recovery of function


Summary: A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.

Top Publications

  1. ncbi What do motor "recovery" and "compensation" mean in patients following stroke?
    Mindy F Levin
    School of Physical and Occupational Therapy, McGill University and Center for Interdisciplinary Research in Rehabilitation, Jewish Rehabilitation Hospital, Montreal, Quebec, Canada
    Neurorehabil Neural Repair 23:313-9. 2009
  2. pmc Effects of robot-assisted therapy on upper limb recovery after stroke: a systematic review
    Gert Kwakkel
    Department Rehabilitation Medicine and Research Institute MOVE, VU University Medical Center Amsterdam, The Netherlands
    Neurorehabil Neural Repair 22:111-21. 2008
  3. ncbi Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006
  4. ncbi Robot-assisted therapy for long-term upper-limb impairment after stroke
    Albert C Lo
    Providence Veterans Affairs Medical Center and Brown University, Providence, RI 02909, USA
    N Engl J Med 362:1772-83. 2010
  5. ncbi Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
  6. ncbi A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    J Neurosci 26:13007-16. 2006
  7. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
  8. ncbi Motor recovery after stroke: a systematic review
    Peter Langhorne
    Stroke Therapy Evaluation Programme, Academic Section of Geriatric Medicine, Cardiovascular and Medical Sciences Division, Royal Infirmary, Glasgow, UK
    Lancet Neurol 8:741-54. 2009
  9. ncbi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
  10. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009

Detail Information

Publications320 found, 100 shown here

  1. ncbi What do motor "recovery" and "compensation" mean in patients following stroke?
    Mindy F Levin
    School of Physical and Occupational Therapy, McGill University and Center for Interdisciplinary Research in Rehabilitation, Jewish Rehabilitation Hospital, Montreal, Quebec, Canada
    Neurorehabil Neural Repair 23:313-9. 2009
  2. pmc Effects of robot-assisted therapy on upper limb recovery after stroke: a systematic review
    Gert Kwakkel
    Department Rehabilitation Medicine and Research Institute MOVE, VU University Medical Center Amsterdam, The Netherlands
    Neurorehabil Neural Repair 22:111-21. 2008
    ..The aim of the study was to present a systematic review of studies that investigate the effects of robot-assisted therapy on motor and functional recovery in patients with stroke...
  3. ncbi Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006
    ..05). The differing behavioral response to SCI suggests inherent genetic factors significantly impact locomotor recovery and must be considered in studies with inbred or genetically engineered mouse strains...
  4. ncbi Robot-assisted therapy for long-term upper-limb impairment after stroke
    Albert C Lo
    Providence Veterans Affairs Medical Center and Brown University, Providence, RI 02909, USA
    N Engl J Med 362:1772-83. 2010
    ..Effective rehabilitative therapies are needed for patients with long-term deficits after stroke...
  5. ncbi Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
  6. ncbi A neurovascular niche for neurogenesis after stroke
    John J Ohab
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1735, USA
    J Neurosci 26:13007-16. 2006
    ..These experiments define a novel brain environment for neuronal regeneration after stroke and identify molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury...
  7. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  8. ncbi Motor recovery after stroke: a systematic review
    Peter Langhorne
    Stroke Therapy Evaluation Programme, Academic Section of Geriatric Medicine, Cardiovascular and Medical Sciences Division, Royal Infirmary, Glasgow, UK
    Lancet Neurol 8:741-54. 2009
    ..Although the existing evidence is limited by poor trial designs, some treatments do show promise for improving motor recovery, particularly those that have focused on high-intensity and repetitive task-specific practice...
  9. ncbi Plasticity during stroke recovery: from synapse to behaviour
    Timothy H Murphy
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Nat Rev Neurosci 10:861-72. 2009
    ..The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury...
  10. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
    ..These findings provide a strategy by which individuals with spinal cord injuries could regain substantial levels of motor control...
  11. ncbi Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature
    Olivier Ethgen
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Diseases, Department of Public Health, Epidemiology, and Health Economics, University of Liege, Belgium, Liege, Belgium
    J Bone Joint Surg Am 86:963-74. 2004
    ..The objective of this study was to review the literature regarding the outcomes of total hip and knee arthroplasties as evaluated by health-related quality-of-life instruments...
  12. ncbi Understanding the pattern of functional recovery after stroke: facts and theories
    Gert Kwakkel
    Rehabilitation Centre De Hoogstraat, Rudolf Magnus Institute of Neuroscience, NL 3583 UMC Utrecht, The Netherlands
    Restor Neurol Neurosci 22:281-99. 2004
  13. ncbi Interhemispheric competition after stroke: brain stimulation to enhance recovery of function of the affected hand
    Dennis A Nowak
    Department of Neurology, University Hospital, University of Cologne, Cologne, Germany
    Neurorehabil Neural Repair 23:641-56. 2009
    ..This review critically summarizes the data supporting the use of novel electrophysiological concepts in the rehabilitation of hand function after stroke...
  14. pmc Structural integrity of corticospinal motor fibers predicts motor impairment in chronic stroke
    R Lindenberg
    Department of Neurology, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Neurology 74:280-7. 2010
  15. ncbi Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial
    Francois Chollet
    Neurology Department, Centre Hospitalier Universitaire de Toulouse, Hopital Purpan, Toulouse, France
    Lancet Neurol 10:123-30. 2011
    ..We therefore aimed to investigate whether fluoxetine would enhance motor recovery if given soon after an ischaemic stroke to patients who have motor deficits...
  16. ncbi Predicting the outcome of total knee arthroplasty
    Elizabeth A Lingard
    Brigham and Women s Hospital, 75 FrancisStreet, Boston, MA 02115, USA
    J Bone Joint Surg Am 86:2179-86. 2004
    ..This paper examines the preoperative predictors of pain and functional outcome at one and two years following total knee arthroplasty...
  17. ncbi The development of a comorbidity index with physical function as the outcome
    Dianne L Groll
    Department of Surgery, Queen s University, Kingston, Ontario, Canada
    J Clin Epidemiol 58:595-602. 2005
    ..The objective of this study was to develop a self-administered Functional Comorbidity Index with physical function as the outcome...
  18. pmc Neural correlates of outcome after stroke: a cross-sectional fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:1430-48. 2003
    ..These results further our understanding of the recovery process by demonstrating for the first time a clear relationship between task-related activation of the motor system and outcome after stroke...
  19. ncbi Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Japan
    Cell 110:429-41. 2002
    ..These results expand the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases...
  20. ncbi Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity
    Maurits P A van Meer
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 32:4495-507. 2012
  21. pmc Urinary biomarkers and renal recovery in critically ill patients with renal support
    Nattachai Srisawat
    604 Scaife Hall, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 6:1815-23. 2011
    ..Unfortunately, no reliable method to predict renal recovery exists. The discovery of biomarkers to aid in clinical risk prediction for recovery after AKI would represent a significant advance over current practice...
  22. ncbi Task-specific training: evidence for and translation to clinical practice
    Isobel J Hubbard
    Acute Stroke Unit, John Hunter Hospital, Hunter New England Area Health Service, Newcastle, and The University of Newcastle, Newcastle, Australia
    Occup Ther Int 16:175-89. 2009
  23. ncbi Dynamics of language reorganization after stroke
    Dorothee Saur
    Department of Neurology, University Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Brain 129:1371-84. 2006
    ..Thereafter, a normalization of activation is observed, possibly reflecting consolidation in the language system...
  24. ncbi Functional neuroimaging studies of motor recovery after stroke in adults: a review
    Cinzia Calautti
    Department of Neurology, University of Cambridge, Cambrid, UK
    Stroke 34:1553-66. 2003
    ..Reorganization of the motor system after stroke as assessed by functional neuroimaging is an intriguing but challenging new field of research. Provocative but equivocal findings have been reported to date...
  25. pmc Spinal cord injury: a systematic review of current treatment options
    David W Cadotte
    Division of Neurosurgery, University of Toronto, and Neural Repair and Regeneration, Spinal Program, University Health Network, Toronto Western Hospital, Toronto, ON, Canada
    Clin Orthop Relat Res 469:732-41. 2011
    ..Research has revealed an understanding of mechanisms that occur after the primary injury and contribute to functional loss. By targeting these secondary mechanisms of injury, clinicians may be able to offer improved recovery after SCI...
  26. ncbi Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations
    Anthony H Aletras
    National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circulation 113:1865-70. 2006
  27. pmc Neural correlates of motor recovery after stroke: a longitudinal fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:2476-96. 2003
    ..These results further our understanding of the recovery process by demonstrating for the first time a clear temporal relationship between recovery and task-related activation of the motor system after stroke...
  28. ncbi Movement smoothness changes during stroke recovery
    Brandon Rohrer
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 22:8297-304. 2002
    ..This pattern was reproduced in a computer simulation of recovery based on submovement blending, suggesting that progressive blending of submovements underlies stroke recovery...
  29. ncbi Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury
    Soheila Karimi-Abdolrezaee
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:3377-89. 2006
    ..Our data provide strong evidence in support of the feasibility of adult NPCs for cell-based remyelination after SCI...
  30. pmc Patient satisfaction after total knee arthroplasty: who is satisfied and who is not?
    Robert B Bourne
    University Hospital, London Health Sciences Centre, University of Western Ontario, 339 Windermere Road, London, ON N6A 5A5, Canada
    Clin Orthop Relat Res 468:57-63. 2010
    ..7x greater risk), a low 1-year WOMAC (2.5x greater risk), preoperative pain at rest (2.4x greater risk) and a postoperative complication requiring hospital readmission (1.9x greater risk)...
  31. ncbi Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender
    Xiaoling Li
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Exp Neurol 187:94-104. 2004
    ..This suggests that a short battery of tests including the neurological score, cylinder, and corner test may be adequate to rapidly and repeatedly assess sensorimotor dysfunction in mice of both genders...
  32. pmc Mental practice with motor imagery in stroke recovery: randomized controlled trial of efficacy
    Magdalena Ietswaart
    Department of Psychology, School of Life Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
    Brain 134:1373-86. 2011
    ..In light of the evidence, it remains to be seen whether mental practice with motor imagery is a valid rehabilitation technique in its own right...
  33. ncbi Evidence-based surgical care and the evolution of fast-track surgery
    Henrik Kehlet
    Section of Surgical Pathophysiology 4074, Rigshospitalet, Copenhagen, Denmark
    Ann Surg 248:189-98. 2008
    ..Optimization of postoperative outcome requires the application of evidence-based principles of care carefully integrated into a multimodal rehabilitation program...
  34. ncbi The impact of physical therapy on functional outcomes after stroke: what's the evidence?
    R P S Van Peppen
    Department of Physical Therapy, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Rehabil 18:833-62. 2004
    ..To determine the evidence for physical therapy interventions aimed at improving functional outcome after stroke...
  35. ncbi Role of adaptive plasticity in recovery of function after damage to motor cortex
    R J Nudo
    Center on Aging and Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 5026 Wescoe Pavilion, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Muscle Nerve 24:1000-19. 2001
  36. pmc Anterior temporal lobe connectivity correlates with functional outcome after aphasic stroke
    Jane E Warren
    Cognitive Neuroimaging Group, MRC Cyclotron Unit, Hammersmith Hospital, London W120NN, UK
    Brain 132:3428-42. 2009
  37. ncbi Comparison of the action research arm test and the Fugl-Meyer assessment as measures of upper-extremity motor weakness after stroke
    Meheroz H Rabadi
    Weill Medical College of Cornell University, Burke Rehabilitation Hospital, White Plains, NY 10605, USA
    Arch Phys Med Rehabil 87:962-6. 2006
  38. ncbi Global test statistics for treatment effect of stroke and traumatic brain injury in rats with administration of bone marrow stromal cells
    Mei Lu
    Department of Biostatistics and Research Epidemiology, Henry Ford Health Sciences Center, One Ford Place, 3E, Detroit, MI 48202, USA
    J Neurosci Methods 128:183-90. 2003
    ..We demonstrated that the global test for continuous outcomes could be implemented under careful statistical modeling and proper data transformation...
  39. ncbi The timed up & go test: its reliability and association with lower-limb impairments and locomotor capacities in people with chronic stroke
    Shamay S Ng
    Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong SAR, China
    Arch Phys Med Rehabil 86:1641-7. 2005
  40. ncbi The effect of mild post-stroke exercise on reactive neurogenesis and recovery of somatosensation in aged rats
    J Leigh Leasure
    Department of Psychology, University of Houston, Houston, TX 77204, USA
    Exp Neurol 226:58-67. 2010
    ..Our results underscore the need for further study of clinically relevant post-stroke exercise regimens...
  41. ncbi Influence of interhemispheric interactions on motor function in chronic stroke
    Nagako Murase
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Ann Neurol 55:400-9. 2004
    ..It is conceivable that this abnormality could adversely influence motor recovery in some patients with subcortical stroke, an interpretation consistent with models of interhemispheric competition in motor and sensory systems...
  42. ncbi Recovery in mechanical muscle strength following resurfacing vs standard total hip arthroplasty - a randomised clinical trial
    C Jensen
    Orthopaedic Research Unit, Dept of Orthopaedic Surgery and Traumatology, Odense University Hospital, Inst of Clinical Research, University of Southern Denmark, Denmark
    Osteoarthritis Cartilage 19:1108-16. 2011
  43. ncbi The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute and New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08820, USA
    Arch Phys Med Rehabil 85:2020-9. 2004
    ..To determine the measurement properties and diagnostic utility of the JFK Coma Recovery Scale-Revised (CRS-R)...
  44. pmc The John Charnley Award: Metal-on-metal hip resurfacing versus large-diameter head metal-on-metal total hip arthroplasty: a randomized clinical trial
    Donald S Garbuz
    Division of Lower Limb Reconstruction and Oncology, Department of Orthopaedics, University of British Columbia, Room 3114, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, Canada
    Clin Orthop Relat Res 468:318-25. 2010
    ..6-fold higher than in the resurfacing arm. Due to these excessively high metal ion levels, the authors recommend against further use of this particular large-head total hip arthroplasty...
  45. ncbi Locomotor training improves daily stepping activity and gait efficiency in individuals poststroke who have reached a "plateau" in recovery
    Jennifer L Moore
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, IL, USA
    Stroke 41:129-35. 2010
  46. ncbi The effect of voluntary exercise exposure on histological and neurobehavioral outcomes after ischemic brain injury in the rat
    Raul Marin
    Department of the Army, Walter Reed Army Medical Center, 6900 Georgia Avenue, Washington, DC 20307, USA
    Physiol Behav 80:167-75. 2003
  47. ncbi Analysis of fMRI and finger tracking training in subjects with chronic stroke
    James R Carey
    Program in Physical Therapy, University of Minnesota, Minneapolis 55455, USA
    Brain 125:773-88. 2002
    ..We concluded that individuals with chronic stroke receiving intensive tracking training showed improved tracking accuracy and grasp and release function, and that these improvements were accompanied by brain reorganization...
  48. ncbi Recovery from brain injury in animals: relative efficacy of environmental enrichment, physical exercise or formal training (1990-2002)
    Bruno Will
    Laboratoire de Neurosciences Comportementales et Cognitives, Institut Fédératif des Neurosciences, Universite Louis Pasteur, UMR 7521, CNRS, Strasbourg, France
    Prog Neurobiol 72:167-82. 2004
    ..Finally, other recent reports emphasize that the treatment parameters may be changed in order to approximate clinical/rehabilitation conditions and, nevertheless, remain effective...
  49. pmc Motor imagery after stroke: relating outcome to motor network connectivity
    Nikhil Sharma
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Ann Neurol 66:604-16. 2009
    ..This raises an important question: how far does recovery of motor performance depend on the processes that precede movement execution involving the premotor and prefrontal cortex, rather than recovery of the corticospinal system alone?..
  50. ncbi Interpreting change scores for pain and functional status in low back pain: towards international consensus regarding minimal important change
    Raymond W J G Ostelo
    EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    Spine (Phila Pa 1976) 33:90-4. 2008
    ..Literature review, expert panel, and a workshop during the "VIII International Forum on Primary Care Research on Low Back Pain" (Amsterdam, June 2006)...
  51. ncbi Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome
    D Lu
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Neuroreport 12:559-63. 2001
    ..MSCs were also found in other organs and primarily localized to the vascular structures, without any obvious adverse effects. Our data suggest that i.v. administration of MSCs may be useful in the treatment of TBI...
  52. ncbi Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury
    J Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    J Neurosci 21:5272-80. 2001
  53. ncbi Prospective, blinded, randomized crossover study of gait rehabilitation in stroke patients using the Lokomat gait orthosis
    Andreas Mayr
    Department of Neurology, Hospital Hochzirl, Zirl, Austria
    Neurorehabil Neural Repair 21:307-14. 2007
    ..This prospective, blinded, randomized controlled study of gait retraining tested the feasibility and potential efficacy of using an electromechanical-driven gait orthosis (Lokomat) for treadmill training...
  54. ncbi Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia
    R L Zhang
    Department of Neurology, Henri Ford Health Sciences Center, Detroit, MI 48202, USA
    Neuroscience 105:33-41. 2001
    ..From these data we suggest that focal cerebral ischemia induces transient and regional specific increases in cell proliferation in the ipsilateral hemisphere and that proliferating progenitor cells may exist in the adult cortex...
  55. ncbi Functional outcome at 2.5, 5, 9, and 24 months after injury in the Netherlands
    Suzanne Polinder
    Department of Public Health, ErasmusMC University Medical Center Rotterdam, The Netherlands
    J Trauma 62:133-41. 2007
    ..The collection of empirical data on the frequency, severity, and duration of functioning is a prerequisite to identify patient groups with long term or permanent disability...
  56. ncbi The importance of patient expectations in predicting functional outcomes after total joint arthroplasty
    Nizar N Mahomed
    Division of Orthopaedic Surgery, Toronto Western Hospital, University of Toronto, ON, Canada
    J Rheumatol 29:1273-9. 2002
    ..Multivariate regression models were used to evaluate the impact of expectations on outcomes...
  57. ncbi Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats
    Michelle Ploughman
    Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Stroke 40:1490-5. 2009
    ..We tested this hypothesis by evaluating the contribution of BDNF to motor skill relearning after endothelin-1-induced middle cerebral artery occlusion in rats...
  58. ncbi Neural basis and recovery of spatial attention deficits in spatial neglect
    Maurizio Corbetta
    Department of Neurology, Washington University, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 8:1603-10. 2005
  59. ncbi Robot-based hand motor therapy after stroke
    Craig D Takahashi
    Department of Neurology, University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868 4280, USA
    Brain 131:425-37. 2008
    ..A robot-based therapy showed improvements in hand motor function after chronic stroke. Reorganization of motor maps during the current therapy was task-specific, a finding useful when considering generalization of rehabilitation therapy...
  60. ncbi Virtual reality in stroke rehabilitation: a systematic review of its effectiveness for upper limb motor recovery
    Amy Henderson
    Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Top Stroke Rehabil 14:52-61. 2007
    ..One intervention showing promise is virtual reality (VR), using either immersive or nonimmersive technology. Before recommending VR for use in clinical practice, it is important to understand the evidence regarding its effectiveness...
  61. ncbi Reliability of gait performance tests in men and women with hemiparesis after stroke
    Ulla Britt Flansbjer
    Department of Rehabilitation, Lund University Hospital, Lund, Sweden ulla britt
    J Rehabil Med 37:75-82. 2005
    ..To assess the reliability of 6 gait performance tests in individuals with chronic mild to moderate post-stroke hemiparesis...
  62. pmc Why use a connectivity-based approach to study stroke and recovery of function?
    Alex R Carter
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 62:2271-80. 2012
    ..A connectivity-based approach will provide greater insight into network reorganization in the acute and chronic phases after stroke and will contribute to improving prognostic ability and the development of therapeutic interventions...
  63. ncbi Strategies to restore motor functions after spinal cord injury
    Pascale Boulenguez
    Laboratoire Plasticité et Physio Pathologie de Motricité UMR6196, Centre National de Recherche Scientifique CNRS and Aix Marseille Université, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille cx 20, France
    Curr Opin Neurobiol 19:587-600. 2009
    ..Finally, improvements in the understanding of the mechanisms underlying spasticity may lead to new treatments of this disabling complication affecting patients with SCI...
  64. ncbi Cell replacement therapies for central nervous system disorders
    A Bjorklund
    The authors are at the Wallenberg Neuroscience Center, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Nat Neurosci 3:537-44. 2000
    ..Clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain. But how realistic is it that cell replacement can be developed into effective clinical therapy?..
  65. pmc Motor system activation after subcortical stroke depends on corticospinal system integrity
    Nick S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 129:809-19. 2006
    ..Secondary motor regions are less efficient at generating motor output so this reorganization can only be considered partially successful in reducing motor impairment after stroke...
  66. ncbi Mechanisms of neural plasticity following brain injury
    Tadeusz Wieloch
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, University of Lund, BMCA13, 221 85 Lund, Sweden
    Curr Opin Neurobiol 16:258-64. 2006
    ..These new mechanistic insights are aiding the design of novel therapeutic modalities that enhance regeneration...
  67. ncbi Rasch analysis of a new stroke-specific outcome scale: the Stroke Impact Scale
    Pamela W Duncan
    Brooks Center for Rehabilitation Studies, University of Florida, Gainesville, FL 32610 0185, USA
    Arch Phys Med Rehabil 84:950-63. 2003
    ..To assess multiple psychometric characteristics of a new stroke outcome measure, the Stroke Impact Scale (SIS), using Rasch analysis, and to identify and remove misfitting items from the 8 domains that comprise the SIS...
  68. ncbi cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury
    Damien D Pearse
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA
    Nat Med 10:610-6. 2004
    ..These findings show that cAMP levels are key for protection, growth and myelination of injured CNS axons in vivo and recovery of function.
  69. ncbi The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
    Florence M Bareyre
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 7:269-77. 2004
    ..Hence, after incomplete spinal cord injury, spontaneous extensive remodeling occurs, based on axonal sprout formation and removal. Such remodeling may be crucial for rehabilitation in humans...
  70. ncbi Health related quality of life outcomes after total hip and knee arthroplasties in a community based population
    C A Jones
    Department of Public Health Sciences, University of Alberta, Edmonton, Canada
    J Rheumatol 27:1745-52. 2000
    ..To quantify the magnitude of change seen with pain, function, and quality of life outcomes 6 months after total hip and knee arthroplasties (THA, TKA) within a community based cohort of a regional health district...
  71. ncbi Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Brain 135:1253-67. 2012
    ..Our findings establish the anatomical, functional and molecular basis for the intrinsic capacity of neurons to form compensatory neural network following injury...
  72. ncbi Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury
    Difei Wang
    Cambridge University Centre for Brain Repair, Cambridge CB2 0PY, United Kingdom
    J Neurosci 31:9332-44. 2011
    ..Our results indicate that ChABC treatment opens a window of opportunity in chronic spinal cord lesions, allowing rehabilitation to improve functional recovery...
  73. ncbi Targeting recovery: priorities of the spinal cord-injured population
    Kim D Anderson
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697 4292, USA
    J Neurotrauma 21:1371-83. 2004
    ..In order to improve the relevance of research in this area, the concerns of the SCI population must be better known and taken into account. This approach is consistent with and emphasized by the new NIH roadmap to discovery...
  74. pmc Recovery of activities of daily living in older adults after hospitalization for acute medical illness
    Cynthia M Boyd
    Department of Medicine, Division of Geriatric Medicine, School of Medicine, John Hopkins University, Baltimore, Maryland 21224, USA
    J Am Geriatr Soc 56:2171-9. 2008
  75. ncbi Robot-assisted rehabilitation of hand function
    Sivakumar Balasubramanian
    Department of Bioengineering, Imperial College of Science, Technology and Medicine, London, UK
    Curr Opin Neurol 23:661-70. 2010
    ..However, recent years have seen a surge in devices dedicated to hand function. This review describes the state of the art and the promises of this novel therapeutic approach...
  76. ncbi BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats
    R Vavrek
    University of Alberta, Faculty of Rehabilitation Medicine, Edmonton, Alberta, Canada
    Brain 129:1534-45. 2006
    ..Hence, cell body treatment can promote plasticity of the injured CNS and may be a valuable treatment approach in conjunction with local regeneration promoting strategies...
  77. ncbi Endurance exercise facilitates relearning of forelimb motor skill after focal ischemia
    Michelle Ploughman
    Basic Medical Sciences, Faculty of Medicine, Memorial University, St John s, NL, Canada A1B 3V6
    Eur J Neurosci 25:3453-60. 2007
    ..These findings suggest that exercise facilitates learning of subsequent challenging reaching tasks after stroke, which has the potential to optimize outcomes in patients with stroke...
  78. pmc Mechanisms underlying recovery of motor function after stroke
    Nick S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, England
    Arch Neurol 61:1844-8. 2004
    ..of new effective therapeutic strategies relies on a better understanding of the mechanisms underlying recovery of function. Noninvasive techniques to study brain function, including functional magnetic resonance imaging, positron ..
  79. pmc The EXCITE stroke trial: comparing early and delayed constraint-induced movement therapy
    Steven L Wolf
    Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Stroke 41:2309-15. 2010
  80. pmc Promoting axonal rewiring to improve outcome after stroke
    Larry I Benowitz
    Laboratories for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Program, Children s Hospital, USA
    Neurobiol Dis 37:259-66. 2010
    ..These approaches represent a marked departure from the recent focus on neuroprotection and may provide a more effective way to improve outcome after stroke...
  81. ncbi Stem cells for the treatment of spinal cord injury
    Margaret Coutts
    Reeve Irvine Research Center, Stem Cell Research Center, Department of Anatomy and Neurobiology, College of Medicine, University of California Irvine, Irvine, CA, USA
    Exp Neurol 209:368-77. 2008
    ..With a growing understanding of these practical issues, stem cell biology, and spinal cord injury pathophysiology, stem cell-based therapies are moving closer to clinical application...
  82. ncbi Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
    Guillermo Garcia-Alias
    Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
    Nat Neurosci 12:1145-51. 2009
    ..Our results indicate that chondroitinase treatment opens a window during which rehabilitation can promote recovery. However, only the trained skills are improved and other functions may be negatively affected...
  83. ncbi Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage
    Jeffrey A Kleim
    McKnight Brain Institute, University of Florida, Gainesville, and Brain Rehabilitation Research Center 151A, Malcom Randall VA Hospital, 1610 SW Archer Road, Gainesville, FL 32610, USA
    J Speech Lang Hear Res 51:S225-39. 2008
    ..This paper reviews 10 principles of experience-dependent neural plasticity and considerations in applying them to the damaged brain...
  84. ncbi Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery
    Steven C Cramer
    Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92868 4280, USA
    Ann Neurol 63:272-87. 2008
    ..Such measures gain importance when viewed as covariates in therapeutic trials of restorative agents that target stroke recovery...
  85. ncbi Probability of regaining dexterity in the flaccid upper limb: impact of severity of paresis and time since onset in acute stroke
    Gert Kwakkel
    Rehabilitation Centre De Hoogstraat, University Medical Centre, Utrecht, The Netherlands
    Stroke 34:2181-6. 2003
  86. pmc Remodeling the brain: plastic structural brain changes produced by different motor therapies after stroke
    Lynne V Gauthier
    Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Stroke 39:1520-5. 2008
    ..This study evaluated whether evidence could also be found for structural brain changes during an efficacious rehabilitation program...
  87. ncbi Early exercise in critically ill patients enhances short-term functional recovery
    Chris Burtin
    Faculty of Kinesiology and Rehabilitation Sciences CB, BC, CR, DL, TT, RG, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 37:2499-505. 2009
    ..No evidence is available concerning the effectiveness of an early exercise training intervention to prevent these detrimental complications...
  88. ncbi Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia
    A Ramon-Cueto
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Neuron 25:425-35. 2000
    ..Therefore, OEG transplantation provides a useful repair strategy in adult mammals with traumatic spinal cord injuries. Our results with these cells could lead to new therapies for the treatment of spinal cord lesions in humans...
  89. ncbi Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function
    G S Griesbach
    David Geffen School of Medicine at UCLA, Division of Neurosurgery, Los Angeles, CA 90095 7039, USA
    Neuroscience 125:129-39. 2004
    ..However, when exercise is administered to soon after TBI, the molecular response to exercise is disrupted and recovery may be delayed...
  90. ncbi Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury
    S Okada
    Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    J Neurosci Res 76:265-76. 2004
    ..These findings suggest that neutralization of IL-6 signaling in the acute phase of SCI represents an attractive option for the treatment of SCI...
  91. pmc White matter integrity is a stronger predictor of motor function than BOLD response in patients with stroke
    Mingguo Qiu
    Third Military Medical University, Chongqing, China
    Neurorehabil Neural Repair 25:275-84. 2011
    ..This study explores the relationship between upper extremity motor function, white matter integrity, and BOLD response of cortical motor areas...
  92. ncbi A three-dimensional reconstruction plate for displaced midshaft fractures of the clavicle
    J W Shen
    Department of Orthopaedic and Traumatic Surgery Zhejiang Province TCM Hospital, Hangzhou 310006, Zheijiang Province, People s Republic of China
    J Bone Joint Surg Br 90:1495-8. 2008
    ..05). If fixation of midshaft fractures of the clavicle with a plate is indicated, a 3D reconstruction plate is better than one placed superiorly, because it is consistent with the stress distribution and shape of the clavicle...
  93. ncbi Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury
    Yukio Nishimura
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Science 318:1150-5. 2007
    ..These changes in the activation pattern of frontal motor-related areas represent an adaptive strategy for functional compensation after spinal cord injury...
  94. ncbi Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations
    Birgit Neuhuber
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Brain Res 1035:73-85. 2005
    ..To qualify MSC lots for future clinical application, such notable differences in donor or lot-lot efficacy highlight the need for establishing adequate characterization, including the development of relevant efficacy assays...
  95. ncbi Plasticity of cortical projections after stroke
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Neuroscientist 9:64-75. 2003
    ..Plasticity within cortical connections after stroke leads to partial recovery of function after the initial injury...
  96. ncbi Effects of erythropoietin on angiogenesis after myocardial infarction in porcine
    Keisuke Kawachi
    Division of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama, Kanagawa, 227 8501, Japan
    Heart Vessels 27:79-88. 2012
    ..05) compared with the controls. In conclusion, EPO accelerates angiogenesis via the upregulation of systemic levels such as HGF and FGF, and the local expression of VEGF and IGF, in porcine MI...
  97. ncbi Quality of life after stroke: the importance of a good recovery
    Francisco Javier Carod-Artal
    Department of Neurology, Sarah Hospital, The Sarah Network of Rehabilitation Hospitals, Brasilia, Brazil
    Cerebrovasc Dis 27:204-14. 2009
    ..Health-related quality of life (HRQoL) is a recognized and important outcome after stroke. An increased survival and the presence of moderate impairment in long-term stroke survivors impact their HRQoL...
  98. ncbi Functional MRI detects posterior shifts in primary sensorimotor cortex activation after stroke: evidence of local adaptive reorganization?
    R Pineiro
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, UK
    Stroke 32:1134-9. 2001
    ..Here, we have tested for potentially adaptive reorganization in the primary sensorimotor cortex...
  99. pmc Effectiveness of physiotherapy exercise following hip arthroplasty for osteoarthritis: a systematic review of clinical trials
    Catherine J Minns Lowe
    Department of Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    BMC Musculoskelet Disord 10:98. 2009
  100. pmc Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment
    Zhongwu Liu
    Neurology Research, E and R Building, Room 3056, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Stroke 39:2571-7. 2008
    ..We investigated contralesional corticospinal tract remodeling in the brain and spinal cord in rats after stroke and treatment of bone marrow stromal cells...
  101. ncbi Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranical magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke
    Naoyuki Takeuchi
    Department of Rehabilitation Medicine, Hospital of Hokkaido University, Sapporo, Japan
    J Rehabil Med 40:298-303. 2008
    ..We investigated whether 1 Hz rTMS improved the motor learning of the affected hand in patients after stroke...

Research Grants71

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..Disease/therapy</keyword;keyword>Rats</keyword;keyword>Recovery of Function</keyword;keyword>Seizures/prevention &amp;control</keyword;keyword>*Stem Cell ..
  2. Surgical Revascularization's Impact on Mitochondria in Hibernating Myocardium
    ROSEMARY FRANCES KELLY; Fiscal Year: 2013
    ..revascularization of hibernating myocardium results in a wide spectrum of outcomes from near total recovery of function to dense infarction...
  3. Cardiac Regeneration through Growth Factor Eluting Microrod Scaffolds
    Paul H Goldspink; Fiscal Year: 2013
    ..peptide from the prohormone) that is a member of the insulin-like growth factor (IGF) family and shown recovery of function in failing mouse hearts along with the mobilization of resident progenitor cells...
  4. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2013 the scaling up of a transplantation model, cats are easily trained to perform locomotor tasks, and recovery of function can be assessed by kinematic and electrophysiological measures...
  5. Suppressors of cytokine signaling (SOCS) in HAART-treated HIV infection
    Maria C Villacres; Fiscal Year: 2010
    ..factor interferon-gamma by memory CD4 T cells, indicating relative recovery of CD4 counts but poor recovery of function. Also, markers of cell inflammation are commonly observed in HIV infection...
  6. Glycemic control in pediatric critical illness: The Ped-E-Trol trial
    MARK RANSFORD RIGBY; Fiscal Year: 2011
    ..At the conclusion of this study we will determine if strict glycemic control (1) facilitates the recovery of function of select and composite organs affected by critical illness, (2) is a safe therapy without undo side ..
    Richard E Zigmond; Fiscal Year: 2010
    ..This proposal focuses on identifying molecules that trigger regeneration with the idea that they might be used to enhance regeneration in the periphery and promote regeneration in the central nervous system. ..
    Xiang Yang Chen; Fiscal Year: 2012
    ..would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  9. Translational outcome measures of cervical spinal cord injury
    JESSICA LEIGH NIELSON; Fiscal Year: 2012
    ..spinal cord injury (SCI), and efforts are underway in animal models to promote regeneration of the CST for recovery of function. However, there is a lack of standardized outcome measures in both humans and animal models (primates and ..
  10. Inflammasome regulation after spinal cord injury
    Robert W Keane; Fiscal Year: 2012 inflammation that occurs within days of SCI, and to devise therapies to treat SCI and help in long-term recovery of function. The development of new treatments that can be given in the first hours after SCI may prevent or reverse ..
  11. Reconstruction of the nigrostriatal pathway
    George M Smith; Fiscal Year: 2013
    ..This leads to incomplete recovery of function both in animal models and in human PD patients, because the transplanted neurons provide a dopamine source ..
  12. Metaplasticity and Recovery After Spinal Cord Injury: Cellular Mechanisms
    Adam R Ferguson; Fiscal Year: 2012
    ..Aim 4 tests the therapeutic potential of a TNFa1 inhibitor for promoting use-dependent plasticity and recovery of function after contusive SCI...
  13. Research Training in Rehabilitation for Brain Injury and Neurological Disability
    MICHAEL VAN DOREN JOHNSTON; Fiscal Year: 2013 to rehabilitation;3) physiology of swallowing and recovery from dysphagia;4) brain plasticity and recovery of function;5) spinal cord rehabilitation and regeneration;and 6) epidemiology and rehabilitation outcomes...
    DENNIS MICHAEL LEVI; Fiscal Year: 2012
    ..disrupted, and is thus an ideal model for understanding when and how brain plasticity may be harnessed for recovery of function. Our goal is to assess the limits and mechanisms of neural plasticity in the spatial vision of adults and ..
  15. Spinal Cord Injury, Plasticity and Transplant Mediated Repair
    John D Houle; Fiscal Year: 2013
    ..of regeneration and activity dependent plasticity after SCI, focusing on transplant-mediated effects on recovery of function and the proposition that exercise will facilitate further recovery by promoting connectivity of ..
  16. CHIP: A link between the chaperone and proteasome system
    Jonathan C Schisler; Fiscal Year: 2013 the folding, maturation, and proper subcellular targeting of nascent proteins or, conversely, the recovery of function of proteins that have been misfolded or otherwise damaged by cellular stressors...
  17. Regulation of synaptic plasticity by eCBs in adult and aged mammalian cortex
    Karen L Montey; Fiscal Year: 2012
    ..of the CB1R pathway may enhance ocular dominance plasticity in adults, providing an opportunity for recovery of function following chronic MD...
  18. Neuromodulation of Ionic Currents and Neuronal Network Activity
    JORGE P GOLOWASCH; Fiscal Year: 2013
    ..The mechanisms underlying such stabilization and recovery of function are not well known, and their understanding may be of enormous therapeutical relevance...
  19. Efficacy of Voice Treatment for Parkinson's Disease
    Lorraine O Ramig; Fiscal Year: 2011
    ..propose to continue to develop and refine our treatment model by seeking to understand the neural bases of recovery of function in IPD...
  20. Dopamine Signaling Mechanisms of Traumatic Brain Injury
    C Edward Dixon; Fiscal Year: 2013
    ..In survivors, TBI results in the persistent disturbance of cognitive functioning. This project seeks to examine key neurochemical mechanisms underlying cognitive deficits and to evaluate novel therapies to maximize recovery of function.
  21. Heart-Brain Retraining: Forced Aerobic exercise for Stroke Rehabilitation
    SUSAN MARIE LINDER; Fiscal Year: 2013
    ..goal of this study is to gather initial data regarding the potential of forced aerobic exercise to augment recovery of function in patients with stroke...
  22. Molecular mechanisms of adult neurogenesis following traumatic brain injury
    MICHELLE LEE THEUS; Fiscal Year: 2010
    ..Our ultimate goal is to devise novel experimental therapies to treat brain injury and improve recovery of function in patients who sustain head trauma using adult neural stem cells.
  23. Morphine undermines recovery of function after SCI: Neurobiological mechanisms
    Michelle A Hook; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Morphine undermines recovery of function after SCI: Deriving molecular mechanisms Project Narrative Morphine is one of the most effective and most ..
  24. The role of traumatic brain injury stress response on exercise therapy
    Grace Sophia Griesbach; Fiscal Year: 2012
    ..sustained stress is likely to decrease BDNF and downstream molecules, some forms of exercise may encumber recovery of function after TBI...
  25. Inducible Expression of Exogenous Potassium Channels in Hair Cells
    Jeffrey R Holt; Fiscal Year: 2012
    ..plasticity in a mouse model of age- related hearing and balance dysfunction, as well as during recovery of function. To generate our novel mouse model we will use a form of the bacterial Lac operator / repressor system that ..
  26. Proteases in Spinal Cord Plasticity &Regeneration
    Nicholas W Seeds; Fiscal Year: 2010
    ..from this project may lead to translational studies as a potential therapy to promote synaptic formation, re-activation and recovery of function following human spinal cord injury. 2R01 NS044129-06A2 Seeds, Nicholas
  27. A Novel Adjunct to Physical Training to Improve Motor Recovery Following Stroke
    Michael P Kilgard; Fiscal Year: 2013
    ..out the following Task: Task 1: Using a rat model of middle cerebral artery occlusion (MCAo), evaluate recovery of function of upper limb motor deficits in three groups of rats: Group 1: VNS paired with rehabilitation training, ..
  28. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2011
    ..3. Delayed activation of NMDAR may accelerate recovery of function after brain injury...
    David M Ornitz; Fiscal Year: 2013
    ..Transgenic mice that overexpress Fgf2 in cardiomyocytes have decreased infarct sizes and increased recovery of function compared to WT hearts...
  30. Is cortical reorganization following limb amputation functionally relevant and re
    Scott H Frey; Fiscal Year: 2013
    ..reorganization is reversed following hand replantation and elucidate the relevance of these changes to recovery of function. Issue A): Is recovery of function associated with re-establishing the hand map within the former hand ..
  31. Low-Voltage Nerve Electrophoresis In Vivo: Role in Peripheral Nerve Regeneration
    ROGER DALE MADISON; Fiscal Year: 2013
    ..The major key to recovery of function following nerve lesions in the peripheral nervous system is the accurate regeneration of axons to their ..
  32. Sympathetic-somatomotor coupling in human SCI
    Brian D Schmit; Fiscal Year: 2013
    ..The recovery of function requires both the improvement in the control of movement as well as in the regulation of blood flow to ..
  33. Axonal Growth Therapy for Neurological Recovery from Spinal Cord Injury and Strok
    Stephen M Strittmatter; Fiscal Year: 2010
    ..Our objective in this Project is to develop NogoReceptor protein therapy for the recovery of function by local intrathecal administration in chronic spinal cord injury...
  34. Facilitating the Recovery of Function Following Stroke: The Efficacy of Inosine
    Tara L Moore; Fiscal Year: 2013
  35. Using MaqFACS to measure facial movement deficits in monkeys
    Lisa A Parr; Fiscal Year: 2012
    ..The PD monkeys will then be given a DA agonist to reverse their symptoms and recovery of function will be assessed using the same testing and measurement procedures...
  36. Transplantation of Autologous Schwann Cells for the Repair of Segmental Periphera
    Allan D Levi; Fiscal Year: 2010
    ..Although extensive axonal regeneration can be observed extending into these grafts, recovery of function may be absent or incomplete, if the axons fail to reach their intended target...
  37. Cortical reorganization and behavioral recovery after sensory loss
    Hui Xin Qi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The prognosis for partial recovery of function after spinal cord injury (SCI) in humans and mammals appears to depend largely on the degree of sparing of ascending and descending axons...
  38. Vestibular Reflexes
    WILLIAM MICHAEL KING; Fiscal Year: 2010
    ..planned studies in the future: first, a study of hair cell regeneration and the physiology that underlies recovery of function in the vestibular system, and second, a study of central vestibular signals related to detection of linear ..
  39. A neuronal process of the error signal that drives saccade adaptation
    Yoshiko Kojima; Fiscal Year: 2013
    Project Summary/Abstract Motor adaptation is an important factor in the recovery of function following motor deficits associated with neural damage due to stroke, injury or aging...
  40. Grafting genetically-modified Schwann cells into a clinically-relevant SCI model
    CHANDLER WALKER; Fiscal Year: 2013
    ..Also, the mechanism by which GDNF mediates structural protection and repair, or, very importantly, recovery of function, remains unknown...
  41. Mechanisms of recovery following traumatic brain injury
    W Dalton Dietrich; Fiscal Year: 2013
    ..consists of investigative proposals directed at developing strategies and providing new data concerning recovery of function after TBI...
  42. Neural Representation of Features in the Human Visual Cortex
    Frank Tong; Fiscal Year: 2011
    ..may lead to effective new tools to investigate, characterize, or diagnose impairments in cortical visual function resulting from disease or injury, or methods to evaluate the cortical effects of medical treatment or recovery of function.
  43. Novel Prophylactic Pharmacotherapy in an Animal Model of Closed Head Injury
    Shawn Acheson; Fiscal Year: 2013
    ..g., progesterone) has beneficial effects on recovery of function following experimentally induced ischemia...
  44. Behavioral state development in infants
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ..week in rats has been discovered when corpus callosotomy disinhibits spontaneous cortical activity and when recovery of function after callosotomy is possible...
  45. Role of Cortex and Cerebellum in Visually-Guided Motor Behavior
    David E Vaillancourt; Fiscal Year: 2011
    ..This is the first step toward our long-term goal of using patient-specific visual feedback displays during neurological rehabilitation to facilitate brain activation and maximize recovery of function.
  46. Preclinical evaluation of IGF1 therapy for traumatic brain injury
    Kathryn E Saatman; Fiscal Year: 2013
    ..TBI produces acute neurovascular damage and cell death, resulting in early functional deficits. Recovery of function may be limited by the inability of the injured brain to adequately harness endogenous repair mechanisms...
  47. Recovering from chronic brain damage by Transcranial Direct Current Stimulation
    ..has seen an explosion in the use of invasive and non- invasive brain neuromodulation methods to increase recovery of function after localized brain damage...
  48. Marijuana: Neurobiologic Correlates of Age of Onset
    Staci A Gruber; Fiscal Year: 2013
    ..the neurobiologic impact of age of onset of MJ use in conjunction with these measures or the possibility of recovery of function following an extended period of abstinence...
  49. Optimizing the Dose of Rehabilitation After Stroke
    Carolee J Winstein; Fiscal Year: 2013
    ..Although there is now definite evidence that motor training can improve recovery of function and use for patients with moderate to mild impairments, in some cases, the gains in arm use due to therapy ..
  50. Cross-modal regulation of auditory cortex function
    Hey Kyoung Lee; Fiscal Year: 2013
    ..While cross-modal plasticity is largely beneficial to blind individuals, it hinders the recovery of function by clinical interventions...
  51. Developing an Evidence-Based Treatment Continuum for Spoken and Written Language
    PELAGIE M BEESON; Fiscal Year: 2013
    ..The research proposed here has the potential to significantly impact the planning and implementation of behavioral treatment in a manner that maximizes recovery of function.
    Beverly Roberts; Fiscal Year: 2000 these underlying mechanisms, or physical competencies, has the potential to increase the rate of recovery of function during and after hospitalization (ADL, instrumental ADL and gait)...
  53. Sensory-driven motor recovery in poorly recovered subacute stroke patients
    Lumy Sawaki; Fiscal Year: 2012
    ..of the brain to reorganize after neurologic damage has occurred and thus ultimately lead to successful recovery of function. Data from animal and human models have suggested that sensory input plays an important role in motor ..
  54. In Vivo Imaging of CNS Neurons in the Adult Zebrafish
    Ronald L Meyer; Fiscal Year: 2013
    ..Since adult fish show robust recovery of function following CNS injuries, planned future work using this model to study plasticity may provide insight into ..
  55. L1 function and sensitivity to ethanol
    DEANNA BENSON; Fiscal Year: 2009
    ..neural connectivity, and will also have relevance for mechanisms of recovery following traumatic brain injury or stroke, where many developmentally regulated molecules become re-expressed and recovery of function is impaired by ethanol.
  56. Neural Dynamics of Spoken Word Recognition
    David W Gow; Fiscal Year: 2013
    ..and integrated after unilateral focal brain damage in the 18 months following stroke, to allow the recovery of function in aphasic patients...
    Philip Liu; Fiscal Year: 1999
    ..The annual direct and indirect loss from stroke is estimated to be $25 billion. Partial recovery of function is frequently noted in stroke patients...
  58. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN LOUISE KARTJE; Fiscal Year: 2011
    ..Understanding changes in plasticity-related molecules underlying anti-Nogo-A immunotherapy given at a chronic stage of stroke could lead to improved therapeutic approaches for future clinical use. ..
  59. Identification of the endogenous ligand of SAP97 PDZ3
    Robert G Kalb; Fiscal Year: 2013
    ..Overall these studies will provide insight into a fundamental neurobiological process and may have translational implications for normal brain development as well as recovery of function after injury to the adult nervous system.
  60. Optimizing Hand Rehabilitation Post-Stroke Using Interactive Virtual Environments
    Sergei V Adamovich; Fiscal Year: 2012
    ..benefit of this study will be to provide more targeted therapeutic interventions so as to maximize recovery of function in the hemiplegic hand of patients who have had a stroke...
  61. Natural History of Muscular & Reflex Changes in Stroke
    MEHDI MIRBAGHERI; Fiscal Year: 2004
    ..the correlation of mechanical abnormalities of spastic limbs with clinical assessment of spasticity and recovery of function. To address the specific aims, a series of perturbation sequences with small amplitudes will be applied to ..
    Mark F Bear; Fiscal Year: 2010
    ..of plasticity can be (and are being) applied to devise strategies to protect juvenile synapses from deleterious effects of environmental deprivation during development, and to promote synaptic strengthening and recovery of function.
    MAXWELL MOZELL; Fiscal Year: 1999
    ..delayed functional reconnection of the epithelium to the bulb explains the long delay observed in the recovery of function relative to the epithelial recovery; and whether there is a relationship between the topography or extent ..
  64. Novel Biomarkers for Stroke Injury
    MONIKA OLI; Fiscal Year: 2005 well as provide information on precise biochemical and molecular mechanisms contributing to injury and recovery of function. We have developed a specific and sensitive biomarker for acute ischemic stroke...
  65. Two-photon calcium imaging of the effects of cortical microstimulation
    R Reid; Fiscal Year: 2009
    ..untreatable disorders, including refractory depression, obsessive-compulsive disorders, and even to promote recovery of function in stroke patients...
  66. Spinal cord injury: plasticity and recovery of function
    Barbara S Bregman; Fiscal Year: 2010
    ..We hypothesize that recovery of function after treatments to increase axonal growth following spinal cord injuries in adult rats is not only due to ..
  67. Axonal growth and guidance for nervous system repair
    George Smith; Fiscal Year: 2009
    ..10 to 20% of patients that undergo surgery to repair traumatic nerve injuries show excellent to very good recovery of function. The high incidence of failed recovery is due to the misrouting of regenerating axons to their targets...
    Itzhak Fischer; Fiscal Year: 2004
    ..phenotype following transplantation into spinal cord and test their ability to promote regeneration and recovery of function. Human MSCs are easy to obtain from a patient under local anesthesia, provide a renewal population and can ..
    NEAL BARMACK; Fiscal Year: 2003
    Partial recovery of function following a unilateral labyrinthectomy (UL), termed "vestibular compensation," has served as a model for investigations of subcellular investigations of central nervous system plasticity...
    Richard Nichols; Fiscal Year: 2004
    ..In Project 5, the manner in which abnormalities of proprioceptive pathways result in loss of coordination will be studied during locomotion and targeted reaching. ..
    JAIME VILLABLANCA; Fiscal Year: 1990
    ..we propose testing 3 intervention procedures which may enhance recovery of function and anatomical reorganization after brain injury...