Genomes and Genes
Summary: Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
Publications232 found, 100 shown here
- Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolismJian Q Feng
Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
Nat Genet 38:1310-5. 2006..Our findings suggest a bone-renal axis that is central to guiding proper mineral metabolism...
- Impact of anthropogenic CO2 on the CaCO3 system in the oceansRichard A Feely
Pacific Marine Environmental Laboratory, National Oceanic and Atmospheric Administration, Seattle, WA 98115 6349, USA
Science 305:362-6. 2004..The total water column CaCO3 dissolution rate for the global oceans is approximately 0.5 +/- 0.2 petagrams of CaCO3-C per year, which is approximately 45 to 65% of the export production of CaCO3...
- Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosisA R Hayman
Department of Medicine, University of Cambridge, Addenbrooke s Hospital, UK
Development 122:3151-62. 1996....
- Impact of near-future ocean acidification on echinodermsS Dupont
Department of Marine Ecology, The Sven Lovén Centre for Marine Sciences, University of Gothenburg, Kristineberg, Sweden
Ecotoxicology 19:449-62. 2010..g. pH, temperature, toxicants) and organism health. However, available data allow us to conclude that near-future OA will have negative impact on echinoderm taxa with likely significant consequences at the ecosystem level...
- The oceanic sink for anthropogenic CO2Christopher L Sabine
National Oceanic and Atmospheric Administration NOAA Pacific Marine Environmental Laboratory, 7600 Sand Point Way NE, Seattle, WA 98115, USA
Science 305:367-71. 2004..The current fraction of total anthropogenic CO2 emissions stored in the ocean appears to be about one-third of the long-term potential...
- Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ storeKarthikeyan Narayanan
Department of Oral Biology, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 278:17500-8. 2003..The data presented here represent a paradigm shift in the understanding of DMP1 function. This information is crucial in understanding normal bone formation, remodeling, fracture healing, and skeletal tissue repair...
- Long-term imatinib therapy promotes bone formation in CML patientsStephen Fitter
Bone and Cancer Research Laboratories, and Division of Haematology, Institute of Medical and Veterinary Science IMVS, The Hanson Institute, Adelaide, SA 5000, Australia
Blood 111:2538-47. 2008..Further investigation is required to determine whether the increase in TBV associated with imatinib therapy may represent a novel therapeutic avenue for the treatment of diseases that are characterized by generalized bone loss...
- Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analysesM Amling
Department of Trauma Surgery, Hamburg University School of Medicine, Germany
Endocrinology 140:4982-7. 1999..The skeletal consequences of VDR ablation are a result of impaired intestinal calcium absorption and/or the resultant secondary hyperparathyroidism and hypophosphatemia...
- Proteins of calcified endoskeleton: II partial amino acid sequences of endoskeletal proteins and the characterization of proteinaceous organic matrix of spicules from the alcyonarian, Synularia polydactylaM Azizur Rahman
Department of Marine and Environmental Sciences, University of the Ryukyus, Okinawa, Japan
Proteomics 5:885-93. 2005..These findings suggest that the endoskeletal spicules of alcyonarian corals have protein-rich organic matrices, which might be related to the calcification process...
- Self-assembly and mineralization of peptide-amphiphile nanofibersJ D Hartgerink
Department of Materials Science and Engineering, Medical School, Northwestern University, 2225 North Campus Drive, Evanston, IL 60208, USA
Science 294:1684-8. 2001..This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone...
- Retinoic acid stimulates annexin-mediated growth plate chondrocyte mineralizationWei Wang
Musculoskeletal Research Laboratory, Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA
J Cell Biol 157:1061-9. 2002....
- Sponge paleogenomics reveals an ancient role for carbonic anhydrase in skeletogenesisDaniel J Jackson
Geoscience Centre Göttingen, Department of Geobiology, Goldschmidtstrasse 3, D 37077 Gottingen, Germany
Science 316:1893-5. 2007....
- Mucins and molluscan calcification. Molecular characterization of mucoperlin, a novel mucin-like protein from the nacreous shell layer of the fan mussel Pinna nobilis (Bivalvia, pteriomorphia)F Marin
Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
J Biol Chem 275:20667-75. 2000....
- Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitroJonathan A R Gordon
Department of Biochemistry and Division of Oral Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Bone 41:462-73. 2007..These results demonstrate that BSP may serve as a matrix-associated signal directly promoting osteoblast differentiation resulting in the increased production of a mineralized matrix...
- Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cellsMika Yamauchi
Dept of Endocrinology, Metabolism, and Hematological Oncology, Shimane Univ School of Medicine, 89 1, Enya cho, Izumo, Shimane, 693 8501, Japan
Am J Physiol Endocrinol Metab 288:E608-16. 2005..This suggests that the CaR may be involved in osteoblastic differentiation...
- Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatiteSivakumar Gajjeraman
Department of Oral Biology, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 282:1193-204. 2007..Such understanding of biomolecule controls on biomineralization promises new insights into the controlled synthesis of crystalline structures...
- Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblastsZhen Xiao
Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
J Cell Physiol 210:325-35. 2007..This investigation represents the first systematic proteomic analysis of MVs and provides insights into both the function and origin of these important mineralization-regulating vesicles...
- Inorganic pyrophosphate generation and disposition in pathophysiologyR A Terkeltaub
Veterans Affairs Medical Center and School of Medicine, University of California, San Diego, California 92161, USA
Am J Physiol Cell Physiol 281:C1-C11. 2001....
- Site-specific in vivo calcification and osteogenesis stimulated by bone sialoproteinJinxi Wang
Laboratory for the Study of Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
Calcif Tissue Int 79:179-89. 2006..These results demonstrate that BSP stimulates calcification and osteogenesis in a site-specific manner, and that local environment and the specificities of responding cells may play critical roles in the function of BSP in vivo...
- FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralizationL Darryl Quarles
Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Endocrinol Metab 285:E1-9. 2003....
- Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralizationLovisa Hessle
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:9445-9. 2002..Our results suggest that inhibiting PC-1 function may be a viable therapeutic strategy for hypophosphatasia. Conversely, interfering with TNAP activity may correct pathological hyperossification because of PP(i) insufficiency...
- Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to boneMonzur Murshed
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030, USA
Genes Dev 19:1093-104. 2005....
- Molecular cloning of a cDNA encoding a soluble protein in the coral exoskeletonIsao Fukuda
Division of Marine Biosciences, Ocean Research Institute, The University of Tokyo, 1 15 1 Minamidai, Nakano, 168 8639, Tokyo, Japan
Biochem Biophys Res Commun 304:11-7. 2003..Galaxin exhibits a novel amino acid sequence which is characterized by a tandem repeat structure. Galaxin transcripts were detected in the adult coral, but not in planktonic larvae...
- Extracellular matrix production and calcium carbonate precipitation by coral cells in vitroYael Helman
Environmental Biophysics and Molecular Ecology Program and Inorganic Analytical Laboratory, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, 71 Dudley Road, New Brunswick, NJ 08901, USA
Proc Natl Acad Sci U S A 105:54-8. 2008..Our results demonstrate the ability of isolated, differentiated coral cells to undergo fundamental processes required for multicellular organization...
- Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animalsDespina Sitara
Department of Developmental Biology, Harvard School of Dental Medicine, REB 303, 188 Longwood Ave, Boston, MA 02115, USA, and The Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
Am J Pathol 169:2161-70. 2006....
- The aminobisphosphonate risedronate preserves localized mineral and material properties of bone in the presence of glucocorticoidsGuive Balooch
Lawrence Berkeley National Laboratory, Berkeley, California, USA
Arthritis Rheum 56:3726-37. 2007....
- Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient miceH Clarke Anderson
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Am J Pathol 164:841-7. 2004..Thus, with TNAP deficiency a buildup of mineral-inhibiting PPi would be expected at the perimeter of MVs...
- Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disordersDympna Harmey
The Burnham Institute, La Jolla, CA 92037, USA
Am J Pathol 164:1199-209. 2004..The hypomineralization observed in Akp2(-/-) mice arises from the combined inhibitory effects of PP(i) and OPN. In contrast, NPP1 or ANK deficiencies cause a decrease in the PP(i) and OPN pools that leads to hypermineralization...
- Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fatHoa Ton Kha
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Bone Miner Res 19:830-40. 2004..Such effects may have important implications for intervention with osteoporosis...
- The degree of mineralization is a determinant of bone strength: a study on human calcaneiH Follet
Laboratoire de Mécanique des Contacts et des Solides LaMCoS, UMR 5514, INSA, Lyon, France
Bone 34:783-9. 2004..The impact of such modifications on fracture risk and the therapeutic implications of these data remain to be analyzed...
- Structure and expression of an unusually acidic matrix protein of pearl oyster shellsDaiki Tsukamoto
Department of Earth and Planetary Sciences, University of Tokyo, Tokyo 113 0033, Japan
Biochem Biophys Res Commun 320:1175-80. 2004..Our findings and previous in vitro experiments taken together suggest that Aspein is responsible for directed formation of calcite in the shell of the pearl oyster Pinctada fucata...
- Metastatic breast cancer cells suppress osteoblast adhesion and differentiationRobyn R Mercer
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA
Clin Exp Metastasis 21:427-35. 2004..These affects could account for the continued loss of bone after osteoclast inhibition in patients with bone-metastatic breast cancer...
- Low temperature FESEM of the calcifying interface of a scleractinian coralP L Clode
Analytical Electron Microscopy Laboratory, Department of Zoology, La Trobe University, Bundoora, VIC 3083, Australia
Tissue Cell 34:187-98. 2002..A thin sheath was also frequently observed adjacent to the apical membrane of calicoblastic cells...
- Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cellsHideaki Sowa
Third Department of Medicine, Kobe University School of Medicine, Japan
J Bone Miner Res 17:1190-9. 2002..We propose that Smad3 plays an important role in osteoblastic bone formation and might help to elucidate the transcriptional mechanism of bone formation and possibly lead to the development of bone-forming drugs...
- Inducers and inhibitors of biomineralization: lessons from pathological calcificationC M Giachelli
Department of Bioengineering, University of Washington, Seattle, 98195, USA
Orthod Craniofac Res 8:229-31. 2005..Over the past several years, we have developed in vitro and in vivo models of ectopic calcification to investigate potential inducers and inhibitors of this process...
- Cissus quadrangularis extract enhances biomineralization through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblastsDuenpim Parisuthiman
Faculty of Dentistry, Thammasat University, 99 Moo 18, Paholyothin Rd, Klong Luang, Pathumthani, 12121, Thailand
In Vitro Cell Dev Biol Anim 45:194-200. 2009..These results suggested that CQ-E may regulate osteoblastic activity by enhancing ALP activity and mineralization process, and the increased ALP activity effect of CQ-E is likely mediated by MAPK-dependent pathway...
- Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) miceDympna Harmey
Burnham Institute for Medical Research, La Jolla, California 92037, USA
J Bone Miner Res 21:1377-86. 2006..We also found that extracellular OPN regulates the PP(i) output by osteoblasts...
- Bone mineral and collagen quality in iliac crest biopsies of patients given teriparatide: new results from the fracture prevention trialEleftherios P Paschalis
Mineralized Tissue Section, Research Division, The Hospital for Special Surgery, New York, New York 10021, USA
J Clin Endocrinol Metab 90:4644-9. 2005..Matrix mineralization, hydroxyapatite characteristics, and collagen cross-link ratio are key determinants of material properties. Fourier transform infrared imaging (FTIRI) yields data on these characteristics from bone sections...
- Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilageT Kirsch
Department of Anatomy Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Osteoarthritis Cartilage 8:294-302. 2000..To test the hypothesis that terminal differentiation of chondrocytes in human osteoarthritic cartilage might lead to the failure of repair mechanisms and might cause progressive loss of structure and function of articular cartilage...
- The effect of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnoverBabul Borah
Procter and Gamble Pharmaceuticals, Inc, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA
Bone 37:1-9. 2005..The results demonstrate that the reduction of turnover by risedronate increased the degree of mineralization and reduced the ratio of low- to high-mineralized bone fractions which may increase bone's resistance to fracture...
- The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged estrogen-deficient rats and is a strong predictor of bone strengthWei Yao
Department of Medicine, Aging Center, UC Davis Medical Center, Sacramento, CA 95817, USA
Bone 41:804-12. 2007....
- Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiationO Fromigue
INSERM Unit 349, Cell and Molecular Biology of Bone and Cartilage, Lariboisiere Hospital, Paris, France
J Cell Biochem 68:411-26. 1998..These observations suggest that TGF-beta2 and BMP-2 may act in a sequential manner at different stages to promote human bone marrow stromal cell differentiation towards the osteoblast phenotype...
- Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: sequential triple biopsy studies with micro-computed tomographyB Borah
Procter and Gamble Pharmaceuticals, Inc Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA
Bone 39:345-52. 2006..Overall, risedronate provided sustained benefits on mineralization and architecture, two key determinants of bone strength, over 5 years lending support for its long-term efficacy in fracture risk reduction...
- Histomorphometric evidence for increased bone turnover without change in cortical thickness or porosity after 2 years of cyclical hPTH(1-34) therapy in women with severe osteoporosisA B Hodsman
Department of Medicine and Lawson Research Institute, University of Western Ontario, London, ON, Canada
Bone 27:311-8. 2000....
- Effects of ibandronate on bone quality: preclinical studiesF Bauss
Department of Pharmacology, Roche Diagnostics GmbH, Pharma Research Penzberg, Nonnenwald 2, Building 231 Room 579, D 82377 Penzberg, Germany
Bone 40:265-73. 2007..This review describes the preclinical evidence for the preservation of bone quality with ibandronate, irrespective of the dosing regimen and even when administered at doses higher than those used therapeutically...
- Bone material properties in trabecular bone from human iliac crest biopsies after 3- and 5-year treatment with risedronateErich Durchschlag
Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria
J Bone Miner Res 21:1581-90. 2006..This effect may be contributing to risedronate's antifracture efficacy...
- The two-step mode of growth in the scleractinian coral skeletons from the micrometre to the overall scaleJean Pierre Cuif
UMR 8148 IDES, Geology, Bat 504, Université Paris XI Orsay, F 91405 Orsay cedex, France
J Struct Biol 150:319-31. 2005..Clearly, at the overall ontogenic level, the two-step growth mode of coral skeletons is also a valuable tool to reconstruct the evolutionary history of Scleractinia...
- Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expressionXiuying Bai
Division of Endocrinology, Department of Medicine, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Sainte Catherine Road, Montreal, Quebec, Canada H3T 1E2
Mol Endocrinol 16:2913-25. 2002....
- Raloxifene and teriparatide (hPTH 1-34) have complementary effects on the osteopenic skeleton of ovariectomized ratsYanfei L Ma
Lilly Research Laboratories, Lilly Corporate Center, Bldg 98C B, DC 0403, Indianapolis, IN 46285, USA
J Bone Miner Metab 23:62-8. 2005..Raloxifene inhibited bone resorption, and reduced high bone turnover without significantly retarding TPTD stimulation of bone formation activity...
- Bone metabolism and bone mineral density in childhood hypophosphatasiaH J Girschick
Children s Hospital, University of Wurzburg, Germany
Bone 25:361-7. 1999..Hypermineralization/sclerosis of trabecular bone might serve as a compensation for a mechanically incompetent bony structure due to an impaired mineralization of cartilage caused by the genetic deficiency of alkaline phosphatase...
- Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic womenP Roschger
Ludwig Boltzmann Institute of Osteology, Fourth Medical Department, Hanusch Krankenhaus and Unfallkrankenhaus Meidling, Vienna, Austria
Bone 29:185-91. 2001..It also decreases the porosity of the corticalis. Together these effects may contribute to the observed reduction in fractures...
- Effects of 3- and 5-year treatment with risedronate on bone mineralization density distribution in triple biopsies of the iliac crest in postmenopausal womenRuth Zoehrer
Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Vienna, Austria
J Bone Miner Res 21:1106-12. 2006..These changes at the material level of bone could contribute to risedronate's antifracture efficacy...
- Purification of a soluble glycoprotein from the uncalcified ecdysial cuticle of the blue crab Callinectes sapidus and its possible role in initial mineralizationElizabeth P Tweedie
Department of Biological Sciences, University of North Carolina at Wilmington, Wilmington, NC, USA
J Exp Biol 207:2589-98. 2004..This strengthens the hypothesis that the glycoprotein under investigation is an inhibitor of calcite nucleation or of initial amorphous calcium carbonate accumulation...
- Transient precursor strategy in mineral formation of boneSteve Weiner
Bone 39:431-3. 2006..Bone (In press), using micro-Raman spectroscopy to study early mineral deposits in mice calvaria, provides strong evidence that the transient precursor strategy also occurs in vertebrates...
- Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein familyKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Exp Zool B Mol Dev Evol 306:295-316. 2006..Thus, the evolution of vertebrate mineralized tissues seems to be explained by phenogenetic drift: while mineralized tissues are retained during vertebrate evolution, the underlying genetic basis has extensively drifted...
- Transient precursor strategy or very small biological apatite crystals?Marc D Grynpas
Bone 41:162-4. 2007....
- The role of matrix vesicles in growth plate development and biomineralizationH Clarke Anderson
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA lt
Front Biosci 10:822-37. 2005....
- Ovalbumin is a component of the chicken eggshell matrixM T Hincke
Department of Anatomy and Neurobiology, University of Ottawa, Ottawa, Canada
Connect Tissue Res 31:227-33. 1995..However, it is not yet clear whether ovalbumin at this site plays a specific role in shell mineralization...
- Cloning of ovocalyxin-36, a novel chicken eggshell protein related to lipopolysaccharide-binding proteins, bactericidal permeability-increasing proteins, and plunc family proteinsJoel Gautron
Institut National de la Recherche Agronomique, UR83 Unité de Recherches Avicoles, F 37380 Nouzilly, France
J Biol Chem 282:5273-86. 2007..OCX-36 may therefore participate in natural defense mechanisms that keep the egg free of pathogens...
- Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient miceH Clarke Anderson
Dept of Pathology and Lab Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Am J Pathol 166:1711-20. 2005..Thus, the osteomalacia of Akp2-/- mice and the hypomineralized phenotype of the long bones of Enpp1-/- mice are not rescued by simultaneous deletion of TNAP and NPP1 functions...
- Study of calcification during a daily cycle of the coral Stylophora pistillata: implications for 'light-enhanced calcification'Aurélie Moya
Centre Scientifique de Monaco, Avenue Saint Martin, MC 98000 Principality of Monaco
J Exp Biol 209:3413-9. 2006....
- The carbonic anhydrase domain protein nacrein is expressed in the epithelial cells of the mantle and acts as a negative regulator in calcification in the mollusc Pinctada fucataHiroshi Miyamoto
Faculty of Biology Oriented Science and Technology, Department of Molecular Genetics, Kinki University, Uchita, Wakayama, Japan
Zoolog Sci 22:311-5. 2005..Together these studies suggest that nacrein functions as a negative regulator in calcification in the extrapallial space between the shell and the mantle by inhibiting the precipitation of CaCO3...
- A comparative analysis of strategies for isolation of matrix vesiclesM Balcerzak
Department of Cellular Biochemistry, Nencki Insitute of Experimental Biology, Polish Academy of Sciences, 02 093 Warsaw, Poland
Anal Biochem 361:176-82. 2007....
- Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralizationScott Roberts
Bone Biology Group, Roslin Institute, Edinburgh, Scotland, UK
J Bone Miner Res 22:617-27. 2007..PHOSPHO1 expression was present within matrix vesicles, and inhibition of enzyme action caused a decrease in the ability of matrix vesicles to calcify...
- DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysisYunfeng Ling
Musculoskeletal Integrity Program, Hospital for Special Surgery, New York, New York, USA
J Bone Miner Res 20:2169-77. 2005..The observed decreased mineral content in dmp1 null mice indicates a key role for dmp1 in bone mineralization. Indirect effects of DMP1 on other systems also determine the KO phenotype...
- Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphatePatrik Lundquist
Institute for Physiology and Center for Integrative Human Physiology, University of Zurich, Switzerland
Cell Physiol Biochem 19:43-56. 2007..Their expression thus seem regulated by phosphate in a manner consistent with their playing a role in transcellular P(i) flux during mineralization...
- Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activityWilliam N Addison
Faculty of Dentistry, McGill University, Montreal, Quebec H3A 2B2, Canada
J Biol Chem 282:15872-83. 2007..In summary, PP(i) prevents mineralization in MC3T3-E1 osteoblast cultures by at least three different mechanisms that include direct binding to growing crystals, induction of Opn expression, and inhibition of Tnap activity...
- Proteomic analysis of the acid-soluble organic matrix of the chicken calcified eggshell layerKarlheinz Mann
Max Planck Institut fur Biochemie, Abteilung für Proteomics und Signaltransduktion, Am Klopferspitz 18, D 82152 Martinsried, Germany
Proteomics 6:3801-10. 2006....
- Calcium associated with a fibrillar organic matrix in the scleractinian coral Galaxea fascicularisP L Clode
Analytical Electron Microscopy Laboratory, Department of Zoology, La Trobe University, Melbourne, Victoria
Protoplasma 220:153-61. 2003..This arrangement conforms with the criteria necessary for biomineralisation and with the long-held theory that organic matrices may act as templates for crystal formation and growth in biological mineralising systems...
- Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2/CbfalBenjamin A Byers
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, USA
J Bone Miner Res 17:1931-44. 2002..These results suggest that, although functional Runx2 is essential to multiple osteoblast-specific activities, in vitro matrix mineralization requires additional tissue-specific cofactors, which supplement Runx2 activity...
- Construction of an alkaline phosphatase-liposome system: a tool for biomineralization studyFernando L Camolezi
Departamento de Quimica, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto FFCLRP USP, SP, Brazil
Int J Biochem Cell Biol 34:1091-101. 2002..The standardization of such system allows the study of the effect of phospholipids and the enzyme in in vitro and in vivo mineralization, since it reproduces many essential features of the matrix vesicle...
- Phytoplankton calcification in a high-CO2 worldM Debora Iglesias-Rodriguez
National Oceanography Centre, Southampton, University of Southampton Waterfront Campus, European Way, Southampton SO14 3ZH, UK
Science 320:336-40. 2008..Our findings show that coccolithophores are already responding and will probably continue to respond to rising atmospheric CO2 partial pressures, which has important implications for biogeochemical modeling of future oceans and climate...
- Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotypeShiguang Liu
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:3686-97. 2002....
- Effects of exogenous N-acetylhexosaminidase on the structure and mineralization of the post-ecdysial exoskeleton of the blue crab, Callinectes sapidusD C Pierce
Department of Biological Sciences, University of North Carolina at Wilmington, 601 South College Road, Wilmington, NC 28403-3297, USA
Comp Biochem Physiol B Biochem Mol Biol 128:691-700. 2001..The data imply a role of the cuticular HexNAcase-like enzyme in the initiation of calcite nucleation in the newly formed exoskeleton...
- Bone mineral acquisition in healthy Asian, Hispanic, black, and Caucasian youth: a longitudinal studyL K Bachrach
Department of Pediatrics, Stanford University School of Medicine, California 94305 5208, USA
J Clin Endocrinol Metab 84:4702-12. 1999..Black and Asian females and Asian males tended to reach a plateau in BMD earlier than the other ethnic groups. The use of gender- and ethnic-specific standards is recommended when interpreting pediatric bone densitometry data...
- Molecular cloning and ultrastructural localization of the core protein of an eggshell matrix proteoglycan, ovocleidin-116M T Hincke
Department of Cellular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
J Biol Chem 274:32915-23. 1999..Ovocleidin-116 thus is a candidate molecule for the regulation of calcite growth during eggshell calcification...
- Spatiotemporal assessment of fetal bovine osteoblast culture differentiation indicates a role for BSP in promoting differentiationL F Cooper
Department of Prosthodontics, University of North Carolina School of Dentistry, Chapel Hill 27599 7450, USA
J Bone Miner Res 13:620-32. 1998..Matrix protein-cell interactions may be examined using this spatiotemporally defined model...
- Cloning and targeted deletion of the mouse fetuin geneW Jahnen-Dechent
Institut für Physiologische Chemie und Pathobiochemie, Johannes Gutenberg Universitat, Duesbergweg 6, D 55099 Mainz, Federal Republic of Germany
J Biol Chem 272:31496-503. 1997..These results corroborate a role for fetuin in serum calcium homeostasis. The fact that generalized ectopic calcification did not occur in fetuin-deficient mice proves that additional inhibitors of phase separation exist in serum...
- Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasiaS Narisawa
The Burnham Institute, La Jolla Cancer Research Center, California 92037, USA
Dev Dyn 208:432-46. 1997..5 and E13.5 of embryogenesis. We hypothesize that the autonomic nervous system is compromised in these TNAP-/- mice...
- The carboxyl-terminal domain of phosphophoryn contains unique extended triplet amino acid repeat sequences forming ordered carboxyl-phosphate interaction ridges that may be essential in the biomineralization processA George
Northwestern University, Chicago, Illinois 60611, USA
J Biol Chem 271:32869-73. 1996..These two domains and the colocalization of Dmp1 and Dmp2 genes at a position equivalent to the dentinogenesis imperfecta type II location on human 4q21 all suggest that the PPs are indeed involved in some aspect of ECM mineralization...
- Evidence of the presence of a specific ATPase responsible for ATP-initiated calcification by matrix vesicles isolated from cartilage and boneH H Hsu
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160 7410, USA
J Biol Chem 271:26383-8. 1996....
- Bone-like nodules formed by human bone marrow stromal cells: comparative study and characterizationN Schecroun
Orthopaedic Research Laboratory, Avenue Mounier, 53, Universite Catholique de Louvain, B 1200, Brussels, Belgium
Bone 32:252-60. 2003..Thus, this differentiation model could provide a new tool to elaborate an autologous cell therapy designed to enhance osteogenesis...
- Altered pH regulation during enamel development in the cystic fibrosis mouse incisorW Sui
Department of Pediatric Dentistry, Brauer Hall CB 7450, School of Dentistry, University of North Carolina, Chapel Hill 27599 7450, USA
J Dent Res 82:388-92. 2003..These results indicate that CFTR plays a role in pH regulation during enamel development and that a reduced pH results in a lack of calcium influx during enamel maturation and hypomineralization of the CF incisor enamel...
- Bone acidic glycoprotein-75 delineates the extracellular sites of future bone sialoprotein accumulation and apatite nucleation in osteoblastic culturesRonald J Midura
Department of Biomedical Engineering and The Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic and Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 279:25464-73. 2004..Furthermore, we propose a hypothetical mechanism in which BAG-75 and BSP function actively in nucleation of apatite within BMF...
- Extracellular bone acidic glycoprotein-75 defines condensed mesenchyme regions to be mineralized and localizes with bone sialoprotein during intramembranous bone formationJeff P Gorski
Division of Biochemistry and Molecular Biology, School of Biological Sciences, School of Dentistry, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
J Biol Chem 279:25455-63. 2004....
- Molecular analyses of protein components of the organic matrix in the exoskeleton of two scleractinian coral speciesToshiki Watanabe
Division of Marine Bioscience, Ocean Research Institute, The University of Tokyo, 1 15 1 Minamidai, Nakano, Tokyo 164 8639, Japan
Comp Biochem Physiol B Biochem Mol Biol 136:767-74. 2003..Preliminary characterization of the T. aurea proteins showed that two proteins bound Ca(2+), and suggested that the major protein of 46 kDa was not homologous to galaxin...
- Increased bone formation in osteocalcin-deficient miceP Ducy
Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Nature 382:448-52. 1996..To our knowledge, this study provides the first evidence that osteocalcin is a determinant of bone formation...
- Molluscan shell proteins: primary structure, origin, and evolutionFrederic Marin
UMR CNRS 5561 Biogeosciences, Université de Bourgogne 6 Boulevard Gabriel, 21000 Dijon, France
Curr Top Dev Biol 80:209-76. 2008..Consequently, the molluscan shell matrix may be a source of bioactive molecules that would offer interesting perspectives in biomaterials and biomedical fields...
- Inorganic phosphate as a signaling molecule in osteoblast differentiationGeorge R Beck
National Cancer Institute at Frederick, Center for Cancer Research, Basic Research Laboratory, Frederick, Maryland 21702, USA
J Cell Biochem 90:234-43. 2003..The regulation of protein function and gene expression by elevated inorganic phosphate during osteoblast differentiation may represent a mechanism by which mineralizing cells monitor and respond to the changing extracellular environment...
- Collagen XXIV (Col24a1) gene expression is a specific marker of osteoblast differentiation and bone formationNoritaka Matsuo
Laboratory of Genetics and Organogenesis, Research Division of the Hospital for Special Surgery, New York, New York, USA
Connect Tissue Res 49:68-75. 2008..These findings lend further support to the hypothesis that collagen XXIV may be implicated in the formation of a mineralization-competent bone matrix...
- Osteoblast differentiation is enhanced in rotary cell culture simulated microgravity environmentsY Joon Ko
Department of Prosthodontics, College of Dentistry, University of Iowa, Iowa City, IA, USA
J Prosthodont 16:431-8. 2007..The objective of this study was to test the hypothesis that 3D rotary cell culture (RCC) environments created by simulated microgravity would enhance osteogenic gene expression using integrin mediated pathways...
- Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralizationAkemichi Ueno
Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
J Cell Physiol 209:322-32. 2006..These results indicate that TSP1 functions as an inhibitory regulator of bone mineralization and matrix production by osteoblasts to sustain bone homeostasis...
- Increased levels of xylosyltransferase I correlate with the mineralization of the extracellular matrix during osteogenic differentiation of mesenchymal stem cellsBenjamin Müller
Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabesteszentrum NRW, Universitatsklinik der Ruhr Universitat Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany
Matrix Biol 27:139-49. 2008..The synchronized expression profiles demonstrate the coordinated biosynthesis of the PGs during bone formation and osteogenic stem cell differentiation occurring in parallel to the mineralization of the extracellular matrix...
- HIV proteins regulate bone marker secretion and transcription factor activity in cultured human osteoblasts with consequent potential implications for osteoblast function and developmentEoin J Cotter
General Clinical Research Unit, School of Medicine and Medical Sciences, University College Dublin, Ireland
AIDS Res Hum Retroviruses 23:1521-30. 2007..HIV proteins can potentially modulate OB development and function in vitro via modulation of bone maker secretion and RUNX-2 and PPARgamma transcription factor activity...
- Effects of zinc on the mineralization of bone nodules from human osteoblast-like cellsAleksandra Cerovic
Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Biol Trace Elem Res 116:61-71. 2007..These findings demonstrate that zinc has biphasic effects on the differentiation and mineralization of human osteoblast-like cells...
- Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in boneMelita M Dvorak
Cardiff University School of Biosciences, UK
J Am Soc Nephrol 18:2509-16. 2007..Therefore, in addition to their use as antihypertensive drugs, our results suggest that thiazides may find a role in the prevention and treatment of osteoporosis...
- Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and BMP2Xiaoling Zhang
Joint Orthopaedic Laboratory of Institute of Health Sciences and Shanghai Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai, People s Republic of China
J Orthop Res 26:314-21. 2008....
- Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose--derived stem cells in vitro and in vivoX Zhang
Department of Sports Medicine, Peking University Third Hospital, Beijing 100083, China
Calcif Tissue Int 79:169-78. 2006..Our work demonstrates a potential new approach for bone repair using Runx2-modified ADSCs for bone tissue engineering...
- L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitroS Colucci
Department of Human Anatomy and Histology, University of Bari, Bari, Italy
Calcif Tissue Int 76:458-65. 2005..In conclusion these data suggest that carnitine and, in particular, its new derivative, Iso-V-LC supplementation in the elderly may stimulate osteoblast activity and decrease age-related bone loss...
- Inductive effects of dexamethasone on the mineralization and the osteoblastic gene expressions in mature osteoblast-like ROS17/2.8 cellsYoshikazu Mikami
Department of Anatomy, Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
Biochem Biophys Res Commun 362:368-73. 2007....
- Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivoMing K Chang
Institute for Molecular Bioscience, Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland, Brisbane, Queensland, Australia
J Immunol 181:1232-44. 2008..These observations implicate OsteoMacs, in addition to osteoclasts and osteoblasts, as principal participants in bone dynamics...
- Osteopontin: a Novel Biomarker for Calcific Aortic Valve DiseasesGiovanni Ferrari; Fiscal Year: 2010..We propose a translational research study aim to characterize tissue- and blood-derived osteopontin as a predictor for the degree and progression of aortic valve calcification ..
- OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICSAdele Boskey; Fiscal Year: 2003..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
- Micro-computed tomography system (Micro-CT)Adele Boskey; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- MECHANISM OF HARD TISSUE MINERALIZATIONAdele L Boskey; Fiscal Year: 2010..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
- IN VITRO INITIATION OF BIOLOGICAL CALCIFICATIONAdele Boskey; Fiscal Year: 2009....
- Initiation and Inhibition of Medial Artery CalcificationPaul Price; Fiscal Year: 2008..abstract_text> ..
- MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATIONPaul Price; Fiscal Year: 2001..The investigators will further study the demonstrated ability of MGP to inhibit calcification in supersaturated solutions, and will investigate the ability of MGP to inhibit matrix vesicle -initiated calcification. ..
- MINERALIZATION STUDIES RELATED TO ORAL BIOLOGYHARRISON ANDERSON; Fiscal Year: 2005..New knowledge of matrix vesicle calcification can be applied to a broad range of topics including specific diseases in which abnormal calcification occurs. ..
- 5 LIPOXYGENASE IN BONELynda Bonewald; Fiscal Year: 2001..Hence, these studies may also have profound implications for the increasing number of asthmatic patients who are currently being treated with steroids and 5LO inhibitors. ..
- Regulation of Vascular Calcification in DiabetesXUENING CHEN; Fiscal Year: 2007....
- Common Mediators of Vascular Calcification and Bone Dis*Cecilia Giachelli; Fiscal Year: 2004..Aim 3 will determine the effect of hyperlipidemia on cartilaginous metaplasia, vascular calcification and osteoporosis in a mouse model of atherosclerosis...
- STRUCTURAL STUDIES OF MATRIX PROTEINS IN TEETH AND BONESSTEPHEN WEINER; Fiscal Year: 2007..abstract_text> ..
- MECHANISM FOR BONE SIALOPROTEIN TO NUCLEATE BIOAPATITERONALD MIDURA; Fiscal Year: 2002..abstract_text> ..
- MECHANISM OF MATRIX VESICLE BIOGENESISEllis Golub; Fiscal Year: 2004..This information is crucial for developing new approaches to metabolic bone diseases such as Pagets's disease of bone and osteoporosis, and may also contribute to novel therapies for the repair of craniofacial defects and fracture. ..
- Calcium Absorption and Bone Formation During PubertySteven Abrams; Fiscal Year: 2005....
- MINERALIZATION OF PRIMARY BONEJEFFREY GORSKI; Fiscal Year: 2008..Results of this work should better define the differences between primariy and lamellar bone, as well as aid in the diagnosis and treatment of osteoporosis and atherosclerosis. ..
- BAG-75: UNIQUE MARKER OF PRIMARY BONE FORMATIONJEFFREY GORSKI; Fiscal Year: 2003..Stimulation of appositional formation by lamellar bone would not be expected to have the same effect. These future functional studies require determination of the BAG-75 cDNA sequence. ..
- ROLES OF BMP4 & ITS REGULATION DURING TOOTH DEVELOPMENTJian Feng; Fiscal Year: 2003..Research into this relatively unexplored area will contribute to our understanding of the basic Msx1- Bmp4 signal pathway, mechanisms of tooth formation, and possible cause of autosomal dominant forms of familial tooth agenesis. ..
- Inflammation, the metabolic syndrome and atherosclerosisMuredach Reilly; Fiscal Year: 2006..abstract_text> ..
- ANK and Joint Ankylosis in SpondylitisRobert Terkeltaub; Fiscal Year: 2008..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
- SYNTHESIS OF OSTEOCALCIN IN BONEJane Lian; Fiscal Year: 2006..These studies will establish the importance of bone selective transcription factor complexes for formation, maintenance and remodeling of bone tissue. ..
- Bioengineering Annulus Fibrosus using Silk ScaffoldRita Kandel; Fiscal Year: 2006..The viability and mechanical properties of the tissue will be evaluated. ..
- Sun Valley Workshop on Skeletal BiologyDavid Burr; Fiscal Year: 2006..There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. [unreadable] [unreadable] [unreadable] [unreadable]..
- DENTIN BIOMINERALIZATIONCharles Sfeir; Fiscal Year: 2007..This data will also provide basic knowledge for designing treatment of ectopic mineralization specifically in diseases as such kidney stones or failing heart valve prosthesis. ..
- WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTHSarah E Millar; Fiscal Year: 2010..abstract_text> ..
- A BABOON MODEL FOR THE GENETICS OF CORTICAL BONE MATERIAL PROPERTIESLORENA HAVILL; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- RANKL/OPG-Mediated Control of Vascular CalcificationLinda L Demer; Fiscal Year: 2010..Based on new supportive evidence, this research will test whether specific regulatory factors that promote loss of mineral from bone also promote gain of mineral in the artery wall. ..
- Genes Controlling the Renal Handling of PhosphateRalph Meyer; Fiscal Year: 2004..Such intervention may improve the skeletal symptoms of patients with hypophosphatemic bone disease and improve their quality of life. ..
- ROLES OF BMP4 AND ITS REGULATION IN TOOTH DEVELOPMENTJian Feng; Fiscal Year: 2004..Molecular techniques include RT-PCR, in situ hybridization, DNA sequence determination, SSCP (single strand conformational polymorphism), and heteroduplex analysis. ..
- THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTAJohn Wright; Fiscal Year: 2004..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
- S100A4: A Novel Regulator of BiomineralizationWAGNER DUARTE; Fiscal Year: 2003..The combination of this in vitro/in vivo approach would provide insights into the potential regulatory roles of S1004A4 in osteoblast differentiation and biomineralization. ..
- MRI Visceral Adipose Tissue Partitioning:Advanced ModelsSteven Heymsfield; Fiscal Year: 2005..Our findings could help to set new standards for VAT and adipose tissue subcompartment measurement, lower the cost of MRI body composition studies, and improve study power. ..
- PTH and Mineralization: Role of Matrix Gla ProteinRajaram Gopalakrishnan; Fiscal Year: 2005..abstract_text> ..
- GLUCOCORTICOID-INDUCED OSTEOPENIA IN CHILDRENMary Leonard; Fiscal Year: 2005..The accurate characterization of GC and disease effects on skeletal development is necessary to identify and evaluate targeted therapies to optimize skeletal architecture and peak bone mass in childhood. ..
- Multidiscipli. GCRC-Mentorship Program in Womens HealthLorraine Fitzpatrick; Fiscal Year: 2003..abstract_text> ..
- INTERDISCIPLINARY RESEARCH PROGRAM FOR UNDERGRADUATESClinton Rubin; Fiscal Year: 2004..Indeed, it is hoped that the most successful of these students will enter our own graduate training programs in the biomedical sciences. ..
- MOLECULAR BASIS OF CALCIUM PYROPHOSPHATE DEPOSITIONIkuko Masuda; Fiscal Year: 2002..It is hoped that these studies will lead to therapies to reduce ePPi accumulation and reduce subsequent cartilage degeneration. ..
- Magnesium Deficiency: Effect on Bone and MineralRobert Rude; Fiscal Year: 2004..These studies should substantiate our hypothesis that Mg depletion contributes to osteoporosis and provide mechanistic explanations. ..
- Genetic Analysis of Bone Structure and StrengthCharles Turner; Fiscal Year: 2008..abstract_text> ..
- LECTIN-LIKE PROPERTIES OF AMELOGENINSRAJESWARI RAVINDRANATH; Fiscal Year: 2004..These experiments are a logical extension of the newly identified lectin-like properties of amelogenins (Ravindranath et al. Submitted), which are postulated to play a functional role in normal enamel biomineralization. ..
- A gene-trap screen for hearing and balanceDONNA FEKETE; Fiscal Year: 2008..Our long-term goal is to determine whether any of the newly discovered hearing-related genes in zebrafish also correspond to genes underlying congenital deafness in humans. [unreadable] [unreadable] [unreadable]..
- Genetics of atherosclerosis in renal diseaseMuredach P Reilly; Fiscal Year: 2010....
- A MECHANISTIC STUDY OF SKELETAL ACTIONS OF 1-34hPTHRobert Lindsay; Fiscal Year: 2009..abstract_text> ..
- Mineralization: Integrins and Focal Adhesion KinaseGalen Schneider; Fiscal Year: 2003..This will allow for development of new therapeutic approaches that in turn could lead to novel treatments and tissue-engineered biological applications to increase the quality of life for many patients. ..
- Spectroscopic identification /removal of PMMA from boneNancy Pleshko; Fiscal Year: 2005....
- 4th International Conference on Children's Bone HealthMary Leonard; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MAP KINASE REGULATION OF OSTEOBLAST FUNCTIONRenny Franceschi; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- REGULATION OF BETA-CATENIN NUCLEARIZATIONCHARLES ETTENSOHN; Fiscal Year: 2006..In addition, using dominant negative constructs and morpholinos, we will examine the developmental function of two regulators of GSK3 activity, disheveled and Akt/PKB. ..
- Increasing physical activity of sedentary youthJAMES ROEMMICH; Fiscal Year: 2005..This study will yield important information on new ways to increase the physical activity of children. ..
- MUSCULOSKELETAL TRAINING GRANTDavid Burr; Fiscal Year: 2006..Two presentations were nominated for Young Investigator Awards by the ASBMR and the ORS. ..
- NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASEMARK HAUSSLER; Fiscal Year: 2007..abstract_text> ..
- A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATIONJANET OLDAK; Fiscal Year: 2004..abstract_text> ..
- Chondrocyte S100/Calgranulins and RAGE in OsteoarthritisRobert Terkeltaub; Fiscal Year: 2009..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
- Gene-Augmented Mesenchymal Stem Cells in Bone RepairTerri Zachos; Fiscal Year: 2006..We hypothesize that gene delivery of two different BMPs will result in accelerated healing of fractures, but by different mechanisms, confirmed by the production of unique cartilage- and bone-specific messages. [unreadable] [unreadable]..
- BIOMIMETIC SCAFFOLD FOR BONE-REPAIRAnne George; Fiscal Year: 2007..abstract_text> ..
- Synchrotron-Based Infrared Microscope for Chemical Imaging of DiseaseLisa Miller; Fiscal Year: 2007..This instrument will be unique worldwide. [unreadable] [unreadable] [unreadable]..
- Lipid Regulation of Vascular and Bone OsteoclastogenesisLinda Demer; Fiscal Year: 2004....
- Structural Bone Disease in Chronic Renal InsufficiencyMary Leonard; Fiscal Year: 2007..Accurate characterization of bone structure in CRI is necessary to identify risk factors for fragility, and to evaluate potential therapies. ..
- A Critical Role of DMP-1 in MineralizationJian Feng; Fiscal Year: 2007..unreadable] [unreadable]..
- Integrated Tomosynthetic Perfusion and Cone-beam CT Imaging on a C-arm GantryGuang Hong Chen; Fiscal Year: 2009..The new interventional platform will not only benefit those at researchcenters,but also will enable image-guided interventional stroke treatmentsfor hospitals without advanced imaging facilities. ..
- 3D Time-resolved Tomographic Interventional PlatformGuang Hong Chen; Fiscal Year: 2004....
- Persistent changes in brain expression after withdrawalKRISTINE WIREN; Fiscal Year: 2003..e. physical dependence leading to withdrawal seizures) are regulated at the genetic level. This knowledge may help in the development of new strategies for the treatment of alcohol dependence. ..