physiologic calcification

Summary

Summary: Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.

Top Publications

  1. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
  2. ncbi Impact of anthropogenic CO2 on the CaCO3 system in the oceans
    Richard A Feely
    Pacific Marine Environmental Laboratory, National Oceanic and Atmospheric Administration, Seattle, WA 98115 6349, USA
    Science 305:362-6. 2004
  3. ncbi Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
    A R Hayman
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, UK
    Development 122:3151-62. 1996
  4. ncbi Impact of near-future ocean acidification on echinoderms
    S Dupont
    Department of Marine Ecology, The Sven Lovén Centre for Marine Sciences, University of Gothenburg, Kristineberg, Sweden
    Ecotoxicology 19:449-62. 2010
  5. ncbi The oceanic sink for anthropogenic CO2
    Christopher L Sabine
    National Oceanic and Atmospheric Administration NOAA Pacific Marine Environmental Laboratory, 7600 Sand Point Way NE, Seattle, WA 98115, USA
    Science 305:367-71. 2004
  6. ncbi Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store
    Karthikeyan Narayanan
    Department of Oral Biology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:17500-8. 2003
  7. ncbi Long-term imatinib therapy promotes bone formation in CML patients
    Stephen Fitter
    Bone and Cancer Research Laboratories, and Division of Haematology, Institute of Medical and Veterinary Science IMVS, The Hanson Institute, Adelaide, SA 5000, Australia
    Blood 111:2538-47. 2008
  8. ncbi Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses
    M Amling
    Department of Trauma Surgery, Hamburg University School of Medicine, Germany
    Endocrinology 140:4982-7. 1999
  9. ncbi Proteins of calcified endoskeleton: II partial amino acid sequences of endoskeletal proteins and the characterization of proteinaceous organic matrix of spicules from the alcyonarian, Synularia polydactyla
    M Azizur Rahman
    Department of Marine and Environmental Sciences, University of the Ryukyus, Okinawa, Japan
    Proteomics 5:885-93. 2005
  10. ncbi Self-assembly and mineralization of peptide-amphiphile nanofibers
    J D Hartgerink
    Department of Materials Science and Engineering, Medical School, Northwestern University, 2225 North Campus Drive, Evanston, IL 60208, USA
    Science 294:1684-8. 2001

Research Grants

  1. Osteopontin: a Novel Biomarker for Calcific Aortic Valve Diseases
    Giovanni Ferrari; Fiscal Year: 2010
  2. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
  3. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
  4. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
  5. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
  6. Initiation and Inhibition of Medial Artery Calcification
    Paul Price; Fiscal Year: 2008
  7. MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    Paul Price; Fiscal Year: 2001
  8. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
  9. 5 LIPOXYGENASE IN BONE
    Lynda Bonewald; Fiscal Year: 2001
  10. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007

Detail Information

Publications232 found, 100 shown here

  1. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
    ..Our findings suggest a bone-renal axis that is central to guiding proper mineral metabolism...
  2. ncbi Impact of anthropogenic CO2 on the CaCO3 system in the oceans
    Richard A Feely
    Pacific Marine Environmental Laboratory, National Oceanic and Atmospheric Administration, Seattle, WA 98115 6349, USA
    Science 305:362-6. 2004
    ..The total water column CaCO3 dissolution rate for the global oceans is approximately 0.5 +/- 0.2 petagrams of CaCO3-C per year, which is approximately 45 to 65% of the export production of CaCO3...
  3. ncbi Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
    A R Hayman
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, UK
    Development 122:3151-62. 1996
    ....
  4. ncbi Impact of near-future ocean acidification on echinoderms
    S Dupont
    Department of Marine Ecology, The Sven Lovén Centre for Marine Sciences, University of Gothenburg, Kristineberg, Sweden
    Ecotoxicology 19:449-62. 2010
    ..g. pH, temperature, toxicants) and organism health. However, available data allow us to conclude that near-future OA will have negative impact on echinoderm taxa with likely significant consequences at the ecosystem level...
  5. ncbi The oceanic sink for anthropogenic CO2
    Christopher L Sabine
    National Oceanic and Atmospheric Administration NOAA Pacific Marine Environmental Laboratory, 7600 Sand Point Way NE, Seattle, WA 98115, USA
    Science 305:367-71. 2004
    ..The current fraction of total anthropogenic CO2 emissions stored in the ocean appears to be about one-third of the long-term potential...
  6. ncbi Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store
    Karthikeyan Narayanan
    Department of Oral Biology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:17500-8. 2003
    ..The data presented here represent a paradigm shift in the understanding of DMP1 function. This information is crucial in understanding normal bone formation, remodeling, fracture healing, and skeletal tissue repair...
  7. ncbi Long-term imatinib therapy promotes bone formation in CML patients
    Stephen Fitter
    Bone and Cancer Research Laboratories, and Division of Haematology, Institute of Medical and Veterinary Science IMVS, The Hanson Institute, Adelaide, SA 5000, Australia
    Blood 111:2538-47. 2008
    ..Further investigation is required to determine whether the increase in TBV associated with imatinib therapy may represent a novel therapeutic avenue for the treatment of diseases that are characterized by generalized bone loss...
  8. ncbi Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses
    M Amling
    Department of Trauma Surgery, Hamburg University School of Medicine, Germany
    Endocrinology 140:4982-7. 1999
    ..The skeletal consequences of VDR ablation are a result of impaired intestinal calcium absorption and/or the resultant secondary hyperparathyroidism and hypophosphatemia...
  9. ncbi Proteins of calcified endoskeleton: II partial amino acid sequences of endoskeletal proteins and the characterization of proteinaceous organic matrix of spicules from the alcyonarian, Synularia polydactyla
    M Azizur Rahman
    Department of Marine and Environmental Sciences, University of the Ryukyus, Okinawa, Japan
    Proteomics 5:885-93. 2005
    ..These findings suggest that the endoskeletal spicules of alcyonarian corals have protein-rich organic matrices, which might be related to the calcification process...
  10. ncbi Self-assembly and mineralization of peptide-amphiphile nanofibers
    J D Hartgerink
    Department of Materials Science and Engineering, Medical School, Northwestern University, 2225 North Campus Drive, Evanston, IL 60208, USA
    Science 294:1684-8. 2001
    ..This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone...
  11. pmc Retinoic acid stimulates annexin-mediated growth plate chondrocyte mineralization
    Wei Wang
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA
    J Cell Biol 157:1061-9. 2002
    ....
  12. ncbi Sponge paleogenomics reveals an ancient role for carbonic anhydrase in skeletogenesis
    Daniel J Jackson
    Geoscience Centre Göttingen, Department of Geobiology, Goldschmidtstrasse 3, D 37077 Gottingen, Germany
    Science 316:1893-5. 2007
    ....
  13. ncbi Mucins and molluscan calcification. Molecular characterization of mucoperlin, a novel mucin-like protein from the nacreous shell layer of the fan mussel Pinna nobilis (Bivalvia, pteriomorphia)
    F Marin
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Biol Chem 275:20667-75. 2000
    ....
  14. ncbi Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro
    Jonathan A R Gordon
    Department of Biochemistry and Division of Oral Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Bone 41:462-73. 2007
    ..These results demonstrate that BSP may serve as a matrix-associated signal directly promoting osteoblast differentiation resulting in the increased production of a mineralized matrix...
  15. ncbi Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells
    Mika Yamauchi
    Dept of Endocrinology, Metabolism, and Hematological Oncology, Shimane Univ School of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
    Am J Physiol Endocrinol Metab 288:E608-16. 2005
    ..This suggests that the CaR may be involved in osteoblastic differentiation...
  16. ncbi Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite
    Sivakumar Gajjeraman
    Department of Oral Biology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 282:1193-204. 2007
    ..Such understanding of biomolecule controls on biomineralization promises new insights into the controlled synthesis of crystalline structures...
  17. ncbi Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts
    Zhen Xiao
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    J Cell Physiol 210:325-35. 2007
    ..This investigation represents the first systematic proteomic analysis of MVs and provides insights into both the function and origin of these important mineralization-regulating vesicles...
  18. ncbi Inorganic pyrophosphate generation and disposition in pathophysiology
    R A Terkeltaub
    Veterans Affairs Medical Center and School of Medicine, University of California, San Diego, California 92161, USA
    Am J Physiol Cell Physiol 281:C1-C11. 2001
    ....
  19. ncbi Site-specific in vivo calcification and osteogenesis stimulated by bone sialoprotein
    Jinxi Wang
    Laboratory for the Study of Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Calcif Tissue Int 79:179-89. 2006
    ..These results demonstrate that BSP stimulates calcification and osteogenesis in a site-specific manner, and that local environment and the specificities of responding cells may play critical roles in the function of BSP in vivo...
  20. ncbi FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization
    L Darryl Quarles
    Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Endocrinol Metab 285:E1-9. 2003
    ....
  21. pmc Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization
    Lovisa Hessle
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:9445-9. 2002
    ..Our results suggest that inhibiting PC-1 function may be a viable therapeutic strategy for hypophosphatasia. Conversely, interfering with TNAP activity may correct pathological hyperossification because of PP(i) insufficiency...
  22. pmc Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone
    Monzur Murshed
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030, USA
    Genes Dev 19:1093-104. 2005
    ....
  23. ncbi Molecular cloning of a cDNA encoding a soluble protein in the coral exoskeleton
    Isao Fukuda
    Division of Marine Biosciences, Ocean Research Institute, The University of Tokyo, 1 15 1 Minamidai, Nakano, 168 8639, Tokyo, Japan
    Biochem Biophys Res Commun 304:11-7. 2003
    ..Galaxin exhibits a novel amino acid sequence which is characterized by a tandem repeat structure. Galaxin transcripts were detected in the adult coral, but not in planktonic larvae...
  24. pmc Extracellular matrix production and calcium carbonate precipitation by coral cells in vitro
    Yael Helman
    Environmental Biophysics and Molecular Ecology Program and Inorganic Analytical Laboratory, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, 71 Dudley Road, New Brunswick, NJ 08901, USA
    Proc Natl Acad Sci U S A 105:54-8. 2008
    ..Our results demonstrate the ability of isolated, differentiated coral cells to undergo fundamental processes required for multicellular organization...
  25. pmc Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals
    Despina Sitara
    Department of Developmental Biology, Harvard School of Dental Medicine, REB 303, 188 Longwood Ave, Boston, MA 02115, USA, and The Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
    Am J Pathol 169:2161-70. 2006
    ....
  26. ncbi The aminobisphosphonate risedronate preserves localized mineral and material properties of bone in the presence of glucocorticoids
    Guive Balooch
    Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Arthritis Rheum 56:3726-37. 2007
    ....
  27. pmc Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice
    H Clarke Anderson
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Pathol 164:841-7. 2004
    ..Thus, with TNAP deficiency a buildup of mineral-inhibiting PPi would be expected at the perimeter of MVs...
  28. pmc Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders
    Dympna Harmey
    The Burnham Institute, La Jolla, CA 92037, USA
    Am J Pathol 164:1199-209. 2004
    ..The hypomineralization observed in Akp2(-/-) mice arises from the combined inhibitory effects of PP(i) and OPN. In contrast, NPP1 or ANK deficiencies cause a decrease in the PP(i) and OPN pools that leads to hypermineralization...
  29. ncbi Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat
    Hoa Ton Kha
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Bone Miner Res 19:830-40. 2004
    ..Such effects may have important implications for intervention with osteoporosis...
  30. ncbi The degree of mineralization is a determinant of bone strength: a study on human calcanei
    H Follet
    Laboratoire de Mécanique des Contacts et des Solides LaMCoS, UMR 5514, INSA, Lyon, France
    Bone 34:783-9. 2004
    ..The impact of such modifications on fracture risk and the therapeutic implications of these data remain to be analyzed...
  31. ncbi Structure and expression of an unusually acidic matrix protein of pearl oyster shells
    Daiki Tsukamoto
    Department of Earth and Planetary Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 320:1175-80. 2004
    ..Our findings and previous in vitro experiments taken together suggest that Aspein is responsible for directed formation of calcite in the shell of the pearl oyster Pinctada fucata...
  32. ncbi Metastatic breast cancer cells suppress osteoblast adhesion and differentiation
    Robyn R Mercer
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA
    Clin Exp Metastasis 21:427-35. 2004
    ..These affects could account for the continued loss of bone after osteoclast inhibition in patients with bone-metastatic breast cancer...
  33. ncbi Low temperature FESEM of the calcifying interface of a scleractinian coral
    P L Clode
    Analytical Electron Microscopy Laboratory, Department of Zoology, La Trobe University, Bundoora, VIC 3083, Australia
    Tissue Cell 34:187-98. 2002
    ..A thin sheath was also frequently observed adjacent to the apical membrane of calicoblastic cells...
  34. ncbi Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells
    Hideaki Sowa
    Third Department of Medicine, Kobe University School of Medicine, Japan
    J Bone Miner Res 17:1190-9. 2002
    ..We propose that Smad3 plays an important role in osteoblastic bone formation and might help to elucidate the transcriptional mechanism of bone formation and possibly lead to the development of bone-forming drugs...
  35. ncbi Inducers and inhibitors of biomineralization: lessons from pathological calcification
    C M Giachelli
    Department of Bioengineering, University of Washington, Seattle, 98195, USA
    Orthod Craniofac Res 8:229-31. 2005
    ..Over the past several years, we have developed in vitro and in vivo models of ectopic calcification to investigate potential inducers and inhibitors of this process...
  36. ncbi Cissus quadrangularis extract enhances biomineralization through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblasts
    Duenpim Parisuthiman
    Faculty of Dentistry, Thammasat University, 99 Moo 18, Paholyothin Rd, Klong Luang, Pathumthani, 12121, Thailand
    In Vitro Cell Dev Biol Anim 45:194-200. 2009
    ..These results suggested that CQ-E may regulate osteoblastic activity by enhancing ALP activity and mineralization process, and the increased ALP activity effect of CQ-E is likely mediated by MAPK-dependent pathway...
  37. ncbi Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice
    Dympna Harmey
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Bone Miner Res 21:1377-86. 2006
    ..We also found that extracellular OPN regulates the PP(i) output by osteoblasts...
  38. ncbi Bone mineral and collagen quality in iliac crest biopsies of patients given teriparatide: new results from the fracture prevention trial
    Eleftherios P Paschalis
    Mineralized Tissue Section, Research Division, The Hospital for Special Surgery, New York, New York 10021, USA
    J Clin Endocrinol Metab 90:4644-9. 2005
    ..Matrix mineralization, hydroxyapatite characteristics, and collagen cross-link ratio are key determinants of material properties. Fourier transform infrared imaging (FTIRI) yields data on these characteristics from bone sections...
  39. ncbi Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage
    T Kirsch
    Department of Anatomy Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Osteoarthritis Cartilage 8:294-302. 2000
    ..To test the hypothesis that terminal differentiation of chondrocytes in human osteoarthritic cartilage might lead to the failure of repair mechanisms and might cause progressive loss of structure and function of articular cartilage...
  40. ncbi The effect of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnover
    Babul Borah
    Procter and Gamble Pharmaceuticals, Inc, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA
    Bone 37:1-9. 2005
    ..The results demonstrate that the reduction of turnover by risedronate increased the degree of mineralization and reduced the ratio of low- to high-mineralized bone fractions which may increase bone's resistance to fracture...
  41. pmc The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged estrogen-deficient rats and is a strong predictor of bone strength
    Wei Yao
    Department of Medicine, Aging Center, UC Davis Medical Center, Sacramento, CA 95817, USA
    Bone 41:804-12. 2007
    ....
  42. ncbi Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation
    O Fromigue
    INSERM Unit 349, Cell and Molecular Biology of Bone and Cartilage, Lariboisiere Hospital, Paris, France
    J Cell Biochem 68:411-26. 1998
    ..These observations suggest that TGF-beta2 and BMP-2 may act in a sequential manner at different stages to promote human bone marrow stromal cell differentiation towards the osteoblast phenotype...
  43. ncbi Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: sequential triple biopsy studies with micro-computed tomography
    B Borah
    Procter and Gamble Pharmaceuticals, Inc Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA
    Bone 39:345-52. 2006
    ..Overall, risedronate provided sustained benefits on mineralization and architecture, two key determinants of bone strength, over 5 years lending support for its long-term efficacy in fracture risk reduction...
  44. ncbi Histomorphometric evidence for increased bone turnover without change in cortical thickness or porosity after 2 years of cyclical hPTH(1-34) therapy in women with severe osteoporosis
    A B Hodsman
    Department of Medicine and Lawson Research Institute, University of Western Ontario, London, ON, Canada
    Bone 27:311-8. 2000
    ....
  45. ncbi Effects of ibandronate on bone quality: preclinical studies
    F Bauss
    Department of Pharmacology, Roche Diagnostics GmbH, Pharma Research Penzberg, Nonnenwald 2, Building 231 Room 579, D 82377 Penzberg, Germany
    Bone 40:265-73. 2007
    ..This review describes the preclinical evidence for the preservation of bone quality with ibandronate, irrespective of the dosing regimen and even when administered at doses higher than those used therapeutically...
  46. ncbi Bone material properties in trabecular bone from human iliac crest biopsies after 3- and 5-year treatment with risedronate
    Erich Durchschlag
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria
    J Bone Miner Res 21:1581-90. 2006
    ..This effect may be contributing to risedronate's antifracture efficacy...
  47. ncbi The two-step mode of growth in the scleractinian coral skeletons from the micrometre to the overall scale
    Jean Pierre Cuif
    UMR 8148 IDES, Geology, Bat 504, Université Paris XI Orsay, F 91405 Orsay cedex, France
    J Struct Biol 150:319-31. 2005
    ..Clearly, at the overall ontogenic level, the two-step growth mode of coral skeletons is also a valuable tool to reconstruct the evolutionary history of Scleractinia...
  48. ncbi Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression
    Xiuying Bai
    Division of Endocrinology, Department of Medicine, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Sainte Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Mol Endocrinol 16:2913-25. 2002
    ....
  49. ncbi Raloxifene and teriparatide (hPTH 1-34) have complementary effects on the osteopenic skeleton of ovariectomized rats
    Yanfei L Ma
    Lilly Research Laboratories, Lilly Corporate Center, Bldg 98C B, DC 0403, Indianapolis, IN 46285, USA
    J Bone Miner Metab 23:62-8. 2005
    ..Raloxifene inhibited bone resorption, and reduced high bone turnover without significantly retarding TPTD stimulation of bone formation activity...
  50. ncbi Bone metabolism and bone mineral density in childhood hypophosphatasia
    H J Girschick
    Children s Hospital, University of Wurzburg, Germany
    Bone 25:361-7. 1999
    ..Hypermineralization/sclerosis of trabecular bone might serve as a compensation for a mechanically incompetent bony structure due to an impaired mineralization of cartilage caused by the genetic deficiency of alkaline phosphatase...
  51. ncbi Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women
    P Roschger
    Ludwig Boltzmann Institute of Osteology, Fourth Medical Department, Hanusch Krankenhaus and Unfallkrankenhaus Meidling, Vienna, Austria
    Bone 29:185-91. 2001
    ..It also decreases the porosity of the corticalis. Together these effects may contribute to the observed reduction in fractures...
  52. ncbi Effects of 3- and 5-year treatment with risedronate on bone mineralization density distribution in triple biopsies of the iliac crest in postmenopausal women
    Ruth Zoehrer
    Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Vienna, Austria
    J Bone Miner Res 21:1106-12. 2006
    ..These changes at the material level of bone could contribute to risedronate's antifracture efficacy...
  53. ncbi Purification of a soluble glycoprotein from the uncalcified ecdysial cuticle of the blue crab Callinectes sapidus and its possible role in initial mineralization
    Elizabeth P Tweedie
    Department of Biological Sciences, University of North Carolina at Wilmington, Wilmington, NC, USA
    J Exp Biol 207:2589-98. 2004
    ..This strengthens the hypothesis that the glycoprotein under investigation is an inhibitor of calcite nucleation or of initial amorphous calcium carbonate accumulation...
  54. ncbi Transient precursor strategy in mineral formation of bone
    Steve Weiner
    Bone 39:431-3. 2006
    ..Bone (In press), using micro-Raman spectroscopy to study early mineral deposits in mice calvaria, provides strong evidence that the transient precursor strategy also occurs in vertebrates...
  55. ncbi Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein family
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Exp Zool B Mol Dev Evol 306:295-316. 2006
    ..Thus, the evolution of vertebrate mineralized tissues seems to be explained by phenogenetic drift: while mineralized tissues are retained during vertebrate evolution, the underlying genetic basis has extensively drifted...
  56. ncbi Transient precursor strategy or very small biological apatite crystals?
    Marc D Grynpas
    Bone 41:162-4. 2007
    ....
  57. ncbi The role of matrix vesicles in growth plate development and biomineralization
    H Clarke Anderson
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA lt
    Front Biosci 10:822-37. 2005
    ....
  58. ncbi Ovalbumin is a component of the chicken eggshell matrix
    M T Hincke
    Department of Anatomy and Neurobiology, University of Ottawa, Ottawa, Canada
    Connect Tissue Res 31:227-33. 1995
    ..However, it is not yet clear whether ovalbumin at this site plays a specific role in shell mineralization...
  59. ncbi Cloning of ovocalyxin-36, a novel chicken eggshell protein related to lipopolysaccharide-binding proteins, bactericidal permeability-increasing proteins, and plunc family proteins
    Joel Gautron
    Institut National de la Recherche Agronomique, UR83 Unité de Recherches Avicoles, F 37380 Nouzilly, France
    J Biol Chem 282:5273-86. 2007
    ..OCX-36 may therefore participate in natural defense mechanisms that keep the egg free of pathogens...
  60. pmc Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice
    H Clarke Anderson
    Dept of Pathology and Lab Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Pathol 166:1711-20. 2005
    ..Thus, the osteomalacia of Akp2-/- mice and the hypomineralized phenotype of the long bones of Enpp1-/- mice are not rescued by simultaneous deletion of TNAP and NPP1 functions...
  61. ncbi Study of calcification during a daily cycle of the coral Stylophora pistillata: implications for 'light-enhanced calcification'
    Aurélie Moya
    Centre Scientifique de Monaco, Avenue Saint Martin, MC 98000 Principality of Monaco
    J Exp Biol 209:3413-9. 2006
    ....
  62. ncbi The carbonic anhydrase domain protein nacrein is expressed in the epithelial cells of the mantle and acts as a negative regulator in calcification in the mollusc Pinctada fucata
    Hiroshi Miyamoto
    Faculty of Biology Oriented Science and Technology, Department of Molecular Genetics, Kinki University, Uchita, Wakayama, Japan
    Zoolog Sci 22:311-5. 2005
    ..Together these studies suggest that nacrein functions as a negative regulator in calcification in the extrapallial space between the shell and the mantle by inhibiting the precipitation of CaCO3...
  63. ncbi A comparative analysis of strategies for isolation of matrix vesicles
    M Balcerzak
    Department of Cellular Biochemistry, Nencki Insitute of Experimental Biology, Polish Academy of Sciences, 02 093 Warsaw, Poland
    Anal Biochem 361:176-82. 2007
    ....
  64. ncbi Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization
    Scott Roberts
    Bone Biology Group, Roslin Institute, Edinburgh, Scotland, UK
    J Bone Miner Res 22:617-27. 2007
    ..PHOSPHO1 expression was present within matrix vesicles, and inhibition of enzyme action caused a decrease in the ability of matrix vesicles to calcify...
  65. pmc DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis
    Yunfeng Ling
    Musculoskeletal Integrity Program, Hospital for Special Surgery, New York, New York, USA
    J Bone Miner Res 20:2169-77. 2005
    ..The observed decreased mineral content in dmp1 null mice indicates a key role for dmp1 in bone mineralization. Indirect effects of DMP1 on other systems also determine the KO phenotype...
  66. ncbi Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate
    Patrik Lundquist
    Institute for Physiology and Center for Integrative Human Physiology, University of Zurich, Switzerland
    Cell Physiol Biochem 19:43-56. 2007
    ..Their expression thus seem regulated by phosphate in a manner consistent with their playing a role in transcellular P(i) flux during mineralization...
  67. ncbi Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity
    William N Addison
    Faculty of Dentistry, McGill University, Montreal, Quebec H3A 2B2, Canada
    J Biol Chem 282:15872-83. 2007
    ..In summary, PP(i) prevents mineralization in MC3T3-E1 osteoblast cultures by at least three different mechanisms that include direct binding to growing crystals, induction of Opn expression, and inhibition of Tnap activity...
  68. ncbi Proteomic analysis of the acid-soluble organic matrix of the chicken calcified eggshell layer
    Karlheinz Mann
    Max Planck Institut fur Biochemie, Abteilung für Proteomics und Signaltransduktion, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Proteomics 6:3801-10. 2006
    ....
  69. ncbi Calcium associated with a fibrillar organic matrix in the scleractinian coral Galaxea fascicularis
    P L Clode
    Analytical Electron Microscopy Laboratory, Department of Zoology, La Trobe University, Melbourne, Victoria
    Protoplasma 220:153-61. 2003
    ..This arrangement conforms with the criteria necessary for biomineralisation and with the long-held theory that organic matrices may act as templates for crystal formation and growth in biological mineralising systems...
  70. ncbi Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2/Cbfal
    Benjamin A Byers
    Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, USA
    J Bone Miner Res 17:1931-44. 2002
    ..These results suggest that, although functional Runx2 is essential to multiple osteoblast-specific activities, in vitro matrix mineralization requires additional tissue-specific cofactors, which supplement Runx2 activity...
  71. ncbi Construction of an alkaline phosphatase-liposome system: a tool for biomineralization study
    Fernando L Camolezi
    Departamento de Quimica, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto FFCLRP USP, SP, Brazil
    Int J Biochem Cell Biol 34:1091-101. 2002
    ..The standardization of such system allows the study of the effect of phospholipids and the enzyme in in vitro and in vivo mineralization, since it reproduces many essential features of the matrix vesicle...
  72. ncbi Phytoplankton calcification in a high-CO2 world
    M Debora Iglesias-Rodriguez
    National Oceanography Centre, Southampton, University of Southampton Waterfront Campus, European Way, Southampton SO14 3ZH, UK
    Science 320:336-40. 2008
    ..Our findings show that coccolithophores are already responding and will probably continue to respond to rising atmospheric CO2 partial pressures, which has important implications for biogeochemical modeling of future oceans and climate...
  73. ncbi Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype
    Shiguang Liu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:3686-97. 2002
    ....
  74. ncbi Effects of exogenous N-acetylhexosaminidase on the structure and mineralization of the post-ecdysial exoskeleton of the blue crab, Callinectes sapidus
    D C Pierce
    Department of Biological Sciences, University of North Carolina at Wilmington, 601 South College Road, Wilmington, NC 28403-3297, USA
    Comp Biochem Physiol B Biochem Mol Biol 128:691-700. 2001
    ..The data imply a role of the cuticular HexNAcase-like enzyme in the initiation of calcite nucleation in the newly formed exoskeleton...
  75. ncbi Bone mineral acquisition in healthy Asian, Hispanic, black, and Caucasian youth: a longitudinal study
    L K Bachrach
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5208, USA
    J Clin Endocrinol Metab 84:4702-12. 1999
    ..Black and Asian females and Asian males tended to reach a plateau in BMD earlier than the other ethnic groups. The use of gender- and ethnic-specific standards is recommended when interpreting pediatric bone densitometry data...
  76. ncbi Molecular cloning and ultrastructural localization of the core protein of an eggshell matrix proteoglycan, ovocleidin-116
    M T Hincke
    Department of Cellular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 274:32915-23. 1999
    ..Ovocleidin-116 thus is a candidate molecule for the regulation of calcite growth during eggshell calcification...
  77. ncbi Spatiotemporal assessment of fetal bovine osteoblast culture differentiation indicates a role for BSP in promoting differentiation
    L F Cooper
    Department of Prosthodontics, University of North Carolina School of Dentistry, Chapel Hill 27599 7450, USA
    J Bone Miner Res 13:620-32. 1998
    ..Matrix protein-cell interactions may be examined using this spatiotemporally defined model...
  78. ncbi Cloning and targeted deletion of the mouse fetuin gene
    W Jahnen-Dechent
    Institut für Physiologische Chemie und Pathobiochemie, Johannes Gutenberg Universitat, Duesbergweg 6, D 55099 Mainz, Federal Republic of Germany
    J Biol Chem 272:31496-503. 1997
    ..These results corroborate a role for fetuin in serum calcium homeostasis. The fact that generalized ectopic calcification did not occur in fetuin-deficient mice proves that additional inhibitors of phase separation exist in serum...
  79. ncbi Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia
    S Narisawa
    The Burnham Institute, La Jolla Cancer Research Center, California 92037, USA
    Dev Dyn 208:432-46. 1997
    ..5 and E13.5 of embryogenesis. We hypothesize that the autonomic nervous system is compromised in these TNAP-/- mice...
  80. ncbi The carboxyl-terminal domain of phosphophoryn contains unique extended triplet amino acid repeat sequences forming ordered carboxyl-phosphate interaction ridges that may be essential in the biomineralization process
    A George
    Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 271:32869-73. 1996
    ..These two domains and the colocalization of Dmp1 and Dmp2 genes at a position equivalent to the dentinogenesis imperfecta type II location on human 4q21 all suggest that the PPs are indeed involved in some aspect of ECM mineralization...
  81. ncbi Evidence of the presence of a specific ATPase responsible for ATP-initiated calcification by matrix vesicles isolated from cartilage and bone
    H H Hsu
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160 7410, USA
    J Biol Chem 271:26383-8. 1996
    ....
  82. ncbi Bone-like nodules formed by human bone marrow stromal cells: comparative study and characterization
    N Schecroun
    Orthopaedic Research Laboratory, Avenue Mounier, 53, Universite Catholique de Louvain, B 1200, Brussels, Belgium
    Bone 32:252-60. 2003
    ..Thus, this differentiation model could provide a new tool to elaborate an autologous cell therapy designed to enhance osteogenesis...
  83. ncbi Altered pH regulation during enamel development in the cystic fibrosis mouse incisor
    W Sui
    Department of Pediatric Dentistry, Brauer Hall CB 7450, School of Dentistry, University of North Carolina, Chapel Hill 27599 7450, USA
    J Dent Res 82:388-92. 2003
    ..These results indicate that CFTR plays a role in pH regulation during enamel development and that a reduced pH results in a lack of calcium influx during enamel maturation and hypomineralization of the CF incisor enamel...
  84. ncbi Bone acidic glycoprotein-75 delineates the extracellular sites of future bone sialoprotein accumulation and apatite nucleation in osteoblastic cultures
    Ronald J Midura
    Department of Biomedical Engineering and The Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic and Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 279:25464-73. 2004
    ..Furthermore, we propose a hypothetical mechanism in which BAG-75 and BSP function actively in nucleation of apatite within BMF...
  85. ncbi Extracellular bone acidic glycoprotein-75 defines condensed mesenchyme regions to be mineralized and localizes with bone sialoprotein during intramembranous bone formation
    Jeff P Gorski
    Division of Biochemistry and Molecular Biology, School of Biological Sciences, School of Dentistry, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    J Biol Chem 279:25455-63. 2004
    ....
  86. ncbi Molecular analyses of protein components of the organic matrix in the exoskeleton of two scleractinian coral species
    Toshiki Watanabe
    Division of Marine Bioscience, Ocean Research Institute, The University of Tokyo, 1 15 1 Minamidai, Nakano, Tokyo 164 8639, Japan
    Comp Biochem Physiol B Biochem Mol Biol 136:767-74. 2003
    ..Preliminary characterization of the T. aurea proteins showed that two proteins bound Ca(2+), and suggested that the major protein of 46 kDa was not homologous to galaxin...
  87. ncbi Increased bone formation in osteocalcin-deficient mice
    P Ducy
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 382:448-52. 1996
    ..To our knowledge, this study provides the first evidence that osteocalcin is a determinant of bone formation...
  88. ncbi Molluscan shell proteins: primary structure, origin, and evolution
    Frederic Marin
    UMR CNRS 5561 Biogeosciences, Université de Bourgogne 6 Boulevard Gabriel, 21000 Dijon, France
    Curr Top Dev Biol 80:209-76. 2008
    ..Consequently, the molluscan shell matrix may be a source of bioactive molecules that would offer interesting perspectives in biomaterials and biomedical fields...
  89. ncbi Inorganic phosphate as a signaling molecule in osteoblast differentiation
    George R Beck
    National Cancer Institute at Frederick, Center for Cancer Research, Basic Research Laboratory, Frederick, Maryland 21702, USA
    J Cell Biochem 90:234-43. 2003
    ..The regulation of protein function and gene expression by elevated inorganic phosphate during osteoblast differentiation may represent a mechanism by which mineralizing cells monitor and respond to the changing extracellular environment...
  90. ncbi Collagen XXIV (Col24a1) gene expression is a specific marker of osteoblast differentiation and bone formation
    Noritaka Matsuo
    Laboratory of Genetics and Organogenesis, Research Division of the Hospital for Special Surgery, New York, New York, USA
    Connect Tissue Res 49:68-75. 2008
    ..These findings lend further support to the hypothesis that collagen XXIV may be implicated in the formation of a mineralization-competent bone matrix...
  91. ncbi Osteoblast differentiation is enhanced in rotary cell culture simulated microgravity environments
    Y Joon Ko
    Department of Prosthodontics, College of Dentistry, University of Iowa, Iowa City, IA, USA
    J Prosthodont 16:431-8. 2007
    ..The objective of this study was to test the hypothesis that 3D rotary cell culture (RCC) environments created by simulated microgravity would enhance osteogenic gene expression using integrin mediated pathways...
  92. ncbi Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralization
    Akemichi Ueno
    Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Cell Physiol 209:322-32. 2006
    ..These results indicate that TSP1 functions as an inhibitory regulator of bone mineralization and matrix production by osteoblasts to sustain bone homeostasis...
  93. ncbi Increased levels of xylosyltransferase I correlate with the mineralization of the extracellular matrix during osteogenic differentiation of mesenchymal stem cells
    Benjamin Müller
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabesteszentrum NRW, Universitatsklinik der Ruhr Universitat Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany
    Matrix Biol 27:139-49. 2008
    ..The synchronized expression profiles demonstrate the coordinated biosynthesis of the PGs during bone formation and osteogenic stem cell differentiation occurring in parallel to the mineralization of the extracellular matrix...
  94. ncbi HIV proteins regulate bone marker secretion and transcription factor activity in cultured human osteoblasts with consequent potential implications for osteoblast function and development
    Eoin J Cotter
    General Clinical Research Unit, School of Medicine and Medical Sciences, University College Dublin, Ireland
    AIDS Res Hum Retroviruses 23:1521-30. 2007
    ..HIV proteins can potentially modulate OB development and function in vitro via modulation of bone maker secretion and RUNX-2 and PPARgamma transcription factor activity...
  95. ncbi Effects of zinc on the mineralization of bone nodules from human osteoblast-like cells
    Aleksandra Cerovic
    Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
    Biol Trace Elem Res 116:61-71. 2007
    ..These findings demonstrate that zinc has biphasic effects on the differentiation and mineralization of human osteoblast-like cells...
  96. pmc Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone
    Melita M Dvorak
    Cardiff University School of Biosciences, UK
    J Am Soc Nephrol 18:2509-16. 2007
    ..Therefore, in addition to their use as antihypertensive drugs, our results suggest that thiazides may find a role in the prevention and treatment of osteoporosis...
  97. ncbi Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and BMP2
    Xiaoling Zhang
    Joint Orthopaedic Laboratory of Institute of Health Sciences and Shanghai Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai, People s Republic of China
    J Orthop Res 26:314-21. 2008
    ....
  98. ncbi Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose--derived stem cells in vitro and in vivo
    X Zhang
    Department of Sports Medicine, Peking University Third Hospital, Beijing 100083, China
    Calcif Tissue Int 79:169-78. 2006
    ..Our work demonstrates a potential new approach for bone repair using Runx2-modified ADSCs for bone tissue engineering...
  99. ncbi L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitro
    S Colucci
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Calcif Tissue Int 76:458-65. 2005
    ..In conclusion these data suggest that carnitine and, in particular, its new derivative, Iso-V-LC supplementation in the elderly may stimulate osteoblast activity and decrease age-related bone loss...
  100. ncbi Inductive effects of dexamethasone on the mineralization and the osteoblastic gene expressions in mature osteoblast-like ROS17/2.8 cells
    Yoshikazu Mikami
    Department of Anatomy, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Biochem Biophys Res Commun 362:368-73. 2007
    ....
  101. ncbi Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo
    Ming K Chang
    Institute for Molecular Bioscience, Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland, Brisbane, Queensland, Australia
    J Immunol 181:1232-44. 2008
    ..These observations implicate OsteoMacs, in addition to osteoclasts and osteoblasts, as principal participants in bone dynamics...

Research Grants63

  1. Osteopontin: a Novel Biomarker for Calcific Aortic Valve Diseases
    Giovanni Ferrari; Fiscal Year: 2010
    ..We propose a translational research study aim to characterize tissue- and blood-derived osteopontin as a predictor for the degree and progression of aortic valve calcification ..
  2. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
    ..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
  3. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  4. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  5. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
    ....
  6. Initiation and Inhibition of Medial Artery Calcification
    Paul Price; Fiscal Year: 2008
    ..abstract_text> ..
  7. MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    Paul Price; Fiscal Year: 2001
    ..The investigators will further study the demonstrated ability of MGP to inhibit calcification in supersaturated solutions, and will investigate the ability of MGP to inhibit matrix vesicle -initiated calcification. ..
  8. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
    ..New knowledge of matrix vesicle calcification can be applied to a broad range of topics including specific diseases in which abnormal calcification occurs. ..
  9. 5 LIPOXYGENASE IN BONE
    Lynda Bonewald; Fiscal Year: 2001
    ..Hence, these studies may also have profound implications for the increasing number of asthmatic patients who are currently being treated with steroids and 5LO inhibitors. ..
  10. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  11. Common Mediators of Vascular Calcification and Bone Dis*
    Cecilia Giachelli; Fiscal Year: 2004
    ..Aim 3 will determine the effect of hyperlipidemia on cartilaginous metaplasia, vascular calcification and osteoporosis in a mouse model of atherosclerosis...
  12. STRUCTURAL STUDIES OF MATRIX PROTEINS IN TEETH AND BONES
    STEPHEN WEINER; Fiscal Year: 2007
    ..abstract_text> ..
  13. MECHANISM FOR BONE SIALOPROTEIN TO NUCLEATE BIOAPATITE
    RONALD MIDURA; Fiscal Year: 2002
    ..abstract_text> ..
  14. MECHANISM OF MATRIX VESICLE BIOGENESIS
    Ellis Golub; Fiscal Year: 2004
    ..This information is crucial for developing new approaches to metabolic bone diseases such as Pagets's disease of bone and osteoporosis, and may also contribute to novel therapies for the repair of craniofacial defects and fracture. ..
  15. Calcium Absorption and Bone Formation During Puberty
    Steven Abrams; Fiscal Year: 2005
    ....
  16. MINERALIZATION OF PRIMARY BONE
    JEFFREY GORSKI; Fiscal Year: 2008
    ..Results of this work should better define the differences between primariy and lamellar bone, as well as aid in the diagnosis and treatment of osteoporosis and atherosclerosis. ..
  17. BAG-75: UNIQUE MARKER OF PRIMARY BONE FORMATION
    JEFFREY GORSKI; Fiscal Year: 2003
    ..Stimulation of appositional formation by lamellar bone would not be expected to have the same effect. These future functional studies require determination of the BAG-75 cDNA sequence. ..
  18. ROLES OF BMP4 & ITS REGULATION DURING TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2003
    ..Research into this relatively unexplored area will contribute to our understanding of the basic Msx1- Bmp4 signal pathway, mechanisms of tooth formation, and possible cause of autosomal dominant forms of familial tooth agenesis. ..
  19. Inflammation, the metabolic syndrome and atherosclerosis
    Muredach Reilly; Fiscal Year: 2006
    ..abstract_text> ..
  20. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2008
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  21. SYNTHESIS OF OSTEOCALCIN IN BONE
    Jane Lian; Fiscal Year: 2006
    ..These studies will establish the importance of bone selective transcription factor complexes for formation, maintenance and remodeling of bone tissue. ..
  22. Bioengineering Annulus Fibrosus using Silk Scaffold
    Rita Kandel; Fiscal Year: 2006
    ..The viability and mechanical properties of the tissue will be evaluated. ..
  23. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2006
    ..There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. [unreadable] [unreadable] [unreadable] [unreadable]..
  24. DENTIN BIOMINERALIZATION
    Charles Sfeir; Fiscal Year: 2007
    ..This data will also provide basic knowledge for designing treatment of ectopic mineralization specifically in diseases as such kidney stones or failing heart valve prosthesis. ..
  25. WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH
    Sarah E Millar; Fiscal Year: 2010
    ..abstract_text> ..
  26. A BABOON MODEL FOR THE GENETICS OF CORTICAL BONE MATERIAL PROPERTIES
    LORENA HAVILL; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. RANKL/OPG-Mediated Control of Vascular Calcification
    Linda L Demer; Fiscal Year: 2010
    ..Based on new supportive evidence, this research will test whether specific regulatory factors that promote loss of mineral from bone also promote gain of mineral in the artery wall. ..
  28. Genes Controlling the Renal Handling of Phosphate
    Ralph Meyer; Fiscal Year: 2004
    ..Such intervention may improve the skeletal symptoms of patients with hypophosphatemic bone disease and improve their quality of life. ..
  29. ROLES OF BMP4 AND ITS REGULATION IN TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2004
    ..Molecular techniques include RT-PCR, in situ hybridization, DNA sequence determination, SSCP (single strand conformational polymorphism), and heteroduplex analysis. ..
  30. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  31. S100A4: A Novel Regulator of Biomineralization
    WAGNER DUARTE; Fiscal Year: 2003
    ..The combination of this in vitro/in vivo approach would provide insights into the potential regulatory roles of S1004A4 in osteoblast differentiation and biomineralization. ..
  32. MRI Visceral Adipose Tissue Partitioning:Advanced Models
    Steven Heymsfield; Fiscal Year: 2005
    ..Our findings could help to set new standards for VAT and adipose tissue subcompartment measurement, lower the cost of MRI body composition studies, and improve study power. ..
  33. PTH and Mineralization: Role of Matrix Gla Protein
    Rajaram Gopalakrishnan; Fiscal Year: 2005
    ..abstract_text> ..
  34. GLUCOCORTICOID-INDUCED OSTEOPENIA IN CHILDREN
    Mary Leonard; Fiscal Year: 2005
    ..The accurate characterization of GC and disease effects on skeletal development is necessary to identify and evaluate targeted therapies to optimize skeletal architecture and peak bone mass in childhood. ..
  35. Multidiscipli. GCRC-Mentorship Program in Womens Health
    Lorraine Fitzpatrick; Fiscal Year: 2003
    ..abstract_text> ..
  36. INTERDISCIPLINARY RESEARCH PROGRAM FOR UNDERGRADUATES
    Clinton Rubin; Fiscal Year: 2004
    ..Indeed, it is hoped that the most successful of these students will enter our own graduate training programs in the biomedical sciences. ..
  37. MOLECULAR BASIS OF CALCIUM PYROPHOSPHATE DEPOSITION
    Ikuko Masuda; Fiscal Year: 2002
    ..It is hoped that these studies will lead to therapies to reduce ePPi accumulation and reduce subsequent cartilage degeneration. ..
  38. Magnesium Deficiency: Effect on Bone and Mineral
    Robert Rude; Fiscal Year: 2004
    ..These studies should substantiate our hypothesis that Mg depletion contributes to osteoporosis and provide mechanistic explanations. ..
  39. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2008
    ..abstract_text> ..
  40. LECTIN-LIKE PROPERTIES OF AMELOGENINS
    RAJESWARI RAVINDRANATH; Fiscal Year: 2004
    ..These experiments are a logical extension of the newly identified lectin-like properties of amelogenins (Ravindranath et al. Submitted), which are postulated to play a functional role in normal enamel biomineralization. ..
  41. A gene-trap screen for hearing and balance
    DONNA FEKETE; Fiscal Year: 2008
    ..Our long-term goal is to determine whether any of the newly discovered hearing-related genes in zebrafish also correspond to genes underlying congenital deafness in humans. [unreadable] [unreadable] [unreadable]..
  42. Genetics of atherosclerosis in renal disease
    Muredach P Reilly; Fiscal Year: 2010
    ....
  43. A MECHANISTIC STUDY OF SKELETAL ACTIONS OF 1-34hPTH
    Robert Lindsay; Fiscal Year: 2009
    ..abstract_text> ..
  44. Mineralization: Integrins and Focal Adhesion Kinase
    Galen Schneider; Fiscal Year: 2003
    ..This will allow for development of new therapeutic approaches that in turn could lead to novel treatments and tissue-engineered biological applications to increase the quality of life for many patients. ..
  45. Spectroscopic identification /removal of PMMA from bone
    Nancy Pleshko; Fiscal Year: 2005
    ....
  46. 4th International Conference on Children's Bone Health
    Mary Leonard; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  47. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    Renny Franceschi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  48. REGULATION OF BETA-CATENIN NUCLEARIZATION
    CHARLES ETTENSOHN; Fiscal Year: 2006
    ..In addition, using dominant negative constructs and morpholinos, we will examine the developmental function of two regulators of GSK3 activity, disheveled and Akt/PKB. ..
  49. Increasing physical activity of sedentary youth
    JAMES ROEMMICH; Fiscal Year: 2005
    ..This study will yield important information on new ways to increase the physical activity of children. ..
  50. MUSCULOSKELETAL TRAINING GRANT
    David Burr; Fiscal Year: 2006
    ..Two presentations were nominated for Young Investigator Awards by the ASBMR and the ORS. ..
  51. NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASE
    MARK HAUSSLER; Fiscal Year: 2007
    ..abstract_text> ..
  52. A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATION
    JANET OLDAK; Fiscal Year: 2004
    ..abstract_text> ..
  53. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  54. Gene-Augmented Mesenchymal Stem Cells in Bone Repair
    Terri Zachos; Fiscal Year: 2006
    ..We hypothesize that gene delivery of two different BMPs will result in accelerated healing of fractures, but by different mechanisms, confirmed by the production of unique cartilage- and bone-specific messages. [unreadable] [unreadable]..
  55. BIOMIMETIC SCAFFOLD FOR BONE-REPAIR
    Anne George; Fiscal Year: 2007
    ..abstract_text> ..
  56. Synchrotron-Based Infrared Microscope for Chemical Imaging of Disease
    Lisa Miller; Fiscal Year: 2007
    ..This instrument will be unique worldwide. [unreadable] [unreadable] [unreadable]..
  57. Lipid Regulation of Vascular and Bone Osteoclastogenesis
    Linda Demer; Fiscal Year: 2004
    ....
  58. Structural Bone Disease in Chronic Renal Insufficiency
    Mary Leonard; Fiscal Year: 2007
    ..Accurate characterization of bone structure in CRI is necessary to identify risk factors for fragility, and to evaluate potential therapies. ..
  59. A Critical Role of DMP-1 in Mineralization
    Jian Feng; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. Integrated Tomosynthetic Perfusion and Cone-beam CT Imaging on a C-arm Gantry
    Guang Hong Chen; Fiscal Year: 2009
    ..The new interventional platform will not only benefit those at researchcenters,but also will enable image-guided interventional stroke treatmentsfor hospitals without advanced imaging facilities. ..
  61. 3D Time-resolved Tomographic Interventional Platform
    Guang Hong Chen; Fiscal Year: 2004
    ....
  62. Persistent changes in brain expression after withdrawal
    KRISTINE WIREN; Fiscal Year: 2003
    ..e. physical dependence leading to withdrawal seizures) are regulated at the genetic level. This knowledge may help in the development of new strategies for the treatment of alcohol dependence. ..