bone remodeling

Summary

Summary: The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.

Top Publications

  1. ncbi Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling
    W B Bowler
    Human Bone Cell Research Group, Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3GE, UK
    Bone 28:507-12. 2001
  2. ncbi Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute and University of California, San Francisco, San Francisco, CA, USA
    N Engl J Med 361:756-65. 2009
  3. pmc The amazing osteocyte
    Lynda F Bonewald
    Department of Oral Biology, University of Missouri Kansas City, Kansas City, MO 64108 2784, USA
    J Bone Miner Res 26:229-38. 2011
  4. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
  5. ncbi OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    Y Y Kong
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 397:315-23. 1999
  6. pmc From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205 7199, USA
    Endocr Rev 31:266-300. 2010
  7. ncbi c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling
    A E Grigoriadis
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Science 266:443-8. 1994
  8. pmc Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    Mathieu Ferron
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 142:296-308. 2010
  9. ncbi Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    Desmond Padhi
    Amgen Inc, Thousand Oaks, CA, USA
    J Bone Miner Res 26:19-26. 2011
  10. ncbi Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
    Hiroshi Takayanagi
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Nat Rev Immunol 7:292-304. 2007

Detail Information

Publications378 found, 100 shown here

  1. ncbi Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling
    W B Bowler
    Human Bone Cell Research Group, Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3GE, UK
    Bone 28:507-12. 2001
    ..In this review the release of ATP by bone cells is discussed in the context of activation of bone remodeling. We provide compelling evidence that nucleotides, acting via P2Y receptors, are potent potentiators of ..
  2. ncbi Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute and University of California, San Francisco, San Francisco, CA, USA
    N Engl J Med 361:756-65. 2009
    ..Given its unique actions, denosumab may be useful in the treatment of osteoporosis...
  3. pmc The amazing osteocyte
    Lynda F Bonewald
    Department of Oral Biology, University of Missouri Kansas City, Kansas City, MO 64108 2784, USA
    J Bone Miner Res 26:229-38. 2011
    ..in bone," this cell has been found to have numerous functions, such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as an endocrine cell...
  4. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
    ..There are multiple mechanisms underlying the regulation of bone remodeling, and these involve not only the osteoblastic and osteoclastic cell lineages but also other marrow cells, in ..
  5. ncbi OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    Y Y Kong
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 397:315-23. 1999
    ..Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo...
  6. pmc From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205 7199, USA
    Endocr Rev 31:266-300. 2010
    ....
  7. ncbi c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling
    A E Grigoriadis
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Science 266:443-8. 1994
    ..These results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases...
  8. pmc Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    Mathieu Ferron
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 142:296-308. 2010
    ..Hence, in a feed-forward loop, insulin signals in osteoblasts activate a hormone, osteocalcin, that promotes glucose metabolism...
  9. ncbi Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    Desmond Padhi
    Amgen Inc, Thousand Oaks, CA, USA
    J Bone Miner Res 26:19-26. 2011
    ....
  10. ncbi Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
    Hiroshi Takayanagi
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Nat Rev Immunol 7:292-304. 2007
    ....
  11. ncbi Mechanisms of bone metastasis
    G David Roodman
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh, School of Medicine Hematology, The University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    N Engl J Med 350:1655-64. 2004
  12. pmc Functions of RANKL/RANK/OPG in bone modeling and remodeling
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Arch Biochem Biophys 473:139-46. 2008
    ..signaling through receptor activator of NF-kappaB (RANK) would have extensive functions beyond regulation of bone remodeling. RANKL/RANK signaling regulates osteoclast formation, activation and survival in normal bone modeling and ..
  13. ncbi Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial
    Jacques P Brown
    Laval University, Le Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    J Bone Miner Res 24:153-61. 2009
    ..Denosumab showed significantly larger gains in BMD and greater reduction in bone turnover markers compared with alendronate. The overall safety profile was similar for both treatments...
  14. pmc Cancer to bone: a fatal attraction
    Katherine N Weilbaecher
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Cancer 11:411-25. 2011
    ..Basic findings of tumour-bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases...
  15. pmc Normal bone anatomy and physiology
    Bart Clarke
    Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, W18 A, 200 1st Street SW, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 3:S131-9. 2008
    ..The bone remodeling process regulates the gain and loss of bone mineral density in the adult skeleton and directly influences ..
  16. pmc Cellular and molecular mechanisms of bone remodeling
    Liza J Raggatt
    Faculty of Health Sciences, The University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Herston 4029, Australia
    J Biol Chem 285:25103-8. 2010
    Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis...
  17. ncbi Osteopontin
    J Sodek
    MRC Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, ON, Canada
    Crit Rev Oral Biol Med 11:279-303. 2000
    ..In this review, we discuss the structural features of OPN that relate to its function in the formation, remodeling, and maintenance of bones and teeth...
  18. ncbi Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass
    Michael R McClung
    Oregon Osteoporosis Center, Providence Portland Medical Center, Portland, OR 97213, USA
    Arch Intern Med 165:1762-8. 2005
    Antiresorptive agents for the treatment of osteoporosis suppress bone remodeling and reestablish bone turnover at a lower rate to reduce bone loss...
  19. pmc Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease
    Ann E Kearns
    Endocrine Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Endocr Rev 29:155-92. 2008
    ..b>Bone remodeling is a spatially coordinated lifelong process whereby old bone is removed by osteoclasts and replaced by bone-..
  20. ncbi Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
    Lorenz C Hofbauer
    Department of Gastroenterology, Philipps University, Marburg, Germany
    JAMA 292:490-5. 2004
    ..This review summarizes the clinical implications of the OPG/RANKL/RANK system for bone and vascular diseases...
  21. ncbi Bone remodeling during fracture repair: The cellular picture
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    Semin Cell Dev Biol 19:459-66. 2008
    ..the initial inflammatory response, soft callus formation, hard callus formation, initial bony union and bone remodeling. However, repair can also be seen to represent a juxtaposition of two distinct forces: anabolism or tissue ..
  22. ncbi Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards
    S Vasikaran
    Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia
    Osteoporos Int 22:391-420. 2011
    ....
  23. ncbi Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use
    Anthony B Hodsman
    University of Western Ontario, St Joseph s Health Care, Room 2F 15, 268, Grosvenor Street, London, Ontario N6A 4V2, Canada
    Endocr Rev 26:688-703. 2005
    ..currently recommended for the management of osteoporosis act mainly to inhibit bone resorption and reduce bone remodeling. PTH and its analog, teriparatide [recombinant human PTH(1-34)], represent a new class of anabolic therapies ..
  24. pmc Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling
    Marcus Watkins
    Department of Internal Medicine and Cell Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biol Cell 22:1240-51. 2011
    ..Thus Cx43 in osteogenic cells is a critical regulator of both arms of the bone remodeling cycle, its absence causing structural changes remindful of aged or disused bone.
  25. pmc Osteocyte RANKL: new insights into the control of bone remodeling
    Jinhu Xiong
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Bone Miner Res 27:499-505. 2012
    ..The goal of this review is to highlight the results of these new studies and discuss their implications for our understanding of bone remodeling.
  26. ncbi Bone remodeling
    Dimitrios J Hadjidakis
    Second Department of Internal Medicine, Propaedeutic and Research Institute, Athens University, Attikon University Hospital, Rimini 1, Haidari 124 62, Greece
    Ann N Y Acad Sci 1092:385-96. 2006
    The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts ..
  27. ncbi Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males
    N A Sims
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Bone 30:18-25. 2002
    ..not ERbeta, led to major changes in circulating levels of estradiol and/or testosterone, indirectly affecting bone remodeling and bone mass...
  28. pmc Molecular biology of bone remodeling: implications for new therapeutic targets for osteoporosis
    J Chris Gallagher
    Creighton University Medical Center, Bone Metabolism Unit, Omaha, NE 68131, USA
    Maturitas 65:301-7. 2010
    ..7 years remarkable advances in molecular biology and genetics have led to a detailed understanding of the bone remodeling cycle and as a result new therapeutic targets for treatment emerged...
  29. ncbi Association of changes in bone remodeling and coronary calcification in hemodialysis patients: a prospective study
    Daniela Veit Barreto
    Department of Internal Medicine, Division of Nephrology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Am J Kidney Dis 52:1139-50. 2008
    ..The aim of this study is to prospectively evaluate the association between bone remodeling disorders and progression of coronary artery calcification (CAC) in hemodialysis patients.
  30. ncbi Back to the future: revisiting parathyroid hormone and calcitonin control of bone remodeling
    F J A de Paula
    Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME 04074 7205, USA
    Horm Metab Res 42:299-306. 2010
    ..the mechanism of action of these agents has lagged behind drug approval, and the role of these hormones in bone remodeling is still not firmly established...
  31. ncbi The central regulation of bone mass, the first link between bone remodeling and energy metabolism
    Gerard Karsenty
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    J Clin Endocrinol Metab 95:4795-801. 2010
    ..led us to hypothesize 10 yr ago that there may be a coordinated regulation, endocrine in nature, of bone remodeling and energy metabolism...
  32. ncbi Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial
    Dennis M Black
    San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
    JAMA 296:2927-38. 2006
    ..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain...
  33. ncbi In vivo effects of modification of hydroxyapatite/collagen composites with and without chondroitin sulphate on bone remodeling in the sheep tibia
    Wolfgang Schneiders
    Department of Trauma and Reconstructive Surgery, University Hospital Carl Gustav Carus, Dresden, Germany
    J Orthop Res 27:15-21. 2009
    The addition of chondroitin sulphate (CS) to bone cements with calcium phosphate has lead to an enhancement of bone remodeling and an increase in new bone formation in small animals...
  34. ncbi Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass
    Henry G Bone
    Michigan Bone and Mineral Clinic, Detroit, Michigan 48236, USA
    J Clin Endocrinol Metab 96:972-80. 2011
    ..Denosumab treatment for 24 months increased bone mineral density (BMD) and reduced bone turnover markers (BTM) in postmenopausal women...
  35. pmc Disorders of bone remodeling
    Xu Feng
    Department of Pathology, Center for Metabolic Bone Disease, The University of Alabama at Birmingham, 35294 0007, USA
    Annu Rev Pathol 6:121-45. 2011
    ..b>Bone remodeling involves the removal of old or damaged bone by osteoclasts (bone resorption) and the subsequent replacement ..
  36. pmc Cellular mechanisms of bone remodeling
    Erik Fink Eriksen
    Department of Clinical Endocrinology, Oslo University Hospital, Aker, Trondheimsveien 235, 0514 Oslo, Norway
    Rev Endocr Metab Disord 11:219-27. 2010
    b>Bone remodeling is a tightly regulated process securing repair of microdamage (targeted remodeling) and replacement of old bone with new bone through sequential osteoclastic resorption and osteoblastic bone formation...
  37. ncbi Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthrosis
    David B Burr
    Department of Anatomy and Cell Biology, Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Osteoarthritis Cartilage 12:S20-30. 2004
    ....
  38. ncbi Biomechanical and molecular regulation of bone remodeling
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University Purdue University, Indianapolis, Indiana 46202, USA
    Annu Rev Biomed Eng 8:455-98. 2006
    ..Together, these cells form temporary anatomical structures, called basic multicellular units, that execute bone remodeling. A number of stimuli affect bone turnover, including hormones, cytokines, and mechanical stimuli...
  39. ncbi Bone loss in inflammatory disorders
    R Hardy
    School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    J Endocrinol 201:309-20. 2009
    ..This review will illustrate these interactions between inflammation and bone metabolism and discuss how these are, and might be, manipulated as therapies for inflammation related bone loss...
  40. ncbi Bone remodeling in post-menopausal osteoporosis
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    J Dent Res 85:584-95. 2006
    ..In the present review, the cellular and molecular mechanisms controlling bone remodeling and the influence of sex hormones on these processes are summarized...
  41. pmc Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling
    Xiangwei Wu
    Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 7:571-80. 2010
    ..Sca-1-positive (Sca-1(+)) bone marrow stromal cells are a skeletal stem cell subset, which are recruited to bone remodeling sites by active TGF-β1 in response to bone resorption...
  42. ncbi Microarchitectural deterioration of cortical and trabecular bone: differing effects of denosumab and alendronate
    Ego Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 25:1886-94. 2010
    The intensity of bone remodeling is a critical determinant of the decay of cortical and trabecular microstructure after menopause...
  43. ncbi Osteoclast-osteoblast communication
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
    Arch Biochem Biophys 473:201-9. 2008
    ..occurs in a basic multicellular unit (BMU) at the initiation, transition and termination phases of bone remodeling. At the initiation phase, hematopoietic precursors are recruited to the BMU...
  44. ncbi Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Bone Miner Res 20:177-84. 2005
    ..find that grouping them into anti-catabolic and anabolic classes based on the mechanisms of their action on bone remodeling and fracture reduction removes ambiguities and provides a relatively straightforward classification...
  45. ncbi Bone remodeling in rheumatic disease: a question of balance
    Nicole C Walsh
    Bone, Joint, Cancer Unit, St Vincent s Institute, Fitzroy, Victoria, Australia
    Immunol Rev 233:301-12. 2010
    ..This fertile area of research bears watching for the identification of novel targets for the prevention of abnormal bone remodeling in inflammatory diseases.
  46. ncbi The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling
    Sandrine Theoleyre
    EA 3822, Inserm ESPRI, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
    Cytokine Growth Factor Rev 15:457-75. 2004
    ..Kwan Tat S, Padrines M, Theoleyre S, Heymann D, Fortun Y. IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev 2004;15:49-60]...
  47. pmc Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle
    Sundar Srinivasan
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle 98104 2499, USA
    J Bone Miner Res 17:1613-20. 2002
    ..We conclude that 10 s of rest between each load cycle of a low-magnitude loading protocol greatly enhances the osteogenic potential of the regimen...
  48. pmc Effects of a single injection of teriparatide on bone turnover markers in postmenopausal women
    M Shiraki
    Department of Internal Medicine, Research Institute and Practice for Involutional Diseases, 1610 1 Meisei, Misato, Azumino, Nagano, 399 8101, Japan
    Osteoporos Int 24:219-26. 2013
    ..Teriparatide caused a transient increase in bone resorption and inhibition of bone formation followed by a subsequent increase in bone formation and a decrease in resorption that lasted at least 1 week...
  49. pmc Effects of PTH treatment on tibial bone of ovariectomized rats assessed by in vivo micro-CT
    J E M Brouwers
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Osteoporos Int 20:1823-35. 2009
    ..Bone was formed in cavities, leading to restoral of nearly cleaved trabeculae. For the first time, effects in PTH-treated rats were analyzed longitudinally...
  50. ncbi Interleukin-11 receptor signaling is required for normal bone remodeling
    Natalie A Sims
    Department of Medicine at St Vincent s Hospital, The University of Melbourne, Fitzroy, Australia
    J Bone Miner Res 20:1093-102. 2005
    ..Furthermore, IL-11 signaling was not required for the effects of estradiol or estrogen deficiency on the mouse skeleton...
  51. ncbi The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis
    Ming Ding
    Orthopedic Research Laboratory, Department of Orthopedics, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 82:77-86. 2008
    ..Treatment with ALN did not significantly change the mechanical properties of the cancellous bone...
  52. pmc Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth
    Rebecca A Mosig
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hum Mol Genet 16:1113-23. 2007
    ..Thus, Mmp2-/- mice provide a valuable biological resource for studying the pathophysiological mechanisms underlying the human disease and defining the in vivo physiological role of MMP-2...
  53. ncbi Early responsiveness of women with osteoporosis to teriparatide after therapy with alendronate or risedronate
    Paul D Miller
    Colorado Center for Bone Research, Lakewood, Colorado 80227, USA
    J Clin Endocrinol Metab 93:3785-93. 2008
    ..The extent of this effect is different for other antiresorptives. This study evaluated the early anabolic effects of teriparatide in postmenopausal women with osteoporosis previously treated with alendronate or risedronate...
  54. ncbi Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada
    Bone 49:559-67. 2011
    ..In this study, we investigated in human OA subchondral bone osteoblasts the modulatory effect of strontium ranelate on the above key factors...
  55. ncbi Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis
    Suhair Jabbar
    Rheumatology Department, The James Cook University Hospital, Middlesbrough, UK
    J Clin Pathol 64:354-7. 2011
    ....
  56. ncbi Thyroid hormone receptor β mediates thyroid hormone effects on bone remodeling and bone mass
    Laurent Emmanuel Monfoulet
    INSERM, U577, and University Victor Segalen, Bordeaux, France
    J Bone Miner Res 26:2036-44. 2011
    ..suggest that TRβ receptors mediate the acute effects produced by transient changes of TH concentrations on bone remodeling, whereas TRα receptors mediate long-term effects of chronic alterations of TH metabolism...
  57. ncbi Markers of bone remodeling and skeletal morbidity in patients with solid tumors metastatic to the skeleton receiving the biphosphonate zoledronic acid
    Giannis Mountzios
    Department of Medical Oncology, 251 General Airforce Hospital, University of Athens, Athens, Greece
    Transl Res 155:247-55. 2010
    ..to evaluate the effect of treatment with the biphosphonate zoledronic acid (ZA) on biochemical markers of bone remodeling and to detect possible correlations of markerlevel changes with skeletal morbidity and clinical outcomes in ..
  58. ncbi Effects of relaxin and estrogens on bone remodeling markers, receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG), in rat adjuvant-induced arthritis
    Teh Yuan Ho
    Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA
    Bone 48:1346-53. 2011
    ..of this study was to investigate whether relaxin (RLX), alone or in combination with estrogens, regulates the bone remodeling markers RANKL and OPG in vivo and in vitro...
  59. ncbi Sustained efficacy and safety of bazedoxifene in preventing fractures in postmenopausal women with osteoporosis: results of a 5-year, randomized, placebo-controlled study
    S L Silverman
    Cedars Sinai Medical Center and University of California, Los Angeles, CA, USA
    Osteoporos Int 23:351-63. 2012
    ..Bazedoxifene significantly increased bone mineral density and reduced bone turnover versus placebo and was generally safe and well tolerated...
  60. ncbi Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys
    Patricia J Masarachia
    Bone Biology Group, Merck Sharp and Dohme Corp, West Point, PA 19486, USA
    J Bone Miner Res 27:509-23. 2012
    ..Taken together, our findings demonstrated that the long-term treatment with ODN effectively suppressed bone turnover without reducing osteoclast number and maintained normal biomechanical properties of the spine of OVX nonhuman primates...
  61. ncbi Osteoblastogenesis regulation signals in bone remodeling
    C Zuo
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Osteoporos Int 23:1653-63. 2012
    b>Bone remodeling is essential for adult bone homeostasis. The failure of this process often leads to the development of osteoporosis, a present major global health concern...
  62. ncbi Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey
    Tara Cusick
    Bone Biology Group, Merck Sharp and Dohme Corp, West Point, PA 19486, USA
    J Bone Miner Res 27:524-37. 2012
    ..The drug provided marked increases in periosteal bone formation and cortical thickness in OVX monkeys, suggesting that CatK inhibition may represent a novel therapeutic approach for the treatment of osteoporosis...
  63. ncbi Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes
    Luigi Gennari
    Department of Internal Medicine Endocrine Metabolic Sciences, and Biochemistry, University of Siena, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 97:1737-44. 2012
    ..Sclerostin is a secreted Wnt antagonist produced by osteocytes that regulates osteoblast activity and thus bone turnover. Its levels increase with age and are regulated by PTH...
  64. pmc Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling
    Guozhi Xiao
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Biol Chem 287:21450-60. 2012
    b>Bone remodeling is a complex process that must be precisely controlled to maintain a healthy life...
  65. ncbi Reactive oxygen species and exercise on bone metabolism: friend or enemy?
    Edith Filaire
    EA4532, laboratoire CIAMS, Universite Paris Sud, Université Orléans, UFRSTAPS, 2, allée du Château, 45067 Orleans Cedex, France
    Joint Bone Spine 79:341-6. 2012
    ..However, the production of ROS increases during demanding exercise. To explore this further, the aim of the present review was to examine bone remodelling in relation to oxidative stress and exercise...
  66. ncbi Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis
    Clifford J Rosen
    Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Am J Med 122:409-14. 2009
    ..This article explores these relationships in the context of a new paradigm with implications for obesity and osteoporosis...
  67. pmc Small body size and extreme cortical bone remodeling indicate phyletic dwarfism in Magyarosaurus dacus (Sauropoda: Titanosauria)
    Koen Stein
    Steinmann Institute Division of Paleontology, University of Bonn, 53115 Bonn, Germany
    Proc Natl Acad Sci U S A 107:9258-63. 2010
    ..The uniquely decreased growth rate and diminutive body size in Magyarosaurus were adaptations to life on a Cretaceous island and show that sauropod dinosaurs were not exempt from general ecological principles limiting body size...
  68. ncbi ASDAS, BASDAI and different treatment responses and their relation to biomarkers of inflammation, cartilage and bone turnover in patients with axial spondyloarthritis treated with TNFα inhibitors
    Susanne Juhl Pedersen
    Rheumatologic Research Unit, Glostrup University Hospital, Copenhagen, Denmark
    Ann Rheum Dis 70:1375-81. 2011
    ....
  69. ncbi Denosumab: a review of its use in the treatment of postmenopausal osteoporosis
    Marit D Moen
    Adis, a Wolters Kluwer Business, North Shore, Auckland, New Zealand
    Drugs Aging 28:63-82. 2011
    ....
  70. ncbi Bone's mechanostat: a 2003 update
    Harold M Frost
    Department of Orthopaedic Surgery, Southern Colorado Clinic, Pueblo, CO 81008, USA
    Anat Rec A Discov Mol Cell Evol Biol 275:1081-101. 2003
    ..The mechanostat hypothesis may have analogs in nonosseous skeletal organs as well...
  71. ncbi Functional significance of strain distribution in the human mandible under masticatory load: numerical predictions
    I Ichim
    Department of Oral Sciences, Otago University, Walsh Building, 310 Great King Street, Dunedin 9001, New Zealand
    Arch Oral Biol 52:465-73. 2007
    ..We then relate the magnitude of these strains to Frost's mechanostat. Our results suggest that the cortical asymmetry of the human mandible is in fact not related to strain patterns generated during mastication...
  72. ncbi Maldaptation of the link between inflammation and bone turnover may be a key determinant of osteoporosis
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:532-7. 2004
    ..Osteoporosis may result from disequilibrium between structural demand for key minerals and their biologic demand during maladaptive states of inflammation...
  73. ncbi Osteoimmunology: interplay between the immune system and bone metabolism
    Matthew C Walsh
    1Department of Pathology and Laboratory Medicine, AFCRI, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Immunol 24:33-63. 2006
    ..Efforts are currently under way to further characterize how these two organ systems overlap and to develop therapeutic strategies that benefit from this understanding...
  74. ncbi Denosumab in postmenopausal women with low bone mineral density
    Michael R McClung
    Providence Portland Medical Center, Portland, Oreg, USA
    N Engl J Med 354:821-31. 2006
    ..The fully human monoclonal antibody denosumab (formerly known as AMG 162) binds RANKL with high affinity and specificity and inhibits RANKL action...
  75. pmc Bisphosphonates cause osteonecrosis of the jaw-like disease in mice
    Yanming Bi
    University of Maryland School of Medicine, 800 W Baltimore Street, Baltimore, MD 21201, USA
    Am J Pathol 177:280-90. 2010
    ..cause of BONJ-like disease in mice, mediated in part by its ability to suppress osseous angiogenesis and bone remodeling. The availability of this novel mouse model of BONJ-like disease will help elucidate the pathophysiology of ..
  76. pmc TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling
    Tao Qiu
    Department of Orthopaedic Surgery, Johns Hopkins Medical Institution, 720 Rutland Avenue, Ross Building 232, Baltimore, Maryland 21205, USA
    Nat Cell Biol 12:224-34. 2010
    ..These studies reveal a previously unrecognized function for TbetaRII and a mechanism for integration of PTH and local growth factor at the membrane receptor level...
  77. pmc New suggestions for the mechanical control of bone remodeling
    J W C Dunlop
    Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, Potsdam 14424, Germany
    Calcif Tissue Int 85:45-54. 2009
    ..This is in disagreement with the commonly used rules having a so-called lazy zone...
  78. ncbi Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression
    A M Parfitt
    Division of Endocrinology and Center for Osteoporosis and Metabolic Bone Disease, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Bone 30:5-7. 2002
  79. ncbi Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression
    Ippei Kanazawa
    Dept of Internal Medicine 1, Shimane Univ Faculty of Medicine, 89 1 Enya cho, Izumo 693 8501, Japan
    Am J Physiol Endocrinol Metab 296:E139-46. 2009
    ..These agents could be candidate drugs that promote bone formation for the treatment of osteoporosis...
  80. ncbi TGF-β in cancer and bone: implications for treatment of bone metastases
    Patricia Juarez
    Department of Medicine, Division of Endocrinology, Indiana University, Indianapolis, IN, USA
    Bone 48:23-9. 2011
    ..Tumor cells co-opt bone cells to drive a feed-forward cycle which disrupts normal bone remodeling to result in abnormal bone destruction or formation and tumor growth in bone...
  81. ncbi The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo
    Kate Vandyke
    Myeloma Research Laboratory, Department of Haematology, Centre for Cancer Biology, Institute of Medical and Veterinary Science, Adelaide, Australia
    J Bone Miner Res 25:1759-70. 2010
    ..These studies show that dasatinib increases trabecular bone volume at least in part by inhibiting osteoclast activity, suggesting that dasatinib therapy may result in dysregulated bone remodeling.
  82. ncbi Expression of vascular endothelial growth factor and the effects on bone remodeling during experimental tooth movement
    S Kohno
    Department of Orthodontics, Hiroshima University Faculty of Dentistry, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    J Dent Res 82:177-82. 2003
    ..These results suggested that VEGF, highly expressed by mechanical stimuli, enhances the number of osteoclasts as a paracrine factor, and that the amount of tooth movement is accelerated by both endogenous VEGF and injected rhVEGF...
  83. pmc Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis
    Naoko Irie
    Department of Microbiology and Immunology, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 284:14637-44. 2009
    ..Here we show that bidirectional ephrinA2-EphA2 signaling regulates bone remodeling at the initiation phase...
  84. ncbi Efavirenz is associated with severe vitamin D deficiency and increased alkaline phosphatase
    Tanya Welz
    Department of HIV Genitourinary Medicine, King s College Hospital, London, UK
    AIDS 24:1923-8. 2010
    ....
  85. ncbi Osteotropic cancers: from primary tumor to bone
    Jeroen T Buijs
    Department of Urology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Lett 273:177-93. 2009
    ..For this reason, this review uses the 'seed and soil' hypothesis as a template to discuss novel insight and developments in the bone metastasis field...
  86. ncbi Evidence that anabolic effects of PTH on bone require IGF-I in growing mice
    N Miyakoshi
    Musculoskeletal Disease Center, J L Pettis VA Medical Center, Loma Linda, California 92357, USA
    Endocrinology 142:4349-56. 2001
    ..These data to our knowledge provide the first direct evidence that the anabolic effects of PTH on bone formation in vivo require IGF-I action in growing mice...
  87. ncbi IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling
    H Huang
    Department of Cell and Developmental Biology, BK21 and DRI, Seoul National University School of Dentistry, Seoul 110 749, Korea
    Cell Death Differ 16:1332-43. 2009
    ..On the basis of these results, we suggest that IL-17 can function as a signal to induce extensive bone turnover by regulating hMSC recruitment, proliferation, motility, and differentiation...
  88. pmc Akt1 in osteoblasts and osteoclasts controls bone remodeling
    Naohiro Kawamura
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 2:e1058. 2007
    ..The molecular network found in this study will provide a basis for rational therapeutic targets for bone disorders...
  89. ncbi Biochemical and mechanical properties of subchondral bone in osteoarthritis
    Allen J Bailey
    Collagen Research Group, University of Bristol, Bristol, UK
    Biorheology 41:349-58. 2004
    ....
  90. ncbi Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption
    Natalie A Sims
    St Vincent s Institute and the Department of Medicine at St Vincent s Hospital, The University of Melbourne, Australia
    Semin Cell Dev Biol 19:444-51. 2008
    ..This review will discuss each of these steps with particular emphasis on the communication pathways between each cell type involved and the roles of ephrins, sclerostin, RANKL and PTHrP...
  91. ncbi Primary hyperparathyroidism and the skeleton
    Leif Mosekilde
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, DK 8000, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 69:1-19. 2008
    ..In symptomatic hypercalcaemic PHPT with low BMD where curative surgery is impossible or contraindicated a combination of a calcimimetic and a bisphosphonate may be an undocumented therapeutical option that needs further evaluation...
  92. ncbi CLINICAL Review #: the role of receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/osteoprotegerin: clinical implications
    Damaris Vega
    Department of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 92:4514-21. 2007
    Receptor activator of nuclear factor-kappaB ligand (RANKL), receptor activator of nuclear factor-kappaB (RANK), and osteoprotegerin (OPG) play a central role in bone remodeling and disorders of mineral metabolism.
  93. pmc Osteoimmunology: interactions of the bone and immune system
    Joseph Lorenzo
    Department of Medicine, The University of Connecticut Health Center, N4054, MC5456, 263 Farmington Avenue, Farmington, Connecticut 06030 5456, USA
    Endocr Rev 29:403-40. 2008
    ..It is hoped that an appreciation of the interactions of these two organ systems will lead to better therapeutics for diseases that affect either or both...
  94. pmc The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice
    Daniel A Rauch
    Division of Molecular Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e15755. 2010
    ..Here we provide evidence that ARF is a master regulator of bone remodeling and osteosarcoma (OS) development in mice...
  95. pmc Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues
    Kathryn M Thrailkill
    Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, 800 Marshall St, Springer Bldg, Mail Slot 512 6, Little Rock, AR 72202, USA
    Am J Physiol Endocrinol Metab 289:E735-45. 2005
    ..In so doing, we present evidence that insulin, acting as an anabolic agent in bone, can preserve and increase bone density and bone strength, presumably through direct and/or indirect effects on bone formation...
  96. ncbi Differential effects of androgens and estrogens on bone turnover in normal men
    Benjamin Z Leder
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:204-10. 2003
    ..These data also suggest that androgens may play an important role in the regulation of bone formation in men...
  97. ncbi Osteoarthritis cartilage histopathology: grading and staging
    K P H Pritzker
    Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Osteoarthritis Cartilage 14:13-29. 2006
    ..Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method...
  98. ncbi Teriparatide or alendronate in glucocorticoid-induced osteoporosis
    Kenneth G Saag
    University of Alabama at Birmingham, Birmingham 35294 3408, USA
    N Engl J Med 357:2028-39. 2007
    ..Studies of anabolic therapy in patients who are receiving long-term glucocorticoids and are at high risk for fracture are lacking...
  99. ncbi Periosteal bone formation--a neglected determinant of bone strength
    Ego Seeman
    Austin Hospital, University of Melbourne, Melbourne, Australia
    N Engl J Med 349:320-3. 2003
  100. ncbi RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta
    Hiroshi Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 416:744-9. 2002
    ..Our study places the IFN-beta system in a new context, and may offer a molecular basis for the treatment of bone diseases...
  101. ncbi Osteoporosis
    Philip Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney 2065, NSW, Australia
    Lancet 367:2010-8. 2006
    ..At the same time, other diagnostic and therapeutic approaches, including biological agents, are likely to become more widespread...

Research Grants71

  1. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    This project investigates osteoclast (OC) biology, and mechanisms of normal and pathological bone remodeling under 2 Specific Aims. SA 1 will continue our investigations of a novel osteopetrosis gene we discovered called Plekhm1...
  2. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2013
    ..VEGF is also critical for normal bone remodeling. Zoledronic acid, by improving both bone remodeling and VEGF expression in bone and vasculature, may correct ..
  3. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..resonance (NMR) to determine bone quality;analyze bone formation and bone resorption activities to determine bone remodeling status;analyze material testing of femur and biomechanical tests of vertebrae to determine bone strength and ..
  4. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..Recent evidence from rodents and humans suggest a major role for serotonin in regulation of bone remodeling, and bone cells express receptors (including serotonin receptors) that could be affected by SGAs...
  5. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..In sum, we will determine the role of the CNS in regulating bone remodeling and determine how age-related changes in BAT may impact bone mass...
  6. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bone remodeling is a sequence of events in which osteoclastic resorption is coupled to osteoblast-driven formation...
  7. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A tight balance of bone formation and bone resorption (termed as the bone remodeling) maintains the homeostasis of the skeleton...
  8. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    ..are also reported to have positive effects on pancreatic b-cell function, cardiovascular performance and bone remodeling. The metabolic benefits of GH replacement in GHD patients has fueled the off-label use and abuse of GH in ..
  9. VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..increases in aBMD at the spine, hip, forearm and total body, as assessed by DXA and (b) improve balance of bone remodeling through decreases in bone turnover;Aim 2: High-dose vitamin D3 will improve: vBMD and bone structure and ..
  10. Endothelin-1 and androgen in prostate cancer bone metastasis and bone health
    Gregory A Clines; Fiscal Year: 2013
    ..risk, a complementary preclinical study will examine the effects of combined ADT and zibotentan on normal bone remodeling and strength of bone unaffected by prostate cancer...
  11. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2013
    ..Regardless of the etiology, osteoporosis is characterized by an imbalance in bone remodeling, such that osteoclastic bone resorption exceeds osteoblastic bone formation, which leads to low bone mass...
  12. cGMP-dependent Protein Kinase Function in Osteoblast Mechanotransduction
    Renate B Pilz; Fiscal Year: 2013
    ..down-stream signaling proteins in mechanically-stimulated osteoblasts and determine the role of PKG II in bone remodeling in genetically-modified mice...
  13. Purinergic Regulation of Bone Metabolism
    Bruce Neil Cronstein; Fiscal Year: 2013
    ..In the first aim we will examine the role of adenosine and adenosine A1 receptors in osteoclast function and bone remodeling and confirm and expand on our preliminary studies...
  14. Pharmacology of Risperidone Effects on Bone Remodeling and Energy Metabolism
    Karen L Houseknecht; Fiscal Year: 2013
    ..adverse side effect occurs via multiple mechanisms: 1) by directly interacting with bone cells and uncoupling bone remodeling;[2) via hyper-prolactinemia induced hypogonadism] and 3) by modulating the sympathetic nervous system output ..
  15. FUNCTION AND REGULATION OF OSTEONECTIN IN BONE
    Anne M Delany; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bone loss with aging results from imbalanced bone remodeling, with decreased osteoblast number, increased osteoclast number, and increased adipocyte number in the marrow...
  16. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..Osteoclasts (OCLs) are the only bone-resorbing cells that are essential for normal skeletal development and bone remodeling throughout life...
  17. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2012
    ..Regardless of the etiology, osteoporosis is characterized by an imbalance in bone remodeling, such that osteoclastic bone resorption exceeds osteoblastic bone formation, which leads to low bone mass or ..
  18. WNT and gonadotropin mediated regulation of ovarian steroidogenesis
    JENNIFER HERNANDEZ GIFFORD; Fiscal Year: 2010
    ..levels influence numerous physiological and pathological processes including fertility and sexual behavior, bone remodeling and the development of various endocrine cancers...
  19. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..large bones and to develop therapeutics to treat overall bone loss, very little information is available on bone remodeling in the human craniofacial skeleton, nor the mechanisms involved in osteonecrosis of the jaw and there are few ..
  20. Effect of MIP-1 delta on Osteoclast Development and Pathological Bone Resorption
    Scott L Kominsky; Fiscal Year: 2010
    b>Bone remodeling is a continuously occurring balance of bone destruction followed by bone formation, which maintains bone strength by replacing damaged bone with new bone...
  21. Correlating and Quantifying Mechanically-induced Bone Cell Microdamage
    Marnie M Saunders; Fiscal Year: 2012
    ..the currently purported theory that mechanical damage is sensed by the osteocyte which then coordinates bone remodeling activity is tested...
  22. Non-Classical Manifestations of Primary Hyperparathyroidism
    Shonni J Silverberg; Fiscal Year: 2013
    ..the early effects of vitamin D repletion in PHPT on static and dynamic histomorphometric parameters of bone remodeling (by quadruple labeled bone biopsy). Theme 2. Cardiovascular manifestations of PHPT: SA2a...
  23. Connexin 43 in Bone Remodeling
    Roberto Civitelli; Fiscal Year: 2013
    ..Results will establish the mechanisms by which Cx43 modulates cortical bone and how such mechanisms cause the skeletal abnormalities of ODDD, findings that may be translated to clinical settings and lead to pharmacologic targeting. ..
  24. THE TEMPORAL AND SPATIAL REGULATION OF BONE ACQUISITION BY SERUM IGF-1
    Shoshana Yakar; Fiscal Year: 2012
    ..Several lines of evidence support the tenet that IGF-I has an important role in the process of bone remodeling. Human studies have demonstrated a relatively strong correlation between serum IGF-I and bone mineral density ..
  25. Relationship between Hdac3 suppression and Wnt signaling in osteoblasts
    Meghan McGee-Lawrence; Fiscal Year: 2011
    ..bone loss may be due to disregulation of Wnt/[unreadable]-catenin signaling, a key regulatory pathway for bone remodeling. Importantly, levels of Axin2 (a negative feedback inhibitor of Wnt signaling) are increased in Hdac3-CKO ..
  26. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen T Bishop; Fiscal Year: 2012
    ..points by quantifying capillary density with microangiography and bone blood flow by hydrogen washout;while bone remodeling is determined after fluorochrome labeling by quantitative histomorphometry...
  27. Phosphorylation of PTH1R by TGF-betaRII in Bone Remodeling
    Tao Qiu; Fiscal Year: 2013
    ..models are designed to confirm the hypothesis that phosphorylation of PTH1R by T2RII integrates signaling of bone remodeling. Specific Aims to accomplish this are: Specific Aim 1: Determine the function of targeted phosphorylation of ..
  28. CSF-1 GENE EXPRESSION IN OSTEOCLAST BIOLOGY
    SHERRY L ABBOUD-WERNER; Fiscal Year: 2013
    ..are key determinants of oxidant stress that impact osteocyte survival/function that is essential for bone remodeling. The long-term goal of this proposal is to delineate mechanistic pathways by which CSF-1/oxidative stress ..
  29. Optimizing Normal Collagen Replacement in Osteogenesis Imperfecta
    Sarah L Dallas; Fiscal Year: 2013
    ..However, recent concerns over the potential of these drugs to inhibit bone remodeling and impair fracture healing, as well as the lack of knowledge about the long term consequences of ..
  30. Evaluating the role of Thrombospondin-1-CD47 mediated nitric oxide signaling in t
    Sarah Amend; Fiscal Year: 2013
    ..We propose to evaluate TSP1-mediated NO signaling in bone remodeling, both in healthy and bone metastatic states...
  31. AgRP neurons regulate bone remodeling in aging
    KARL LEONARD INSOGNA; Fiscal Year: 2013
    ..2008), we also predict that increasing ROS exposure of the melanocortin system during aging is a critical contributor to aging-associated bone loss and the pathogenesis of osteoporosis. ..
  32. Structural microenvironment of bone marrow stem cells
    FRANCESCO B RAMIREZ; Fiscal Year: 2013
    ..We previously demonstrated that osteopenia in MFS mice reflects perturbed bone remodeling due to impaired calibration of local anabolic and catabolic signals...
  33. Drug-eluting Stapes Prosthesis for the Prevention of Sensorineural Hearing Loss
    Michael J McKenna; Fiscal Year: 2013
    ..The otic capsule is unique in that it normally exhibits little or no bone remodeling. Otosclerosis is characterized by an abnormal remodeling of the otic capsule...
  34. The Mechanistic Control of Bone Matrix Material Properties by TGF-beta and Runx2
    TAMARA N ALLISTON; Fiscal Year: 2013
    ..modify matrix material properties directly, or indirectly by cooperating with osteoclasts to change bone remodeling activity remains unclear...
  35. Genetic Control of Osteoblast Differentiation
    Benoit de Crombrugghe; Fiscal Year: 2012
    ..provide considerable new insights in the mechanisms of bone formation by Osx in the homeostatic control of bone remodeling. PUBLIC HEALTH RELEVANCE: Understanding the mechanisms by which bone formation is controlled, is of critical ..
  36. Regulation of osteoclast biology by anion exchanger SLC4A2 in mouse and human sys
    Antonios O Aliprantis; Fiscal Year: 2013
    ..Pathologic inequality in bone remodeling favoring resorption over formation leads to diseases such as osteoporosis, rheumatoid arthritis and ..
  37. Functional Interactions between Cancer Cells and Sensory Neurons
    DONALD SIMONE; Fiscal Year: 2012
    ..The mechanisms that drive cancer pain are multi-factorial and include bone remodeling, inflammatory responses, neurodegeneration, and release of algesic substances from the cancer cells that ..
  38. BMP-2 Regulation of Bone Homeostasis
    Vicki Rosen; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Bone remodeling occurs throughout adult life, and requires that osteoblasts (bone forming cells) and osteoclasts (bone ..
  39. PDGF D AND PROSTATE CANCER BONE METASTASIS
    Hyeong Reh Choi Kim; Fiscal Year: 2013
    ..this project is to investigate the molecular mechanisms by which prostate carcinoma-produced PDGF initiates bone remodeling, a critical event for tumor cell colonization to the bone...
  40. Assessing and modifying bone quality in chronic kidney disease
    Chris Newman; Fiscal Year: 2013
    ..25-week-old animals will be treated for 5 weeks (equivalent to one bone remodeling cycle)...
  41. Pathophysiologic mechanisms of biosphosphonate related osteonecrosis of the jaws
    Sotirios Tetradis; Fiscal Year: 2012
    ..the mechanisms by which the oral environment is sensitive to oxidative stress and BP inhibition of bone remodeling may lead to novel therapeutic approaches to reduce BRONJ frequency, progression, and severity...
  42. Role of Twisted Gastrulation in Osteoclastogenesis
    Rajaram Gopalakrishnan; Fiscal Year: 2013
    ..BMPs are potent inducers of bone formation and any dysregulation of BMP signaling can lead to defects in bone remodeling. To examine whether Twsg1 regulates bone remodeling, we generated a Twsg1-null mouse that showed profound ..
  43. Role of TGIF in Wnt-Induced Bone Formation
    Azeddine Atfi; Fiscal Year: 2013
    ..A master regulator of bone remodeling is the canonical Wnt signaling pathway, which exerts a tight control over several aspects of osteoblast ..
  44. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    ..nerve fibers using capsaicin or guanethidine will allow us to determine whether these nerve fibers regulate bone remodeling/repair/healing and fracture-induced bone pain...
  45. Proteoglycan-4:A novel protein regulating skeletal actions of parathyroid hormone
    CHAD MICHAEL NOVINCE; Fiscal Year: 2010
    ..The role of prg4 as a mediator of bone remodeling and PTH anabolism is unknown with preliminary data from the project laboratory supporting its role in ..
  46. ACR Basic Research Conference
    Bruce Neil Cronstein; Fiscal Year: 2013
    ..Topics have been chosen for the four subsequent conferences: 2011 will focus on regulation of bone remodeling, bone pathology is a common facet of many rheumatic diseases and occurs as a consequence of many treatments...
  47. Effect of HIV Infection and HAART on Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2013
    ..The skeleton continually regenerates through homeostatic bone remodeling, a process involving the removal of worn bone and reformation of new bone...
  48. Bone Turnover Effects on Bisphosphonate Concentration in the Mandible
    Kenneth M Kozloff; Fiscal Year: 2012
    ..This may interfere with bone remodeling required following tooth removal- typically a preceding event in ONJ...
  49. INTEGRIN SIGNALING PATHWAYS IN PROSTATE CANCER
    LUCIA LANGUINO; Fiscal Year: 2009
    ..integrin, [unreadable]v[unreadable]3, is induced by Runx2, a transcription factor known to mediate bone remodeling. In a parallel series of experiments, we have also found that [unreadable]v[unreadable]6 promotes tumor-..
  50. Osteocalcin: the hormonal link between bone and reproduction
    Gerard Karsenty; Fiscal Year: 2013
    ..another phenotype in the Osteocalcin-deficient mice that may allow us to establish an endocrine link between bone remodeling and reproduction...
  51. Defining and demystifying bone quality in type 2 diabetes mellitus
    KENDALL MOSELEY; Fiscal Year: 2013
    ..3) To analyze differences in parameters of active bone remodeling in NGT, IGT and T2DM...
  52. Modulation of Muscle Regenerationby Growth Factors
    Elisabeth R Barton; Fiscal Year: 2013
    ..In other tissue types, MMP-13 activity is a key regulator of wound healing, bone remodeling, and tumor invasion, as well as a modulator of additional MMP activity...
  53. Mechanism of Mitochondrial Dysfunction in Mesenchymal Stem Cells During Aging
    Roman Eliseev; Fiscal Year: 2013
    ..Eliseev into research areas that are new to him, such as stem cells, bone remodeling and repair, aging, osteoporosis, and mouse genetic models...
  54. Amyloid-RAGE Signaling in Bone Remodeling
    Wen Cheng Xiong; Fiscal Year: 2013
    ..However, the function of APP and/or A2 in bone remodeling remains largely unclear, which is a major focus of our study...
  55. Mechanism of ITAM Signal Regulation in Osteoclasts
    Mary Beth Humphrey; Fiscal Year: 2012
    ..b>Bone remodeling occurs throughout life and imbalances in formation and resorption lead to human diseases including ..
  56. MECHANICAL LOADING AND BONE
    Hiroki Yokota; Fiscal Year: 2013
    ..Many lines of evidence in animal studies support enhancement of bone remodeling with strain of 1000 - 2000 microstrains...
  57. Regulation of Osteoclastogenesis and Arthritic Bone Resorption by RBP-J
    Baohong Zhao; Fiscal Year: 2013
    ..osteoclastogenesis and bone resorption in vitro and in vivo but has minimal effects on physiological bone remodeling. This indicates that RBP-J is a key negative regulator of inflammatory/pathologic bone resorption and thus an ..
  58. Osteopontin and Collateral Vessel Growth
    WILLIAM ROBERT TAYLOR; Fiscal Year: 2012
    ..The secreted phosphoprotein osteopontin, well known as a modulator of bone remodeling, is being considered in the present study for its potential role in reparative angiogenesis...
  59. Function and Behavior Phenotype of Inflammatory Arthritis in the Rat Knee and TMJ
    Kyle D Allen; Fiscal Year: 2013
    ..processes occurring over years, and while end-stage disease can be described by cartilage loss, subchondral bone remodeling, dysfunction, and pain, the initiating stages do not always have a clear etiology...
  60. Shp2 in Osteoclastogenesis and Bone Remodeling
    Wentian Yang; Fiscal Year: 2010
    ..the function of protein tyrosine phosphatases (PTP), specifically PTP Shp2, in osteoclastogenesis and bone remodeling. Taking a tissue/cell specific gene knockout approach, I bred Shp2 floxed allele with LysM-Cre and Ctsk-Cre ..
  61. Regulation of (Ca2+)i oscillation and osteoclast differentiation by RGS12
    Shuying Yang; Fiscal Year: 2010
    ..Aim 3. To define the role and mechanism of RGS12 in vivo in bone remodeling by osteoclast-specific targeted disruption of the RGS12 gene using Cre/loxP technology!
  62. Effect of Osteoporosis on Spine Fusion
    BRIAN CROCKETT COOLEY; Fiscal Year: 2010
    ..Future directions will include an in-depth investigation of the mechanistic aspects of fusion site bone remodeling under various conditions of osteoporosis, as well as investigations of therapeutic options for osteoporosis ..
  63. VITAMIN D HORMONE MECHANISM OF ACTION IN CULTURED CELLS
    MARK HAUSSLER; Fiscal Year: 1999
    ..bone cells and epithelial cells of the intestine, where vitamin D exerts its major effects upon bone remodeling and mineral absorption, respectively...
  64. MRI-BASED VIRTUAL BONE BIOPSY IN RENAL OSTEODYSTROPHY
    Felix Wehrli; Fiscal Year: 2001
    DESCRIPTION (Taken from the application): Renal osteodystrophy (ROD) is a multifactorial disorder of bone remodeling, resulting in skeletal deformities and fractures...
  65. Viscoelastic deformation of bone matrix in postmenopause
    Do Gyoon Kim; Fiscal Year: 2010
    ..For the vertebrae that are weakened by postmenopausal active bone remodeling, these cumulative daily loads are more susceptible to vertebral fractures resulting in progressive vertebral ..
  66. Novel therapy for osteoporosis
    Emma Moore; Fiscal Year: 2009
    ..Post-menopausal osteoporosis is characterized by an increased rate of bone remodeling;however, bone formation does not keep pace with increased bone resorption resulting in net loss of bone...
  67. Bone Tissue Engineerig: Effect of Dynamic Perfusion
    Aaron Goldstein; Fiscal Year: 2009
    ..of a bioactive material that is capable of stimulating vascular infiltration, tissue integration, and normal bone remodeling. To date, engineered tissues consisting of progenitor cells cultured within porous scaffolds have not been as ..
  68. CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERS
    Philip Osdoby; Fiscal Year: 2002
    ..is just beginning to emerge that osteoclasts themselves synthesize and release factors that may influence bone remodeling. We therefore hypothesize that osteoclast-derived signals may function as autocrine effectors of osteoclast ..
  69. NEUROTRANSMITTERS AND CYTOKINES IN TOOTH MOVEMENT
    ZEEV DAVIDOVITCH; Fiscal Year: 1992
    ..and tumor necrosis factor-alpha; 2) assess the effects of each of these agents on an in vitro bone remodeling test system; 3) investigate whether these agents bind to target cells in the PDL upon local administration in ..
  70. Role of Musculo-Dynamics in Bone Fluid Flow, Circulation and Adaptation
    Yi Xian Qin; Fiscal Year: 2009
    ..While bone remodeling was demonstrated to be sensitive to high rate of dynamic physiological stimulation, the role of fluid flow in ..
  71. BONE MARROW TRANSPLANTATION IN OIM--A GENE THERAPY MODEL
    DANIEL MC BRIDE; Fiscal Year: 2001
    Bone formation occurs during embryonic development, somatic growth, and during bone remodeling and repair...