host parasite relations

Summary

Summary: The interactions between two organisms, one of which lives at the expense of the other.

Top Publications

  1. ncbi Biological and biomedical implications of the co-evolution of pathogens and their hosts
    Mark E J Woolhouse
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Nat Genet 32:569-77. 2002
  2. ncbi Invasion of red blood cells by malaria parasites
    Alan F Cowman
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Cell 124:755-66. 2006
  3. ncbi Helminth parasites--masters of regulation
    Rick M Maizels
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Immunol Rev 201:89-116. 2004
  4. ncbi Coevolutionary interactions between host and parasite genotypes
    Louis Lambrechts
    Laboratoire de Parasitologie Evolutive, CNRS UMR 7103, Universite Pierre et Marie Curie, CC 237, 7 quai St Bernard, 75252 Paris Cedex 05, France
    Trends Parasitol 22:12-6. 2006
  5. ncbi A general theory for the evolutionary dynamics of virulence
    Troy Day
    Department of Mathematics, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Am Nat 163:E40-63. 2004
  6. ncbi A role for coccidian cGMP-dependent protein kinase in motility and invasion
    Helen I Wiersma
    Department of Human and Animal Infectious Disease Research, Merck Research Laboratories, Merck and Co Inc, PO Box 2000, Rahway, NJ 07065, USA
    Int J Parasitol 34:369-80. 2004
  7. ncbi Cellular responses and cytokine profiles in Ascaris lumbricoides and Trichuris trichiura infected patients
    Stefan M Geiger
    Fundacao Oswaldo Cruz, Centro de Pesquisas Rene Rachou, Laboratorio de Imunologia, Avenida Augusto de Lima 1715, 30190 002 Belo Horizonte MG, Brazil
    Parasite Immunol 24:499-509. 2002
  8. ncbi A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle
    Blandine Franke-Fayard
    Department of Parasitology, Leiden University Medical Centre, Postbus 9600 RC, The Netherlands
    Mol Biochem Parasitol 137:23-33. 2004
  9. ncbi Cooperation and competition in pathogenic bacteria
    Ashleigh S Griffin
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Nature 430:1024-7. 2004
  10. ncbi Wolbachia variability and host effects on crossing type in Culex mosquitoes
    Steven P Sinkins
    Department of Zoology, University of Oxford, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UK
    Nature 436:257-60. 2005

Detail Information

Publications228 found, 100 shown here

  1. ncbi Biological and biomedical implications of the co-evolution of pathogens and their hosts
    Mark E J Woolhouse
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Nat Genet 32:569-77. 2002
    ....
  2. ncbi Invasion of red blood cells by malaria parasites
    Alan F Cowman
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Cell 124:755-66. 2006
    ..While some Apicomplexa can invade many different host cells, the disease-associated blood-stage form of the malaria parasite is restricted to erythrocytes...
  3. ncbi Helminth parasites--masters of regulation
    Rick M Maizels
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Immunol Rev 201:89-116. 2004
    ....
  4. ncbi Coevolutionary interactions between host and parasite genotypes
    Louis Lambrechts
    Laboratoire de Parasitologie Evolutive, CNRS UMR 7103, Universite Pierre et Marie Curie, CC 237, 7 quai St Bernard, 75252 Paris Cedex 05, France
    Trends Parasitol 22:12-6. 2006
    ..Moreover, not only the traits of the infection but also the genetic correlations among these and other traits that determine fitness might be controlled by interactions between host and parasite genotypes...
  5. ncbi A general theory for the evolutionary dynamics of virulence
    Troy Day
    Department of Mathematics, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Am Nat 163:E40-63. 2004
    ..It also leads to novel predictions that are not possible using the game-theoretic approach. The general theory can be used to model the evolution of other pathogen traits as well...
  6. ncbi A role for coccidian cGMP-dependent protein kinase in motility and invasion
    Helen I Wiersma
    Department of Human and Animal Infectious Disease Research, Merck Research Laboratories, Merck and Co Inc, PO Box 2000, Rahway, NJ 07065, USA
    Int J Parasitol 34:369-80. 2004
    ..These data clearly demonstrate that cGMP-dependent protein kinase performs an important role in the host-parasite interaction...
  7. ncbi Cellular responses and cytokine profiles in Ascaris lumbricoides and Trichuris trichiura infected patients
    Stefan M Geiger
    Fundacao Oswaldo Cruz, Centro de Pesquisas Rene Rachou, Laboratorio de Imunologia, Avenida Augusto de Lima 1715, 30190 002 Belo Horizonte MG, Brazil
    Parasite Immunol 24:499-509. 2002
    ....
  8. ncbi A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle
    Blandine Franke-Fayard
    Department of Parasitology, Leiden University Medical Centre, Postbus 9600 RC, The Netherlands
    Mol Biochem Parasitol 137:23-33. 2004
    ..With the recent development of a second, independent selectable marker in P. berghei, PbGFPCON is a useful tool to investigate the effect of further genetic modifications on host-parasite interactions...
  9. ncbi Cooperation and competition in pathogenic bacteria
    Ashleigh S Griffin
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Nature 430:1024-7. 2004
    ....
  10. ncbi Wolbachia variability and host effects on crossing type in Culex mosquitoes
    Steven P Sinkins
    Department of Zoology, University of Oxford, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UK
    Nature 436:257-60. 2005
    ....
  11. ncbi Plant chemistry and natural enemy fitness: effects on herbivore and natural enemy interactions
    Paul J Ode
    Department of Entomology, North Dakota State University, Fargo, 58105, USA
    Annu Rev Entomol 51:163-85. 2006
    ..Explicit tests are required to determine whether natural enemies can act as selective forces on plant defense. Finally, further studies of natural systems are crucial to understanding the evolution of multitrophic relationships...
  12. ncbi Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host
    Jeroen P J Saeij
    Stanford University School of Medicine, Department of Microbiology and Immunology, Fairchild Building D305, 300 Pasteur Drive, Stanford, CA 94305 5124, USA
    Trends Parasitol 21:476-81. 2005
    ..Many studies have investigated the ability of T. gondii to manipulate its host but few have examined directly whether the three lineages differ in this ability...
  13. ncbi Introduced species and their missing parasites
    Mark E Torchin
    Marine Science Institute and Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, California 93106, USA
    Nature 421:628-30. 2003
    ....
  14. ncbi The role of parasites in sympatric and allopatric host diversification
    Angus Buckling
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Nature 420:496-9. 2002
    ..These results show that exploiters can drive diversification between populations, but may inhibit diversification within populations by opposing diversifying selection that arises from resource competition...
  15. ncbi The cytoskeleton and motor proteins of human schistosomes and their roles in surface maintenance and host-parasite interactions
    Malcolm K Jones
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Bioessays 26:752-65. 2004
    ..Unresolved questions in relation to the structure and function of the tegument relate to dynamic organization of the syncytial layer...
  16. ncbi Pathogenicity and virulence
    Stephen R Thomas
    Graduate Program in Organismic and Evolutionary Biology and Department of Entomology, University of Massachusetts, Amherst, MA 01003, USA
    J Invertebr Pathol 85:146-51. 2004
    ..Another common bioassay estimate is LT(50) (median time to death of infected hosts), which is a measure of virulence as long as survivors are not included in its calculation...
  17. ncbi Local adaptation in the Linum marginale-Melampsora lini host-pathogen interaction
    Peter H Thrall
    Centre for Plant Biodiversity Research, CSIRO Plant Industry, Canberra ACT, Australia
    Evolution 56:1340-51. 2002
    ..We argue that this is unlikely to be the case in the metapopulation situations that predominate in natural host-pathogen interactions, thus requiring tests that control simultaneously for variation in plant and pathogen populations...
  18. pmc Age-specific interaction between the parasitoid, Encarsia formosa and its host, the silverleaf whitefly, Bemisia tabaci (Strain B)
    Jing S Hu
    Insect Biocontrol Laboratory, USDA, ARS, PSI, Beltsville, MD 20705, USA
    J Insect Sci 3:28. 2003
    ..formosa, and provide possible explanations for why T. vaporariorum is a more suitable host than B. tabaci for E. formosa...
  19. ncbi Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites
    Theodore F Taraschi
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    Blood 102:3420-6. 2003
    ..It is proposed that the parasite adapted a process well established for intracellular transport to mediate the extracellular movement of its proteins through the erythrocyte cytosol to the surface membrane...
  20. ncbi The effects of host immunity on virulence-transmissibility relationships in the rodent malaria parasite Plasmodium chabaudi
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
    Parasitology 126:103-12. 2003
    ..These results support the basic assumption underlying our theory that predicts that anti-disease vaccines will select for higher virulence in those microparasites for which virulence is integrally linked to transmission...
  21. pmc The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells
    Ian J Glomski
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Cell Biol 156:1029-38. 2002
    ....
  22. ncbi Do trematode parasites disrupt defence-cell signalling in their snail hosts?
    Anthony J Walker
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey, UK, KT1 2EE
    Trends Parasitol 22:154-9. 2006
    ..The hypothesis is that, to facilitate survival and replication in their intermediate hosts, trematode parasites down regulate host defence responses by interfering with key signal-transduction pathways in snail defence cells...
  23. ncbi Could insecticide-treated cattle reduce Afrotropical malaria transmission? Effects of deltamethrin-treated Zebu on Anopheles arabiensis behaviour and survival in Ethiopia
    T Habtewold
    FARM Africa, Southampton Place, London, UK
    Med Vet Entomol 18:408-17. 2004
    ..arabiensis populations or their vectorial capacity. Even so, it seems likely that far greater impact on anopheline mosquitoes could be achieved by applying insecticide selectively to the legs of cattle...
  24. ncbi Conservation of epidermal growth factor receptor function in the human parasitic helminth Schistosoma mansoni
    Jerome Vicogne
    Unité 547 INSERM, Institut Pasteur de Lille, 59019 Lille Cedex, France
    J Biol Chem 279:37407-14. 2004
    ..The possible role of SER as a receptor for host EGF peptides and its implication in host-parasite signaling and parasite development are discussed...
  25. ncbi Feedback with soil biota contributes to plant rarity and invasiveness in communities
    John N Klironomos
    Department of Botany, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Nature 417:67-70. 2002
    ..These results indicate that plants have different abilities to influence their abundance by changing the structure of their soil communities, and that this is an important regulator of plant community structure...
  26. ncbi A worm's eye view of the immune system: consequences for evolution of human autoimmune disease
    David W Dunne
    Department of Pathology, University of Cambridge, Cambridge, UK
    Nat Rev Immunol 5:420-6. 2005
    ..As we discuss here, this is a marked perturbation, and the absence of the associated immunomodulation might have led to the increased emergence of autoimmune diseases...
  27. ncbi Evolution of multihost parasites
    Sylvain Gandon
    Génétique et Evolution des Maladies Infectieuses, UMR CNRS IRD 2724, Institut de Recherche pour le Developpement, 911 Avenue Agropolis, 34394 Montpellier 5, France
    Evolution 58:455-69. 2004
    ..Because many of the pathogens that have large public-health and agricultural impacts have complex life cycles, an understanding of their evolutionary dynamics could hold substantial benefits for management...
  28. ncbi Wolbachia effects in Drosophila melanogaster: in search of fitness benefits
    W Harcombe
    Section of Integrative Biology, University of Texas at Austin, TX 78712, USA
    J Invertebr Pathol 87:45-50. 2004
    ..The absence of nutrition or stress effects suggests that other processes maintain wMel frequencies in natural populations of Drosophila melanogaster...
  29. ncbi Mosquito midguts and malaria: cell biology, compartmentalization and immunology
    M M A Whitten
    Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Parasite Immunol 28:121-30. 2006
    ..Here we discuss recent advances in genomic analyses, coupled with detailed microscopical investigations, which are helping to unravel the identity and roles of the major players of these complex systems...
  30. ncbi The role of evolution in the emergence of infectious diseases
    Rustom Antia
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Nature 426:658-61. 2003
    ..Here we show that, as a consequence of this, the probability of pathogen evolution to R(0) > 1 and subsequent disease emergence can increase markedly...
  31. ncbi Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature
    Timothy J Dowse
    Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, UK, SW7 2AZ
    Trends Parasitol 21:254-8. 2005
    ..In this article, we present the current repertoire of rhomboid-like proteins in Apicomplexa using a nomenclature based on phylogenetic analyses...
  32. ncbi Mosquito--malaria interactions: a reappraisal of the concepts of susceptibility and refractoriness
    R E Sinden
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK
    Insect Biochem Mol Biol 34:625-9. 2004
    ....
  33. ncbi Emergence/re-emergence of Echinococcus spp.--a global update
    D J Jenkins
    Australian Hydatid Control and Epidemiology Program, 12 Mildura Street, Fyshwick, ACT 2609, Australia
    Int J Parasitol 35:1205-19. 2005
    ..The review also refers to the transmission pattern of a recently described new species, Echinococcus shiquicus, from China...
  34. ncbi Immune responses in Anopheles gambiae
    Elena A Levashina
    UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg CEDEX, France
    Insect Biochem Mol Biol 34:673-8. 2004
    ..In this review, we will summarize our present knowledge of immune responses in the mosquito Anopheles gambiae and attempt a comparative analysis of insect immune systems...
  35. ncbi Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial
    Robert W Summers
    James A Clifton Center for Digestive Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Gastroenterology 128:825-32. 2005
    ..In animal models, helminths prevent or improve colitis by the induction of regulatory T cells and modulatory cytokines. This study determined the efficacy and safety of the helminth Trichuris suis in therapy of ulcerative colitis...
  36. ncbi Identification of transcripts generated during the response of resistant Biomphalaria glabrata to Schistosoma mansoni infection using suppression subtractive hybridization
    Thomas S Nowak
    Department of Biology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Parasitol 90:1034-40. 2004
    ..mansoni by B. glabrata and identifies a series of transcripts deserving additional study in comparing susceptible and resistant snails...
  37. pmc Two separate growth phases during the development of Leishmania in sand flies: implications for understanding the life cycle
    Sharon M Gossage
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Int J Parasitol 33:1027-34. 2003
    ..A new scheme for the life cycle in the subgenus Leishmania (Leishmania) is proposed that incorporates these findings...
  38. ncbi Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population
    Oumou Niare
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
    Science 298:213-6. 2002
    ..The apparently high natural frequency of resistance alleles suggests that malaria parasites (or a similar pathogen) exert a significant selective pressure on vector populations...
  39. ncbi How do malaria ookinetes cross the mosquito midgut wall?
    Luke A Baton
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Trends Parasitol 21:22-8. 2005
    ..We also propose a novel hypothesis, the Cellular Treadmill model, to explain the movement of ookinetes through multiple adjacent midgut cells...
  40. pmc SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites and infected erythrocytes
    Gerhard Winter
    Microbiology and Tumorbiology Center, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Exp Med 201:1853-63. 2005
    ..By exposing shared polymorphic antigens on IEs and merozoites, the parasite may coordinate the antigenic composition of these attachment surfaces during growth in the bloodstream...
  41. ncbi Mechanisms underlying the manipulation of host apoptotic pathways by Toxoplasma gondii
    A P Sinai
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose St, Lexington, KY 40536, USA
    Int J Parasitol 34:381-91. 2004
    ..The implications of these observations extend beyond Toxoplasma biology to the broader area of microbial pathogenesis and cell signalling in mammalian cells...
  42. ncbi The effect of migration on local adaptation in a coevolving host-parasite system
    Andrew D Morgan
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Nature 437:253-6. 2005
    ..However, in accord with our model, parasite migration results in parasite local adaptation, but host migration alone has no significant effect...
  43. ncbi Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite
    Junitsu Ito
    Case Western Reserve University, Department of Genetics, 10900 Euclid Avenue, Ohio 44106 4955, USA
    Nature 417:452-5. 2002
    ..These findings have significant implications for the development of new strategies for malaria control...
  44. ncbi Plasmodium falciparum ookinete invasion of the midgut epithelium of Anopheles stephensi is consistent with the Time Bomb model
    L A Baton
    Institute of Biomedical and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
    Parasitology 129:663-76. 2004
    ....
  45. ncbi Patterns of host specificity and transmission among parasites of wild primates
    Amy B Pedersen
    Department of Biology, University of Virginia, Charlottesville, 22904, USA
    Int J Parasitol 35:647-57. 2005
    ..Furthermore, nearly all viruses that were reported to infect both humans and non-human primates were classified as emerging in humans...
  46. pmc Analysis of ESTs from Lutzomyia longipalpis sand flies and their contribution toward understanding the insect-parasite relationship
    Rod J Dillon
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Genomics 88:831-40. 2006
    ..Sequence analysis of this transcriptome dataset has provided new insights into genes that might be associated with the response of the vector to the development of Leishmania...
  47. ncbi Defence against multiple enemies
    K Poitrineau
    Génétique et Environnement, ISEM, Universite Montpellier II, Montpellier 5, France
    J Evol Biol 16:1319-27. 2003
    ..We discuss possible implications of the existence of multiple enemies for conservation biology, biological control and chemical control...
  48. ncbi Support vector machines for separation of mixed plant-pathogen EST collections based on codon usage
    Caroline C Friedel
    Institut fuer Informatik, Ludwig Maximilians Universitaet Muenchen, Oettingenstrasse 67, 80538 Muenchen, Germany
    Bioinformatics 21:1383-8. 2005
    ..When using single-pass cDNA sequences difficulties arise from the short sequence length, the lack of sufficient taxonomically relevant sequence data in public databases and ambiguous sequence homology between plant and pathogen genes...
  49. ncbi Regulation of Wolbachia density in the Mediterranean flour moth, Ephestia kuehniella, and the almond moth, Cadra cautella
    Takashi Ikeda
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Japan
    Zoolog Sci 20:153-7. 2003
    ..The density of each Wolbachia variant did not differ significantly between the singly and doubly transfected hosts, suggesting independent regulation...
  50. ncbi The population genetics of host specificity: genetic differentiation in dove lice (Insecta: Phthiraptera)
    Kevin P Johnson
    Illinois Natural History Survey, Champaign, IL 61820, USA
    Mol Ecol 11:25-38. 2002
    ..Underlying differences in dispersal biology probably explain the differences in population genetic structure that we observed between Columbicola and Physconelloides...
  51. ncbi Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites
    Travis J Jewett
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Mol Cell 11:885-94. 2003
    ..Our findings reveal a potential role for aldolase in connecting TRAP family adhesins with the cytoskeleton, and provide a model linking adhesion with motility in apicomplexan parasites...
  52. ncbi 'The glideosome': a dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii
    Corinna Opitz
    Robert Koch Institut, Berlin, Germany
    Mol Microbiol 45:597-604. 2002
    ..Together with F-actin and as yet unknown bridging molecules and proteases, these complexes are among the structural and functional components of the 'glideosome'...
  53. pmc Calcium signaling in a low calcium environment: how the intracellular malaria parasite solves the problem
    Marcos L Gazarini
    Department of Physiology, Institute of Biosciences, University of Sao Paulo, Sao Paulo 05508 900, Brazil
    J Cell Biol 161:103-10. 2003
    ....
  54. ncbi Why is the effect of malaria parasites on mosquito survival still unresolved?
    Heather M Ferguson
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Trends Parasitol 18:256-61. 2002
    ..However, mortality effects are more likely to be detected in unnatural vector-parasite combinations and in studies of longer duration. Until these factors are systematically investigated, no firm generalities are possible...
  55. ncbi A role for insect galectins in parasite survival
    Shaden Kamhawi
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Cell 119:329-41. 2004
    ..In addition, these studies demonstrate the feasibility of using midgut receptors for parasite ligands as target antigens for transmission-blocking vaccines...
  56. ncbi Insect immunity and its implication in mosquito-malaria interactions
    George Dimopoulos
    Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College of Science, Technology and Medicine, SW7 2AZ London, UK
    Cell Microbiol 5:3-14. 2003
    ....
  57. ncbi Comparing host and parasite phylogenies: gyrodactylus flatworms jumping from goby to goby
    Tine Huyse
    Katholieke Universiteit Leuven, Laboratory of Aquatic Ecology, Ch De Beriotstraat 32, Leuven B 3000, Belgium
    Syst Biol 54:710-8. 2005
    ..This illustrates that phylogenetically conserved host-switching mimics the phylogenetic signature of co-speciation, confounding topology-based programs...
  58. pmc The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity
    Daniel A Portnoy
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    J Cell Biol 158:409-14. 2002
    ..Alteration in any of these processes dramatically reduces the ability of the bacteria to establish a productive infection in vivo...
  59. ncbi Immune regulation by helminth parasites: cellular and molecular mechanisms
    Rick M Maizels
    Institute for Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Immunol 3:733-44. 2003
    ..Long-lived parasites such as the helminths, however, are more remarkable for their ability to downregulate host immunity, protecting themselves from elimination and minimizing severe pathology in the host...
  60. pmc Survival of Wolbachia pipientis in cell-free medium
    Jason L Rasgon
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, E4626, Baltimore, MD 21205, USA
    Appl Environ Microbiol 72:6934-7. 2006
    ..Our development of methods to purify and maintain viable Wolbachia bacteria from cultured cells will be useful for other researchers studying Wolbachia biology...
  61. ncbi Gene expression profiling of Arabidopsis thaliana in compatible plant-aphid interactions
    Patrick J Moran
    Center for Insect Science, University of Arizona, Tucson, USA
    Arch Insect Biochem Physiol 51:182-203. 2002
    ..The establishment of links between insect elicitation, plant signaling associated with phloem feeding, and proximal resistance mechanisms is critical to further research progress in this area...
  62. ncbi Spatial heterogeneity and the stability of host-parasite coexistence
    M A Brockhurst
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, UK
    J Evol Biol 19:374-9. 2006
    ..These results suggest that spatial heterogeneity can stabilize an otherwise unstable host-parasite interaction even in the absence of permanent spatial refuges...
  63. ncbi Virulence in rodent malaria: host genotype by parasite genotype interactions
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, Scotland EH9 3JT, UK
    Infect Genet Evol 1:287-96. 2002
    ..Both mortality and morbidity-related factors might therefore influence the upper limit on virulence of malaria parasites...
  64. pmc Midgut epithelial responses of different mosquito-Plasmodium combinations: the actin cone zipper repair mechanism in Aedes aegypti
    Lalita Gupta
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Proc Natl Acad Sci U S A 102:4010-5. 2005
    ..The implications of these observations to validate animal experimental systems that reflect the biology of natural vectors of human malarias are discussed...
  65. pmc Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes
    Jude M Przyborski
    Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Heidelberg, Germany
    EMBO J 24:2306-17. 2005
    ..Our data suggest general principles for transport of transmembrane proteins to the Maurer's clefts and provide new insights into protein sorting and trafficking processes in P. falciparum...
  66. ncbi Does multiple infection select for raised virulence?
    Sam P Brown
    Génétique et Environnement, ISEM, University of Montpellier II, Place Eugene Bataillon, 34095, Montpellier, France
    Trends Microbiol 10:401-5. 2002
    ..We illustrate that, depending on the mechanistic details of exploitation, multiple infection can select for reduced virulence...
  67. ncbi Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases
    Agnidipta Ghosh
    Department of Structural Biology, Max Planck Institute for Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Mol Cell 15:727-39. 2004
    ....
  68. pmc Bacteriocins, spite and virulence
    Andy Gardner
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 271:1529-35. 2004
    ..This emphasizes how biological details can fundamentally alter the qualitative nature of theoretical predictions made by models of parasite virulence...
  69. pmc A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma
    Fabien Brossier
    Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Proc Natl Acad Sci U S A 102:4146-51. 2005
    ..T. gondii rhomboids have clear homologues in other apicomplexans including malaria; thus, our findings provide a model for studying invasion by this deadly pathogen and offer a target for therapeutic intervention...
  70. pmc The effect of spatial heterogeneity and parasites on the evolution of host diversity
    Michael A Brockhurst
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Proc Biol Sci 271:107-11. 2004
    ..Such interactions between key ecological variables need to be considered when addressing diversification and coexistence in future studies...
  71. ncbi Population genetics of multi-host parasites--the case for molecular epidemiological studies of Schistosoma japonicum using larval stages from naturally infected hosts
    J Shrivastava
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College St Mary s Hospital Campus, Norfolk Place, London W2 1PG, UK
    Parasitology 131:617-26. 2005
    ..Our results thus advocate the use of natural life-cycle stages to obtain an accurate and ethical representation of the population genetic structure of S. japonicum and other multi-host pathogens...
  72. ncbi When mutualists are pathogens: an experimental study of the symbioses between Steinernema (entomopathogenic nematodes) and Xenorhabdus (bacteria)
    M Sicard
    Laboratoire Genome, Populations, Interactions, Adaptation, Universite de Montpellier II, Montpellier, France
    J Evol Biol 17:985-93. 2004
    ..The pathogenicity of some non-native bacterial strains against S. carpocapsae could result from the incapacity of the nematode to resist specific virulence factors produced by these bacteria...
  73. ncbi Behavioural and electrophysiological responses of the malaria mosquito Anopheles gambiae Giles sensu stricto (Diptera: Culicidae) to human skin emanations
    Y T Qiu
    Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands
    Med Vet Entomol 18:429-38. 2004
    ..Glass beads provide a suitable neutral substrate for the transfer of human odour to enable chemical analysis of the human skin emanations for identification of kairomones of anthropophilic mosquitoes...
  74. ncbi A proteomic analysis of malaria biology: integration of old literature and new technologies
    R E Sinden
    Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road, London SW7 2AZ, UK
    Int J Parasitol 34:1441-50. 2004
    ..When viewed together, the old and new data can give rapid and penetrating insights into what some might now term the 'Systems-Biology' of Plasmodium...
  75. ncbi Protein and lipid trafficking induced in erythrocytes infected by malaria parasites
    Kasturi Haldar
    Department of Pathology, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Cell Microbiol 4:383-95. 2002
    ..Further multiple exported proteins transit through secretory 'cleft' structures, suggesting that clefts may be sorting compartments assembled by the parasite in the red cell...
  76. ncbi Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation
    Aaron M Woolsey
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Cell Sci 116:3611-22. 2003
    ..Jointly, these data provide a new paradigm for T. cruzi invasion of non-professional phagocytic cells and reveal a novel vacuole maturation process that appears to bypass the requirement for EEA1...
  77. ncbi Close association of invading Plasmodium berghei and beta integrin in the Anopheles gambiae midgut
    Vasso Mahairaki
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Crete, Greece
    Arch Insect Biochem Physiol 60:13-9. 2005
    ..This intimate association suggests a specific role of beta integrin in the invasion process...
  78. ncbi The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels
    Wade Spear
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cell Microbiol 8:339-52. 2006
    ..These data indicate that Toxoplasma activates HIF1 and requires HIF1 for growth and survival at physiologically relevant oxygen levels...
  79. ncbi Real-time, in vivo analysis of malaria ookinete locomotion and mosquito midgut invasion
    Dina Vlachou
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell Microbiol 6:671-85. 2004
    ..Similar observations were made in both A. gambiae and A. stephensi, demonstrating the conservation of P. berghei interactions with these vectors...
  80. pmc Host-parasite interactions and the evolution of ploidy
    Scott L Nuismer
    Department of Biological Sciences, University of Idaho, Moscow, 83844, USA
    Proc Natl Acad Sci U S A 101:11036-9. 2004
    ..These results are consistent with the predominance of haploidy among parasitic protists...
  81. pmc Molecular interactions between the specialist herbivore Manduca sexta (lepidoptera, sphingidae) and its natural host Nicotiana attenuata: V. microarray analysis and further characterization of large-scale changes in herbivore-induced mRNAs
    Dequan Hui
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Plant Physiol 131:1877-93. 2003
    ....
  82. ncbi Parasitism increases and decreases the costs of insecticide resistance in mosquitoes
    Philip Agnew
    Centre d Etudes sur le Polymorphisme des Microorganismes, Unité Mixte de Recherche 9926, Centre National de la Recherche Scientifique Institut de Recherche pour le Développement, 911 Avenue Agropolis, BP 64501, 34394 Montpellier 5, France
    Evolution 58:579-86. 2004
    ....
  83. ncbi Fitness of indirectly transmitted pathogens: restraint and constraint
    Charlotte M Gower
    Peter Medawar Building for Pathogen Research, and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom
    Evolution 58:1178-84. 2004
    ....
  84. ncbi Release of invasive plants from fungal and viral pathogens
    Charles E Mitchell
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 421:625-7. 2003
    ..Our results indicate that invasive plants' impacts may be a function of both release from and accumulation of natural enemies, including pathogens...
  85. ncbi Wolbachia replication and host cell division in Aedes albopictus
    Toon Ruang-areerate
    Center for Vectors and Vector Borne Diseases and Department of Biology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Curr Microbiol 49:10-2. 2004
    ..We have shown that Wolbachia densities in eggs are greatest during embryonation and then decline throughout diapause, suggesting that Wolbachia replication is dependent on host cell replication...
  86. ncbi In vivo imaging of malaria parasites--recent advances and future directions
    Rogerio Amino
    Unité de Biologie et Génétique du Paludisme and Grand Programme Horizontal Anopheles, Institut Pasteur, 25 28 Rue du Dr Roux, 75015 Paris, France
    Curr Opin Microbiol 8:407-14. 2005
    ..Similar analysis with Plasmodium sporozoites has revealed the importance of parasite motility in transmission from the mosquito vector to the mammalian host...
  87. ncbi When do parasites fail to speciate in response to host speciation?
    Kevin P Johnson
    Illinois Natural History Survey, 607 East Peabody Drive, Champaign, Illinois 61820, USA
    Syst Biol 52:37-47. 2003
    ..Relative rate comparisons for the mitochondrial cytochrome oxidase I gene indicate that molecular substitution occurs about 11 times faster in lice than in their avian hosts...
  88. ncbi New insights into the developmental biology and transmission mechanisms of Leishmania
    P A Bates
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Curr Mol Med 4:601-9. 2004
    ..Leptomonad forms also produce promastigote secretory gel, a substance that plays a key role in transmission by forming a physical obstruction in the gut, forcing the sandfly to regurgitate metacyclic promastigotes during bloodfeeding...
  89. ncbi Myosin A tail domain interacting protein (MTIP) localizes to the inner membrane complex of Plasmodium sporozoites
    Lawrence W Bergman
    Division of Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Cell Sci 116:39-49. 2003
    ..The actin/TRAP complex is then redistributed by the stationary MyoA from the anterior to the posterior end of the zoite, leading to its forward movement on a substrate or to penetration of a host cell...
  90. ncbi Effect of temperature on Wolbachia density and impact on cytoplasmic incompatibility
    L Mouton
    Laboratoire de Biometrie et Biologie Evolutive, UMR CNRS 5558, Universite Lyon 1, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    Parasitology 132:49-56. 2006
    ....
  91. ncbi Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii
    Peter J Bradley
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:34245-58. 2005
    ....
  92. ncbi Erythrocyte variants and the nature of their malaria protective effect
    Gundula Min-Oo
    Department of Biochemistry, McGill University, 3655 Sir William Olsler Promenade, Room 907, Montreal, QC, Canada, H3G 1Y6
    Cell Microbiol 7:753-63. 2005
    ..The recent addition of erythrocyte pyruvate kinase to this group of protective genes will also be discussed...
  93. ncbi The willow bud galler Euura mucronata Hartig (Hymenoptera: Tenthredinidae): one polyphage or many monophages?
    T Nyman
    Department of Biology, University of Joensuu, PO Box 111, FIN 80101 Joensuu, Finland
    Heredity (Edinb) 88:288-95. 2002
    ..Consequently, it is possible that reasons such as differences in host phenology, habitat, or morphology, are responsible for the limits in host use in the group...
  94. ncbi Gene discovery and expression analysis of immune-relevant genes from Biomphalaria glabrata hemocytes
    G Mitta
    Parasitologie fonctionnelle et Evolutive UMR 5555, CNRS Université de Perpignan 52 Ave Paul Alduy, 66 860 Perpignan Cedex, France
    Dev Comp Immunol 29:393-407. 2005
    ..Real-time PCR analysis of expression ratios at 7 time-points post-exposure revealed both (i) genes displaying constitutive expression differences between the two strains; and (ii) genes differentially modulated after parasite exposure...
  95. pmc Molecular interactions between the specialist herbivore Manduca sexta (lepidoptera, sphingidae) and its natural host Nicotiana attenuata. VI. Microarray analysis reveals that most herbivore-specific transcriptional changes are mediated by fatty acid-amino
    Rayko Halitschke
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Plant Physiol 131:1894-902. 2003
    ..These results demonstrate that the two most abundant FACs in Manduca spp. R can account for the majority of Manduca spp.-induced alterations of the wound response of N. attenuata...
  96. ncbi Gene flow and the coevolution of parasite range
    Scott L Nuismer
    1 University Station C0930, University of Texas, Austin, Texas 78712, USA
    Evolution 57:746-54. 2003
    ..As a consequence, reciprocal adaptation between host and parasite can become uncoupled from the rate of host gene flow...
  97. pmc Developmental plasticity in schistosomes and other helminths
    Stephen J Davies
    Tropical Disease Research Unit, Department of Pathology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Int J Parasitol 33:1277-84. 2003
    ..Further work is needed to determine whether developmental plasticity plays any role in increasing the probability of schistosome transmission and life cycle propagation under adverse conditions, as it does in other helminth life cycles...
  98. pmc Adult midgut expressed sequence tags from the tsetse fly Glossina morsitans morsitans and expression analysis of putative immune response genes
    M J Lehane
    School of Biological Sciences, University of Wales, Bangor, LL57 2UW, UK
    Genome Biol 4:R63. 2003
    ..We have undertaken an expressed sequence tag (EST) project on the adult tsetse midgut, the major organ system for establishment and early development of trypanosomes...
  99. ncbi Ookinete-induced midgut peroxidases detonate the time bomb in anopheline mosquitoes
    Sanjeev Kumar
    Laboratory of Malaria and Vector Research, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA
    Insect Biochem Mol Biol 35:721-7. 2005
    ....
  100. pmc Interspecific competition between entomopathogenic nematodes (Steinernema) is modified by their bacterial symbionts (Xenorhabdus)
    Mathieu Sicard
    Laboratoire Genome, Populations, Interactions, Adaptation UMR 5171 CNRS, Université de Montpellier 2, Place Eugène Bataillon cc, 63, 34095 Montpellier, France
    BMC Evol Biol 6:68. 2006
    ..e. naturally associated with their symbionts) of both species...
  101. ncbi Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource
    Wei Hu
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Nat Genet 35:139-47. 2003
    ....

Research Grants62

  1. Microarray analysis of gene expresion in T. cruzi
    Rick Tarleton; Fiscal Year: 2006
    ..Completion of this study will provide valuable data on the expression of genes in T. cruzi, especially the many that are "hypothetical," and provide a starting point for elucidating the functions of these genes. ..
  2. Intraspecies Transmission and Infectivity of Insectivore-Borne Hantaviruses
    Richard Yanagihara; Fiscal Year: 2011
    ..New knowledge about the shrew-borne hantaviruses will better prepare us to diagnose future outbreaks of hantavirus diseases. ..
  3. Secretion, protein targeting, and lipid metabolism in African Trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..These studies will broaden our knowledge of basic cell biological processes in all eukaryotes, and will lay the groundwork for targeting the sphingolipid pathway for novel drug development. ..
  4. Epidemiology of Dental Caries and Immunity in Children
    Noel K Childers; Fiscal Year: 2013
    ..The established community links in this underserved population will be critical for the continuation of this study as well as our understanding of gaps in dental health care in this high risk population. ..
  5. TRAINING IN MECHANISMS OF PARASITISM
    Mary E Wilson; Fiscal Year: 2013
    ..Our goal is to creatively and continually improve the environment and opportunities for trainees working on different aspects of the host-microbe balance during microbial infection. ..
  6. Plasmodium induced new permeation pathways during hepatocyte infection
    John B Sacci; Fiscal Year: 2010
    ..This could provide a novel approach for the prophylaxis and treatment of malaria. ..
  7. Host and Parasite Determinants in Human Leishmaniasis
    Edgar M Carvalho; Fiscal Year: 2013
    ..abstract_text> ..
  8. Iron acquistion in Bordetella pertussis
    SANDRA ARMSTRONG; Fiscal Year: 2003
    ..abstract_text> ..
  9. TRICHINELLOSIS AND REGULATION OF HOST GENE EXPRESSION
    Douglas Jasmer; Fiscal Year: 2001
    ..Understanding these mechanisms may also contribute unique insight on mechanisms of muscle differentiation and cell cycle regulation in mammalian cells. ..
  10. IMMUNOLOGIC RESPONSES TO SCHISTOSOMA MANSONI
    DANIEL COLLEY; Fiscal Year: 1992
    ..These settings parallel schistosomiasis in the sense that in each the body's immune system must "learn" to deal with chronic antigenic exposure...
  11. GENETIC ANALYSIS OF H. INFLUENZAE CAPSULE EXPRESSION
    SUSAN HOISETH; Fiscal Year: 1992
    ..This should allow me to construct the isogenic strains necessary to address the issue of why type b strains are more virulent than the other capsule types...
  12. RICKETTSIA-INDUCED TRANSCRIPTIONAL ACTIVATION
    SANJEEV SAHNI; Fiscal Year: 2002
    ..abstract_text> ..
  13. PARASITIC DISEASES RESEARCH IN AFRICA
    James Kazura; Fiscal Year: 1999
    ..S.-based and Kenyan-based investigators. It will provide information necessary to shape control strategies and further opportunities for training and technology transfer. ..
  14. Autophagic Defense Against Intracellular Parasites
    George Yap; Fiscal Year: 2009
    ..In this NIH exploratory proposal, our studies will yield important information how the immune response is regulated and can be manipulated to promote this type of anti-parasite host defense. ..
  15. IMMUNOBIOLOGY OF CHAGAS' DISEASE
    RAYMOND KUHN; Fiscal Year: 1991
    ..cruzi as recent results suggest that the significance of antibody in immunity to T. cruzi is highly dependent on the strain of parasite used in such studies...
  16. MACROPHAGE ACTIVATION IN AFRICAN TRYPANOSOMIASIS
    DONNA PAULNOCK; Fiscal Year: 2006
    ..The ultimate goal is to uncover novel regulatory mechanisms associated with macrophage activation that can be exploited to provide greater resistance to disease. ..
  17. IMMUNOREGULATORY T CELLS IN PULMONARY TUBERCULOSIS
    David McMurray; Fiscal Year: 1992
    ..The influence of anti-mycobacterial antibodies and immune complexes containing IgG on the functions of T-gamma cells will be determined both in vitro and in vivo...
  18. Modulation of innate immunity by microbial factors
    DONNA PAULNOCK; Fiscal Year: 2006
    ..The ultimate goal is to uncover novel regulatory mechanisms associated with macrophage activation that can be exploited to provide greater resistance to disease. ..
  19. CATECHOLAMINE REGULATION OF MACROPHAGE FUNCTION
    BRUCE ZWILLING; Fiscal Year: 2002
    ....
  20. MECHANISMS CONTROLLING NOCARDIAL PATHOGENESIS
    Blaine Beaman; Fiscal Year: 1980
    ..I shall explore the effect of the host as well as the environment on these components in order to determine how they affect the host-parasite relationship and host immunity. ..
  21. Role of CCL2/MCP-1 in mucosal immunity to Toxoplasma
    ERIC DENKERS; Fiscal Year: 2008
    ..This project will enhance our understanding of immunity to the parasite, leading to improved treatment strategies. [unreadable] [unreadable] [unreadable]..
  22. ROLE OF NEUTROPHILS DURING TOXOPLASMOSIS
    ERIC DENKERS; Fiscal Year: 2008
    ..Understanding how immunity is triggered can be expected to lead to more effective means of controlling infection with Toxoplasma and other microbial pathogens. ..
  23. Immunobiology of Parasitic Diseases
    ERIC DENKERS; Fiscal Year: 2005
    ..Existing support for the program is substantial in the form of research environment and facilities, the Cornell Biotechnology Program and computing and library systems ..
  24. Ninth International Congress on Toxoplasmosis
    Boris Striepen; Fiscal Year: 2007
    ..gondii that is not often seen in fields as high paced and[unreadable] competitive and has facilitated rapid and sustained progress in research on this pathogen[unreadable] and related parasites. ..
  25. Drug resistance in Plasmodium falciparum
    Johanna Daily; Fiscal Year: 2007
    ..abstract_text> ..
  26. IMPDH as a Drug Target in Cryptosporidium
    Boris Striepen; Fiscal Year: 2008
    ..This work will provide urgently needed molecular reagents to understand the biology of nutrient uptake and drug resistance in this unique parasite. [unreadable] [unreadable] [unreadable]..
  27. Vector Population Modification Using Wolbachia Symbionts
    Stephen Dobson; Fiscal Year: 2006
    ..g., maternal transmission rates and Wolbachia effects on host fitness), simplifying discrimination between Culex infection types, and improving methods for field cage evaluation of Wolbachia control strategies. ..
  28. Protein targeting and secretion in Toxoplasma
    Boris Striepen; Fiscal Year: 2004
    ..Mutant analysis will also provide critical information towards the function of the individual secretory organelles involved. ..
  29. Adherence of malaria-infected red cells
    Alan Cowman; Fiscal Year: 2009
    ..These studies will contribute to and increased understanding of the pathophysiology of falciparum malaria. ..
  30. REACTIVE OXYGEN SPECIES AND DROSOPHILA IMMUNITY
    A Nappi; Fiscal Year: 2001
    ..abstract_text> ..
  31. Development of a chimeric mouse model for the analysis of Plasmodium liver stages
    John Sacci; Fiscal Year: 2007
    ..This will then produce a truly comprehensive picture of gene expression during the lifecycle of human malaria parasites. [unreadable] [unreadable]..
  32. Eradication of a Primary Filariasis Vector Population at an Endemic Field Site
    STEPHEN LEONARD DOBSON; Fiscal Year: 2010
    ..Integration of the vector eradication strategy and the MDA approach will facilitate filariasis elimination in areas where MDA alone has failed. ..
  33. Global GAS Vaccine Based On The M-Protein
    Michael Good; Fiscal Year: 2008
    ..abstract_text> ..
  34. Species-specific regulated transposition in mosquitoes
    Anthony James; Fiscal Year: 2008
    ..gambiae and Ae. aegypti. ..
  35. Vesicle targeting in Plasmodium falciparum
    Julian Rayner; Fiscal Year: 2008
    ..By focusing on elements of P. falciparum secretion that are unique to this organism, we aim to identify targets for the future development of novel prevention and control measures. [unreadable] [unreadable] [unreadable]..
  36. VARIABLE GENE DEFECTS AND PNEUMOCOCCAL SUSCEPTIBILITY
    Liise Anne Pirofski; Fiscal Year: 2010
    ..The proposed studies will advance our understanding of how pneumococcal vaccine works. ..
  37. Innate Immune Receptors for Toxoplasma gondii
    Ricardo Gazzinelli; Fiscal Year: 2010
    ....
  38. Physiological response of Escherichia coli to temperature and desiccation stress
    SUSAN BORNSTEINFORST; Fiscal Year: 2008
    ..coli die-off will be important for interpreting monitoring results of beaches and discerning whether elevated E. coli levels reflect human health risk. [unreadable] [unreadable] [unreadable] [unreadable]..
  39. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
  40. Collaborative Development of a Vaccine against Cutaneous and Visceral Leishmanias
    MARY EDYTHE WILSON; Fiscal Year: 2010
    ..Through a coordinated approach in the three laboratories, we will systematically perform pre-clinical testing against several Leishmania species, with the goal of developing a pan-leishmania protective vaccine. ..
  41. HUMAN ANTIBODIES TO CRYPTOCOCCUS NEOFORMANS
    Liise Anne Pirofski; Fiscal Year: 2009
    ..neoformans and provide proof of principle that vaccines can be developed that focus the immune response on cellular subsets that can induce protection: ..
  42. Ca2+-Pumps in Plants: Pollen Growth and Fertilization
    Jeffrey Harper; Fiscal Year: 2008
    ..In addition, aca9 is gene level that disrupts pollen-tube/ovule and yeast provide an innovative approach calmodulin-regulated calcium pump. Our pump, PMCA4, which has been implicated ..
  43. Functional Genomics of Cryptosporidium parvum
    Giovanni Widmer; Fiscal Year: 2007
    ..parvum. A comparison of the host cell response to C. parvum type 1 and type 2 will be performed to probe the molecular basis of the observed difference in virulence between types. ..
  44. Cytoskeletal organization in apicomplexan parasites
    Heide Schatten; Fiscal Year: 2005
    ..Pilot data from this RO3 research will be used to apply for funding through the RO1 mechanism. ..
  45. Mitochondria distribution in cloned pig embryos
    Heide Schatten; Fiscal Year: 2005
    ..Pilot data from this RO3 small grants program research will be used to apply for funding through the RO1 mechanism. ..
  46. LUMINAL CONTROL OF CALCIUM RELEASE BY CALRETICULIN
    Patricia Camacho; Fiscal Year: 2005
    ..abstract_text> ..
  47. MOLECULAR GENETICS OF OLFACTION IN ANOPHELINE MOSQUITOES
    LAURENCE ZWIEBEL; Fiscal Year: 2004
    ..gambiae s.s. and it's zoophilic non-vector sibling An. quadriannulatus to identify and characterize peripheral olfactory genes, which are specifically associated with anthropophily and/or zoophily. ..
  48. Comparison of US and European Babesia divergens Isolates
    Patricia Holman; Fiscal Year: 2004
    ..The molecular aspects may provide information that will be useful in future efforts to devise diagnostic tests. ..
  49. MOLECULAR BASIS OF PERSISTENT EHRLICHIA INFECTION
    XUE JIE YU; Fiscal Year: 2004
    ..chaffeensis. This will provide valuable information regarding the potential use of these antigens as subunit vaccines. ..
  50. Microarray Studies of Vibro cholerae EPS Regulation
    Gary Schoolnik; Fiscal Year: 2003
    ..abstract_text> ..
  51. The Major Surface Protease of Trypanosomatid Protozoa
    Mary Wilson; Fiscal Year: 2003
    ..chagasi whose coding sequences predict they lack the usual GPI anchor, and to contrast the amino acid sequences that regulate the intracellular trafficking of these unusual MSPs with the MSPs that possess a GPI membrane anchor. ..
  52. CELLULAR DEFENSE RESPONSE IN AN INSECT SYSTEM
    MICHAEL STRAND; Fiscal Year: 2005
    ....
  53. DNA BASE EXCISION REPAIR IN PLASMODIUM FALCIPARUM
    THEODORE TARASCHI; Fiscal Year: 2005
    ..falciparum and mammalian cells to develop new strategies for antimalarial therapy. ..
  54. Comparative rickettsial protein profiles during tick infection
    KEVIN MACALUSO; Fiscal Year: 2007
    ..To better understand the mechanisms of rickettsial virulence, this project seeks to examine the interplay between spotted fever group Rickettsia and the vector tick. [unreadable] [unreadable] [unreadable]..
  55. Gammacell-220 Excel Refurbished Research Irradiator
    David Walker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  56. Mucosal Immune Responses in Hookworm Infection
    Richard Bungiro; Fiscal Year: 2006
    ..These studies are expected to further our understanding of host-parasite immunological interaction and advance hookworm vaccine research through the development of novel immunization techniques. ..
  57. High Throughput Assay for Screening Compounds(RMI)
    James McKerrow; Fiscal Year: 2005
    ..Computational and informatics capability is in place to acquire, store and cross-reference this data, and provide access to the scientific community through an open-source website. ..
  58. Marker development for mosquito hemocytes
    MICHAEL STRAND; Fiscal Year: 2006
    ..The results of this study will provide essential tools for understanding the role of different hemocytes in cellular immunity of An. gambiae and likely other species of mosquitoes. ..
  59. TRANSMISSION OF PAUCIBACILLARY AND DRUG RESISTANT TB
    Gary Schoolnik; Fiscal Year: 2004
    ..tuberculosis and begin to exploit this information for improved genotyping and diagnostic systems. ..
  60. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2005
    ..For the field of Lyme disease, defining the key molecules expressed by tick-borne spirochetes will move us one step closer toward understanding how this pathogen invades, disseminates and persists in the mammalian host. ..
  61. Gut Epithelial Cell Receptors for C parvum Invasion
    ROBERTA O CONNOR; Fiscal Year: 2005
    ..New England Medical Center, in association with Tufts University and the wider Boston scientific community provides researchers with diverse and excellent scientific resources, and is exceptional environment for a young scientist...
  62. ADENOSINE KINASE TARGET FOR CHEMOTHERAPY IN TGONDII
    MAHMOUD EL KOUNI; Fiscal Year: 2001
    ..gondii; (3) evaluate active compounds as potential antitoxoplasmosis agents in vitro and in vivo. ..