated wound healing. Thus, Gallagher et al...
  49. ncbi Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice
    Ulrich Hofmann
    University of Wuerzburg, University Clinic, Comprehensive Heart Failure Center, Department of Internal Medicine I, Oberdürrbacherstraße 6, Wurzburg, Germany
    Circulation 125:1652-63. 2012
    ..The role of adaptive immunity, especially CD4(+) T-helper cells, has not yet been systematically investigated in wound healing and remodeling after myocardial infarction (MI)...
  50. ncbi The role of stromal stem cells in tissue regeneration and wound repair
    Thaddeus S Stappenbeck
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 324:1666-9. 2009
    ..In mammalian wounds, stromal stem cells appear to be positioned to perform functions similar to those of blastemal cells, including communication with both the overlying epithelium and the inflammatory cells in the mesenchyme...
  51. pmc A Gαq-Ca²⁺ signaling pathway promotes actin-mediated epidermal wound closure in C. elegans
    Suhong Xu
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Curr Biol 21:1960-7. 2011
    ..protein kinase (MAPK) cascade promotes innate immune responses to wounding but is not required for other aspects of wound healing. We therefore set out to identify additional wound response pathways in C. elegans epidermis.
  52. ncbi Chemokines in cutaneous wound healing
    R Gillitzer
    Department of Dermatology, University of Wurzburg Medical School, Germany
    J Leukoc Biol 69:513-21. 2001
    ..position to integrate inflammatory events and reparative processes and are important modulators of human-skin wound healing. This review will focus preferentially on the role of chemokines during skin wound healing and intends to ..
  53. pmc Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO Rep 11:97-105. 2010
    ....
  54. pmc Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration
    Fang Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Sci Signal 3:ra13. 2010
    ..We report a role for apoptotic cell death in promoting wound healing and tissue regeneration in mice...
  55. ncbi Epidermal stem cells arise from the hair follicle after wounding
    Vered Levy
    Cutaneous Biology Research Center, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    FASEB J 21:1358-66. 2007
    ..It further demonstrates that Shh is not induced in keratinocytes during the wound healing process...
  56. ncbi Hyaluronan: from extracellular glue to pericellular cue
    Bryan P Toole
    Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Cancer 4:528-39. 2004
  57. ncbi Inflammatory processes in muscle injury and repair
    James G Tidball
    Department of Physiological Science, 5833 Life Science Bldg, University of California, Los Angeles, CA 90095, USA
    Am J Physiol Regul Integr Comp Physiol 288:R345-53. 2005
    ....
  58. pmc Collective migration of an epithelial monolayer in response to a model wound
    M Poujade
    Laboratoire Physico Chimie Curie Unité Mixte de Recherche 168, Institut Curie, Centre National de Recherche Scientifique, Universite Pierre et Marie Curie, F 75248 Paris, France
    Proc Natl Acad Sci U S A 104:15988-93. 2007
    ..Experiments performed with autocrine cells constitutively expressing hepatocyte growth factor (HGF) or in the presence of exogenous HGF show a higher average velocity of the border and no leader...
  59. ncbi Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts
    M Fronza
    Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Freiburg, Germany
    J Ethnopharmacol 126:463-7. 2009
    PHARMACOLOGICAL RELEVANCE: Presentation of the scratch assay as a convenient and inexpensive in vitro tool to gain first insights in the wound healing potential of plant extracts and natural compounds.
  60. ncbi Secretory profiles and wound healing effects of human amniotic fluid-derived mesenchymal stem cells
    Byung Sun Yoon
    Laboratory of Cell Function Regulation, College of Life Sciences and Biotechnology, Korea University, Anam Dong, Seongbuk gu, Seoul, Republic of Korea
    Stem Cells Dev 19:887-902. 2010
    ..indicated that AF-MSC-CM contains various cytokines and chemokines that are known to be important in normal wound healing, including IL-8, IL-6, TGF-beta, TNFRI, VEGF, and EGF...
  61. pmc Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Biol 168:567-73. 2005
    ..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues...
  62. pmc Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice
    Ileana Ruxandra Botusan
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:19426-31. 2008
    Relative hypoxia is essential in wound healing since it normally plays a pivotal role in regulation of all the critical processes involved in tissue repair...
  63. ncbi Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN
    Min Zhao
    School of Medical Sciences and Department of Ophthalmology, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Nature 442:457-60. 2006
    b>Wound healing is essential for maintaining the integrity of multicellular organisms...
  64. pmc Periostin is essential for cardiac healing after acute myocardial infarction
    Masashi Shimazaki
    Department of Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    J Exp Med 205:295-303. 2008
    ..Our novel findings show the effects of periostin on recruitment of activated fibroblasts through FAK-integrin signaling and on their collagen fibril formation specific to healing after AMI...
  65. pmc Metalloproteinases and their inhibitors: regulators of wound healing
    Sean E Gill
    Center for Lung Biology, University of Washington, 815 Mercer Street, Seattle, WA 98109, USA
    Int J Biochem Cell Biol 40:1334-47. 2008
    b>Wound healing is a dynamic process that involves a coordinated response of many cell types representing distinct tissue compartments and is fundamentally similar among tissue types...
  66. ncbi Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type
    Mikako Sasaki
    Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7 Kita ku, Sapporo, Japan
    J Immunol 180:2581-7. 2008
    ..Taken together, we have demonstrated that MSCs contribute to wound repair via processes involving MSCs differentiation various cell components of the skin...
  67. ncbi Wound-healing assay
    Luis G Rodriguez
    Department of Molecular Medicine, Cornell University College of Veterinary Medicine, Ithaca, NY, USA
    Methods Mol Biol 294:23-9. 2005
    ..This method mimics cell migration during wound healing in vivo...
  68. ncbi Mechanisms of fibrogenesis
    Tatiana Kisseleva
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0602, USA
    Exp Biol Med (Maywood) 233:109-22. 2008
    Fibrogenesis is a mechanism of wound healing and repair. However, prolonged injury causes deregulation of normal processes and results in extensive deposition of extracellular matrix (ECM) proteins and fibrosis...
  69. ncbi Peripheral blood fibrocytes: enhancement of wound healing by cell proliferation, re-epithelialization, contraction, and angiogenesis
    Huang Kai Kao
    Division of Plastic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Surg 254:1066-74. 2011
    ..To identify the in vitro characteristics and functional properties of fibrocytes and investigate the in vivo mechanism of action of fibrocytes injection in accelerating the cutaneous healing process in diabetic mice...
  70. ncbi Epigenetic regulation of wound healing and fibrosis
    Jelena Mann
    Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Curr Opin Rheumatol 25:101-7. 2013
    b>Wound healing is a normal physiological response to tissue injury which can occur in any organ...
  71. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
    Impaired wound healing is a common complication of diabetes. Although it is well known that both macrophages and blood vessels are critical to wound repair, the role of wound-associated lymphatic vessels has not been well investigated...
  72. ncbi Mesothelial cells: their structure, function and role in serosal repair
    Steven E Mutsaers
    Asthma and Allergy Research Institute and Department of Medicine, University of Western Australia, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Respirology 7:171-91. 2002
    ..In the present review, the current understanding of the structure and function of the mesothelium and the biology of mesothelial cells is discussed, together with recent insights into the mechanisms regulating its repair...
  73. pmc FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing
    Katherine A Owen
    Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e23123. 2011
    ..However, few studies to date have determined how FAK contributes to mucosal wound healing in vivo.
  74. ncbi Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts
    Won Serk Kim
    Division of Stem Cell Research, Prostemics Research Institute, Seoul, Republic of Korea
    J Dermatol Sci 48:15-24. 2007
    ..Whereas ADSCs have potential applications for the repair and regeneration of various damaged tissues, few studies have dealt with the effect of ADSCs on fibroblasts, which play a key role in skin biology...
  75. pmc A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis
    Mark D Bass
    School of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Dev Cell 21:681-93. 2011
    Cell migration during wound healing requires adhesion receptor turnover to enable the formation and disassembly of cell-extracellular matrix contacts...
  76. ncbi Fibroblasts and myofibroblasts: their source, function and role in disease
    Robin J McAnulty
    Centre for Respiratory Research, University College London, Rayne Building, 5 University Street, London, WC1E 6JJ, United Kingdom
    Int J Biochem Cell Biol 39:666-71. 2007
    ..cells which play critical roles regulating extracellular matrices, interstitial fluid volume and pressure, and wound healing. Fibroblast numbers can be maintained or expanded by proliferation of resident populations but in addition, ..
  77. ncbi Inflammation and cancer: back to Virchow?
    F Balkwill
    ICRF Translational Oncology Laboratory, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Lancet 357:539-45. 2001
    The response of the body to a cancer is not a unique mechanism but has many parallels with inflammation and wound healing. This article reviews the links between cancer and inflammation and discusses the implications of these links for ..
  78. pmc Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice
    Machteld J van Amerongen
    University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Pathol 170:818-29. 2007
    Macrophages have been suggested to be beneficial for myocardial wound healing. We investigated the role of macrophages in myocardial wound healing by inhibition of macrophage infiltration after myocardial injury...
  79. ncbi MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology
    Jeremy M Sivak
    Vision Research Laboratories, New England Eye Center, Tufts University School of Medicine, Center for Vision Research, Tufts University, 750 Washington Street, Box 450, 02111, Boston, MA 02111, USA
    Prog Retin Eye Res 21:1-14. 2002
    ..For the cornea, we present recent work on the roles of MMPs during various aspects of wound healing. For the retina, we describe the activities of MMPs in specific disease states from which common principles ..
  80. ncbi Normal cutaneous wound healing: clinical correlation with cellular and molecular events
    Christian L Baum
    Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Dermatol Surg 31:674-86; discussion 686. 2005
    Cutaneous wound healing is a normal physiologic function, observed and described for centuries by those afflicted with wounds and by those caring for them...
  81. pmc MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing
    Noriko Hattori
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 0016, Japan
    Am J Pathol 175:533-46. 2009
    Matrix metalloproteinases (MMPs) have been implicated in wound healing. To analyze the roles of MMP-9 and MMP-13 in wound healing, we generated full-thickness cutaneous wounds in MMP-9 knockout (KO), MMP-13 KO, MMP-9/13 double KO, and ..
  82. ncbi Proteinases in cutaneous wound healing
    M Toriseva
    Department of Dermatology, University of Turku, Turku, Finland
    Cell Mol Life Sci 66:203-24. 2009
    Cutaneous wound healing is a complex and highly coordinated process where a number of different cell types participate to renew the damaged tissue under the strict regulation of soluble and insoluble factors...
  83. pmc Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein-2
    Chunli Yan
    Department of Surgery, The Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Pathol 176:2247-58. 2010
    ..Whether and how EMT occurs in wound healing and fibrosis in human skin remains unknown...
  84. pmc Wound macrophages as key regulators of repair: origin, phenotype, and function
    Samielle K Brancato
    Division of Surgical Research, Department of Surgery, Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Am J Pathol 178:19-25. 2011
    ..in genetically modified mice lacking macrophages have confirmed that these cells are essential to normal wound healing because their depletion results in retarded and abnormal repair...
  85. ncbi Myofibroblasts. I. Paracrine cells important in health and disease
    D W Powell
    University of Texas Medical Branch at Galveston, Departments of Internal Medicine, Physiology, and Biophysics and Pathology, Galveston, Texas 77555, USA
    Am J Physiol 277:C1-9. 1999
    ..Because of their ubiquitous presence in all tissues, myofibroblasts play important roles in various organ diseases and perhaps in multisystem diseases as well...
  86. pmc Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor
    Sasa Vukelic
    Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 285:1980-8. 2010
    ..Here we show a novel mechanism by which FPP inhibits wound healing acting as an agonist for glucocorticoid receptor (GR)...
  87. pmc β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target
    Anna P Lam
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Curr Opin Rheumatol 23:562-7. 2011
    ..Recent investigations implicate Wnt/β-catenin signaling in abnormal wound repair and fibrogenesis. The purpose of this review is to highlight recent key studies that support a role for Wnt/β-catenin signaling in fibrosis...
  88. ncbi Enhancement of wound healing by human multipotent stromal cell conditioned medium: the paracrine factors and p38 MAPK activation
    Tu Lai Yew
    Institute of Oral Biology, Department of Dentistry, National Yang Ming University, Taipei, Taiwan
    Cell Transplant 20:693-706. 2011
    b>Wound healing can be improved by transplanting mesenchymal stem cells (MSCs). In this study, we have demonstrated the benefits of the conditioned medium derived from human MSCs (CM-MSC) in wound healing using an excisional wound model...
  89. pmc Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha
    Katherine A Gallagher
    Department of Surgery, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Clin Invest 117:1249-59. 2007
    Endothelial progenitor cells (EPCs) are essential in vasculogenesis and wound healing, but their circulating and wound level numbers are decreased in diabetes...
  90. ncbi Interactions between extracellular matrix and growth factors in wound healing
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, 32610 0294, USA
    Wound Repair Regen 17:153-62. 2009
    Dynamic interactions between growth factors and extracellular matrix (ECM) are integral to wound healing. These interactions take several forms that may be categorized as direct or indirect...
  91. pmc Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair
    Anne M Hocking
    University of Washington, Campus Box 359796, 300 9th Avenue, Seattle, WA 98104, USA
    Exp Cell Res 316:2213-9. 2010
    ..demonstrating the promise of multipotent mesenchymal stem/stromal (MSCs) for the treatment of impaired wound healing. MSCs are often referred to as mesenchymal stem cells despite concerns that these cells are not truly stem ..
  92. pmc Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing
    Zhao Jun Liu
    The DeWitt Daughtry Family Department of Surgery, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Antioxid Redox Signal 10:1869-82. 2008
    ..cells (EPCs) are the key cellular effectors of postnatal neovascularization and play a central role in wound healing, but their circulating and wound-level numbers are decreased in diabetes, implicating an abnormality in EPC ..
  93. pmc Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration
    Yaojiong Wu
    Life Science Division, Graduate School at Shenzhen, Tsinghua University, Beijing, People s Republic of China
    Stem Cells 28:905-15. 2010
    Our understanding of the role of bone marrow (BM)-derived cells in cutaneous homeostasis and wound healing had long been limited to the contribution of inflammatory cells...
  94. ncbi Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis
    Xu Shi-Wen
    Centre for Rheumatology, Department of Medicine, Hampstead Campus, University College London, Rowland Hill Street, London NW3 2PF, UK
    Cytokine Growth Factor Rev 19:133-44. 2008
    ..Abnormal amplification of CTGF dependent signals results in a failure to terminate tissue repair, leading pathological scarring in conditions such as fibrosis and cancer...
  95. ncbi Defective recruitment, survival and proliferation of bone marrow-derived progenitor cells at sites of delayed diabetic wound healing in mice
    M Albiero
    Department of Clinical and Experimental Medicine, University of Padova, Medical School, Via Giustiniani, 2 35100 Padova, Italy
    Diabetologia 54:945-53. 2011
    ..We tested the hypothesis that diabetes impairs the contribution of BM-derived cells at sites of wound healing.
  96. ncbi Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis
    J Mann
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO166YD, UK
    Cell Death Differ 14:275-85. 2007
    Myofibroblasts are critical cellular elements of wound healing generated at sites of injury by transdifferentiation of resident cells. A paradigm for this process is conversion of hepatic stellate cells (HSC) into hepatic myofibroblasts...
  97. ncbi p53 mutant mice that display early ageing-associated phenotypes
    Stuart D Tyner
    Cell and Molecular Biology Program, Baylor College of Medicine, Houston, TX 77030, USA
    Nature 415:45-53. 2002
    ..A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing...
  98. ncbi Corneal stromal wound healing in refractive surgery: the role of myofibroblasts
    J V Jester
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, 75235-9057, USA
    Prog Retin Eye Res 18:311-56. 1999
    ..To explain variations, recent studies have focused on the role of corneal wound healing in modulating refractive outcomes...
  99. ncbi Epithelial stem cells: a folliculocentric view
    George Cotsarelis
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 126:1459-68. 2006
    ..Bulge cells only contribute to the epidermis during wound healing, but after isolation, when combined with neonatal dermal cells, they regenerate new hair follicles, epidermis, ..
  100. ncbi Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration
    Ryoichi Mori
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Cell Sci 119:5193-203. 2006
    ....
  101. ncbi Regenerative versus reparative healing in tendon: a study of biomechanical and histological properties in fetal sheep
    Pedro K Beredjiklian
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA
    Ann Biomed Eng 31:1143-52. 2003
    ..A better understanding of the mechanisms of fetal healing may lead to novel therapeutic strategies in the clinical setting...

Research Grants77

  1. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    Gautam Ghatnekar; Fiscal Year: 2007
    ..Diabetic patients commonly demonstrate impaired wound healing. Approximately 20 percent of patients with diabetes will develop foot ulceration in their lifetime...
  2. Nitric Oxide Releasing Topical Gel for Burn Wound Healing
    ANJAL SHARMA; Fiscal Year: 2007
    ..Nitric oxide (NO) gas has been shown to play a significant role in the promotion and regulation of diverse wound healing processes, including burn wounds...
  3. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..infections involving biofilms include bacterial endocarditis, cystic fibrosis lung infections, deep wound healing, the current dental caries epidemic, periodontal disease, vaginosis, urinary tract infections, and chronic ..
  4. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..healthcare system and there is an immediate need for improved treatment options that promote and accelerate wound healing while minimizing or inhibiting the risk from infection during the healing process...
  5. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..into polyamines and proline, implicating AAMF as regulators of cellular proliferation and fibrosis during the wound healing response and effector cells of T helper type 2 (TH2) immunity...
  6. TARGETING THE MARCKS-FAMILY PROTEINS TO INHIBIT NEUTROPHIL MIGRATION
    Mary K Sheats; Fiscal Year: 2013
    ..response, such as neutrophils, are essential both to host defense from invading microorganisms and wound healing and repair...
  7. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..Given the strong interest in establishing regenerative capabilities in adult cells in situ to improve wound healing and reduce scarring, a means of stimulating stem cell function in situ using physiologic temporal dosage ..
  8. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..autoimmunity, allograft rejection, the diabetes-metabolic syndrome, hemostasis and thrombosis, and wound healing. The vascular endothelium plays an active and vital role in regulating inflammatory responses and in ..
  9. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    ..g., reperfusion, wound healing, diabetes) that are affected by NO and translation inhibition...
  10. Identifying all Meckel-like ciliopathy genes by established total exome capture a
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..It will allow development of animal models and novel therapeutic approaches to these degenerative diseases. ..
  11. Clinical Development of Hemostatic Agent ClotFoam for Severe Hemorrhage
    Maja Nowakowski; Fiscal Year: 2013
    ..The core fibrin component technology developed by our company could be used by other surgical sealant and wound healing products manufacturers, considerably expanding the option for the treatment of blood loss and wound healing...
  12. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..from existing vasculature, is a key event in many physiological processes, like organ growth and development, wound healing, and reproduction...
  13. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..These advances require a paradigm shift from past studies of wound healing to future studies of developmental biology...
  14. MicroRNA Regulation of Macrophage Polarization in Muscle Regeneration
    Paula K Shireman; Fiscal Year: 2013
    ..Multiple types of macrophages participate in the regenerative process;classically activated (M1), wound healing (M2a) and regulatory (M2c) macrophage subsets are present in skin wounds and regenerating skeletal muscle;..
  15. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ..in breast cancers by a group of proteins known as inflammatory cytokines which are important mediators of wound healing but can also potentiate the metastatic spread of cancer cells...
  16. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ..We will also assess opioid actions on intestinal epithelial cell wound healing by electric cell-substrate impedance sensing...
  17. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Regulated and controlled cell migration is important in development and wound healing whereas uncontrolled motility promotes immune diseases and tumor spread...
  18. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2012
    ..In adults, migratory cell types include the cells of the immune system, fibroblasts during wound healing, and cancer cells during metastasis...
  19. Endothelial Progenitor Cells and Particulate Air Pollution
    Arden Pope; Fiscal Year: 2013
    ..resident pluripotent cells or endothelial progenitor cells (EPCs), which also promote angiogenesis and wound healing. We have recently identified a negative correlation between PM exposure and circulating EPC level...
  20. Mechanism and therapy for arteriovenous malformation
    Suk Paul Oh; Fiscal Year: 2013
    ..which will be applicable for a variety of pathological conditions and diseases, including retinopathy, wound healing, nephropathy, and cancer...
  21. Inhibition of angiogenesis by thrombospondin-1 (A2)
    JOHN W LAWLER; Fiscal Year: 2012
    ..regulates endothelial cell phenotype during the tissue remodeling that is associated with angiogenesis, wound healing and neoplasia...
  22. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
    ....
  23. FIBROBLAST DIFFERENTIATION DURING EYE DEVELOPMENT
    Gary W Conrad; Fiscal Year: 2012
    ..Resulting regeneration and wound healing reactions of surrounding surviving corneal nerves and keratocytes involve cellular migrations within the ..
  24. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2013
    ..In adults, migratory cell types include the cells of the immune system, fibroblasts during wound healing, and cancer cells during metastasis...
  25. Biofilm matrix-degrading enzymes for the treatment and prevention of S. aureus-as
    Jeffrey B Kaplan; Fiscal Year: 2013
    ..Bacteria that colonize wounds can delay wound healing and act as a focus for secondary infections...
  26. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    ..proposal is that the MRL/MpJ mouse, in which ear wounds regenerate, expresses proteins during wound healing that favor regeneration...
  27. Decompressive craniotomy versus medical therapy for refractory intracranial hyper
    Raminder Nirula; Fiscal Year: 2010
    ..Topic, 05-GM-101: Anesthesiology Clinical Pharmacology Sepsis Trauma, Burn, and Peri-operative Injury Wound Healing. Traumatic brain injury (TBI) management centers upon minimizing secondary brain injury primarily through ..
  28. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..from preexisting capillaries, occurs during development and in many reparative processes in adults, such as wound healing. Dysregulation of this process is associated with pathogenesis of a number of diseases including retinopathy ..
  29. Improve Wound Healing with HIF-CA5 DNA Vector and Electroporation
    John W Harmon; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Therapy to Improve Wound Healing with DNA Expression Vector for HIF 11 and Electroporation Impaired wound healing is a tremendous problem for individuals with diabetes...
  30. MOLECULAR REGULATION OF CORNEAL WOUND HEALING
    Fu Shin X Yu; Fiscal Year: 2013
    ..of the laboratory has been to obtain basic information about the molecular and cellular biology of corneal wound healing. The studies in the current grant period demonstrated that epidermal growth factor receptor (EGFR) is the key ..
  31. Multiple Molecular Mechanisms for Adiponectin Therapy in Hepatic Fibrogenesis
    Frank A Anania; Fiscal Year: 2013
    ....
  32. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    ..patients in a wide range of pathological conditions, such as liver cirrhosis, liver fibrosis, renal failure, wound healing, and chemotherapy-induced liver or renal damage...
  33. Distinct roles of CARP target genes in wound healing
    Karinna Almodóvar; Fiscal Year: 2013
    ..crosstalk between cells, MMPs, integrins, and other players determines remodeling and vascularization during wound healing. Current understanding of key transcription factors regulating ECM remodeling is limited...
  34. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2012
    ..Our overall goal is to understand the basic molecular regulation of corneal wound healing and apply that knowledge in the development of even more effective therapies to reduce corneal scarring...
  35. Role of liver fluke granulin in cholangiocarcinogenesis
    Jason P Mulvenna; Fiscal Year: 2013
    ..We have identified a homologue of human granulin, a potent growth factor involved in cell proliferation and wound healing, in the excretory/secretory (ES) products of the parasite. O...
  36. Vaccines to promote Tc-1-based targeting of tumor stroma
    Walter J Storkus; Fiscal Year: 2013
    ..While formation of blood vessels from the surrounding vasculature is typical of wound healing and peripheral neoangiogenesis, similar structures in progressive tumors may also involve the process of ..
  37. Protein inhibitor of galectin-3 to limit fibrosis after myocardial infarction
    MATTHEW LAWRENCE SPRINGER; Fiscal Year: 2013
    ....
  38. Copper transport protein and inflammatory angiogenesis
    Masuko Ushio-Fukai; Fiscal Year: 2013
    ..Copper (Cu), an essential micronutrient, is involved in physiological repair processes such as wound healing and angiogenesis as well as in various pathophysiologies including tumor growth, atherosclerosis and ..
  39. Development of Adult Pluripotent Very Small Embryonic Like (VSEL) Stem Cells to T
    DENIS OVEREND RODGERSON; Fiscal Year: 2013
    ..used extensively to test for potential efficacy of treatments for scleroderma and we propose to employ them to test the potential wound healing capabilities of autologous VSELs in treating difficult to heal skin ulcers in this disease.
  40. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    CHRISTOPHER GORDON THANOS; Fiscal Year: 2011
    ..simultaneously deliver multiple regenerative factors derived from cultured choroid plexus (CP) to accelerate wound healing at low therapeutic doses...
  41. The Pharmacology of Dermal Fibrosis
    Bruce Neil Cronstein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Matrix replacement and repair is required for wound healing but when the process is overly exuberant, as in scar or keloid formation, or when it occurs inappropriately, as in Scleroderma and other ..
  42. DNA Pro-Drug Technology in Localized Wound Healing and Tissue Regeneration
    Arthur A Decarlo; Fiscal Year: 2011
    ..The combination of these recombinant proteins for more sophisticated approaches to wound healing is complicated by the need for separate biologics...
  43. Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
    Jakub Tolar; Fiscal Year: 2013
    ..We propose to define the conditions conducive to wound healing in this severe blistering genodermatosis, but the impact of these studies may not be limited to RDEB...
  44. Hampton University Skin of Color Research Institute Skin of Color Symposium 2011:
    Meena Katdare; Fiscal Year: 2011
    ..Covered topics include cutaneous lupus, melanocytic disorders, keloids/wound healing, aging, cutaneous T cell lymphoma, malignant melanoma, optical properties of skin and advanced imaging ..
  45. Mitochondrial Modulation of Endothelia Function
    John F Keaney; Fiscal Year: 2013
    ..and provide us with the requisite knowledge to utilize mitochondria as a means of manipulating the endothelium in vivo and this knowledge could have wide ranging implications for wound healing, limb ischemia, and tumor metastasis.
  46. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey C Murray; Fiscal Year: 2013
    ..The lowa population Is now being studied for both clinical and tissue changes in wound healing. We will look at the IRF6, BMP4, TFAP2A and FOXE1 genotypes for the role of genotype in predicting wound ..
  47. Development of Extracellular Heat Shock Protein-90 as a Novel Topical Wound Heali
    Wei Li; Fiscal Year: 2013
    ..Thus, there has been a pressing need to develop new and more cost-effective wound healing agents...
  48. The application of human collagen kinetic biomarkers to anti-fibrotic drug develo
    SCOTT M contact TURNER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Fibrosis can be defined as an uncontrolled wound healing response that results in organ dysfunction...
  49. Thrombospondins and other matricellular proteins in tissue organization and homeo
    Joanne E Murphy Ullrich; Fiscal Year: 2010
    ..and lung disease, cancer, musculoskeletal disorders, development, human genetic disease, and inflammation and wound healing. The objective of this meeting is to enhance, inspire and accelerate fundamental research and its ..
  50. Integrin-dependent mechanism of T cell-mediated pulmonary fibrosis
    Irina G Luzina; Fiscal Year: 2012
    ..Therefore, this research is applicable to the VA patient care mission, the designated priority areas of pulmonary disorders, autoimmune disorders, and wound healing and to the designated research area of chronic diseases.
  51. Neutrophil Migration in Three Dimensions
    Jonathan S Reichner; Fiscal Year: 2013
    ..patients to infections with opportunistic pathogens, recurrent infectious episodes and impairment of wound healing. Alternatively, an excessive neutrophil response can result in disease states characterized by collateral ..
  52. Role of Protein Kinase C in Macrophage Activation
    Michelle R Lennartz; Fiscal Year: 2012
    ..Understanding membrane remodeling using phagocytosis as a model system will advance our knowledge of the innate immune system and may be applicable to other cell processes, including tumor metastasis and wound healing.
  53. microRNA Control of Wound Healing
    Chandan K Sen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In the United States, impaired wound healing represents a major public health problem that is rapidly growing because of soaring health care costs, an aging population and a sharp rise in the ..
  54. Role of macrophages in pancreatic islet graft rejection
    Midhat H Abdulreda; Fiscal Year: 2013
    ..and effector T lymphocytes promote conversion of infiltrating M2 macrophages, typically involved in wound healing and tissue remodeling, to M1 macrophages which subserve effector cell function in islet allograft rejection...
  55. A novel therapeutic approach for pressure ulcers
    EDWARD PAUL MONAGHAN; Fiscal Year: 2012
    ..of this class, called ARN077, was recently shown to suppress inflammatory responses in the skin and accelerate wound healing in mice...
  56. Microtubule dynamics during cell polarity and migration
    Torsten Wittmann; Fiscal Year: 2012
    Polarity of the cytoskeleton is essential for many cell behaviors, including directed migration during wound healing and chemotaxis...
  57. Internalization of gap junctions as a regulatory mechanism of direct GJIC
    Matthias M Falk; Fiscal Year: 2013
    ..uncouple from their neighbors) if they need to become migratory (development, tissue differentiation, wound healing, etc.) or need to uncouple for other reasons (mitosis, apoptosis, etc.)...
  58. Mesenchymal Stem Cells To Mitigate and Treat Cutaneous Injury Following Radiation
    William H McBride; Fiscal Year: 2010
    ..In extensive experiments, we showed that skin irradiation compromises wound healing, but perhaps more importantly whole body radiation exposure seriously impacts the healing process by depleting ..
  59. MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCH
    Catherine E Costello; Fiscal Year: 2012
    ..Lyme disease and rheumatoid arthritis (Steere), other infectious organisms (Samuelson and Robbins), and wound healing in the eye (Trinkaus-Randall)...
  60. MATRIX MEDIATORS OF WOUND HEALING
    Paul J Higgins; Fiscal Year: 2010
    ..Our continued clarification of mechanistic controls on PAI-1 gene expression may lead to new targeted therapies for diseases in which excessive or non-resolving angiogenesis is a major pathogenic feature. ..
  61. Transdermal Delivery of Deferoxamine to Prevent and Treat Diabetic Wounds
    Geoffrey C Gurtner; Fiscal Year: 2011
    ..increased risk for impaired tissue recovery following ischemic insult and are known to have severe deficits in wound healing. Diabetic foot ulcers represent one of the most common sequelae of diabetes-associated dysfunction in new ..
  62. Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics
    ERIC L BUCKLAND; Fiscal Year: 2012
    ..with significant potential to aid in the diagnosis and treatment of corneal dystrophies, keratoconus and wound healing with true limbus-to-limbus capabilities...
  63. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
    Abstract: Macrophages play key roles in regulating inflammation, wound healing and innate and acquired immunity. In response to activational stimuli, macrophages produce cytokines and growth factors that mediate these processes...
  64. Mechanisms of Human Dermal Fibroblast Migration
    Wei Li; Fiscal Year: 2013
    ..physiological factor(s) that drives inward migration of dermal and epidermal cells into the wound bed during wound healing? Specifically, what factor(s) is responsible for the lateral migration of epidermal keratinocytes over the ..
  65. WEIBEL PALADE BODY FORMATION AND ROLE IN HEMOSTASIS
    DENISA WAGNER; Fiscal Year: 2007
    ..In the first Aim, new roles of Weibel-Palade body components in inflammation and wound healing will be ad[unreadable] dressed...
  66. CELL MOTILITY AND ADHESION IN CORNEAL WOUND HEALING
    Ilene Gipson; Fiscal Year: 1999
    ..to obtain basic information about the cell biology of corneal epithelial adhesion to the stroma and epithelial wound healing that would lead to improved treatment for persistent epithelial defects and recurrent corneal erosions in ..
  67. Role(s) of VEGF in Resolution of Inflammation
    Manuela M Martins Green; Fiscal Year: 2010
    ..VEGF is a key factor in wound healing and is primarily known for its role in angiogenesis...
  68. Enhanced Cryoprecipiate in Wound Healing
    Edward Shanbrom; Fiscal Year: 2007
    ..of this study is to find out if the topical application of enhanced cryoprecipitate can significantly increase wound healing and thus provide a means to decrease patient morbidity and mortality, and the need for repeated grafting ..
  69. Growth factor delivery patch for wound healing
    Fen Zhang; Fiscal Year: 2005
    ..sustained production and secretion of growth factors, for direct release into the wound site, to promote wound healing. By comparison, other growth factor-based therapies for wound healing rely on application of pre-formed growth ..
  70. Treatment with KZ-41 and OTP promotes wound healing in a radiation combined injur
    MOSTAFA GABER; Fiscal Year: 2009
    ..The objective of our application is to develop a treatment strategy that will promote survival and wound healing in individuals exposed to total body irradiation (TBI) who suffer from traumatic mechanical injury...
  71. WOUND HEALING ACCELERATION USING NATURAL PRODUCTS
    Gerald Hammond; Fiscal Year: 1999
    ..abstract_text> ..
  72. NEW HOMEBOX GENES IN SCARLESS FETAL WOUND HEALING
    Corey Largman; Fiscal Year: 2001
    ..One of the major goals of wound healing research is to identify the factors which facilitate scarless fetal wound healing in order to someday achieve ..
  73. Multivalent Conjugates of Sonic Hedgehog to Accelerate Diabetic Wound Healing
    WESLEY MICHAEL JACKSON; Fiscal Year: 2012
    ..is developing protein-polymer therapeutics to overcome the microvascular consequences of diabetic wound healing. We designed our therapy to complement the standard practice of diabetic ulcer management and to reduce the ..
  74. Bone marrow-derived fibroblasts in skin wound healing
    Omaida C Velazquez; Fiscal Year: 2010
    Bone marrow-derived fibroblasts in skin wound healing. Nearly 25% of all diabetic patients, with foot ulcers, will inevitably progress to major limb amputation...
  75. Nucleic acid delivery of growth factors and heparan sulfate proteoglycans for enh
    April L Ellis; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In chronic wounds, numerous factors contribute to the diminished healing. Wound healing constituents, including heparan sulfate proteoglycans and numerous growth factors, are essential to normal skin ..
  76. PHARMACOLOGIC PROMOTION OF WOUND HEALING
    Bruce Cronstein; Fiscal Year: 2007
    ..We have previously demonstrated that topical application of adenosine A2A receptor agonists promotes more rapid wound healing both in diabetic and normal animals...
  77. Angiogenic Peptide Scaffolds to Enhance Diabetic Wound Healing
    DARIA NARMONEVA; Fiscal Year: 2009
    ..Insufficient vascularization is a major factor contributing to impaired wound healing of diabetic ulcers...