regeneration

Summary

Top Publications

  1. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
  2. pmc Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states
    Ronald D Cohn
    McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland 21205, USA
    Nat Med 13:204-10. 2007
  3. doi Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    Toshiro Sato
    Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 459:262-5. 2009
  4. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
  5. pmc The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
    Bin Zhao
    Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China
    Nat Cell Biol 13:877-83. 2011
  6. ncbi Cellular and molecular regulation of muscle regeneration
    Sophie B P Chargé
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Physiol Rev 84:209-38. 2004
  7. doi Collective cell migration in morphogenesis, regeneration and cancer
    Peter Friedl
    Microscopical Imaging of the Cell, Department of Cell Biology 283, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Mol Cell Biol 10:445-57. 2009
  8. ncbi Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
  9. pmc Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture
    P M Gilbert
    Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 329:1078-81. 2010
  10. pmc Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration
    Daniel E Wagner
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology MIT, Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 332:811-6. 2011

Detail Information

Publications411 found, 100 shown here

  1. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..is mainly composed of terminally differentiated cells, but is not a terminally differentiated organ because it contains stem cells supporting its regeneration. The existence of these cells opens new opportunities for myocardial repair.
  2. pmc Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states
    Ronald D Cohn
    McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland 21205, USA
    Nat Med 13:204-10. 2007
    ..Here we show that increased TGF-beta activity leads to failed muscle regeneration in fibrillin-1-deficient mice...
  3. doi Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    Toshiro Sato
    Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 459:262-5. 2009
    ..We conclude that intestinal cryptvillus units are self-organizing structures, which can be built from a single stem cell in the absence of a non-epithelial cellular niche...
  4. ncbi Wound healing--aiming for perfect skin regeneration
    P Martin
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 276:75-81. 1997
    ..these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.
  5. pmc The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
    Bin Zhao
    Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China
    Nat Cell Biol 13:877-83. 2011
    Precise control of organ size is crucial during animal development and regeneration. In Drosophila and mammals, studies over the past decade have uncovered a critical role for the Hippo tumour-suppressor pathway in the regulation of organ ..
  6. ncbi Cellular and molecular regulation of muscle regeneration
    Sophie B P Chargé
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Physiol Rev 84:209-38. 2004
    ..In addition, recent evidence supports the possible contribution of adult stem cells in the muscle regeneration process...
  7. doi Collective cell migration in morphogenesis, regeneration and cancer
    Peter Friedl
    Microscopical Imaging of the Cell, Department of Cell Biology 283, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Mol Cell Biol 10:445-57. 2009
    ..Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research...
  8. ncbi Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
    ..Our data establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs...
  9. pmc Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture
    P M Gilbert
    Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 329:1078-81. 2010
    ..that mimic the elasticity of muscle (12 kilopascals) self-renew in vitro and contribute extensively to muscle regeneration when subsequently transplanted into mice and assayed histologically and quantitatively by noninvasive ..
  10. pmc Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration
    Daniel E Wagner
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology MIT, Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 332:811-6. 2011
    ..Whether regeneration is accomplished by pluripotent cells or by the collective activity of multiple lineage-restricted cell types is ..
  11. pmc Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    Fabrizio Thorel
    Department of Cell Physiology and Metabolism, University of Geneva Faculty of Medicine, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Nature 464:1149-54. 2010
    ..Here we show beta-cell regeneration in a transgenic model of diphtheria-toxin-induced acute selective near-total beta-cell ablation...
  12. pmc Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
    Baozhi Chen
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Chem Biol 5:100-7. 2009
    ..The signal transduction mechanisms shown here to be chemically tractable additionally contribute to Wnt-independent signal transduction pathways and thus could be broadly exploited for chemical genetics and therapeutic goals...
  13. pmc Telocytes in human skin--are they involved in skin regeneration?
    Laura Ceafalan
    Molecular Medicine Laboratory, V Babeş National Institute of Pathology, Bucharest, Romania
    J Cell Mol Med 16:1405-20. 2012
    ..In conclusion, based on TC distribution and intercellular connections, our results suggested that TCs might be involved in skin homeostasis, skin remodelling, skin regeneration and skin repair.
  14. ncbi Investigation of multipotent postnatal stem cells from human periodontal ligament
    Byoung Moo Seo
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Lancet 364:149-55. 2004
    ..We investigated the notion that human PDL contains stem cells that could be used to regenerate periodontal tissue...
  15. ncbi Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche
    Charlotte A Collins
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Cell 122:289-301. 2005
    ..into radiation-ablated muscles and demonstrate that satellite cells are self-sufficient as a source of regeneration. As few as seven satellite cells associated with one transplanted myofiber can generate over 100 new myofibers ..
  16. ncbi Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
    Under conditions of tissue injury, myocardial replication and regeneration have been reported...
  17. doi Functional screening identifies miRNAs inducing cardiac regeneration
    Ana Eulalio
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy
    Nature 492:376-81. 2012
    ..of the minimal renewal of cardiomyocytes during adult life, repair of cardiac damage through myocardial regeneration is very limited...
  18. pmc Generation and regeneration of cells of the liver and pancreas
    Kenneth S Zaret
    Epigenetics and Progenitor Cells Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Science 322:1490-4. 2008
    ..Interest in the development and regeneration of the organs has been fueled by the intense need for hepatocytes and pancreatic beta cells in the therapeutic ..
  19. pmc Advances in understanding tissue regenerative capacity and mechanisms in animals
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Nat Rev Genet 11:710-22. 2010
    Questions about how and why tissue regeneration occurs have captured the attention of countless biologists, biomedical engineers and clinicians...
  20. doi Wound repair and regeneration
    Geoffrey C Gurtner
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 257 Campus Drive, Stanford, California 94305 5148, USA
    Nature 453:314-21. 2008
    ..in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life...
  21. pmc Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea
    George T Eisenhoffer
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell Stem Cell 3:327-39. 2008
    ..only the ability to measure and study the in vivo population dynamics of adult stem cells during tissue homeostasis and regeneration, but also the utility of studies in planarians to broadly inform stem cell biology in adult organisms.
  22. ncbi Notch-mediated restoration of regenerative potential to aged muscle
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5235, USA
    Science 302:1575-7. 2003
    ..cells) had a markedly impaired propensity to proliferate and to produce myoblasts necessary for muscle regeneration. This was due to insufficient up-regulation of the Notch ligand Delta and, thus, diminished activation of Notch ..
  23. ncbi Direct isolation of satellite cells for skeletal muscle regeneration
    Didier Montarras
    CNRS Unité de Recherche Associée 2578, Department of Developmental Biology, INSERM, Pasteur Institute, 75724 Paris Cedex 15, France
    Science 309:2064-7. 2005
    Muscle satellite cells contribute to muscle regeneration. We have used a Pax3(GFP/+) mouse line to directly isolate (Pax3)(green fluorescent protein)-expressing muscle satellite cells, by flow cytometry from adult skeletal muscles, as a ..
  24. pmc Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice
    Katrin Arnold
    Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, MA 02138, USA
    Cell Stem Cell 9:317-29. 2011
    ..Thus, our results identify Sox2 expression in numerous adult endodermal and ectodermal stem cell compartments, which are critical for normal tissue regeneration and survival.
  25. ncbi p16INK4a induces an age-dependent decline in islet regenerative potential
    Janakiraman Krishnamurthy
    Department of Medicine, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Nature 443:453-7. 2006
    ..Here we show that p16INK4a constrains islet proliferation and regeneration in an age-dependent manner...
  26. ncbi Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
    Shahin Rafii
    Department of Hematology Oncology and Genetic Medicine, Cornell University Medical College, New York, New York, 10021 USA
    Nat Med 9:702-12. 2003
    ..cells to specific organs, will open up new avenues of research to accelerate organ vascularization and regeneration. In addition, identification of factors that promote differentiation of the progenitor cells will permit ..
  27. pmc Human cardiac stem cells
    Claudia Bearzi
    Department of Medicine, Cardiovascular Research Institute, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 104:14068-73. 2007
    ..Thus, hCSCs can be isolated and expanded in vitro for subsequent autologous regeneration of dead myocardium in patients affected by heart failure of ischemic and nonischemic origin.
  28. pmc Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells
    J R Beauchamp
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, W12 ONN United Kingdom
    J Cell Biol 151:1221-34. 2000
    ..We conclude that the expression of CD34, Myf5, and M-cadherin defines quiescent, committed precursors and speculate that the CD34(-ve), Myf5(-ve) minority may be involved in maintaining the lineage-committed majority...
  29. doi Niche regulation of muscle satellite cell self-renewal and differentiation
    Shihuan Kuang
    The Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Cell Stem Cell 2:22-31. 2008
    ..A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases...
  30. ncbi Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 362:697-703. 2003
    Myocardial regeneration via stem-cell mobilisation at the time of myocardial infarction is known to occur, although the mechanism for stem-cell homing to infarcted tissue subsequently and whether this approach can be used for treatment of ..
  31. doi Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, 25 rue du Dr Roux, Paris, F 75015, France
    Development 138:3647-56. 2011
    ..This localised loss of satellite cells was not compensated for endogenously by other cell types, but muscle regeneration was rescued after transplantation of adult Pax7(+) satellite cells alone...
  32. pmc Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    Wolfram Goessling
    Harvard Stem Cell Institute, Cambridge, MA 02138, USA
    Cell 136:1136-47. 2009
    ..The relationship between PGE2 and Wnt was also conserved during regeneration of other organ systems...
  33. ncbi Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    Ryota Uemura
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Circ Res 98:1414-21. 2006
    ..Preconditioning of BMSCs enhanced their survival and ability to attenuate LV remodeling, which was attributable, in part, to paracrine effects...
  34. pmc Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
    Luciano C Amado
    Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:11474-9. 2005
    ....
  35. pmc A regulatory program for excretory system regeneration in planarians
    M Lucila Scimone
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Development 138:4387-98. 2011
    ..Eya and Sall, that encode transcription regulatory proteins that are required for planarian protonephridia regeneration. During regeneration, planarian stem cells are induced to form a cell population in regeneration blastemas ..
  36. pmc Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation
    Yoshinori Sumita
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Int J Biochem Cell Biol 43:80-7. 2011
    ..We propose here that cell therapy using BMDCs can rescue the functional damage of irradiated SGs by direct differentiation of donor BMDCs into salivary epithelial cells...
  37. pmc Adenosine signaling promotes regeneration of pancreatic β cells in vivo
    Olov Andersson
    Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology and Program in Genetics and Human Genetics, Diabetes Center, Institute for Regeneration Medicine and Liver Center, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Cell Metab 15:885-94. 2012
    ..Using a zebrafish model of diabetes, we screened ~7,000 small molecules to identify enhancers of β cell regeneration. The compounds we identified converge on the adenosine signaling pathway and include exogenous agonists and ..
  38. pmc Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart
    Konstantinos Malliaras
    Cedars Sinai Heart Institute, Los Angeles, CA, USA
    EMBO Mol Med 5:191-209. 2013
    ..Thus, CDCs induce myocardial regeneration by differentially upregulating two mechanisms of endogenous cell proliferation.
  39. pmc Transient regenerative potential of the neonatal mouse heart
    Enzo R Porrello
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 331:1078-80. 2011
    Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart...
  40. pmc Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells
    Francesco Saverio Tedesco
    Division of Regenerative Medicine, San Raffaele Scientific Institute, 58 Via Olgettina, Milan, Italy
    J Clin Invest 120:11-9. 2010
    ..b>Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle ..
  41. ncbi Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
    Birgit Assmus
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 106:3009-17. 2002
    ..The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown...
  42. ncbi Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
    A Musaro
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts, USA
    Nat Genet 27:195-200. 2001
    ..The preservation of muscle architecture and age-independent regenerative capacity through localized mIgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty...
  43. pmc Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes
    Kazu Kikuchi
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 464:601-5. 2010
    ..Yet, there is little or no significant cardiac muscle regeneration after an injury such as acute myocardial infarction...
  44. ncbi Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair
    Caroline Schmidt-Lucke
    Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Circulation 111:2981-7. 2005
    ..Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium...
  45. pmc Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    Huaqi Jiang
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cell 137:1343-55. 2009
    ..Hence, cytokine-mediated feedback enables stem cells to replace spent progeny as they are lost, thereby establishing gut homeostasis...
  46. pmc Heart regeneration
    Michael A Laflamme
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
    Nature 473:326-35. 2011
    ..Heart regeneration is well documented in amphibia and fish and in developing mammals...
  47. ncbi SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells
    Peter W Reddien
    Howard Hughes Medical Institute, Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Science 310:1327-30. 2005
    ..RNA interference (RNAi) of smedwi-2 blocks regeneration, even though neoblasts are present, irradiation-sensitive, and capable of proliferating in response to wounding;..
  48. pmc Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells
    Fabien Le Grand
    Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Regenerative Medicine Program, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Cell Stem Cell 4:535-47. 2009
    ..satellite stem cells expressed the Wnt receptor Fzd7 and that its candidate ligand Wnt7a was upregulated during regeneration. Wnt7a markedly stimulated the symmetric expansion of satellite stem cells but did not affect the growth or ..
  49. pmc Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
    Konstantinos E Hatzistergos
    University of Miami Miller School of Medicine, Interdisciplinary Stem Cell Institute, Miami, FL 33136, USA
    Circ Res 107:913-22. 2010
    ..Bone marrow-derived mesenchymal stem cells (MSCs) have the capacity for cardiac repair that appears to exceed their capacity for differentiation into cardiac myocytes...
  50. pmc Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
    Chris Jopling
    Center of Regenerative Medicine in Barcelona, Spain
    Nature 464:606-9. 2010
    ..To address directly the source of newly formed cardiomyocytes during zebrafish heart regeneration, we first established a genetic strategy to trace the lineage of cardiomyocytes in the adult fish, on the basis ..
  51. ncbi Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
    Andrew S Brack
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 317:807-10. 2007
    ..These results indicate that the Wnt signaling pathway may play a critical role in tissue-specific stem cell aging and an increase in tissue fibrosis with age...
  52. pmc Bioelectric signaling regulates head and organ size during planarian regeneration
    Wendy Scott Beane
    Biology Department and Tufts Center for Regenerative and Developmental Biology, Tufts University, 200 Boston Avenue, Suite 4600, Medford, MA 02155, USA
    Development 140:313-22. 2013
    ..report that membrane voltage-dependent bioelectric signaling determines both head size and organ scaling during regeneration. RNA interference of the H(+),K(+)-ATPase ion pump results in membrane hyperpolarization, which has no effect ..
  53. pmc In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
    Meritxell Huch
    Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Netherlands
    Nature 494:247-50. 2013
    ..These findings indicate that previous observations concerning Lgr5(+) stem cells in actively self-renewing tissues can also be extended to damage-induced stem cells in a tissue with a low rate of spontaneous proliferation...
  54. pmc The cellular basis for animal regeneration
    Elly M Tanaka
    Technical University of Dresden, DFG Center for Regenerative Therapies Dresden, c o Max Planck Institute of Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden, Germany
    Dev Cell 21:172-85. 2011
    ..advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl...
  55. pmc TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration
    Daniela Palacios
    Dulbecco Telethon Institute DTI, IRCCS Fondazione Santa Lucia and European Brain Research Institute, 00143 Roma, Italy
    Cell Stem Cell 7:455-69. 2010
    How regeneration cues are converted into the epigenetic information that controls gene expression in adult stem cells is currently unknown...
  56. pmc Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration
    Piul Rabbani
    Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    Cell 145:941-55. 2011
    ..EpSCs and McSCs coordinately activate Wnt signaling at the onset of hair follicle regeneration within the sHG...
  57. ncbi The skeletal muscle satellite cell: the stem cell that came in from the cold
    Peter S Zammit
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL England
    J Histochem Cytochem 54:1177-91. 2006
    ..This is a fast-moving and dynamic field, however, and in this review we discuss the evidence that we think puts this enigmatic cell firmly back at the center of adult myogenesis...
  58. pmc Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip
    Yuval Rinkevich
    Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305 5323, USA
    Nature 476:409-13. 2011
    The regrowth of amputated limbs and the distal tips of digits represent models of tissue regeneration in amphibians, fish and mice...
  59. pmc A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration
    Wendy S Beane
    Biology Department and Tufts Center for Regenerative and Developmental Biology, Tufts University, Medford, MA 02155 4243, USA
    Chem Biol 18:77-89. 2011
    ..genetics approach, we demonstrate that membrane voltage controls head-versus-tail identity during planarian regeneration. Our data suggest well-characterized drugs (already approved for human use) might be exploited to control adult ..
  60. pmc Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats
    Wan Chun Li
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 123:2792-802. 2010
    ..hypothesized that after partial pancreatectomy (Px) in adult rats, pancreatic-duct cells serve as a source of regeneration by undergoing a reproducible dedifferentiation and redifferentiation...
  61. pmc The head-regeneration transcriptome of the planarian Schmidtea mediterranea
    Thomas Sandmann
    Division Signaling and Functional Genomics, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Genome Biol 12:R76. 2011
    ..Despite the enormous potential of these animals for medical research and regenerative medicine, the mechanisms of regeneration and the molecules involved remain largely unknown.
  62. ncbi Inflammatory processes in muscle injury and repair
    James G Tidball
    Department of Physiological Science, 5833 Life Science Bldg, University of California, Los Angeles, CA 90095, USA
    Am J Physiol Regul Integr Comp Physiol 288:R345-53. 2005
    ..This inflammatory response coincides with muscle repair, regeneration, and growth, which involve activation and proliferation of satellite cells, followed by their terminal ..
  63. pmc microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7
    Jian Fu Chen
    McAllister Heart Institute, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 190:867-79. 2010
    Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite cell survival, self-renewal, and proliferation...
  64. doi Cells keep a memory of their tissue origin during axolotl limb regeneration
    Martin Kragl
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108
    Nature 460:60-5. 2009
    During limb regeneration adult tissue is converted into a zone of undifferentiated progenitors called the blastema that reforms the diverse tissues of the limb...
  65. pmc Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration
    Kathleen Kelly Tanaka
    MCD Biology, University of Colorado, Boulder, CO 80309, USA
    Cell Stem Cell 4:217-25. 2009
    ..cells, located between the basal lamina and plasma membrane of myofibers, are required for skeletal muscle regeneration. The capacity of satellite cells as well as other cell lineages including mesoangioblasts, mesenchymal stem ..
  66. ncbi Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration
    Hideki Iwaguro
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 105:732-8. 2002
    ..In the current study, we investigated the hypothesis that gene transfer can be used to achieve phenotypic modulation of EPCs...
  67. doi Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage
    Frederic Relaix
    UPMC Paris 06, UMR S 787, F 75013, Paris, France
    Development 139:2845-56. 2012
    ..accumulated over the years, until the link between satellite cells and the myoblasts that appear during muscle regeneration was finally established...
  68. doi Control of pancreatic β cell regeneration by glucose metabolism
    Shay Porat
    Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Cell Metab 13:440-9. 2011
    ..Physiologic β cell regeneration under stressed conditions relies on accelerated proliferation of surviving β cells, but the factors that ..
  69. ncbi Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    Sunil S Karhadkar
    Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 431:707-12. 2004
    ..of the Hedgehog (Hh) signalling pathway, which has essential roles in developmental patterning, is required for regeneration of prostate epithelium, and that continuous pathway activation transforms prostate progenitor cells and renders ..
  70. pmc The zebrafish as a model for complex tissue regeneration
    Matthew Gemberling
    Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Trends Genet 29:611-20. 2013
    For centuries, philosophers and scientists have been fascinated by the principles and implications of regeneration in lower vertebrate species...
  71. pmc Restoration of anterior regeneration in a planarian with limited regenerative ability
    James M Sikes
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Nature 500:77-80. 2013
    ..regenerative abilities, planarians have become important models for understanding the molecular basis of regeneration. However, planarian species with limited regenerative abilities are also found...
  72. doi PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, Ohio 44106 7080, USA
    J Orthop Res 29:1795-803. 2011
    With the identification of mesenchymal stem cells (MSCs) as pericytes, the details of bone formation, regeneration, and repair take on new meaning...
  73. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
    ..Rather, our results support a model in which the trachea, bronchioles, and alveoli are maintained by distinct populations of epithelial progenitor cells...
  74. pmc Metchnikoff's policemen: macrophages in development, homeostasis and regeneration
    James A Stefater
    Visual Systems Group, Divisions of Pediatric Ophthalmology and Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Trends Mol Med 17:743-52. 2011
    ..We also detail how modern genetic tools have facilitated new insights into these mysterious cells...
  75. doi ADAM17: a molecular switch to control inflammation and tissue regeneration
    Jürgen Scheller
    Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Trends Immunol 32:380-7. 2011
    ..Tissue-specific deletion, or hypomorphic knock-in, of Adam17 demonstrates an in vivo role for ADAM17 in controlling inflammation and tissue regeneration. The potential of ADAM17 as therapeutic target is also discussed.
  76. pmc Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
    K A Jackson
    Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 107:1395-402. 2001
    ..3%, primarily in small vessels adjacent to the infarct. Our results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction...
  77. doi Impact of ageing on muscle cell regeneration
    Silvia Carosio
    Institute Pasteur Cenci Bolognetti, Department of Histology and Medical Embryology, IIM, Sapienza University of Rome, Via A Scarpa, 14, Rome 00161, Italy
    Ageing Res Rev 10:35-42. 2011
    Skeletal muscle regeneration is a coordinate process in which several factors are sequentially activated to maintain and preserve muscle structure and function...
  78. doi Noggin and noggin-like genes control dorsoventral axis regeneration in planarians
    M Dolores Molina
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona and Institut de Biomedicina de Universitat de Barcelona, Avinguda Diagonal 645, Edifici annex, Planta 1, 08028 Barcelona, Catalunya, Spain
    Curr Biol 21:300-5. 2011
    ..Here we show that a BMP/ADMP organizer governs DV axis reestablishment during planarian regeneration, highlighting a greater-than-thought conservation of the mechanisms that establish this axis in protostomes and ..
  79. pmc microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice
    Ning Liu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 122:2054-65. 2012
    ..microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined...
  80. pmc Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA
    Lancet 379:895-904. 2012
    ..We aimed to assess safety of such an approach in patients with left ventricular dysfunction after myocardial infarction...
  81. doi Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia
    Simona Greco
    Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Milan, Italy
    FASEB J 23:3335-46. 2009
    ..to identify micro-RNAs (miRNAs) involved in the pathological pathways activated in skeletal muscle damage and regeneration by both dystrophin absence and acute ischemia...
  82. pmc Regeneration of glomerular podocytes by human renal progenitors
    Elisa Ronconi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
    J Am Soc Nephrol 20:322-32. 2009
    ..in a precise sequence within Bowman's capsule and exhibit heterogeneous potential for differentiation and regeneration. Cells localized to the urinary pole that expressed CD133 and CD24, but not podocyte markers (CD133+CD24+PDX- ..
  83. doi Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development
    Kathryn J Mitchell
    Myology Group, UMR S 787 INSERM, Universite Pierre et Marie Curie Paris VI, Paris, 75634, France
    Nat Cell Biol 12:257-66. 2010
    ..PW1(+)/Pax7(-) interstitial cells (PICs) are myogenic in vitro and efficiently contribute to skeletal muscle regeneration in vivo as well as generating satellite cells and PICs...
  84. pmc Evidence for human lung stem cells
    Jan Kajstura
    Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 364:1795-806. 2011
    ..Although progenitor cells have been described in distinct anatomical regions of the lung, description of resident stem cells has remained elusive...
  85. pmc Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements
    Christoph Lepper
    Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
    Nature 460:627-31. 2009
    ..of inducible Cre/loxP lineage tracing and conditional gene inactivation to the tibialis anterior muscle regeneration paradigm, that, unexpectedly, when Pax7 is inactivated in adult mice, mutant satellite cells are not ..
  86. doi Transcription factors lhx1/5-1 and pitx are required for the maintenance and regeneration of serotonergic neurons in planarians
    Ko W Currie
    Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Toronto, ON, Canada
    Development 140:3577-88. 2013
    ..This allows for the analysis of genes required for both the maintenance and regeneration of specific neural subtypes...
  87. ncbi Distinct Wnt signaling pathways have opposing roles in appendage regeneration
    Cristi L Stoick-Cooper
    Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Development 134:479-89. 2007
    ..This process, termed epimorphic regeneration, involves progenitor cells created through the reprogramming of differentiated cells or through the activation ..
  88. pmc Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration
    L M Popescu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    J Cell Mol Med 15:1379-92. 2011
    ..is crucial for regulation of blood flow, passage of substances from capillaries to myocytes and muscle regeneration. We show here, probably, for the first time, the presence of telocytes (TCs), a peculiar type of interstitial (..
  89. doi Wound repair and regeneration
    J M Reinke
    Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany
    Eur Surg Res 49:35-43. 2012
    ..As healing and regeneration processes take place in all parts of the human body, this review focuses on the healing processes of the skin ..
  90. pmc Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration
    Nick R Love
    Faculty of Life Sciences, University of Manchester, UK
    Nat Cell Biol 15:222-8. 2013
    Understanding the molecular mechanisms that promote successful tissue regeneration is critical for continued advancements in regenerative medicine...
  91. doi Satellite cells, the engines of muscle repair
    Yu Xin Wang
    Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute Ottawa, 501 Smyth Road Ottawa, Ontario K1H 8L6, Canada
    Nat Rev Mol Cell Biol 13:127-33. 2011
    ..are a heterogeneous population of stem and progenitor cells that are required for the growth, maintenance and regeneration of skeletal muscle...
  92. pmc The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion
    Jinhu Wang
    Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 138:3421-30. 2011
    Natural models of heart regeneration in lower vertebrates such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in size...
  93. doi Human fetal membranes: a source of stem cells for tissue regeneration and repair?
    S Ilancheran
    Monash Institute of Medical Research, Department of Medicine, Monash University, 27 31 Wright Street, Clayton, Victoria 3168, Australia
    Placenta 30:2-10. 2009
    ..Amniotic epithelial cells also produce numerous substances that could augment tissue regeneration and repair...
  94. pmc Chromatin: the interface between extrinsic cues and the epigenetic regulation of muscle regeneration
    Valentina Guasconi
    Istituto Dulbecco Telethon at Istituto Di Ricovero e Cura a Carattere Scientifico, Santa Lucia Fondazione and European Brain Research Institute, 64 Via del Fosso di Fiorano, Rome, Italy
    Trends Cell Biol 19:286-94. 2009
    Muscle regeneration provides a paradigm by which to study how extrinsic signals coordinate gene expression in somatic stem cells (satellite cells) by directing the genome distribution of chromatin-modifying complexes...
  95. pmc Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea
    Yi Chien Lu
    Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, Farmington, Connecticut 06030 3301, USA
    RNA 15:1483-91. 2009
    ..Together, these results increase the known repertoire of S. mediterranea miRNAs and identify numerous regulated miRNAs that may play important roles in regeneration, homeostasis, neoblast function, and reproduction.
  96. pmc Regulatory interactions between muscle and the immune system during muscle regeneration
    James G Tidball
    Molecular, Cellular and Integrative Physiology Program, Department of Integrative Biology and Physiology, University of California Los Angeles, CA 90095 1606, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1173-87. 2010
    ..Recent discoveries reveal complex interactions between skeletal muscle and the immune system that regulate muscle regeneration. In this review, we evaluate evidence that indicates that the response of myeloid cells to muscle injury ..
  97. ncbi Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
    Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection...
  98. pmc JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
    Benoit Biteau
    Department of Biology, University of Rochester, River Campus Box 270211, Rochester, NY 14627, USA
    Cell Stem Cell 3:442-55. 2008
    ..Here we show that cytoprotective Jun N-terminal kinase (JNK) signaling influences regeneration in the Drosophila gut by directing proliferation of intestinal stem cells (ISCs)...
  99. doi Limbal stem-cell therapy and long-term corneal regeneration
    Paolo Rama
    San Raffaele Scientific Institute, Ophthalmology Unit, Milan, Italy
    N Engl J Med 363:147-55. 2010
    ..We investigated the long-term clinical results of cell therapy in patients with burn-related corneal destruction associated with limbal stem-cell deficiency, a highly disabling ocular disease...
  100. ncbi Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
    Mayumi Ito
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 447:316-20. 2007
    ..These findings suggest treatments for wounds, hair loss and other degenerative skin disorders...
  101. pmc Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration
    Jose E Heredia
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 9001, USA
    Cell 153:376-88. 2013
    ..Here, we demonstrate that type 2 innate immunity is required for regeneration of skeletal muscle after injury...

Research Grants74

  1. Functional Restoration of the Optic Nerve After Disease or Damage
    Dong Feng Chen; Fiscal Year: 2010
    ..of neuroanatomy, cellular biology and mouse behavior tests to probe for mechanisms regulating optic nerve regeneration and restoring vision after injury or diseases...
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..Guided tissue regeneration (GTR) techniques are increasingly being used for the treatment of periodontal defects, or in conjunction with ..
  3. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..biology have greatly expanded our understanding of the biologic processes involved in wound repair and tissue regeneration and have led to improvements in wound care. Cutaneous wound healing differs between fetal and adult skin...
  4. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..We have also found that sphingosine kinase and S1P lyase are dynamically upregulated during murine muscle regeneration, leading to a transient peak in S1P levels in regenerating muscle...
  5. Med1 in Liver Metabolism, Regeneration and Cancer
    Janardan K Reddy; Fiscal Year: 2013
    ..biochemical pathways of carbohydrate, fat, and protein metabolism and exhibits inherent compensatory regeneration capacity to regain partially lost metabolic functions...
  6. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..How does the absence of hepatic retinoid stores influence alcohol-induced liver disease development and liver regeneration? These investigations will involve the use of Lrat-/- mice to explore the role that hepatic retinoid stores and ..
  7. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
    ..More long term solutions include tissue replacement and regeneration therapies, however, the significant challenge of maintaining and stimulating epithelial cell organization and ..
  8. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ..This aim will allow us to determine the strengths and weaknesses of this xenotransplant organ regeneration approach so it can be used in the future to develop tissue and organs of greater complexity such as lung and ..
  9. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    ..Challenge Area (11): Regenerative Medicine, and specific Challenge Topic 11-AR-101 Musculoskeletal and Skin Regeneration Every year, over a million Americans are hospitalized for bone fractures at a cumulative cost of over $100 ..
  10. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..The concentrations of these molecular regulators exhibit temporal variation during regeneration, and this time-dependence is important for successful MuSC activation and preventing fibrosis (Brack, 2007)...
  11. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..PGE2 and CBs, act individually and in concert to exert specific effects on HSCs during embryogenesis and regeneration. This hypothesis has been derived from our own screening results and subsequent preliminary data as well as ..
  12. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012
    ..Tubular regeneration restores normal tubular architecture and renal function following kidney injury...
  13. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..Third, we will capitalize on our novel observation that Nrf2 signaling influences tissue regeneration and repair by examining the post initiation effects of triterpenoids during aflatoxin-induced ..
  14. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    ..However, these medications do not enhance healing and regeneration of bone for a return to normal...
  15. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..identifies areas such as understanding cellular and molecular processes of normal liver cell functioning;liver regeneration and development;and hepatic fibrosis;to make an overall impact on liver health...
  16. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..Information gleaned from these studies will contribute to our understanding of the molecular mechanisms of angiogenesis and hopefully will lead to novel therapeutic modalities for vascular regeneration and anti-angiogenesis therapy.
  17. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..in the carotid arteries of living sheep, and will be imaged in 500[unreadable]m resolution to follow the tissue regeneration and function...
  18. The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide Receptors
    GARY ANDREW WEISMAN; Fiscal Year: 2013
    ..Progress has been made in strategies for the regeneration of a variety of tissues including skin, corneal epithelium, cartilage, bone and bladder...
  19. A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration
    John M Sullivan; Fiscal Year: 2013
    ..and RetDi in RPE cells reflects the normal daily accumulation of ATR from the visual cycle, with bleaching and regeneration of rod and cone opsins, integrated over many years...
  20. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..elevation is common during inflammation after tissue injury and may have an important role in tissue regeneration. However, the mechanisms for temperature-induced bone cell differentiation as well as overexpression of HSPs ..
  21. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..Only by making this change in approach will the ultimate goal of skin regeneration replace the dogma of wound repair which leads to scar and disability...
  22. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    ..human UCB contains a large number of embryonic-like stem cells that have the potential to be used for tissue regeneration in general and myocardial reconstruction in particular...
  23. The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2013
    ..which is utilized by 112-HSD1, thus constituting a connection of H6PDH and 112-HSD1 in regulation of tissue GC regeneration. In support of this, H6PDH knockout mice are unable to regenerate tissue GCs and impaired 112- HSD1 activity...
  24. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation
    Xianxin Hua; Fiscal Year: 2013
    ..Enhancing beta cell proliferation or regeneration can be an effective means to treat type 2 diabetes (T2D)...
  25. MicroRNA Regulation of Macrophage Polarization in Muscle Regeneration
    Paula K Shireman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stem cells and tissue regeneration have great therapeutic promise for treatment of a wide variety of medical conditions...
  26. Roles of RhoA/Rho-kinase Signaling in Cavernous Neurons Following Axonal Injury
    TRINITY JUDE BIVALACQUA; Fiscal Year: 2013
    ..of selective RhoA and ROCK inhibitors effects in the context of neuroregulated erectile function and axonal regeneration are proposed after cavernous nerve injury...
  27. Mechanisms of Astrocyte Development
    Teri L Belecky Adams; Fiscal Year: 2010
    ..component of the nervous system, known as reactive astrocytes, which form permanent barriers to axonal regeneration. Developing optic nerve astrocytes (astrocyte precursors) play a number of roles that are unique to the eye...
  28. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Challenge Area (11) Regenerative Medicine: 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, hematology, kidneys and urological system...
  29. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    ..In the injured nervous system, EphA4 inhibits nerve regeneration and functional recovery by promoting glial scar formation and inhibiting sprouting of injured axons...
  30. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    ..The bone morphogenetic proteins (BMPs) are used as therapeutic measures for promoting bone regeneration. Recent reports suggest that BMPs act on osteoclasts indirectly through osteoblasts or stromal cells...
  31. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    ..These stromal cells provide the niche and could supply critical growth factor/signals for ISC regeneration. For example, upon intestinal mucosal disruption, resident macrophages in the intestinal submucosal layers are ..
  32. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..suggest that hepatocyte growth factor (HGF), a pleiotropic cytokine, has multiple activities that lead to lung regeneration. Such activities include promotion of elastin synthesis, suppression of apoptosis, suppression of inflammation, ..
  33. Microfluidic-microtiter interface for rapid large-scale screenings of C. elegans
    Adela Ben Yakar; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): After injury, unlike the axons of the central nervous system where the regeneration process is poor or absent, axons of the peripheral nervous system are able to regenerate, though inefficiently...
  34. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..the use of vascular gene therapy in a clinical setting and uncovering alternative approaches to vascular regeneration and remodeling...
  35. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..Biology includes fourteen full-time faculty that study various questions centered on the development, regeneration, and patterning of organs...
  36. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..The PANIC ATTAC mouse allows the unique opportunity to evaluate beta cell regeneration following the cell specific and titratable induction of apoptosis.
  37. INDUCIBLE PLURIPOTENT STEM CELLS AND KIDNEY REGENERATION
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..addresses broad Challenge Area (11) Regenerative Medicine and specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, hematologic, and urologic system...
  38. Pbx Homeodomain Proteins in Skeletal Muscle Differentiation
    LISA A MAVES; Fiscal Year: 2011
    ..muscle precursor cells into contractile skeletal muscle fibers is necessary for normal muscle development and regeneration and, when defective, leads to musculoskeletal diseases such as muscular dystrophies and muscle tumors...
  39. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Endogenous regeneration of the thymus is a crucial function that allows for renewal of immune competence following infection, shock or common cancer therapies such as cytoreductive chemo- or radiation ..
  40. IL-22 in epithelial regeneration after allogeneic transplant
    Alan Hanash; Fiscal Year: 2013
    ..will not only lead to better understanding of immunobiology, intestinal stem cell physiology, epithelial regeneration, and GVHD pathophysiology, but will also lead to the development novel strategies to reduce epithelial damage ..
  41. Mechanisms mediating hematopoietic stem and progenitor cell trafficking
    Paul S Frenette; Fiscal Year: 2013
    ..Our preliminary studies suggest that a lesion to the SNS impairs the regeneration of the niche and recovery of hematopoiesis following a stressful challenge such as stem cell transplantation or ..
  42. Towards Induction of Cell Transplant Tolerance
    Lina Lu; Fiscal Year: 2013
    ..HSC are the main retinoid storing cells in the body and are known to be actively involved in liver repair and regeneration by synthesizing extracellular matrix protein and secretion of cytokines and growth factors...
  43. IL-22 in Thymic Regeneration
    Marcel R m van den Brink; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Endogenous regeneration of the thymus is a crucial function that allows for renewal of immune competence following infection, shock, cytoreductive chemo- or radiation therapy and other causes of ..
  44. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
    ..order to achieve this goal, we first need to identify the molecular genetic pathways that will lead to sensory regeneration. Until now our insights into these processes were limited by genomic tools that were either not cost effective ..
  45. Astrocyte Development and Reactive Gliosis
    Teri L Belecky-Adams; Fiscal Year: 2012
    ..eye, these cells become reactive, whereupon they begin expressing molecules that are unfavorable to the regeneration of the optic nerve...
  46. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2013
    ..Biology includes fourteen full-time faculty that study various questions centered on the development, regeneration, and patterning of organs...
  47. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
    ..studies that identify and develop new therapeutic strategies that attenuate hepatocyte death, promote hepatic regeneration and improve outcome...
  48. Core Center for BioBehavioral Sciences of Communication Disorders
    Mabel L Rice; Fiscal Year: 2013
    ..as a predictor of later cognitive and language development, clinical trials with a viral vector to induce regeneration of vestibular hair cells for the treatment of tinnitus/balance disorders, and gene regulation of axon growth ..
  49. White Matter Protection in Cerebral Ischemia
    Guodong Cao; Fiscal Year: 2013
    ..central hypothesis to be tested is that NAMPT protects against WMI via enhancing oligodendrocytic protection/ regeneration and microglia-mediated myelin phagocytosis...
  50. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
    ..cell response to injury and 2) microvascular endothelial cells secrete neurotrophins that regulate nerve fiber regeneration. We will test our hypothesis by addressing the following aims: 1) To determine effects of nervederived ..
  51. FIBROBLAST DIFFERENTIATION DURING EYE DEVELOPMENT
    Gary W Conrad; Fiscal Year: 2012
    ..Resulting regeneration and wound healing reactions of surrounding surviving corneal nerves and keratocytes involve cellular migrations ..
  52. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation.
    Xianxin Hua; Fiscal Year: 2010
    ..Enhancing beta cell proliferation or regeneration can be an effective means to treat type 2 diabetes (T2D)...
  53. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In damaged skin, regeneration is not the same as filling and resurfacing...
  54. Mitoenergetic Failure in Brain Aging
    Gregory J Brewer; Fiscal Year: 2013
    ..have recent evidence that mitochondria from old rat neurons in culture promote normal neuron survival, normal regeneration, normal glucose uptake and normal respiration, but do so with decrepit mitochondria which fail to upregulate ..
  55. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    DESCRIPTION (provided by the applicant): Incomplete liver regeneration is an obstacle to recovery from liver disease and for patients who receive grafts through living-donor liver transplantation...
  56. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2012
    ..model system that I have developed for the study of molecular mechanisms of nephrotic syndrome and podocyte regeneration. This will aid the transition of my research career toward an independent investigator position...
  57. Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem Cells
    RUBIE ANN RAKIAN; Fiscal Year: 2013
    ..vitro;2) Demonstrate the capacity of predifferentiated MSCs maintained on AlloDerm for oral mucosa epithelium regeneration in vivo using an athymic nude mouse model...
  58. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    ..and triggers signal transduction that protects cells against apoptosis and enhances cell growth for tissue regeneration. The profound effects of HGF to prevent cell death and to promote tissue regeneration make HGF an interesting ..
  59. ENDOGENOUS MODULATION OF COCHLEAR INJURY
    Leonard P Rybak; Fiscal Year: 2012
    ..It is induced in kidney by cisplatin. This molecule may enhance repair and regeneration of proximal tubule cells...
  60. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
    ..expressed primarily in epithelial cells and appears to be necessary for the differentiation, maintenance, and regeneration of epithelial stem cells. In addition, mutant mice have developmental abnormalities...
  61. IKKbeta:Bi-Functional Regulator of Hepatocyte Proliferation
    Hyam L Leffert; Fiscal Year: 2010
    ..by applicant): The long-term goals of this proposal are directed towards understanding mechanisms of liver regeneration and hepatocarcinogenesis...
  62. Cytotoxic-T-Lymphocyte (CTL) Therapy of AML
    Bruce R Blazar; Fiscal Year: 2013
    ..Hypothesis: LN stroma regeneration will increase immune function...
  63. Laser Spinning Disc Confocal System for live-cell and live-organism microscopy
    Martha C Soto; Fiscal Year: 2012
    ..understanding of such essential cellular phenomena as protein trafficking, polarization of the cytoskeleton and regeneration in neurons...
  64. Cardiac Regeneration through Growth Factor Eluting Microrod Scaffolds
    Paul H Goldspink; Fiscal Year: 2013
    ..proposed in this application combines bioengineering and cell biology-based techniques to directly target the regeneration of heart muscle, which is an important clinical problem not well addressed by current therapies...
  65. Biomimetic scaffolds for targeted peripheral nerve regeneration
    DAVID SHREIBER; Fiscal Year: 2009
    ..The broad, long-term objective of this research is to develop an implantable construct for peripheral nerve regeneration following nerve trauma...
  66. microRNA Uncoupling of Protein and Transcript Expression in Liver Regeneration
    CLIFFORD JOHN STEER; Fiscal Year: 2010
    ..Our hypothesis is that microRNAs are required for liver regeneration and primarily responsible for the observed uncoupling of protein and transcript expression after PH...
  67. METABOLIC HOMEOSTASIS IN LIVER REGENERATION
    LINDA GREENBAUM; Fiscal Year: 1999
    Liver regeneration following partial hepatectomy is one of the few models in which it is possible to study cellular proliferation in the intact animal...
  68. Intravenous Protein Therapy for Treatment of Congenital Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..A substantial delay in muscle regeneration occurs when skeletal muscle degeneration of dyW is provoked by notexin, indicating that an additional ..
  69. STEROID HORMONES AND NEURONAL REGENERATION
    Kathryn Jones; Fiscal Year: 2001
    DESCRIPTION: The investigator has identified a role for testosterone propionate (TP) in enhancing neuronal regeneration of the crushed facial nerve in adult hamsters...
  70. MOLECULAR CONTROL OF LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    DESCRIPTION: Liver regeneration following partial hepatectomy provides one of the few examples of a physiologic growth response occurring in the intact animal...
  71. Molecular Heparan Sulfate Delivery in Guided Tissue Regeneration
    Arthur A Decarlo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Barrier membranes are an important adjunct to regeneration therapy aimed at restoring the form and function of the mouth...
  72. REGENERATION IN THE SPINAL CORD-ROLE OF NEUROFILAMENT
    MICHAEL SELZER; Fiscal Year: 2003
    ..from applicant's abstract): This revised application makes use of the sea lamprey as a model system for axon regeneration in the CNS...
  73. Gene profiling of nervous system regeneration using a novel model organism
    Jose E Garcia Arraras; Fiscal Year: 2010
    Gene profiling of nervous system regeneration using a novel model organism Post-traumatic regeneration of neurons and fibers in the mammalian spinal cord has not been plausible, even though extensive studies have been made to understand ..
  74. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2006
    ..or the lack of a good growth supportive substrate, produce an environment that is refractory to axonal regeneration. This application is designed to examine the hypothesis that a selective expression of growth-supportive and ..