biological adaptation

Summary

Summary: Changes in biological features that help an organism cope with its ENVIRONMENT. These changes include physiological (ADAPTATION, PHYSIOLOGICAL), phenotypic and genetic changes.

Top Publications

  1. ncbi Adaptive protein evolution in Drosophila
    Nick G C Smith
    Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK
    Nature 415:1022-4. 2002
  2. ncbi The genetic theory of adaptation: a brief history
    H Allen Orr
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nat Rev Genet 6:119-27. 2005
  3. ncbi Biological robustness
    Hiroaki Kitano
    Sony Computer Science Laboratories, Inc, 3 14 13 Higashi Gotanda, Shinagawa, Tokyo 141 0022, Japan
    Nat Rev Genet 5:826-37. 2004
  4. ncbi Perspective: Evolution and detection of genetic robustness
    J Arjan G M de Visser
    Department of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    Evolution 57:1959-72. 2003
  5. ncbi Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation
    Santiago F Elena
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, 46022 Valencia, Spain
    Nat Rev Genet 4:457-69. 2003
  6. ncbi Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila
    Daven C Presgraves
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nature 423:715-9. 2003
  7. ncbi An equivalence principle for the incorporation of favorable mutations in asexual populations
    Matthew Hegreness
    Bauer Center for Genomics Research, Harvard University, Cambridge, MA 02138, USA
    Science 311:1615-7. 2006
  8. ncbi Co-mimics have a mutualistic relationship despite unequal defences
    Hannah M Rowland
    School of Biological Sciences, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK
    Nature 448:64-7. 2007
  9. pmc Genome-wide patterns of nucleotide substitution reveal stringent functional constraints on the protein sequences of thermophiles
    Robert Friedman
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    Genetics 167:1507-12. 2004
  10. ncbi Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution
    M Anisimova
    Department of Biology, Galton Laboratory, University College London, London, England
    Mol Biol Evol 18:1585-92. 2001

Research Grants

  1. Staining Techniques for Micro-CT Imaging of Microdamage
    RYAN ROEDER; Fiscal Year: 2004
  2. Statistical Studies of Genomic Evolution
    Masatoshi Nei; Fiscal Year: 2009
  3. Towards a general theory of evolutionary capacitance
    Joanna Masel; Fiscal Year: 2009
  4. BIOSYNTHESIS OF VITAMIN B12 AND ANAEROBIC METABOLISM
    John Roth; Fiscal Year: 2004
  5. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
  6. JWatcher-event recorder and behavioral analysis program
    DANIEL BLUMSTEIN; Fiscal Year: 2004
  7. Molecular mechanism of DNA-polymerase choice in vivo
    Susan Rosenberg; Fiscal Year: 2007
  8. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
  9. DNA REPAIR IN DRUG RESISTANCE MUTATION
    Susan Rosenberg; Fiscal Year: 2003
  10. WORKSHOPS IN FORMAL DEMOGRAPHY AND BIODEMOGRAPHY
    Shripad Tuljapurkar; Fiscal Year: 2008

Detail Information

Publications247 found, 100 shown here

  1. ncbi Adaptive protein evolution in Drosophila
    Nick G C Smith
    Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK
    Nature 415:1022-4. 2002
    ..yakuba. We estimate that 45% of all amino-acid substitutions have been fixed by natural selection, and that on average one adaptive substitution occurs every 45 years in these species...
  2. ncbi The genetic theory of adaptation: a brief history
    H Allen Orr
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nat Rev Genet 6:119-27. 2005
    ..I also discuss the challenges that face contemporary theories of adaptation...
  3. ncbi Biological robustness
    Hiroaki Kitano
    Sony Computer Science Laboratories, Inc, 3 14 13 Higashi Gotanda, Shinagawa, Tokyo 141 0022, Japan
    Nat Rev Genet 5:826-37. 2004
    ..Insights into inherent properties of robust systems will provide us with a better understanding of complex diseases and a guiding principle for therapy design...
  4. ncbi Perspective: Evolution and detection of genetic robustness
    J Arjan G M de Visser
    Department of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    Evolution 57:1959-72. 2003
    ....
  5. ncbi Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation
    Santiago F Elena
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, 46022 Valencia, Spain
    Nat Rev Genet 4:457-69. 2003
    ....
  6. ncbi Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila
    Daven C Presgraves
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nature 423:715-9. 2003
    ..These results show that a lethal hybrid incompatibility has evolved as a by-product of adaptive protein evolution...
  7. ncbi An equivalence principle for the incorporation of favorable mutations in asexual populations
    Matthew Hegreness
    Bauer Center for Genomics Research, Harvard University, Cambridge, MA 02138, USA
    Science 311:1615-7. 2006
    ..The effective parameters constitute a simple description and provide a natural standard for comparing adaptation between species and across environments...
  8. ncbi Co-mimics have a mutualistic relationship despite unequal defences
    Hannah M Rowland
    School of Biological Sciences, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK
    Nature 448:64-7. 2007
    ..By ignoring the effects of density, current theories may have overestimated the parasitic costs imposed by less defended mimics on highly defended models...
  9. pmc Genome-wide patterns of nucleotide substitution reveal stringent functional constraints on the protein sequences of thermophiles
    Robert Friedman
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    Genetics 167:1507-12. 2004
    ....
  10. ncbi Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution
    M Anisimova
    Department of Biology, Galton Laboratory, University College London, London, England
    Mol Biol Evol 18:1585-92. 2001
    ..The exact distribution assumed for the omega ratio over sites was found not to affect the effectiveness of the LRT...
  11. pmc Restrictions on biological adaptation in language evolution
    Nick Chater
    Department of Cognitive, Perceptual and Brain Sciences, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 106:1015-20. 2009
    ..As suggested by Darwin, the fit between language and its underlying mechanisms arose because language has evolved to fit the human brain, rather than the reverse...
  12. ncbi Counteracting selective regimes and host preference evolution in ecotypes of two species of walking-sticks
    C P Sandoval
    Marine Science Institute, University of California, Santa Barbara 93106, USA
    Evolution 59:2405-13. 2005
    ..Our results shed light onto which traits are involved in the initial stages of ecological specialization and ecologically based reproductive isolation...
  13. ncbi Perspective: models of speciation: what have we learned in 40 years?
    Sergey Gavrilets
    Department of Ecology and Evolutionary Biology, Department of Mathematics, University of Tennessee, Knoxville, Tennessee 37996, USA
    Evolution 57:2197-215. 2003
    ..Sympatric speciation is promoted if costs of being choosy are small (or absent) and if linkage between the loci experiencing disruptive selection and those controlling assortative mating is strong...
  14. ncbi Does gene flow constrain adaptive divergence or vice versa? A test using ecomorphology and sexual isolation in Timema cristinae walking-sticks
    P Nosil
    Department of Biosciences, Behavioral Ecology Research Group, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Evolution 58:102-12. 2004
    ..Our findings illustrate how data on mating preferences can help determine the causal associations between trait divergence and levels of gene flow...
  15. ncbi Reduced adaptation of a non-recombining neo-Y chromosome
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Nature 416:323-6. 2002
    ..Our results provide evidence for the importance of sexual recombination for increasing and maintaining the level of adaptation of a population...
  16. pmc Cloning of mammalian Ire1 reveals diversity in the ER stress responses
    X Z Wang
    Skirball Institute of Biomolecular Medicine, the Departments of Medicine, Cell Biology and the Kaplan Cancer Center, NYU Medical Center, New York, NY 10016, USA
    EMBO J 17:5708-17. 1998
    ..These results indicate that a single upstream component, Ire1, plays a role in multiple facets of the ER stress-response in mammalian cells...
  17. ncbi Hotter is better and broader: thermal sensitivity of fitness in a population of bacteriophages
    Jennifer L Knies
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am Nat 173:419-30. 2009
    ..We found that the temperature sensitivity of fitness for phages is similar to that for insects...
  18. ncbi Genetic linkage of ecological specialization and reproductive isolation in pea aphids
    D J Hawthorne
    Department of Entomology, University of Maryland, College Park 20742, USA
    Nature 412:904-7. 2001
    ..This type of genetic architecture may be common in taxa that have speciated under divergent natural selection...
  19. ncbi Evolvability
    Paul D Sniegowski
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    Curr Biol 16:R831-4. 2006
  20. ncbi How much of the variation in adaptive divergence can be explained by gene flow? An evaluation using lake-stream stickleback pairs
    Andrew P Hendry
    Redpath Museum and Department of Biology, McGill University, Montreal, Quebec H3A 2K6, Canada
    Evolution 58:2319-31. 2004
    ..This effect seems relatively unimportant for our system because genetic divergence and gene flow were not correlated with ecologically relevant habitat features of lakes (surface area) or streams (width, depth, flow, canopy openness)...
  21. ncbi Missense meanderings in sequence space: a biophysical view of protein evolution
    Mark A DePristo
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Genet 6:678-87. 2005
    ..We then advance a biophysical model of protein evolution that helps us to understand phenomena that range from the dynamics of molecular adaptation to the clock-like rate of protein evolution...
  22. ncbi Quantitative trait locus analyses and the study of evolutionary process
    David L Erickson
    Laboratory of Analytical Biology, Smithsonian Institution, Suitland, MD 20746, USA
    Mol Ecol 13:2505-22. 2004
    ..Throughout this review we attempt to provide a balanced description of the benefits of QTL methodology to studies in ecology and evolution as well as the inherent assumptions and limitations that may constrain its application...
  23. pmc The frailty of adaptive hypotheses for the origins of organismal complexity
    Michael Lynch
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 104:8597-604. 2007
    ....
  24. ncbi Error thresholds and the constraints to RNA virus evolution
    Edward C Holmes
    Department of Zoology, University of Oxford, South Parks Road, OX1 3PS, Oxford, UK
    Trends Microbiol 11:543-6. 2003
    ..Documenting the constraints to RNA virus evolution has important implications for predicting the emergence of new viruses and for improving therapeutic procedures...
  25. pmc Adaptation and immunity
    Eddie C Holmes
    Department of Zoology at the University of Oxford, Oxford, United Kingdom
    PLoS Biol 2:E307. 2004
  26. ncbi The evolution of premating isolation: local adaptation and natural and sexual selection against hybrids
    Maria R Servedio
    Department of Biology, CB 3280, Coker Hall, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Evolution 58:913-24. 2004
    ..I present some situations in which this type of selection is likely to exist. This work also illustrates shortfalls of using a weak selection approach to address questions about reinforcement...
  27. ncbi Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress
    Megan N Hersh
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm S809, Mail Stop 225, Houston, TX 77030 3411, USA
    Res Microbiol 155:352-9. 2004
    ..Stress-induced genetic changes may underlie much of microbial evolution, pathogenesis and antibiotic resistance, and also cancer formation, progression and drug resistance...
  28. ncbi Host race formation in the Acari
    Sara Magalhães
    Instituto Gulbenkian de Ciencia, Evolutionary Genetics Group, Rua da Quinta Grande, 6, 2780 156 Oeiras, Portugal
    Exp Appl Acarol 42:225-38. 2007
    ..We discuss future directions for research on host-associated adaptations in this group of organisms and the potential relevance of host race formation for the biodiversity of mites and ticks...
  29. ncbi Molecular adaptation and the origin of land plants
    Elizabeth R Waters
    Department of Biology, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 4614, USA
    Mol Phylogenet Evol 29:456-63. 2003
    ..In this review I summarize the current knowledge of a variety of physiological and biochemical adaptations to land including plant growth hormones, isoprene, phenolics, and heat shock proteins...
  30. pmc Synthetic gene recruitment reveals adaptive reprogramming of gene regulation in yeast
    Elad Stolovicki
    Department of Physics, Technion Israel Institute of Technology, Haifa 32000, Israel
    Genetics 173:75-85. 2006
    ..The results reveal heritable adaptation induced by the exposure to glucose. They demonstrate that genetic regulatory networks have the potential to support highly demanding events of gene recruitment...
  31. pmc Experimental evidence that predation promotes divergence in adaptive radiation
    Patrik Nosil
    Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
    Proc Natl Acad Sci U S A 103:9090-5. 2006
    ..Our results indicate that both competition and predation may commonly serve as mechanisms of adaptive radiation...
  32. ncbi Host-range evolution in Aphidius parasitoids: fidelity, virulence and fitness trade-offs on an ancestral host
    Lee M Henry
    Department of Biological Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6 Canada
    Evolution 62:689-99. 2008
    ....
  33. ncbi The biological limitations of transcriptomics in elucidating stress and stress responses
    M E Feder
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    J Evol Biol 18:901-10. 2005
    ..In view of this outcome, transcriptomics should undergo careful cost-benefit analysis before investigators deploy it in studies of stress responses and their evolution...
  34. ncbi Adaptation and diversification on islands
    Jonathan B Losos
    Museum of Comparative Zoology, 26 Oxford Street, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 457:830-6. 2009
    ..For these reasons, island research provides valuable insights into speciation and adaptive radiation, and into the relative importance of contingency and determinism in evolutionary diversification...
  35. pmc Local adaptation and vector-mediated population structure in Plasmodium vivax malaria
    Deirdre A Joy
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biol Evol 25:1245-52. 2008
    ....
  36. ncbi Adaptive dynamics of dormancy duration variability: evolutionary trade-off and priority effect lead to suboptimal adaptation
    Sébastien Gourbière
    Université de Perpignan Via Domitia UMR 5244 CNRS EPHE UPVD, Laboratoire de Biologie et d Ecologie Tropicale et Méditerranéenne, 52 Avenue Paul Alduy, 66860 Perpignan Cedex, France
    Evolution 63:1879-92. 2009
    ..Such "evolutionary priority effect" could drive the evolution of maladapted levels of diapause-duration variability...
  37. pmc The specificity and polymorphism of the MHC class I prevents the global adaptation of HIV-1 to the monomorphic proteasome and TAP
    Boris V Schmid
    Institute of Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 3:e3525. 2008
    ..We estimate that upon transmission of a virus to a new host 39%-66% of the mutations that caused epitope precursor escapes are released from immune selection pressure...
  38. ncbi Capturing the superorganism: a formal theory of group adaptation
    A Gardner
    Institute of Evolutionary Biology, University of Edinburgh, King s Buildings, Edinburgh, UK
    J Evol Biol 22:659-71. 2009
    ....
  39. ncbi Maximum-likelihood analysis of molecular adaptation in abalone sperm lysin reveals variable selective pressures among lineages and sites
    Z Yang
    Galton Laboratory, Department of Biology, University College London, London, England
    Mol Biol Evol 17:1446-55. 2000
    ..Sites under potential diversifying selection were identified. Ancestral lysins were inferred to trace the route of evolution at individual sites and to provide lysin sequences for future laboratory studies...
  40. pmc Genetic and fitness changes accompanying adaptation of an arbovirus to vertebrate and invertebrate cells
    S C Weaver
    Center for Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Virol 73:4316-26. 1999
    ..Our results suggest that alternating host transmission cycles constrain the evolutionary rates of arboviruses but not their fitness for either host alone...
  41. pmc The evolution of Müllerian mimicry
    Thomas N Sherratt
    Department of Biology, Carleton University, Ottawa, Ontario, Canada
    Naturwissenschaften 95:681-95. 2008
    ..I highlight areas for future enquiry, including the possibility of Müllerian mimicry systems based on profitability rather than unprofitability and the co-evolution of defence...
  42. ncbi Adaptive mutations in bacteria: high rate and small effects
    Lilia Perfeito
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, Number 6, 2780 156 Oeiras, Portugal
    Science 317:813-5. 2007
    ..Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity...
  43. ncbi The interaction of sexually and naturally selected traits in the adaptive radiations of cichlid fishes
    Walter Salzburger
    Zoological Institute, University of Basel, Vesalgasse 1, 4051 Basel, Switzerland
    Mol Ecol 18:169-85. 2009
    ....
  44. pmc Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence
    S P Kennedy
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    Genome Res 11:1641-50. 2001
    ..5) GC-skew analysis showed evidence for the existence of two replication origins in the large chromosome. This finding and the occurrence of multiple chromosomes indicate a dynamic genome organization with eukaryotic character...
  45. pmc Towards a theory of biological robustness
    Hiroaki Kitano
    Mol Syst Biol 3:137. 2007
  46. ncbi The evolution of müllerian mimicry in multispecies communities
    Christopher D Beatty
    Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada
    Nature 431:63-6. 2004
    ..This need to simplify decision making readily facilitates the spread of imperfect mimetic forms from rarity, and suggests that müllerian mimicry is more likely to arise in multispecies communities...
  47. ncbi A scan for signatures of positive selection in candidate loci for skin pigmentation in humans
    Neskuts Izagirre
    Department Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country, Leioa, Bizkaia, Spain
    Mol Biol Evol 23:1697-706. 2006
    ....
  48. pmc Are adaptation costs necessary to build up a local adaptation pattern?
    Sara Magalhães
    Laboratoire de Génétique et Environnement, Institut des Sciences de l Evolution, Universite de Montpellier II, Place Eugène Bataillon Bâtiment 22 cc65, 34095 Montpellier, France
    BMC Evol Biol 9:182. 2009
    ..The occurrence of such trade-offs is inferred by a pattern of local adaptation, i.e., a negative correlation between relative performance on different hosts...
  49. ncbi Over the falls? Rapid evolution of ecotypic differentiation in steelhead/rainbow trout (Oncorhynchus mykiss)
    Devon E Pearse
    Fisheries Ecology Division, Southwest Fisheries Science Center, NOAA National Marine Fisheries Service, Santa Cruz, CA 95060, USA
    J Hered 100:515-25. 2009
    ..These results support a hypothesis of rapid evolution of a purely resident life history in the above-barrier population in response to strong selection against downstream movement...
  50. ncbi Age of cichlids: new dates for ancient lake fish radiations
    Martin J Genner
    Department of Biological Sciences, University of Hull, Cottingham Road, Hull HU6 7RX, UK
    Mol Biol Evol 24:1269-82. 2007
    ....
  51. ncbi Gene gain and gene loss in streptococcus: is it driven by habitat?
    Pradeep Reddy Marri
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Biol Evol 23:2379-91. 2006
    ..We have analyzed here some of the experimentally characterized species-specific genes that have been acquired by LGT and conclude that at least a portion of these genes have a role in adaptation...
  52. pmc How does resource supply affect evolutionary diversification?
    Alex R Hall
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 274:73-8. 2007
    ..These processes may underlie some general patterns of diversity, including latitudinal gradients in species richness and the effects of anthropogenic enrichment of the environment...
  53. pmc Adaptive molecular evolution for 13,000 phage generations: a possible arms race
    Holly A Wichman
    Department of Biological Sciences, University of Idaho, Moscow, 83844 3051, USA
    Genetics 170:19-31. 2005
    ..We instead suggest that continuing molecular evolution reflects a potentially indefinite arms race, stemming from high levels of co-infection and the resulting conflict among genomes competing within the same cell...
  54. ncbi Distributions of epistasis in microbes fit predictions from a fitness landscape model
    Guillaume Martin
    Centre d écologie fonctionnelle et évolutive Centre National de la Recherche Scientifique UMR 5175, 1919 Route de Mende, 34293 Montpellier, France
    Nat Genet 39:555-60. 2007
    ..This model may offer a simple and widely applicable alternative to complex metabolic network models, in particular for making evolutionary predictions...
  55. ncbi A single amino acid mutation contributes to adaptive beach mouse color pattern
    Hopi E Hoekstra
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Science 313:101-4. 2006
    ..Here, we link a single mutation in the coding region of a pigmentation gene to adaptive quantitative variation in the wild...
  56. ncbi Using genome scans of DNA polymorphism to infer adaptive population divergence
    Jay F Storz
    Department of Biology, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA 94132, USA
    Mol Ecol 14:671-88. 2005
    ..Finally, I consider the evolutionary and functional insights that might be gained by conducting genome scans for loci involved in adaptive population divergence...
  57. ncbi Biological and biomedical implications of the co-evolution of pathogens and their hosts
    Mark E J Woolhouse
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Nat Genet 32:569-77. 2002
    ....
  58. pmc The first metazoa living in permanently anoxic conditions
    Roberto Danovaro
    Department of Marine Science, Faculty of Science, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy
    BMC Biol 8:30. 2010
    ..Deep seas include some of the most extreme ecosystems on Earth, such as the deep hypersaline anoxic basins of the Mediterranean Sea. These are permanently anoxic systems inhabited by a huge and partly unexplored microbial biodiversity...
  59. pmc Facilitated variation: how evolution learns from past environments to generalize to new environments
    Merav Parter
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    PLoS Comput Biol 4:e1000206. 2008
    ..Thus, environments that change in a systematic, modular fashion seem to promote facilitated variation and allow evolution to generalize to novel conditions...
  60. pmc Bacterial metapopulations in nanofabricated landscapes
    Juan E Keymer
    Department of Physics, Princeton University, Princeton, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 103:17290-5. 2006
    ..Our results illustrate the potential lying at the interface between nanoscale biophysics and landscape evolutionary ecology...
  61. pmc Positive selection at the protein network periphery: evaluation in terms of structural constraints and cellular context
    Philip M Kim
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:20274-9. 2007
    ..e., extracellular space or cell membrane). This suggests that the observed positive selection at the network periphery may be due to an increase of adaptive events on the cellular periphery responding to changing environments...
  62. pmc Parallel genotypic adaptation: when evolution repeats itself
    Troy E Wood
    Indiana University, 1001 E Third St, Jordan Hall 142, Bloomington, IN 47405, USA
    Genetica 123:157-70. 2005
    ....
  63. ncbi Adaptive radiation in microbial microcosms
    R Craig MacLean
    Department of Biology, McGill University, Montreal QC, Canada
    J Evol Biol 18:1376-86. 2005
    ..The implications of microbial selection experiments for evolutionary theory are discussed and future directions of research are proposed...
  64. ncbi Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens
    Nitzan Mekel-Bobrov
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Science 309:1720-2. 2005
    ..These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution...
  65. ncbi A phylogenetic test for adaptive convergence in rock-dwelling lizards
    Liam J Revell
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Evolution 61:2898-912. 2007
    ....
  66. pmc Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor
    W B Klimstra
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Virol 72:7357-66. 1998
    ..Adaptive mutations, selected during cell culture growth of Sindbis virus, enhance binding and infectivity by allowing the virus to attach by an alternative mechanism that is dependent on the presence of cell surface HS...
  67. pmc Multiple pathways of selected gene amplification during adaptive mutation
    Elisabeth Kugelberg
    Section of Microbiology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 103:17319-24. 2006
    ..These findings are relevant to genetic adaptation in any biological systems in which fitness can be increased by adding gene copies (e.g., cancer and bacterial drug resistance)...
  68. ncbi Microbial experiments on adaptive landscapes
    Nick Colegrave
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Bioessays 27:1167-73. 2005
    ..Laboratory populations of microbes allow evolution to be observed in real time and, as such, provide key insights into the topology of adaptive landscapes...
  69. pmc The rate of compensatory mutation in the DNA bacteriophage phiX174
    Art Poon
    Division of Biological Sciences, Section of Ecology, Behavior and Evolution, University of California, San Diego, California 92093 0116, USA
    Genetics 170:989-99. 2005
    ..We estimate that about half of all compensatory mutations are located extragenically in this organism...
  70. ncbi Comparative analysis of morphological diversity: does disparity accumulate at the same rate in two lineages of centrarchid fishes?
    David C Collar
    Section of Evolution and Ecology, University of California, Davis 95616, USA
    Evolution 59:1783-94. 2005
    ..4 and 7.7 times greater in Lepomis. Thus, time and phylogeny do not account for the differences in morphological disparity observed in Lepomis and Micropterus, and other diversity-promoting mechanisms should be investigated...
  71. ncbi Properties of adaptive walks on uncorrelated landscapes under strong selection and weak mutation
    Darin R Rokyta
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
    J Theor Biol 243:114-20. 2006
    ..As in Orr's original model, these results are insensitive to both the distribution of fitness effects and most biological details of the system under consideration...
  72. ncbi Spontaneous emergence of modularity in a model of evolving individuals
    Jun Sun
    Department of Physics and Astronomy and Department of Bioengineering, Rice University, Houston, Texas 77005 1892, USA
    Phys Rev Lett 99:228107. 2007
    ..We suggest that the hierarchical structure observed in the natural world may be a broken-symmetry state, which generically results from evolution in a changing environment...
  73. ncbi Adaptive value of sex in microbial pathogens
    Richard E Michod
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Infect Genet Evol 8:267-85. 2008
    ..For example, antibiotic resistance may be transferred by bacterial sex, but this transfer is probably not the reason sex evolved in bacteria...
  74. pmc Extensive genome rearrangements and multiple horizontal gene transfers in a population of pyrococcus isolates from Vulcano Island, Italy
    James R White
    University of Maryland, College Park, Maryland, USA
    Appl Environ Microbiol 74:6447-51. 2008
    ..The results illustrate the dynamic nature of the genomes of the genus Pyrococcus and raise the possibility of a connection between rapidly changing environmental conditions and adaptive genomic properties...
  75. ncbi Tempo and mode of evolutionary radiation in iguanian lizards
    Luke J Harmon
    Department of Biology, Campus Box 1137, Washington University, St Louis, MO 63130 4899, USA
    Science 301:961-4. 2003
    ..This inverse relationship between timing of diversification and morphological disparity within subclades may be a general feature that transcends the historically contingent properties of different evolutionary radiations...
  76. ncbi Evolutionary genomics of host adaptation in vesicular stomatitis virus
    Susanna K Remold
    Department of Biology, University of Louisville, USA
    Mol Biol Evol 25:1138-47. 2008
    ..We discuss the degree to which current genetic architecture is expected to constrain future evolution of complex traits, such as host use by RNA viruses...
  77. pmc Deterministic and stochastic regimes of asexual evolution on rugged fitness landscapes
    Kavita Jain
    Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
    Genetics 175:1275-88. 2007
    ..We argue that our findings are relevant to the interpretation of evolution experiments with microbial populations...
  78. pmc Protein evolution in deep sea bacteria: an analysis of amino acids substitution rates
    Stefano Campanaro
    CRIBI Biotechnology Centre, Department of Biology, University of Padua, Via U Bassi 38 b, 35121, Padua, Italy
    BMC Evol Biol 8:313. 2008
    ..To verify this hypothesis we computed the amino acid substitution rates between two deep-sea microorganisms, Photobacterium profundum SS9 and Shewanella benthica KT99, and their respective shallow water relatives...
  79. pmc Comprehensive mutation identification in an evolved bacterial cooperator and its cheating ancestor
    Gregory J Velicer
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 103:8107-12. 2006
    ..These results provide insight into the genetic basis of two large adaptive transitions in a social bacterium...
  80. pmc Role of the mutant spectrum in adaptation and replication of West Nile virus
    Alexander T Ciota
    Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    J Gen Virol 88:865-74. 2007
    ..These data provide evidence of the importance of quasispecies dynamics in the adaptation of a flavivirus to new and changing environments and hosts, with little evidence of significant genetic change...
  81. pmc Transient and heritable mutators in adaptive evolution in the lab and in nature
    S M Rosenberg
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Genetics 148:1559-66. 1998
    ....
  82. ncbi Viral ecology and the maintenance of novel host use
    John J Dennehy
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
    Am Nat 167:429-39. 2006
    ..We argue that this effect should facilitate adaptation by the virus to utilize the novel host--often crucial in subsequent phases of emergence...
  83. ncbi Evolution of antioxidant defence mechanisms
    I F Benzie
    Department of Nursing and Health Sciences, Hong Kong Polytechnic University, Kowloon, China
    Eur J Nutr 39:53-61. 2000
    ..Finally, suggested benefits underlying our curious inability to manufacture ascorbic acid, and the possible role of uric acid in human antioxidant defence, are briefly discussed with particular reference to nutrition and toxicology...
  84. ncbi Optimization of inclusive fitness
    Alan Grafen
    St John s College, Oxford OX1 3JP, UK
    J Theor Biol 238:541-63. 2006
    ..Important questions remain to be answered in the fundamental theory of inclusive fitness...
  85. ncbi Ecological and evolutionary diversification of the seed beetle genus Stator (Coleoptera: Chrysomelidae: Bruchinae)
    Geoffrey E Morse
    Department of Entomology, One Shields Avenue, University of California, Davis, CA 95616, USA
    Evolution 59:1315-33. 2005
    ..The results of this study show that diversification is structured by interactions between different selective pressures and along multiple ecological axes...
  86. ncbi A minimum on the mean number of steps taken in adaptive walks
    H Allen Orr
    Department of Biology, University of Rochester, Rochester, NY 14627, U S A
    J Theor Biol 220:241-7. 2003
    ..Put differently, evolution must try out at least e wild-type sequences during an average bout of adaptation...
  87. ncbi Testing hypotheses about ecological specialization using phylogenetic trees
    P Nosil
    Department of Biosciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Evolution 59:2256-63. 2005
    ..Most generally, inferences regarding character evolution can be strengthened by comparing models of character change and examining ancestor states, rather than only comparing parameter values...
  88. ncbi Ecology. Making sense of evolution in an uncertain world
    Vincent A A Jansen
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK
    Science 309:2005-7. 2005
  89. pmc Experimental evolution and genome sequencing reveal variation in levels of clonal interference in large populations of bacteriophage phiX174
    Kim M Pepin
    Department of Biological Sciences, University of Idaho, Moscow, ID, 83844 3051, USA
    BMC Evol Biol 8:85. 2008
    ..Genomic sequences of multiple individuals from evolved populations were used to detect competing beneficial mutations...
  90. ncbi The adaptive landscape as a conceptual bridge between micro- and macroevolution
    S J Arnold
    Department of Zoology, Oregon State University, Corvallis 97331, USA
    Genetica 112:9-32. 2001
    ..We also sketch an agenda of empirical issues that is inspired by theoretical developments...
  91. pmc Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria
    B R Levin
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Genetics 154:985-97. 2000
    ....
  92. pmc The evolution of bet-hedging adaptations to rare scenarios
    Oliver D King
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Theor Popul Biol 72:560-75. 2007
    ..In this case, the approximate requirements for bet-hedging to be favored by a ratio of at least R are that sN>log(R) and thetaN>square root R ...
  93. pmc Maladaptation and the paradox of robustness in evolution
    Steven A Frank
    Department of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, California, United States of America
    PLoS ONE 2:e1021. 2007
    ..Such buffering mechanisms are often discussed in terms of robustness, which may be measured by reduced sensitivity of performance to perturbations...
  94. ncbi Spatial mosaic formation through frequency-dependent selection in Müllerian mimicry complexes
    Thomas N Sherratt
    Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6
    J Theor Biol 240:165-74. 2006
    ..Overall, this model highlights how a stable mosaic of different mimetic forms can evolve from a range of starting conditions through a combination of chance effects and localized frequency-dependent selection...
  95. ncbi Adaptive evolution of fertilization proteins within a genus: variation in ZP2 and ZP3 in deer mice (Peromyscus)
    Leslie M Turner
    Division of Biological Sciences, University of California, San Diego, USA
    Mol Biol Evol 23:1656-69. 2006
    ..These findings demonstrate that the pattern of adaptive reproductive protein evolution found at higher taxonomic levels can be documented between closely related mammalian species, where reproductive isolation has evolved recently...
  96. pmc Widespread adaptive evolution of Drosophila genes with sex-biased expression
    Matthias Pröschel
    Section of Evolutionary Biology, Department of Biology II, University of Munich LMU, 82152 Munich, Germany
    Genetics 174:893-900. 2006
    ..melanogaster and D. simulans. This suggests that sexual selection and intersexual coevolution are the major forces driving genetic differentiation between species...
  97. ncbi The genetics of adaptation in Drosophila sechellia
    Corbin D Jones
    Department of Biology, Carolina Center for Genome Science, University of North Carolina, Chapel Hill, NC 27599, USA
    Genetica 123:137-45. 2005
    ..The data from D. sechellia suggest that adaptations are not as genetically complex as historically thought, although almost all of the adaptations of D. sechellia involve several genes...
  98. pmc Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae
    Ghislaine Guillemain
    CEA, Direction des Sciences du Vivant, Institut de Biologie et de la Technologies de Saclay, 91191 Gif sur Yvette Cedex, France
    Mol Cell Biol 27:3378-89. 2007
    ..Our data thus strongly suggest that CK2 is the kinase responsible for the in vivo phosphorylation of Ptc2 T376...
  99. ncbi Fitness effects of beneficial mutations: the mutational landscape model in experimental evolution
    Andrea J Betancourt
    Institute for Evolutionary Biology, King s Buildings, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Curr Opin Genet Dev 16:618-23. 2006
    ....
  100. pmc Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection
    Silvana Gaudieri
    Centre for Clinical Immunology and Biomedical Statistics, Level 2, North Block, Royal Perth Hospital, Wellington St, Perth, Western Australia 6000, Australia
    J Virol 80:11094-104. 2006
    ..This analysis of host-virus interaction reveals evidence of HCV adaptation to HLA class I-restricted immune pressure and identifies in vivo targets of cellular immune responses at the population level...
  101. ncbi History and the global ecology of squamate reptiles
    Laurie J Vitt
    Sam Noble Oklahoma Museum of Natural History and Zoology Department, University of Oklahoma, Norman, Oklahoma 73072, USA
    Am Nat 162:44-60. 2003
    ..These historically derived niche differences are apparent in extant lizard assemblages and account for some observed structure. These patterns occur in a variety of habitats at both regional and local levels throughout the world...

Research Grants68

  1. Staining Techniques for Micro-CT Imaging of Microdamage
    RYAN ROEDER; Fiscal Year: 2004
    ..From a biological adaptation standpoint, damage with the bone tissue is believed to stimulate remodeling...
  2. Statistical Studies of Genomic Evolution
    Masatoshi Nei; Fiscal Year: 2009
    ..of multigene families arid the origins of new genes and new genetic systems that are important for biological adaptation. In the next grant period we will focus on the evolution of the primate KIR and the rodent Ly49 gene ..
  3. Towards a general theory of evolutionary capacitance
    Joanna Masel; Fiscal Year: 2009
    ..Since direct experiments on capacitance cannot be performed in humans, the theoretical and predictive approach described here is particularly important for understanding the scope of capacitance in explaining human variation. ..
  4. BIOSYNTHESIS OF VITAMIN B12 AND ANAEROBIC METABOLISM
    John Roth; Fiscal Year: 2004
    ..coli. Understanding this metabolism may contribute to understanding the natural lifestyle of Salmonellae. ..
  5. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  6. JWatcher-event recorder and behavioral analysis program
    DANIEL BLUMSTEIN; Fiscal Year: 2004
    ..While we will continue to freely-distribute the software, on-going support and routine updates will be supported by the sales of a detailed users manual, which will include laboratory exercises suitable for teaching. ..
  7. Molecular mechanism of DNA-polymerase choice in vivo
    Susan Rosenberg; Fiscal Year: 2007
    ..coli DNA polymerases, and functions in DNA polymerase choice in vivo: a critical regulatory decision for cell survival of environmental damage, and genomic health. [unreadable] [unreadable] [unreadable]..
  8. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  9. DNA REPAIR IN DRUG RESISTANCE MUTATION
    Susan Rosenberg; Fiscal Year: 2003
    ....
  10. WORKSHOPS IN FORMAL DEMOGRAPHY AND BIODEMOGRAPHY
    Shripad Tuljapurkar; Fiscal Year: 2008
    ..unreadable] DESCRIPTION (provided by applicant): Applicant did not provide description. [unreadable] [unreadable] [unreadable]..
  11. SECRETIONS OF ARTHROPODS
    Thomas Eisner; Fiscal Year: 2008
    ..Insects are major vectors of disease. An understanding of how insects depend on natural products for regulation of their biotic interactions is of broad applied significance to both medicine and agriculture. [unreadable] [unreadable]..
  12. PATHOGENIC ADAPTATION OF MICROBIAL ADHESINS
    EVGENI VENIAMINOVIC SOKURENKO; Fiscal Year: 2010
    ..Studies proposed here will serve as model ones to provide a spectrum of novel information regarding shear effects on bacterial adhesion, particularlyin connection to the bacterial pathogenesis. ..
  13. Evolutionary genomics of new Drosophila genes
    DAVEN PRESGRAVES; Fiscal Year: 2004
    ..The methods developed will be applicable in comparative analysis of other genomes, including those of humans and their primate relatives. ..
  14. Evolution of vertebrate sensory genes
    Jianzhi Zhang; Fiscal Year: 2010
    ..These studies will also help understand human smell and taste variations and disorders. ..
  15. Mechanisms of Adaptive Amplification
    Philip J Hastings; Fiscal Year: 2010
    ....
  16. Mammalian Genomes - Stasis and Change
    HOLLY WICHMAN; Fiscal Year: 2009
    ..This proposal will also ask whether changes in patterns of methylation by endocrine disruptors is linked to increased rates of retrotransposition. ..
  17. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  18. "WORKSHOPS IN FORMAL AND QUANTITATIVE DEMOGRAPHY"
    Shripad Tuljapurkar; Fiscal Year: 2005
    ..Second, a three-day Mini-workshop in advanced modeling and analysis organized around specialized topics (forecasting in year 1, biodemographic models in year 2). ..
  19. EID - Effects of avian migration & anthropogenic change on the distribution & tra
    Thomas Smith; Fiscal Year: 2009
    ..Finally, we will share our results with public health organizations and the scientific community in a timely fashion in order to maximize the public good. ..
  20. Pathways of T cell Senescence
    ABBE DE VALLEJO; Fiscal Year: 2009
    ....
  21. Agilent 6890 GC/5973 mass detector for Profiling
    Roger Davis; Fiscal Year: 2005
    ..The projected use of each investigator is shown in table 1 and will account for 100% time use. Therefore, we have no alternative equipment for this essential technique. ..
  22. Interdisciplinary Study of Acid-Meditated Tumor Invasion
    Robert Gatenby; Fiscal Year: 2005
    ..Perturbations that produce slowing or reversal of the traveling wave solution to the state equations (ie tumor growth) will be explored to predict possible new treatment strategies. ..
  23. SLEEP ACADEMIC AWARD--RECOGNITION OF SLEEP DISORDERS
    Kingman Strohl; Fiscal Year: 2002
    ..We will disseminate of educational assessments, patient-oriented material, and clinical pathways through local and national consultants in both the public and private sector, as well as through interaction with other awardees. ..
  24. Transcriptional Coactivators in Liver Function
    Janardan Reddy; Fiscal Year: 2008
    ..These studies are expected to generate new information, with implications for human impact, which could provide novel avenues for developing strategies to regulate gene function by altering coactivator activity. ..
  25. Regulation of Pregnancy-Dependent Adaptations
    Michael Soares; Fiscal Year: 2009
    ..Novel ideas and a novel research approach have been presented to elucidate regulatory mechanisms controlling fundamental processes essential for the establishment and maintenance of pregnancy. ..
  26. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ....
  27. P.Gingivalis and Oral Keratinocyte-ECM Interactions
    Vito Quaranta; Fiscal Year: 2004
    ..g. may initiate and sustain periodontal disease. Such clues may be useful for devising new modalities of treatment and prevention. ..
  28. Interdisciplinary Training in Genetics and Complex Disease(RMI)
    Marianne Wessling Resnick; Fiscal Year: 2008
    ..abstract_text> ..
  29. Models of Sensory Coding
    Michael Leon; Fiscal Year: 2008
    ..These experiments should help us understand the mechanism by which the olfactory nervous system codes complex stimuli. ..
  30. INTRAUTERINE ASPHYXIAL ENCEPHALOPATHY
    Peter Gluckman; Fiscal Year: 2001
    ..By further elucidating the pathogenesis of prenatal and perinatal asphyxial encephalopathy these studies will provide important information towards improving perinatal diagnosis, monitoring and intervention. ..
  31. FUNCTIONS AND INTERACTIONS OF PRESENILINS
    KENNETH KOSIK; Fiscal Year: 2003
    ....
  32. MOLECULAR CHAPERONES OF CLASS I MHC
    Ted Hansen; Fiscal Year: 2003
    ..Our knowledge of the precise mechanism of peptide loading in the ER is key to understanding how viral pathogens abrogate immune recognition and how we might design future protocols for constructive intervention. ..
  33. Modeling the Spatial Dynamics of Plasmid Transfer
    STEPHEN KRONE; Fiscal Year: 2009
    ....
  34. A MODEL SYSTEM FOR PREDICTING EVOLUTIONARY POTENTIAL
    Barry Hall; Fiscal Year: 2003
    ..The resulting mutants will then be characterized to determine which kind of data most accurately predicted the eventual evolutionary outcome. ..
  35. SLEEP AND ENTERTAIMENT OF SCN FUNCTION
    Kingman Strohl; Fiscal Year: 2002
    ..abstract_text> ..
  36. Molecular Regulation of Intergrin Function
    Vito Quaranta; Fiscal Year: 2002
    ..Hopefully, with these Aims we will be able to outline a coherent picture as to how Ln-5, integrins and MMP interact to regulate cell adhesion and migration in the context of tissue organization and remodeling. ..
  37. FASEB Conference: Mechanisms of Liver Growth and Disease
    Janardan Reddy; Fiscal Year: 2002
    ..abstract_text> ..
  38. ROLE OF NITRIC OXIDE IN FERTILIZATION
    David Epel; Fiscal Year: 2002
    ..The possible role of NO in regulating the egg's ion channels (as part of polyspermy block) and sperm physiology (such as motility and the acrosome reaction) will also be investigated. ..
  39. Functional Genomics of Cryptosporidium parvum
    Giovanni Widmer; Fiscal Year: 2007
    ..parvum. A comparison of the host cell response to C. parvum type 1 and type 2 will be performed to probe the molecular basis of the observed difference in virulence between types. ..
  40. APO B TRANSLOCATION AND DEGRADATION
    Roger Davis; Fiscal Year: 2007
    ..We are confident that our proposed studies will provide new insights that will add further proof to the feasibility and advance the therapeutic potential of controlling the apo B processing pathway. ..
  41. Development of Cdk5 Inhibitors
    KENNETH KOSIK; Fiscal Year: 2007
    ..Because compound validation requires a broad expertise that is unlikely to be present in a single lab we have assembled individuals who collectively have the expertise to complete the aims. ..
  42. The Rate and Molecular Spectrum of Spontaneous Mutations
    Michael Lynch; Fiscal Year: 2009
    ....
  43. MATERNAL ADAPTATIONS TO PREGNANCY
    Michael Soares; Fiscal Year: 2001
    ..abstract_text> ..
  44. EVOLUTIONARY GENETICS OF VERTEBRATE VISION
    Shozo Yokoyama; Fiscal Year: 2002
    ..abstract_text> ..
  45. Role of Leptin in Systemic Lupus Erythematosus
    Antonio La Cava; Fiscal Year: 2010
    ..This study will detail the effects of leptin on human lupus and compare the potential of different leptin-based approaches with the goal to improve the current therapeutic management of human lupus. ..
  46. Role of Microstructure in Nanomechanical Behavior of Bone Tissue
    Marjolein C van der Meulen; Fiscal Year: 2010
    ..Our approach will cross-correlate several microlevel techniques that have not been previously used to characterize bone tissue mechanics. ..
  47. Genes controlling heart function in a hibernating mammal
    Matthew Andrews; Fiscal Year: 2005
    ..abstract_text> ..
  48. A Genomic Study of Sex-Role and Social Dominance
    SUSAN RENN; Fiscal Year: 2006
    ..In addition to evolutionary implications, these studies will inform further hypotheses to be tested through functional analysis. ..
  49. A Wireless, Multi-Channel Telemetric Biosensor for Research in Animal Models
    Kingman Strohl; Fiscal Year: 2006
    ..The proposed research will facilitate animal studies that may lead to a better understanding of sleep disorders and potentially new interventions. [unreadable] [unreadable] [unreadable]..
  50. Fluorescence-based screen to probe hepcidin-ferroportin interactions
    Marianne Wessling Resnick; Fiscal Year: 2006
    ..The project has broader applicability in the development of HTS to assay ligand-receptor interactions as well as representing a major advance towards the discovery of small molecule probes of iron transport. ..
  51. LYMPHOCYTE RECEPTORS FOR VASOACTIVE INTESTINAL PEPTIDE
    EDWARD GOETZL; Fiscal Year: 2007
    ..abstract_text> ..
  52. MOLECULAR GENETICS OF THERMOGENESIS
    LESLIE KOZAK; Fiscal Year: 2007
    ..Concurrent with gene identification, the experiments will provide phenotypic information on how these genes affect the development of excessive adiposity. ..
  53. Aquaporin 5 (AQP5) in Lung Fluid Homeostasis
    CARISSA KRANE; Fiscal Year: 2004
    ..This combinatorial approach will provide valuable information for the identification of new mechanistic pathways critical for the development of novel drug targets for the treatment of asthma. ..
  54. GENETICS OF DEVELOPMENTAL PLASTICITY IN THE ADIPOCYTE
    LESLIE KOZAK; Fiscal Year: 2004
    ..Finally (Aim 5), candidate cDNAs or genes will be tested by complementation in a cell culture system based on preadipocytes or BAC transgenesis using B6.A congenics. ..
  55. Experimental tests of vocal learning in songbirds
    David Lahti; Fiscal Year: 2007
    ..abstract_text> ..
  56. Ex Vivo Delineation of Mechanisms of Cerebral Vasospasm
    JAY HUMPHREY; Fiscal Year: 2008
    ..In summary, we submit that this project will reveal new insight into mechanisms. ..
  57. Development of RNAi as Treatment for Neurodegeneration
    KENNETH KOSIK; Fiscal Year: 2005
    ..These experiments open the way for the Colombian scientists to participate directly in the next phase of the research beyond descriptive genetics in which the Colombian group has made such a strong contribution. ..
  58. Novel Organ Culture & Theory for Arteriolar Remodeling
    JAY HUMPHREY; Fiscal Year: 2005
    ..We will collect simultaneous pressure-diameter, cell morphological, and actin cytoskeletal data at multiple times during the remodeling, which in turn will allow us to develop a novel, single theoretical framework. ..
  59. Compound Identification in Assays for Tau Pathology
    KENNETH KOSIK; Fiscal Year: 2004
    ..This proposal principally involves work at two sites. They are the Kosik laboratory in the Center for Neurologic Diseases and the Laboratory for Drug Discovery for Neurodegeneration (LDDN) under the direction of Ross Stein. ..
  60. The Regulation of Neuronal miRNA Expression
    KENNETH KOSIK; Fiscal Year: 2004
    ..In particular, impaired neuronal polarity acquisition, synaptogenesis, and translation of specific mRNAs are possible phenotypic outcomes of Dicer suppression. ..
  61. International Conference on Molecular Systems Biology
    Michael Savageau; Fiscal Year: 2004
    ..Contributions are accepted based on peer review by a 14-member Scientific Committee. Selected papers will be proposed for further review and, if accepted, subsequent publication in a special issue of Mathematical Biosciences. ..