water electrolyte balance

Summary

Summary: The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, etc., maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.

Top Publications

  1. ncbi Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor
    F Posas
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 86:865-75. 1996
  2. ncbi An osmosensing signal transduction pathway in yeast
    J L Brewster
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251
    Science 259:1760-3. 1993
  3. ncbi Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation
    C M Krane
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 276:23413-20. 2001
  4. ncbi Central mechanisms of osmosensation and systemic osmoregulation
    Charles W Bourque
    Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Room L7 216, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
    Nat Rev Neurosci 9:519-31. 2008
  5. ncbi Molecular biology of major components of chloride cells
    Shigehisa Hirose
    Department of Biological Sciences, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Comp Biochem Physiol B Biochem Mol Biol 136:593-620. 2003
  6. pmc Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice
    Y Song
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Physiol 525:771-9. 2000
  7. ncbi A role for negative fluid balance in septic patients with abdominal compartment syndrome?
    Roman Kula
    Intensive Care Med 30:2138-9. 2004
  8. ncbi High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, University of Brussels, Belgium
    Chest 128:3098-108. 2005
  9. pmc Osmosensing by bacteria: signals and membrane-based sensors
    J M Wood
    Department of Microbiology and Guelph Waterloo Centre for Graduate Work in Chemistry, University of Guelph, Guelph, Ontario, Canada N1G
    Microbiol Mol Biol Rev 63:230-62. 1999
  10. ncbi Fluid responsiveness in spontaneously breathing patients: a review of indexes used in intensive care
    Alice Coudray
    Geneva University Hospital, Geneva, Switzerland
    Crit Care Med 33:2757-62. 2005

Detail Information

Publications212 found, 100 shown here

  1. ncbi Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor
    F Posas
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 86:865-75. 1996
    ..We propose that the multistep phosphorelay mechanism is a universal signal transduction apparatus utilized both in prokaryotes and eukaryotes...
  2. ncbi An osmosensing signal transduction pathway in yeast
    J L Brewster
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251
    Science 259:1760-3. 1993
    ..These data define a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment...
  3. ncbi Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation
    C M Krane
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 276:23413-20. 2001
    ..These data show that AQP5 is the major pathway for regulating the water permeability in acinar cells, a critical property of the plasma membrane which determines the flow rate and ionic composition of secreted saliva...
  4. ncbi Central mechanisms of osmosensation and systemic osmoregulation
    Charles W Bourque
    Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Room L7 216, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
    Nat Rev Neurosci 9:519-31. 2008
    ..Here, recent advances in our understanding of the molecular, cellular and network mechanisms that mediate the central control of osmotic homeostasis in mammals are reviewed...
  5. ncbi Molecular biology of major components of chloride cells
    Shigehisa Hirose
    Department of Biological Sciences, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Comp Biochem Physiol B Biochem Mol Biol 136:593-620. 2003
    ....
  6. pmc Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice
    Y Song
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Physiol 525:771-9. 2000
    ....
  7. ncbi A role for negative fluid balance in septic patients with abdominal compartment syndrome?
    Roman Kula
    Intensive Care Med 30:2138-9. 2004
  8. ncbi High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, University of Brussels, Belgium
    Chest 128:3098-108. 2005
    ..We tested the hypothesis that infection/sepsis and use of higher tidal volumes than those applied in the ARDS Network (ARDSnet) study (> 7.4 mL/kg of predicted body weight) would worsen outcome in patients with ALI/ARDS...
  9. pmc Osmosensing by bacteria: signals and membrane-based sensors
    J M Wood
    Department of Microbiology and Guelph Waterloo Centre for Graduate Work in Chemistry, University of Guelph, Guelph, Ontario, Canada N1G
    Microbiol Mol Biol Rev 63:230-62. 1999
    ..Thus, osmoregulatory responses accommodate and exploit the effects of individual cosolvents on cell structure and function as well as the collective contribution of cosolvents to intracellular osmolality...
  10. ncbi Fluid responsiveness in spontaneously breathing patients: a review of indexes used in intensive care
    Alice Coudray
    Geneva University Hospital, Geneva, Switzerland
    Crit Care Med 33:2757-62. 2005
    ..The present review discusses the clinical utility and accuracy of indexes tested as bedside indicators of preload reserve and fluid responsiveness in hypotensive, spontaneously breathing patients...
  11. ncbi Hormonal control of salt and water balance in vertebrates
    Stephen D McCormick
    USGS, Conte Anadromous Fish Research Center, Turners Falls, MA, USA
    Gen Comp Endocrinol 147:3-8. 2006
    ....
  12. pmc Kidney-specific chloride channel, OmClC-K, predominantly expressed in the diluting segment of freshwater-adapted tilapia kidney
    Hiroaki Miyazaki
    Ocean Research Institute, University of Tokyo, 1 15 1 Minamidai, Nakano Ku, Japan
    Proc Natl Acad Sci U S A 99:15782-7. 2002
    ..The localization of OmClC-K and its induction in hypoosmotic media suggest that OmClC-K is involved in Cl(-) reabsorption in the distal tubule of freshwater-adapted tilapia...
  13. pmc Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation
    C M Krane
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Proc Natl Acad Sci U S A 98:14114-9. 2001
    ....
  14. ncbi Changes in gene expression in gills of the euryhaline killifish Fundulus heteroclitus after abrupt salinity transfer
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Am J Physiol Cell Physiol 287:C300-9. 2004
    ..These findings demonstrate unique patterns of ion transporter expression in killifish gills after salinity transfer and illustrate important mechanisms of functional plasticity in ion-transporting epithelia...
  15. ncbi ATP released from astrocytes during swelling activates chloride channels
    Mark Darby
    Neuroscience Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurophysiol 89:1870-7. 2003
    ..We conclude that ATP release via MRP and subsequent autocrine activation of purinergic receptors contributes to the activation of I(Cl,swell) in astrocytes by HOS-induced swelling...
  16. ncbi Ionic mechanisms of regulatory volume increase (RVI) in the human hepatoma cell-line HepG2
    Frank Wehner
    Max Planck Institut fur molekulare Physiologie, Abteilung Epithelphysiologie, Postfach 500247, 44202 Dortmund, Germany
    Pflugers Arch 443:779-90. 2002
    ..In contrast, there is little if any contribution of K(+) conductance, Na(+)/H(+) antiport, Na(+)-K(+)-2Cl(-) symport, and Na(+)/K(+)-ATPase to this process...
  17. ncbi Effects of hypertonic saline-dextran solution in cardiac valve surgery with cardiopulmonary bypass
    Ronaldo Bueno
    Department of Cardiovascular Surgery, Beneficencia Portuguesa Hospital, Sao Paulo, Brazil
    Ann Thorac Surg 77:604-11; discussion 611. 2004
    ..Fluid overload or transient left ventricular failure may occur with HSD infusion in such patients. This study evaluates the cardiorespiratory effects and tolerance of HSD solution infusion in patients undergoing cardiac valve surgery...
  18. ncbi Dynamics of the vacuolar H(+)-ATPase in the contractile vacuole complex and the endosomal pathway of Dictyostelium cells
    Margaret Clarke
    Oklahoma Medical Research Foundation, Oklahoma City, USA
    J Cell Sci 115:2893-905. 2002
    ..VatM-GFP was retrieved from the phagosome membrane prior to exocytosis of the indigestible remnants of the yeast particle. These data suggest that vacuolar proton pumps are recycled by fusion of advanced with newly formed endosomes...
  19. ncbi Efficacy of continuous hemodiafiltration for patients with congestive heart failure
    Kazuya Nakanishi
    Department of Emergency and Critical Care Medicine, Chiba University School of Medicine, Chiba, Japan
    Blood Purif 20:342-8. 2002
    ..In severe cases, however, we have usually applied continuous hemodiafiltration (CHDF) as a type of mechanical support. In this study, we investigated hemodynamic changes caused by CHDF in patients with congestive heart failure...
  20. ncbi Altering fish embryos with aquaporin-3: an essential step toward successful cryopreservation
    M Hagedorn
    Department of Reproductive Science, Smithsonian Institution, National Zoological Park and Conservation and Research Center, Washington, District of Columbia 20008, USA
    Biol Reprod 67:961-6. 2002
    ..Modeling indicates that sufficient cryoprotectant enters aquaporin-3-expressing zebrafish embryos to allow cryopreservation...
  21. ncbi [Haemodynamic effects following preoperative hypervolemic haemodilution with hypertonic hyperoncotic colloid solutions in coronary artery bypass graft surgery]
    G P Molter
    Klinik für Anaesthesie und Operative Intensivmedizin, Klinikum Leverkusen gGmbH, Leverkusen
    Anaesthesist 52:905-18. 2003
    ....
  22. ncbi First use of hypertonic saline dextran in children: a study in safety and effectiveness for atrial septal defect surgery
    Roberto Rocha-E-Silva
    Division of Surgery, Sao Paulo University School of Medicine, Sao Paulo, Brazil 05403 900
    Shock 20:427-30. 2003
    ..Its effective doses produce negative fluid balance and reduce blood/derivative requirements...
  23. ncbi Regulation of rat APJ receptor messenger ribonucleic acid expression in magnocellular neurones of the paraventricular and supraopric nuclei by osmotic stimuli
    A M O'Carroll
    University Research Centre for Neuroendocrinology, University of Bristol, Bristol, UK
    J Neuroendocrinol 15:661-6. 2003
    ..These data verify a role for APJ receptors in body fluid regulation and suggest a role for apelin in the regulation of vasopressin-containing neurones via a local autocrine/paracrine action of the peptide...
  24. ncbi Neuroendocrine control of body fluid homeostasis
    S M McCann
    Pennington Biomedical Research Center LSU, Baton Rouge, LA 70808 4124, USA
    Braz J Med Biol Res 36:165-81. 2003
    ..The natriuresis induced by cGMP finally causes blood volume to return to normal. At the same time, the ANP released acts centrally to decrease water and salt intake...
  25. ncbi The role of the kidney in protecting the brain against cerebral edema and neuronal cell swelling
    Russell W Chesney
    J Pediatr 152:4-6. 2008
  26. ncbi [Effects of equiosmolar load of 20% mannitol, 7.5% saline and 0.9% saline on plasma osmolarity, haemodynamics and plasma concentrations of electrolytes]
    A C Erard
    Division d anesthésiologie département d anesthésiologie, Pharmacologie et Soins Intensifs Chirurgicaux, Hopital Cantonal Universitaire de Geneve, 1211 Geneve 14, Suisse
    Ann Fr Anesth Reanim 22:18-24. 2003
    ..The objectives of this study were to compare the pharmacokinetics of both solutions in an equiosmolar load with an isotonic solution (NaCl 0.9% (C)) in terms of osmolarity, electrolytes and haemodynamic parameters over time...
  27. ncbi NAD(P)H oxidase-derived H(2)O(2) signals chloride channel activation in cell volume regulation and cell proliferation
    Diego Varela
    Instituto de Ciencias Biomédicas and Centro de Estudios Moleculares de la Célula Facultad de Medicina Universidad de Chile, Santiago 6530499, Santiago, Chile
    J Biol Chem 279:13301-4. 2004
    ..It is concluded that NAD(P)H oxidase-derived H(2)O(2) is the common signal transducing molecule that mediates the activation of these ubiquitously expressed anion channels under a variety of physiological conditions...
  28. ncbi Osmotic swelling-provoked release of organic osmolytes in human intestinal epithelial cells
    Sebastian F B Tomassen
    Department of Biochemistry, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Am J Physiol Cell Physiol 286:C1417-22. 2004
    ..Taken together, the results indicate that the hypotonicity-induced efflux of organic osmolytes is independent of VRAC and involves a PKC-dependent step...
  29. pmc Management of fluid balance in the very immature neonate
    N Modi
    Faculty of Medicine, Imperial College of Science, Technology and Medicine, Westminster Hospital, London, UK
    Arch Dis Child Fetal Neonatal Ed 89:F108-11. 2004
    ..Preterm birth requires rapid adaptation from a liquid to a gaseous, low humidity environment. There are several ways in which this can be facilitated. The management of sodium and water balance is considered here...
  30. ncbi Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats
    Anaya Mitra
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
    Physiol Behav 89:221-5. 2006
    ....
  31. ncbi Evidence for recycling of contractile vacuole membrane during osmoregulation in Dictyostelium amoebae--a tribute to Günther Gerisch
    John Heuser
    Eur J Cell Biol 85:859-71. 2006
  32. ncbi Fluid and electrolyte management in the very low birth weight neonate
    J Bhatia
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    J Perinatol 26:S19-21. 2006
    ....
  33. ncbi Gene cloning and expression of an aquaporin (AQP-h3BL) in the basolateral membrane of water-permeable epithelial cells in osmoregulatory organs of the tree frog
    Gen Akabane
    Department of Biology, Faculty of Science, Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan
    Am J Physiol Regul Integr Comp Physiol 292:R2340-51. 2007
    ..Thus, water homeostasis in the frog body is regulated by AQP-h3BL expressed in the basolateral membrane in concert with arginine vasotocin (AVT)-dependent or AVT-independent AQP...
  34. ncbi Clinical insights into adipsic diabetes insipidus: a large case series
    R K Crowley
    Academic Department of Endocrinology, Beaumont Hospital RCSI Medical School, Dublin 9, Ireland
    Clin Endocrinol (Oxf) 66:475-82. 2007
    ....
  35. ncbi Fluid balance and weaning outcomes
    Anupama Upadya
    Pulmonary and Critical Care, Bridgeport Hospital and Yale University School of Medicine, 267 Grant Street, Bridgeport, CT 06610, USA
    Intensive Care Med 31:1643-7. 2005
    ..To examine the relationship of fluid balance and weaning outcomes...
  36. pmc Furosemide-induced renal medullary hypoperfusion in the rat: role of tissue tonicity, prostaglandins and angiotensin II
    Leszek Dobrowolski
    Laboratory of Renal Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Physiol 567:613-20. 2005
    ..Adenosine is not involved in medullary vascular responses to decreased tissue hypertonicity...
  37. pmc A positive fluid balance is associated with a worse outcome in patients with acute renal failure
    Didier Payen
    Department of Anesthesiology and Intensive Care, CHU Lariboisière, 2, rue Ambroise Pare, F 75475 Paris Cedex 10, France
    Crit Care 12:R74. 2008
    ..The aim of the present observational study was to analyze the influence of patient characteristics and fluid balance on the outcome of ARF in intensive care unit (ICU) patients...
  38. ncbi Expression and distribution of Na, K-ATPase in gill and kidney of the spotted green pufferfish, Tetraodon nigroviridis, in response to salinity challenge
    C H Lin
    Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan
    Comp Biochem Physiol A Mol Integr Physiol 138:287-95. 2004
    ....
  39. ncbi Potentiation of the osmosensitive release of taurine and D-aspartate from SH-SY5Y neuroblastoma cells after activation of M3 muscarinic cholinergic receptors
    Anne M Heacock
    Mental Health Research Institute Laboratories at MSRB II, 1150 West Medical Center Dr, C560, MSRB II, University of Michigan, Ann Arbor, MI 48109 0669, USA
    J Pharmacol Exp Ther 311:1097-104. 2004
    ..mAChR-stimulated osmolyte efflux is mediated via a VSOAC and seems to require the activity of a tyrosine kinase...
  40. ncbi A potassium channel-linked mechanism of glial cell swelling in the postischemic retina
    Thomas Pannicke
    Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    Mol Cell Neurosci 26:493-502. 2004
    ..Inhibition of these water fluxes may be beneficial to prevent ischemia-evoked glial cell swelling...
  41. pmc Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release
    Nadia De Mota
    Institut National de la Sante et de la Recherche Medicale, Unite 36, College de France, 75231 Paris, France
    Proc Natl Acad Sci U S A 101:10464-9. 2004
    ..The coexistence of apelin and AVP in magnocellular neurons, their opposite biological effects, and regulation are likely to play a key role for maintaining body fluid homeostasis...
  42. ncbi Comparative water metabolism of Barrow Island macropodid marsupials: hormonal versus behavioural-dependent mechanisms of body water conservation
    J M King
    School of Animal Biology M092 and Centre for Native Animal Research, University of Western Australia, Perth, WA 6009, Australia
    Gen Comp Endocrinol 155:378-85. 2008
    ..These species appear to lack ADH-controlled renal systems for the conservation of body water and are thus dependent on behavioural strategies for the maintenance of fluid homeostasis in arid environments...
  43. ncbi Vasopressin secretion: osmotic and hormonal regulation by the lamina terminalis
    M J McKinley
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia
    J Neuroendocrinol 16:340-7. 2004
    ....
  44. pmc An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum
    Samuel J Fountain
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Nature 448:200-3. 2007
    ..Cell swelling in these mutant cells was accompanied by a marked inhibition of contractile vacuole emptying. These findings demonstrate a new functional role for P2X receptors on intracellular organelles, in this case in osmoregulation...
  45. pmc Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases
    Xin Ling Du
    Institute of Cardiovascular Science and Medicine Department of Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    J Gen Physiol 123:427-39. 2004
    ..Regulation is complex, however. Src and EGFR kinases, distinct soluble and receptor-mediated PTK families, have opposing effects on I(Cl.vol), and multiple target proteins are likely to be involved...
  46. ncbi Contribution of comparative fish studies to general endocrinology: structure and function of some osmoregulatory hormones
    Yoshio Takei
    Laboratory of Physiology, Ocean Research Institute, University of Tokyo, Nakano Ku, Tokyo 164 8639, Japan
    J Exp Zool A Comp Exp Biol 305:787-98. 2006
    ..Because of the functional and molecular diversification of ion-regulating hormones in fishes, this approach sometimes leads to the discovery of new hormones in tetrapods as exemplified by adrenomedullin 2...
  47. ncbi Hypertonic saline (7.5%) decreases perioperative weight gain following cardiac surgery
    Kati Järvelä
    Department of Anaesthesia and Intensive Care, Tampere University Hospital, Tampere, Finland
    J Cardiothorac Vasc Anesth 16:43-6. 2002
    ..To compare the effects of 7.5% hypertonic saline (HS) and 0.9% normal saline (NS) on perioperative weight gain in cardiac surgical patients...
  48. pmc Selective response of human airway epithelia to luminal but not serosal solution hypertonicity. Possible role for proximal airway epithelia as an osmolality transducer
    N J Willumsen
    Department of Medicine, University of North Carolina, Chapel Hill 27599
    J Clin Invest 94:779-87. 1994
    ..We speculate that these properties configure human nasal epithelium to behave as an osmotic sensor, transducing information about luminal solutions to the airway wall...
  49. ncbi Effects of hyperosmolarity and ion substitutions on amino acid efflux from the ischemic rat cerebral cortex
    J W Phillis
    Department of Physiology, Wayne State University School of Medicine, 540 E Canfield Ave, Detroit, MI 48201, USA
    Brain Res 828:1-11. 1999
    ....
  50. ncbi Osmoregulation of natriuretic peptide receptors in bromoethylamine-treated rat kidney
    Kuichang Yuan
    Department of Cardiology, Yanbian University Hospital, Yanji, Jilin Province, China
    Peptides 30:1137-43. 2009
    ..These results suggest that the increased cGMP production may be partly involved in the decrease in NPRs mRNA expression and their binding capacities by BEA-induced medullectomy...
  51. ncbi Regulation of aquaporin-2 water channel trafficking by vasopressin
    M A Knepper
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 0951, USA
    Curr Opin Cell Biol 9:560-4. 1997
    ..The vesicle-targeting proteins synaptobrevin-2 and syntaxin-4 are proposed to play roles in this process...
  52. ncbi Expression of the Na+K+-2CI- cotransporter in alpha and beta cells isolated from the rat pancreas
    A Majid
    School of Biological Sciences and Department of Medicine, University of Manchester, UK
    Pflugers Arch 442:570-6. 2001
    ..This is consistent with the hypothesis that Cl- is accumulated above the expected equilibrium distribution in beta cells, but is below equilibrium in alpha cells...
  53. pmc Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4
    T Ma
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Clin Invest 100:957-62. 1997
    ....
  54. pmc Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli
    Michel Azizi
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, and INSERM, CIC 9201, Paris, France
    J Am Soc Nephrol 19:1015-24. 2008
  55. ncbi Relationship between volume status and blood pressure during chronic hemodialysis
    John K Leypoldt
    University of Utah, Salt Lake City, Utah 84112 5350, USA
    Kidney Int 61:266-75. 2002
    ..Specifically, the effect of interdialytic fluid accumulation (or intradialytic fluid removal) on BP is controversial...
  56. ncbi Promoter selectivity control of Escherichia coli RNA polymerase by ionic strength: differential recognition of osmoregulated promoters by E sigma D and E sigma S holoenzymes
    Q Ding
    Department of Molecular Genetics, National Institute of Genetics, Shizuoka, Japan
    Mol Microbiol 16:649-56. 1995
    ....
  57. ncbi A review of water balance in ageing in health and disease
    N R Stout
    Cardiovascular Investigation Unit, Royal Victoria Infirmary, Newcastle upon Tyne
    Gerontology 45:61-6. 1999
    ..The changes in these systems, when combined with coincident disease, place elderly patients at risk of water imbalance and electrolyte disturbance...
  58. ncbi Osmol gaps in the pediatric population
    K K McQuillen
    Department of Emergency Medicine, Rhode Island Hospital, Brown University, Providence, USA
    Acad Emerg Med 6:27-30. 1999
    ..To define the osmol gap (OG) range in pediatric ED (PED) patients...
  59. ncbi Negative fluid balance predicts survival in patients with septic shock: a retrospective pilot study
    F Alsous
    Division of Pulmonary and Critical Care, Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT 06610, USA
    Chest 117:1749-54. 2000
    ..We hypothesized that patients with septic shock who achieve negative fluid balance (< or =-500 mL) on any day in the first 3 days of management are more likely to survive than those who do not...
  60. ncbi Osmotic regulation of neuronal activity: a new role for taurine and glial cells in a hypothalamic neuroendocrine structure
    N Hussy
    Biologie des Neurones Endocrines CNRS UPR 9055 CCIPE, 141 rue de la Cardonille 34094 Cedex 5, Montpellier, France
    Prog Neurobiol 62:113-34. 2000
    ..These observations extend the role of taurine from the regulation of cell volume to that of the whole body fluid balance. They also point to a new role of supraoptic glial cells as active components in a neuroendocrine regulatory loop...
  61. ncbi Osmoregulation in marine mammals
    R M Ortiz
    Department of Biology, University of California, Santa Cruz, CA 95064, USA
    J Exp Biol 204:1831-44. 2001
    ..The antidiuretic role of vasopressin remains inconclusive in marine mammals, while the natriuretic function of atrial natriuretic peptide has yet to be examined. Ideas on the direction of future studies are presented...
  62. ncbi Water and electrolyte homeostasis and kidney function of desert-dwelling marsupial wallabies in Western Australia
    S D Bradshaw
    Department of Zoology and Centre for Native Animal Research, The University of Western Australia, Perth
    J Comp Physiol B 171:22-32. 2001
    ..The secure nature of their rock habitat, however, means that they have suffered less than hare-wallabies in the recent past...
  63. ncbi Regulation of water absorption in the frog skins by two vasotocin-dependent water-channel aquaporins, AQP-h2 and AQP-h3
    Takahiro Hasegawa
    Department of Biology, Faculty of Science, Shizuoka University, Shizuoka 422 8529, Japan
    Endocrinology 144:4087-96. 2003
    ..Taken together, these findings suggest that not only AQP-h3, but also AQP-h2 acts as a regulator of the water balance in this frog...
  64. ncbi Osmoregulation of vasopressin release and gene transcription under acute and chronic hypovolemia in rats
    Noriko Kondo
    Department of Metabolic Diseases, Field of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Am J Physiol Endocrinol Metab 286:E337-46. 2004
    ..Thus it was demonstrated that acute and chronic reduction in plasma volume affected the osmoregulation of AVP release and gene transcription in different ways...
  65. ncbi Substantia nigra osmoregulation: taurine and ATP involvement
    Ingrid Morales
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Am J Physiol Cell Physiol 292:C1934-41. 2007
    ..Taken together, present data suggest osmoregulation as a role of the nonsynaptic taurine pool of the SN, a function that also involves glutamate and ATP and that could influence the nigral cell vulnerability in Parkinson's disease...
  66. ncbi Tubular-vesicular transformation in the contractile vacuole system of Dictyostelium
    Gunther Gerisch
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Cell Biol Int 26:845-52. 2002
    ..Proteins that control activities of this specialized organelle in Dictyostelium have been conserved during evolution and also regulate membrane trafficking in man...
  67. ncbi Regulation of cardiac volume-sensitive chloride channel by focal adhesion kinase and Src kinase
    Kenneth B Walsh
    Dept of Pharmacology, Physiology, and Neuroscience, School of Medicine, Univ of South Carolina, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 289:H2566-74. 2005
    ..Furthermore, overexpression of FRNK but not FAK caused a twofold augmentation in I(Cl,swell) and increased the rate of current activation. Thus the tyrosine kinases FAK and Src contribute to the regulation of ICl,swell...
  68. pmc Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes
    Iskandar F Abdullaev
    Ordway Research Institute, Albany, NY 12208, USA
    J Physiol 572:677-89. 2006
    ..Taken together, our data suggest that (i) astrocytic volume-dependent EAA release is largely mediated by the VRAC, and (ii) the ClC-2, ClC-3, ClC-4, ClC-5, VDAC, CaCC, MDR-1 and CFTR gene products do not contribute to EAA permeability...
  69. pmc Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice
    Aleksandra Rojek
    Water and Salt Research Center, Institute of Anatomy, and Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 103:6037-42. 2006
    ..These results demonstrate that AQP2 in CNT is sufficient for postnatal survival and that AQP2 in CD is essential for regulation of body water balance and cannot be compensated for by other mechanisms...
  70. ncbi Hypertonic saline (7.5%) after coronary artery bypass grafting
    K Järvelä
    Department of Anaesthesia and Intensive Care, Tampere University Hospital, PO Box 2000, FIN 33521 Tampere, Finland
    Eur J Anaesthesiol 18:100-7. 2001
    ..Patients undergoing coronary artery bypass grafting often require volume loading after operation. In this situation hypertonic saline may be beneficial in restoring the haemodynamic balance and removing excess extravascular fluid...
  71. ncbi Osmotic distress: a probable cause of fish kills on exposure to a subbloom concentration of the toxic alga Chattonella marina
    Janet Y M Tang
    Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR, People s Republic of China
    Environ Toxicol Chem 23:2727-36. 2004
    ..marina. The findings of this study provide evidence that C. marina, even in concentrations below visible blooms, can pose a significant threat to marine fish...
  72. ncbi Na+-dependent K+ uptake Ktr system from the cyanobacterium Synechocystis sp. PCC 6803 and its role in the early phases of cell adaptation to hyperosmotic shock
    Nobuyuki Matsuda
    Bioscience and Biotechnology Center, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 279:54952-62. 2004
    ..These data indicate that in strain PCC 6803 K(+) uptake via KtrABE plays a crucial role in the early phase of cell turgor regulation after hyperosmotic shock...
  73. ncbi Osmoadaptation and osmoregulation in archaea: update 2004
    Mary F Roberts
    Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA
    Front Biosci 9:1999-2019. 2004
    ..The detailed response of many other archaea to osmotic stress will be needed in order to identify features (aside from some of the organic osmolytes) unique to the organisms in this kingdom...
  74. ncbi Cation specificity of osmosensing by the betaine carrier BetP of Corynebacterium glutamicum
    Dirk Schiller
    Institut fur Biochemie der Universitat zu Koln, Zülpicher Str 47, 50674 Cologne, Germany
    FEBS Lett 563:108-12. 2004
    ..We conclude that activation of BetP in proteoliposomes depends solely on K(+), both in mechanistic and in physiological terms...
  75. ncbi Osmotic effectors in kidneys of xeric and mesic rodents: corticomedullary distributions and changes with water availability
    P H Yancey
    Biology Department, Whitman College, Walla Walla, Washington 99362
    J Comp Physiol B 158:369-80. 1988
    ....
  76. ncbi Ethnic differences in renal responses to furosemide
    Tae Yon Chun
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hypertension 52:241-8. 2008
    ..An increase in vasopressin levels appeared to explain greater urine concentrations in black males but not black females...
  77. ncbi Rehydration after exercise in the heat: a comparison of 4 commonly used drinks
    Susan M Shirreffs
    Sport and Exercise Sciences Faculty, Loughborough University, UK
    Int J Sport Nutr Exerc Metab 17:244-58. 2007
    ..There is a limited range of commercially available products that have a composition sufficient to achieve this, even though the public thinks that some of the traditional drinks are effective for this purpose...
  78. ncbi New insights into fish ion regulation and mitochondrion-rich cells
    Pung Pung Hwang
    Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei, 115, Taiwan
    Comp Biochem Physiol A Mol Integr Physiol 148:479-97. 2007
    ..Several new windows have been opened particularly in terms of molecular mechanisms of ionocyte differentiation and energy metabolite transport between gill cells during environmental challenge...
  79. ncbi [Responses of the rat kidney to the water load test and vasopressin administered during normal feeding and fasting]
    Jie Gao
    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad Sci, 44 M Thorez Av, St Petersburg, 194223, Russia
    Ross Fiziol Zh Im I M Sechenova 90:202-11. 2004
    ..A problem is discussed of the concept of norm under usual conditions and at certain clinically accepted restrictions, for instance, on empty stomach...
  80. ncbi Acute toxicity of ammonia and its effects on the haemolymph osmolality, ammonia-N, pH and ionic composition of early juvenile mud crabs, Scylla serrata (Forskål)
    Nicholas Romano
    School of Marine and Tropical Biology, James Cook University, Townsville, Qld 4811, Australia
    Comp Biochem Physiol A Mol Integr Physiol 148:278-85. 2007
    ..05) from that of the control crabs which coincided with significantly lower (p<0.05) haemolymph Na(+) and Ca(2+) levels. These physiological responses may explain the high ammonia tolerance of early S. serrata juveniles...
  81. ncbi A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
    Koh ichi Wada
    Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
    Biol Pharm Bull 30:91-5. 2007
    ..These results show that conivaptan improves hyponatremia in rats with SIADH, supporting the therapeutic potential of conivaptan in treatment of patients with hyponatremia associated with SIADH...
  82. ncbi Osmo and ionic regulation of black tiger prawn (Penaeus monodon Fabricius 1798) juveniles exposed to K(+) deficient inland saline water at different salinities
    Uras Tantulo
    Muresk Institute, Curtin University of Technology, 1 Turner Avenue Technology Park, Bentley, WA 6102, Australia
    Comp Biochem Physiol A Mol Integr Physiol 146:208-14. 2007
    ..monodon juveniles to regulate serum Na(+), K(+), Ca(2+) and Mg(2+) concentrations. These effects are compounded as salinity increases...
  83. ncbi Rehydration with fluid of varying tonicities: effects on fluid regulatory hormones and exercise performance in the heat
    R W Kenefick
    US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, MA 01760, USA
    J Appl Physiol (1985) 102:1899-905. 2007
    ..Neither a fluid of greater tonicity nor the route of administration resulted in a more rapid or greater fluid retention, nor did it enhance heat tolerance or diminish physiological strain during subsequent exercise in the heat...
  84. ncbi [Vasopressin and prostaglandin E2 as regulators of uropoiesis during children's development]
    A A Kuznetsova
    Fiziol Cheloveka 33:46-54. 2007
  85. ncbi Sodium and potassium excretion in normotensive and hypertensive population in Kashmir
    R A Jan
    Department of Medicine, Sher I Kashmir Institute of Medical Sciences, Srinagar
    J Assoc Physicians India 54:22-6. 2006
    ..20) in patients with hypertension. Thus sodium and potassium excretion, Na+-K+ molar ratio and body mass index has direct bearing in perpetuation or causation of hypertension in Kashmir which may be related to intake of salt tea...
  86. ncbi Role of taurine in osmoregulation during endurance exercise
    Claire Cuisinier
    Institut d éducation physique et de réadaptation, Faculte de Medecine, Universite Catholique de Louvain, 1 Place Pierre de Coubertin, 1348 Louvain la Neuve, Belgium
    Eur J Appl Physiol 87:489-95. 2002
    ..In conclusion, changes in the plasma taurine content during endurance exercise is related to an osmoregulatory process, but this alone does not control plasma volume changes...
  87. ncbi Sweat and sodium losses in NCAA football players: a precursor to heat cramps?
    John R Stofan
    Gatorade Sports Science Institute, Barrington, IL 60010, USA
    Int J Sport Nutr Exerc Metab 15:641-52. 2005
    ..Large acute sodium and fluid losses (in sweat) may be characteristic of football players with a history of heat cramping...
  88. ncbi Impact of nitrite exposure on endocrine, osmoregulatory and cytoprotective functions in the marine teleost Sparus sarba
    Eddie E Deane
    Department of Biology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Aquat Toxicol 82:85-93. 2007
    ..Taken together, the findings from this study provide new insights into how nitrite affects osmoregulatory, endocrine processes and heat shock protein expression in a marine fish...
  89. ncbi Fluid and electrolyte intake and loss in elite soccer players during training
    Ronald J Maughan
    School of Sport and Exercise Sciences at Loughborough University, Leicestershire, UK
    Int J Sport Nutr Exerc Metab 14:333-46. 2004
    ..Voluntary fluid intake also shows wide inter-individual variability and is generally insufficient to match fluid losses...
  90. ncbi Kidney function and the role of arginine vasotocin in three agamid lizards from habitats of differing aridity in Western Australia
    S S Ford
    School of Animal Biology M092 and Centre for Native Animal Research, 35 Stirling Hwy, The University of Western Australia, Perth, WA 6009, Australia
    Gen Comp Endocrinol 147:62-9. 2006
    ..Yet, differences remain in their response to hypernatraemia which may reflect the aridity of their different environments, or their varying habits...
  91. ncbi Are large amounts of sodium stored in an osmotically inactive form during sodium retention? Balance studies in freely moving dogs
    Erdmann Seeliger
    Institut fur Physiologie, Charité Universitätsmedizin Berlin CCM, Tucholskystr 2, 10117 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R1429-35. 2006
    ..This Na+ storage, however, is osmotically active, since osmotical equilibration is achieved by opposite redistribution of K+...
  92. ncbi Seawater drinking restores water balance in dehydrated harp seals
    Ole Jakob How
    Department of Arctic Biology and Institute of Medical Biology, University of Tromsø, Breivika, Tromsø 9037, Norway
    J Comp Physiol B 177:535-42. 2007
    ..In conclusion, this study shows that harp seals have the capacity to gain net water from mariposa (voluntarily drinking seawater) and are able to restore water balance after profound dehydration by drinking seawater...
  93. ncbi Internal sodium balance in DOCA-salt rats: a body composition study
    Jens Titze
    Forschungslabor der Medizinischen Klinik IV, Kreuzburger Strasse 2, 90471 Nürnberg, Germany
    Am J Physiol Renal Physiol 289:F793-802. 2005
    ..This "internal Na(+) escape" allows the maintenance of volume homeostasis despite increased total body Na(+)...
  94. ncbi COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction
    Rikke Nørregaard
    The Water and Salt Research Center, University of Aarhus, Denmark
    Am J Physiol Renal Physiol 289:F322-33. 2005
    ..These data indicate that COX-2 may be an important factor contributing to the impaired renal water and sodium handling in response to BUO...
  95. ncbi Intramembranous absorption rate is unaffected by changes in amniotic fluid composition
    D Anderson
    Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, Oregon 97291, USA
    Am J Physiol Renal Physiol 288:F964-8. 2005
    ..We could demonstrate no effect of isovolumic dilution of amniotic fluid on its volume. However, we were able to demonstrate an inverse relationship between amniotic fluid volume and intramembranous absorption (P < 0.02)...
  96. ncbi Induction of the galanin-like peptide gene expression in the posterior pituitary gland after acute osmotic stimulus in rats
    Makoto Kawasaki
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Neurosci Lett 419:125-30. 2007
    ....
  97. ncbi A new method to distinguish the hyponatremia of electrolyte loss from that due to pure solvent changes
    E Bartoli
    Chair of Internal Medicine, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi del Piemonte Orientale A Avogadro, Via Solaroli 17, 28100, Novara, Italy
    Eur J Appl Physiol 101:133-42. 2007
    ..94, P < 0.0001), while the quantitative estimates of Na deficit predicted the PNa values measured after corrective treatment (P < 0.0001). This new method may prove valuable in diagnosing and treating electrolyte derangements...
  98. ncbi Measurement of chemical analytes in vitreous humor: stability and precision studies
    Angelique Gagajewski
    University of Minnesota School of Medicine, Minneapolis, MN, USA
    J Forensic Sci 49:371-4. 2004
    ....
  99. ncbi Adrenergic receptors, Na+/H+ exchange and volume regulation in lungfish erythrocytes
    P Koldkjaer
    School of Biological Science, University of Liverpool, UK
    J Comp Physiol B 172:87-93. 2002
    ..There was, however, no adrenergic stimulation of the NHE in either Protopterus or Lepidosiren. Acidification of the extracellular medium also failed to activate the NHE...
  100. ncbi Osmoregulation in an avian nectarivore, the whitebellied sunbird Nectarinia talatala: response to extremes of diet concentration
    P A Fleming
    Department of Zoology and Entomology, University of Pretoria, Pretoria 0002, South Africa
    J Exp Biol 206:1845-54. 2003
    ....
  101. ncbi Regulation of the paracellular Na+ and Cl- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients
    Shinsaku Tokuda
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 366:464-70. 2008
    ....

Research Grants14

  1. PHYSIOLOGICAL MECHANISMS OF VERTEBRATE FREEZE TOLERANCE
    RICHARD LEE JR; Fiscal Year: 1991
    ..Additionally, this research could conceivably provide important insight into significant biomedical problems related to water and electrolyte balance, cold exposure, glucose metabolism, and hypoxia...
  2. HYPOTHALAMIC NEURONAL SENSITIVITY IN PREGNANT RATS
    DORANNA CHRISTENSON; Fiscal Year: 1990
    ..Interactions between these factors will be studied; and comparisons made of the various neuronal populations (and their sensitivities) in the pregnant and non-pregnant SHR and WKY animals...
  3. RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCY
    Edmond Quillen; Fiscal Year: 2000
    ..These studies should improve our understanding to the integrative responses of estrogens, ANF and NO during pregnancy. ..
  4. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ....
  5. ALDOSTERONE, RENIN AND PROSTAGLANDINS IN MAN
    Richard Horton; Fiscal Year: 1980
    ..The first will probe the role of prostaglandin and bradykinin during mineralocorticoid escape and the second ascertain whether natiuresis from an acute saline load alters urine PGE and is blunted by PG inhibition...
  6. VOLUME REGULATION IN DIABETES--INTRARENAL MECHANISMS
    Kaushik Patel; Fiscal Year: 2002
    ....
  7. GUSTATORY AFFERENT ORGANIZATION IN THE SOLITARY NUCLEUS
    Susan Travers; Fiscal Year: 1990
    ..Gustatory stimuli also exemplify the important hedonic responses to foods and drink that contribute to inappropriate ingestion patterns and that exascerbate such chronic conditions as obesity and hypertension...
  8. CONTROL OF RENAL FUNCTION BY INTRARENAL ANGIOTENSIN
    Robert Carey; Fiscal Year: 1991
    ..The proposed studies are related to the long term goal of increased understanding of the pathophysiology of hypertension and edema-forming states...
  9. STRUCTURE AND FUNCTION OF THE E. COLI STB ENTEROTOXIN
    LAWRENCE DREYFUS; Fiscal Year: 2000
    ..The result will be the identification of new approaches to therapeutic intervention of intestinal secretory diseases. ..
  10. NEURAL SYSTEMS OF TASTE AND INGESTIVE BEHAVIOR
    Ralph Norgren; Fiscal Year: 2000
    ..In addition to contributing toward a basic understanding of how the nervous system coordinates sensory information into precise physiological and behavioral controls, this research has relevance to the etiology of behavior. ..
  11. PATHOGENESIS AND SEQUELAE OF BARTTER & GORDON SYNDROMES
    Richard Lifton; Fiscal Year: 2000
    ..These findings serve as a paradigm for ongoing genetic studies of true Bartter's syndrome and Gordon's syndrome, and provide further evidence of the key role of the kidney in volume and electrolyte homeostasis. ..
  12. SURGICAL STUDIES ON METABOLISM OF GI HORMONES
    Guillermo Gomez; Fiscal Year: 2003
    ..These studies will provide a foundation for the development of innovative therapeutic strategies designed to exploit the unique biological activities of GI hormones on the exocrine pancreas and intestinal mucosa. ..
  13. Etiology of Age-Related Defects in Urine Concentration
    Ying Tian; Fiscal Year: 2001
    ..abstract_text> ..
  14. C/EDB BETA AND CHOP IN EPIDERMAL DIFFERENTIATION
    Edward Maytin; Fiscal Year: 2002
    ....